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Jean-Philippe Pin

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Etienne Doumazane; Ludovic Fabre; Jean-Philippe Pin; Pauline Scholler; Eric Trinquet; Jurriaan M Zwier; Philippe Rondard
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors.
Jean-Philippe Pin
Tuning synaptic activity with light-controlled GPCRs.
Marianne Amalric; Giuseppe Battaglia; G Fisone; Cyril Goudet; S Lopez; F Nicoletti; Jean-Philippe Pin; Francine Acher
Group III and subtype 4 metabotropic glutamate receptor agonists: discovery and pathophysiological applications in Parkinson's disease.

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2013: Etienne Doumazane; Ludovic Fabre; Jean-Philippe Pin; Pauline Scholler; Eric Trinquet; Jurriaan M Zwier; Philippe Rondard
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):E1416-25.
2013: Jean-Philippe Pin
Tuning synaptic activity with light-controlled GPCRs.
Nature neuroscience 2013;16(4):377-9.
2013: Marianne Amalric; Giuseppe Battaglia; G Fisone; Cyril Goudet; S Lopez; F Nicoletti; Jean-Philippe Pin; Francine Acher
Group III and subtype 4 metabotropic glutamate receptor agonists: discovery and pathophysiological applications in Parkinson's disease.
Neuropharmacology 2013;66():53-64.
2013: Pauline Scholler; Eric Trinquet; Jurriaan M Zwier; Jean-Philippe Pin; Laurent Prézeau; Philippe Rondard; Julie Kniazeff
Time-resolved Förster resonance energy transfer-based technologies to investigate G protein-coupled receptor machinery: high-throughput screening assays and future development.
Progress in molecular biology and translational science 2013;113():275-312.
2012: Driss El Moustaine; Sébastien Granier; Bernard Mouillac; Jean-Louis Banères; Patrick Bron; Etienne Doumazane; Rita Rahmeh; Philippe Rondard; Pauline Scholler; Jean-Philippe Pin
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):16342-7.
2012: Julie Kniazeff; Jean-Philippe Pin
[G-protein-coupled receptors dimers and oligomers: for which purpose? The GABA(B) receptor under investigation].
Médecine sciences : M/S 2012;28(10):858-63.
2012: Veronika Hlavackova; Carsten Hoffmann; Julia Bätz; Jaroslav Blahos; Daniela Frankova; Jean-Philippe Pin; Laurent Prezeau; Ulrike Zabel; Martin J Lohse
Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1.
Science signaling 2012;5(237):ra59.
2012: Laëtitia Comps-Agrar; Julie Kniazeff; Carsten Brock; Eric Trinquet; Jean-Philippe Pin
Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(8):3430-9.
2012: Yong Geng; Jonathan A Javitch; Julie Kniazeff; David L Malito; Lidia Mosyak; Jean-Philippe Pin; Matthias Quick; Dazhi Xiong; Svetlana Burmakina; Martin Bush; Yan Chen; Qing R Fan
Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Nature neuroscience 2012;15(7):970-8.
2012: F Fazio; Francine Acher; Giuseppe Battaglia; Hugues-Olivier BERTRAND; Valeria Bruno; M Curini; R Di Marco; L Lionetto; Gemma Molinaro; Richard Teke Ngomba; F Nicoletti; S Notartomaso; Jean-Philippe Pin; O Rosati; P Scarselli; M Simmaco; Cyril Goudet
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.
Molecular pharmacology 2012;81(5):643-56.
2012: Cyril Goudet; Heather McLean; Nadia Oueslati; Delphine Rigault; Bruno Vilar; Francine Acher; Marianne Amalric; Hugues-Olivier BERTRAND; Thomas Bessiron; Isabelle Brabet; Tiphanie Courtiol; Hervé Daniel; Thierry Deltheil; Jean-Philippe Pin
A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(4):1682-93.
2012: Martin Cottet; Etienne Doumazane; Orestis Faklaris; Damien Maurel; Jean-Philippe Pin; Pauline Scholler; Eric Trinquet; Thierry Durroux
BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues.
Frontiers in endocrinology 2012;3():92.
2012: Mohammed Akli Ayoub; Abdulrahman Al-Senaidy; Jean-Philippe Pin
Receptor-G protein interaction studied by bioluminescence resonance energy transfer: lessons from protease-activated receptor 1.
Frontiers in endocrinology 2012;3():82.
2011: Siluo Huang; Ming Jiang; Gilles Labesse; jianfeng Liu; Jean-Philippe Pin; Jianhua Cao; Philippe Rondard
Interdomain movements in metabotropic glutamate receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):15480-5.
2011: Laëtitia Comps-Agrar; Thierry Durroux; Martin Gassmann; Nathalie Gregor; Julie Kniazeff; Damien Maurel; Lenea Nørskov-Lauritsen; Laurent Prézeau; Eric Trinquet; Bernhard Bettler; Jean-Philippe Pin
The oligomeric state sets GABA(B) receptor signalling efficacy.
The EMBO journal 2011;30(12):2336-49.
2011: Julie Kniazeff; Laurent Prézeau; Philippe Rondard; Jean-Philippe Pin; Cyril Goudet
Dimers and beyond: The functional puzzles of class C GPCRs.
Pharmacology & therapeutics 2011;130(1):9-25.
2011: Lucie P Pellissier; Gaël Barthet; Florence Gaven; Elisabeth Cassier; Eric Trinquet; Jean-Philippe Pin; Philippe Marin; Aline Dumuis; Joël Bockaert; Jean-Louis Banères; Sylvie Claeysen
G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.
The Journal of biological chemistry 2011;286(12):9985-97.
2011: Carine Monnier; Haijun Tu; Emmanuel Bourrier; Claire Vol; Laurent Lamarque; Eric Trinquet; Jean-Philippe Pin; Philippe Rondard
Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation.
The EMBO journal 2011;30(1):32-42.
2011: Christo Christov; Patricia González-Bulnes; Fanny Malhaire; Tatyana Karabencheva; Cyril Goudet; Jean-Philippe Pin; Amadeu Llebaria; Jesús Giraldo
Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.
ChemMedChem 2011;6(1):131-40.
2011: Laëtitia Comps-Agrar; Damien Maurel; Jean-Philippe Pin; Philippe Rondard; Eric Trinquet; Laurent Prézeau
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to G protein-coupled receptor oligomerization.
Methods in molecular biology (Clifton, N.J.) 2011;756():201-14.
2011: Martin Cottet; Laura Albizu; Laetitia Comps-Agrar; Bernard Mouillac; Jean-Philippe Pin; Eric Trinquet; Thierry Durroux
Time resolved FRET strategy with fluorescent ligands to analyze receptor interactions in native tissues: application to GPCR oligomerization.
Methods in molecular biology (Clifton, N.J.) 2011;746():373-87.
2011: Etienne Doumazane; Pauline Scholler; Jurriaan M Zwier; Philippe Rondard; Eric Trinquet; Jean-Philippe Pin
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(1):66-77.
2011: Philippe Rondard; Cyril Goudet; Julie Kniazeff; Jean-Philippe Pin; Laurent Prézeau
The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors.
Neuropharmacology 2011;60(1):82-92.
2011: Francine Acher; Chelliah Selvam; Jean-Philippe Pin; Cyril Goudet; Hugues-Olivier BERTRAND
A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design.
Neuropharmacology 2011;60(1):102-7.
2010: Mohammed Akli Ayoub; Eric Trinquet; Kevin D G Pfleger; Jean-Philippe Pin
Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(9):3522-35.
2010: Laura Albizu; Martin Cottet; Michaela Kralikova; Stoytcho Stoev; René Seyer; Isabelle Brabet; Thomas Roux; Hervé Bazin; Emmanuel Bourrier; Laurent Lamarque; Christophe Breton; Marie-Laure Rives; Amy Newman; Jonathan A Javitch; Eric Trinquet; Maurice Manning; Jean-Philippe Pin; Bernard Mouillac; Thierry Durroux
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.
Nature chemical biology 2010;6(8):587-94.
2010: Chelliah Selvam; Nadia Oueslati; Isabelle A Lemasson; Isabelle Brabet; Delphine Rigault; Tiphanie Courtiol; Sara Cesarini; Nicolas Triballeau; Hugues-Olivier BERTRAND; Cyril Goudet; Jean-Philippe Pin; Francine Acher
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.
Journal of medicinal chemistry 2010;53(7):2797-813.
2010: Laurent Prezeau; Marie-Laure Rives; Laëtitia Comps-Agrar; Damien Maurel; Julie Kniazeff; Jean-Philippe Pin
Functional crosstalk between GPCRs: with or without oligomerization.
Current opinion in pharmacology 2010;10(1):6-13.
2010: Haijun Tu; Chanjuan Xu; Wenhua Zhang; Qiuyao Liu; Philippe Rondard; Jean-Philippe Pin; jianfeng Liu
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(2):749-59.
2010: xavier Rovira; Jean-Philippe Pin; Jesús Giraldo
The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways.
Trends in pharmacological sciences 2010;31(1):15-21.
2009: Jean-Philippe Pin; L Comps-Agrar; D Maurel; C Monnier; M L Rives; Eric Trinquet; J Kniazeff; P Rondard; Laurent Prézeau
G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABAB receptors.
The Journal of physiology 2009;587(Pt 22):5337-44.
2009: Mohammed Akli Ayoub; Marjorie Damian; Christian Gespach; Eric Ferrandis; Olivier Lavergne; Olivier De Wever; Jean-Louis Banères; Jean-Philippe Pin; Grégoire Pierre Prévost
Inhibition of heterotrimeric G protein signaling by a small molecule acting on Galpha subunit.
The Journal of biological chemistry 2009;284(42):29136-45.
2009: Marie-Laure Rives; Claire Vol; Yugo Fukazawa; Norbert Tinel; Eric Trinquet; Mohammed Akli Ayoub; Ryuichi Shigemoto; Jean-Philippe Pin; Laurent Prézeau
Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration.
The EMBO journal 2009;28(15):2195-208.
2009: Arnaud Ahier; Philippe Rondard; Nadège Gouignard; Naji Khayath; Siluo Huang; Jacques Trolet; Daniel J Donoghue; Monique Gauthier; Jean-Philippe Pin; Colette Dissous
A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids.
PloS one 2009;4(5):e5651.
2008: Jiri Kumpost; Zdenka Syrova; Lenka Kulihova; Daniela Frankova; Jean-Charles Bologna; Veronika Hlavackova; Laurent Prezeau; Michaela Kralikova; Bohdana Hruskova; Jean-Philippe Pin; Jaroslav Blahos
Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells.
Neuropharmacology 2008;55(4):409-18.
2008: Damien Maurel; Laëtitia Comps-Agrar; Carsten Brock; Marie-Laure Rives; Emmanuel Bourrier; Mohammed Akli Ayoub; Hervé Bazin; Norbert Tinel; Thierry Durroux; Laurent Prézeau; Eric Trinquet; Jean-Philippe Pin
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization.
Nature methods 2008;5(6):561-7.
2008: Philippe Rondard; Siluo Huang; Carine Monnier; Haijun Tu; Bertrand Blanchard; Nadia Oueslati; Fanny Malhaire; Ying Li; Eric Trinquet; Gilles Labesse; Jean-Philippe Pin; jianfeng Liu
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.
The EMBO journal 2008;27(9):1321-32.
2008: xavier Rovira; David Roche; Juan Serra; Julie Kniazeff; Jean-Philippe Pin; Jesús Giraldo
Modeling the binding and function of metabotropic glutamate receptors.
The Journal of pharmacology and experimental therapeutics 2008;325(2):443-56.
2008: Yelin Chen; Cyril Goudet; Jean-Philippe Pin; P Jeffrey Conn
N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
Molecular pharmacology 2008;73(3):909-18.
2007: Carsten Brock; Nadia Oueslati; Stéphan Soler; Laure Boudier; Philippe Rondard; Jean-Philippe Pin
Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement.
The Journal of biological chemistry 2007;282(45):33000-8.
2007: Chelliah Selvam; Cyril Goudet; Nadia Oueslati; Jean-Philippe Pin; Francine Acher
L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.
Journal of medicinal chemistry 2007;50(19):4656-64.
2007: Haijun Tu; Philippe Rondard; Chanjuan Xu; Federica Bertaso; Fangli Cao; Xueying Zhang; Jean-Philippe Pin; jianfeng Liu
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons.
Cellular signalling 2007;19(9):1996-2002.
2007: Pauline Sibille; Sébastien Lopez; Isabelle Brabet; Ornella Valenti; Nadia Oueslati; Florence Gaven; Cyril Goudet; Hugues-Olivier BERTRAND; Jacques Neyton; Michael J Marino; Marianne Amalric; Jean-Philippe Pin; Francine Acher
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
Journal of medicinal chemistry 2007;50(15):3585-95.
2007: Yelin Chen; Yi Nong; Cyril Goudet; Kamondanai Hemstapat; Tomas de Paulis; Jean-Philippe Pin; P Jeffrey Conn
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Molecular pharmacology 2007;71(5):1389-98.
2007: Mohammed A Ayoub; Damien Maurel; Virginie Binet; Michel Fink; Laurent Prézeau; Herve Ansanay; Jean-Philippe Pin
Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.
Molecular pharmacology 2007;71(5):1329-40.
2007: Virginie Binet; Béatrice Duthey; Jennifer Lecaillon; Claire Vol; Julie Quoyer; Gilles Labesse; Jean-Philippe Pin; Laurent Prézeau
Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors.
The Journal of biological chemistry 2007;282(16):12154-63.
2007: Mélanie Frauli; Nadia Hubert; Stephan Schann; Nicolas Triballeau; Hugues-Olivier BERTRAND; Francine Acher; Pascal Neuville; Jean-Philippe Pin; Laurent Prézeau
Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism.
Molecular pharmacology 2007;71(3):704-12.
2006: Eric Trinquet; Michel Fink; Hervé Bazin; Florence Grillet; Fabrice Maurin; Emmanuel Bourrier; Herve Ansanay; Cédric Leroy; Audrey Michaud; Thierry Durroux; Damien Maurel; Fanny Malhaire; Cyril Goudet; Jean-Philippe Pin; Magali Naval; Olivier Hernout; Françoise Chrétien; Yves Chapleur; Gérard Mathis
D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.
Analytical biochemistry 2006;358(1):126-35.
2006: Laura Albizu; Marie-Noëlle Balestre; Christophe Breton; Jean-Philippe Pin; Maurice Manning; Bernard Mouillac; Claude Barberis; Thierry Durroux
Probing the existence of G protein-coupled receptor dimers by positive and negative ligand-dependent cooperative binding.
Molecular pharmacology 2006;70(5):1783-91.
2006: Christelle Masdeu; Hélène Faure; Josée Coulombe; Angèle Schoenfelder; André Mann; Isabelle Brabet; Jean-Philippe Pin; Elisabeth Traiffort; Martial Ruat
Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.
Biochemical and biophysical research communications 2006;349(2):471-9.
2006: Philippe Rondard; jianfeng Liu; Siluo Huang; Fanny Malhaire; Claire Vol; Alexia Pinault; Gilles Labesse; Jean-Philippe Pin
Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors.
The Journal of biological chemistry 2006;281(34):24653-61.
2006: Mélanie Frauli; Pascal Neuville; Claire Vol; Jean-Philippe Pin; Laurent Prézeau
Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors.
Neuropharmacology 2006;50(2):245-53.
2005: Carsten Brock; Laure Boudier; Damien Maurel; Jaroslav Blahos; Jean-Philippe Pin
Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3.
Molecular biology of the cell 2005;16(12):5572-8.
2005: Cyril Goudet; Julie Kniazeff; Veronika Hlavackova; Fanny Malhaire; Damien Maurel; Francine Acher; Jaroslav Blahos; Laurent Prézeau; Jean-Philippe Pin
Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.
The Journal of biological chemistry 2005;280(26):24380-5.
2005: Jean-Philippe Pin; Julie Kniazeff; jianfeng Liu; Virginie Binet; Cyril Goudet; Philippe Rondard; Laurent Prézeau
Allosteric functioning of dimeric class C G-protein-coupled receptors.
The FEBS journal 2005;272(12):2947-55.
2005: Nicolas Triballeau; Francine Acher; Isabelle Brabet; Jean-Philippe Pin; Hugues-Olivier BERTRAND
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.
Journal of medicinal chemistry 2005;48(7):2534-47.
2005: Veronika Hlavackova; Cyril Goudet; Julie Kniazeff; Alice Zikova; Damien Maurel; Claire Vol; Johana Trojanova; Laurent Prézeau; Jean-Philippe Pin; Jaroslav Blahos
Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR.
The EMBO journal 2005;24(3):499-509.
2004: Virginie Binet; Cyril Goudet; C Brajon; L Le Corre; Francine Acher; Jean-Philippe Pin; Laurent Prézeau
Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.
Biochemical Society transactions 2004;32(Pt 5):871-2.
2004: Jean-Philippe Pin; Julie Kniazeff; Virginie Binet; jianfeng Liu; Damien Maurel; Thierry Galvez; Béatrice Duthey; Michaela Kralikova; Jaroslav Blahos; Laurent Prézeau; Philippe Rondard
Activation mechanism of the heterodimeric GABA(B) receptor.
Biochemical pharmacology 2004;68(8):1565-72.
2004: Julie Kniazeff; Anne-Sophie Bessis; Damien Maurel; Herve Ansanay; Laurent Prézeau; Jean-Philippe Pin
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.
Nature structural & molecular biology 2004;11(8):706-13.
2004: Virginie Binet; Carole Brajon; Laurent Le Corre; Francine Acher; Jean-Philippe Pin; Laurent Prézeau
The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor.
The Journal of biological chemistry 2004;279(28):29085-91.
2004: Damien Maurel; Julie Kniazeff; Gérard Mathis; Eric Trinquet; Jean-Philippe Pin; Herve Ansanay
Cell surface detection of membrane protein interaction with homogeneous time-resolved fluorescence resonance energy transfer technology.
Analytical biochemistry 2004;329(2):253-62.
2004: Jean-Philippe Pin; Julie Kniazeff; Cyril Goudet; Anne-Sophie Bessis; jianfeng Liu; Thierry Galvez; Francine Acher; Philippe Rondard; Laurent Prézeau
The activation mechanism of class-C G-protein coupled receptors.
Biology of the cell / under the auspices of the European Cell Biology Organization 2004;96(5):335-42.
2004: jianfeng Liu; Damien Maurel; Sébastien Etzol; Isabelle Brabet; Herve Ansanay; Jean-Philippe Pin; Philippe Rondard
Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.
The Journal of biological chemistry 2004;279(16):15824-30.
2004: Christian Mitri; Marie-Laure Parmentier; Jean-Philippe Pin; Joël Bockaert; Yves Grau
Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects.
The Journal of biological chemistry 2004;279(10):9313-20.
2004: Julie Kniazeff; Pierre-Philippe Saintot; Cyril Goudet; jianfeng Liu; Annie Charnet; gilles guillon; Jean-Philippe Pin
Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(2):370-7.
2004: Cyril Goudet; Florence Gaven; Julie Kniazeff; Claire Vol; Jiangfeng Liu; Martin Cohen-Gonsaud; Francine Acher; Laurent Prézeau; Jean-Philippe Pin
Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):378-83.
2003: Michaela Kralikova; Jaroslav Blahos; Isabelle Brabet; jianfeng Liu; Bohdana Hruskova; Laurent Prézeau; Jean-Philippe Pin
The second intracellular loop of metabotropic glutamate receptors recognizes C termini of G-protein alpha-subunits.
The Journal of biological chemistry 2003;278(37):35063-70.
2003: Jean-Philippe Pin; Thierry Galvez; Laurent Prézeau
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
Pharmacology & therapeutics 2003;98(3):325-54.
2003: Thierry Galvez; Jean-Philippe Pin
[How do G-protein-coupled receptors work? The case of metabotropic glutamate and GABA receptors].
Médecine sciences : M/S 2003;19(5):559-65.
2003: Lawrence Fourgeaud; Anne-Sophie Bessis; Françoise Rossignol; Jean-Philippe Pin; Jean-Christophe Olivo-Marin; Agnès Hémar
The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway.
The Journal of biological chemistry 2003;278(14):12222-30.
2003: Anne-Sophie Bessis; G Vadesne; E Bourrat; Gildas Bertho; Jean-Philippe Pin; Francine Acher
3-carboxy-4-phosphonocyclopentane amino acids: new metabotropic glutamate receptor ligands.
Amino acids 2003;24(3):303-10.
2002: Julie Kniazeff; Thierry Galvez; Gilles Labesse; Jean-Philippe Pin
No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(17):7352-61.
2002: Anne-Sophie Bessis; Philippe Rondard; Florence Gaven; Isabelle Brabet; Nicolas Triballeau; Laurent Prezeau; Francine Acher; Jean-Philippe Pin
Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11097-102.
2002: Michaela Kralikova; Laurent Prezeau; Béatrice Duthey; Bernhard Bettler; Jean-Philippe Pin; Jaroslav Blahos
The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor.
Molecular pharmacology 2002;62(2):343-50.
2002: Hugues-Olivier BERTRAND; Anne-Sophie Bessis; Jean-Philippe Pin; Francine Acher
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.
Journal of medicinal chemistry 2002;45(15):3171-83.
2002: Julie Perroy; Oussama El Far; Federica Bertaso; Jean-Philippe Pin; Heinrich Betz; Joël Bockaert; Laurent Fagni
PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7.
The EMBO journal 2002;21(12):2990-9.
2002: Fabrice Ango; David Robbe; Jian Cheng Tu; BO XIAO; Paul F Worley; Jean-Philippe Pin; Joël Bockaert; Laurent Fagni
Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons.
Molecular and cellular neurosciences 2002;20(2):323-9.
2002: Marie-Laure Parmentier; Laurent Prézeau; Joël Bockaert; Jean-Philippe Pin
A model for the functioning of family 3 GPCRs.
Trends in pharmacological sciences 2002;23(6):268-74.
2002: Béatrice Duthey; Sara Caudron; Julie Perroy; Bernhard Bettler; Laurent Fagni; Jean-Philippe Pin; Laurent Prézeau
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.
The Journal of biological chemistry 2002;277(5):3236-41.
2001: Julie Perroy; G J Gutierrez; V Coulon; Joël Bockaert; Jean-Philippe Pin; Laurent Fagni
The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways.
The Journal of biological chemistry 2001;276(49):45800-5.
2001: Jean-Philippe Pin; M L Parmentier; Laurent Prézeau
Positive allosteric modulators for gamma-aminobutyric acid(B) receptors open new routes for the development of drugs targeting family 3 G-protein-coupled receptors.
Molecular pharmacology 2001;60(5):881-4.
2001: Fabrice Ango; Laurent Prézeau; T Muller; Jian Cheng Tu; BO XIAO; Paul F Worley; Jean-Philippe Pin; Joël Bockaert; Laurent Fagni
Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.
Nature 2001;411(6840):962-5.
2001: Anne-Sophie Bessis; J Bolte; Jean-Philippe Pin; Francine Acher
New probes of the agonist binding site of metabotropic glutamate receptors.
Bioorganic & medicinal chemistry letters 2001;11(12):1569-72.
2001: Thierry Galvez; Béatrice Duthey; Julie Kniazeff; Jaroslav Blahos; Giorgio Rovelli; Bernhard Bettler; Laurent Prézeau; Jean-Philippe Pin
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function.
The EMBO journal 2001;20(9):2152-9.
2001: F Y Carroll; A Stolle; Philip M Beart; A Voerste; Isabelle Brabet; F Mauler; C Joly; H Antonicek; Joël Bockaert; T Müller; Jean-Philippe Pin; Laurent Prézeau
BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
Molecular pharmacology 2001;59(5):965-73.
2001: Jaroslav Blahos; T Fischer; Isabelle Brabet; Daniela Stauffer; Giorgio Rovelli; Joël Bockaert; Jean-Philippe Pin
A novel site on the Galpha -protein that recognizes heptahelical receptors.
The Journal of biological chemistry 2001;276(5):3262-9.
2001: Gabriele Costantino; K Maltoni; Maura Marinozzi; Emidio Camaioni; Laurent Prezeau; Jean-Philippe Pin; Roberto Pellicciari
Synthesis and biological evaluation of 2-(3'-(1H-tetrazol-5-yl) bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 receptor antagonist.
Bioorganic & medicinal chemistry 2001;9(2):221-7.
2000: Thierry Galvez; Laurent Prezeau; G Milioti; M Franek; C Joly; Wolfgang Froestl; Bernhard Bettler; Hugues-Olivier BERTRAND; Jaroslav Blahos; Jean-Philippe Pin
Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors.
The Journal of biological chemistry 2000;275(52):41166-74.
2000: Fabrice Ango; Jean-Philippe Pin; Jian Cheng Tu; BO XIAO; Paul F Worley; Joël Bockaert; Laurent Fagni
Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(23):8710-6.
2000: Anne-Sophie Bessis; Hugues-Olivier BERTRAND; Thierry Galvez; Cyril De Colle; Jean-Philippe Pin; Francine Acher
Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation process.
Protein science : a publication of the Protein Society 2000;9(11):2200-9.
2000: A Pagano; D Ruegg; S Litschig; Natacha Stoehr; Christine Stierlin; Micheline Heinrich; P Floersheim; L Prezèau; F Carroll; Jean-Philippe Pin; A Cambria; Ivo Vranesic; Peter J Flor; Fabrizio Gasparini; Rainer Kuhn
The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors.
The Journal of biological chemistry 2000;275(43):33750-8.
2000: Marie-Laure Parmentier; Thierry Galvez; Francine Acher; B Peyre; R Pellicciari; Yves Grau; Joël Bockaert; Jean-Philippe Pin
Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution.
Neuropharmacology 2000;39(7):1119-31.
2000: Cyril De Colle; Anne-Sophie Bessis; Joël Bockaert; Francine Acher; Jean-Philippe Pin
Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor.
European journal of pharmacology 2000;394(1):17-26.
2000: Thierry Galvez; Stephan Urwyler; Laurent Prézeau; Johannes Mosbacher; C Joly; Barbara Malitschek; Jakob Heid; Isabelle Brabet; Wolfgang Froestl; Bernhard Bettler; Klemens Kaupmann; Jean-Philippe Pin
Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit.
Molecular pharmacology 2000;57(3):419-26.
2000: Philippe Dauban; C de Saint-Fuscien; Francine Acher; Laurent Prézeau; Isabelle Brabet; Jean-Philippe Pin; Robert H Dodd
First enantiospecific synthesis of a 3,4-dihydroxy-L-glutamic acid [(3S,4S)-DHGA], a new mGluR1 agonist.
Bioorganic & medicinal chemistry letters 2000;10(2):129-33.
1999: M Franek; A Pagano; Klemens Kaupmann; Bernhard Bettler; Jean-Philippe Pin; Jaroslav Blahos
The heteromeric GABA-B receptor recognizes G-protein alpha subunit C-termini.
Neuropharmacology 1999;38(11):1657-66.
1999: Mireille Lafon-Cazal; G Viennois; Rainer Kuhn; Barbara Malitschek; Jean-Philippe Pin; Ryuichi Shigemoto; Joël Bockaert
mGluR7-like receptor and GABA(B) receptor activation enhance neurotoxic effects of N-methyl-D-aspartate in cultured mouse striatal GABAergic neurones.
Neuropharmacology 1999;38(10):1631-40.
1999: Anne-Sophie Bessis; N Jullian; E Coudert; Jean-Philippe Pin; Francine Acher
Extended glutamate activates metabotropic receptor types 1, 2 and 4: selective features at mGluR4 binding site.
Neuropharmacology 1999;38(10):1543-51.
1999: T Pfaff; Barbara Malitschek; Klemens Kaupmann; Laurent Prézeau; Jean-Philippe Pin; Bernhard Bettler; Andreas Karschin
Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptor.
The European journal of neuroscience 1999;11(8):2874-82.
1999: Barbara Malitschek; C Schweizer; MJ Keir; Jakob Heid; Wolfgang Froestl; Johannes Mosbacher; Rainer Kuhn; J Henley; C Joly; Jean-Philippe Pin; Klemens Kaupmann; Bernhard Bettler
The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.
Molecular pharmacology 1999;56(2):448-54.
1999: Jean-Philippe Pin; Cyril De Colle; Anne-Sophie Bessis; Francine Acher
New perspectives for the development of selective metabotropic glutamate receptor ligands.
European journal of pharmacology 1999;375(1-3):277-94.
1999: Fabrice Ango; S Albani-Torregrossa; C Joly; D Robbe; JM Michel; Jean-Philippe Pin; Joël Bockaert; Laurent Fagni
A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells.
Neuropharmacology 1999;38(6):793-803.
1999: Thierry Galvez; Marie-Laure Parmentier; C Joly; Barbara Malitschek; Klemens Kaupmann; Rainer Kuhn; Helmut Bittiger; Wolfgang Froestl; Bernhard Bettler; Jean-Philippe Pin
Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding.
The Journal of biological chemistry 1999;274(19):13362-9.
1999: N Jullian; Isabelle Brabet; Jean-Philippe Pin; Francine Acher
Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.
Journal of medicinal chemistry 1999;42(9):1546-55.
1999: S Litschig; Fabrizio Gasparini; D Rueegg; Natacha Stoehr; Peter J Flor; Ivo Vranesic; Laurent Prézeau; Jean-Philippe Pin; C Thomsen; Rainer Kuhn
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.
Molecular pharmacology 1999;55(3):453-61.
1999: Mireille Lafon-Cazal; Laurent Fagni; M J Guiraud; S Mary; Mireille Lerner-Natoli; Jean-Philippe Pin; Ryuichi Shigemoto; Joël Bockaert
mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.
The European journal of neuroscience 1999;11(2):663-72.
1998: Corrado Corti; Sophie Restituito; J M Rimland; Isabelle Brabet; Mauro Corsi; Jean-Philippe Pin; Francesco Ferraguti
Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8.
The European journal of neuroscience 1998;10(12):3629-41.
1998: Jaroslav Blahos; S Mary; Julie Perroy; Cyril De Colle; Isabelle Brabet; Joël Bockaert; Jean-Philippe Pin
Extreme C terminus of G protein alpha-subunits contains a site that discriminates between Gi-coupled metabotropic glutamate receptors.
The Journal of biological chemistry 1998;273(40):25765-9.
1998: Isabelle Brabet; Marie-Laure Parmentier; Cyril De Colle; Joël Bockaert; Francine Acher; Jean-Philippe Pin
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Neuropharmacology 1998;37(8):1043-51.
1998: Roberto Pellicciari; Gabriele Costantino; E Giovagnoni; L Mattoli; Isabelle Brabet; Jean-Philippe Pin
Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.
Bioorganic & medicinal chemistry letters 1998;8(12):1569-74.
1998: Marie-Laure Parmentier; C Joly; Sophie Restituito; Joël Bockaert; Yves Grau; Jean-Philippe Pin
The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain.
Molecular pharmacology 1998;53(4):778-86.
1998: F Tellier; Francine Acher; Isabelle Brabet; Jean-Philippe Pin; Robert Azerad
Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2.
Bioorganic & medicinal chemistry 1998;6(2):195-208.
1998: S Mary; J Gomeza; Laurent Prézeau; Joël Bockaert; Jean-Philippe Pin
A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C.
The Journal of biological chemistry 1998;273(1):425-32.
1998: Brian McCool; Jean-Philippe Pin; Michael M Harpold; Paul F Brust; Kenneth A Stauderman; David M Lovinger
Rat group I metabotropic glutamate receptors inhibit neuronal Ca2+ channels via multiple signal transduction pathways in HEK 293 cells.
Journal of neurophysiology 1998;79(1):379-91.
1997: S Mary; D Stephan; J Gomeza; Joël Bockaert; Rebecca PRUSS; Jean-Philippe Pin
The rat mGlu1d receptor splice variant shares functional properties with the other short isoforms of mGlu1 receptor.
European journal of pharmacology 1997;335(1):65-72.
1997: Francine Acher; F J Tellier; Robert Azerad; Isabelle Brabet; L Fagni; Jean-Philippe Pin
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.
Journal of medicinal chemistry 1997;40(19):3119-29.
1997: N Todeschi; Josyane Gharbi-Benarous; Francine Acher; V Larue; Jean-Philippe Pin; J Bockaert; Robert Azerad; Jean-Pierre Girault
Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists.
Bioorganic & medicinal chemistry 1997;5(2):335-52.
1996: J Gomeza; S Mary; Isabelle Brabet; Marie-Laure Parmentier; Sophie Restituito; J Bockaert; Jean-Philippe Pin
Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.
Molecular pharmacology 1996;50(4):923-30.
1996: Peter J Flor; J Gomeza; M A Tones; Rainer Kuhn; Jean-Philippe Pin; T Knöpfel
The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists.
Journal of neurochemistry 1996;67(1):58-63.
1996: Laurent Prézeau; J Gomeza; S Ahern; S Mary; T Galvez; J Bockaert; Jean-Philippe Pin
Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity.
Molecular pharmacology 1996;49(3):422-9.
1996: J Gomeza; C Joly; Rainer Kuhn; T Knöpfel; J Bockaert; Jean-Philippe Pin
The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins.
The Journal of biological chemistry 1996;271(4):2199-205.
1995: Isabelle Brabet; S Mary; J Bockaert; Jean-Philippe Pin
Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses.
Neuropharmacology 1995;34(8):895-903.
1995: C Joly; J Gomeza; Isabelle Brabet; K Curry; J Bockaert; Jean-Philippe Pin
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 2):3970-81.
1995: Jean-Philippe Pin; J Gomeza; C Joly; J Bockaert
The metabotropic glutamate receptors: their second intracellular loop plays a critical role in the G-protein coupling specificity.
Biochemical Society transactions 1995;23(1):91-6.
1994: Laurent Prézeau; J Carrette; B Helpap; K Curry; Jean-Philippe Pin; J Bockaert
Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures.
Molecular pharmacology 1994;45(4):570-7.
1994: Jean-Philippe Pin; C Joly; S F Heinemann; J Bockaert
Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors.
The EMBO journal 1994;13(2):342-8.
1992: Mireille Lafon-Cazal; I Bougault; Régis Steinberg; Jean-Philippe Pin; J Bockaert
Measurement of gamma-enolase release, a new method for selective quantification of neurotoxicity independently from glial lysis.
Brain research 1992;593(1):63-8.
1992: Lucia Tapia-Arancibia; Florence Rage; M Récasens; Jean-Philippe Pin
NMDA receptor activation stimulates phospholipase A2 and somatostatin release from rat cortical neurons in primary cultures.
European journal of pharmacology 1992;225(3):253-62.
1992: F Sladeczek; Olivier Jacques MANZONI; Laurent Fagni; Aline Dumuis; Jean-Philippe Pin; Michèle Sebben; J Bockaert
The metabotropic glutamate receptor (MGR): pharmacology and subcellular location.
Journal of physiology, Paris 1992;86(1-3):47-55.
1991: Florence Rage; Jean-Philippe Pin; Lucia Tapia-Arancibia
Phospholipase A and Somatostatin Release are Activated in Response to N-Methyl-D-Aspartate Receptor Stimulation in Hypothalamic Neurons in Primary Culture.
Journal of neuroendocrinology 1991;3(5):515-22.
1990: N Charpentier; Aline Dumuis; Michèle Sebben; J Bockaert; Jean-Philippe Pin
On concanavalin A-treated striatal neurons quisqualate clearly behaves as a partial agonist of a receptor fully activated by kainate.
European journal of pharmacology 1990;189(4-5):241-51.
1990: Aline Dumuis; Jean-Philippe Pin; K Oomagari; Michèle Sebben; J Bockaert
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors.
Nature 1990;347(6289):182-4.
1990: Olivier Jacques MANZONI; Laurent Fagni; Jean-Philippe Pin; F Rassendren; F Poulat; F Sladeczek; J Bockaert
(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes.
Molecular pharmacology 1990;38(1):1-6.
1990: F A Rassendren; Philippe Lory; Jean-Philippe Pin; Joël Nargeot
Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes.
Neuron 1990;4(5):733-40.
1990: J Bockaert; Aline Dumuis; Olivier Jacques MANZONI; J Nargeot; K Oomagari; Jean-Philippe Pin; F Rassendren; Michèle Sebben; F Sladeczek
Intracellular messengers associated with excitatory amino acid (EAA) receptors.
Advances in experimental medicine and biology 1990;268():79-91.
1989: F A Rassendren; Philippe Lory; Jean-Philippe Pin; J Bockaert; Joël Nargeot
A specific quisqualate agonist inhibits kainate responses induced in Xenopus oocytes injected with rat brain RNA.
Neuroscience letters 1989;99(3):333-9.
1989: B J Van Vliet; Michèle Sebben; Aline Dumuis; Jacqueline Gabrion; J Bockaert; Jean-Philippe Pin
Endogenous amino acid release from cultured cerebellar neuronal cells: effect of tetanus toxin on glutamate release.
Journal of neurochemistry 1989;52(4):1229-39.
1989: Jean-Philippe Pin; B J Van Vliet; J Bockaert
Complex interaction between quisqualate and kainate receptors as revealed by measurement of GABA release from striatal neurons in primary culture.
European journal of pharmacology 1989;172(1):81-91.
1989: Jean-Philippe Pin; J Bockaert
Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(2):648-56.
1988: Aline Dumuis; Michèle Sebben; L Haynes; Jean-Philippe Pin; J Bockaert
NMDA receptors activate the arachidonic acid cascade system in striatal neurons.
Nature 1988;336(6194):68-70.
1988: N Pares-Herbuté; A Bonet; S Peraldi; Jean-Philippe Pin; Jacqueline Gabrion; H Astier; Lucia Tapia-Arancibia
The presence of non-neuronal cells influences somatostatin release from cultured cerebral cortical cells.
Brain research 1988;468(1):89-97.
1988: Jean-Philippe Pin; B J Van-Vliet; J Bockaert
NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: differential blocking by phencyclidine.
Neuroscience letters 1988;87(1-2):87-92.
1985: F Sladeczek; Jean-Philippe Pin; M Récasens; J Bockaert; S Weiss
Glutamate stimulates inositol phosphate formation in striatal neurones.
Nature 1985;317(6039):717-9.