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Jerome Pinkner
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Network (preview)
48
Hultgren, Scott
9
Almqvist, Fredrik
7
Kihlberg, Jan
7
Waksman, Gabriel
7
Langermann, Solomon
6
Jones, CH
6
Hedenström, Mattias
5
Knight, Stefan
4
Frieden, Carl
4
Emtenäs, Hans
4
Sauer, Frederic
4
Auguste, Gale
3
Choudhury, Devapriya
3
Palaszynski, Susan
3
Burlein, Jeanne
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Geonetwork of Jerome Pinkner (preview)
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All Publications
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2009: Cegelski Lynette; Pinkner Jerome S; Hammer Neal D; Cusumano Corinne K; Hung Chia S; Chorell Erik; Aberg Veronica; Walker Jennifer N; Seed Patrick C; Almqvist Fredrik; Chapman Matthew R; Hultgren Scott J
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.
Nature chemical biology 2009;5(12):913-9.
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2009: Kostakioti Maria; Hadjifrangiskou Maria; Pinkner Jerome S; Hultgren Scott J
QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.
Molecular microbiology 2009;73(6):1020-31.
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2009: Kline Kimberly A; Kau Andrew L; Chen Swaine L; Lim Adeline; Pinkner Jerome S; Rosch Jason; Nallapareddy Sreedhar R; Murray Barbara E; Henriques-Normark Birgitta; Beatty Wandy; Caparon Michael G; Hultgren Scott J
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis.
Journal of bacteriology 2009;191(10):3237-47.
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2009: Henderson Jeffrey P; Crowley Jan R; Pinkner Jerome S; Walker Jennifer N; Tsukayama Pablo; Stamm Walter E; Hooton Thomas M; Hultgren Scott J
Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli.
PLoS pathogens 2009;5(2):e1000305.
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2008: Rosen David A; Pinkner Jerome S; Walker Jennifer N; Elam Jennifer Stine; Jones Jennifer M; Hultgren Scott J
Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract.
Infection and immunity 2008;76(7):3346-56.
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2008: Rosen David A; Pinkner Jerome S; Jones Jennifer M; Walker Jennifer N; Clegg Steven; Hultgren Scott J
Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression.
Infection and immunity 2008;76(7):3337-45.
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2008: Berg Veronica; Das Pralay; Chorell Erik; Hedenström Mattias; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik
Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli.
Bioorganic & medicinal chemistry letters 2008;18(12):3536-40.
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2008: Remaut Han; Tang Chunyan; Henderson Nadine S; Pinkner Jerome S; Wang Tao; Hultgren Scott J; Thanassi David G; Waksman Gabriel; Li Huilin
Fiber formation across the bacterial outer membrane by the chaperone/usher pathway.
Cell 2008;133(4):640-52.
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2008: Hannan Thomas J; Mysorekar Indira U; Chen Swaine L; Walker Jennifer N; Jones Jennifer M; Pinkner Jerome S; Hultgren Scott J; Seed Patrick C
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis.
Molecular microbiology 2008;67(1):116-28.
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2006: Pinkner Jerome S; Remaut Han; Buelens Floris; Miller Eric; Aberg Veronica; Pemberton Nils; Hedenström Mattias; Larsson Andreas; Seed Patrick; Waksman Gabriel; Hultgren Scott J; Almqvist Fredrik
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17897-902.
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2006: Berg Veronica; Sellstedt Magnus; Hedenström Mattias; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik
Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-targeting virulence of uropathogenic E. coli.
Bioorganic & medicinal chemistry 2006;14(22):7563-81.
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2005: Meehl Michael A; Pinkner Jerome S; Anderson Patricia J; Hultgren Scott J; Caparon Michael G
A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase.
PLoS pathogens 2005;1(4):e35.
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2005: Isaac Daniel D; Pinkner Jerome S; Hultgren Scott J; Silhavy Thomas J
The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17775-9.
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2005: Hedenström Mattias; Emtenäs Hans; Pemberton Nils; Aberg Veronica; Hultgren Scott J; Pinkner Jerome S; Tegman Viola; Almqvist Fredrik; Sethson Ingmar; Kihlberg Jan
NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly.
Organic & biomolecular chemistry 2005;3(23):4193-200.
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2005: Justice Sheryl S; Hunstad David A; Harper Jill Reiss; Duguay Amy R; Pinkner Jerome S; Bann James; Frieden Carl; Silhavy Thomas J; Hultgren Scott J
Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli.
Journal of bacteriology 2005;187(22):7680-6.
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2005: Aberg Veronica; Hedenström Mattias; Pinkner Jerome S; Hultgren S J; Almqvist Fredrik
C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli.
Organic & biomolecular chemistry 2005;3(21):3886-92.
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2005: Ohlsson Jörgen; Larsson Andreas; Haataja Sauli; Alajääski Jenny; Stenlund Peter; Pinkner Jerome S; Hultgren Scott J; Finne Jukka; Kihlberg Jan; Nilsson Ulf J
Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins.
Organic & biomolecular chemistry 2005;3(5):886-900.
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2005: Larsson Andreas; Johansson Susanne M C; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik; Kihlberg Jan; Linusson Anna
Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli.
Journal of medicinal chemistry 2005;48(4):935-45.
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2005: Bouckaert Julie; Berglund Jenny; Schembri Mark; De Genst Erwin; Cools Lieve; Wuhrer Manfred; Hung Chia-Suei; Pinkner Jerome; Slättegård Rikard; Zavialov Anton; Choudhury Devapriya; Langermann Solomon; Hultgren Scott J; Wyns Lode; Klemm Per; Oscarson Stefan; Knight Stefan D; De Greve Henri
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin.
Molecular microbiology 2005;55(2):441-55.
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2004: Bann James G; Pinkner Jerome S; Frieden Carl; Hultgren Scott J
Catalysis of protein folding by chaperones in pathogenic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17389-93.
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2004: Roberts James A; Kaack M Bernice; Baskin Gary; Chapman Matthew R; Hunstad David A; Pinkner Jerome S; Hultgren Scott J
Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein.
The Journal of urology 2004;171(4):1682-5.
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2004: Sexton Jessica A; Pinkner Jerome S; Roth Robyn; Heuser John E; Hultgren Scott J; Vogel Joseph P
The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth.
Journal of bacteriology 2004;186(6):1658-66.
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2003: Barnhart Michelle M; Sauer Frederic G; Pinkner Jerome S; Hultgren Scott J
Chaperone-subunit-usher interactions required for donor strand exchange during bacterial pilus assembly.
Journal of bacteriology 2003;185(9):2723-30.
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2003: Emtenäs Hans; Carlsson Marcus; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik
Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria.
Organic & biomolecular chemistry 2003;1(8):1308-14.
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2002: Sauer Frederic G; Pinkner Jerome S; Waksman Gabriel; Hultgren Scott J
Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation.
Cell 2002;111(4):543-51.
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2002: Emtenäs Hans; Ahlin Kristoffer; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik
Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria.
Journal of combinatorial chemistry 2002;4(6):630-9.
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2002: Knight Stefan D; Choudhury Devapriya; Hultgren Scott; Pinkner Jerome; Stojanoff Vivian; Thompson Andrew
Structure of the S pilus periplasmic chaperone SfaE at 2.2 A resolution.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):1016-22.
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2002: Hung Chia-Suei; Bouckaert Julie; Hung Danielle; Pinkner Jerome; Widberg Charlotte; DeFusco Anthony; Auguste C Gale; Strouse Robert; Langermann Solomon; Waksman Gabriel; Hultgren Scott J
Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection.
Molecular microbiology 2002;44(4):903-15.
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2002: Chapman Matthew R; Robinson Lloyd S; Pinkner Jerome S; Roth Robyn; Heuser John; Hammar Marten; Normark Staffan; Hultgren Scott J
Role of Escherichia coli curli operons in directing amyloid fiber formation.
Science (New York, N.Y.) 2002;295(5556):851-5.
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2002: Bann James G; Pinkner Jerome; Hultgren Scott J; Frieden Carl
Real-time and equilibrium (19)F-NMR studies reveal the role of domain-domain interactions in the folding of the chaperone PapD.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):709-14.
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2001: Svensson A; Larsson A; Emtenäs H; Hedenström M; Fex T; Hultgren S J; Pinkner J S; Almqvist F; Kihlberg J
Design and evaluation of pilicides: potential novel antibacterial agents directed against uropathogenic Escherichia coli.
Chembiochem : a European journal of chemical biology 2001;2(12):915-8.
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2001: Dodson K W; Pinkner J S; Rose T; Magnusson G; Hultgren S J; Waksman G
Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell 2001;105(6):733-43.
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2000: Barnhart M M; Pinkner J S; Soto G E; Sauer F G; Langermann S; Waksman G; Frieden C; Hultgren S J
PapD-like chaperones provide the missing information for folding of pilin proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7709-14.
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2000: Martinez J J; Mulvey M A; Schilling J D; Pinkner J S; Hultgren S J
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells.
The EMBO journal 2000;19(12):2803-12.
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2000: Langermann S; Möllby R; Burlein J E; Palaszynski S R; Auguste C G; DeFusco A; Strouse R; Schenerman M A; Hultgren S J; Pinkner J S; Winberg J; Guldevall L; Söderhäll M; Ishikawa K; Normark S; Koenig S
Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli.
The Journal of infectious diseases 2000;181(2):774-8.
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1999: Choudhury D; Thompson A; Stojanoff V; Langermann S; Pinkner J; Hultgren S J; Knight S D
X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli.
Science (New York, N.Y.) 1999;285(5430):1061-6.
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1999: Sauer F G; Fütterer K; Pinkner J S; Dodson K W; Hultgren S J; Waksman G
Structural basis of chaperone function and pilus biogenesis.
Science (New York, N.Y.) 1999;285(5430):1058-61.
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1999: Hung D L; Pinkner J S; Knight S D; Hultgren S J
Structural basis of chaperone self-capping in P pilus biogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8178-83.
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1998: Karlsson K F; Walse B; Drakenberg T; Roy S; Bergquist K E; Pinkner J S; Hultgren S J; Kihlberg J
Binding of peptides in solution by the Escherichia coli chaperone PapD as revealed using an inhibition ELISA and NMR spectroscopy.
Bioorganic & medicinal chemistry 1998;6(11):2085-101.
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1998: Saulino E T; Thanassi D G; Pinkner J S; Hultgren S J
Ramifications of kinetic partitioning on usher-mediated pilus biogenesis.
The EMBO journal 1998;17(8):2177-85.
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1998: Palaszynski S; Pinkner J; Leath S; Barren P; Auguste C G; Burlein J; Hultgren S; Langermann S
Systemic immunization with conserved pilus-associated adhesins protects against mucosal infections.
Developments in biological standardization 1998;92():117-22.
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1997: Jones C H; Danese P N; Pinkner J S; Silhavy T J; Hultgren S J
The chaperone-assisted membrane release and folding pathway is sensed by two signal transduction systems.
The EMBO journal 1997;16(21):6394-406.
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1997: Walse B; Kihlberg J; Karlsson K F; Nilsson M; Wahlund K G; Pinkner J S; Hultgren S J; Drakenberg T
Transferred nuclear Overhauser effect spectroscopy study of a peptide from the PapG pilus subunit bound by the Escherichia coli PapD chaperone.
FEBS letters 1997;412(1):115-20.
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1997: Langermann S; Palaszynski S; Barnhart M; Auguste G; Pinkner J S; Burlein J; Barren P; Koenig S; Leath S; Jones C H; Hultgren S J
Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination.
Science (New York, N.Y.) 1997;276(5312):607-11.
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1997: Knight S; Mulvey M; Pinkner J
Crystallization and preliminary X-ray diffraction studies of the FimC-FimH chaperone-adhesin complex from Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 2):207-10.
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1996: Bullitt E; Jones C H; Striker R; Soto G; Jacob-Dubuisson F; Pinkner J; Wick M J; Makowski L; Hultgren S J
Development of pilus organelle subassemblies in vitro depends on chaperone uncapping of a beta zipper.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):12890-5.
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1996: St Geme J W; Pinkner J S; Krasan G P; Heuser J; Bullitt E; Smith A L; Hultgren S J
Haemophilus influenzae pili are composite structures assembled via the HifB chaperone.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11913-8.
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1996: Hung D L; Knight S D; Woods R M; Pinkner J S; Hultgren S J
Molecular basis of two subfamilies of immunoglobulin-like chaperones.
The EMBO journal 1996;15(15):3792-805.
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1995: Xu Z; Jones C H; Haslam D; Pinkner J S; Dodson K; Kihlberg J; Hultgren S J
Molecular dissection of PapD interaction with PapG reveals two chaperone-binding sites.
Molecular microbiology 1995;16(5):1011-20.
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1995: Jones C H; Pinkner J S; Roth R; Heuser J; Nicholes A V; Abraham S N; Hultgren S J
FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2081-5.
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1994: Jacob-Dubuisson F; Pinkner J; Xu Z; Striker R; Padmanhaban A; Hultgren S J
PapD chaperone function in pilus biogenesis depends on oxidant and chaperone-like activities of DsbA.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11552-6.
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1993: Jones C H; Pinkner J S; Nicholes A V; Slonim L N; Abraham S N; Hultgren S J
FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8397-401.
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1992: Slonim L N; Pinkner J S; Brändén C I; Hultgren S J
Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly.
The EMBO journal 1992;11(13):4747-56.
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