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James Pipas

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Sandlin P Seguin; Peter Wipf; Christine M Wright; Jason E Gestwicki; Tushar Gupta; Alex W Ireland; Yoshinari Miyata; James M Pipas; Jeffrey L Brodsky
A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.
Ping An; M Teresa Sáenz-Robles; James M Pipas
Large T antigens of polyomaviruses: amazing molecular machines.
Pamela L Wenzel; Jean-Leon Chong; M Teresa Sáenz-Robles; Antoney Ferrey; John Patrick Hagan; Yorman M Gomez; Ravi Rajmohan; Nidhi Sharma; Hui-Zi Chen; James M Pipas; Michael L Robinson; Gustavo Leone
Cell proliferation in the absence of E2F1-3.

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All Publications

2012: Sandlin P Seguin; Peter Wipf; Christine M Wright; Jason E Gestwicki; Tushar Gupta; Alex W Ireland; Yoshinari Miyata; James M Pipas; Jeffrey L Brodsky
A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.
Antiviral research 2012;96(1):70-81.
2012: Ping An; M Teresa Sáenz-Robles; James M Pipas
Large T antigens of polyomaviruses: amazing molecular machines.
Annual review of microbiology 2012;66():213-36.
2011: Pamela L Wenzel; Jean-Leon Chong; M Teresa Sáenz-Robles; Antoney Ferrey; John Patrick Hagan; Yorman M Gomez; Ravi Rajmohan; Nidhi Sharma; Hui-Zi Chen; James M Pipas; Michael L Robinson; Gustavo Leone
Cell proliferation in the absence of E2F1-3.
Developmental biology 2011;351(1):35-45.
2011: M Teresa Sáenz-Robles; Ashley Case; Jean-Leon Chong; Gustavo Leone; James M Pipas
The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway.
PloS one 2011;6(10):e26019.
2011: Paul G Cantalupo; Rosina Girones; Michael Grabe; Roger W Hendrix; Ayalkibet Hundesa; Josh P Katz; David Wang; Adam D Wier; Guoyan Zhao; Byron Calgua; James M Pipas
Raw sewage harbors diverse viral populations.
mBio 2011;2(5):.
2010: Abhilasha V Rathi; Paul G Cantalupo; Saumendra N Sarkar; James M Pipas
Induction of interferon-stimulated genes by Simian virus 40 T antigens.
Virology 2010;406(2):202-11.
2009: Jean-Leon Chong; Pamela L Wenzel; M Teresa Sáenz-Robles; Vivek Nair; Antoney Ferrey; John Patrick Hagan; Yorman M Gomez; Nidhi Sharma; Hui-Zi Chen; Madhu Ouseph; Shu-Huei Wang; Prashant Trikha; Brian Culp; Louise Mezache; Douglas J Winton; Owen J Sansom; Danian Chen; Rod Bremner; Paul G Cantalupo; Michael L Robinson; James M Pipas; Gustavo Leone
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.
Nature 2009;462(7275):930-4.
2009: Joy Loh; Guoyan Zhao; RM Presti; Lori R Holtz; Stacy R Finkbeiner; Lindsay Droit; Zoilmar Villasana; Collin Todd; James M Pipas; Byron Calgua; Rosina Girones; David Wang; Herbert W Virgin
Detection of novel sequences related to african Swine Fever virus in human serum and sewage.
Journal of virology 2009;83(24):13019-25.
2009: Abhilasha V Rathi; M Teresa Sáenz-Robles; Paul G Cantalupo; Robert H Whitehead; James M Pipas
Simian virus 40 T-antigen-mediated gene regulation in enterocytes is controlled primarily by the Rb-E2F pathway.
Journal of virology 2009;83(18):9521-31.
2009: Deepika Ahuja; Abhilasha V Rathi; Amy E Greer; Xiaojiang S Chen; James M Pipas
A structure-guided mutational analysis of simian virus 40 large T antigen: identification of surface residues required for viral replication and transformation.
Journal of virology 2009;83(17):8781-8.
2009: Maria Teresa Sáenz Robles; James M Pipas
T antigen transgenic mouse models.
Seminars in cancer biology 2009;19(4):229-35.
2009: Christine M Wright; Sandlin P Seguin; Sheara W Fewell; Haijiang Zhang; Chandra Ishwad; Abhay Vats; Clifford A Lingwood; Peter Wipf; Ellen Fanning; James M Pipas; Jeffrey L Brodsky
Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen.
Virus research 2009;141(1):71-80.
2009: Paul G Cantalupo; M Teresa Sáenz-Robles; Abhilasha V Rathi; Rebecca W Beerman; William H Patterson; Robert H Whitehead; James M Pipas
Cell-type specific regulation of gene expression by simian virus 40 T antigens.
Virology 2009;386(1):183-91.
2009: James M Pipas
SV40: Cell transformation and tumorigenesis.
Virology 2009;384(2):294-303.
2009: Lori R Holtz; Stacy R Finkbeiner; Guoyan Zhao; Carl D Kirkwood; Rosina Girones; James M Pipas; David Wang
Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread.
Virology journal 2009;6():86.
2008: Xiaorong Zhao; Ramiro J Madden-Fuentes; Becky X Lou; James M Pipas; Jeannine Gerhardt; Christopher J Rigell; Ellen Fanning
Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells.
Journal of virology 2008;82(11):5316-28.
2008: Christine M Wright; Raj J Chovatiya; Nora E Jameson; David M Turner; Guangyu Zhu; Stefan Werner; Donna M Huryn; James M Pipas; Billy W Day; Peter Wipf; Jeffrey L Brodsky
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.
Bioorganic & medicinal chemistry 2008;16(6):3291-301.
2007: M Teresa Sáenz-Robles; Jennifer A Markovics; Jean-Leon Chong; Rene Opavsky; Robert H Whitehead; Gustavo Leone; James M Pipas
Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2.
Journal of virology 2007;81(23):13191-9.
2007: Abhilasha V Rathi; M Teresa Sáenz-Robles; James M Pipas
Enterocyte proliferation and intestinal hyperplasia induced by simian virus 40 T antigen require a functional J domain.
Journal of virology 2007;81(17):9481-9.
2007: M Teresa Sáenz-Robles; David Toma; Paul Cantalupo; Jie Zhou; Gong Herbert; C Edwards; James M Pipas; Wen Xie
Repression of intestinal drug metabolizing enzymes by the SV40 large T antigen.
Oncogene 2007;26(35):5124-31.
2007: Christine M Wright; Sheara W Fewell; Mara L Sullivan; James M Pipas; simon simon watkins; Jeffrey L Brodsky
The Hsp40 molecular chaperone Ydj1p, along with the protein kinase C pathway, affects cell-wall integrity in the yeast Saccharomyces cerevisiae.
Genetics 2007;175(4):1649-64.
2006: Christopher S Sullivan; Adam Grundhoff; S Tevethia; R Treisman; James M Pipas; Don Ganem
Expression and function of microRNAs in viruses great and small.
Cold Spring Harbor symposia on quantitative biology 2006;71():351-6.
2005: Deepika Ahuja; M Teresa Sáenz-Robles; James M Pipas
SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.
Oncogene 2005;24(52):7729-45.
2005: Paul Cantalupo; Adrienne Doering; Christopher S Sullivan; Achintya Pal; Keith W C Peden; Andrew M Lewis; James M Pipas
Complete nucleotide sequence of polyomavirus SA12.
Journal of virology 2005;79(20):13094-104.
2005: Christopher S Sullivan; Adam Grundhoff; Satvir Tevethia; James M Pipas; Don Ganem
SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells.
Nature 2005;435(7042):682-6.
2005: Jennifer A Markovics; Patrick A Carroll; M Teresa Sáenz Robles; Hannah Pope; Craig M Coopersmith; James M Pipas
Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53.
Journal of virology 2005;79(12):7492-502.
2004: Christopher S Sullivan; A E Baker; James M Pipas
Simian virus 40 infection disrupts p130-E2F and p107-E2F complexes but does not perturb pRb-E2F complexes.
Virology 2004;320(2):218-28.
2003: Pierre Genevaux; Florence Lang; francoise schwager; Jai V Vartikar; Mary Kathleen Rundell; James M Pipas; Costa Georgopoulos; William L Kelley
Simian virus 40 T antigens and J domains: analysis of Hsp40 cochaperone functions in Escherichia coli.
Journal of virology 2003;77(19):10706-13.
2003: Laura R Chromy; James M Pipas; Robert L Garcea
Chaperone-mediated in vitro assembly of Polyomavirus capsids.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10477-82.
2002: Christopher S Sullivan; James M Pipas
T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis.
Microbiology and molecular biology reviews : MMBR 2002;66(2):179-202.
2002: Sheara W Fewell; James M Pipas; Jeffrey L Brodsky
Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2002-7.
2001: M Teresa Sáenz-Robles; Christopher S Sullivan; James M Pipas
Transforming functions of Simian Virus 40.
Oncogene 2001;20(54):7899-907.
2001: Christopher S Sullivan; James M Pipas
The virus-chaperone connection.
Virology 2001;287(1):1-8.
2001: K F Sachsenmeier; James M Pipas
Inhibition of Rb and p53 is insufficient for SV40 T-antigen transformation.
Virology 2001;283(1):40-8.
2001: James M Pipas; Arnold J Levine
Role of T antigen interactions with p53 in tumorigenesis.
Seminars in cancer biology 2001;11(1):23-30.
2001: Christopher S Sullivan; Susan P Gilbert; James M Pipas
ATP-dependent simian virus 40 T-antigen-Hsc70 complex formation.
Journal of virology 2001;75(4):1601-10.
2001: J D Tremblay; K F Sachsenmeier; James M Pipas
Propagation of wild-type and mutant SV40.
Methods in molecular biology (Clifton, N.J.) 2001;165():1-7.
2000: Christopher S Sullivan; Paul Cantalupo; James M Pipas
The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism.
Molecular and cellular biology 2000;20(17):6233-43.
2000: Christopher S Sullivan; J D Tremblay; Sheara W Fewell; J A Lewis; Jeffrey L Brodsky; James M Pipas
Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40.
Molecular and cellular biology 2000;20(15):5749-57.
1999: A Slinskey; D Barnes; James M Pipas
Simian virus 40 large T antigen J domain and Rb-binding motif are sufficient to block apoptosis induced by growth factor withdrawal in a neural stem cell line.
Journal of virology 1999;73(8):6791-9.
1999: Paul Cantalupo; M Teresa Sáenz-Robles; James M Pipas
Expression of SV40 large T antigen in baculovirus systems and purification by immunoaffinity chromatography.
Methods in enzymology 1999;306():297-307.
1998: F Higashino; James M Pipas; Thomas Shenk
Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15683-7.
1998: Jeffrey L Brodsky; James M Pipas
Polyomavirus T antigens: molecular chaperones for multiprotein complexes.
Journal of virology 1998;72(7):5329-34.
1998: James M Pipas
Molecular chaperone function of the SV40 large T antigen.
Developments in biological standardization 1998;94():313-9.
1998: Keith W C Peden; Alagarsamy Srinivasan; Jai V Vartikar; James M Pipas
Effects of mutations within the SV40 large T antigen ATPase/p53 binding domain on viral replication and transformation.
Virus genes 1998;16(2):153-65.
1998: C G Robinson; James M Pipas
SV40 large tumor antigen (T antigen): database of mutants.
Nucleic acids research 1998;26(1):295-6.
1997: A M Castellino; Paul Cantalupo; I M Marks; Jai V Vartikar; Keith W C Peden; James M Pipas
trans-Dominant and non-trans-dominant mutant simian virus 40 large T antigens show distinct responses to ATP.
Journal of virology 1997;71(10):7549-59.
1997: Alagarsamy Srinivasan; AJ McClellan; Jai V Vartikar; I Marks; Paul Cantalupo; Y Li; P Whyte; Mary Kathleen Rundell; Jeffrey L Brodsky; James M Pipas
The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.
Molecular and cellular biology 1997;17(8):4761-73.
1997: JJ Rushton; D Jiang; Alagarsamy Srinivasan; James M Pipas; Paul D Robbins
Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.
Journal of virology 1997;71(7):5620-3.
1996: T D Kierstead; James M Pipas
Database of mutations that alter the large tumor antigen in simian virus 40.
Nucleic acids research 1996;24(1):125-6.
1995: B S Collins; James M Pipas
T antigens encoded by replication-defective simian virus 40 mutants dl1135 and 5080.
The Journal of biological chemistry 1995;270(25):15377-84.
1995: S Okamoto; M Ohji; K Kosaku; Nirmala SundarRaj; John R Hassell; R A Thoft; James M Pipas
Characterization of immortalized rabbit corneal epithelial cells with SV40 large T antigen.
Japanese journal of ophthalmology 1995;39(4):323-33.
1994: S L Spence; James M Pipas
SV40 large T antigen functions at two distinct steps in virion assembly.
Virology 1994;204(1):200-9.
1994: S L Spence; James M Pipas
Simian virus 40 large T antigen host range domain functions in virion assembly.
Journal of virology 1994;68(7):4227-40.
1993: G G Finley; R A Koski; M F Melhem; James M Pipas; A I Meisler
Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma.
Cancer research 1993;53(12):2919-26.
1993: H S Symonds; Susan A McCarthy; Jiandong Chen; James M Pipas; Terry Van Dyke
Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant.
Molecular and cellular biology 1993;13(6):3255-65.
1993: D H Mack; Jai V Vartikar; James M Pipas; Laimonis A Laimins
Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.
Nature 1993;363(6426):281-3.
1993: James M Pipas; K Pogue-Geile; G G Finley; C A Cartwright; A I Meiesler
Gene structure and expression in colorectal cancer.
Advances in experimental medicine and biology 1993;330():67-75.
1992: M F Melhem; A I Meisler; G G Finley; W H Bryce; M O Jones; I I Tribby; James M Pipas; R A Koski
Distribution of cells expressing myc proteins in human colorectal epithelium, polyps, and malignant tumors.
Cancer research 1992;52(21):5853-64.
1992: James M Pipas
Common and unique features of T antigens encoded by the polyomavirus group.
Journal of virology 1992;66(7):3979-85.
1992: Jiandong Chen; G J Tobin; James M Pipas; Terry Van Dyke
T-antigen mutant activities in vivo: roles of p53 and pRB binding in tumorigenesis of the choroid plexus.
Oncogene 1992;7(6):1167-75.
1992: Keith W C Peden; James M Pipas
Simian virus 40 mutants with amino-acid substitutions near the amino terminus of large T antigen.
Virus genes 1992;6(2):107-18.
1991: K Pogue-Geile; J R Geiser; M Shu; C Miller; I G Wool; A I Meisler; James M Pipas
Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein.
Molecular and cellular biology 1991;11(8):3842-9.
1990: S L Spence; L C Tack; J H Wright; S Carswell; James M Pipas
Infection of CV1 cells expressing the polyoma virus middle T antigen or the SV40 agnogene product with simian virus 40 host-range mutants.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(6):604-11.
1990: Keith W C Peden; S L Spence; L C Tack; C A Cartwright; Alagarsamy Srinivasan; James M Pipas
A DNA replication-positive mutant of simian virus 40 that is defective for transformation and the production of infectious virions.
Journal of virology 1990;64(6):2912-21.
1989: Alagarsamy Srinivasan; Keith W C Peden; James M Pipas
The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.
Journal of virology 1989;63(12):5459-63.
1989: G G Finley; N T Schulz; S A Hill; J R Geiser; James M Pipas; A I Meisler
Expression of the myc gene family in different stages of human colorectal cancer.
Oncogene 1989;4(8):963-71.
1989: L C Tack; C A Cartwright; J H Wright; W Eckhart; Keith W C Peden; Alagarsamy Srinivasan; James M Pipas
Properties of a simian virus 40 mutant T antigen substituted in the hydrophobic region: defective ATPase and oligomerization activities and altered phosphorylation accompany an inability to complex with cellular p53.
Journal of virology 1989;63(8):3362-7.
1989: Christine A Cartwright; M P Kamps; A I Meisler; James M Pipas; W Eckhart
pp60c-src activation in human colon carcinoma.
The Journal of clinical investigation 1989;83(6):2025-33.
1989: Keith W C Peden; Alagarsamy Srinivasan; Joshua M Farber; James M Pipas
Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53.
Virology 1989;168(1):13-21.
1988: L A Hunter; James M Pipas
Isolation of a simian virus 40-simian agent 12 recombinant papovavirus that synthesizes a hybrid large tumour antigen.
The Journal of general virology 1988;69 ( Pt 3)():683-7.
1988: Kamel Khalili; J Brady; James M Pipas; S L Spence; Moshe J Sadofsky; G Khoury
Carboxyl-terminal mutants of the large tumor antigen of simian virus 40: a role for the early protein late in the lytic cycle.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):354-8.
1985: Keith W C Peden; James M Pipas
Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation.
Journal of virology 1985;55(1):1-9.
1983: R Clark; Keith W C Peden; James M Pipas; Daniel Nathans; Robert Tjian
Biochemical activities of T-antigen proteins encoded by simian virus 40 A gene deletion mutants.
Molecular and cellular biology 1983;3(2):220-8.
1983: K J Soprano; N Galanti; G J Jonak; S McKercher; James M Pipas; Keith W C Peden; R Baserga
Mutational analysis of simian virus 40 T antigen: stimulation of cellular DNA synthesis and activation of rRNA genes by mutants with deletions in the T-antigen gene.
Molecular and cellular biology 1983;3(2):214-9.
1983: James M Pipas; Keith W C Peden; Daniel Nathans
Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene.
Molecular and cellular biology 1983;3(2):203-13.
1980: Keith W C Peden; James M Pipas; Sonia Pearson-White; Daniel Nathans
Isolation of mutants of an animal virus in bacteria.
Science (New York, N.Y.) 1980;209(4463):1392-6.
1980: James M Pipas; S P Adler; Keith W C Peden; Daniel Nathans
Deletion mutants of SV40 that affect the structure of viral tumor antigens.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 1,():285-91.