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Munir Pirmohamed

Research Profile

Disorders

Occupations

Pharmacogenetics

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Single Nucleotide Polymorphism

Concepts & Ideas

Adverse Drug Reaction Reporting Systems

Anatomy

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Great Britain

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Mouse

Co-author Network

Publications

TOP 3
David Dickens; Andrew Owen; Ana Alfirevic; Munir Pirmohamed
ABCB1 single nucleotide polymorphisms (1236C>T, 2677G>T, and 3435C>T) do not affect transport activity of human P-glycoprotein.
David Dickens; Athina Giannoudis; S Samar Hasnain; Andrew Owen; Steffen Rädisch; Steven D Webb; Svetlana Antonyuk; Munir Pirmohamed
Transport of gabapentin by LAT1 (SLC7A5).
Catherine C Bell; John Farrell; Lee Faulkner; Klara Martinsson; Dean J Naisbitt; Munir Pirmohamed; Jonathan D Tugwood; Ana Alfirevic; B Kevin Park
T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms.

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All Publications

2013: David Dickens; Andrew Owen; Ana Alfirevic; Munir Pirmohamed
ABCB1 single nucleotide polymorphisms (1236C>T, 2677G>T, and 3435C>T) do not affect transport activity of human P-glycoprotein.
Pharmacogenetics and genomics 2013;23(6):314-23.
2013: David Dickens; Athina Giannoudis; S Samar Hasnain; Andrew Owen; Steffen Rädisch; Steven D Webb; Svetlana Antonyuk; Munir Pirmohamed
Transport of gabapentin by LAT1 (SLC7A5).
Biochemical pharmacology 2013;85(11):1672-83.
2013: Catherine C Bell; John Farrell; Lee Faulkner; Klara Martinsson; Dean J Naisbitt; Munir Pirmohamed; Jonathan D Tugwood; Ana Alfirevic; B Kevin Park
T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms.
Chemical research in toxicology 2013;26(5):759-66.
2013: V L M Yip; Munir Pirmohamed; Ana Alfirevic
Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".
Clinical pharmacology and therapeutics 2013;93(5):387.
2013: Daniel Carr; Elena Cornejo Castro; Mas Chaponda; Robert S Heyderman; Andrea L Jorgensen; Saye H Khoo; David Lalloo; Ana Alfirevic; Joep J G van Oosterhout; Munir Pirmohamed
Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013;56(9):1330-9.
2013: Jean G Sathish; Swaminathan Sethu; Jennifer Sims; Meena Subramanyam; Marque D Todd; Jan Willem Van Der Laan; Richard J Weaver; Munir Pirmohamed; Gabriele Reichmann; Marie-Christine Bielsky; Lolke de Haan; Neil S French; Karthik Govindappa; James Green; Christopher E M Griffiths; Stephen Holgate; David Jones; Ian Kimber; Jonathan Moggs; Dean J Naisbitt; B Kevin Park
Challenges and approaches for the development of safer immunomodulatory biologics.
Nature reviews. Drug discovery 2013;12(4):306-24.
2013: Janine Arnott; Hannah Hesselgreaves; Anthony J Nunn; Matthew Peak; Munir Pirmohamed; Rosalind L Smyth; Mark A Turner; Bridget Young
What can we learn from parents about enhancing participation in pharmacovigilance?
British journal of clinical pharmacology 2013;75(4):1109-17.
2013: Daniel B Hawcutt; Rosalind L Smyth; Ben Thompson; Munir Pirmohamed
Paediatric pharmacogenomics: an overview.
Archives of disease in childhood 2013;98(3):232-7.
2013: C O Musumba; N O'Hara; Daniel Carr; Andrea L Jorgensen; D Mark Pritchard; L Sutton; D Van Eker; E Zhang; Munir Pirmohamed
CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease.
Clinical pharmacology and therapeutics 2013;93(2):195-203.
2013: Manal M Monshi; B Kevin Park; Munir Pirmohamed; Ana Alfirevic; Karin Cederbrant; Ann K Daly; Caroline J Earnshaw; John Farrell; Lee Faulkner; Neil French; Andrew Gibson; Rosalind E Jenkins; Dean J Naisbitt
Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury.
Hepatology (Baltimore, Md.) 2013;57(2):727-39.
2013: Athina Giannoudis; Tessa L Holyoake; Andrea L Jorgensen; Panagiotis D Kottaridis; Triantafilos Liloglou; Martin C Müller; Munir Pirmohamed; Sudeep Pushpakom; Lihui Wang; George Xinarianos; Jieying-Eunice Zhang; Gemma Austin; Andrea Davies; Letizia Foroni; Richard E Clark
The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia.
Blood 2013;121(4):628-37.
2013: Munir Pirmohamed
Author's reply to Backman and Bakhai.
BMJ (Clinical research ed.) 2013;346():f1078.
2013: Andrea L Jorgensen; Munir Pirmohamed; Cheng Hock Toh; Diane van Eker; Anita Hanson; Dyfrig A Hughes; Paula R Williamson
Adherence and variability in warfarin dose requirements: assessment in a prospective cohort.
Pharmacogenomics 2013;14(2):151-63.
2013: Munir Pirmohamed
Drug-grapefruit juice interactions: two mechanisms are clear but individual responses vary.
BMJ (Clinical research ed.) 2013;346():f1.
2013: Munir Pirmohamed; Dyfrig A Hughes
Pharmacogenetic tests: the need for a level playing field.
Nature reviews. Drug discovery 2013;12(1):3-4.
2013: Heather J Downing; Munir Pirmohamed; Michael W Beresford; Rosalind L Smyth
Paediatric use of mycophenolate mofetil.
British journal of clinical pharmacology 2013;75(1):45-59.
2012: V L Yip; Andrea L Jorgensen; Anthony G Marson; Munir Pirmohamed; Ana Alfirevic
HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.
Clinical pharmacology and therapeutics 2012;92(6):757-65.
2012: Ana Alfirevic; B Kevin Park; Munir Pirmohamed; Dean J Naisbitt
Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity.
Pharmacogenomics 2012;13(14):1567-9.
2012: Swaminathan Sethu; Mohammad Alhaidari; Karthik Govindappa; Kevin Park; Munir Pirmohamed; Jean Sathish
Immunogenicity to biologics: mechanisms, prediction and reduction.
Archivum immunologiae et therapiae experimentalis 2012;60(5):331-44.
2012: Talitha I Verhoef; Mia Wadelius; Samira Bayat; Ann K Daly; Anthonius de Boer; Mary Geitona; Elisabeth Haschke-Becher; Dyfrig A Hughes; Farhad Kamali; Lars-Åke Levin; Anke Hilse Maitland-van der Zee; Vangelis G Manolopoulos; Munir Pirmohamed; William K Redekop; Uwe Siebert; Julia C Stingl; Rianne Mf van Schie
Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs.
Pharmacogenomics 2012;13(12):1405-17.
2012: Ana Alfirevic; Munir Pirmohamed
Predictive genetic testing for drug-induced liver injury: considerations of clinical utility.
Clinical pharmacology and therapeutics 2012;92(3):376-80.
2012: C Musumba; M Hopkins; A Jorgensen; J Moorcroft; D Mark Pritchard; L Sutton; D Van Eker; Munir Pirmohamed
The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010.
Alimentary pharmacology & therapeutics 2012;36(1):48-56.
2012: Sabah El-Ghaiesh; Ayman Elsheikh; John Farrell; Neil French; Rosalind Jenkins; Xiaoli Meng; Manal M Monshi; B Kevin Park; Daniel Peckham; Munir Pirmohamed; Paul Whitaker; Dean J Naisbitt
Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis.
The Journal of pharmacology and experimental therapeutics 2012;341(3):597-610.
2012: David Dickens; Athina Giannoudis; Andrew Owen; Ana Alfirevic; Pierre-Olivier Couraud; Andrea Davies; Ignacio A Romero; Babette Weksler; Munir Pirmohamed
Lamotrigine is a substrate for OCT1 in brain endothelial cells.
Biochemical pharmacology 2012;83(6):805-14.
2012: Daniel B Hawcutt; Pramod Mainie; Andrew Riordan; Rosalind L Smyth; Munir Pirmohamed
Reported paediatric adverse drug reactions in the UK 2000-2009.
British journal of clinical pharmacology 2012;73(3):437-46.
2012: S L Forchap; Munir Pirmohamed; Richard E Clark
Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis.
Leukemia 2012;26(3):490-8.
2012: Daniel J Cuthbertson; Christina Daousi; Niall Furlong; Chris J Gardner; Niru Goenka; Andrew Irwin; Munir Pirmohamed; Tej Purewal; Sudeep P Pushpakom; E Louise Thomas; Valerie L Adams; Graham J Kemp
Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists.
PloS one 2012;7(12):e50117.
2012: Ruairi M Gallagher; Jamie J Kirkham; Jennifer R Mason; Anthony J Nunn; Matthew Peak; Munir Pirmohamed; Mark A Turner; Paula R Williamson; Kim A Bird; Rosalind L Smyth
Adverse drug reactions causing admission to a paediatric hospital.
PloS one 2012;7(12):e50127.
2012: Janine Arnott; Hannah Hesselgreaves; Anthony J Nunn; Matthew Peak; Munir Pirmohamed; Rosalind L Smyth; Mark A Turner; Bridget Young
Enhancing communication about paediatric medicines: lessons from a qualitative study of parents' experiences of their child's suspected adverse drug reaction.
PloS one 2012;7(10):e46022.
2012: Andrea L Jorgensen; James Oyee; Munir Pirmohamed; Richard J FitzGerald; Paula R Williamson
Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis.
PloS one 2012;7(8):e44064.
2012: Stephen J McWilliam; B Kevin Park; Daniel J Antoine; Joseph V Bonventre; Tracey Farragher; Venkata Sabbisetti; Rosalind L Smyth; Mark A Turner; Munir Pirmohamed
Mechanism-based urinary biomarkers to identify the potential for aminoglycoside-induced nephrotoxicity in premature neonates: a proof-of-concept study.
PloS one 2012;7(8):e43809.
2012: Ana Alfirevic; Catherine Bell; Giovanna Bretland; Karin Cederbrant; Jane Evely; Neil French; Faviel Gonzalez-Galarza; Andrew R Jones; Maike Lichtenfels; Klara Martinsson; Dean J Naisbitt; B Kevin Park; Vivien Platt; Munir Pirmohamed
In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers.
Genome medicine 2012;4(6):51.
2012: Munir Pirmohamed
Genetics and the potential for predictive tests in adverse drug reactions.
Chemical immunology and allergy 2012;97():18-31.
2012: Tjeerd-Pieter van Staa; Adel Taweel; Jackie Anne Cassell; Brendan Delaney; Ben Goldacre; Martin Gulliford; Munir Pirmohamed; Liam Smeeth
Pragmatic randomised trials using routine electronic health records: putting them to the test.
BMJ (Clinical research ed.) 2012;344():e55.
2012: Neill J Liptrott; Stefan Mauss; Andrew Owen; Munir Pirmohamed; Sudeep Pushpakom; Marco Siccardi; Christoph Wyen; David J Back; Norbert H Brockmeyer; Gerd Fätkenheuer; Christian Hoffmann; Elizabeth Hopper-Borge; Saye H Khoo; Heribert Knechten
Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS.
Pharmacogenetics and genomics 2012;22(1):10-9.
2012: Steven Lane; Ivan Matthews; Kayode Ogungbenro; B Kevin Park; Leon Aarons; Sameh Al-Zubiedi; Ann K Daly; Panos Deloukas; Ellen Hatch; Dyfrig Hughes; Andrea L Jorgensen; Farhad Kamali; Munir Pirmohamed
The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.
British journal of clinical pharmacology 2012;73(1):66-76.
2011: Nasir Mirza; Anthony Guy Marson; Olga Vasieva; Munir Pirmohamed
Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery.
Human molecular genetics 2011;20(22):4381-94.
2011: Munir Pirmohamed
Pharmacogenetics: past, present and future.
Drug discovery today 2011;16(19-20):852-61.
2011: Xiaoli Meng; Dean J Naisbitt; Munir Pirmohamed; Andrew V Stachulski; Neil G Berry; John Farrell; Neil S French; Rosalind E Jenkins; Catherine S Lane; James L Maggs; B Kevin Park
Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients.
The Journal of pharmacology and experimental therapeutics 2011;338(3):841-9.
2011: Sabah El-Ghaiesh; John Farrell; Sidonie N Lavergne; B Kevin Park; Munir Pirmohamed; Joseph Sanderson; Wing-Kin Syn; Dean J Naisbitt
Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.
The Journal of allergy and clinical immunology 2011;128(3):680-3.
2011: Catriona John Waitt; Sarah A White; Robert S Heyderman; Beate Kampmann; Johnstone J Kumwenda; N Peter K Banda; Munir Pirmohamed; S Bertel Squire
Early deaths during tuberculosis treatment are associated with depressed innate responses, bacterial infection, and tuberculosis progression.
The Journal of infectious diseases 2011;204(3):358-62.
2011: Sudeep P Pushpakom; Neill J Liptrott; Sonia Rodríguez-Nóvoa; Pablo Labarga; Vincent Soriano; Marta Albalater; Elizabeth Hopper-Borge; Stefano Bonora; Giovanni Di Perri; David J Back; Saye Khoo; Munir Pirmohamed; Andrew Owen
Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction.
The Journal of infectious diseases 2011;204(1):145-53.
2011: Paul Whitaker; Daniel G Peckham; Munir Pirmohamed; Steve Conway; Caroline Earnshaw; Sabah El-Ghaiesh; Jimmy Gooi; Rosalind E Jenkins; Sidonie N Lavergne; Xiaoli Meng; Manal Monshi; Dean J Naisbitt; B Kevin Park
Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):200-11.
2011: Kathryn Cobain; Richard Fitzgerald; Ian Gilmore; Ruwanthi Kolamunnage-Dona; Lynn Owens; Munir Pirmohamed
Brief interventions in dependent drinkers: a comparative prospective analysis in two hospitals.
Alcohol and alcoholism (Oxford, Oxfordshire) 2011;46(4):434-40.
2011: Sabah El-Ghaiesh; John Farrell; Sidonie N Lavergne; B Kevin Park; Munir Pirmohamed; Joseph Sanderson; Wing-Kin Syn; Dean J Naisbitt
Trimethoprim stimulates T-cells through metabolism-dependent and -independent pathways.
Chemical research in toxicology 2011;24(6):791-3.
2011: Munir Pirmohamed; G P Aithal; E Behr; A Daly; D Roden
The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions.
Clinical pharmacology and therapeutics 2011;89(6):784-5.
2011: Munir Pirmohamed; Peter S Friedmann; M Molokhia; Y K Loke; C Smith; E Phillips; L La Grenade; B Carleton; M Papaluca-Amati; P Demoly; N H Shear
Phenotype standardization for immune-mediated drug-induced skin injury.
Clinical pharmacology and therapeutics 2011;89(6):896-901.
2011: Meike Vogler; David Dickens; Martin J S Dyer; Andrew Owen; Munir Pirmohamed; Gerald M Cohen
The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.
Biochemical and biophysical research communications 2011;408(2):344-9.
2011: Mas Chaponda; Munir Pirmohamed
Hypersensitivity reactions to HIV therapy.
British journal of clinical pharmacology 2011;71(5):659-71.
2011: Richard Fitzgerald; Munir Pirmohamed
Aspirin resistance: effect of clinical, biochemical and genetic factors.
Pharmacology & therapeutics 2011;130(2):213-25.
2011: Nasir S Mirza; Ana Alfirevic; Andrea Jorgensen; Anthony G Marson; Munir Pirmohamed
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.
Pharmacogenetics and genomics 2011;21(5):297-302.
2011: Mark McCormack; Ana Alfirevic; Stephane Bourgeois; John J Farrell; Dalia Kasperavičiūtė; Mary Carrington; Graeme J Sills; Tony Marson; Xiaoming Jia; Paul I W de Bakker; Krishna Chinthapalli; Mariam Molokhia; Michael R Johnson; Gerard D O'Connor; Elijah Chaila; Saud Alhusaini; Kevin V Shianna; Rodney A Radtke; Erin L Heinzen; Nicole Walley; Massimo Pandolfo; Werner Pichler; B Kevin Park; Chantal Depondt; Sanjay M Sisodiya; David B Goldstein; Panos Deloukas; Norman Delanty; Gianpiero L Cavalleri; Munir Pirmohamed
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
The New England journal of medicine 2011;364(12):1134-43.
2011: Andrea L Jorgensen; Munir Pirmohamed
Risk modeling strategies for pharmacogenetic studies.
Pharmacogenomics 2011;12(3):397-410.
2011: Sudeep P Pushpakom; Andrew Owen; F Javier Vilar; Hannah Castro; David T Dunn; David J Back; Munir Pirmohamed
Adipogenic gene variants in patients with HIV-associated lipodystrophy.
Pharmacogenetics and genomics 2011;21(2):76-83.
2011: Nigel Fleeman; Yenal Dundar; Rumona Dickson; Andrea L Jorgensen; S Pushpakom; C McLeod; Munir Pirmohamed; Tom Walley
Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses.
The pharmacogenomics journal 2011;11(1):1-14.
2011: Joshua Pink; Munir Pirmohamed; Steven Lane; Dyfrig A Hughes
Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses.
BMJ (Clinical research ed.) 2011;343():d6333.
2011: Fabio Miyajima; Christopher Parry; Neil Pendleton; Nicholas Beeching; Jonathan Brazier; Michael Horan; Maureen Jones; Valerie Price; Paul Roberts; Andrew Swale; Munir Pirmohamed
Characterisation and carriage ratio of Clostridium difficile strains isolated from a community-dwelling elderly population in the United Kingdom.
PloS one 2011;6(8):e22804.
2011: Lynn Owens; James Oyee; Liz Perkins; Graham Butcher; Ian Gilmore; Ruwanthi Kolamunnage-Dona; Tom Walley; Paula Williamson; Ken Wilson; Munir Pirmohamed
A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC).
BMC public health 2011;11():528.
2011: Thomas Eschenhagen; Thomas Force; Michael S Ewer; Gilles W De Keulenaer; Thomas M Suter; Stefan D Anker; Metin Avkiran; Evandro de Azambuja; Jean-Luc Balligand; Dirk L Brutsaert; Gianluigi Condorelli; Arne Hansen; Stephane Heymans; Joseph A Hill; Emilio Hirsch; Denise Hilfiker-Kleiner; Stefan Janssens; Steven de Jong; Gitte Neubauer; Burkert Pieske; Piotr Ponikowski; Munir Pirmohamed; Mathias Rauchhaus; Douglas Sawyer; Peter H Sugden; Johann Wojta; Faiez Zannad; Ajay M Shah
Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology.
European journal of heart failure 2011;13(1):1-10.
2010: Munir Pirmohamed
Acceptance of biomarker-based tests for application in clinical practice: criteria and obstacles.
Clinical pharmacology and therapeutics 2010;88(6):862-6.
2010: Peter T Donaldson; Ann K Daly; Jill Henderson; Julia Graham; Munir Pirmohamed; William Bernal; Christopher P Day; Guruprasad P Aithal
Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury.
Journal of hepatology 2010;53(6):1049-53.
2010: Emma C Davies; CF Green; David R Mottram; Philip H Rowe; Munir Pirmohamed
Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission.
British journal of clinical pharmacology 2010;70(5):749-55.
2010: Daniel Carr; Charles J L la Porte; Munir Pirmohamed; Andrew Owen; Claudia P Cortes
Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort.
The Journal of antimicrobial chemotherapy 2010;65(9):1889-93.
2010: Emma C Davies; CF Green; David R Mottram; Munir Pirmohamed
Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents.
British journal of clinical pharmacology 2010;70(1):102-8.
2010: Talitha I Verhoef; William K Redekop; Josep Darba; Mary Geitona; Dyfrig A Hughes; Uwe Siebert; Anthonius de Boer; Anke Hilse Maitland-van der Zee; Rita Barallon; Montserrat Briz; Ann Daly; Elisabeth Haschke-Becher; Farhad Kamali; Julia Kirchheiner; Vangelis G Manolopoulos; Munir Pirmohamed; Frits R Rosendaal; Rianne M F van Schie; Mia Wadelius
A systematic review of cost-effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives.
Pharmacogenomics 2010;11(7):989-1002.
2010: Nita A Limdi; Mia Wadelius; Larisa H Cavallari; Niclas Eriksson; Dana C Crawford; Ming-Ta M Lee; Chien-Hsiun Chen; Alison Motsinger-Reif; Hersh Sagreiya; Nianjun Liu; Alan H B Wu; Brian F Gage; Andrea Jorgensen; Munir Pirmohamed; Jae-Gook Shin; Guilherme Suarez-Kurtz; Stephen E Kimmel; Julie A Johnson; Teri E Klein; Michael J Wagner
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups.
Blood 2010;115(18):3827-34.
2010: Elise Andrews; Martin Armstrong; Jonathan Tugwood; Dan Swan; Philip Glaves; Munir Pirmohamed; Guruprasad P Aithal; Matthew C Wright; Christopher P Day; Ann K Daly
A role for the pregnane X receptor in flucloxacillin-induced liver injury.
Hepatology (Baltimore, Md.) 2010;51(5):1656-64.
2010: Ana Alfirevic; Munir Pirmohamed
Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.
Pharmacogenomics 2010;11(4):497-9.
2010: David Gurwitz; Munir Pirmohamed
Pharmacogenomics: the importance of accurate phenotypes.
Pharmacogenomics 2010;11(4):469-70.
2010: Claire Jenkinson; Rosalind E Jenkins; Maja Aleksic; Munir Pirmohamed; Dean J Naisbitt; B Kevin Park
Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein.
The Journal of investigative dermatology 2010;130(3):732-42.
2010: Daniel J Antoine; Abhishek Srivastava; Munir Pirmohamed; B Kevin Park
Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells.
Biochemical pharmacology 2010;79(4):647-54.
2010: Munir Pirmohamed
Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff.
Wiener klinische Wochenschrift 2010;122(3-4):62-4.
2010: Alieu AMARA; Asheesh Sharma; John L Alexander; Ana Alfirevic; Atif Mohiuddin; Munir Pirmohamed; Graeme L Close; Steve Grime; Paul Maltby; Howida Shawki; Sally Heyworth; Alan Shenkin; Linda Smith; Ajay K Sharma; Abdel Hammad; Rana Rustom
Randomized controlled trial: lisinopril reduces proteinuria, ammonia, and renal polypeptide tubular catabolism in patients with chronic allograft nephropathy.
Transplantation 2010;89(1):104-14.
2010: Nigel Fleeman; C McLeod; Adrian Bagust; Sophie Beale; Angela Boland; Yenal Dundar; Andrea L Jorgensen; K Payne; Munir Pirmohamed; S Pushpakom; Tom Walley; P de Warren-Penny; Rumona Dickson
The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation.
Health technology assessment (Winchester, England) 2010;14(3):1-157, iii.
2010: Munir Pirmohamed
Pharmacogenetics of idiosyncratic adverse drug reactions.
Handbook of experimental pharmacology 2010;(196):477-91.
2010: Ana Alfirevic; Zarko Alfirevic; Munir Pirmohamed
Pharmacogenetics in reproductive and perinatal medicine.
Pharmacogenomics 2010;11(1):65-79.
2010: Omar Janneh; Andrew Owen; Patrick G Bray; David J Back; Munir Pirmohamed
The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes.
British journal of pharmacology 2010;159(2):484-93.
2010: Abhishek Srivastava; Lu-Yun Lian; James L Maggs; Masautso Chaponda; Munir Pirmohamed; Dominic P Williams; B Kevin Park
Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(1):122-32.
2010: Eve M Coulter; Claire Jenkinson; John Farrell; Sidonie N Lavergne; Camilla K Pease; Andrew White; Maja Aleksic; David Basketter; Dominic P Williams; Clodagh King; Munir Pirmohamed; B Kevin Park; Dean J Naisbitt
Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals.
The Journal of investigative dermatology 2010;130(1):161-74.
2009: Nasir Mirza; Anthony G Marson; Munir Pirmohamed
Effect of topiramate on acid-base balance: extent, mechanism and effects.
British journal of clinical pharmacology 2009;68(5):655-61.
2009: A Davies; N E Jordanides; A Giannoudis; C M Lucas; S Hatziieremia; Robert J Harris; Heather G Jørgensen; T L Holyoake; Munir Pirmohamed; Richard E Clark; J C Mountford
Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.
Leukemia 2009;23(11):1999-2006.
2009: Munir Pirmohamed
The applications of pharmacogenetics to prescribing: what is currently practicable?
Clinical medicine (London, England) 2009;9(5):493-5.
2009: Rianne M F van Schie; M I A Wadelius; Farhad Kamali; Ann K Daly; Vangelis G Manolopoulos; Anthonius de Boer; Rita Barallon; Talitha I Verhoef; Julia Kirchheiner; Elisabeth Haschke-Becher; Montserrat Briz; Frits R Rosendaal; William K Redekop; Munir Pirmohamed; Anke-Hilse Maitland van der Zee
Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design.
Pharmacogenomics 2009;10(10):1687-95.
2009: Andrea L Jorgensen; Sameh Al-Zubiedi; Jieying Eunice Zhang; Andrew Keniry; Anita Hanson; Dyfrig A Hughes; Lisa Stevens; Karen Hawkins; Cheng H Toh; Farhad Kamali; Ann K Daly; David Fitzmaurice; Alison Coffey; Paula R Williamson; Brian Kevin Park; Panos Deloukas; Diane van Eker; Munir Pirmohamed
Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.
Pharmacogenetics and genomics 2009;19(10):800-12.
2009: Jieying Eunice Zhang; Andrea L Jorgensen; Ana Alfirevic; Paula R Williamson; Cheng H Toh; Brian Kevin Park; Munir Pirmohamed
Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy.
Pharmacogenetics and genomics 2009;19(10):781-9.
2009: Daniel Carr; G Whiteley; Ana Alfirevic; Munir Pirmohamed
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.
The pharmacogenomics journal 2009;9(5):291-305.
2009: C Musumba; D Mark Pritchard; Munir Pirmohamed
Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers.
Alimentary pharmacology & therapeutics 2009;30(6):517-31.
2009: Ramatoulie E Janha; Fatoumatta Sisay-Joof; Majidah Hamid-Adiamoh; Archibald Worwui; Hannah L Chapman; Hyginus Opara; Sam Dunyo; Paul Milligan; Kirk Rockett; Peter Winstanley; Munir Pirmohamed; Ann K Miller; David J Conway; Robert T Walton
Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.
Pharmacogenomics 2009;10(9):1423-31.
2009: Amitava Ganguli; Lauren Walker; Richard Joaquim FitzGerald; Munir Pirmohamed
Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.
The Annals of pharmacotherapy 2009;43(9):1528-31.
2009: Munir Pirmohamed
Clinical management of HIV-associated lipodystrophy.
Current opinion in lipidology 2009;20(4):309-14.
2009: Ann K Daly; Peter T Donaldson; Pallav Bhatnagar; Yufeng Shen; Itsik Pe'er; Aris Floratos; Mark J Daly; David B Goldstein; Sally John; Matthew R Nelson; Julia Graham; B Kevin Park; John F Dillon; William Bernal; Heather J Cordell; Munir Pirmohamed; Guruprasad P Aithal; Christopher P Day
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
Nature genetics 2009;41(7):816-9.
2009: Rosalind E Jenkins; Xiaoli Meng; Victoria Louise Elliott; Neil R Kitteringham; Munir Pirmohamed; B Kevin Park
Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo.
Proteomics. Clinical applications 2009;3(6):720-9.
2009: Philip Sasi; Abdi Abdulrahaman; Leah Mwai; Steven Muriithi; Judith Straimer; Elise Schieck; Anja Rippert; Mahfudh Bashraheil; Amina Salim; Judith Peshu; Ken Awuondo; Brett Lowe; Munir Pirmohamed; Peter Winstanley; Steve Ward; Alexis Nzila; Steffen Borrmann
In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa.
The Journal of infectious diseases 2009;199(11):1575-82.
2009: Ana Alfirevic; F Javier Vilar; Mohammed Alsbou; Ansar Jawaid; Wendy Thomson; William E R Ollier; Clive E Bowman; Olivier Delrieu; B Kevin Park; Munir Pirmohamed
TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.
Pharmacogenomics 2009;10(4):531-40.
2009: Emma C Davies; CF Green; Stephen Taylor; Paula R Williamson; David R Mottram; Munir Pirmohamed
Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes.
PloS one 2009;4(2):e4439.
2008: Athina Giannoudis; Andrea Davies; Claire M Lucas; Robert J Harris; Munir Pirmohamed; Richard E Clark
Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia.
Blood 2008;112(8):3348-54.
2008: Jane E Mallewa; Edmund Wilkins; Javier Vilar; Macpherson Mallewa; Dominic Doran; David Back; Munir Pirmohamed
HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options.
The Journal of antimicrobial chemotherapy 2008;62(4):648-60.
2008: Simon P Jones; Catriona Waitt; Robert Sutton; David J Back; Munir Pirmohamed
Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes.
AIDS (London, England) 2008;22(11):1293-8.
2008: Richard E Clark; Andrea Davies; Munir Pirmohamed; A Giannoudis
Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia.
Leukemia & lymphoma 2008;49(4):639-42.
2008: Eve Marie Coulter; Claire Jenkinson; Ying Wu; John Farrell; Brian Foster; Andrew Smith; Carolann McGuire; Camilla K Pease; David A Basketter; Clodagh King; Peter S Friedmann; Munir Pirmohamed; Brian Kevin Park; Dean J Naisbitt
Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base.
The Journal of investigative dermatology 2008;128(4):897-905.
2007: Guy Leschziner; Andrea L Jorgensen; Toby Andrew; Paula R Williamson; Anthony G Marson; Alison J Coffey; Claire Middleditch; David J Balding; Jane Rogers; David R Bentley; David W Chadwick; Michael R Johnson; Munir Pirmohamed
The association between polymorphisms in RLIP76 and drug response in epilepsy.
Pharmacogenomics 2007;8(12):1715-22.
2007: Munir Pirmohamed; Julian B Arbuckle; Clive E Bowman; Margaret Brunner; Daniel K Burns; Olivier Delrieu; Lynn P Dix; John A Twomey; Robert S Stern
Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.
Pharmacogenomics 2007;8(12):1661-91.
2007: Ana Alfirevic; Tracy Mills; Daniel Carr; Bryan J Barratt; Ansar Jawaid; James Sherwood; John C Smith; Jonathan D Tugwood; Ruben C Hartkoorn; Andrew Owen; Kevin B Park; Munir Pirmohamed
Tacrine-induced liver damage: an analysis of 19 candidate genes.
Pharmacogenetics and genomics 2007;17(12):1091-100.
2007: Daniel Carr; Ana Alfirevic; Jonathan D Tugwood; Bryan J Barratt; James Sherwood; John Smith; Munir Pirmohamed; B Kevin Park
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity.
Pharmacogenetics and genomics 2007;17(11):961-72.
2007: Munir Pirmohamed; Kwame N Atuah; Alex N O Dodoo; Peter Winstanley
Pharmacovigilance in developing countries.
BMJ (Clinical research ed.) 2007;335(7618):462.
2007: Dyfrig A Hughes; A M Bayoumi; Munir Pirmohamed
Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?
Clinical pharmacology and therapeutics 2007;82(2):123-7.
2007: Guy Leschziner; Toby Andrew; Munir Pirmohamed; Michael R Johnson
ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.
The pharmacogenomics journal 2007;7(3):154-79.
2007: Munir Pirmohamed; Nicola S Drummond; Dean J Naisbitt; B Kevin Park
Drug hypersensitivity reactions in patients with HIV disease.
Expert review of clinical immunology 2007;3(3):395-410.
2007: Joseph Sanderson; Dean J Naisbitt; John Farrell; Charlotte A Ashby; M Jane Tucker; Michael J Rieder; Munir Pirmohamed; Stephen E Clarke; B Kevin Park
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5533-42.
2007: Ying Wu; John Farrell; Munir Pirmohamed; B Kevin Park; Dean J Naisbitt
Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.
The Journal of allergy and clinical immunology 2007;119(4):973-81.
2007: Guy Leschziner; Toby Andrew; John Paul Leach; David W Chadwick; Alison J Coffey; David J Balding; David R Bentley; Munir Pirmohamed; Michael R Johnson
Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach.
Pharmacogenetics and genomics 2007;17(3):217-20.
2007: Dean J Naisbitt; Munir Pirmohamed; B Kevin Park
Immunological principles of T-cell-mediated adverse drug reactions in skin.
Expert opinion on drug safety 2007;6(2):109-24.
2007: Simon Constable; Andrew Ham; Munir Pirmohamed
Herbal medicines and acute medical emergency admissions to hospital.
British journal of clinical pharmacology 2007;63(2):247-8.
2007: Emma C Davies; Christophe F Green; David R Mottram; Munir Pirmohamed
Adverse drug reactions in hospitals: a narrative review.
Current drug safety 2007;2(1):79-87.
2007: Seren Roberts; Emma Bedson; Dyfrig Hughes; Keith Lloyd; David B Menkes; Stuart Moat; Munir Pirmohamed; Gary Slegg; Johannes Thome; Richard Tranter; Rhiannon Whitaker; Clare Wilkinson; Ian T Russell
Folate augmentation of treatment - evaluation for depression (FolATED): protocol of a randomised controlled trial.
BMC psychiatry 2007;7():65.
2007: Dyfrig A Hughes; Munir Pirmohamed
Warfarin pharmacogenetics: economic considerations.
PharmacoEconomics 2007;25(11):899-902.
2006: Munir Pirmohamed
Warfarin: almost 60 years old and still causing problems.
British journal of clinical pharmacology 2006;62(5):509-11.
2006: Andrew Owen; Munir Pirmohamed; Saye H Khoo; David J Back
Pharmacogenetics of HIV therapy.
Pharmacogenetics and genomics 2006;16(10):693-703.
2006: Ana Alfirevic; Andrea L Jorgensen; Paula R Williamson; David W Chadwick; B Kevin Park; Munir Pirmohamed
HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.
Pharmacogenomics 2006;7(6):813-8.
2006: Guy Leschziner; Andrea L Jorgensen; Toby Andrew; Munir Pirmohamed; Paula R Williamson; Anthony G Marson; Alison J Coffey; Claire Middleditch; Jane Rogers; David R Bentley; David W Chadwick; David J Balding; Michael R Johnson
Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study.
Lancet neurology 2006;5(8):668-76.
2006: Andrew Owen; Chris Goldring; Paul Morgan; B Kevin Park; Munir Pirmohamed
Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements.
British journal of clinical pharmacology 2006;62(2):237-42.
2006: Ying Wu; Joseph Sanderson; John Farrell; Nicola S Drummond; Anita Hanson; Elizabeth Bowkett; Neil Berry; Andrew V Stachulski; Stephen E Clarke; Werner J Pichler; Munir Pirmohamed; B Kevin Park; Dean J Naisbitt
Activation of T cells by carbamazepine and carbamazepine metabolites.
The Journal of allergy and clinical immunology 2006;118(1):233-41.
2006: Farhad Kamali; Munir Pirmohamed
The future prospects of pharmacogenetics in oral anticoagulation therapy.
British journal of clinical pharmacology 2006;61(6):746-51.
2006: Guy Leschziner; Delilah Zabaneh; Munir Pirmohamed; Andrew Owen; Jane Rogers; Alison J Coffey; David J Balding; David B Bentley; Michael R Johnson
Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance.
Pharmacogenetics and genomics 2006;16(6):439-50.
2006: Ana Alfirevic; Tracy Mills; Pauline Harrington; Tracy Pinel; James Sherwood; Ansar Jawaid; John C Smith; Ruth E March; Bryan J Barratt; David W Chadwick; B Kevin Park; Munir Pirmohamed
Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster.
Pharmacogenetics and genomics 2006;16(4):287-96.
2006: Jeantine E Lunshof; Munir Pirmohamed; David Gurwitz
Personalized medicine: decades away?
Pharmacogenomics 2006;7(2):237-41.
2006: Simon Constable; Michael R Johnson; Munir Pirmohamed
Pharmacogenetics in clinical practice: considerations for testing.
Expert review of molecular diagnostics 2006;6(2):193-205.
2006: Rebecca S Gruchalla; Munir Pirmohamed
Clinical practice. Antibiotic allergy.
The New England journal of medicine 2006;354(6):601-9.
2006: Nicola S Drummond; F Javier Vilar; Dean J Naisbitt; Anita Hanson; Anthony Woods; B Kevin Park; Munir Pirmohamed
Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis.
Antiviral therapy 2006;11(3):393-5.
2006: Munir Pirmohamed
Genetic factors in the predisposition to drug-induced hypersensitivity reactions.
The AAPS journal 2006;8(1):E20-6.
2006: Trudie Lang; Dyfrig Hughes; Tom Kanyok; Jane F Kengeya-Kayondo; Vicki Marsh; Ane Haaland; Munir Pirmohamed; Peter A Winstanley
Beyond registration--measuring the public-health potential of new treatments for malaria in Africa.
The Lancet infectious diseases 2006;6(1):46-52.
2005: Simon P Jones; Nadeem Qazi; John Morelese; Dirk Lebrecht; Jussi Sutinen; Hannele Yki-Jărvinen; David J Back; Munir Pirmohamed; Brian G Gazzard; Ulrich A Walker; Graeme J Moyle
Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens.
Journal of acquired immune deficiency syndromes (1999) 2005;40(5):565-72.
2005: Robin E Ferner; Jamie Coleman; Munir Pirmohamed; Simon A Constable; Andrew Rouse
The quality of information on monitoring for haematological adverse drug reactions.
British journal of clinical pharmacology 2005;60(4):448-51.
2005: Lynn Owens; Ian T Gilmore; Munir Pirmohamed
How do NHS general hospitals in England deal with patients with alcohol-related problems? A questionnaire survey.
Alcohol and alcoholism (Oxford, Oxfordshire) 2005;40(5):409-12.
2005: Kevin Park; Dominic P Williams; Dean J Naisbitt; Neil R Kitteringham; Munir Pirmohamed
Investigation of toxic metabolites during drug development.
Toxicology and applied pharmacology 2005;207(2 Suppl):425-34.
2005: Lucy C Crossman; Brian J Druker; Michael W N Deininger; Munir Pirmohamed; Lihui Wang; Richard E Clark
hOCT 1 and resistance to imatinib.
Blood 2005;106(3):1133-4; author reply 1134.
2005: Dean J Naisbitt; John Farrell; Peter J Chamberlain; Josephine E Hopkins; Neil G Berry; Munir Pirmohamed; B Kevin Park
Characterization of the T-cell response in a patient with phenindione hypersensitivity.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1058-65.
2005: Dean John Naisbitt; Munir Pirmohamed; Brian Kevin Park
Drug presentation to T cells.
The Journal of allergy and clinical immunology 2005;115(4):876-7; author reply 877-8.
2005: Andrew Owen; Chris Goldring; Paul Morgan; David W Chadwick; B Kevin Park; Munir Pirmohamed
Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver.
British journal of clinical pharmacology 2005;59(3):365-70.
2005: Simon P Jones; Omar Janneh; David J Back; Munir Pirmohamed
Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors.
Antiviral therapy 2005;10(2):207-13.
2005: B Kevin Park; Neil R Kitteringham; James L Maggs; Munir Pirmohamed; Dominic P Williams
The role of metabolic activation in drug-induced hepatotoxicity.
Annual review of pharmacology and toxicology 2005;45():177-202.
2005: Munir Pirmohamed
Anticipating, investigating and managing the adverse effects of drugs.
Clinical medicine (London, England) 2005;5(1):23-6.
2004: Bridget Maher; Judy Lloyd; Edmund G L Wilkins; William D Fraser; David Back; B Kevin Park; Munir Pirmohamed
Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-alpha and TNF-receptor levels, and on metabolic parameters.
Antiviral therapy 2004;9(6):879-87.
2004: Julia Thomas; Lihui Wang; Richard E Clark; Munir Pirmohamed
Active transport of imatinib into and out of cells: implications for drug resistance.
Blood 2004;104(12):3739-45.
2004: Alison Brind; A Hurlstone; D Edrisinghe; I Gilmore; Neil Fisher; Munir Pirmohamed; Anthony A Fryer
The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease.
Alcohol and alcoholism (Oxford, Oxfordshire) 2004;39(6):478-83.
2004: Ricky A Sharma; Stephanie A Euden; Sharon L Platton; Darren N Cooke; Aisha Shafayat; Heather R Hewitt; Timothy H Marczylo; Bruno Morgan; David Hemingway; Simon M Plummer; Munir Pirmohamed; Andreas J Gescher; William P Steward
Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):6847-54.
2004: Carrie Greenough; Rosalind E Jenkins; Neil R Kitteringham; Munir Pirmohamed; B Kevin Park; Stephen R Pennington
A method for the rapid depletion of albumin and immunoglobulin from human plasma.
Proteomics 2004;4(10):3107-11.
2004: Munir Pirmohamed; Sally James; Shaun Meakin; Chris Green; Andrew K Scott; Thomas J Walley; Keith Farrar; B Kevin Park; Alasdair M Breckenridge
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients.
BMJ (Clinical research ed.) 2004;329(7456):15-9.
2004: Munir Pirmohamed; Janet Darbyshire
Collecting and sharing information about harms.
BMJ (Clinical research ed.) 2004;329(7456):6-7.
2004: Dyfrig A Hughes; F Javier Vilar; Charlotte C Ward; Ana Alfirevic; B Kevin Park; Munir Pirmohamed
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.
Pharmacogenetics 2004;14(6):335-42.
2004: Simon Constable; Munir Pirmohamed
Drugs and the retina.
Expert opinion on drug safety 2004;3(3):249-59.
2004: Dave Singh; John Alexander; Andrew Owen; Rana Rustom; Mike Bone; Abdel Hammad; Norman Roberts; Kevin Park; Munir Pirmohamed
Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression.
Transplantation 2004;77(4):557-61.
2004: Kwame N Atuah; Dyfrig Hughes; Munir Pirmohamed
Clinical pharmacology: special safety considerations in drug development and pharmacovigilance.
Drug safety : an international journal of medical toxicology and drug experience 2004;27(8):535-54.
2003: Rafe Suvarna; Munir Pirmohamed; Leigh Henderson
Possible interaction between warfarin and cranberry juice.
BMJ (Clinical research ed.) 2003;327(7429):1454.
2003: Munir Pirmohamed; Robin E Ferner
Monitoring drug treatment.
BMJ (Clinical research ed.) 2003;327(7425):1179-81.
2003: Greg Bisson; Robert Gross; Veronica Miller; Ian Weller; Alexander Walker; Peter Arlett; Andrew Carr; Stephen Evans; David Graham; Amy Justice; Carmen Kreft-Jais; Jens D Lundgren; Bob Munk; Jeff Murray; Munir Pirmohamed; David Pizzuti; Ana Szarfman
Monitoring of long-term toxicities of HIV treatments: an international perspective.
AIDS (London, England) 2003;17(17):2407-17.
2003: Omar Janneh; Patrick G Hoggard; John F Tjia; Simon P Jones; Saye H Khoo; Bridget Maher; David J Back; Munir Pirmohamed
Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes.
Antiviral therapy 2003;8(5):417-26.
2003: Dominic P Williams; Charles J L O'Donnell; James L Maggs; J Steven Leeder; Jack P Uetrecht; Munir Pirmohamed; B Kevin Park
Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.
Chemical research in toxicology 2003;16(10):1359-64.
2003: Munir Pirmohamed; B Kevin Park
Cytochrome P450 enzyme polymorphisms and adverse drug reactions.
Toxicology 2003;192(1):23-32.
2003: John Farrell; Dean J Naisbitt; Nicola S Drummond; Jan P H Depta; F Javier Vilar; Munir Pirmohamed; B Kevin Park
Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans.
The Journal of pharmacology and experimental therapeutics 2003;306(1):229-37.
2003: Alison Brind; Anthony A Fryer; A Hurlstone; Neil Fisher; Munir Pirmohamed
The role of polymorphism in manganese superoxide dismutase in susceptibility to alcoholic liver disease.
Gastroenterology 2003;124(7):2000-2.
2003: Dean J Naisbitt; John Farrell; Gavin Wong; Jan P H Depta; Charlotte C Dodd; Josephine E Hopkins; Claire A Gibney; David W Chadwick; Werner J Pichler; Munir Pirmohamed; B Kevin Park
Characterization of drug-specific T cells in lamotrigine hypersensitivity.
The Journal of allergy and clinical immunology 2003;111(6):1393-403.
2003: F Javier Vilar; Dean J Naisbitt; B Kevin Park; Munir Pirmohamed
Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.
Journal of HIV therapy 2003;8(2):42-7.
2003: Munir Pirmohamed; B Kevin Park
Adverse drug reactions: back to the future.
British journal of clinical pharmacology 2003;55(5):486-92.
2003: Sally Morrison-Griffiths; Thomas J Walley; B Kevin Park; Alasdair M Breckenridge; Munir Pirmohamed
Reporting of adverse drug reactions by nurses.
Lancet 2003;361(9366):1347-8.
2003: Dean J Naisbitt; Markus Britschgi; G Wong; John Farrell; Jan P H Depta; David W Chadwick; Werner J Pichler; Munir Pirmohamed; B Kevin Park
Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.
Molecular pharmacology 2003;63(3):732-41.
2003: Ana Alfirevic; Anne C Stalford; F Javier Vilar; Ed G L Wilkins; B Kevin Park; Munir Pirmohamed
Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity.
British journal of clinical pharmacology 2003;55(2):158-65.
2003: Dean J Naisbitt; Munir Pirmohamed; B Kevin Park
Immunopharmacology of hypersensitivity reactions to drugs.
Current allergy and asthma reports 2003;3(1):22-9.
2002: Munir Pirmohamed; Dean J Naisbitt; Fraser Gordon; B Kevin Park
The danger hypothesis--potential role in idiosyncratic drug reactions.
Toxicology 2002;181-182():55-63.
2002: Bridget Maher; Ana Alfirevic; F Javier Vilar; Edmund G L Wilkins; B Kevin Park; Munir Pirmohamed
TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy.
AIDS (London, England) 2002;16(15):2013-8.
2002: Dean J Naisbitt; John Farrell; S Fraser Gordon; James L Maggs; Christoph Burkhart; Werner J Pichler; Munir Pirmohamed; B Kevin Park
Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation.
Molecular pharmacology 2002;62(3):628-37.
2002: Kenneth F Ilett; Brian T Ethell; James L Maggs; Timothy Davis; Kevin Batty; Brian Burchell; Tran Quang Binh; Le Thi Anh Thu; Nguyen Canh Hung; Munir Pirmohamed; B Kevin Park; Geoffrey Edwards
Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(9):1005-12.
2002: Sally Morrison-Griffiths; Michael A Snowden; Munir Pirmohamed
Pre-registration nurse education in pharmacology: is it adequate for the roles that nurses are expected to fulfil?
Nurse education today 2002;22(6):447-56.
2002: Dominic P Williams; Neil R Kitteringham; Dean J Naisbitt; Munir Pirmohamed; D A Smith; B Kevin Park
Are chemically reactive metabolites responsible for adverse reactions to drugs?
Current drug metabolism 2002;3(4):351-66.
2001: Andrew Owen; Justice Tettey; Paul Morgan; Munir Pirmohamed; B K Park
LC determination of carbamazepine in murine brain.
Journal of pharmaceutical and biomedical analysis 2001;26(4):573-7.
2001: Dean J Naisbitt; Dominic P Williams; Munir Pirmohamed; Neil R Kitteringham; B Kevin Park
Reactive metabolites and their role in drug reactions.
Current opinion in allergy and clinical immunology 2001;1(4):317-25.
2001: Munir Pirmohamed; B Kevin Park
HIV and drug allergy.
Current opinion in allergy and clinical immunology 2001;1(4):311-6.
2001: Justice Tettey; James L Maggs; W G Rapeport; Munir Pirmohamed; B Kevin Park
Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
Chemical research in toxicology 2001;14(8):965-74.
2001: Ricky A Sharma; H R McLelland; KA Hill; Christopher R Ireson; Stephanie A Euden; Margaret M Manson; Munir Pirmohamed; Lawrence J Marnett; Andreas J Gescher; William P Steward
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1894-900.
2001: Dean J Naisbitt; S Fraser Gordon; Munir Pirmohamed; Christoph Burkhart; A E Cribb; Werner J Pichler; B Kevin Park
Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo.
British journal of pharmacology 2001;133(2):295-305.
2001: Munir Pirmohamed; K Lin; David W Chadwick; B Kevin Park
TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients.
Neurology 2001;56(7):890-6.
2001: Andrew Owen; Munir Pirmohamed; Justice Tettey; Paul Morgan; David W Chadwick; B Kevin Park
Carbamazepine is not a substrate for P-glycoprotein.
British journal of clinical pharmacology 2001;51(4):345-9.
2001: B Kevin Park; Munir Pirmohamed
Toxicogenetics in drug development.
Toxicology letters 2001;120(1-3):281-91.
2001: B Kevin Park; Dean J Naisbitt; S Fraser Gordon; Neil R Kitteringham; Munir Pirmohamed
Metabolic activation in drug allergies.
Toxicology 2001;158(1-2):11-23.
2001: Munir Pirmohamed; D J Back
The pharmacogenomics of HIV therapy.
The pharmacogenomics journal 2001;1(4):243-53.
2000: Dean J Naisbitt; F Javier Vilar; Anne C Stalford; Ed G L Wilkins; Munir Pirmohamed; B Kevin Park
Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.
AIDS research and human retroviruses 2000;16(18):1929-38.
2000: Dean J Naisbitt; S Fraser Gordon; Munir Pirmohamed; B Kevin Park
Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment.
Drug safety : an international journal of medical toxicology and drug experience 2000;23(6):483-507.
2000: B Kevin Park; Neil R Kitteringham; Helen Powell; Munir Pirmohamed
Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity.
Toxicology 2000;153(1-3):39-60.
2000: Munir Pirmohamed; Ana Alfirevic; J Vilar; Anne C Stalford; Ed G L Wilkins; E Sim; B Kevin Park
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity.
Pharmacogenetics 2000;10(8):705-13.
2000: James L Maggs; Dean J Naisbitt; Justice Tettey; Munir Pirmohamed; B Kevin Park
Metabolism of lamotrigine to a reactive arene oxide intermediate.
Chemical research in toxicology 2000;13(11):1075-81.
2000: Neil R Kitteringham; Helen Powell; Y N Clement; Charlotte C Dodd; Justice Tettey; Munir Pirmohamed; D A Smith; L I McLellan; B Kevin Park
Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase.
Hepatology (Baltimore, Md.) 2000;32(2):321-33.
2000: Munir Pirmohamed
Commentary-bisphosphonates and calcium homoeostasis.
Postgraduate medical journal 2000;76(897):418-9.
2000: Dominic P Williams; Munir Pirmohamed; Dean J Naisbitt; Jack P Uetrecht; B Kevin Park
Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine.
Molecular pharmacology 2000;58(1):207-16.
2000: B Schnyder; Christoph Burkhart; K Schnyder-Frutig; Salome von Greyerz; Dean J Naisbitt; Munir Pirmohamed; B Kevin Park; Werner J Pichler
Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6647-54.
2000: Bridget Maher; Peter Carey; Munir Pirmohamed
A simple sore throat?
Hospital medicine (London, England : 1998) 2000;61(6):435.
2000: Lynn Owens; Ian T Gilmore; Munir Pirmohamed
General practice nurses' knowledge of alcohol use and misuse: a questionnaire survey.
Alcohol and alcoholism (Oxford, Oxfordshire) 2000;35(3):259-62.
2000: Munir Pirmohamed; C Brown; Lynn Owens; C Luke; Ian T Gilmore; Alasdair M Breckenridge; B Kevin Park
The burden of alcohol misuse on an inner-city general hospital.
QJM : monthly journal of the Association of Physicians 2000;93(5):291-5.
2000: Munir Pirmohamed; Ian T Gilmore
Alcohol abuse and the burden on the NHS--time for action.
Journal of the Royal College of Physicians of London 2000;34(2):161-2.
2000: Sally Morrison-Griffiths; Munir Pirmohamed
Specialist nurse reporting of adverse drug reactions.
Professional nurse (London, England) 2000;15(5):300-4.
1999: Sally Morrison-Griffiths; M Newman; C O'Mahony; Munir Pirmohamed
Haemolytic anaemia associated with indinavir.
Postgraduate medical journal 1999;75(883):313-5.
1999: Munir Pirmohamed; B Kevin Park
The adverse effects of drugs.
Hospital medicine (London, England : 1998) 1999;60(5):348-52.
1999: Dean J Naisbitt; S J Hough; HJ Gill; Munir Pirmohamed; Neil R Kitteringham; B Kevin Park
Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.
British journal of pharmacology 1999;126(6):1393-407.
1999: HJ Gill; John F Tjia; Neil R Kitteringham; Munir Pirmohamed; David J Back; B Kevin Park
The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation.
Pharmacogenetics 1999;9(1):43-53.
1998: B Kevin Park; Paul M O'Neill; James L Maggs; Munir Pirmohamed
Safety assessment of peroxide antimalarials: clinical and chemical perspectives.
British journal of clinical pharmacology 1998;46(6):521-9.
1998: Dean J Naisbitt; Dominic P Williams; Paul M O'Neill; James L Maggs; D J Willock; Munir Pirmohamed; B Kevin Park
Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.
Chemical research in toxicology 1998;11(12):1586-95.
1998: Helen Powell; Neil R Kitteringham; Munir Pirmohamed; D A Smith; B Kevin Park
Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype.
Pharmacogenetics 1998;8(5):411-21.
1998: B K Park; Munir Pirmohamed; N R Kitteringham
Role of drug disposition in drug hypersensitivity: a chemical, molecular, and clinical perspective.
Chemical research in toxicology 1998;11(9):969-88.
1998: M De Sousa; Munir Pirmohamed; Neil R Kitteringham; Thomas Woolf; B Kevin Park
No association between tacrine transaminitis and the glutathione transferase theta genotype in patients with Alzheimer's disease.
Pharmacogenetics 1998;8(4):353-5.
1998: Munir Pirmohamed; Alasdair M Breckenridge; Neil R Kitteringham; B Kevin Park
Adverse drug reactions.
BMJ (Clinical research ed.) 1998;316(7140):1295-8.
1998: D S Almond; Lesley E Rhodes; Munir Pirmohamed
Risperidone-induced photosensitivity.
Postgraduate medical journal 1998;74(870):252-3.
1998: Sally Morrison-Griffiths; Munir Pirmohamed; Thomas J Walley
Reporting of adverse drug reactions: practice in the UK.
Nursing times 1998;94(10):52-4.
1997: Dominic P Williams; Munir Pirmohamed; Dean J Naisbitt; James L Maggs; B Kevin Park
Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1375-82.
1997: Munir Pirmohamed; Neil R Kitteringham; B K Park
Polymorphism in gene for microsomal epoxide hydrolase and lung disease.
Lancet 1997;350(9090):1553-4.
1997: C Brown; Munir Pirmohamed; B Kevin Park
Nurses' confidence in caring for patients with alcohol-related problems.
Professional nurse (London, England) 1997;13(2):83-6.
1997: MD Tingle; R Mahmud; James L Maggs; Munir Pirmohamed; B Kevin Park
Comparison of the metabolism and toxicity of dapsone in rat, mouse and man.
The Journal of pharmacology and experimental therapeutics 1997;283(2):817-23.
1997: HJ Gill; S J Hough; Dean J Naisbitt; James L Maggs; Neil R Kitteringham; Munir Pirmohamed; B Kevin Park
The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat.
The Journal of pharmacology and experimental therapeutics 1997;282(2):795-801.
1997: James L Maggs; Munir Pirmohamed; Neil R Kitteringham; B Kevin Park
Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(3):275-80.
1997: Dean J Naisbitt; J E Ruscoe; D Williams; Paul M O'Neill; Munir Pirmohamed; B Kevin Park
Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.
The Journal of pharmacology and experimental therapeutics 1997;280(2):884-93.
1996: A S Wilson; C D Davis; Dominic P Williams; Alan R Buckpitt; Munir Pirmohamed; B Kevin Park
Characterisation of the toxic metabolite(s) of naphthalene.
Toxicology 1996;114(3):233-42.
1996: Munir Pirmohamed; S Madden; B Kevin Park
Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism.
Clinical pharmacokinetics 1996;31(3):215-30.
1996: H J Gill; James L Maggs; S Madden; Munir Pirmohamed; B Kevin Park
The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole.
British journal of clinical pharmacology 1996;42(3):347-53.
1996: Neil R Kitteringham; C Davis; N Howard; Munir Pirmohamed; B Kevin Park
Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1018-27.
1996: B Kevin Park; Neil R Kitteringham; Munir Pirmohamed; Geoffrey T Tucker
Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications.
British journal of clinical pharmacology 1996;41(6):477-91.
1996: Munir Pirmohamed; D Williams; MD Tingle; M Barry; Saye H Khoo; C O'Mahony; Edmund G L Wilkins; Alasdair M Breckenridge; B Kevin Park
Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency.
AIDS (London, England) 1996;10(5):501-7.
1996: Munir Pirmohamed; M J Wild; Neil R Kitteringham; K O'Brien; I E Buchan; D J Back; B K Park
Lack association between schizophrenia and the CYP2D6 gene polymorphisms.
American journal of medical genetics 1996;67(2):236-7.
1995: Munir Pirmohamed; Neil R Kitteringham; L J Quest; R L Allott; V J Green; I T Gilmore; B Kevin Park
Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians.
Pharmacogenetics 1995;5(6):351-7.
1995: James L Maggs; D Williams; Munir Pirmohamed; B Kevin Park
The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1463-75.
1995: C D Davis; Munir Pirmohamed; Neil R Kitteringham; R L Allott; D Smith; B Kevin Park
Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients. Assessment by radiometric HPLC.
Biochemical pharmacology 1995;50(9):1361-6.
1995: V J Green; Munir Pirmohamed; Neil R Kitteringham; A Gaedigk; Denis M Grant; M Boxer; B Burchell; B Kevin Park
Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.
Biochemical pharmacology 1995;50(9):1353-9.
1995: V J Green; Munir Pirmohamed; Neil R Kitteringham; M J Knapp; B Kevin Park
Glutathione S-transferase mu genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis.
British journal of clinical pharmacology 1995;39(4):411-5.
1995: Munir Pirmohamed; D Williams; S Madden; E Templeton; B Kevin Park
Metabolism and bioactivation of clozapine by human liver in vitro.
The Journal of pharmacology and experimental therapeutics 1995;272(3):984-90.
1995: B Kevin Park; Munir Pirmohamed; Neil R Kitteringham
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Pharmacology & therapeutics 1995;68(3):385-424.
1994: B Kevin Park; Munir Pirmohamed; M D Tingle; S Madden; Neil R Kitteringham
Bioactivation and bioinactivation of drugs and drug metabolites: Relevance to adverse drug reactions.
Toxicology in vitro : an international journal published in association with BIBRA 1994;8(4):613-21.
1994: Munir Pirmohamed; Neil R Kitteringham; B K Park
The role of active metabolites in drug toxicity.
Drug safety : an international journal of medical toxicology and drug experience 1994;11(2):114-44.
1994: Munir Pirmohamed; R Allott; V J Green; Neil R Kitteringham; David W Chadwick; B Kevin Park
Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy.
British journal of clinical pharmacology 1994;37(6):577-81.
1993: MD Tingle; Munir Pirmohamed; E Templeton; A S Wilson; S Madden; Neil R Kitteringham; B Kevin Park
An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes.
Biochemical pharmacology 1993;46(9):1529-38.
1993: Munir Pirmohamed; M D Coleman; D Galvani; R C Bucknall; Alasdair M Breckenridge; B Kevin Park
Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis.
British journal of rheumatology 1993;32(3):222-6.
1992: Munir Pirmohamed; Neil R Kitteringham; A M Breckenridge; B Kevin Park
The effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes.
Biochemical pharmacology 1992;44(12):2307-14.
1992: B Kevin Park; Munir Pirmohamed; Neil R Kitteringham
Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.
British journal of clinical pharmacology 1992;34(5):377-95.
1992: Munir Pirmohamed; Neil R Kitteringham; TM Guenthner; Alasdair M Breckenridge; B Kevin Park
An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro.
Biochemical pharmacology 1992;43(8):1675-82.
1992: Munir Pirmohamed; Neil R Kitteringham; Alasdair M Breckenridge; B Kevin Park
Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.
British journal of clinical pharmacology 1992;33(2):183-6.
1992: Munir Pirmohamed; Neil R Kitteringham; B Kevin Park
Idiosyncratic reactions to antidepressants: a review of the possible mechanisms and predisposing factors.
Pharmacology & therapeutics 1992;53(1):105-25.
1991: Munir Pirmohamed; A Graham; P Roberts; D Smith; David W Chadwick; Alasdair M Breckenridge; B Kevin Park
Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.
British journal of clinical pharmacology 1991;32(6):741-9.
1991: Munir Pirmohamed; M D Coleman; F Hussain; Alasdair M Breckenridge; B Kevin Park
Direct and metabolism-dependent toxicity of sulphasalazine and its principal metabolites towards human erythrocytes and leucocytes.
British journal of clinical pharmacology 1991;32(3):303-10.