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Tuula Pirttilä

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T Tukiainen; O Gröhn; Per-Henrik Groop; M Hallikainen; P Jylänki; Kimmo Kaski; M Kivipelto; Ville-Petteri Mäkinen; Tuula Pirttilä; Markku Savolainen; H Soininen; Pasi Soininen; Mika Ala-Korpela
Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses.
Elina M Sutinen; George Anderson; Tuula Pirttilä; Antero Salminen; Johanna O Ojala
Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells.
Kristiina Karttunen; Pertti Karppi; Asta Hiltunen; Matti Vanhanen; Tarja Välimäki; Janne Martikainen; Hannu Valtonen; Juhani Sivenius; Hilkka Soininen; Sirpa Hartikainen; Jaana Suhonen; Tuula Pirttilä
Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease.

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All Publications

2012: T Tukiainen; O Gröhn; Per-Henrik Groop; M Hallikainen; P Jylänki; Kimmo Kaski; M Kivipelto; Ville-Petteri Mäkinen; Tuula Pirttilä; Markku Savolainen; H Soininen; Pasi Soininen; Mika Ala-Korpela
Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses.
The journal of nutrition, health & aging 2012;16(7):631-5.
2012: Elina M Sutinen; George Anderson; Tuula Pirttilä; Antero Salminen; Johanna O Ojala
Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells.
Journal of neuroinflammation 2012;9():199.
2011: Kristiina Karttunen; Pertti Karppi; Asta Hiltunen; Matti Vanhanen; Tarja Välimäki; Janne Martikainen; Hannu Valtonen; Juhani Sivenius; Hilkka Soininen; Sirpa Hartikainen; Jaana Suhonen; Tuula Pirttilä
Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease.
International journal of geriatric psychiatry 2011;26(5):473-82.
2011: Anna-Maija Tolppanen; Seppo Helisalmi; Mikko Hiltunen; Marjukka Kolehmainen; Ursula S Schwab; Tuula Pirttilä; Leena Pulkkinen; Matti Uusitupa; Hilkka Soininen
Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort.
Neurobiology of aging 2011;32(3):546.e7-9.
2010: Ville Leinonen; Anne M Koivisto; S Savolainen; Jaana Rummukainen; Juuso N Tamminen; Tomi Tillgren; Sannakaisa Vainikka; Okko T Pyykkö; Juhani Mölsä; Mikael Fraunberg; Tuula Pirttilä; Juha E Jääskeläinen; Hilkka Soininen; Jaakko Rinne; Irina Alafuzoff
Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease.
Annals of neurology 2010;68(4):446-53.
2010: Minna A Korolainen; Tuula A Nyman; Tero Aittokallio; Tuula Pirttilä
An update on clinical proteomics in Alzheimer's research.
Journal of neurochemistry 2010;112(6):1386-414.
2010: Eveliina Jakkula; Virpi Leppä; Anna-Maija Sulonen; Teppo Varilo; Suvi Kallio; Anu Kemppinen; Shaun Purcell; Keijo Koivisto; Pentti J Tienari; Marja-Liisa Sumelahti; Irina Elovaara; Tuula Pirttilä; Mauri Reunanen; Arpo Aromaa; Annette Bang Oturai; Helle Bach Søndergaard; Hanne F Harbo; Inger-Lise Mero; Stacey B Gabriel; Daniel B Mirel; Stephen L Hauser; Ludwig Kappos; Chris Polman; Philip L De Jager; David A Hafler; Mark J Daly; Aarno Palotie; Janna Saarela; Leena Peltonen
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
American journal of human genetics 2010;86(2):285-91.
2010: Vilmantas Giedraitis; Anna Glaser; Timo Sarajärvi; RoseMarie Brundin; Malin Degerman Gunnarsson; Brit-Maren Schjeide; Rudolph E Tanzi; Seppo Helisalmi; Tuula Pirttilä; Lena Kilander; Lars Lannfelt; Hilkka Soininen; Lars Bertram; Martin Ingelsson; Mikko Hiltunen
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.
Neuroscience letters 2010;469(2):265-7.
2010: Jaana Suhonen; Tuula Pirttilä; Timo Erkinjuntti; Hannu Koponen; Markku Makkonen; Marja Puurunen; Minna Raivio; Juha Rinne; Ari Rosenvall; Timo Strandberg; Ritva Vanninen; Risto Vataja
[Update on current care guidelines. The diagnosis and medical treatment of memory disorders].
Duodecim; lääketieteellinen aikakauskirja 2010;126(18):2167-8.
2010: Tuomo Hänninen; Veijo Pulliainen; Mona Sotaniemi; Laura Hokkanen; Juhani Salo; Marja Hietanen; Tuula Pirttilä; Minna Pöyhönen; Kati Juva; Anne Remes; Timo Erkinjuntti
[Early detection of cognitive changes in memory diseases: new cut-off scores for the Finnish version of CERAD neuropsychological battery].
Duodecim; lääketieteellinen aikakauskirja 2010;126(17):2013-21.
2010: Sari Rastas; Tuula Pirttilä; Kari Mattila; Auli Verkkoniemi; Kati Juva; Leena Niinistö; Esko Länsimies; Raimo Sulkava
Vascular risk factors and dementia in the general population aged >85 years: prospective population-based study.
Neurobiology of aging 2010;31(1):1-7.
2009: Saila Vepsäläinen; Seppo Helisalmi; Arto Mannermaa; Tuula Pirttilä; Hilkka Soininen; Mikko Hiltunen
Combined risk effects of IDE and NEP gene variants on Alzheimer disease.
Journal of neurology, neurosurgery, and psychiatry 2009;80(11):1268-70.
2009: Johanna Palmio; Jaana Suhonen; Tapani Keränen; Janne Hulkkonen; Jukka Peltola; Tuula Pirttilä
Cerebrospinal fluid tau as a marker of neuronal damage after epileptic seizure.
Seizure : the journal of the British Epilepsy Association 2009;18(7):474-7.
2009: Niklas Mattsson; Henrik Zetterberg; Oskar Hansson; Niels Andreasen; Lucilla Parnetti; Michael Jonsson; Sanna-Kaisa Herukka; Wiesje M van der Flier; Marinus A Blankenstein; Michael Ewers; Kenneth Rich; Elmar Kaiser; Marcel Verbeek; Magda Tsolaki; Ezra Mulugeta; Erik Rosén; Dag Aarsland; Pieter Jelle Visser; Johannes Schröder; Jan Marcusson; Mony de Leon; Harald Hampel; Philip scheltens; Tuula Pirttilä; Anders Wallin; Maria Eriksdotter Jönhagen; Lennart Minthon; Bengt Winblad; Kaj Blennow
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
JAMA : the journal of the American Medical Association 2009;302(4):385-93.
2009: Anu Kemppinen; Minna Suvela; Pentti J Tienari; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Ilkka Rautakorpi; Jan Hillert; Frida Lundmark; Annette Oturai; Lars Ryder; Hanne F Harbo; Elisabeth G Celius; Aarno Palotie; Mark J Daly; Leena Peltonen; Janna Saarela
MYO9B polymorphisms in multiple sclerosis.
European journal of human genetics : EJHG 2009;17(6):840-3.
2009: Suvi P Kallio; Eveliina Jakkula; Shaun Purcell; Minna Suvela; Keijo Koivisto; Pentti J Tienari; Irina Elovaara; Tuula Pirttilä; Mauri Reunanen; Denis Bronnikov; Markku Viander; Seppo Meri; Jan Hillert; Frida Lundmark; Hanne F Harbo; Aslaug R Lorentzen; Philip L De Jager; Mark J Daly; David A Hafler; Aarno Palotie; Leena Peltonen; Janna Saarela
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.
Human molecular genetics 2009;18(9):1670-83.
2009: Alessandro Bonetti; Keijo Koivisto; Tuula Pirttilä; Irina Elovaara; Mauri Reunanen; Mikko Laaksonen; Juhani Ruutiainen; Leena Peltonen; Terhi Rantamäki; Pentti J Tienari
A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility.
Journal of neuroimmunology 2009;208(1-2):119-24.
2009: Tero Tapiola; Irina Alafuzoff; Sanna-Kaisa Herukka; Laura Parkkinen; Päivi Hartikainen; Hilkka Soininen; Tuula Pirttilä
Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.
Archives of neurology 2009;66(3):382-9.
2009: Johanna Ojala; Irina Alafuzoff; Sanna-Kaisa Herukka; Thomas van Groen; Heikki Tanila; Tuula Pirttilä
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
Neurobiology of aging 2009;30(2):198-209.
2009: Anna-Maija Sulonen; Suvi P Kallio; Pekka Ellonen; Minna Suvela; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Pentti J Tienari; Aarno Palotie; Leena Peltonen; Janna Saarela
No evidence for shared etiology in two demyelinative disorders, MS and PLOSL.
Journal of neuroimmunology 2009;206(1-2):86-90.
2009: Anne Remes; Mika Leikola; Kari Majamaa; Matti Nikkanen; Lotta-Iiris Ruokonen; Minna Rusanen; Tero Tapiola; Pauli Ylikotila; Anna-Maija Vallittu; Tuula Pirttilä
[Use of CSF biomarkers in the diagnostics of memory diseases].
Duodecim; lääketieteellinen aikakauskirja 2009;125(20):2215-22.
2009: Minna A Korolainen; Tuula Pirttilä
Cerebrospinal fluid, serum and plasma protein oxidation in Alzheimer's disease.
Acta neurologica Scandinavica 2009;119(1):32-8.
2008: Johanna O Ojala; Elina M Sutinen; Antero Salminen; Tuula Pirttilä
Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells.
Journal of neuroimmunology 2008;205(1-2):86-93.
2008: Taru Tukiainen; Tuulia Tynkkynen; Ville-Petteri Mäkinen; Pasi Jylänki; Antti Kangas; Johanna Hokkanen; Aki Vehtari; Olli Gröhn; Merja Hallikainen; Hilkka Soininen; Miia Kivipelto; Per-Henrik Groop; Kimmo Kaski; Reino Laatikainen; Pasi Soininen; Tuula Pirttilä; Mika Ala-Korpela
A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease.
Biochemical and biophysical research communications 2008;375(3):356-61.
2008: Ville Leinonen; Irina Alafuzoff; Sargo Aalto; Timo Suotunen; S Savolainen; Kjell Någren; Tero Tapiola; Tuula Pirttilä; Jaakko Rinne; Juha E Jääskeläinen; Hilkka Soininen; Juha O Rinne
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.
Archives of neurology 2008;65(10):1304-9.
2008: R Lämsä; Seppo Helisalmi; Sanna-Kaisa Herukka; Tero Tapiola; Tuula Pirttilä; Saila Vepsäläinen; M Hiltunen; Hilkka Soininen
Genetic study evaluating LDLR polymorphisms and Alzheimer's disease.
Neurobiology of aging 2008;29(6):848-55.
2008: Sanna-Kaisa Herukka; Corina Pennanen; Hilkka Soininen; Tuula Pirttilä
CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy.
Journal of Alzheimer's disease : JAD 2008;14(1):51-7.
2008: Roger Lane; Howard H Feldman; Joanne Meyer; Yunsheng He; Steven H Ferris; agneta nordberg; Taher Darreh-Shori; Hilkka Soininen; Tuula Pirttilä; Martin R Farlow; Nikolaos Sfikas; Clive G Ballard; Nigel H Greig
Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease.
Pharmacogenetics and genomics 2008;18(4):289-98.
2008: Laura Parkkinen; Tuula Pirttilä; Irina Alafuzoff
Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance.
Acta neuropathologica 2008;115(4):399-407.
2007: R Lämsä; Seppo Helisalmi; Mikko Hiltunen; Sanna-Kaisa Herukka; Tero Tapiola; Tuula Pirttilä; Saila Vepsäläinen; Hilkka Soininen
The association study between DHCR24 polymorphisms and Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(7):906-10.
2007: Katharina Buerger; Irina Alafuzoff; Michael Ewers; Tuula Pirttilä; Raymond Zinkowski; Harald Hampel
No correlation between CSF tau protein phosphorylated at threonine 181 with neocortical neurofibrillary pathology in Alzheimer's disease.
Brain : a journal of neurology 2007;130(Pt 10):e82.
2007: Sari Rastas; Auli Verkkoniemi; Tuomo Polvikoski; Kati Juva; Leena Niinistö; Kari Mattila; Esko Länsimies; Tuula Pirttilä; Raimo Sulkava
Atrial fibrillation, stroke, and cognition: a longitudinal population-based study of people aged 85 and older.
Stroke; a journal of cerebral circulation 2007;38(5):1454-60.
2007: Minna A Korolainen; Tuula A Nyman; Paula Nyyssönen; E Samuel Hartikainen; Tuula Pirttilä
Multiplexed proteomic analysis of oxidation and concentrations of cerebrospinal fluid proteins in Alzheimer disease.
Clinical chemistry 2007;53(4):657-65.
2007: Sanna-Kaisa Herukka; Seppo Helisalmi; Merja Hallikainen; Susanna Tervo; Hilkka Soininen; Tuula Pirttilä
CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI.
Neurobiology of aging 2007;28(4):507-14.
2006: Katharina Buerger; Michael Ewers; Tuula Pirttilä; Raymond Zinkowski; Irina Alafuzoff; Stefan J Teipel; John DeBernardis; Daniel Kerkman; Cheryl McCulloch; Hilkka Soininen; Harald Hampel
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease.
Brain : a journal of neurology 2006;129(Pt 11):3035-41.
2006: Sari Rastas; Tuula Pirttilä; Petteri Viramo; Auli Verkkoniemi; Pirjo Halonen; Kati Juva; Leena Niinistö; Kari Mattila; Esko Länsimies; Raimo Sulkava
Association between blood pressure and survival over 9 years in a general population aged 85 and older.
Journal of the American Geriatrics Society 2006;54(6):912-8.
2006: Tuula Pirttilä; Asla Pitkänen
Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat.
Neuroscience letters 2006;395(2):108-13.
2006: Juhani Ruutiainen; Irina Elovaara; Tuula Pirttilä; Juha-Pekka Erälinna; Markus Färkkilä; Keijo Koivisto; Mauri Reunanen
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2006;122(18):2181-2.
2006: Minna A Korolainen; Gundars Goldsteins; Tuula A Nyman; Irina Alafuzoff; Jari Koistinaho; Tuula Pirttilä
Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain.
Neurobiology of aging 2006;27(1):42-53.
2005: H M F Riise Stensland; Janna Saarela; Denis O Bronnikov; Maija Parkkonen; Anne Jokiaho; Aarno Palotie; Pentti J Tienari; Marja-Liisa Sumelahti; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Eric Sobel; Leena Peltonen
Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12.
Journal of neuroimmunology 2005;170(1-2):122-33.
2005: Laura Parkkinen; Tuula Pirttilä; Markku Tervahauta; Irina Alafuzoff
Widespread and abundant alpha-synuclein pathology in a neurologically unimpaired subject.
Neuropathology : official journal of the Japanese Society of Neuropathology 2005;25(4):304-14.
2005: H J Frey; Kari M Mattila; Minna A Korolainen; Tuula Pirttilä
Problems associated with biological markers of Alzheimer's disease.
Neurochemical research 2005;30(12):1501-10.
2005: Minna A Korolainen; Seppo Auriola; Tuula A Nyman; Irina Alafuzoff; Tuula Pirttilä
Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brain.
Neurobiology of disease 2005;20(3):858-70.
2005: Tuula Pirttilä; Katarzyna Lukasiuk; Katarina Håkansson; Anders Grubb; Magnus Abrahamson; Asla Pitkänen
Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse.
Neurobiology of disease 2005;20(2):241-53.
2005: Tuula Pirttilä; Anni Manninen; Leena Jutila; Jari Nissinen; Reetta Kälviäinen; Matti Vapalahti; Arto Immonen; Leo Paljärvi; Kari Karkola; Irina Alafuzoff; Esa Mervaala; Asla Pitkänen
Cystatin C expression is associated with granule cell dispersion in epilepsy.
Annals of neurology 2005;58(2):211-23.
2005: Sanna-Kaisa Herukka; Merja Hallikainen; Hilkka Soininen; Tuula Pirttilä
CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment.
Neurology 2005;64(7):1294-7.
2005: Soininen Hilkka; Tuula Pirttilä
[Are Alzheimer's drugs effective?].
Duodecim; lääketieteellinen aikakauskirja 2005;121(4):345-6.
2005: Laura Parkkinen; Tarja Kauppinen; Tuula Pirttilä; Jaana M Autere; Irina Alafuzoff
Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia.
Annals of neurology 2005;57(1):82-91.
2004: Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons.
Neuroscience letters 2004;368(2):181-5.
2004: Janne A Martikainen; Hannu Valtonen; Tuula Pirttilä
Potential cost-effectiveness of a family-based program in mild Alzheimer's disease patients.
The European journal of health economics : HEPAC : health economics in prevention and care 2004;5(2):136-42.
2004: Tuula Pirttilä; Sampsa Vanhatalo; Ursula Turpeinen; Raili Riikonen
Cerebrospinal fluid insulin-like growth factor-1, insulin growth factor binding protein-2 or nitric oxide are not increased in MS or ALS.
Acta neurologica Scandinavica 2004;109(5):337-41.
2004: Tuula Pirttilä; Taina Nybo
[Pain and cognition].
Duodecim; lääketieteellinen aikakauskirja 2004;120(2):199-205.
2003: Susanna Narkilahti; Tuula Pirttilä; Katarzyna Lukasiuk; Jarkko Tuunanen; Asla Pitkänen
Expression and activation of caspase 3 following status epilepticus in the rat.
The European journal of neuroscience 2003;18(6):1486-96.
2003: Katharina Buerger; Raymond Zinkowski; Stefan J Teipel; Hiroyuki Arai; John DeBernardis; Daniel Kerkman; Cheryl McCulloch; Frank Padberg; Frank Faltraco; Alexander Goernitz; Tero Tapiola; Stanley I Rapoport; Tuula Pirttilä; Hans-Jürgen Möller; Harald Hampel
Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231.
The American journal of psychiatry 2003;160(2):376-9.
2002: Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
Biochemical and biophysical research communications 2002;298(5):693-8.
2002: Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.
Brain research. Molecular brain research 2002;106(1-2):50-6.
2002: Janna Saarela; Marlena Schoenberg Fejzo; Daniel Chen; Saara Finnilä; Maija Parkkonen; Satu Kuokkanen; Eric Sobel; Pentti J Tienari; Marja-Liisa Sumelahti; Juhani Wikström; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Aarno Palotie; Leena Peltonen
Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24.
Human molecular genetics 2002;11(19):2257-67.
2002: Minna A Korolainen; Gundars Goldsteins; Irina Alafuzoff; Jari Koistinaho; Tuula Pirttilä
Proteomic analysis of protein oxidation in Alzheimer's disease brain.
Electrophoresis 2002;23(19):3428-33.
2002: Katharina Buerger; Raymond Zinkowski; Stefan J Teipel; Tero Tapiola; Hiroyuki Arai; Kaj Blennow; Niels Andreasen; Klaus Hofmann-Kiefer; John DeBernardis; Daniel Kerkman; Cheryl McCulloch; Russell Kohnken; Frank Padberg; Tuula Pirttilä; Mark B Schapiro; Stanley I Rapoport; Hans-Jürgen Möller; Peter Davies; Harald Hampel
Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231.
Archives of neurology 2002;59(8):1267-72.
2002: Kirsi Niiranen; Marko Pietilä; Tuula Pirttilä; Aki Järvinen; Maria Halmekytö; Veli-Pekka Korhonen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues.
The Journal of biological chemistry 2002;277(28):25323-8.
2002: Katarzyna Lukasiuk; Tuula Pirttilä; Asla Pitkänen
Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy.
Epilepsia 2002;43 Suppl 5():137-45.
2001: Tero Tapiola; Hilkka Soininen; Tuula Pirttilä
CSF tau and Abeta42 levels in patients with Down's syndrome.
Neurology 2001;56(7):979-80.
2001: Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis.
Biochemical and biophysical research communications 2001;280(4):998-1002.
2001: Petri Kerokoski; Hilkka Soininen; Tuula Pirttilä
Beta-amyloid (1-42) affects MTT reduction in astrocytes: implications for vesicular trafficking and cell functionality.
Neurochemistry international 2001;38(2):127-34.
2001: Irina Elovaara; M Färkkilä; A Hietaharju; Tuula Pirttilä
[Use of immunoglobulin in the therapy of neurological illnesses].
Duodecim; lääketieteellinen aikakauskirja 2001;117(10):1033-41; quiz 1041, 1081.
2000: Tero Tapiola; Tuula Pirttilä; Pankaj D Mehta; I Alafuzofff; Maarit Lehtovirta; Hilkka Soininen
Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease.
Neurobiology of aging 2000;21(5):735-40.
2000: Tuula Pirttilä; M Haanpää; Pankaj D Mehta; T Lehtimäki
Apolipoprotein E (APOE) phenotype and APOE concentrations in multiple sclerosis and acute herpes zoster.
Acta neurologica Scandinavica 2000;102(2):94-8.
2000: Tero Tapiola; Tuula Pirttilä; Mia Mikkonen; Pankaj D Mehta; Irina Alafuzoff; Keijo Koivisto; Hilkka Soininen
Three-year follow-up of cerebrospinal fluid tau, beta-amyloid 42 and 40 concentrations in Alzheimer's disease.
Neuroscience letters 2000;280(2):119-22.
2000: Irina Elovaara; Tuula Pirttilä
[Corticosteroids in the treatment of multiple sclerosis and optic neuritis].
Duodecim; lääketieteellinen aikakauskirja 2000;116(15):1547-54.
2000: Pankaj D Mehta; Tuula Pirttilä; Sangita P Mehta; Eugene A Sersen; Paul S Aisen; Henryk M Wisniewski
Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease.
Archives of neurology 2000;57(1):100-5.
1998: Kari M Mattila; Charlotte Forsell; Tuula Pirttilä; J O Rinne; T Lehtimäki; Matias Röyttä; Lena Lilius; A Eerola; Peter St George-Hyslop; H Frey; Lars Lannfelt
The Glu318Gly mutation of the presenilin-1 gene does not necessarily cause Alzheimer's disease.
Annals of neurology 1998;44(6):965-7.
1998: Tuula Pirttilä; Keijo Koivisto; Pankaj D Mehta; Kari Reinikainen; K S Kim; O Kilkku; EH Heinonen; Hilkka Soininen; PJ Riekkinen; Henryk M Wisniewski
Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer's disease.
Neuroscience letters 1998;249(1):21-4.
1997: Tuula Pirttilä; Hilkka Soininen; Pankaj D Mehta; Outi Kopra; T Lehtimäki; Nenad Bogdanovic; L Paljärvi; K S Kim; O Kosunen; Bengt Winblad; PJ Riekkinen; Henryk M Wisniewski
Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains.
Neurobiology of aging 1997;18(1):121-7.
1996: A Chauhan; Tuula Pirttilä; P Mehta; Ved P S Chauhan; Henryk M Wisniewski
Effect of cerebrospinal fluid from normal and Alzheimer's patients with different apolipoprotein E phenotypes on in vitro aggregation of amyloid beta-protein.
Journal of the neurological sciences 1996;141(1-2):54-8.
1996: Juhana M Hakumäki; Olli H J Gröhn; Tuula Pirttilä; Risto A Kauppinen
Increased macromolecular resonances in the rat cerebral cortex during severe energy failure as detected by 1H nuclear magnetic resonance spectroscopy.
Neuroscience letters 1996;212(3):151-4.
1996: Tuula Pirttilä; Hilkka Soininen; Outi Kopra; T Lehtimäki; Nenad Bogdanovic; Leo Paljärvi; O Kosunen; Bengt Winblad; PJ Riekkinen; Henryk M Wisniewski; Pankaj D Mehta
Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls.
Brain research 1996;722(1-2):71-7.
1996: Tuula Pirttilä; T Lehtimäki; J Rinne; K Mattila; H Frey; T Nikkari
The frequency of apolipoprotein E4 allele is not increased in patients with probable vascular dementia.
Acta neurologica Scandinavica 1996;93(5):352-4.
1996: Tuula Pirttilä; Pankaj D Mehta; Hilkka Soininen; K S Kim; Outi Kopra; Leo Paljärvi; O Kosunen; PJ Riekkinen; Henryk M Wisniewski
Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease: correlations with amyloid load in the brain.
Archives of neurology 1996;53(2):189-93.
1995: Terho Lehtimäki; Tuula Pirttilä; H Frey; T Nikkari
[Alzheimer's disease and the association of genetic polymorphism of apolipoprotein E and liquor beta protein in Finns].
Duodecim; lääketieteellinen aikakauskirja 1995;111(5):401-7.
1995: Terho Lehtimäki; Tuula Pirttilä; P D Mehta; Henryk M Wisniewski; H Frey; T Nikkari
Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease.
Human genetics 1995;95(1):39-42.
1995: Tuula Pirttilä; Seppo Auriola; Risto A Kauppinen
Glucose metabolism in the developing cerebral cortex as detected by 1H(13C) nuclear magnetic resonance spectroscopy ex vivo.
Journal of neurochemistry 1995;64(1):417-23.
1994: Tuula Pirttilä; K S Kim; Pankaj D Mehta; H Frey; Henryk M Wisniewski
Soluble amyloid beta-protein in the cerebrospinal fluid from patients with Alzheimer's disease, vascular dementia and controls.
Journal of the neurological sciences 1994;127(1):90-5.
1994: Tuula Pirttilä; Risto A Kauppinen
Lactate efflux and intracellular pH during severe hypoxia in rat cerebral cortex in vitro studied by nuclear magnetic resonance spectroscopy.
Neuroscience letters 1994;178(1):111-4.
1994: K M Mattila; Tuula Pirttilä; Kaj Blennow; Anders Wallin; Matti Viitanen; H Frey
Altered blood-brain-barrier function in Alzheimer's disease?
Acta neurologica Scandinavica 1994;89(3):192-8.
1994: Risto A Kauppinen; Tuula Pirttilä; Seppo Auriola; S R Williams
Compartmentation of cerebral glutamate in situ as detected by 1H/13C n.m.r.
The Biochemical journal 1994;298 ( Pt 1)():121-7.
1994: Tuula Pirttilä; Risto A Kauppinen
Regulation of intracellular pH in guinea pig cerebral cortex ex vivo studied by 31P and 1H nuclear magnetic resonance spectroscopy: role of extracellular bicarbonate and chloride.
Journal of neurochemistry 1994;62(2):656-64.
1993: Tuula Pirttilä; Risto A Kauppinen
Extracellular pH and buffering power determine intracellular pH in cortical brain slices during and following hypoxia.
Neuroreport 1993;5(3):213-6.
1993: Tuula Pirttilä; R Järvenpää; Prasun Dastidar; H Frey
Brain atrophy in neurodegenerative diseases. Quantitative and qualitative CT analysis.
Acta radiologica (Stockholm, Sweden : 1987) 1993;34(3):296-302.
1993: Tuula Pirttilä; Juhana M Hakumäki; Risto A Kauppinen
1H nuclear magnetic resonance spectroscopy study of cerebral glutamate in an ex vivo brain preparation of guinea pig.
Journal of neurochemistry 1993;60(4):1274-82.
1993: K J Brooks; Tuula Pirttilä; Risto A Kauppinen
Delayed increase in intracellular Na+ in cerebral cortical slices during severe hypoxia as measured by double quantum filtered 23Na+ NMR.
Neuroreport 1993;4(2):139-42.
1992: Risto A Kauppinen; T Nissinen; A M Kärkkäinen; Tuula Pirttilä; J Palvimo; H Kokko; S R Williams
Detection of thymosin beta 4 in situ in a guinea pig cerebral cortex preparation using 1H NMR spectroscopy.
The Journal of biological chemistry 1992;267(14):9905-10.
1992: Tuula Pirttilä; R Järvenpää; P Laippala; H Frey
Brain atrophy on computerized axial tomography scans: interaction of age, diabetes and general morbidity.
Gerontology 1992;38(5):285-91.
1992: Tuula Pirttilä; Risto A Kauppinen
Recovery of intracellular pH in cortical brain slices following anoxia studied by nuclear magnetic resonance spectroscopy: role of lactate removal, extracellular sodium and sodium/hydrogen exchange.
Neuroscience 1992;47(1):155-64.
1991: O Raatikainen; Risto A Kauppinen; Hannu Komulainen; Hannu Taipale; Tuula Pirttilä; J Tuomisto
Polyene antibiotics increase the ionic permeability of synaptosomal plasma membranes.
Biochemical pharmacology 1991;41(9):1345-50.
1991: Tuula Pirttilä; K Mattila; H Frey
CSF proteins in neurological disorders analyzed by immobilized PH gradient isoelectric focusing using narrow PH gradients.
Acta neurologica Scandinavica 1991;83(1):34-40.
1990: K Mattila; Tuula Pirttilä; H Frey
Horizontal two-dimensional electrophoresis of cerebrospinal fluid proteins with immobilized pH gradients in the first dimension.
Electrophoresis 1990;11(1):91-2.