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Asla Pitkänen
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40
Riekkinen, PJ
27
Nissinen, Jari
21
Halonen, Toivo
16
Lukasiuk, Katarzyna
15
Partanen, Kaarina
15
Ylinen, Aarne
15
Kälviäinen, Reetta
12
Gröhn, Olli
12
Soininen, Hilkka
11
Mervaala, Esa
11
Jolkkonen, Jukka
10
Jolkkonen, Esa
10
Amaral, David
9
Miettinen, Riitta
9
Partanen, Juhani
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All Publications
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2009: Marklund N; Morales D; Clausen F; Hånell A; Kiwanuka O; Pitkänen A; Gimbel D A; Philipson O; Lannfelt L; Hillered L; Strittmatter S M; McIntosh T K
Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice.
Neuroscience 2009;163(2):540-51.
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2009: Lahtinen L; Huusko N; Myöhänen H; Lehtivarjo A-K; Pellinen R; Turunen M P; Ylä-Herttuala S; Pirinen E; Pitkänen A
Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus.
Neuroscience 2009;163(1):316-28.
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2009: Kharatishvili Irina; Sierra Alejandra; Immonen Riikka J; Gröhn Olli H J; Pitkänen Asla
Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat.
Experimental neurology 2009;217(1):154-64.
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2009: Noé Francesco; Frasca Angelisa; Balducci Claudia; Carli Mirjana; Sperk Gunther; Ferraguti Francesco; Pitkänen Asla; Bland Ross; Fitzsimons Helen; During Matthew; Vezzani Annamaria
Neuropeptide Y overexpression using recombinant adeno-associated viral vectors.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(2):300-6.
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2009: Kriegstein Arnold R; Pitkänen Asla
Commentary: the prospect of cell-based therapy for epilepsy.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(2):295-9.
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2009: Minkeviciene Rimante; Rheims Sylvain; Dobszay Marton B; Zilberter Misha; Hartikainen Jarmo; Fülöp Lívia; Penke Botond; Zilberter Yuri; Harkany Tibor; Pitkänen Asla; Tanila Heikki
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3453-62.
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2009: Majak K; Dabrowski M; Pitkänen A
Epileptogenesis alters gene expression pattern in rats subjected to amygdala-dependent emotional learning.
Neuroscience 2009;159(2):468-82.
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2009: Immonen Riikka J; Kharatishvili Irina; Gröhn Heidi; Pitkänen Asla; Gröhn Olli H J
Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury.
NeuroImage 2009;45(1):1-9.
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2009: Pitkänen A; Hätönen H; Kuosmanen L; Välimäki M
Individual quality of life of people with severe mental disorders.
Journal of psychiatric and mental health nursing 2009;16(1):3-9.
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2009: Pitkänen Asla; Immonen Riikka J; Gröhn Olli H J; Kharatishvili Irina
From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options.
Epilepsia 2009;50 Suppl 2():21-9.
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2009: Pitkänen Asla; Lukasiuk Katarzyna
Molecular and cellular basis of epileptogenesis in symptomatic epilepsy.
Epilepsy & behavior : E&B 2009;14 Suppl 1():16-25.
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2008: Noè Francesco; Pool Allan-Hermann; Nissinen Jari; Gobbi Marco; Bland Ross; Rizzi Massimo; Balducci Claudia; Ferraguti Francesco; Sperk Gunther; During Matthew J; Pitkänen Asla; Vezzani Annamaria
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy.
Brain : a journal of neurology 2008;131(Pt 6):1506-15.
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2008: Immonen Riikka J; Kharatishvili Irina; Sierra Alejandra; Einula Christine; Pitkänen Asla; Gröhn Olli H J
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus.
NeuroImage 2008;40(4):1718-30.
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2007: Kharatishvili Irina; Immonen Riikka; Gröhn Olli; Pitkänen Asla
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis.
Brain : a journal of neurology 2007;130(Pt 12):3155-68.
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2007: Karhunen H; Bezvenyuk Z; Nissinen J; Sivenius J; Jolkkonen J; Pitkänen A
Epileptogenesis after cortical photothrombotic brain lesion in rats.
Neuroscience 2007;148(1):314-24.
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2007: Goffin Karolien; Nissinen Jari; Van Laere Koen; Pitkänen Asla
Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat.
Experimental neurology 2007;205(2):501-5.
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2007: Pitkänen Asla; Mathiesen Claus; Rønn Lars Christian B; Møller Arne; Nissinen Jari
Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.
Epilepsy research 2007;74(1):45-54.
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2007: Noe' Francesco; Nissinen Jari; Pitkänen Asla; Gobbi Marco; Sperk Gunther; During Matthew; Vezzani Annamaria
Gene therapy in epilepsy: the focus on NPY.
Peptides 2007;28(2):377-83.
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2007: Nissinen Jari; Pitkänen Asla
Effect of antiepileptic drugs on spontaneous seizures in epileptic rats.
Epilepsy research 2007;73(2):181-91.
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2007: Siiskonen Hanna; Oikari Sanna; Korhonen Veli-Pekka; Pitkänen Asla; Voikar Vootele; Kettunen Mikko; Hakumäki Juhana; Wahlfors Tiina; Pussinen Raimo; Penttonen Markku; Kiehne Karlheinz; Kaasinen Selma K; Alhonen Leena; Jänne Juhani; Herzig Karl-Heinz
Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning.
Molecular and cellular neurosciences 2007;34(2):199-208.
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2007: Lukasiuk Katarzyna; Pitkänen Asla
Gene and protein expression in experimental status epilepticus.
Epilepsia 2007;48 Suppl 8():28-32.
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2007: Gröhn Olli; Pitkänen Asla
Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations.
Epilepsia 2007;48 Suppl 4():3-10.
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2007: Keck Carrie A; Thompson Hilaire J; Pitkänen Asla; LeBold David G; Morales Diego M; Plevy Jamie B; Puri Rishi; Zhao Boyu; Dichter Marc; McIntosh Tracy K
The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury.
Restorative neurology and neuroscience 2007;25(2):77-90.
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2007: Narkilahti Susanna; Jutila Leena; Alafuzoff Irina; Karkola Kari; Paljärvi Leo; Immonen Arto; Vapalahti Matti; Mervaala Esa; Kälviäinen Reetta; Pitkänen Asla
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.
Neuromolecular medicine 2007;9(2):129-44.
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2007: Pitkänen Asla; Kharatishvili Irina; Karhunen Heli; Lukasiuk Katarzyna; Immonen Riikka; Nairismägi Jaak; Gröhn Olli; Nissinen Jari
Epileptogenesis in experimental models.
Epilepsia 2007;48 Suppl 2():13-20.
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2006: Karhunen Heli; Nissinen Jari; Sivenius Juhani; Jolkkonen Jukka; Pitkänen Asla
A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats.
Epilepsy research 2006;72(1):25-38.
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2006: Lahtinen Laura; Lukasiuk Katarzyna; Pitkänen Asla
Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis.
The European journal of neuroscience 2006;24(7):1935-45.
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2006: Pitkänen Asla
New Data Suggest that Discontinuation of Status Epilepticus Is Not Necessary for Antiepileptogenic Effect in Immature Brain.
Epilepsy currents / American Epilepsy Society 2006;6(5):170-2.
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2006: Kharatishvili I; Nissinen J P; McIntosh T K; Pitkänen A
A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats.
Neuroscience 2006;140(2):685-97.
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2006: Kemppainen E J Samuli; Nissinen Jari; Pitkänen Asla
Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy.
Epilepsia 2006;47(5):820-9.
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2006: Nairismägi Jaak; Pitkänen Asla; Kettunen Mikko I; Kauppinen Risto A; Kubova Hana
Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: a histologic and MRI study.
Epilepsia 2006;47(3):479-88.
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2006: Pirttilä Terhi J; Pitkänen Asla
Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat.
Neuroscience letters 2006;395(2):108-13.
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2006: Nairismägi Jaak; Pitkänen Asla; Narkilahti Susanna; Huttunen Joanna; Kauppinen Risto A; Gröhn Olli H J
Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo.
NeuroImage 2006;30(1):130-5.
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2006: Pitkänen Asla; McIntosh Tracy K
Animal models of post-traumatic epilepsy.
Journal of neurotrauma 2006;23(2):241-61.
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2006: Lukasiuk Katarzyna; Dabrowski Michal; Adach Alicja; Pitkänen Asla
Epileptogenesis-related genes revisited.
Progress in brain research 2006;158():223-41.
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2005: Karhunen Heli; Jolkkonen Jukka; Sivenius Juhani; Pitkänen Asla
Epileptogenesis after experimental focal cerebral ischemia.
Neurochemical research 2005;30(12):1529-42.
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2005: Pirttilä Terhi J; Lukasiuk Katarzyna; Håkansson Katarina; Grubb Anders; Abrahamson Magnus; Pitkänen Asla
Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse.
Neurobiology of disease 2005;20(2):241-53.
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2005: Pirttilä Terhi J; Manninen Anni; Jutila Leena; Nissinen Jari; Kälviäinen Reetta; Vapalahti Matti; Immonen Arto; Paljärvi Leo; Karkola Kari; Alafuzoff Irina; Mervaala Esa; Pitkänen Asla
Cystatin C expression is associated with granule cell dispersion in epilepsy.
Annals of neurology 2005;58(2):211-23.
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2005: Päivinen Niina; Lammi Seppo; Pitkänen Asla; Nissinen Jari; Penttonen Markku; Grönfors Tapio
Epileptic seizure detection: a nonlinear viewpoint.
Computer methods and programs in biomedicine 2005;79(2):151-9.
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2005: Pitkänen Asla; Gröhn Olli
Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain.
Epilepsy currents / American Epilepsy Society 2005;5(3):98-100.
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2005: Gonçalves Pereira Pedro M; Insausti Ricardo; Artacho-Pérula Emilio; Salmenperä Tuuli; Kälviäinen Reetta; Pitkänen Asla
MR volumetric analysis of the piriform cortex and cortical amygdala in drug-refractory temporal lobe epilepsy.
AJNR. American journal of neuroradiology 2005;26(2):319-32.
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2005: Pitkänen Asla
SV2A: more than just a new target for AEDs.
Epilepsy currents / American Epilepsy Society 2005;5(1):14-6.
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2005: Pitkänen Asla; Kharatishvili Irina; Narkilahti Susanna; Lukasiuk Katarzyna; Nissinen Jari
Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat.
Epilepsy research 2005;63(1):27-42.
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2005: Salmenperä T; Könönen M; Roberts N; Vanninen R; Pitkänen A; Kälviäinen R
Hippocampal damage in newly diagnosed focal epilepsy: a prospective MRI study.
Neurology 2005;64(1):62-8.
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2005: Narkilahti S; Pitkänen A
Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy.
Neuroscience 2005;131(4):887-97.
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2004: Pitkänen Asla
On the way to cure epilepsy.
Expert review of neurotherapeutics 2004;4(6):917-20.
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2004: Pitkänen Asla; Narkilahti Susanna; Bezvenyuk Zinayida; Haapalinna Antti; Nissinen Jari
Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats.
Epilepsy research 2004;61(1-3):119-40.
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2004: Nairismägi Jaak; Gröhn Olli H J; Kettunen Mikko I; Nissinen Jari; Kauppinen Risto A; Pitkänen Asla
Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepsy.
Epilepsia 2004;45(9):1024-34.
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2004: Majak Katarzyna; Rönkkö Seppo; Kemppainen Samuli; Pitkänen Asla
Projections from the amygdaloid complex to the piriform cortex: A PHA-L study in the rat.
The Journal of comparative neurology 2004;476(4):414-28.
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2004: Kubová Hana; Mares Pavel; Suchomelová Lucie; Brozek Gustav; Druga Rastislav; Pitkänen Asla
Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis.
The European journal of neuroscience 2004;19(12):3255-65.
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2004: Lähteinen Sari; Pitkänen Asla; Knuuttila Juha; Törönen Petri; Castrén Eero
Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice.
The European journal of neuroscience 2004;19(12):3245-54.
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2004: Lukasiuk Katarzyna; Pitkänen Asla
Large-scale analysis of gene expression in epilepsy research: is synthesis already possible?
Neurochemical research 2004;29(6):1169-78.
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2004: Pitkänen Asla; Kubova Hana
Antiepileptic drugs in neuroprotection.
Expert opinion on pharmacotherapy 2004;5(4):777-98.
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2004: Nissinen Jari; Large Charles H; Stratton Sharon C; Pitkänen Asla
Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat.
Epilepsy research 2004;58(2-3):119-32.
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2004: Pitkänen Asla
American Epilepsy Society - 57th Annual Meeting.
IDrugs : the investigational drugs journal 2004;7(2):125-7.
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2004: Majak Katarzyna; Pitkänen Asla
Do seizures cause irreversible cognitive damage? Evidence from animal studies.
Epilepsy & behavior : E&B 2004;5 Suppl 1():S35-44.
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2004: Kemppainen S; Pitkänen A
Damage to the amygdalo-hippocampal projection in temporal lobe epilepsy: a tract-tracing study in chronic epileptic rats.
Neuroscience 2004;126(2):485-501.
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2004: Niittykoski M; Nissinen J; Penttonen M; Pitkänen A
Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats.
Neuroscience 2004;124(2):269-81.
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2003: Majak Katarzyna; Pitkänen Asla
Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat.
The European journal of neuroscience 2003;18(6):1652-9.
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2003: Narkilahti Susanna; Pirttilä Terhi J; Lukasiuk Katarzyna; Tuunanen Jarkko; Pitkänen Asla
Expression and activation of caspase 3 following status epilepticus in the rat.
The European journal of neuroscience 2003;18(6):1486-96.
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2003: Laurén Hanna B; Pitkänen Asla; Nissinen Jari; Soini Sanna L; Korpi Esa R; Holopainen Irma E
Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy.
Neuroscience letters 2003;349(1):58-62.
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2003: Griffin Julian L; Lehtimäki Kimmo K; Valonen Piia K; Gröhn Olli H J; Kettunen Mikko I; Ylä-Herttuala Seppo; Pitkänen Asla; Nicholson Jeremy K; Kauppinen Risto A
Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death.
Cancer research 2003;63(12):3195-201.
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2003: Narkilahti S; Nissinen J; Pitkänen A
Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis.
Neuropharmacology 2003;44(8):1068-88.
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2003: Klitgaard Henrik; Pitkänen Asla
Antiepileptogenesis, neuroprotection, and disease modification in the treatment of epilepsy: focus on levetiracetam.
Epileptic disorders : international epilepsy journal with videotape 2003;5 Suppl 1():S9-16.
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2003: Karhunen Heli; Pitkänen Asla; Virtanen Tiina; Gureviciene Irina; Pussinen Raimo; Ylinen Aarne; Sivenius Juhani; Nissinen Jari; Jolkkonen Jukka
Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits.
Epilepsy research 2003;54(1):1-10.
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2003: Pitkänen Asla; Savander Mia; Nurminen Nina; Ylinen Aarne
Intrinsic synaptic circuitry of the amygdala.
Annals of the New York Academy of Sciences 2003;985():34-49.
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2003: Sutula Thomas P; Hagen Joshua; Pitkänen Asla
Do epileptic seizures damage the brain?
Current opinion in neurology 2003;16(2):189-95.
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2003: Pitkänen Asla
Clinical trials in neuroprotection. 23-25 January 2003, Key Biscayne, FL, USA.
IDrugs : the investigational drugs journal 2003;6(3):200-2.
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2003: Lukasiuk Katarzyna; Kontula Laura; Pitkänen Asla
cDNA profiling of epileptogenesis in the rat brain.
The European journal of neuroscience 2003;17(2):271-9.
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2003: Majak Katarzyna; Pitkänen Asia
Projections from the periamygdaloid cortex to the amygdaloid complex, the hippocampal formation, and the parahippocampal region: a PHA-L study in the rat.
Hippocampus 2003;13(8):922-42.
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2003: Lähteinen S; Pitkänen A; Koponen E; Saarelainen T; Castrén E
Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling.
Neuroscience 2003;122(4):1081-92.
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2003: Pitkänen Asla
[On the neurobiology of emotions]
Duodecim; lääketieteellinen aikakauskirja 2003;119(15):1471-8.
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2002: Pitkänen Asla
Drug-mediated neuroprotection and antiepileptogenesis: animal data.
Neurology 2002;59(9 Suppl 5):S27-33.
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2002: Majak Katarzyna; Pikkarainen Maria; Kemppainen Samuli; Jolkkonen Esa; Pitkänen Asla
Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: a Phaseolus vulgaris leucoagglutinin study in the rat.
The Journal of comparative neurology 2002;451(3):236-49.
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2002: Pitkänen Asla; Sutula Thomas P
Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy.
Lancet neurology 2002;1(3):173-81.
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2002: Pitkänen Asla
Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models.
Epilepsy research 2002;50(1-2):141-60.
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2002: Pitkänen Asla; Kemppainen Samuli
Comparison of the distribution of calcium-binding proteins and intrinsic connectivity in the lateral nucleus of the rat, monkey, and human amygdala.
Pharmacology, biochemistry, and behavior 2002;71(3):369-77.
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2002: Lähteinen Sari; Pitkänen Asla; Saarelainen Tommi; Nissinen Jari; Koponen Eija; Castrén Eero
Decreased BDNF signalling in transgenic mice reduces epileptogenesis.
The European journal of neuroscience 2002;15(4):721-34.
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2002: Kemppainen Samuli; Jolkkonen Esa; Pitkänen Asla
Projections from the posterior cortical nucleus of the amygdala to the hippocampal formation and parahippocampal region in rat.
Hippocampus 2002;12(6):735-55.
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2002: Pitkänen Asla; Nissinen Jari; Nairismägi Jaak; Lukasiuk Katarzyna; Gröhn Olli H J; Miettinen Riitta; Kauppinen Risto
Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy.
Progress in brain research 2002;135():67-83.
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2002: Lukasiuk Katarzyna; Pirttilä Terhi J; Pitkänen Asla
Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy.
Epilepsia 2002;43 Suppl 5():137-45.
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2002: Pitkänen Asla; Kelly Jennifer L; Amaral David G
Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the entorhinal cortex in the macaque monkey.
Hippocampus 2002;12(2):186-205.
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2002: Jolkkonen E; Miettinen R; Pikkarainen M; Pitkänen A
Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat.
Neuroscience 2002;111(1):133-49.
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2002: Jutila L; Immonen A; Partanen K; Partanen J; Mervaala E; Ylinen A; Alafuzoff I; Paljärvi L; Karkola K; Vapalahti M; Pitkänen A
Neurobiology of epileptogenesis in the temporal lobe.
Advances and technical standards in neurosurgery 2002;27():5-22.
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2001: Pirttilä T R; Pitkänen A; Tuunanen J; Kauppinen R A
Ex vivo MR microimaging of neuronal damage after kainate-induced status epilepticus in rat: correlation with quantitative histology.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(5):946-54.
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2001: Pikkarainen M; Pitkänen A
Projections from the lateral, basal and accessory basal nuclei of the amygdala to the perirhinal and postrhinal cortices in rat.
Cerebral cortex (New York, N.Y. : 1991) 2001;11(11):1064-82.
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2001: Jutila L; Ylinen A; Partanen K; Alafuzoff I; Mervaala E; Partanen J; Vapalahti M; Vainio P; Pitkänen A
MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug-refractory temporal lobe epilepsy.
AJNR. American journal of neuroradiology 2001;22(8):1490-501.
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2001: Halonen T; Nissinen J; Pitkänen A
Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat.
Epilepsy research 2001;46(3):205-23.
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2001: Salmenperä T; Kälviäinen R; Partanen K; Pitkänen A
Hippocampal and amygdaloid damage in partial epilepsy: a cross-sectional MRI study of 241 patients.
Epilepsy research 2001;46(1):69-82.
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2001: Kubová H; Druga R; Lukasiuk K; Suchomelová L; Haugvicová R; Jirmanová I; Pitkänen A
Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(10):3593-9.
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2001: Jolkkonen E; Miettinen R; Pitkänen A
Projections from the amygdalo-piriform transition area to the amygdaloid complex: a PHA-l study in rat.
The Journal of comparative neurology 2001;432(4):440-65.
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2001: Halonen T; Nissinen J; Pitkänen A
Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats.
Neuropharmacology 2001;40(4):536-50.
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2001: Jolkkonen E; Pikkarainen M; Kemppainen S; Pitkänen A
Interconnectivity between the amygdaloid complex and the amygdalostriatal transition area: a PHA-L study in rat.
The Journal of comparative neurology 2001;431(1):39-58.
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2001: Nissinen J; Lukasiuk K; Pitkänen A
Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?
Hippocampus 2001;11(3):299-310.
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2000: Gröhn OHJ; Kettunen M I; Mäkelä H I; Penttonen M; Pitkänen A; Lukkarinen J A; Kauppinen R A
Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(10):1457-66.
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2000: Kemppainen S; Pitkänen A
Distribution of parvalbumin, calretinin, and calbindin-D(28k) immunoreactivity in the rat amygdaloid complex and colocalization with gamma-aminobutyric acid.
The Journal of comparative neurology 2000;426(3):441-67.
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2000: Salmenperä T; Kälviäinen R; Partanen K; Mervaala E; Pitkänen A
MRI volumetry of the hippocampus, amygdala, entorhinal cortex, and perirhinal cortex after status epilepticus.
Epilepsy research 2000;40(2-3):155-70.
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2000: Pitkänen A; Pikkarainen M; Nurminen N; Ylinen A
Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review.
Annals of the New York Academy of Sciences 2000;911():369-91.
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2000: Lamusuo S; Pitkänen A; Jutila L; Ylinen A; Partanen K; Kälviäinen R; Ruottinen H M; Oikonen V; Någren K; Lehikoinen P; Vapalahti M; Vainio P; Rinne J O
[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.
Neurology 2000;54(12):2252-60.
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2000: Lukasiuk K; Pitkänen A
GABA(A)-mediated toxicity of hippocampal neurons in vitro.
Journal of neurochemistry 2000;74(6):2445-54.
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2000: Salmenperä T; Kälviäinen R; Partanen K; Pitkänen A
Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy.
Seizure : the journal of the British Epilepsy Association 2000;9(3):208-15.
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2000: Tuunanen J; Pitkänen A
Do seizures cause neuronal damage in rat amygdala kindling?
Epilepsy research 2000;39(2):171-6.
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2000: Nissinen J; Halonen T; Koivisto E; Pitkänen A
A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat.
Epilepsy research 2000;38(2-3):177-205.
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2000: Pitkänen A; Nissinen J; Lukasiuk K; Jutila L; Paljärvi L; Salmenperä T; Karkola K; Vapalahti M; Ylinen A
Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy.
Epilepsia 2000;41 Suppl 6():S24-9.
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2000: Pitkänen A; Jolkkonen E; Kemppainen S
Anatomic heterogeneity of the rat amygdaloid complex.
Folia morphologica 2000;59(1):1-23.
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2000: Mikkonen M; Pitkänen A; Soininen H; Alafuzoff I; Miettinen R
Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow.
Neuroscience 2000;96(3):515-22.
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1999: Gröhn O H; Lukkarinen J A; Silvennoinen M J; Pitkänen A; van Zijl P C; Kauppinen R A
Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T(1) in the rotating frame.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;42(2):268-76.
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1999: Halonen T; Nissinen J; Pitkänen A
Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat.
Epilepsy research 1999;34(2-3):251-69.
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1999: Pitkänen A; Nissinen J; Jolkkonen E; Tuunanen J; Halonen T
Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus.
Epilepsy research 1999;33(1):67-85.
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1999: Pikkarainen M; Rönkkö S; Savander V; Insausti R; Pitkänen A
Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat.
The Journal of comparative neurology 1999;403(2):229-60.
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1999: Pitkänen A; Jolkkonen J
Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?
Electroencephalography and clinical neurophysiology. Supplement 1999;50():443-9.
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1999: Tuunanen J; Lukasiuk K; Halonen T; Pitkänen A
Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms.
Neuroscience 1999;94(2):473-95.
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1998: Mikkonen M; Soininen H; Kälviänen R; Tapiola T; Ylinen A; Vapalahti M; Paljärvi L; Pitkänen A
Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex.
Annals of neurology 1998;44(6):923-34.
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1998: Pitkänen A; Tuunanen J; Kälviäinen R; Partanen K; Salmenperä T
Amygdala damage in experimental and human temporal lobe epilepsy.
Epilepsy research 1998;32(1-2):233-53.
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1998: Pitkänen A; Amaral D G
Organization of the intrinsic connections of the monkey amygdaloid complex: projections originating in the lateral nucleus.
The Journal of comparative neurology 1998;398(3):431-58.
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1998: Kälviäinen R; Salmenperä T; Partanen K; Vainio P; Riekkinen P; Pitkänen A
Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy.
Neurology 1998;50(5):1377-82.
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1998: Jolkkonen E; Pitkänen A
Intrinsic connections of the rat amygdaloid complex: projections originating in the central nucleus.
The Journal of comparative neurology 1998;395(1):53-72.
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1998: Insausti R; Juottonen K; Soininen H; Insausti A M; Partanen K; Vainio P; Laakso M P; Pitkänen A
MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices.
AJNR. American journal of neuroradiology 1998;19(4):659-71.
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1998: Sorvari H; Miettinen R; Soininen H; Paljärvi L; Karkola K; Pitkänen A
Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala.
Brain research 1998;783(2):355-8.
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1998: Juottonen K; Laakso M P; Insausti R; Lehtovirta M; Pitkänen A; Partanen K; Soininen H
Volumes of the entorhinal and perirhinal cortices in Alzheimer's disease.
Neurobiology of aging 1998;19(1):15-22.
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1998: Pitkänen A
[Amygdala]
Duodecim; lääketieteellinen aikakauskirja 1998;114(23):2451-9.
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1997: Pitkänen A; Savander V; LeDoux J E
Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala.
Trends in neurosciences 1997;20(11):517-23.
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1997: Mikkonen M; Soininen H; Pitkänen A
Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex.
The Journal of comparative neurology 1997;388(1):64-88.
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1997: Jolkkonen J; Kähkönen K; Pitkänen A
Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus.
Neuroscience 1997;80(2):401-11.
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1997: Kälviäinen R; Salmenperä T; Partanen K; Vainio P; Riekkinen P; Pitkänen A
MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy.
Epilepsy research 1997;28(1):39-50.
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1997: Jolkkonen J; Jolkkonen E; Pitkänen A
Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection.
Experimental neurology 1997;145(1):141-53.
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1997: Savander V; Miettinen R; Ledoux J E; Pitkänen A
Lateral nucleus of the rat amygdala is reciprocally connected with basal and accessory basal nuclei: a light and electron microscopic study.
Neuroscience 1997;77(3):767-81.
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1997: Savander V; Ledoux J E; Pitkänen A
Interamygdaloid projections of the basal and accessory basal nuclei of the rat amygdaloid complex.
Neuroscience 1997;76(3):725-35.
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1997: Miettinen M; Pitkänen A; Miettinen R
Distribution of calretinin-immunoreactivity in the rat entorhinal cortex: coexistence with GABA.
The Journal of comparative neurology 1997;378(3):363-78.
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1997: Tuunanen J; Halonen T; Pitkänen A
Decrease in somatostatin-immunoreactive neurons in the rat amygdaloid complex in a kindling model of temporal lobe epilepsy.
Epilepsy research 1997;26(2):315-27.
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1997: Kälviäinen R; Partanen K; Aikiä M; Mervaala E; Vainio P; Riekkinen P J; Pitkänen A
MRI-based hippocampal volumetry and T2 relaxometry: correlation to verbal memory performance in newly diagnosed epilepsy patients with left-sided temporal lobe focus.
Neurology 1997;48(1):286-7.
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1996: Tuunanen J; Halonen T; Pitkänen A
Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex.
The European journal of neuroscience 1996;8(12):2711-25.
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1996: Kälviäinen R; Aikiä M; Mervaala E; Saukkonen A M; Pitkänen A; Riekkinen P J
Long-term cognitive and EEG effects of tiagabine in drug-resistant partial epilepsy.
Epilepsy research 1996;25(3):291-7.
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1996: Sorvari H; Soininen H; Pitkänen A
Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex.
Neuroscience 1996;75(2):421-43.
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1996: Sorvari H; Miettinen R; Soininen H; Pitkänen A
Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study.
Neuroscience letters 1996;217(2-3):93-6.
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1996: Savander V; Go C G; Ledoux J E; Pitkänen A
Intrinsic connections of the rat amygdaloid complex: projections originating in the accessory basal nucleus.
The Journal of comparative neurology 1996;374(2):291-313.
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1996: Jolkkonen J; Halonen T; Jolkkonen E; Nissinen J; Pitkänen A
Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system.
Neuroreport 1996;7(12):2031-5.
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1996: Savander V; LeDoux J E; Pitkänen A
Topographic projections from the periamygdaloid cortex to select subregions of the lateral nucleus of the amygdala in the rat.
Neuroscience letters 1996;211(3):167-70.
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1996: Pitkänen A; Tuunanen J; Halonen T
Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala.
Epilepsy research 1996;24(1):29-45.
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1996: Sorvari H; Soininen H; Pitkänen A
Calretinin-immunoreactive cells and fibers in the human amygdaloid complex.
The Journal of comparative neurology 1996;369(2):188-208.
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1996: Halonen T; Nissinen J; Jansen J A; Pitkänen A
Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus.
European journal of pharmacology 1996;299(1-3):69-81.
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1995: Savander V; Go C G; LeDoux J E; Pitkänen A
Intrinsic connections of the rat amygdaloid complex: projections originating in the basal nucleus.
The Journal of comparative neurology 1995;361(2):345-68.
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1995: Sorvari H; Soininen H; Paljärvi L; Karkola K; Pitkänen A
Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex.
The Journal of comparative neurology 1995;360(2):185-212.
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1995: Pitkänen A; Stefanacci L; Farb C R; Go G G; LeDoux J E; Amaral D G
Intrinsic connections of the rat amygdaloid complex: projections originating in the lateral nucleus.
The Journal of comparative neurology 1995;356(2):288-310.
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1995: Soininen H; Partanen K; Pitkänen A; Hallikainen M; Hänninen T; Helisalmi S; Mannermaa A; Ryynänen M; Koivisto K; Riekkinen P
Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele.
Neurology 1995;45(2):391-2.
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1995: Pitkänen A; Halonen T
Prevention of neuronal cell death by anticonvulsants in experimental epilepsy (extended abstract).
Acta neurologica Scandinavica. Supplementum 1995;162():22-3.
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1994: Saukkonen A; Kälviäinen R; Partanen K; Vainio P; Riekkinen P; Pitkänen A
Do seizures cause neuronal damage? A MRI study in newly diagnosed and chronic epilepsy.
Neuroreport 1994;6(1):219-23.
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1994: Soininen H S; Partanen K; Pitkänen A; Vainio P; Hänninen T; Hallikainen M; Koivisto K; Riekkinen P J
Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: correlation to visual and verbal memory.
Neurology 1994;44(9):1660-8.
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1994: Pitkänen A; Amaral D G
The distribution of GABAergic cells, fibers, and terminals in the monkey amygdaloid complex: an immunohistochemical and in situ hybridization study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(4):2200-24.
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1993: Pitkänen A; Amaral D G
Distribution of parvalbumin-immunoreactive cells and fibers in the monkey temporal lobe: the hippocampal formation.
The Journal of comparative neurology 1993;331(1):37-74.
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1993: Pitkänen A; Amaral D G
Distribution of parvalbumin-immunoreactive cells and fibers in the monkey temporal lobe: the amygdaloid complex.
The Journal of comparative neurology 1993;331(1):14-36.
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1993: Pitkänen A; Amaral D G
Distribution of calbindin-D28k immunoreactivity in the monkey temporal lobe: the amygdaloid complex.
The Journal of comparative neurology 1993;331(2):199-224.
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1993: Kälviäinen R; Halonen T; Pitkänen A; Riekkinen P J
Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: effect of vigabatrin and carbamazepine monotherapies.
Journal of neurochemistry 1993;60(4):1244-50.
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1993: Pitkänen A; Ylinen A; Matilainen R; Luukkainen R; Mervaala E; Seppänen R; Ruutiainen T; Riekkinen P J
Long-term antiepileptic efficacy of vigabatrin in drug-refractory epilepsy in mentally retarded patients. A 5-year follow-up study.
Archives of neurology 1993;50(1):24-9.
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1992: Stefanacci L; Farb C R; Pitkänen A; Go G; LeDoux J E; Amaral D G
Projections from the lateral nucleus to the basal nucleus of the amygdala: a light and electron microscopic PHA-L study in the rat.
The Journal of comparative neurology 1992;323(4):586-601.
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1992: Ylinen A; Sivenius J; Pitkänen A; Halonen T; Partanen J; Mervaala E; Mumford J P; Riekkinen P J
Gamma-vinyl GABA (vigabatrin) in epilepsy: clinical, neurochemical, and neurophysiologic monitoring in epileptic patients.
Epilepsia 1992;33(5):917-22.
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1992: Nieminen S A; Sirviö J; Teittinen K; Pitkänen A; Airaksinen M M; Riekkinen P
Amygdala kindling increased fear-response, but did not impair spatial memory in rats.
Physiology & behavior 1992;51(4):845-9.
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1992: Halonen T; Pitkänen A; Koivisto E; Partanen J; Riekkinen P J
Effect of vigabatrin on the electroencephalogram in rats.
Epilepsia 1992;33(1):122-7.
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1992: Freund T F; Ylinen A; Miettinen R; Pitkänen A; Lahtinen H; Baimbridge K G; Riekkinen P J
Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability.
Brain research bulletin 1992;28(1):27-38.
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1992: Halonen T; Pitkänen A; Partanen J; Hyttinen J M; Riekkinen P J
Amino acid levels in cerebrospinal fluid of rats after administration of pentylenetetrazol.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1992;101(1):21-5.
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1991: Pitkänen A; Amaral D G
Distribution of reduced nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) cells and fibers in the monkey amygdaloid complex.
The Journal of comparative neurology 1991;313(2):326-48.
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1991: Halonen T; Pitkänen A; Saano V; Riekkinen P J
Effects of vigabatrin (gamma-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats.
Epilepsia 1991;32(2):242-9.
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1991: Pitkänen A; Amaral D G
Demonstration of projections from the lateral nucleus to the basal nucleus of the amygdala: a PHA-L study in the monkey.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1991;83(3):465-70.
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1990: Halonen T; Pitkänen A; Riekkinen P J
Administration of vigabatrin (gamma-vinyl-gamma-aminobutyric acid) affects the levels of both inhibitory and excitatory amino acids in rat cerebrospinal fluid.
Journal of neurochemistry 1990;55(6):1870-4.
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1990: Riekkinen P; Sirviö J; Valjakka A; Pitkänen A; Partanen J; Riekkinen P
The effects of concurrent manipulations of cholinergic and noradrenergic systems on neocortical EEG and spatial learning.
Behavioral and neural biology 1990;54(2):204-10.
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1990: Lahtinen H; Pitkänen A; Tuomisto L; Riekkinen P
Effect of antiepileptic drugs on somatostatin release in vitro.
Neuropeptides 1990;17(1):29-34.
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1990: Riekkinen P J; Pitkänen A
Somatostatin and epilepsy.
Metabolism: clinical and experimental 1990;39(9 Suppl 2):112-5.
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1990: Valjakka A; Sirviö J; Pitkänen A; Riekkinen P J
Brain amines and neocortical EEG in young and aged rats.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1990;96(2):299-304.
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1989: Reinikainen K J; Pitkänen A; Riekkinen P J
2',3'-cyclic nucleotide-3'-phosphodiesterase activity as an index of myelin in the post-mortem brains of patients with Alzheimer's disease.
Neuroscience letters 1989;106(1-2):229-32.
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1989: Pitkänen A; Beal M F; Sirviö J; Swartz K J; Männistö P T; Riekkinen P J
Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats.
Neuropeptides 1989;14(3):197-207.
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1989: Pitkänen A; Hyttinen J M; Riekkinen P J
Effect of cysteamine on somatostatin-like immunoreactivity in the amygdala-kindled rat brain.
Neuropeptides 1989;14(1):11-6.
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1989: Pitkänen A; Valjakka A; Pääkkönen A; Sirviö J; Jousmäki V; Partanen J; Riekkinen P J
Effect of cysteamine on levels of somatostatin-like immunoreactivity and catecholamines and on electroencephalogram in the rat brain.
Neuropeptides 1989;14(1):1-9.
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1989: Pitkänen A; Hyttinen J M; Sirviö J; Jolkkonen J; Sarlund H; Riekkinen P
The levels of somatostatin in the brain and CSF of rat after carbamazepine administration.
Pharmacology & toxicology 1989;64(3):266-71.
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1989: Pitkänen A; Lepola U; Ylinen A; Riekkinen P J
Somatostatin and beta-endorphin levels in cerebrospinal fluid of nonmedicated and medicated patients with epileptic seizures.
Neuropeptides 1989;13(1):9-15.
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1989: Matilainen R; Pitkänen A; Ruutiainen T; Mervaala E; Riekkinen P
Vigabatrin in epilepsy in mentally retarded patients.
British journal of clinical pharmacology 1989;27 Suppl 1():113S-118S.
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1989: Sirviö J; Pitkänen A; Pääkkönen A; Partanen J; Riekkinen P J
Brain cholinergic enzymes and cortical EEG activity in young and old rats.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1989;94(1):277-83.
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1989: Pitkänen A; Matilainen R; Halonen T; Kutvonen R; Hartikainen P; Riekkinen P
Inhibitory and excitatory amino acids in cerebrospinal fluid of chronic epileptic patients.
Journal of neural transmission 1989;76(3):221-30.
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1988: Pitkänen A; Matilainen R; Ruutiainen T; Riekkinen P
Levels of total gamma-aminobutyric acid (GABA), free GABA and homocarnosine in cerebrospinal fluid of epileptic patients before and during gamma-vinyl-GABA (vigabatrin) treatment.
Journal of the neurological sciences 1988;88(1-3):83-93.
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1988: Pitkänen A; Matilainen R; Ruutiainen T; Lehtinen M; Riekkinen P
Effect of vigabatrin (gamma-vinyl GABA) on amino acid levels in CSF of epileptic patients.
Journal of neurology, neurosurgery, and psychiatry 1988;51(11):1395-400.
-
1988: Matilainen R; Pitkänen A; Ruutiainen T; Mervaala E; Sarlund H; Riekkinen P
Effect of vigabatrin on epilepsy in mentally retarded patients: a 7-month follow-up study.
Neurology 1988;38(5):743-7.
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1988: Sivenius J; Pitkänen A; Matilainen R; Ylinen A; Holonen T; Partanen J; Riekkinen P J
Studies on gamma-vinyl-GABA in Kuopio, Finland.
British journal of clinical practice. Supplement 1988;61():31-2.
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1988: Pitkänen A; Jolkkonen J; Aikiä M; Sirviö J; Sivenius J; Riekkinen P J
Somatostatin-like immunoreactivity in cerebrospinal fluid of patients with complex partial epilepsy.
European neurology 1988;28(1):1-5.
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1988: Pitkänen A; Jolkkonen J; Sirviö J; Riekkinen P
Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain in pentylenetetrazol-induced kindling.
Peptides 1988;9 Suppl 1():105-7.
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1988: Riekkinen P J; Pitkänen A; Halonen T; Lehtinen M; Ylinen A; Sivenius J
Effect of gamma-vinyl GABA treatment on cholinergic and aminergic neurotransmission and on cyclic nucleotides in human complex partial epilepsy--a CSF study.
Progress in neuro-psychopharmacology & biological psychiatry 1988;12(1):81-91.
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1987: Pitkänen A; Jolkkonen J; Riekkinen P
Beta-endorphin, somatostatin, and prolactin levels in cerebrospinal fluid of epileptic patients after generalised convulsion.
Journal of neurology, neurosurgery, and psychiatry 1987;50(10):1294-7.
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1987: Airaksinen E M; Koivisto K; Keränen T; Pitkänen A; Riekkinen P J; Oja S S; Marnela K M; Partanen J V; Tokola O; Gothóni G
Biochemical and clinical studies on epileptic patients during two phase I trials with the novel anticonvulsant taltrimide.
Epilepsy research 1987;1(5):308-11.
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1987: Pitkänen A; Riekkinen P J; Halonen T; Ylinen A; Ruutiainen T; Lehtinen M
Amino acid levels in human CSF after generalized seizure.
Journal of neural transmission 1987;70(3-4):313-9.
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