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JE Pitts

Research Profile

Chemicals & Drugs

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Amino Acid Sequences

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Publications

TOP 3
S Geddes; P Holst; J Grotzinger; R Gill; PG Nugent; Pierre De Meyts; A Wollmer; S Wood; JE Pitts
Structure-function studies of an IGF-I analogue that can be chemically cleaved to a two-chain mini-IGF-I.
John Lisgarten; T K Chattopadhyay; JE Pitts; Rex A Palmer; C D Reynolds; M H Dao-Thi; Edilbert Van Driessche; Sonia Beeckmans
Crystallization of Helix pomatia agglutinin (HPA), a protein from the edible snail.
R Gill; C Verma; B Wallach; Birgitte Uraø; JE Pitts; A Wollmer; Pierre De Meyts; S Wood
Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding.

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All Publications

2001: S Geddes; P Holst; J Grotzinger; R Gill; PG Nugent; Pierre De Meyts; A Wollmer; S Wood; JE Pitts
Structure-function studies of an IGF-I analogue that can be chemically cleaved to a two-chain mini-IGF-I.
Protein engineering 2001;14(1):61-5.
1999: John Lisgarten; T K Chattopadhyay; JE Pitts; Rex A Palmer; C D Reynolds; M H Dao-Thi; Edilbert Van Driessche; Sonia Beeckmans
Crystallization of Helix pomatia agglutinin (HPA), a protein from the edible snail.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 11):1903-5.
1999: R Gill; C Verma; B Wallach; Birgitte Uraø; JE Pitts; A Wollmer; Pierre De Meyts; S Wood
Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding.
Protein engineering 1999;12(4):297-303.
1998: M R Groves; Venugopal Dhanaraj; Mohammed O Badasso; PG Nugent; JE Pitts; DJ Hoover; Tom L Blundell
A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure.
Protein engineering 1998;11(10):833-40.
1998: A Albert; Tom L Blundell; Venugopal Dhanaraj; L E Donate; Michael Groves; K Guruprasad; PG Nugent; P Orprayoon; JE Pitts; S Rufino; N Srinivasan; M Williams; J Wilsher
Protein engineering aspartic proteinases. Site-directed mutagenesis, biochemical characterisation, and X-ray analysis of chymosins with substituted single amino acid substitutions and loop replacements.
Advances in experimental medicine and biology 1998;436():169-77.
1997: M G Williams; J Wilsher; PG Nugent; A Mills; Venugopal Dhanaraj; M Fabry; J Sedlácek; J M Uusitalo; M E Penttila; JE Pitts; Tom L Blundell
Mutagenesis, biochemical characterization and X-ray structural analysis of point mutants of bovine chymosin.
Protein engineering 1997;10(9):991-7.
1996: PG Nugent; A Albert; P Orprayoon; J Wilsher; JE Pitts; Tom L Blundell; Venugopal Dhanaraj
Protein engineering loops in aspartic proteinases: site-directed mutagenesis, biochemical characterization and X-ray analysis of chymosin with a replaced loop from rhizopuspepsin.
Protein engineering 1996;9(10):885-93.
1995: R R Dhanaraj; JE Pitts; PG Nugent; P Orprayoon; Jonathan B Cooper; Tom L Blundell; J Uusitalo; Merja Penttilä
Protein engineering of surface loops: preliminary X-ray analysis of the CHY155-165RHI mutant.
Advances in experimental medicine and biology 1995;362():95-9.
1995: JE Pitts; M D Crawford; PG Nugent; R T Wester; Jonathan B Cooper; A Mantyla; R Fagerstrom; H Nevalainen
The three-dimensional X-ray crystal structure of the aspartic proteinase native to Trichoderma reesei complexed with a renin inhibitor CP-80794.
Advances in experimental medicine and biology 1995;362():543-7.
1993: JE Pitts; J M Uusitalo; D Mantafounis; PG Nugent; D D Quinn; P Orprayoon; Merja Penttilä
Expression and characterisation of chymosin pH optima mutants produced in Trichoderma reesei.
Journal of biotechnology 1993;28(1):69-83.
1992: JE Pitts; Venugopal Dhanaraj; C G Dealwis; D Mantafounis; PG Nugent; P Orprayoon; Jonathan B Cooper; M Newman; Tom L Blundell
Multidisciplinary cycles for protein engineering: site-directed mutagenesis and X-ray structural studies of aspartic proteinases.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1992;210():39-50.
1991: JE Pitts; D Quinn; J Uusitalo; Merja Penttilä
Protein engineering of chymosin and expression in Trichoderma reesei.
Biochemical Society transactions 1991;19(3):663-6.
1991: D Quinn; JE Pitts; D Mantafounis; S E Lawler; J Uusitalo; Merja Penttilä; P Strop
Modifying the substrate specificity of chymosin.
Biochemical Society transactions 1991;19(3):267S.
1991: JE Pitts; D Mantafounis
Engineering the pH profile of chymosin.
Biochemical Society transactions 1991;19(3):266S.
1991: P Orprayoon; JE Pitts; PG Nugent; D Mantafounis; S E Lawler; Tom L Blundell; J Uusitalo; Merja Penttilä
Protein engineering of the surface loops of chymosin.
Biochemical Society transactions 1991;19(3):265S.
1991: S E Lawler; JE Pitts; D Mantafounis; R Gill; J Uusitalo; Merja Penttilä
Secretion of a chymosin-insulin fusion in Trichoderma reesei.
Biochemical Society transactions 1991;19(3):248S.
1990: JE Pitts; D Mantafounis
Protein engineering of chymosin--tailoring the pH profile.
Biochemical Society transactions 1990;18(5):920-1.
1990: J Husain; Tom L Blundell; S Cooper; JE Pitts; Ian Tickle; Steve P Wood; V J Hruby; Angeliki Buku; A J Fischman; H R Wyssbrod
The conformation of deamino-oxytocin: X-ray analysis of the 'dry' and 'wet' forms.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1243):625-54.
1989: Tom L Blundell; G Elliott; S P Gardner; Tim Hubbard; S Islam; M Johnson; D Mantafounis; P Murray-Rust; J Overington; JE Pitts
Protein engineering and design.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1989;324(1224):447-60.
1986: M Bajaj; T L Blundell; richard horuk; JE Pitts; Steve P Wood; L K Gowan; Christian Schwabe; Axel Wollmer; J Gliemann; S Gammeltoft
Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin.
The Biochemical journal 1986;238(2):345-51.
1986: Steve P Wood; Ian Tickle; A M Treharne; JE Pitts; Y Mascarenhas; J Y Li; J Husain; S Cooper; Tom L Blundell; V J Hruby
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Science (New York, N.Y.) 1986;232(4750):633-6.
1985: I D Glover; David S Moss; Ian Tickle; JE Pitts; I Haneef; Steve P Wood; T L Blundell
Anisotropic thermal motion and polypeptide secondary structure studied by X-ray analysis at 0.98A resolution.
Advances in biophysics 1985;20():1-12.
1984: I D Glover; D J Barlow; JE Pitts; Steve P Wood; Ian Tickle; T L Blundell; K Tatemoto; J R Kimmel; Axel Wollmer; W Strassburger
Conformational studies on the pancreatic polypeptide hormone family.
European journal of biochemistry / FEBS 1984;142(2):379-85.
1983: S A Chawdhury; E J Dodson; G G Dodson; C D Reynolds; S P Tolley; T L Blundell; Anne Cleasby; JE Pitts; Ian Tickle; S P Wood
The crystal structures of three non-pancreatic human insulins.
Diabetologia 1983;25(6):460-4.
1983: M Bajaj; T L Blundell; JE Pitts; Steve P Wood; M A Tatnell; S Falkmer; S O Emdin; L K Gowan; H Crow; Christian Schwabe
Dogfish insulin. Primary structure, conformation and biological properties of an elasmobranchial insulin.
European journal of biochemistry / FEBS 1983;135(3):535-42.
1983: W Strassburger; Axel Wollmer; JE Pitts; I D Glover; Ian Tickle; T L Blundell; G J Steffens; W A Günzler; F Otting; Leopold Flohé
Adaptation of plasminogen activator sequences to known protease structures.
FEBS letters 1983;157(2):219-23.
1982: W Strassburger; U Glatter; Axel Wollmer; Jörg Fleischhauer; D A Mercola; T L Blundell; I Glover; JE Pitts; Ian Tickle; Steve P Wood
Calculated tyrosyl circular dichroism of proteins: absence of tryptophan and cystine interferences in avian pancreatic polypeptide.
FEBS letters 1982;139(2):295-9.
1982: T L Blundell; JE Pitts; Steve P Wood
The conformation and molecular biology of pancreatic hormones and homologous growth factors.
CRC critical reviews in biochemistry 1982;13(2):141-213.
1981: Tom L Blundell; JE Pitts; Ian Tickle; Steve P Wood; C W Wu
X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4175-9.
1981: T L Blundell; JE Pitts; Ian Tickle; Steve P Wood
The conformation and receptor binding of pancreatic hormones.
Biochemical Society transactions 1981;9(1):31-2.
1980: JE Pitts; Steve P Wood; L Hearn; Ian Tickle; C W Wu; T L Blundell; I C Robinson
Crystallisation and preliminary crystallographic data of a porcine neurophysin I-Tyr-Phe-NH2 complex.
FEBS letters 1980;121(1):41-3.