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Gabriel Plaa

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TOP 3
Marie-Yvonne Akoume; Beatriz Tuchweber; Gabriel L Plaa; Ibrahim M Yousef
The role of mdr2 in manganese-bilirubin induced cholestasis in mice.
Marie-Yvonne Akoume; Shahid Perwaiz; Ibrahim M Yousef; Gabriel L Plaa
Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats.
Marie-Yvonne Ndong-Akoume; Diane Mignault; Shahid Perwaiz; Gabriel L Plaa; Ibrahim M Yousef
Simultaneous evaluation of HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities by electrospray tandem MS.

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All Publications

2004: Marie-Yvonne Akoume; Beatriz Tuchweber; Gabriel L Plaa; Ibrahim M Yousef
The role of mdr2 in manganese-bilirubin induced cholestasis in mice.
Toxicology letters 2004;148(1-2):41-51.
2003: Marie-Yvonne Akoume; Shahid Perwaiz; Ibrahim M Yousef; Gabriel L Plaa
Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):378-85.
2002: Marie-Yvonne Ndong-Akoume; Diane Mignault; Shahid Perwaiz; Gabriel L Plaa; Ibrahim M Yousef
Simultaneous evaluation of HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities by electrospray tandem MS.
Lipids 2002;37(11):1101-7.
2001: Gabriel L Plaa
Toxicologists and the founding of the society of toxicology.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(1):3-5.
2000: A Mottino; Beatriz Tuchweber; Gabriel L Plaa; Ibrahim M Yousef
Role of perivenous hepatocytes in taurolithocholate-induced cholestasis in vivo.
Toxicology letters 2000;116(1-2):69-77.
2000: Gabriel L Plaa
Chlorinated methanes and liver injury: highlights of the past 50 years.
Annual review of pharmacology and toxicology 2000;40():42-65.
2000: AB Duguay; Ibrahim M Yousef; Gabriel L Plaa
Manganese-bilirubin effect on cholesterol accumulation in rat bile canalicular membranes.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(1):150-5.
1998: A Faci; Gabriel L Plaa; M Sharkawi
Chloral hydrate enhances ethanol-induced inhibition of methanol oxidation in mice.
Toxicology 1998;131(1):1-7.
1998: AB Duguay; Ibrahim M Yousef; Beatriz Tuchweber; Gabriel L Plaa
Alteration of lipid composition of hepatic membranes associated with manganese-bilirubin induced cholestasis.
Fundamental & clinical pharmacology 1998;12(2):213-9.
1997: AB Duguay; Gabriel L Plaa
Altered cholesterol synthesis as a mechanism involved in methyl isobutyl ketone-potentiated experimental cholestasis.
Toxicology and applied pharmacology 1997;147(2):281-8.
1997: P Raymond; Gabriel L Plaa
Effect of dosing vehicle on the hepatotoxicity of CCl4 and nephrotoxicity of CHCl3 in rats.
Journal of toxicology and environmental health 1997;51(5):463-76.
1997: Ibrahim M Yousef; Guylaine Bouchard; Beatriz Tuchweber; Gabriel L Plaa
Monohydroxy bile acid induced cholestasis: role of biotransformation.
Drug metabolism reviews 1997;29(1-2):167-81.
1997: Gabriel L Plaa
The Snider Address. A four-decade adventure in experimental liver injury.
Drug metabolism reviews 1997;29(1-2):1-37.
1997: AB Duguay; Gabriel L Plaa
Ketone potentiation of intrahepatic cholestasis: effect of two aliphatic isomers.
Journal of toxicology and environmental health 1997;50(1):41-52.
1996: P Raymond; Gabriel L Plaa
Ketone potentiation of haloalkane-induced hepatotoxicity: CCl4 and ketone treatment on hepatic membrane integrity.
Journal of toxicology and environmental health 1996;49(3):285-300.
1996: Pierre Moffatt; Gabriel L Plaa; Francine Denizeau
Rat hepatocytes with elevated metallothionein expression are resistant to N-methyl-N'-nitro-N-nitrosoguanidine cytotoxicity.
Toxicology and applied pharmacology 1996;136(1):200-7.
1995: P Raymond; Gabriel L Plaa
Ketone potentiation of haloalkane-induced hepato- and nephrotoxicity. II. Implication of monooxygenases.
Journal of toxicology and environmental health 1995;46(3):317-28.
1995: Y Li; Ibrahim M Yousef; Gabriel L Plaa
1-Naphthyl isocyanate and 1-naphthylamine as metabolites of 1-naphthylisothiocyanate.
Liver 1995;15(5):271-5.
1995: P Raymond; Gabriel L Plaa
Ketone potentiation of haloalkane-induced hepato- and nephrotoxicity. I. Dose-response relationships.
Journal of toxicology and environmental health 1995;45(4):465-80.
1995: Pierre Moffatt; Gabriel L Plaa; Francine Denizeau
Induction of metallothionein gene expression by epidermal growth factor and its inhibition by transforming growth factor-beta and dexamethasone in rat hepatocytes.
Hepatology (Baltimore, Md.) 1995;21(4):1038-44.
1995: AB Duguay; Gabriel L Plaa
Tissue concentrations of methyl isobutyl ketone, methyl n-butyl ketone and their metabolites after oral or inhalation exposure.
Toxicology letters 1995;75(1-3):51-8.
1994: M Sharkawi; C Granvil; A Faci; Gabriel L Plaa
Pharmacodynamic and metabolic interactions between ethanol and two industrial solvents (methyl n-butyl ketone and methyl isobutyl ketone) and their principal metabolites in mice.
Toxicology 1994;94(1-3):187-95.
1994: Serge Dionne; Beatriz Tuchweber; Gabriel L Plaa; Ibrahim M Yousef
Phase I and phase II metabolism of lithocholic acid in hepatic acinar zone 3 necrosis. Evaluation in rats by combined radiochromatography and gas-liquid chromatography-mass spectrometry.
Biochemical pharmacology 1994;48(6):1187-97.
1994: C P Granvil; M Sharkawi; Gabriel L Plaa
Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice.
Toxicology letters 1994;70(3):263-7.
1993: AB Duguay; Gabriel L Plaa
Plasma concentrations in methyl isobutyl ketone-potentiated experimental cholestasis after inhalation or oral administration.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;21(2):222-7.
1992: L Dahlström-King; Jacques Couture; Gabriel L Plaa
Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis.
Toxicology letters 1992;63(3):243-52.
1992: D D Vu; Beatriz Tuchweber; Gabriel L Plaa; Ibrahim M Yousef
Do intracellular Ca2+ activity and hepatic glutathione play a role in the pathogenesis of lithocholic acid-induced cholestasis?
Toxicology letters 1992;61(2-3):255-64.
1992: Kannan Krishnan; Jules Brodeur; Gabriel L Plaa; Michel Charbonneau
Modulation of hexachlorobenzene-induced hepatic porphyria by methyl isobutyl ketone in the rat.
Toxicology letters 1992;61(2-3):167-74.
1992: D D Vu; Beatriz Tuchweber; Gabriel L Plaa; Ibrahim M Yousef
Pathogenesis of lithocholate-induced intrahepatic cholestasis: role of glucuronidation and hydroxylation of lithocholate.
Biochimica et biophysica acta 1992;1126(1):53-9.
1992: L D Joseph; Ibrahim M Yousef; Gabriel L Plaa; M Sharkawi
Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone.
Toxicology letters 1992;61(1):39-47.
1992: Robert Tardif; Gabriel L Plaa; Jules Brodeur
Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats.
Canadian journal of physiology and pharmacology 1992;70(3):385-93.
1991: Michel Charbonneau; E Greselin; Jules Brodeur; Gabriel L Plaa
Influence of acetone on the severity of the liver injury induced by haloalkane mixtures.
Canadian journal of physiology and pharmacology 1991;69(12):1901-7.
1991: Michel Charbonneau; Jacques Couture; Gabriel L Plaa
Inhalation versus oral administration of acetone: effect of the vehicle on the potentiation of CCl4-induced liver injury.
Toxicology letters 1991;57(1):47-54.
1991: L Dahlström-King; Jacques Couture; Gabriel L Plaa
Functional changes of the biliary tree associated with experimentally induced cholestasis: sulfobromophthalein on manganese-bilirubin combinations.
Toxicology and applied pharmacology 1991;108(3):559-67.
1991: Robert Tardif; S Laparé; Gabriel L Plaa; Jules Brodeur
Effect of simultaneous exposure to toluene and xylene on their respective biological exposure indices in humans.
International archives of occupational and environmental health 1991;63(4):279-84.
1990: Serge Dionne; P Russo; Beatriz Tuchweber; Gabriel L Plaa; Ibrahim M Yousef
Cholic acid and chenodeoxycholic acid transport in the hepatic acinus in rats. Effect of necrosis of zone 3 induced by bromobenzene.
Liver 1990;10(6):336-42.
1990: M Vézina; A B Kobusch; Patrick Du Souich; E Greselin; Gabriel L Plaa
Potentiation of chloroform-induced hepatotoxicity by methyl isobutyl ketone and two metabolites.
Canadian journal of physiology and pharmacology 1990;68(8):1055-61.
1990: L Dahlström-King; Patrick Du Souich; Jacques Couture; Gabriel L Plaa
The influence of severity of bile flow reduction, cycloheximide, and methyl isobutyl ketone pretreatment on the kinetics of taurolithocholic acid disposition in the rat.
Toxicology and applied pharmacology 1990;104(2):312-21.
1990: L Dahlström-King; Jacques Couture; C Lamoureux; T Vaillancourt; Gabriel L Plaa
Dose-dependent cytotoxicity of chlorinated hydrocarbons in isolated rat hepatocytes.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;14(4):833-41.
1990: Serge Dionne; P Russo; B Tuch-Weber; Gabriel L Plaa; Ibrahim M Yousef
The role of acinar zone 3 hepatocytes in bile formation: influence of bromobenzene treatment on bile formation in the rat.
Liver 1990;10(2):85-93.
1990: L A Hewitt; C Palmason; S Masson; Gabriel L Plaa
Evidence for the involvement of organelles in the mechanism of ketone-potentiated chloroform-induced hepatotoxicity.
Liver 1990;10(1):35-48.
1989: Robert Tardif; Jules Brodeur; Gabriel L Plaa
Simultaneous high-performance liquid chromatographic analysis of hippuric acid and ortho-, meta-, and para-methylhippuric acids in urine.
Journal of analytical toxicology 1989;13(6):313-6.
1989: A B Kobusch; Gabriel L Plaa; Patrick Du Souich
Effects of acetone and methyl n-butyl ketone on hepatic mixed-function oxidase.
Biochemical pharmacology 1989;38(20):3461-7.
1989: L Dahlström-King; Gabriel L Plaa
Effect of inhibition of protein synthesis on cholestasis induced by taurolithocholate, lithocholate, and a manganese-bilirubin combination in the rat.
Biochemical pharmacology 1989;38(15):2543-9.
1989: J Cunningham; M Sharkawi; Gabriel L Plaa
Pharmacological and metabolic interactions between ethanol and methyl n-butyl ketone, methyl isobutyl ketone, methyl ethyl ketone, or acetone in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1989;13(1):102-9.
1988: P Ayotte; Gabriel L Plaa
Biliary excretion in Sprague-Dawley and Gunn rats during manganese-bilirubin-induced cholestasis.
Hepatology (Baltimore, Md.) 1988;8(5):1069-78.
1988: D Pilon; Jules Brodeur; Gabriel L Plaa
Potentiation of CCl4-induced liver injury by ketonic and ketogenic compounds: role of the CCl4 dose.
Toxicology and applied pharmacology 1988;94(2):183-90.
1988: Gabriel L Plaa
Experimental evaluation of haloalkanes and liver injury.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1988;10(4):563-70.
1988: Michel Charbonneau; F Perreault; E Greselin; Jules Brodeur; Gabriel L Plaa
Assessment of the minimal effective dose of acetone for potentiation of the hepatotoxicity induced by trichloroethylene-carbon tetrachloride mixtures.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1988;10(3):431-8.
1988: M Vézina; Gabriel L Plaa
Methyl isobutyl ketone metabolites and potentiation of the cholestasis induced in rats by a manganese-bilirubin combination or manganese alone.
Toxicology and applied pharmacology 1988;92(3):419-27.
1987: M Vézina; Gabriel L Plaa
Potentiation by methyl isobutyl ketone of the cholestasis induced in rats by a manganese-bilirubin combination or manganese alone.
Toxicology and applied pharmacology 1987;91(3):477-83.
1987: L A Hewitt; C Valiquette; Gabriel L Plaa
The role of biotransformation-detoxication in acetone-, 2-butanone-, and 2-hexanone-potentiated chloroform-induced hepatotoxicity.
Canadian journal of physiology and pharmacology 1987;65(11):2313-8.
1987: Gabriel L Plaa; G Caillé; M Vézina; M Iijima; M G Côté
Chloroform interaction with chlordecone and mirex: correlation between biochemical and histological indices of toxicity and quantitative tissue levels.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1987;9(2):198-207.
1987: P Ayotte; D Pilon; Gabriel L Plaa
Failure of phenobarbital or butanediol pretreatment to potentiate tienilic acid hepatotoxicity in vivo in the rat.
Archives internationales de pharmacodynamie et de thérapie 1987;286(1):49-57.
1986: D Pilon; Jules Brodeur; Gabriel L Plaa
1,3-Butanediol-induced increases in ketone bodies and potentiation of CCl4 hepatotoxicity.
Toxicology 1986;40(2):165-80.
1986: D Pilon; M Charbonneau; Jules Brodeur; Gabriel L Plaa
Metabolites and ketone body production following methyl n-butyl ketone exposure as possible indices of MnBK potentiation of carbon tetrachloride hepatotoxicity.
Toxicology and applied pharmacology 1986;85(1):49-59.
1986: P Ayotte; Gabriel L Plaa
Modification of biliary tree permeability in rats treated with a manganese-bilirubin combination.
Toxicology and applied pharmacology 1986;84(2):295-303.
1986: L A Hewitt; P Ayotte; Gabriel L Plaa
Modifications in rat hepatobiliary function following treatment with acetone, 2-butanone, 2-hexanone, mirex, or chlordecone and subsequently exposed to chloroform.
Toxicology and applied pharmacology 1986;83(3):465-73.
1986: L A Hewitt; G Caillé; Gabriel L Plaa
Temporal relationships between biotransformation, detoxication, and chlordecone potentiation of chloroform-induced hepatotoxicity.
Canadian journal of physiology and pharmacology 1986;64(4):477-82.
1985: P Ayotte; Gabriel L Plaa
Hepatic subcellular distribution of manganese in manganese and manganese-bilirubin induced cholestasis.
Biochemical pharmacology 1985;34(21):3857-65.
1985: Gabriel L Plaa; P Ayotte
Taurolithocholate-induced intrahepatic cholestasis: potentiation by methyl isobutyl ketone and methyl n-butyl ketone in rats.
Toxicology and applied pharmacology 1985;80(2):228-34.
1983: L A Hewitt; W R Hewitt; Gabriel L Plaa
Fractional hepatic localization of 14CHCl3 in mice and rats treated with chlordecone or mirex.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1983;3(6):489-95.
1982: W R Hewitt; H Miyajima; M G Côté; L A Hewitt; D J Cianflone; Gabriel L Plaa
Dose-response relationships in 1,3-butanediol-induced potentiation of carbon tetrachloride toxicity.
Toxicology and applied pharmacology 1982;64(3):529-40.
1980: W R Hewitt; H Miyajima; M G Côté; Gabriel L Plaa
Modification of haloalkane-induced hepatotoxicity by exogenous ketones and metabolic ketosis.
Federation proceedings 1980;39(13):3118-23.
1980: W R Hewitt; H Miyajima; M G Côté; Gabriel L Plaa
Acute alteration of chloroform-induced hepato- and nephrotoxicity by n-hexane, methyl n-butyl ketone, and 2,5-hexanedione.
Toxicology and applied pharmacology 1980;53(2):230-48.
1980: D J Cianflone; W R Hewitt; D C Villeneuve; Gabriel L Plaa
Role of biotransformation in the alterations of chloroform hepatotoxicity produced by Kepone and mirex.
Toxicology and applied pharmacology 1980;53(1):140-9.