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Kevin Plaxco

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Protein Folding

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Publications

TOP 3
Xia Fan; Zuo Xiaolei; Yang Renqiang; White Ryan J; Xiao Yi; Kang Di; Gong Xiong; Lubin Arica A; Vallée-Bélisle Alexis; Yuen Jonathan D; Hsu Ben Y B; Plaxco Kevin W
Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates.
Xia Fan; Zuo Xiaolei; Yang Renqiang; Xiao Yi; Kang Di; Vallée-Bélisle Alexis; Gong Xiong; Yuen Jonathan D; Hsu Ben B Y; Heeger Alan J; Plaxco Kevin W
Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes.
Lubin Arica A; Plaxco Kevin W
Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures.

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All Publications

2010: Xia Fan; Zuo Xiaolei; Yang Renqiang; White Ryan J; Xiao Yi; Kang Di; Gong Xiong; Lubin Arica A; Vallée-Bélisle Alexis; Yuen Jonathan D; Hsu Ben Y B; Plaxco Kevin W
Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates.
Journal of the American Chemical Society 2010;132(25):8557-9.
2010: Xia Fan; Zuo Xiaolei; Yang Renqiang; Xiao Yi; Kang Di; Vallée-Bélisle Alexis; Gong Xiong; Yuen Jonathan D; Hsu Ben B Y; Heeger Alan J; Plaxco Kevin W
Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(24):10837-41.
2010: Lubin Arica A; Plaxco Kevin W
Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures.
Accounts of chemical research 2010;43(4):496-505.
2010: Ricci Francesco; Adornetto Gianluca; Moscone Danila; Plaxco Kevin W; Palleschi Giuseppe
Quantitative, reagentless, single-step electrochemical detection of anti-DNA antibodies directly in blood serum.
Chemical communications (Cambridge, England) 2010;46(10):1742-4.
2010: Wickersham Charles E; Cash Kevin J; Pfeil Shawn H; Bruck Irina; Kaplan Daniel L; Plaxco Kevin W; Lipman Everett A
Tracking a molecular motor with a nanoscale optical encoder.
Nano letters 2010;10(3):1022-7.
2010: White Ryan J; Rowe Aaron A; Plaxco Kevin W
Re-engineering aptamers to support reagentless, self-reporting electrochemical sensors.
The Analyst 2010;135(3):589-94.
2010: Zuo Xiaolei; Xia Fan; Xiao Yi; Plaxco Kevin W
Sensitive and selective amplified fluorescence DNA detection based on exonuclease III-aided target recycling.
Journal of the American Chemical Society 2010;132(6):1816-8.
2010: Xia Fan; Zuo Xiaolei; Yang Renqiang; Xiao Yi; Kang Di; Vallée-Bélisle Alexis; Gong Xiong; Heeger Alan J; Plaxco Kevin W
On the binding of cationic, water-soluble conjugated polymers to DNA: electrostatic and hydrophobic interactions.
Journal of the American Chemical Society 2010;132(4):1252-4.
2010: White Ryan J; Plaxco Kevin W
Exploiting binding-induced changes in probe flexibility for the optimization of electrochemical biosensors.
Analytical chemistry 2010;82(1):73-6.
2009: Cash Kevin J; Ricci Francesco; Plaxco Kevin W
A general electrochemical method for label-free screening of protein-small molecule interactions.
Chemical communications (Cambridge, England) 2009;(41):6222-4.
2009: Kang Di; Zuo Xiaolei; Yang Renqiang; Xia Fan; Plaxco Kevin W; White Ryan J
Comparing the properties of electrochemical-based DNA sensors employing different redox tags.
Analytical chemistry 2009;81(21):9109-13.
2009: Kohn Jonathan E; Gillespie Blake; Plaxco Kevin W
Non-sequence-specific interactions can account for the compaction of proteins unfolded under "native" conditions.
Journal of molecular biology 2009;394(2):343-50.
2009: Xiao Yi; Lou Xinhui; Uzawa Takanori; Plakos Kory J I; Plaxco Kevin W; Soh H Tom
An electrochemical sensor for single nucleotide polymorphism detection in serum based on a triple-stem DNA probe.
Journal of the American Chemical Society 2009;131(42):15311-6.
2009: Cheng Ryan R; Uzawa Takanori; Plaxco Kevin W; Makarov Dmitrii E
The rate of intramolecular loop formation in DNA and polypeptides: the absence of the diffusion-controlled limit and fractional power-law viscosity dependence.
The journal of physical chemistry. B 2009;113(42):14026-34.
2009: Ricci Francesco; Zari Nadia; Caprio Felice; Recine Simona; Amine Aziz; Moscone Danila; Palleschi Giuseppe; Plaxco Kevin W
Surface chemistry effects on the performance of an electrochemical DNA sensor.
Bioelectrochemistry (Amsterdam, Netherlands) 2009;76(1-2):208-13.
2009: Vallée-Bélisle Alexis; Ricci Francesco; Plaxco Kevin W
Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13802-7.
2009: Makarov Dmitrii E; Plaxco Kevin W
Measuring distances within unfolded biopolymers using fluorescence resonance energy transfer: The effect of polymer chain dynamics on the observed fluorescence resonance energy transfer efficiency.
The Journal of chemical physics 2009;131(8):085105.
2009: Uzawa Takanori; Cheng Ryan R; Cash Kevin J; Makarov Dmitrii E; Plaxco Kevin W
The length and viscosity dependence of end-to-end collision rates in single-stranded DNA.
Biophysical journal 2009;97(1):205-10.
2009: Cash Kevin J; Ricci Francesco; Plaxco Kevin W
An electrochemical sensor for the detection of protein-small molecule interactions directly in serum and other complex matrices.
Journal of the American Chemical Society 2009;131(20):6955-7.
2009: Zuo Xiaolei; Xiao Yi; Plaxco Kevin W
High specificity, electrochemical sandwich assays based on single aptamer sequences and suitable for the direct detection of small-molecule targets in blood and other complex matrices.
Journal of the American Chemical Society 2009;131(20):6944-5.
2009: Swensen James S; Xiao Yi; Ferguson Brian S; Lubin Arica A; Lai Rebecca Y; Heeger Alan J; Plaxco Kevin W; Soh H Tom
Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor.
Journal of the American Chemical Society 2009;131(12):4262-6.
2009: Lubin Arica A; Hunt Brook Vander Stoep; White Ryan J; Plaxco Kevin W
Effects of probe length, probe geometry, and redox-tag placement on the performance of the electrochemical E-DNA sensor.
Analytical chemistry 2009;81(6):2150-8.
2009: Ricci Francesco; Bonham Andrew J; Mason Aaron C; Reich Norbert O; Plaxco Kevin W
Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins.
Analytical chemistry 2009;81(4):1608-14.
2009: Phares Noelle; White Ryan J; Plaxco Kevin W
Improving the stability and sensing of electrochemical biosensors by employing trithiol-anchoring groups in a six-carbon self-assembled monolayer.
Analytical chemistry 2009;81(3):1095-100.
2009: Cash Kevin J; Heeger Alan J; Plaxco Kevin W; Xiao Yi
Optimization of a reusable, DNA pseudoknot-based electrochemical sensor for sequence-specific DNA detection in blood serum.
Analytical chemistry 2009;81(2):656-61.
2009: Plaxco Kevin W; Gross Michael
Protein complexes: the evolution of symmetry.
Current biology : CB 2009;19(1):R25-6.
2009: Xiao Yi; Plakos Kory J I; Lou Xinhui; White Ryan J; Qian Jiangrong; Plaxco Kevin W; Soh H Tom
Fluorescence detection of single-nucleotide polymorphisms with a single, self-complementary, triple-stem DNA probe.
Angewandte Chemie (International ed. in English) 2009;48(24):4354-8.
2009: Oh Kenneth J; Cash Kevin J; Plaxco Kevin W
Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(10):2244-51.
2008: White Ryan J; Phares Noelle; Lubin Arica A; Xiao Yi; Plaxco Kevin W
Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistry.
Langmuir : the ACS journal of surfaces and colloids 2008;24(18):10513-8.
2008: Pavlovic Elizabeth; Lai Rebecca Y; Wu Ting Ting; Ferguson Brian S; Sun Ren; Plaxco Kevin W; Soh H T
Microfluidic device architecture for electrochemical patterning and detection of multiple DNA sequences.
Langmuir : the ACS journal of surfaces and colloids 2008;24(3):1102-7.
2007: Oh Kenneth J; Cash Kevin J; Lubin Arica A; Plaxco Kevin W
Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons.
Chemical communications (Cambridge, England) 2007;(46):4869-71.
2007: Xiao Yi; Qu Xiaogang; Plaxco Kevin W; Heeger Alan J
Label-free electrochemical detection of DNA in blood serum via target-induced resolution of an electrode-bound DNA pseudoknot.
Journal of the American Chemical Society 2007;129(39):11896-7.
2007: Ricci Francesco; Lai Rebecca Y; Plaxco Kevin W
Linear, redox modified DNA probes as electrochemical DNA sensors.
Chemical communications (Cambridge, England) 2007;(36):3768-70.
2007: Wang Zhisong; Plaxco Kevin W; Makarov Dmitrii E
Influence of local and residual structures on the scaling behavior and dimensions of unfolded proteins.
Biopolymers 2007;86(4):321-8.
2007: Ricci Francesco; Lai Rebecca Y; Heeger Alan J; Plaxco Kevin W; Sumner James J
Effect of molecular crowding on the response of an electrochemical DNA sensor.
Langmuir : the ACS journal of surfaces and colloids 2007;23(12):6827-34.
2007: Oh Kenneth J; Cash Kevin J; Hugenberg Verena; Plaxco Kevin W
Peptide beacons: a new design for polypeptide-based optical biosensors.
Bioconjugate chemistry 2007;18(3):607-9.
2007: Werner James H; McCarney Evan R; Keller Richard A; Plaxco Kevin W; Goodwin Peter M
Increasing the resolution of single pair fluorescence resonance energy transfer measurements in solution via molecular cytometry.
Analytical chemistry 2007;79(9):3509-13.
2007: Xiao Yi; Rowe Aaron A; Plaxco Kevin W
Electrochemical detection of parts-per-billion lead via an electrode-bound DNAzyme assembly.
Journal of the American Chemical Society 2007;129(2):262-3.
2007: Lai Rebecca Y; Plaxco Kevin W; Heeger Alan J
Aptamer-based electrochemical detection of picomolar platelet-derived growth factor directly in blood serum.
Analytical chemistry 2007;79(1):229-33.
2007: Xiao Yi; Lai Rebecca Y; Plaxco Kevin W
Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing.
Nature protocols 2007;2(11):2875-80.
2006: Lai Rebecca Y; Seferos Dwight S; Heeger Alan J; Bazan Guillermo C; Plaxco Kevin W
Comparison of the signaling and stability of electrochemical DNA sensors fabricated from 6- or 11-carbon self-assembled monolayers.
Langmuir : the ACS journal of surfaces and colloids 2006;22(25):10796-800.
2006: Xu Jing; Plaxco Kevin W; Allen S James
Collective dynamics of lysozyme in water: terahertz absorption spectroscopy and comparison with theory.
The journal of physical chemistry. B 2006;110(47):24255-9.
2006: Xiao Yi; Lubin Arica A; Baker Brian R; Plaxco Kevin W; Heeger Alan J
Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16677-80.
2006: Oh Kenneth J; Cash Kevin J; Plaxco Kevin W
Excimer-based peptide beacons: a convenient experimental approach for monitoring polypeptide-protein and polypeptide-oligonucleotide interactions.
Journal of the American Chemical Society 2006;128(43):14018-9.
2006: Ruczinski Ingo; Sosnick Tobin R; Plaxco Kevin W
Methods for the accurate estimation of confidence intervals on protein folding phi-values.
Protein science : a publication of the Protein Society 2006;15(10):2257-64.
2006: Lubin Arica A; Lai Rebecca Y; Baker Brian R; Heeger Alan J; Plaxco Kevin W
Sequence-specific, electronic detection of oligonucleotides in blood, soil, and foodstuffs with the reagentless, reusable E-DNA sensor.
Analytical chemistry 2006;78(16):5671-7.
2006: Faísca Patrícia F N; Plaxco Kevin W
Cooperativity and the origins of rapid, single-exponential kinetics in protein folding.
Protein science : a publication of the Protein Society 2006;15(7):1608-18.
2006: Xu Jing; Plaxco Kevin W; Allen S James
Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy.
Protein science : a publication of the Protein Society 2006;15(5):1175-81.
2006: Lai Rebecca Y; Lagally Eric T; Lee Sang-Ho; Soh H T; Plaxco Kevin W; Heeger Alan J
Rapid, sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4017-21.
2006: Baker Brian R; Lai Rebecca Y; Wood McCall S; Doctor Elaine H; Heeger Alan J; Plaxco Kevin W
An electronic, aptamer-based small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids.
Journal of the American Chemical Society 2006;128(10):3138-9.
2006: de los Rios Miguel A; Muralidhara B K; Wildes David; Sosnick Tobin R; Marqusee Susan; Wittung-Stafshede Pernilla; Plaxco Kevin W; Ruczinski Ingo
On the precision of experimentally determined protein folding rates and phi-values.
Protein science : a publication of the Protein Society 2006;15(3):553-63.
2006: Lai Rebecca Y; Lee Sang-ho; Soh H T; Plaxco Kevin W; Heeger Alan J
Differential labeling of closely spaced biosensor electrodes via electrochemical lithography.
Langmuir : the ACS journal of surfaces and colloids 2006;22(4):1932-6.
2006: Xu Jing; Plaxco Kevin W; Allen S James
Absorption spectra of liquid water and aqueous buffers between 0.3 and 3.72 THz.
The Journal of chemical physics 2006;124(3):036101.
2005: Xiao Yi; Piorek Brian D; Plaxco Kevin W; Heeger Alan J
A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement.
Journal of the American Chemical Society 2005;127(51):17990-1.
2005: de los Rios Miguel A; Daneshi Mona; Plaxco Kevin W
Experimental investigation of the frequency and substitution dependence of negative phi-values in two-state proteins.
Biochemistry 2005;44(36):12160-7.
2005: McCarney Evan R; Werner James H; Bernstein Summer L; Ruczinski Ingo; Makarov Dmitrii E; Goodwin Peter M; Plaxco Kevin W
Site-specific dimensions across a highly denatured protein; a single molecule study.
Journal of molecular biology 2005;352(3):672-82.
2005: Kohn Jonathan E; Plaxco Kevin W
Engineering a signal transduction mechanism for protein-based biosensors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10841-5.
2005: Xiao Yi; Lubin Arica A; Heeger Alan J; Plaxco Kevin W
Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor.
Angewandte Chemie (International ed. in English) 2005;44(34):5456-9.
2005: McCarney Evan R; Kohn Jonathan E; Plaxco Kevin W
Is there or isn't there? The case for (and against) residual structure in chemically denatured proteins.
Critical reviews in biochemistry and molecular biology 2005;40(4):181-9.
2005: Fan Chunhai; Plaxco Kevin W; Heeger Alan J
Biosensors based on binding-modulated donor-acceptor distances.
Trends in biotechnology 2005;23(4):186-92.
2005: Raleigh Daniel P; Plaxco Kevin W
The protein folding transition state: what are Phi-values really telling us?
Protein and peptide letters 2005;12(2):117-22.
2005: de Los Rios Miguel A; Plaxco Kevin W
Apparent Debye-Huckel electrostatic effects in the folding of a simple, single domain protein.
Biochemistry 2005;44(4):1243-50.
2004: Kohn Jonathan E; Millett Ian S; Jacob Jaby; Zagrovic Bojan; Dillon Thomas M; Cingel Nikolina; Dothager Robin S; Seifert Soenke; Thiyagarajan P; Sosnick Tobin R; Hasan M Zahid; Pande Vijay S; Ruczinski Ingo; Doniach Sebastian; Plaxco Kevin W
Random-coil behavior and the dimensions of chemically unfolded proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12491-6.
2004: Gillespie Blake; Plaxco Kevin W
Using protein folding rates to test protein folding theories.
Annual review of biochemistry 2004;73():837-59.
2003: Ivankov Dmitry N; Garbuzynskiy Sergiy O; Alm Eric; Plaxco Kevin W; Baker David; Finkelstein Alexei V
Contact order revisited: influence of protein size on the folding rate.
Protein science : a publication of the Protein Society 2003;12(9):2057-62.
2003: Fan Chunhai; Plaxco Kevin W; Heeger Alan J
Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9134-7.
2003: Gillespie Blake; Vu Dung M; Shah Premal S; Marshall Shannon A; Dyer R Brian; Mayo Stephen L; Plaxco Kevin W
NMR and temperature-jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit selection for kinetics.
Journal of molecular biology 2003;330(4):813-9.
2003: Calloni Giulia; Taddei Niccolò; Plaxco Kevin W; Ramponi Giampietro; Stefani Massimo; Chiti Fabrizio
Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding.
Journal of molecular biology 2003;330(3):577-91.
2003: Fan Chunhai; Wang Shu; Hong Janice W; Bazan Guillermo C; Plaxco Kevin W; Heeger Alan J
Beyond superquenching: hyper-efficient energy transfer from conjugated polymers to gold nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6297-301.
2003: Jewett Andrew I; Pande Vijay S; Plaxco Kevin W
Cooperativity, smooth energy landscapes and the origins of topology-dependent protein folding rates.
Journal of molecular biology 2003;326(1):247-53.
2003: Makarov Dmitrii E; Plaxco Kevin W
The topomer search model: A simple, quantitative theory of two-state protein folding kinetics.
Protein science : a publication of the Protein Society 2003;12(1):17-26.
2003: Xu Jing; Ramian Gerald J; Galan Jhenny F; Savvidis Pavlos G; Scopatz Anthony Michael; Birge Robert R; Allen S James; Plaxco Kevin W
Terahertz circular dichroism spectroscopy: a potential approach to the in situ detection of life's metabolic and genetic machinery.
Astrobiology 2003;3(3):489-504.
2002: Thompson James B; Hansma Helen G; Hansma Paul K; Plaxco Kevin W
The backbone conformational entropy of protein folding: experimental measures from atomic force microscopy.
Journal of molecular biology 2002;322(3):645-52.
2002: Fan Chunhai; Plaxco Kevin W; Heeger Alan J
High-efficiency fluorescence quenching of conjugated polymers by proteins.
Journal of the American Chemical Society 2002;124(20):5642-3.
2002: Makarov Dmitrii E; Keller Craig A; Plaxco Kevin W; Metiu Horia
How the folding rate constant of simple, single-domain proteins depends on the number of native contacts.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3535-9.
2002: Larson Stefan M; Ruczinski Ingo; Davidson Alan R; Baker David; Plaxco Kevin W
Residues participating in the protein folding nucleus do not exhibit preferential evolutionary conservation.
Journal of molecular biology 2002;316(2):225-33.
2002: Millet Ian S; Townsley Lara E; Chiti Fabrizio; Doniach Sebastian; Plaxco Kevin W
Equilibrium collapse and the kinetic 'foldability' of proteins.
Biochemistry 2002;41(1):321-5.
2002: Millett Ian S; Doniach Sebastian; Plaxco Kevin W
Toward a taxonomy of the denatured state: small angle scattering studies of unfolded proteins.
Advances in protein chemistry 2002;62():241-62.
2000: Gillespie B; Plaxco K W
Nonglassy kinetics in the folding of a simple single-domain protein.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12014-9.
2000: Plaxco K W; Simons K T; Ruczinski I; Baker D
Topology, stability, sequence, and length: defining the determinants of two-state protein folding kinetics.
Biochemistry 2000;39(37):11177-83.
2000: Plaxco K W; Larson S; Ruczinski I; Riddle D S; Thayer E C; Buchwitz B; Davidson A R; Baker D
Evolutionary conservation in protein folding kinetics.
Journal of molecular biology 2000;298(2):303-12.
1999: Plaxco K W; Millett I S; Segel D J; Doniach S; Baker D
Chain collapse can occur concomitantly with the rate-limiting step in protein folding.
Nature structural biology 1999;6(6):554-6.
1998: Plaxco K W; Baker D
Limited internal friction in the rate-limiting step of a two-state protein folding reaction.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13591-6.
1998: Plaxco K W; Simons K T; Baker D
Contact order, transition state placement and the refolding rates of single domain proteins.
Journal of molecular biology 1998;277(4):985-94.
1998: Plaxco K W; Riddle D S; Grantcharova V; Baker D
Simplified proteins: minimalist solutions to the 'protein folding problem'.
Current opinion in structural biology 1998;8(1):80-5.

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