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Sven Pleger

Research Profile

Chemicals & Drugs

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TOP 3
Philip Raake; Julia Reinkober; Stefanie Schinkel; Philipp Schlegel; Sven T Pleger; Jens Barthelmes; Uwe Haberkorn; Hugo A Katus; Walter J Koch; Jan Ksienzyk; Walter Mier; Patrick Most; Oliver J Müller
AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model.
Sven T Pleger; H A Katus; R Bekeredjian
[Severe mitral valve regurgitation in terminal heart failure: news beyond guidelines].
Hugo A Katus; Sven T Pleger
[Progress in subdisciplines: intervention or operation?].

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All Publications

2013: Philip Raake; Julia Reinkober; Stefanie Schinkel; Philipp Schlegel; Sven T Pleger; Jens Barthelmes; Uwe Haberkorn; Hugo A Katus; Walter J Koch; Jan Ksienzyk; Walter Mier; Patrick Most; Oliver J Müller
AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model.
European heart journal 2013;34(19):1437-47.
2013: Sven T Pleger; H A Katus; R Bekeredjian
[Severe mitral valve regurgitation in terminal heart failure: news beyond guidelines].
Deutsche medizinische Wochenschrift (1946) 2013;138(12):600-2.
2013: Hugo A Katus; Sven T Pleger
[Progress in subdisciplines: intervention or operation?].
Herz 2013;38(2):111.
2013: R Bekeredjian; Sven T Pleger; E Chorianopoulos
[High-risk patients with aortic valve stenosis. Interventional therapy].
Herz 2013;38(2):118-25.
2013: Sven T Pleger; Emmanuel Chorianopoulos; Hugo A Katus; Ulrike Krumsdorf; Raffi Bekeredjian
Percutaneous edge-to-edge repair of mitral regurgitation as a bail-out strategy in critically ill patients.
The Journal of invasive cardiology 2013;25(2):69-72.
2013: Patrick Most; Sven T Pleger; Giuseppe Rengo; Julia Ritterhoff; David Rohde; Norbert Weiss; Cornelius J Busch; Chelain Goodman; Julian Heissenberg; Hugo A Katus; Walter J Koch; Felix Laube; Carolin Lerchenmüller; Adrian Mahlmann; Karsten Peppel
S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation.
Circulation research 2013;112(1):66-78.
2013: Patrick Most; Philip Raake; Christophe Weber; Hugo A Katus; Sven T Pleger
S100A1 gene therapy in small and large animals.
Methods in molecular biology (Clifton, N.J.) 2013;963():407-20.
2012: Ulrike Krumsdorf; Sven T Pleger; Emmanuel Chorianopoulos; Klaus Kallenbach; Matthias Karck; Hugo A Katus; Raffi Bekeredjian
C-reactive protein kinetics and its prognostic value after transfemoral aortic valve implantation.
The Journal of invasive cardiology 2012;24(6):282-6.
2012: J Reinkober; H Tscheschner; Hugo A Katus; Walter J Koch; Patrick Most; Sven T Pleger; Philip Raake
Targeting GRK2 by gene therapy for heart failure: benefits above β-blockade.
Gene therapy 2012;19(6):686-93.
2012: Emmanuel Chorianopoulos; Hugo A Katus; Ulrike Krumsdorf; Sven T Pleger; Raffi Bekeredjian
Incidence of late occurring bradyarrhythmias after TAVI with the self-expanding CoreValve(®) aortic bioprosthesis.
Clinical research in cardiology : official journal of the German Cardiac Society 2012;101(5):349-55.
2012: Emmanuel Chorianopoulos; Hugo A Katus; Ulrike Krumsdorf; Sven T Pleger; Raffi Bekeredjian
Improved procedural results after CoreValve implantation with the new AccuTrak delivery system.
Journal of interventional cardiology 2012;25(2):174-9.
2011: Sven T Pleger; Wolfgang Rottbauer; Marius Schulz-Schönhagen; Emmanuel Chorianopoulos; Hugo A Katus; Ulrike Krumsdorf; Derliz Mereles; Raffi Bekeredjian
Acute safety and 30-day outcome after percutaneous edge-to-edge repair of mitral regurgitation in very high-risk patients.
The American journal of cardiology 2011;108(10):1478-82.
2011: Henriette Brinks; Thierry Carrel; Andrea D Eckhart; Nicole Herzog; Hugo A Katus; Walter J Koch; Carolin Lerchenmüller; Paul J Mather; Sven T Pleger; Gang Qiu; Joseph Rabinowitz; David Rohde; Arjang Ruhparwar; Scott Silvestry; Mirko Voelkers; Patrick Most
S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes.
Journal of the American College of Cardiology 2011;58(9):966-73.
2011: Sven T Pleger; Gang Qiu; Philip Raake; Stefanie Schinkel; Changguang Shan; Christophe Weber; Oliver J Müller; Raffi Bekeredjian; Peter Boekstegers; Rabea Hinkel; Hugo A Katus; Walter J Koch; Jan Ksienzyk; Barbara Leuchs; Jochen Ludwig; Patrick Most
Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model.
Science translational medicine 2011;3(92):92ra64.
2010: Christian Volz; Cathrin Seidel; Danai Laohachewin; Ziya Kaya; Oliver J Müller; Sven T Pleger; Felix Lasitschka; Marco E Bianchi; Andrew Remppis; Angelika Bierhaus; Hugo A Katus; Martin Andrassy
HMGB1: the missing link between diabetes mellitus and heart failure.
Basic research in cardiology 2010;105(6):805-20.
2010: Vasileios Askoxylakis; Christian Thieke; Sven T Pleger; Patrick Most; Judith Tanner; Katja Lindel; Hugo A Katus; Jürgen Debus; Marc Bischof
Long-term survival of cancer patients compared to heart failure and stroke: a systematic review.
BMC cancer 2010;10():105.
2009: Carolin Kraus; David Rohde; Christian Weidenhammer; Gang Qiu; Sven T Pleger; Mirko Voelkers; Melanie Boerries; Andrew Remppis; Hugo A Katus; Patrick Most
S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy.
Journal of molecular and cellular cardiology 2009;47(4):445-55.
2008: Martin Andrassy; Christian Volz; John C Igwe; Benjamin Funke; Sebastian N Eichberger; Ziya Kaya; Sebastian J Buss; Frank Autschbach; Sven T Pleger; Ivan K Lukic; Florian Bea; Stefan E Hardt; Per M Humpert; Marco E Bianchi; Heimo Mairbäurl; Peter P Nawroth; Andrew Remppis; Hugo A Katus; Angelika Bierhaus
High-mobility group box-1 in ischemia-reperfusion injury of the heart.
Circulation 2008;117(25):3216-26.
2008: Sven T Pleger; David M Harris; Changguang Shan; Leif E Vinge; J Kurt Chuprun; Brett Berzins; Wiebke Pleger; Charles Druckman; Mirko Völkers; Jörg Heierhorst; Erik Øie; Andrew Remppis; Hugo A Katus; Rosario Scalia; Andrea D Eckhart; Walter J Koch; Patrick Most
Endothelial S100A1 modulates vascular function via nitric oxide.
Circulation research 2008;102(7):786-94.
2007: Sven T Pleger; Patrick Most; Walter J Koch
Recent findings into the potential of gene therapy to reverse heart failure.
Expert opinion on biological therapy 2007;7(12):1781-4.
2007: Patrick Most; Andrew Remppis; Sven T Pleger; Hugo A Katus; Walter J Koch
S100A1: a novel inotropic regulator of cardiac performance. Transition from molecular physiology to pathophysiological relevance.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(2):R568-77.
2007: Sven T Pleger; Patrick Most; Hugo A Katus
S100 proteins: a missing piece in the puzzle of heart failure?
Cardiovascular research 2007;75(1):1-2.
2007: Sven T Pleger; Matthieu Boucher; Patrick Most; Walter J Koch
Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapy.
Journal of cardiac failure 2007;13(5):401-14.
2007: Sven T Pleger; Patrick Most; Matthieu Boucher; Stephen Soltys; J Kurt Chuprun; Wiebke Pleger; Erhe Gao; Abhijit Dasgupta; Giuseppe Rengo; Andrew Remppis; Hugo A Katus; Andrea D Eckhart; Joseph E Rabinowitz; Walter J Koch
Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.
Circulation 2007;115(19):2506-15.
2006: Sven T Pleger; Patrick Most; Beatrix Heidt; M Voelkers; J A Hata; Hugo A Katus; Andrew Remppis; Walter J Koch
S100A1 gene transfer in myocardium.
European journal of medical research 2006;11(10):418-22.
2006: Patrick Most; Hanna Seifert; Erhe Gao; Hajime Funakoshi; Mirko Völkers; Jörg Heierhorst; Andrew Remppis; Sven T Pleger; Brent R DeGeorge; Andrea D Eckhart; Arthur M Feldman; Walter J Koch
Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.
Circulation 2006;114(12):1258-68.
2006: Michael Hambleton; Harvey Hahn; Sven T Pleger; Matthew C Kuhn; Raisa Klevitsky; Andrew N Carr; Thomas F Kimball; Timothy E Hewett; Gerald W Dorn; Walter J Koch; Jeffery D Molkentin
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.
Circulation 2006;114(6):574-82.
2006: Sven T Pleger; Walter J Koch
The yin and yang of increased beta-adrenergic signaling: beta1-adrenergic genetic polymorphism and protection against acute myocardial ischemic injury.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1408-9.
2006: Oliver J Müller; Barbara Leuchs; Sven T Pleger; Dirk Grimm; Wolfgang M Franz; Hugo A Katus; Jürgen A Kleinschmidt
Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors.
Cardiovascular research 2006;70(1):70-8.
2005: Sven T Pleger; Andrew Remppis; Beatrix Heidt; Mirko Völkers; J Kurt Chuprun; Matthew Kuhn; Rui-Hai Zhou; Erhe Gao; Gabor Szabo; Dieter Weichenhan; Oliver J Müller; Andrea D Eckhart; Hugo A Katus; Walter J Koch; Patrick Most
S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1120-9.
2005: Sven T Pleger; Walter J Koch
Translational medicine in genetic familial diseases: from the autopsy room to the molecular bench and vice versa.
Human pathology 2005;36(7):708-9.
2004: Patrick Most; Sven T Pleger; Mirko Völkers; Beatrix Heidt; Melanie Boerries; Dieter Weichenhan; Eva Löffler; Paul Janssen; Andrea D Eckhart; Jeffrey Martini; Matthew L Williams; Hugo A Katus; Andrew Remppis; Walter J Koch
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.
The Journal of clinical investigation 2004;114(11):1550-63.
2004: Patrick Most; Carmen Eicher; Mirko Völkers; Sven T Pleger; Hugo A Katus
Hope for a broken heart?
Trends in biotechnology 2004;22(10):487-9.
2004: Andrew Remppis; Sven T Pleger; Patrick Most; Jan Lindenkamp; Philipp Ehlermann; Christopher Schweda; Eva Löffler; Dieter Weichenhan; Wolfram Zimmermann; Thomas Eschenhagen; Walter J Koch; Hugo A Katus
S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts.
The journal of gene medicine 2004;6(4):387-94.
2003: Patrick Most; Melanie Boerries; Carmen Eicher; Christopher Schweda; Philipp Ehlermann; Sven T Pleger; Eva Loeffler; Walter J Koch; Hugo A Katus; Cora-Ann Schoenenberger; Andrew Remppis
Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2).
The Journal of biological chemistry 2003;278(48):48404-12.
2003: Patrick Most; Andrew Remppis; Sven T Pleger; Eva Löffler; Philipp Ehlermann; Juliane Bernotat; Christiane Kleuss; Jörg Heierhorst; Patricia Ruiz; Henning Witt; Peter Karczewski; Lan Mao; Howard A Rockman; Sandra J Duncan; Hugo A Katus; Walter J Koch
Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
The Journal of biological chemistry 2003;278(36):33809-17.
2003: Patrick Most; Andrew Remppis; Cornelia Weber; Juliane Bernotat; Philipp Ehlermann; Sven T Pleger; Wolfgang G Kirsch; Martin Weber; Dietmar Uttenweiler; Godfrey L Smith; Hugo A Katus; Rainer H A Fink
The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers.
The Journal of biological chemistry 2003;278(29):26356-64.
2002: Andrew Remppis; Patrick Most; Eva Löffler; Philipp Ehlermann; Juliane Bernotat; Sven T Pleger; Melanie Börries; Michael Reppel; Joachim Fischer; Walter J Koch; Godfrey Smith; Hugo A Katus
The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes.
Basic research in cardiology 2002;97 Suppl 1():I56-62.
2001: Patrick Most; Juliane Bernotat; Philipp Ehlermann; Sven T Pleger; Michael Reppel; M Börries; F Niroomand; B Pieske; Paul Janssen; Thomas Eschenhagen; P Karczewski; Godfrey L Smith; Walter J Koch; Hugo A Katus; Andrew Remppis
S100A1: a regulator of myocardial contractility.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13889-94.