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Hidde Ploegh

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Jihee Kim; Eun-Hye Kwon; Hidde L Ploegh; Melanie M Brinkmann; Jiwon Huh; Misun Hwang; Myoung Ho Jang; Da-Jung Jung; You-Me Kim
Acidic Amino Acid Residues in the Juxtamembrane Region of the Nucleotide-Sensing TLRs Are Important for UNC93B1 Binding and Signaling.
Anjan K Saha; Nirit Mor-Vaknin; Amruta Mundade; Hidde L Ploegh; David M Rosmarin; Barbara S Adams; Zeina Al-Obaidi; Nicolas Chatain; Anja Deutzmann; Elisa Ferrando-May; Ferdinand Kappes; Maureen Legendre; David M Markovitz
Intercellular trafficking of the nuclear oncoprotein DEK.
Fikadu G Tafesse; Sumana Sanyal; Pentti Somerharju; Joseph Ashour; Carla P Guimaraes; Martin Hermansson; Hidde L Ploegh
Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins.

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2013: Jihee Kim; Eun-Hye Kwon; Hidde L Ploegh; Melanie M Brinkmann; Jiwon Huh; Misun Hwang; Myoung Ho Jang; Da-Jung Jung; You-Me Kim
Acidic Amino Acid Residues in the Juxtamembrane Region of the Nucleotide-Sensing TLRs Are Important for UNC93B1 Binding and Signaling.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(10):5287-95.
2013: Anjan K Saha; Nirit Mor-Vaknin; Amruta Mundade; Hidde L Ploegh; David M Rosmarin; Barbara S Adams; Zeina Al-Obaidi; Nicolas Chatain; Anja Deutzmann; Elisa Ferrando-May; Ferdinand Kappes; Maureen Legendre; David M Markovitz
Intercellular trafficking of the nuclear oncoprotein DEK.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):6847-52.
2013: Fikadu G Tafesse; Sumana Sanyal; Pentti Somerharju; Joseph Ashour; Carla P Guimaraes; Martin Hermansson; Hidde L Ploegh
Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6406-11.
2013: Gabriel L Hendricks; Evelyn A Kurt-Jones; Jing Li; Hidde L Ploegh; Zachary H Shriver; Karthik Viswanathan; Joseph Ashour; James C Comolli; Robert W Finberg; Deborah K Fygenson; Kim L Weirich; Jennifer P Wang
Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus.
The Journal of biological chemistry 2013;288(12):8061-73.
2013: Sharvan Sehrawat; Christian Schlieker; Manuel Fankhauser; Oktay Kirak; Paul-Albert Koenig; Hidde L Ploegh
A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation.
Blood 2013;121(7):1145-56.
2013: Jasper H L Claessen; Eric Spooner; Martin D Witte; Nicholas C Yoder; Angela Y Zhu; Hidde L Ploegh
Catch-and-release probes applied to semi-intact cells reveal ubiquitin-specific protease expression in Chlamydia trachomatis infection.
Chembiochem : a European journal of chemical biology 2013;14(3):343-52.
2013: Lee Kim Swee; M Inmaculada Barrasa; Carla P Guimaraes; Sharvan Sehrawat; Eric Spooner; Hidde L Ploegh
Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(4):1428-33.
2013: Ana M Avalos; Rudolf Jaenisch; You-Me Kim; Oktay Kirak; J Margit Oelkers; Matthias Ottinger; Marina C Pils; Hidde L Ploegh; Melanie M Brinkmann
Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(2):695-702.
2012: Stephanie K Dougan; Gijsbert M Grotenbreg; Eduardo Guillen; Chih-Chi Andrew Hu; Rudolf Jaenisch; Souichi Ogata; Hidde L Ploegh
IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13739-44.
2012: Martin D Witte; Nicholas C Yoder; Juan J Cragnolini; Stephanie K Dougan; Maximilian W Popp; Hidde L Ploegh
Preparation of unnatural N-to-N and C-to-C protein fusions.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(30):11993-8.
2012: Gaelen T Hess; Hidde L Ploegh; Maximilian W Popp; Eric Spooner; Mark A Allen; Angela M Belcher; Juan J Cragnolini; Stephanie K Dougan; Carla P Guimaraes
M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins.
Bioconjugate chemistry 2012;23(7):1478-87.
2012: Sumana Sanyal; Jasper H L Claessen; Hidde L Ploegh
A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells.
The Journal of biological chemistry 2012;287(28):23594-603.
2012: David M Rosmarin; Michael N Starnbach; Thijn R Brummelkamp; Jan E Carette; Andrew J Olive; Hidde L Ploegh
Attachment of Chlamydia trachomatis L2 to host cells requires sulfation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):10059-64.
2012: Sabrina M Lehmann; Jan Baumgart; Katja Derkow; Gina Eom; Eleonora Franzoni; Douglas Golenbock; Piet Habbel; Frank L Heppner; Michael Hinz; Roland Kälin; David Kaul; Christina Krüger; Duong Nguyen; Olaf Ninnemann; Robert Nitsch; Boyoun Park; Oliver Peters; Hidde L Ploegh; Karen Rosenberger; Agnieszka Rybak; Eckart Schott; Thorsten Trimbuch; Rüdiger Veh; FG Wulczyn; Seija Lehnardt
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
Nature neuroscience 2012;15(6):827-35.
2012: Karin Strijbis; Eric Spooner; Hidde L Ploegh
Protein ligation in living cells using sortase.
Traffic (Copenhagen, Denmark) 2012;13(6):780-9.
2012: Sharvan Sehrawat; J Pedro Simas; Gunes Bozkurt; Marisa K Isaacson; Rudolph Jaenisch; Oktay Kirak; Paul-Albert Koenig; Sofia Marques; Hidde L Ploegh
CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection.
Cell reports 2012;1(5):461-71.
2012: Clarissa C Lee; Ana M Avalos; Hidde L Ploegh
Accessory molecules for Toll-like receptors and their function.
Nature reviews. Immunology 2012;12(3):168-79.
2012: Irlanda Olvera-Gomez; Hidde L Ploegh; Liangchun Wang; Zhengguo Xiao; Carla P Guimaraes; Sara E Hamilton; Kristin A Hogquist; Stephen C Jameson
Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(6):2072-7.
2012: Arundhati Ray; Eric Spooner; Simon N Willis; Qian Wu; Hidde L Ploegh; Anthony A Amato; Elizabeth M Bradshaw; Daniel B DiCapua; Kevin J Felice; Jonathan M Goldstein; Ingrid E Lundberg; Richard J Nowak; Kevin C O'Connor
Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis.
PloS one 2012;7(10):e46709.
2012: Maximilian Wei-Lin Popp; Roos A Karssemeijer; Hidde L Ploegh
Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time.
PLoS pathogens 2012;8(3):e1002604.
2012: Annemarthe G van der Veen; Hidde L Ploegh
Ubiquitin-like proteins.
Annual review of biochemistry 2012;81():323-57.
2012: Cristina Maria Costantino; Hidde L Ploegh; Eric Spooner; David A Hafler
Class II MHC self-antigen presentation in human B and T lymphocytes.
PloS one 2012;7(1):e29805.
2011: Carla P Guimaraes; John Antos; Thijn R Brummelkamp; Jan E Carette; Maximilian W Popp; Eric Spooner; Malini Varadarajan; Hidde L Ploegh
Identification of host cell factors required for intoxication through use of modified cholera toxin.
The Journal of cell biology 2011;195(5):751-64.
2011: Melanie H Smith; Hidde L Ploegh; Jonathan S Weissman
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum.
Science (New York, N.Y.) 2011;334(6059):1086-90.
2011: Elizabeth J Klemm; Eric Spooner; Hidde L Ploegh
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.
The Journal of biological chemistry 2011;286(43):37602-14.
2011: Ana M Avalos; Hidde L Ploegh
Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9.
European journal of immunology 2011;41(10):2820-7.
2011: Mona Mashayekhi; Ildiko R Dunay; Eva M Frickel; Romina S Goldszmid; Asis Khan; Theresa L Murphy; Hidde L Ploegh; Michelle Sandau; Alan Sher; L David Sibley; Kenneth M Murphy
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.
Immunity 2011;35(2):249-59.
2011: Alexandre Esteban; Hidde L Ploegh; Maximilian W Popp; Karin Strijbis; Valmik K Vyas; Gerald R Fink
Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14270-5.
2011: Jan E Carette; Carla P Guimaraes; Markus K Muellner; Sebastian M B Nijman; Hidde L Ploegh; Chong Sun; Malini Varadarajan; Irene Wuethrich; Bingbing Yuan; George Bell; Vincent A Blomen; Thijn R Brummelkamp
Global gene disruption in human cells to assign genes to phenotypes by deep sequencing.
Nature biotechnology 2011;29(6):542-6.
2011: Ludovico Buti; Eric Spooner; Annemarthe G Van der Veen; Rino Rappuoli; Antonello Covacci; Hidde L Ploegh
Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(22):9238-43.
2011: Maximilian Wei-Lin Popp; Hidde L Ploegh
Making and breaking peptide bonds: protein engineering using sortase.
Angewandte Chemie (International ed. in English) 2011;50(22):5024-32.
2011: Boyoun Park; Ludovico Buti; Sungwook Lee; Takashi Matsuwaki; Eric Spooner; Melanie M Brinkmann; Masugi Nishihara; Hidde L Ploegh
Granulin is a soluble cofactor for toll-like receptor 9 signaling.
Immunity 2011;34(4):505-13.
2011: Robert Ernst; Jasper H L Claessen; Britta Mueller; Sumana Sanyal; Eric Spooner; Annemarthe G van der Veen; Oktay Kirak; Christian D Schlieker; Wilhelm A Weihofen; Hidde L Ploegh
Enzymatic blockade of the ubiquitin-proteasome pathway.
PLoS biology 2011;8(3):e1000605.
2011: Stephanie K Dougan; Chih-Chi Andrew Hu; Marie-Eve Paquet; Matthew B Greenblatt; Jun Kim; Brendan N Lilley; Nicki Watson; Hidde L Ploegh
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes.
Molecular and cellular biology 2011;31(6):1145-59.
2011: Katerina Artavanis-Tsakonas; Pia Kasperkovitz; Eliseo Papa; Michael L Cardenas; Nida S Khan; Annemarthe G Van der Veen; Hidde L Ploegh; Jatin M Vyas
The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification.
Infection and immunity 2011;79(3):1098-106.
2011: Maximilian W Popp; Stephanie K Dougan; Tzu-Ying Chuang; Eric Spooner; Hidde L Ploegh
Sortase-catalyzed transformations that improve the properties of cytokines.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3169-74.
2011: Annemarthe G Van der Veen; Kenji Schorpp; Christian Schlieker; Ludovico Buti; Jadyn R Damon; Eric Spooner; Hidde L Ploegh; Stefan Jentsch
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(5):1763-70.
2011: Sebastian Virreira Winter; Barbara A Burleigh; Kacey Caradonna; Kirk D Jensen; Lindsay Julien; Wendy Niedelman; Hidde L Ploegh; Emily E Rosowski; Jeroen P J Saeij; Eric Spooner; Eva-Maria Frickel
Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.
PloS one 2011;6(9):e24434.
2011: Annette M McGehee; Karin Strijbis; Eduardo Guillen; Thomas Eng; Oktay Kirak; Hidde L Ploegh
Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.
PloS one 2011;6(4):e18817.
2010: Boyoun Park; Eric Spooner; Brandy L Houser; Jack L Strominger; Hidde L Ploegh
The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation.
The Journal of experimental medicine 2010;207(9):2033-41.
2010: Ramanujan S Hegde; Hidde L Ploegh
Quality and quantity control at the endoplasmic reticulum.
Current opinion in cell biology 2010;22(4):437-46.
2010: Jasper H L Claessen; Britta Mueller; Eric Spooner; Valerie L Pivorunas; Hidde L Ploegh
The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.
The Journal of biological chemistry 2010;285(27):20732-9.
2010: Oktay Kirak; Eva-Maria Frickel; Gijsbert M Grotenbreg; Heikyung Suh; Rudolf Jaenisch; Hidde L Ploegh
Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.
Science (New York, N.Y.) 2010;328(5975):243-8.
2010: Paul L Greer; Rikinari Hanayama; Brenda L Bloodgood; Alan R Mardinly; David M Lipton; Steven W Flavell; Tae-kyung Kim; Eric C Griffith; Zachary Waldon; Rene Maehr; Hidde L Ploegh; Shoaib Chowdhury; Paul F Worley; Judith Steen; Michael E Greenberg
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.
Cell 2010;140(5):704-16.
2010: Douglas C Wilson; Gijsbert M Grotenbreg; Kenian Liu; Yanlin Zhao; Eva-Maria Frickel; Marc-Jan Gubbels; Hidde L Ploegh; George S Yap
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
PLoS pathogens 2010;6(3):e1000815.
2010: Katerina Artavanis-Tsakonas; Wilhelm A Weihofen; John M Antos; Bradley I Coleman; Christy A Comeaux; Manoj T Duraisingh; Rachelle Gaudet; Hidde L Ploegh
Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3.
The Journal of biological chemistry 2010;285(9):6857-66.
2010: Renuka K Pandya; James R Partridge; Kerry Routenberg Love; Thomas U Schwartz; Hidde L Ploegh
A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.
The Journal of biological chemistry 2010;285(8):5664-73.
2010: Oktay Kirak; Eva-Maria Frickel; Gijsbert M Grotenbreg; Heikyung Suh; Rudolf Jaenisch; Hidde L Ploegh
Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.
Journal of visualized experiments : JoVE 2010;(43):.
2009: Jan E Carette; Carla P Guimaraes; Malini Varadarajan; Annie S Park; Irene Wuethrich; Alzbeta Godarova; Maciej Kotecki; Brent H Cochran; Eric Spooner; Hidde L Ploegh; Thijn R Brummelkamp
Haploid genetic screens in human cells identify host factors used by pathogens.
Science (New York, N.Y.) 2009;326(5957):1231-5.
2009: Chih-Chi Andrew Hu; Stephanie K Dougan; Sebastian Virreira Winter; Adrienne W Paton; James C Paton; Hidde L Ploegh
Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes.
The Journal of experimental medicine 2009;206(11):2429-40.
2009: Robert Ernst; Britta Mueller; Hidde L Ploegh; Christian Schlieker
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
Molecular cell 2009;36(1):28-38.
2009: Sara Gredmark-Russ; Marisa K Isaacson; Lisa Kattenhorn; Evelyn J Cheung; Nicki Watson; Hidde L Ploegh
A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection.
Journal of virology 2009;83(20):10644-52.
2009: Annette M McGehee; Stephanie K Dougan; Elizabeth J Klemm; Guanghou Shui; Boyoun Park; you-me kim; Nicki Watson; Markus R Wenk; Hidde L Ploegh; Chih-Chi Andrew Hu
XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3690-9.
2009: John M Antos; Guo-Liang Chew; Carla P Guimaraes; Nicholas C Yoder; Gijsbert M Grotenbreg; Maximilian Wei-Lin Popp; Hidde L Ploegh
Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity.
Journal of the American Chemical Society 2009;131(31):10800-1.
2009: Cristina Maria Costantino; Hidde L Ploegh; David A Hafler
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):945-52.
2009: Marisa K Isaacson; Hidde L Ploegh
Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection.
Cell host & microbe 2009;5(6):559-70.
2009: John M Antos; Maximilian Wei-Lin Popp; Robert Ernst; Guo-Liang Chew; Eric Spooner; Hidde L Ploegh
A straight path to circular proteins.
The Journal of biological chemistry 2009;284(23):16028-36.
2009: Chih-Chi Andrew Hu; Stephanie K Dougan; Annette M McGehee; J Christopher Love; Hidde L Ploegh
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.
The EMBO journal 2009;28(11):1624-36.
2009: Kerry Routenberg Love; Renuka K Pandya; Eric Spooner; Hidde L Ploegh
Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery.
ACS chemical biology 2009;4(4):275-87.
2009: Maximilian Wei-Lin Popp; John M Antos; Hidde L Ploegh
Site-specific protein labeling via sortase-mediated transpeptidation.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2009;Chapter 15():Unit 15.3.
2009: Maximilian W Popp; Katerina Artavanis-Tsakonas; Hidde L Ploegh
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
The Journal of biological chemistry 2009;284(6):3593-602.
2008: John M Antos; Gwenn M Miller; Gijsbert M Grotenbreg; Hidde L Ploegh
Lipid modification of proteins through sortase-catalyzed transpeptidation.
Journal of the American Chemical Society 2008;130(48):16338-43.
2008: Boyoun Park; Melanie M Brinkmann; Eric Spooner; Clarissa C Lee; you-me kim; Hidde L Ploegh
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.
Nature immunology 2008;9(12):1407-14.
2008: Sara Gredmark-Russ; Evelyn J Cheung; Marisa K Isaacson; Hidde L Ploegh; Gijsbert M Grotenbreg
The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens.
Journal of virology 2008;82(24):12205-12.
2008: Eva-Maria Frickel; Nivedita Sahoo; Johnathan Hopp; Marc-Jan Gubbels; Mary Patricia J Craver; Laura J Knoll; Hidde L Ploegh; Gijsbert M Grotenbreg
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes.
The Journal of infectious diseases 2008;198(11):1625-33.
2008: Christian D Schlieker; Annemarthe G Van der Veen; Jadyn R Damon; Eric Spooner; Hidde L Ploegh
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18255-60.
2008: Craig M Story; Eliseo Papa; Chih-Chi Andrew Hu; Jehnna L Ronan; Kara Herlihy; Hidde L Ploegh; J Christopher Love
Profiling antibody responses by multiparametric analysis of primary B cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17902-7.
2008: Elizabeth M Bradshaw; Sally C Kent; Vinay Tripuraneni; Tihamer Orban; Hidde L Ploegh; David A Hafler; J Christopher Love
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.
Clinical immunology (Orlando, Fla.) 2008;129(1):10-8.
2008: Britta Mueller; Elizabeth J Klemm; Eric Spooner; Jasper H Claessen; Hidde L Ploegh
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12325-30.
2008: Jatin M Vyas; Annemarthe G Van der Veen; Hidde L Ploegh
The known unknowns of antigen processing and presentation.
Nature reviews. Immunology 2008;8(8):607-18.
2008: you-me kim; Melanie M Brinkmann; Marie-Eve Paquet; Hidde L Ploegh
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.
Nature 2008;452(7184):234-8.
2008: Gijsbert M Grotenbreg; Nadia R Roan; Eduardo Guillen; Rob Meijers; Jia-huai Wang; George W Bell; Michael N Starnbach; Hidde L Ploegh
Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3831-6.
2008: Cristina M Costantino; Howard C Hang; Sally C Kent; David A Hafler; Hidde L Ploegh
Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2876-85.
2008: Edith Kario; Boaz Tirosh; Hidde L Ploegh; Ami Navon
N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation.
The Journal of biological chemistry 2008;283(1):244-54.
2007: Keith W Jarosinski; Lisa Kattenhorn; Benedikt Kaufer; Hidde L Ploegh; Nikolaus Osterrieder
A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):20025-30.
2007: Hidde L Ploegh
Bridging B cell and T cell recognition of antigen.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7193.
2007: Hidde L Ploegh
Hidde Ploegh: immunologist, journeyman. Interview by Nicole LeBrasseur.
The Journal of cell biology 2007;179(3):364-5.
2007: Kerry Routenberg Love; Andre Catic; Christian Schlieker; Hidde L Ploegh
Mechanisms, biology and inhibitors of deubiquitinating enzymes.
Nature chemical biology 2007;3(11):697-705.
2007: Maximilian Popp; John M Antos; Gijsbert M Grotenbreg; Eric Spooner; Hidde L Ploegh
Sortagging: a versatile method for protein labeling.
Nature chemical biology 2007;3(11):707-8.
2007: Hidde L Ploegh
The peptide cargo of class I molecules: not just passive passengers.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4299-300.
2007: Katja Derkow; Christoph Loddenkemper; Justine D Mintern; Nils Kruse; Katja Klugewitz; Thomas Berg; Bertram Wiedenmann; Hidde L Ploegh; Eckart Schott
Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis.
Hepatology (Baltimore, Md.) 2007;46(4):1155-65.
2007: Sara Gredmark; Christian Schlieker; Victor Quesada; Eric Spooner; Hidde L Ploegh
A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.
Journal of virology 2007;81(19):10300-9.
2007: Hidde L Ploegh
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.
Nature 2007;448(7152):435-8.
2007: Andre Catic; Zhen-Yu J Sun; Daniel M Ratner; Shahram Misaghi; Eric Spooner; John Samuelson; Gerhard Wagner; Hidde L Ploegh
Sequence and structure evolved separately in a ribosomal ubiquitin variant.
The EMBO journal 2007;26(14):3474-83.
2007: Gijsbert M Grotenbreg; Melissa Call; Kevin D Fowler; Kathrin Wilbuer; Leah Octavio; Maxine Yang; Arup K Chakraborty; Hidde L Ploegh; Kai W Wucherpfennig
Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.
The Journal of biological chemistry 2007;282(29):21425-36.
2007: you-me kim; Melanie M Brinkmann; Hidde L Ploegh
TLRs bent into shape.
Nature immunology 2007;8(7):675-7.
2007: Kwon-Yul Ryu; Rene Maehr; Catherine A Gilchrist; Michael Long; Donna M Bouley; Britta Mueller; Hidde L Ploegh; Ron R Kopito
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.
The EMBO journal 2007;26(11):2693-706.
2007: Jatin M Vyas; you-me kim; Katerina Artavanis-Tsakonas; J Christopher Love; Annemarthe G Van der Veen; Hidde L Ploegh
Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7199-210.
2007: Eva-Maria Frickel; Víctor Quesada; Larissa Muething; Marc-Jan Gubbels; Eric Spooner; Hidde L Ploegh; Katerina Artavanis-Tsakonas
Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution.
Cellular microbiology 2007;9(6):1601-10.
2007: Gijsbert Grotenbreg; Hidde L Ploegh
Chemical biology: dressed-up proteins.
Nature 2007;446(7139):993-5.
2007: Melanie M Brinkmann; Eric Spooner; Kasper Hoebe; Bruce Beutler; Hidde L Ploegh; you-me kim
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.
The Journal of cell biology 2007;177(2):265-75.
2007: Howard C Hang; Ernst-Jan Geutjes; Gijsbert Grotenbreg; Annette M Pollington; Marie Jose Bijlmakers; Hidde L Ploegh
Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells.
Journal of the American Chemical Society 2007;129(10):2744-5.
2007: Irina C Gavanescu; Benedikt Kessler; Hidde L Ploegh; Christophe Benoist; Diane Mathis
Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4583-7.
2007: Christian Schlieker; Wilhelm A Weihofen; Evelyne Frijns; Lisa M Kattenhorn; Rachelle Gaudet; Hidde L Ploegh
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.
Molecular cell 2007;25(5):677-87.
2007: Kaori Kumazaki; Boaz Tirosh; Rene Maehr; Marianne Boes; Tasuku Honjo; Hidde L Ploegh
AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2192-203.
2007: Andre Catic; Edda Fiebiger; Gregory A Korbel; Daniël Blom; Paul J Galardy; Hidde L Ploegh
Screen for ISG15-crossreactive deubiquitinases.
PloS one 2007;2(7):e679.
2007: Andre Catic; Shahram Misaghi; Gregory A Korbel; Hidde L Ploegh
ElaD, a Deubiquitinating protease expressed by E. coli.
PloS one 2007;2(4):e381.
2006: Howard C Hang; Joana Loureiro; Eric Spooner; Adrianus W M van der Velden; you-me kim; Annette M Pollington; Rene Maehr; Michael N Starnbach; Hidde L Ploegh
Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.
ACS chemical biology 2006;1(11):713-23.
2006: Justine D Mintern; Elizabeth J Klemm; Markus Wagner; Marie Eve Paquet; Melanie D Napier; you-me kim; Ulrich H Koszinowski; Hidde L Ploegh
Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8422-31.
2006: Mridula Vishwanath; Akiko Nishibu; Sem Saeland; Brant R Ward; Norikatsu Mizumoto; Hidde L Ploegh; Marianne Boes; Akira Takashima
Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover.
The Journal of investigative dermatology 2006;126(11):2452-7.
2006: Katerina Artavanis-Tsakonas; J Christopher Love; Hidde L Ploegh; Jatin M Vyas
Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):15945-50.
2006: Britta Mueller; Brendan N Lilley; Hidde L Ploegh
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.
The Journal of cell biology 2006;175(2):261-70.
2006: Katerina Artavanis-Tsakonas; Shahram Misaghi; Christy A Comeaux; Andre Catic; Eric Spooner; Manoj T Duraisingh; Hidde L Ploegh
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.
Molecular microbiology 2006;61(5):1187-95.
2006: Brendan N Lilley; Joanna M Gilbert; Hidde L Ploegh; Thomas L Benjamin
Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection.
Journal of virology 2006;80(17):8739-44.
2006: Katherine S Koch; Kyung-Hwa Son; Rene Maehr; Illenia Pellicciotta; Hidde L Ploegh; Maurizio Zanetti; Stewart Sell; Hyam L Leffert
Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines.
Immunology 2006;119(1):98-115.
2006: Heide Christine K Patterson; Manfred Kraus; you-me kim; Hidde L Ploegh; Klaus Rajewsky
The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain.
Immunity 2006;25(1):55-65.
2006: Reshma Shringarpure; Laurence Catley; Deepak Bhole; Renate Burger; klaus podar; Yu-Tzu Tai; Benedikt Kessler; Paul J Galardy; Hidde L Ploegh; Pierfrancesco Tassone; Teru Hideshima; Constantine S Mitsiades; Nikhil C Munshi; Dharminder Chauhan; Kenneth C Anderson
Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib.
British journal of haematology 2006;134(2):145-56.
2006: Shahram Misaghi; Zarine R Balsara; Andre Catic; Eric Spooner; Hidde L Ploegh; Michael N Starnbach
Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection.
Molecular microbiology 2006;61(1):142-50.
2006: Joana Loureiro; Brendan N Lilley; Eric Spooner; Vanessa Noriega; Domenico Tortorella; Hidde L Ploegh
Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.
Nature 2006;441(7095):894-7.
2006: Alessandra Di Bacco; Jian Ouyang; Hsiang-Ying Lee; Andre Catic; Hidde L Ploegh; Grace Gill
The SUMO-specific protease SENP5 is required for cell division.
Molecular and cellular biology 2006;26(12):4489-98.
2006: Jianlei Wang; Amy N Loveland; Lisa M Kattenhorn; Hidde L Ploegh; D GIBSON
High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable.
Journal of virology 2006;80(12):6003-12.
2006: J Christopher Love; Jehnna L Ronan; Gijsbert M Grotenbreg; Annemarthe G van der Veen; Hidde L Ploegh
A microengraving method for rapid selection of single cells producing antigen-specific antibodies.
Nature biotechnology 2006;24(6):703-7.
2006: Tony T Huang; Sebastian M B Nijman; Kanchan D Mirchandani; Paul J Galardy; Martin A Cohn; Wilhelm Haas; Steven P Gygi; Hidde L Ploegh; René Bernards; Alan D D'Andrea
Regulation of monoubiquitinated PCNA by DUB autocleavage.
Nature cell biology 2006;8(4):339-47.
2006: Akiko Nishibu; Brant R Ward; James V Jester; Hidde L Ploegh; Marianne Boes; Akira Takashima
Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli.
The Journal of investigative dermatology 2006;126(4):787-96.
2006: Boaz Tirosh; Neal N Iwakoshi; Laurie H Glimcher; Hidde L Ploegh
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response.
The Journal of biological chemistry 2006;281(9):5852-60.
2006: Michael Groll; Celia R Berkers; Hidde L Ploegh; Huib Ovaa
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.
Structure (London, England : 1993) 2006;14(3):451-6.
2006: you-me kim; Jennifer Yi-Jiun Pan; Gregory A Korbel; Victor Peperzak; Marianne Boes; Hidde L Ploegh
Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3327-32.
2006: Joana Loureiro; Hidde L Ploegh
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.
Advances in immunology 2006;92():225-305.
2006: Shahram Misaghi; Gregory A Korbel; B Kessler; Eric Spooner; Hidde L Ploegh
z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress.
Cell death and differentiation 2006;13(1):163-5.
2005: Christian Schlieker; Gregory A Korbel; Lisa M Kattenhorn; Hidde L Ploegh
A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae.
Journal of virology 2005;79(24):15582-5.
2005: Christopher Anderson; Stephen Crimmins; Julie A Wilson; Greg A Korbel; Hidde L Ploegh; Scott Michael Wilson
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice.
Journal of neurochemistry 2005;95(3):724-31.
2005: Andre Catic; Hidde L Ploegh
Ubiquitin--conserved protein or selfish gene?
Trends in biochemical sciences 2005;30(11):600-4.
2005: Brendan N Lilley; Hidde L Ploegh
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14296-301.
2005: Rene Maehr; Justine D Mintern; Ann E Herman; Ana-Maria Lennon-Duménil; Diane Mathis; Christophe Benoist; Hidde L Ploegh
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.
The Journal of clinical investigation 2005;115(10):2934-43.
2005: Brendan N Lilley; Hidde L Ploegh
Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond.
Immunological reviews 2005;207():126-44.
2005: Mikael Altun; Paul J Galardy; Reshma Shringarpure; Teru Hideshima; Richard LeBlanc; Kenneth C Anderson; Hidde L Ploegh; Benedikt M Kessler
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells.
Cancer research 2005;65(17):7896-901.
2005: Marianne Boes; Nicole N Van Der Wel; Victor Peperzak; you-me kim; Peter J Peters; Hidde L Ploegh
In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S.
European journal of immunology 2005;35(9):2552-62.
2005: Lisa M Kattenhorn; Gregory A Korbel; Benedikt M Kessler; Eric Spooner; Hidde L Ploegh
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae.
Molecular cell 2005;19(4):547-57.
2005: Boaz Tirosh; Neal N Iwakoshi; Laurie H Glimcher; Hidde L Ploegh
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells.
The Journal of experimental medicine 2005;202(4):505-16.
2005: Hidde L Ploegh
A molecule's right to choose: how diabetogenic class II MHC products bind peptides.
The Journal of clinical investigation 2005;115(8):2077-9.
2005: Huang-Chun Tseng; Huib Ovaa; Nancy J C Wei; Hidde L Ploegh; Li-Huei Tsai
Phosphoproteomic analysis with a solid-phase capture-release-tag approach.
Chemistry & biology 2005;12(7):769-77.
2005: Lina Guerra; Ken Teter; Brendan N Lilley; Bo Stenerlöw; Randall K Holmes; Hidde L Ploegh; Kirsten Sandvig; Monica Thelestam; Teresa Frisan
Cellular internalization of cytolethal distending toxin: a new end to a known pathway.
Cellular microbiology 2005;7(7):921-34.
2005: Rene Maehr; Howard C Hang; Justine D Mintern; you-me kim; Armelle Cuvillier; Mikio Nishimura; Kenji Yamada; Kanae Shirahama-Noda; Ikuko Hara-Nishimura; Hidde L Ploegh
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7066-74.
2005: Lara J Ausubel; Kevin C O'Connor; Clare Baecher-Allen; Christina Trollmo; Benedikt Kessler; Brian Hekking; David Merritt; Abbie L Meyer; Bill Kwok; Hidde L Ploegh; Brigitte T Huber; David A Hafler
Characterization of in vivo expanded OspA-specific human T-cell clones.
Clinical immunology (Orlando, Fla.) 2005;115(3):313-22.
2005: Celia R Berkers; Martijn Verdoes; Eben Lichtman; Edda Fiebiger; Benedikt M Kessler; Kenneth C Anderson; Hidde L Ploegh; Huib Ovaa; Paul J Galardy
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib.
Nature methods 2005;2(5):357-62.
2005: Boaz Tirosh; Neal N Iwakoshi; Brendan N Lilley; Ann-Hwee Lee; Laurie H Glimcher; Hidde L Ploegh
Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products.
Journal of virology 2005;79(5):2768-79.
2005: Anna Borodovsky; Huib Ovaa; Wim J N Meester; Emily Venanzi; Matthew Bogyo; Brian G Hekking; Hidde L Ploegh; Benedikt M Kessler; Herman S Overkleeft
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases.
Chembiochem : a European journal of chemical biology 2005;6(2):287-91.
2005: Edda Fiebiger; Domenico Tortorella; Marie-Hélène Jouvin; Jean-Pierre Kinet; Hidde L Ploegh
Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors.
The Journal of experimental medicine 2005;201(2):267-77.
2005: Niess Jan; Stephan Brand; Xiubin Gu; Limor Landsman; Steffen Jung; Beth A McCormick; Jatin M Vyas; Marianne Boes; Hidde L Ploegh; James G Fox; Dan R Littman; Hans-Christian Reinecker
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.
Science (New York, N.Y.) 2005;307(5707):254-8.
2005: Shahram Misaghi; Paul J Galardy; Wim J N Meester; Huib Ovaa; Hidde L Ploegh; Rachelle Gaudet
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate.
The Journal of biological chemistry 2005;280(2):1512-20.
2005: Huib Ovaa; Paul J Galardy; Hidde L Ploegh
Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: synthesis of active site-directed probes.
Methods in enzymology 2005;399():468-78.
2005: Paul J Galardy; Hidde L Ploegh; Huib Ovaa
Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification.
Methods in enzymology 2005;399():120-31.
2004: Andre Catic; Cal Collins; George M Church; Hidde L Ploegh
Preferred in vivo ubiquitination sites.
Bioinformatics (Oxford, England) 2004;20(18):3302-7.
2004: Shahram Misaghi; Michael E Pacold; Daniël Blom; Hidde L Ploegh; Gregory A Korbel
Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover.
Chemistry & biology 2004;11(12):1677-87.
2004: Gijsbert A van der Marel; Hidde L Ploegh
Obituary: Jacques H. van Boom (1937-2004).
Nature 2004;431(7010):755.
2004: Howard C Hang; Hidde L Ploegh
Catching proteases in action with microarrays.
Chemistry & biology 2004;11(10):1328-30.
2004: Lisa M Kattenhorn; Ryan Mills; Markus Wagner; Alexandre Lomsadze; Vsevolod Makeev; Mark Borodovsky; Hidde L Ploegh; Benedikt M Kessler
Identification of proteins associated with murine cytomegalovirus virions.
Journal of virology 2004;78(20):11187-97.
2004: Till A Röhn; Marianne Boes; Dirk Wolters; Sebastian Spindeldreher; Bernd Müller; Hanno Langen; Hidde L Ploegh; Anne B Vogt; Harald Kropshofer
Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.
Nature immunology 2004;5(9):909-18.
2004: Stephen C Harrison; Bruce Alberts; Ellie Ehrenfeld; Lynn Enquist; Harvey V Fineberg; Steven L McKnight; Bernard Moss; Michael O'Donnell; Hidde L Ploegh; Sandra L Schmid; K Peter Walter; Julie A Theriot
Discovery of antivirals against smallpox.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(31):11178-92.
2004: Rene Maehr; Manfred Kraus; Hidde L Ploegh
Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment.
European journal of immunology 2004;34(8):2230-6.
2004: Marianne Boes; Hidde L Ploegh
Translating cell biology in vitro to immunity in vivo.
Nature 2004;430(6996):264-71.
2004: Brendan N Lilley; Hidde L Ploegh
A membrane protein required for dislocation of misfolded proteins from the ER.
Nature 2004;429(6994):834-40.
2004: Paul F van Swieten; Rene Maehr; Adrianus M C H van den Nieuwendijk; Benedikt M Kessler; Michael Reich; Chung-Sing Wong; Hubert Kalbacher; Michiel A Leeuwenburgh; Christoph Driessen; Gijsbert A van der Marel; Hidde L Ploegh; Herman S Overkleeft
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.
Bioorganic & medicinal chemistry letters 2004;14(12):3131-4.
2004: Hidde L Ploegh
Immunology. Nothing 'gainst time's scythe can make defense...
Science (New York, N.Y.) 2004;304(5675):1262-3.
2004: Marianne Boes; Armelle Cuvillier; Hidde L Ploegh
Membrane specializations and endosome maturation in dendritic cells and B cells.
Trends in cell biology 2004;14(4):175-83.
2004: Edda Fiebiger; Christian Hirsch; Jatin M Vyas; Eva Gordon; Hidde L Ploegh; Domenico Tortorella
Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin.
Molecular biology of the cell 2004;15(4):1635-46.
2004: Marc Schmidt-Supprian; Jane Tian; Ethan P Grant; Manolis Pasparakis; Rene Maehr; Huib Ovaa; Hidde L Ploegh; Anthony J Coyle; Klaus Rajewsky
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4566-71.
2004: Deborah Palliser; Hidde L Ploegh; Marianne Boes
Myeloid differentiation factor 88 is required for cross-priming in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3415-21.
2004: Paul C Evans; Huib Ovaa; Maureen Hamon; Peter J Kilshaw; Svetlana Hamm; Stefan Bauer; Hidde L Ploegh; Trevor S Smith
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.
The Biochemical journal 2004;378(Pt 3):727-34.
2004: Haim Y Cohen; Siva Lavu; Kevin J Bitterman; Brian Hekking; Thomas A Imahiyerobo; Christine Miller; Roy Frye; Hidde L Ploegh; Benedikt M Kessler; David A Sinclair
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
Molecular cell 2004;13(5):627-38.
2004: Joris Hemelaar; Paul J Galardy; Anna Borodovsky; Benedikt M Kessler; Hidde L Ploegh; Huib Ovaa
Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases.
Journal of proteome research 2004;3(2):268-76.
2004: Huib Ovaa; Benedikt M Kessler; Ulrika Rolén; Paul J Galardy; Hidde L Ploegh; Maria Masucci
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2253-8.
2004: Daniël Blom; Christian Hirsch; Patrick Stern; Domenico Tortorella; Hidde L Ploegh
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised.
The EMBO journal 2004;23(3):650-8.
2004: Beatriz C Gil-Torregrosa; Ana-Maria Lennon-Duménil; Benedikt Kessler; Pierre Guermonprez; Hidde L Ploegh; Doriana Fruci; Peter van Endert; Sebastian Amigorena
Control of cross-presentation during dendritic cell maturation.
European journal of immunology 2004;34(2):398-407.
2004: Paula Bryant; Hidde L Ploegh
Class II MHC peptide loading by the professionals.
Current opinion in immunology 2004;16(1):96-102.
2004: Christian Hirsch; Shahram Misaghi; Daniël Blom; Michael E Pacold; Hidde L Ploegh
Yeast N-glycanase distinguishes between native and non-native glycoproteins.
EMBO reports 2004;5(2):201-6.
2004: Justine D Mintern; Madelon M Maurice; Hidde L Ploegh; Eckart Schott
Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):699-708.
2004: Eric A Grovender; Brenda A Kellogg; Jasleen Singh; Daniel Blom; Hidde L Ploegh; K Dane Wittrup; Robert S Langer; Guillermo A Ameer
Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin.
Kidney international 2004;65(1):310-22.
2004: Joris Hemelaar; Anna Borodovsky; Benedikt M Kessler; David Reverter; Julie Cook; Nagamalleswari Kolli; Tudeviin Gan-Erdene; Keith Wilkinson; Grace Gill; Christopher D Lima; Hidde L Ploegh; Huib Ovaa
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.
Molecular and cellular biology 2004;24(1):84-95.
2004: Shahram Misaghi; Zhen-Yu J Sun; Patrick Stern; Rachelle Gaudet; Gerhard Wagner; Hidde L Ploegh
Structural and functional analysis of human cytomegalovirus US3 protein.
Journal of virology 2004;78(1):413-23.
2003: Joris Hemelaar; Victor S Lelyveld; Benedikt M Kessler; Hidde L Ploegh
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L.
The Journal of biological chemistry 2003;278(51):51841-50.
2003: Jean Pieters; Hidde L Ploegh
Microbiology. Chemical warfare and mycobacterial defense.
Science (New York, N.Y.) 2003;302(5652):1900-2.
2003: Nicolas Bertho; Jan Cerny; you-me kim; Edda Fiebiger; Hidde L Ploegh; Marianne Boes
Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5689-96.
2003: amy hudson; Daniël Blom; Peter M Howley; Hidde L Ploegh
The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes.
Traffic (Copenhagen, Denmark) 2003;4(12):824-37.
2003: Christine Kocks; Rene Maehr; Herman S Overkleeft; Evelyn W Wang; Lackshmanan K Iyer; Ana-Maria Lennon-Dumenil; Hidde L Ploegh; Benedikt M Kessler
Functional proteomics of the active cysteine protease content in Drosophila S2 cells.
Molecular & cellular proteomics : MCP 2003;2(11):1188-97.
2003: Eckart Schott; Roberto Bonasio; Hidde L Ploegh
Elimination in vivo of developing T cells by natural killer cells.
The Journal of experimental medicine 2003;198(8):1213-24.
2003: Marianne Boes; Nicolas Bertho; Jan Cerny; Marjolein Op den Brouw; Tomas Kirchhausen; Hidde L Ploegh
T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4081-8.
2003: Alexei F Kisselev; Margarita Garcia-Calvo; Herman S Overkleeft; Erin Peterson; Michael Pennington; Hidde L Ploegh; Nancy A Thornberry; Alfred L Goldberg
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.
The Journal of biological chemistry 2003;278(38):35869-77.
2003: Margo H Furman; Joana Loureiro; Hidde L Ploegh; Domenico Tortorella
Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum.
The Journal of biological chemistry 2003;278(37):34804-11.
2003: Brendan N Lilley; Domenico Tortorella; Hidde L Ploegh
Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer.
Molecular biology of the cell 2003;14(9):3690-8.
2003: Huib Ovaa; Paul F van Swieten; Benedikt M Kessler; Michiel A Leeuwenburgh; Edda Fiebiger; Adrianus M C H van den Nieuwendijk; Paul J Galardy; Gijsbert A van der Marel; Hidde L Ploegh; Herman S Overkleeft
Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy.
Angewandte Chemie (International ed. in English) 2003;42(31):3626-9.
2003: Sarah E F D'Orazio; D G Halme; Hidde L Ploegh; Michael N Starnbach
Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):291-8.
2003: Benedikt Kessler; Xu Hong; Jelena Petrovic; Anna Borodovsky; Nico P Dantuma; Matthew Bogyo; Herman S Overkleeft; Hidde L Ploegh; Rickard Glas
Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production.
The Journal of biological chemistry 2003;278(12):10013-21.
2003: Christian Hirsch; Daniël Blom; Hidde L Ploegh
A role for N-glycanase in the cytosolic turnover of glycoproteins.
The EMBO journal 2003;22(5):1036-46.
2003: Boaz Tirosh; Margo H Furman; Domenico Tortorella; Hidde L Ploegh
Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation.
The Journal of biological chemistry 2003;278(9):6664-72.
2002: Wiltrud M Kalka-Moll; Arthur O Tzianabos; Paula W Bryant; Marcus Niemeyer; Hidde L Ploegh; Dennis L Kasper
Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6149-53.
2002: Eckart Schott; Hidde L Ploegh
Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells.
European journal of immunology 2002;32(12):3425-34.
2002: Edda Fiebiger; Rene Maehr; José Villadangos; Ekkehard Weber; Ann H Erickson; Elizabeth Bikoff; Hidde L Ploegh; Ana-Maria Lennon-Duménil
Invariant chain controls the activity of extracellular cathepsin L.
The Journal of experimental medicine 2002;196(9):1263-9.
2002: Yulia Vugmeyster; Anna Borodovsky; Madelon M Maurice; Rene Maehr; Margo H Furman; Hidde L Ploegh
The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP).
Molecular immunology 2002;39(7-8):431-41.
2002: Margo H Furman; Neelendu Dey; Domenico Tortorella; Hidde L Ploegh
The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules.
Journal of virology 2002;76(22):11753-6.
2002: Eckart Schott; Nicolas Bertho; Qing Ge; Madelon M Maurice; Hidde L Ploegh
Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13735-40.
2002: Anna Borodovsky; Huib Ovaa; Nagamalleswari Kolli; Tudeviin Gan-Erdene; Keith Wilkinson; Hidde L Ploegh; Benedikt M Kessler
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.
Chemistry & biology 2002;9(10):1149-59.
2002: Margo H Furman; Hidde L Ploegh
Lessons from viral manipulation of protein disposal pathways.
The Journal of clinical investigation 2002;110(7):875-9.
2002: Benedikt M Kessler; Rickard Glas; Hidde L Ploegh
MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation.
Molecular immunology 2002;39(3-4):171-9.
2002: David S Leggett; John Hanna; Anna Borodovsky; Bernat Crosas; Marion Schmidt; Rohan T Baker; Thomas Walz; Hidde L Ploegh; Daniel Finley
Multiple associated proteins regulate proteasome structure and function.
Molecular cell 2002;10(3):495-507.
2002: Marianne Boes; Jan Cerny; Ramiro Massol; Marjolein Op den Brouw; Tomas Kirchhausen; Jianzhu Chen; Hidde L Ploegh
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.
Nature 2002;418(6901):983-8.
2002: Ana-Maria Lennon-Duménil; Arnold H Bakker; Rene Maehr; Edda Fiebiger; Herman S Overkleeft; Mario Rosemblatt; Hidde L Ploegh; Cécile Lagaudrière-Gesbert
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.
The Journal of experimental medicine 2002;196(4):529-40.
2002: Rebecca Tirabassi; Hidde L Ploegh
The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products.
Journal of virology 2002;76(13):6832-5.
2002: Ute Felbor; Benedikt Kessler; Walther Mothes; Hans H Goebel; Hidde L Ploegh; Roderick T Bronson; Bjorn R Olsen
Neuronal loss and brain atrophy in mice lacking cathepsins B and L.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):7883-8.
2002: Mayra E Lorenzo; Jae U. Jung; Hidde L Ploegh
Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments.
Journal of virology 2002;76(11):5522-31.
2002: Armin Rehm; Arne Engelsberg; Domenico Tortorella; Ida J Körner; Insa Lehmann; Hidde L Ploegh; Uta E Höpken
Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
Journal of virology 2002;76(10):5043-50.
2002: Benjamin E Gewurz; Hidde L Ploegh; Domenico Tortorella
US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide.
The Journal of biological chemistry 2002;277(13):11306-13.
2002: Edda Fiebiger; Craig Story; Hidde L Ploegh; Domenico Tortorella
Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein.
The EMBO journal 2002;21(5):1041-53.
2002: Cécile Lagaudrière-Gesbert; Sherri L Newmyer; Tone F Gregers; Oddmund Bakke; Hidde L Ploegh
Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1515-20.
2002: Esther B E Plüger; Marianne Boes; Christopher Alfonso; Christian J Schröter; Hubert Kalbacher; Hidde L Ploegh; Christoph Driessen
Specific role for cathepsin S in the generation of antigenic peptides in vivo.
European journal of immunology 2002;32(2):467-76.
2002: Ana-Maria Lennon-Duménil; Arnold H Bakker; Paula Wolf-Bryant; Hidde L Ploegh; Cécile Lagaudrière-Gesbert
A closer look at proteolysis and MHC-class-II-restricted antigen presentation.
Current opinion in immunology 2002;14(1):15-21.
2002: Margo H Furman; Hidde L Ploegh; Domenico Tortorella
Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules.
The Journal of biological chemistry 2002;277(5):3258-67.
2002: Hidde L Ploegh
Don Craig Wiley (1944-2001).
Nature 2002;415(6871):492.
2002: Paula Wolf Bryant; Ana-Maria Lennon-Duménil; Edda Fiebiger; Cécile Lagaudrière-Gesbert; Hidde L Ploegh
Proteolysis and antigen presentation by MHC class II molecules.
Advances in immunology 2002;80():71-114.
2002: amy hudson; Hidde L Ploegh
The cell biology of antigen presentation.
Experimental cell research 2002;272(1):1-7.
2001: Richard J Riese; Guo-Ping Shi; José Villadangos; D Stetson; Christoph Driessen; A M Lennon-Dumenil; C L Chu; Y Naumov; S M Behar; Hidde L Ploegh; R Locksley; Harold A Chapman
Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.
Immunity 2001;15(6):909-19.
2001: amy hudson; Peter M Howley; Hidde L Ploegh
A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes.
Journal of virology 2001;75(24):12347-58.
2001: Brendan N Lilley; Hidde L Ploegh; Rebecca Tirabassi
Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein.
Journal of virology 2001;75(22):11218-21.
2001: DS Gould; Hidde L Ploegh; Daniel J Schust
Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells.
Journal of reproductive immunology 2001;52(1-2):85-99.
2001: Anna Borodovsky; Benedikt M Kessler; R Casagrande; Herman S Overkleeft; Keith Wilkinson; Hidde L Ploegh
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.
The EMBO journal 2001;20(18):5187-96.
2001: Benedikt M Kessler; Domenico Tortorella; Mikael Altun; Alexei F Kisselev; Edda Fiebiger; Brian Hekking; Hidde L Ploegh; Herman S Overkleeft
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.
Chemistry & biology 2001;8(9):913-29.
2001: CE Shamu; Dennis Flierman; Hidde L Ploegh; Tom A Rapoport; Vincent Chau
Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol.
Molecular biology of the cell 2001;12(8):2546-55.
2001: Benjamin E Gewurz; Rachelle Gaudet; Domenico Tortorella; Evelyn W Wang; Hidde L Ploegh
Virus subversion of immunity: a structural perspective.
Current opinion in immunology 2001;13(4):442-50.
2001: Ana-Maria Lennon-Duménil; R A Roberts; K Valentijn; Christoph Driessen; Herman S Overkleeft; Ann H Erickson; Peter J Peters; E Bikoff; Hidde L Ploegh; P Wolf Bryant
The p41 isoform of invariant chain is a chaperone for cathepsin L.
The EMBO journal 2001;20(15):4055-64.
2001: Madelon M Maurice; DS Gould; J Carroll; Yulia Vugmeyster; Hidde L Ploegh
Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7437-42.
2001: Benjamin E Gewurz; Rachelle Gaudet; Domenico Tortorella; Evelyn W Wang; Hidde L Ploegh; Don C Wiley
Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6794-9.
2001: Benjamin E Gewurz; Evelyn W Wang; Domenico Tortorella; Daniel J Schust; Hidde L Ploegh
Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner.
Journal of virology 2001;75(11):5197-204.
2001: Hidde L Ploegh
One-dimensional isoelectric focusing of proteins in slab gels.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.2.
2001: Christoph Driessen; Ana-Maria Lennon-Duménil; Hidde L Ploegh
Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors.
European journal of immunology 2001;31(5):1592-601.
2001: Armin Rehm; Patrick Stern; Hidde L Ploegh; Domenico Tortorella
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.
The EMBO journal 2001;20(7):1573-82.
2001: Guillermo A Ameer; E A Grovender; Hidde L Ploegh; David Ting; W F Owen; Maria A Rupnick; Robert Langer
A novel immunoadsorption device for removing beta2-microglobulin from whole blood.
Kidney international 2001;59(4):1544-50.
2001: M E Lorenzo; Hidde L Ploegh; Rebecca Tirabassi
Viral immune evasion strategies and the underlying cell biology.
Seminars in immunology 2001;13(1):1-9.
2000: Gobardhan Das; DS Gould; M M Augustine; G Fragoso; E Sciutto; I Stroynowski; Luc Van Kaer; Daniel J Schust; Hidde L Ploegh; Charles A Janeway; E Scitto
Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes.
The Journal of experimental medicine 2000;192(10):1521-8.
2000: MH Furman; Hidde L Ploegh; Daniel J Schust
Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface?
Human immunology 2000;61(11):1169-76.
2000: Evelyn W Wang; Benedikt M Kessler; Anna Borodovsky; Benjamin F Cravatt; Matthew Bogyo; Hidde L Ploegh; Rickard Glas
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):9990-5.
2000: C Hirsch; Hidde L Ploegh
Intracellular targeting of the proteasome.
Trends in cell biology 2000;10(7):268-72.
2000: Domenico Tortorella; Benjamin E Gewurz; Daniel J Schust; MH Furman; Hidde L Ploegh
Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology.
Immunological investigations 2000;29(2):97-100.
2000: Guo-Ping Shi; RA Bryant; Richard J Riese; Steven H L Verhelst; Christoph Driessen; Zhenqiang Li; Dieter Bromme; Hidde L Ploegh; Harold A Chapman
Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.
The Journal of experimental medicine 2000;191(7):1177-86.
2000: R Casagrande; Patrick Stern; M Diehn; CE Shamu; M Osario; M Zúñiga; P O Brown; Hidde L Ploegh
Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway.
Molecular cell 2000;5(4):729-35.
2000: Ute Felbor; Lars Dreier; RA Bryant; Hidde L Ploegh; Bjorn R Olsen; Walther Mothes
Secreted cathepsin L generates endostatin from collagen XVIII.
The EMBO journal 2000;19(6):1187-94.
2000: José Villadangos; Christoph Driessen; Guo-Ping Shi; Harold A Chapman; Hidde L Ploegh
Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.
The EMBO journal 2000;19(5):882-91.
2000: Domenico Tortorella; Benjamin E Gewurz; MH Furman; Daniel J Schust; Hidde L Ploegh
Viral subversion of the immune system.
Annual review of immunology 2000;18():861-926.
1999: José Villadangos; RA Bryant; Jan M Deussing; Christoph Driessen; Ana-Maria Lennon-Duménil; Richard J Riese; Wera Roth; Paul Saftig; Guo-Ping Shi; Harold A Chapman; Christoph Peters; Hidde L Ploegh
Proteases involved in MHC class II antigen presentation.
Immunological reviews 1999;172():109-20.
1999: Christoph Driessen; RA Bryant; Ana-Maria Lennon-Duménil; José Villadangos; Paula Wolf Bryant; Guo-Ping Shi; Harold A Chapman; Hidde L Ploegh
Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.
The Journal of cell biology 1999;147(4):775-90.
1999: CE Shamu; Craig Story; Tom A Rapoport; Hidde L Ploegh
The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate.
The Journal of cell biology 1999;147(1):45-58.
1999: Joel D Taurog; Kirsten Fischer Lindahl; Robert E Hammer; CA Slaughter; SD Maika; M Zhou; Derry C Roopenian; Gregory J Christianson; SJ Gaskell; RC Jones; RS Bordoli; Hidde L Ploegh; B Galocha; SG Summerfield
A new MHC locus that influences class I peptide presentation.
Immunity 1999;11(4):following 506.
1999: Paula Wolf Bryant; P Roos; Hidde L Ploegh; Andrea J Sant
Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties.
European journal of immunology 1999;29(9):2729-39.
1999: Craig Story; Margo H Furman; Hidde L Ploegh
The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8516-21.
1999: Daniel J Schust; Domenico Tortorella; Hidde L Ploegh
Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens.
Journal of reproductive immunology 1999;43(2):243-51.
1999: John R Rodgers; Jonathan M Levitt; P Cresswell; Kirsten Fischer Lindahl; D Mathis; J T Monaco; dinah singer; Hidde L Ploegh; P W Bryant
A nomenclature solution to mouse MHC confusion.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6294.
1999: Daniel J Schust; Domenico Tortorella; Hidde L Ploegh
HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.
Seminars in cancer biology 1999;9(1):37-46.
1999: Guo-Ping Shi; José Villadangos; Glenn Dranoff; C Small; L Gu; K J Haley; Richard J Riese; Hidde L Ploegh; Harold A Chapman
Cathepsin S required for normal MHC class II peptide loading and germinal center development.
Immunity 1999;10(2):197-206.
1998: Yulia Vugmeyster; Rickard Glas; B Pérarnau; François A Lemonnier; H Eisen; Hidde L Ploegh
Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12492-7.
1998: Y Sykulev; Y Vugmeyster; A Brunmark; Hidde L Ploegh; Herman N Eisen
Peptide antagonism and T cell receptor interactions with peptide-MHC complexes.
Immunity 1998;9(4):475-83.
1998: P R Wolf; S Tourne; T Miyazaki; Christophe Benoist; Diane Mathis; Hidde L Ploegh
The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed.
European journal of immunology 1998;28(9):2605-18.
1998: Daniel J Schust; Domenico Tortorella; Jörg D Seebach; C Phan; Hidde L Ploegh
Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.
The Journal of experimental medicine 1998;188(3):497-503.
1998: Domenico Tortorella; Craig Story; J B Huppa; EJ Wiertz; T R Jones; Igor Bacik; Jack R Bennink; jon yewdell; Hidde L Ploegh
Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential.
The Journal of cell biology 1998;142(2):365-76.
1998: Matthew Bogyo; S Shin; JS McMaster; Hidde L Ploegh
Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes.
Chemistry & biology 1998;5(6):307-20.
1998: Richard J Riese; Richard N Mitchell; José Villadangos; Guo-Ping Shi; James Palmer; E R Karp; George T De Sanctis; Hidde L Ploegh; Harold A Chapman
Cathepsin S activity regulates antigen presentation and immunity.
The Journal of clinical investigation 1998;101(11):2351-63.
1998: Terry Nakagawa; Wera Roth; Phillip Wong; A Nelson; Andrew G Farr; Jan M Deussing; José Villadangos; Hidde L Ploegh; Christoph Peters; Alexander Y Rudensky
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
Science (New York, N.Y.) 1998;280(5362):450-3.
1998: Jan M Deussing; Wera Roth; Paul Saftig; Christoph Peters; Hidde L Ploegh; José Villadangos
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4516-21.
1998: Hidde L Ploegh
Viral strategies of immune evasion.
Science (New York, N.Y.) 1998;280(5361):248-53.
1998: Rickard Glas; Matthew Bogyo; JS McMaster; Maria Gaczynska; Hidde L Ploegh
A proteolytic system that compensates for loss of proteasome function.
Nature 1998;392(6676):618-22.
1998: M F Sernee; Hidde L Ploegh; Daniel J Schust
Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents.
Molecular immunology 1998;35(3):177-88.
1998: J B Huppa; Hidde L Ploegh
The eS-Sence of -SH in the ER.
Cell 1998;92(2):145-8.
1997: WA Simmons; Derry C Roopenian; SG Summerfield; RC Jones; B Galocha; Gregory J Christianson; SD Maika; M Zhou; SJ Gaskell; RS Bordoli; Hidde L Ploegh; CA Slaughter; Kirsten Fischer Lindahl; Robert E Hammer; Joel D Taurog
A new MHC locus that influences class I peptide presentation.
Immunity 1997;7(5):641-51.
1997: A Rehm; Hidde L Ploegh
The betagamma subunits of heterotrimeric G proteins acquire detergent insolubility directly at the plasma membrane.
FEBS letters 1997;416(1):39-44.
1997: José Villadangos; Richard J Riese; Christoph Peters; Harold A Chapman; Hidde L Ploegh
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism.
The Journal of experimental medicine 1997;186(4):549-60.
1997: JB Huppa; Hidde L Ploegh
In vitro translation and assembly of a complete T cell receptor-CD3 complex.
The Journal of experimental medicine 1997;186(3):393-403.
1997: JB Huppa; Hidde L Ploegh
The alpha chain of the T cell antigen receptor is degraded in the cytosol.
Immunity 1997;7(1):113-22.
1997: Matthew Bogyo; JS McMaster; Maria Gaczynska; Domenico Tortorella; Alfred L Goldberg; Hidde L Ploegh
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6629-34.
1997: B Galocha; Ann B Hill; B C Barnett; Aidan Dolan; A Raimondi; R F Cook; J Brunner; Duncan J McGeoch; Hidde L Ploegh
The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues.
The Journal of experimental medicine 1997;185(9):1565-72.
1997: A Rehm; Hidde L Ploegh
Assembly and intracellular targeting of the betagamma subunits of heterotrimeric G proteins.
The Journal of cell biology 1997;137(2):305-17.
1997: Cécile Lagaudrière-Gesbert; Sophie Lebel-Binay; E Wiertz; Hidde L Ploegh; Didier Fradelizi; HELENE CONJEAUD
The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2790-7.
1997: E J Wiertz; S Mukherjee; Hidde L Ploegh
Viruses use stealth technology to escape from the host immune system.
Molecular medicine today 1997;3(3):116-23.
1997: M F Kleijnen; JB Huppa; Pero Lucin; S Mukherjee; HE Farrell; Ann E Campbell; Ulrich H Koszinowski; Ann B Hill; Hidde L Ploegh
A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface.
The EMBO journal 1997;16(4):685-94.
1997: A Rehm; Hidde L Ploegh
Monoclonal antibodies that distinguish between free and complexed heterotrimeric G protein beta subunits.
FEBS letters 1997;402(2-3):277-85.
1997: R P Machold; E J Wiertz; T R Jones; Hidde L Ploegh
The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains.
The Journal of experimental medicine 1997;185(2):363-6.
1997: Matthew Bogyo; Maria Gaczynska; Hidde L Ploegh
Proteasome inhibitors and antigen presentation.
Biopolymers 1997;43(4):269-80.
1996: E J Wiertz; Domenico Tortorella; Matthew Bogyo; J Yu; Walther Mothes; T R Jones; Tom A Rapoport; Hidde L Ploegh
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.
Nature 1996;384(6608):432-8.
1996: R P Machold; Hidde L Ploegh
Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies.
The Journal of experimental medicine 1996;184(6):2251-9.
1996: D J Schust; Ann B Hill; Hidde L Ploegh
Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3375-80.
1996: Roman A Tomazin; Ann B Hill; P Jugovic; I York; P van Endert; Hidde L Ploegh; David W Andrews; David C Johnson
Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.
The EMBO journal 1996;15(13):3256-66.
1996: Mamadi Yilla; J Oleinick; Hidde L Ploegh
A monoclonal antibody that causes the heterotrimeric G-protein G(o) to release its beta gamma subunits.
FEBS letters 1996;387(1):16-22.
1996: Richard J Riese; P R Wolf; D Brömme; L R Natkin; José Villadangos; Hidde L Ploegh; Harold A Chapman
Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading.
Immunity 1996;4(4):357-66.
1996: E J Wiertz; T R Jones; L Sun; Matthew Bogyo; H J Geuze; Hidde L Ploegh
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol.
Cell 1996;84(5):769-79.
1995: Ann B Hill; P Jugovic; I York; G Russ; J Bennink; jon yewdell; Hidde L Ploegh; David C Johnson
Herpes simplex virus turns off the TAP to evade host immunity.
Nature 1995;375(6530):411-5.
1995: H G Ljunggren; L Van Kaer; M S Sabatine; Hugh Auchincloss; Susumu Tonegawa; Hidde L Ploegh
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice.
International immunology 1995;7(6):975-84.
1995: R P Machold; S Andrée; L Van Kaer; H G Ljunggren; Hidde L Ploegh
Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains.
The Journal of experimental medicine 1995;181(3):1111-22.
1995: H Martien van Santen; A Woolsey; P G Rickardt; L Van Kaer; E J Baas; Anton Berns; Susumu Tonegawa; Hidde L Ploegh
Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene.
The Journal of experimental medicine 1995;181(2):787-92.
1995: Ann B Hill; Hidde L Ploegh
Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):341-3.
1995: Hidde L Ploegh
Trafficking and assembly of MHC molecules: how viruses elude the immune system.
Cold Spring Harbor symposia on quantitative biology 1995;60():263-6.
1995: P R Wolf; Hidde L Ploegh
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway.
Annual review of cell and developmental biology 1995;11():267-306.
1995: H G Ljunggren; L Van Kaer; P G Ashton-Rickardt; Susumu Tonegawa; Hidde L Ploegh
Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice.
European journal of immunology 1995;25(1):174-8.
1995: M T Heemels; Hidde L Ploegh
Generation, translocation, and presentation of MHC class I-restricted peptides.
Annual review of biochemistry 1995;64():463-91.
1994: Schumacher Ton; D V Kantesaria; David V Serreze; Derry C Roopenian; Hidde L Ploegh
Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):13004-8.
1994: M T Heemels; Hidde L Ploegh
Substrate specificity of allelic variants of the TAP peptide transporter.
Immunity 1994;1(9):775-84.
1994: M J Bijlmakers; P Benaroch; Hidde L Ploegh
Mapping functional regions in the lumenal domain of the class II-associated invariant chain.
The Journal of experimental medicine 1994;180(2):623-9.
1994: M J Bijlmakers; P Benaroch; Hidde L Ploegh
Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.
The EMBO journal 1994;13(11):2699-707.
1994: A Tulp; Desiree Verwoerd; Bernhard Dobberstein; Hidde L Ploegh; J Pieters
Isolation and characterization of the intracellular MHC class II compartment.
Nature 1994;369(6476):120-6.
1994: A Tan; L van den Broek; J Bolscher; D J Vermaas; L Pastoors; Constant van Boeckel; Hidde L Ploegh
Introduction of oxygen into the alkyl chain of N-decyl-dNM decreases lipophilicity and results in increased retention of glucose residues on N-linked oligosaccharides.
Glycobiology 1994;4(2):141-9.
1994: Schumacher Ton; D V Kantesaria; M T Heemels; P G Ashton-Rickardt; J C Shepherd; Klaus J Frueh; Y Yang; P A Peterson; Susumu Tonegawa; Hidde L Ploegh
Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.
The Journal of experimental medicine 1994;179(2):533-40.
1993: M T Heemels; Schumacher Ton; K Wonigeit; Hidde L Ploegh
Peptide translocation by variants of the transporter associated with antigen processing.
Science (New York, N.Y.) 1993;262(5142):2059-63.
1993: P G Ashton-Rickardt; L Van Kaer; Schumacher Ton; Hidde L Ploegh; Susumu Tonegawa
Repertoire-determining role of peptide in the positive selection of CD8+ T cells.
Immunological reviews 1993;135():157-82.
1993: Mamadi Yilla; A Tan; K Ito; K Miwa; Hidde L Ploegh
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells.
The Journal of biological chemistry 1993;268(25):19092-100.
1993: J C Shepherd; Schumacher Ton; P G Ashton-Rickardt; S Imaeda; Hidde L Ploegh; C A Janeway; Susumu Tonegawa
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective.
Cell 1993;74(3):577-84.
1993: P G Ashton-Rickardt; L Van Kaer; Schumacher Ton; Hidde L Ploegh; Susumu Tonegawa
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus.
Cell 1993;73(5):1041-9.
1993: M T Heemels; Hidde L Ploegh
Antigen presentation: untapped peptides.
Current biology : CB 1993;3(6):380-3.
1993: M J Bijlmakers; Jacques Neefjes; E H Wojcik-Jacobs; Hidde L Ploegh
The assembly of H2-Kb class I molecules translated in vitro requires oxidized glutathione and peptide.
European journal of immunology 1993;23(6):1305-13.
1993: Jacques Neefjes; J Dierx; Hidde L Ploegh
The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions.
European journal of immunology 1993;23(4):840-5.
1993: L van der Voorn; O Tol; T M Hengeveld; Hidde L Ploegh
Structural and functional studies on the G(o) protein.
The Journal of biological chemistry 1993;268(7):5131-8.
1993: M J Bijlmakers; Hidde L Ploegh
Putting together an MHC class I molecule.
Current opinion in immunology 1993;5(1):21-6.
1993: D Schaap; J van der Wal; Wim J van Blitterswijk; R L van der Bend; Hidde L Ploegh
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
The Biochemical journal 1993;289 ( Pt 3)():875-81.
1993: T Eichholtz; D B de Bont; John de Widt; Rob M J Liskamp; Hidde L Ploegh
A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor.
The Journal of biological chemistry 1993;268(3):1982-6.
1992: L Van Kaer; P G Ashton-Rickardt; Hidde L Ploegh; Susumu Tonegawa
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.
Cell 1992;71(7):1205-14.
1992: T Eichholtz; P Vossebeld; M van Overveld; Hidde L Ploegh
Activation of protein kinase C accelerates internalization of transferrin receptor but not of major histocompatibility complex class I, independent of their phosphorylation status.
The Journal of biological chemistry 1992;267(31):22490-5.
1992: ML De Bruijn; JD Nieland; Schumacher Ton; Hidde L Ploegh; W Martin Kast; Cornelis J M Melief
Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses.
European journal of immunology 1992;22(11):3013-20.
1992: L van der Voorn; T M Hengeveld; Hidde L Ploegh
Subunit interactions of the Go protein.
FEBS letters 1992;308(1):75-8.
1992: L van der Voorn; Hidde L Ploegh
The WD-40 repeat.
FEBS letters 1992;307(2):131-4.
1992: E J Baas; H M van Santen; M J Kleijmeer; H J Geuze; Peter J Peters; Hidde L Ploegh
Peptide-induced stabilization and intracellular localization of empty HLA class I complexes.
The Journal of experimental medicine 1992;176(1):147-56.
1992: K Deres; Schumacher Ton; KH Wiesmüller; S Stevanović; G Greiner; G Jung; Hidde L Ploegh
Preferred size of peptides that bind to H-2 Kb is sequence dependent.
European journal of immunology 1992;22(6):1603-8.
1992: Schumacher Ton; G M Van Bleek; M T Heemels; K Deres; K W Li; M Imarai; L N Vernie; Stanley G Nathenson; Hidde L Ploegh
Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules.
European journal of immunology 1992;22(6):1405-12.
1992: Jacques Neefjes; L Smit; M Gehrmann; Hidde L Ploegh
The fate of the three subunits of major histocompatibility complex class I molecules.
European journal of immunology 1992;22(6):1609-14.
1992: A Tan; J Bolscher; C Feltkamp; Hidde L Ploegh
Retrograde transport from the Golgi region to the endoplasmic reticulum is sensitive to GTP gamma S.
The Journal of cell biology 1992;116(6):1357-67.
1992: G F Verheijden; Wouter H Moolenaar; Hidde L Ploegh
Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells.
The Biochemical journal 1992;282 ( Pt 1)():115-21.
1992: Jacques Neefjes; Hidde L Ploegh
Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.
The EMBO journal 1992;11(2):411-6.
1992: Hidde L Ploegh
MHC products: biosynthesis, intracellular traffic, and "empty" molecules.
Cold Spring Harbor symposia on quantitative biology 1992;57():565-70.
1991: ML De Bruijn; Schumacher Ton; JD Nieland; Hidde L Ploegh; W Martin Kast; Cornelis J M Melief
Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses.
European journal of immunology 1991;21(12):2963-70.
1991: A Tan; L van den Broek; Constant van Boeckel; Hidde L Ploegh; J Bolscher
Chemical modification of the glucosidase inhibitor 1-deoxynojirimycin. Structure-activity relationships.
The Journal of biological chemistry 1991;266(22):14504-10.
1991: Jacques Neefjes; Schumacher Ton; Hidde L Ploegh
Assembly and intracellular transport of major histocompatibility complex molecules.
Current opinion in cell biology 1991;3(4):601-9.
1991: Schumacher Ton; ML De Bruijn; L N Vernie; W Martin Kast; Cornelis J M Melief; Jacques Neefjes; Hidde L Ploegh
Peptide selection by MHC class I molecules.
Nature 1991;350(6320):703-6.
1990: Hidde L Ploegh; Jacques Neefjes
Protein glycosylation.
Current opinion in cell biology 1990;2(6):1125-30.
1990: D Schaap; John de Widt; J van der Wal; J Vandekerckhove; J van Damme; D Gussow; Hidde L Ploegh; Wim J van Blitterswijk; R L van der Bend
Purification, cDNA-cloning and expression of human diacylglycerol kinase.
FEBS letters 1990;275(1-2):151-8.
1990: Jacques Neefjes; T Hengeveld; O Tol; Hidde L Ploegh
Intracellular interactions of transferrin and its receptor during biosynthesis.
The Journal of cell biology 1990;111(4):1383-92.
1990: Schumacher Ton; M T Heemels; Jacques Neefjes; W Martin Kast; Cornelis J M Melief; Hidde L Ploegh
Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro.
Cell 1990;62(3):563-7.
1990: Jacques Neefjes; V Stollorz; Peter J Peters; H J Geuze; Hidde L Ploegh
The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route.
Cell 1990;61(1):171-83.
1990: T Eichholtz; J Alblas; M van Overveld; Wouter H Moolenaar; Hidde L Ploegh
A pseudosubstrate peptide inhibits protein kinase C-mediated phosphorylation in permeabilized Rat-1 cells.
FEBS letters 1990;261(1):147-50.
1990: Jacques Neefjes; ML De Bruijn; C J Boog; JD Nieland; J Boes; Cornelis J M Melief; Hidde L Ploegh
N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response.
The Journal of experimental medicine 1990;171(2):583-8.
1990: N J Stam; T M Vroom; Peter J Peters; E B Pastoors; Hidde L Ploegh
HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy.
International immunology 1990;2(2):113-25.
1989: Jacques Neefjes; J Lindhout; H J Broxterman; G A van der Marel; J H van Boom; Hidde L Ploegh
Non-carrier-mediated uptake of the mannosidase I inhibitor 1-deoxymannojirimycin by K562 erythroleukemic cells.
The Journal of biological chemistry 1989;264(17):10271-5.
1989: N J Stam; W Martin Kast; A C Voordouw; L B Pastoors; F A van der Hoeven; Cornelis J M Melief; Hidde L Ploegh
Lack of correlation between levels of MHC class I antigen and susceptibility to lysis of small cellular lung carcinoma (SCLC) by natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):4113-7.
1989: C J Boog; Jacques Neefjes; J Boes; Hidde L Ploegh; Cornelis J M Melief
Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells.
European journal of immunology 1989;19(3):537-42.
1989: Rob A Gruters; Jero Calafat; C J Vennegoor; H Jansen; Hidde L Ploegh
Structural heterogeneity of a human melanoma-associated antigen.
Cancer research 1989;49(2):459-65.
1988: J G Bolscher; M M van der Bijl; Jacques Neefjes; A Hall; Lou A Smets; Hidde L Ploegh
Ras (proto)oncogene induces N-linked carbohydrate modification: temporal relationship with induction of invasive potential.
The EMBO journal 1988;7(11):3361-8.
1988: Jacques Neefjes; J M Verkerk; H J Broxterman; G A van der Marel; J H van Boom; Hidde L Ploegh
Recycling glycoproteins do not return to the cis-Golgi.
The Journal of cell biology 1988;107(1):79-87.
1988: Jacques Neefjes; Hidde L Ploegh
Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association.
European journal of immunology 1988;18(5):801-10.
1987: Rob A Gruters; Jacques Neefjes; M Tersmette; R E de Goede; A Tulp; H G Huisman; Frank Miedema; Hidde L Ploegh
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Nature 1987;330(6143):74-7.
1987: femia kievits; P Ivanyi; P Krimpenfort; A Berns; Hidde L Ploegh
HLA-restricted recognition of viral antigens in HLA transgenic mice.
Nature 1987;329(6138):447-9.