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Hidde Ploegh

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
25
Tortorella, Domenico
18
Kessler, Benedikt
17
Neefjes, Jacques
15
Spooner, Eric
14
Ovaa, Huib
13
Schumacher, Ton
13
Kim, You-Me
13
Maehr, Rene
12
Boes, Marianne
11
Fiebiger, Edda
11
Galardy, Paul
11
Villadangos, José
10
Schust, Daniel
10
Overkleeft, Herman
10
Lilley, Brendan

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Publications

TOP 3
Ernst Robert; Mueller Britta; Ploegh Hidde L; Schlieker Christian
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
Hu Chih-Chi Andrew; Dougan Stephanie K; Winter Sebastian Virreira; Paton Adrienne W; Paton James C; Ploegh Hidde L
Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes.
Gredmark-Russ Sara; Isaacson Marisa K; Kattenhorn Lisa; Cheung Evelyn J; Watson Nicki; Ploegh Hidde L
A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection.

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All Publications

2009: Ernst Robert; Mueller Britta; Ploegh Hidde L; Schlieker Christian
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
Molecular cell 2009;36(1):28-38.
2009: Hu Chih-Chi Andrew; Dougan Stephanie K; Winter Sebastian Virreira; Paton Adrienne W; Paton James C; Ploegh Hidde L
Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes.
The Journal of experimental medicine 2009;206(11):2429-40.
2009: Gredmark-Russ Sara; Isaacson Marisa K; Kattenhorn Lisa; Cheung Evelyn J; Watson Nicki; Ploegh Hidde L
A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection.
Journal of virology 2009;83(20):10644-52.
2009: McGehee Annette M; Dougan Stephanie K; Klemm Elizabeth J; Shui Guanghou; Park Boyoun; Kim You-Me; Watson Nicki; Wenk Markus R; Ploegh Hidde L; Hu Chih-Chi Andrew
XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3690-9.
2009: Antos John M; Chew Guo-Liang; Guimaraes Carla P; Yoder Nicholas C; Grotenbreg Gijsbert M; Popp Maximilian Wei-Lin; Ploegh Hidde L
Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity.
Journal of the American Chemical Society 2009;131(31):10800-1.
2009: Costantino Cristina Maria; Ploegh Hidde L; Hafler David A
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):945-52.
2009: Isaacson Marisa K; Ploegh Hidde L
Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection.
Cell host & microbe 2009;5(6):559-70.
2009: Hu Chih-Chi Andrew; Dougan Stephanie K; McGehee Annette M; Love J Christopher; Ploegh Hidde L
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.
The EMBO journal 2009;28(11):1624-36.
2009: Antos John M; Popp Maximilian Wei-Lin; Ernst Robert; Chew Guo-Liang; Spooner Eric; Ploegh Hidde L
A straight path to circular proteins.
The Journal of biological chemistry 2009;284(23):16028-36.
2009: Popp Maximilian Wei-Lin; Antos John M; Ploegh Hidde L
Site-specific protein labeling via sortase-mediated transpeptidation.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2009;Chapter 15():Unit 15.3.
2009: Love Kerry Routenberg; Pandya Renuka K; Spooner Eric; Ploegh Hidde L
Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery.
ACS chemical biology 2009;4(4):275-87.
2009: Popp Maximilian W; Artavanis-Tsakonas Katerina; Ploegh Hidde L
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
The Journal of biological chemistry 2009;284(6):3593-602.
2008: Antos John M; Miller Gwenn M; Grotenbreg Gijsbert M; Ploegh Hidde L
Lipid modification of proteins through sortase-catalyzed transpeptidation.
Journal of the American Chemical Society 2008;130(48):16338-43.
2008: Park Boyoun; Brinkmann Melanie M; Spooner Eric; Lee Clarissa C; Kim You-Me; Ploegh Hidde L
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.
Nature immunology 2008;9(12):1407-14.
2008: Gredmark-Russ Sara; Cheung Evelyn J; Isaacson Marisa K; Ploegh Hidde L; Grotenbreg Gijsbert M
The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens.
Journal of virology 2008;82(24):12205-12.
2008: Frickel Eva-Maria; Sahoo Nivedita; Hopp Johnathan; Gubbels Marc-Jan; Craver Mary Patricia J; Knoll Laura J; Ploegh Hidde L; Grotenbreg Gijsbert M
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes.
The Journal of infectious diseases 2008;198(11):1625-33.
2008: Schlieker Christian D; Van der Veen Annemarthe G; Damon Jadyn R; Spooner Eric; Ploegh Hidde L
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18255-60.
2008: Story Craig M; Papa Eliseo; Hu Chih-Chi Andrew; Ronan Jehnna L; Herlihy Kara; Ploegh Hidde L; Love J Christopher
Profiling antibody responses by multiparametric analysis of primary B cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17902-7.
2008: Bradshaw Elizabeth M; Kent Sally C; Tripuraneni Vinay; Orban Tihamer; Ploegh Hidde L; Hafler David A; Love J Christopher
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.
Clinical immunology (Orlando, Fla.) 2008;129(1):10-8.
2008: Mueller Britta; Klemm Elizabeth J; Spooner Eric; Claessen Jasper H; Ploegh Hidde L
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12325-30.
2008: Vyas Jatin M; Van der Veen Annemarthe G; Ploegh Hidde L
The known unknowns of antigen processing and presentation.
Nature reviews. Immunology 2008;8(8):607-18.
2008: Kim You-Me; Brinkmann Melanie M; Paquet Marie-Eve; Ploegh Hidde L
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.
Nature 2008;452(7184):234-8.
2008: Costantino Cristina M; Hang Howard C; Kent Sally C; Hafler David A; Ploegh Hidde L
Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2876-85.
2008: Grotenbreg Gijsbert M; Roan Nadia R; Guillen Eduardo; Meijers Rob; Wang Jia-Huai; Bell George W; Starnbach Michael N; Ploegh Hidde L
Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3831-6.
2008: Kario Edith; Tirosh Boaz; Ploegh Hidde L; Navon Ami
N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation.
The Journal of biological chemistry 2008;283(1):244-54.
2007: Jarosinski Keith; Kattenhorn Lisa; Kaufer Benedikt; Ploegh Hidde; Osterrieder Nikolaus
A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):20025-30.
2007: Ploegh Hidde L
Bridging B cell and T cell recognition of antigen.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7193.
2007: Ploegh Hidde
Hidde Ploegh: immunologist, journeyman. Interview by Nicole LeBrasseur.
The Journal of cell biology 2007;179(3):364-5.
2007: Love Kerry Routenberg; Catic André; Schlieker Christian; Ploegh Hidde L
Mechanisms, biology and inhibitors of deubiquitinating enzymes.
Nature chemical biology 2007;3(11):697-705.
2007: Popp Maximilian W; Antos John M; Grotenbreg Gijsbert M; Spooner Eric; Ploegh Hidde L
Sortagging: a versatile method for protein labeling.
Nature chemical biology 2007;3(11):707-8.
2007: Ploegh Hidde L
The peptide cargo of class I molecules: not just passive passengers.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4299-300.
2007: Derkow Katja; Loddenkemper Christoph; Mintern Justine; Kruse Nils; Klugewitz Katja; Berg Thomas; Wiedenmann Bertram; Ploegh Hidde L; Schott Eckart
Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis.
Hepatology (Baltimore, Md.) 2007;46(4):1155-65.
2007: Gredmark Sara; Schlieker Christian; Quesada Victor; Spooner Eric; Ploegh Hidde L
A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.
Journal of virology 2007;81(19):10300-9.
2007: Ploegh Hidde L
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.
Nature 2007;448(7152):435-8.
2007: Catic André; Sun Zhen-Yu J; Ratner Daniel M; Misaghi Shahram; Spooner Eric; Samuelson John; Wagner Gerhard; Ploegh Hidde L
Sequence and structure evolved separately in a ribosomal ubiquitin variant.
The EMBO journal 2007;26(14):3474-83.
2007: Kim You-Me; Brinkmann Melanie M; Ploegh Hidde L
TLRs bent into shape.
Nature immunology 2007;8(7):675-7.
2007: Grotenbreg Gijsbert M; Nicholson Melissa J; Fowler Kevin D; Wilbuer Kathrin; Octavio Leah; Yang Maxine; Chakraborty Arup K; Ploegh Hidde L; Wucherpfennig Kai W
Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.
The Journal of biological chemistry 2007;282(29):21425-36.
2007: Vyas Jatin M; Kim You-Me; Artavanis-Tsakonas Katerina; Love J Christopher; Van der Veen Annemarthe G; Ploegh Hidde L
Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7199-210.
2007: Ryu Kwon-Yul; Maehr René; Gilchrist Catherine A; Long Michael A; Bouley Donna M; Mueller Britta; Ploegh Hidde L; Kopito Ron R
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.
The EMBO journal 2007;26(11):2693-706.
2007: Frickel Eva-Maria; Quesada Víctor; Muething Larissa; Gubbels Marc-Jan; Spooner Eric; Ploegh Hidde; Artavanis-Tsakonas Katerina
Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution.
Cellular microbiology 2007;9(6):1601-10.
2007: Grotenbreg Gijsbert; Ploegh Hidde
Chemical biology: dressed-up proteins.
Nature 2007;446(7139):993-5.
2007: Brinkmann Melanie M; Spooner Eric; Hoebe Kasper; Beutler Bruce; Ploegh Hidde L; Kim You-Me
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.
The Journal of cell biology 2007;177(2):265-75.
2007: Gavanescu Irina; Kessler Benedikt; Ploegh Hidde; Benoist Christophe; Mathis Diane
Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4583-7.
2007: Schlieker Christian; Weihofen Wilhelm A; Frijns Evelyne; Kattenhorn Lisa M; Gaudet Rachelle; Ploegh Hidde L
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.
Molecular cell 2007;25(5):677-87.
2007: Hang Howard C; Geutjes Ernst-Jan; Grotenbreg Gijsbert; Pollington Annette M; Bijlmakers Marie Jose; Ploegh Hidde L
Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells.
Journal of the American Chemical Society 2007;129(10):2744-5.
2007: Kumazaki Kaori; Tirosh Boaz; Maehr René; Boes Marianne; Honjo Tasuku; Ploegh Hidde L
AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2192-203.
2007: Catic André; Fiebiger Edda; Korbel Gregory A; Blom Daniël; Galardy Paul J; Ploegh Hidde L
Screen for ISG15-crossreactive deubiquitinases.
PloS one 2007;2(7):e679.
2007: Catic André; Misaghi Shahram; Korbel Gregory A; Ploegh Hidde L
ElaD, a Deubiquitinating protease expressed by E. coli.
PloS one 2007;2(4):e381.
2006: Hang Howard C; Loureiro Joana; Spooner Eric; van der Velden Adrianus W M; Kim You-Me; Pollington Annette M; Maehr Rene; Starnbach Michael N; Ploegh Hidde L
Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.
ACS chemical biology 2006;1(11):713-23.
2006: Mintern Justine D; Klemm Elizabeth J; Wagner Markus; Paquet Marie Eve; Napier Melanie D; Kim You Me; Koszinowski Ulrich H; Ploegh Hidde L
Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8422-31.
2006: Vishwanath Mridula; Nishibu Akiko; Saeland Sem; Ward Brant R; Mizumoto Norikatsu; Ploegh Hidde L; Boes Marianne; Takashima Akira
Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover.
The Journal of investigative dermatology 2006;126(11):2452-7.
2006: Artavanis-Tsakonas Katerina; Love J Christopher; Ploegh Hidde L; Vyas Jatin M
Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):15945-50.
2006: Mueller Britta; Lilley Brendan N; Ploegh Hidde L
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.
The Journal of cell biology 2006;175(2):261-70.
2006: Artavanis-Tsakonas Katerina; Misaghi Shahram; Comeaux Christy A; Catic Andre; Spooner Eric; Duraisingh Manoj T; Ploegh Hidde L
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.
Molecular microbiology 2006;61(5):1187-95.
2006: Lilley Brendan N; Gilbert Joanna M; Ploegh Hidde L; Benjamin Thomas L
Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection.
Journal of virology 2006;80(17):8739-44.
2006: Koch Katherine S; Son Kyung-Hwa; Maehr Rene; Pellicciotta Illenia; Ploegh Hidde L; Zanetti Maurizio; Sell Stewart; Leffert Hyam L
Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines.
Immunology 2006;119(1):98-115.
2006: Patterson Heide Christine K; Kraus Manfred; Kim You-Me; Ploegh Hidde; Rajewsky Klaus
The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain.
Immunity 2006;25(1):55-65.
2006: Shringarpure Reshma; Catley Laurence; Bhole Deepak; Burger Renate; Podar Klaus; Tai Yu-Tzu; Kessler Benedikt; Galardy Paul; Ploegh Hidde; Tassone Pierfrancesco; Hideshima Teru; Mitsiades Constantine; Munshi Nikhil C; Chauhan Dharminder; Anderson Kenneth C
Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib.
British journal of haematology 2006;134(2):145-56.
2006: Misaghi Shahram; Balsara Zarine R; Catic Andre; Spooner Eric; Ploegh Hidde L; Starnbach Michael N
Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection.
Molecular microbiology 2006;61(1):142-50.
2006: Loureiro Joana; Lilley Brendan N; Spooner Eric; Noriega Vanessa; Tortorella Domenico; Ploegh Hidde L
Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.
Nature 2006;441(7095):894-7.
2006: Di Bacco Alessandra; Ouyang Jian; Lee Hsiang-Ying; Catic Andre; Ploegh Hidde; Gill Grace
The SUMO-specific protease SENP5 is required for cell division.
Molecular and cellular biology 2006;26(12):4489-98.
2006: Wang Jianlei; Loveland Amy N; Kattenhorn Lisa M; Ploegh Hidde L; Gibson Wade
High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable.
Journal of virology 2006;80(12):6003-12.
2006: Love J Christopher; Ronan Jehnna L; Grotenbreg Gijsbert M; van der Veen Annemarthe G; Ploegh Hidde L
A microengraving method for rapid selection of single cells producing antigen-specific antibodies.
Nature biotechnology 2006;24(6):703-7.
2006: Huang Tony T; Nijman Sebastian M B; Mirchandani Kanchan D; Galardy Paul J; Cohn Martin A; Haas Wilhelm; Gygi Steven P; Ploegh Hidde L; Bernards René; D'Andrea Alan D
Regulation of monoubiquitinated PCNA by DUB autocleavage.
Nature cell biology 2006;8(4):339-47.
2006: Nishibu Akiko; Ward Brant R; Jester James V; Ploegh Hidde L; Boes Marianne; Takashima Akira
Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli.
The Journal of investigative dermatology 2006;126(4):787-96.
2006: Groll Michael; Berkers Celia R; Ploegh Hidde L; Ovaa Huib
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.
Structure (London, England : 1993) 2006;14(3):451-6.
2006: Tirosh Boaz; Iwakoshi Neal N; Glimcher Laurie H; Ploegh Hidde L
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response.
The Journal of biological chemistry 2006;281(9):5852-60.
2006: Kim You-Me; Pan Jennifer Yi-Jiun; Korbel Gregory A; Peperzak Victor; Boes Marianne; Ploegh Hidde L
Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3327-32.
2006: Misaghi S; Korbel G A; Kessler B; Spooner E; Ploegh H L
z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress.
Cell death and differentiation 2006;13(1):163-5.
2006: Loureiro Joana; Ploegh Hidde L
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.
Advances in immunology 2006;92():225-305.
2005: Schlieker Christian; Korbel Gregory A; Kattenhorn Lisa M; Ploegh Hidde L
A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae.
Journal of virology 2005;79(24):15582-5.
2005: Anderson Christopher; Crimmins Stephen; Wilson Julie A; Korbel Greg A; Ploegh Hidde L; Wilson Scott M
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice.
Journal of neurochemistry 2005;95(3):724-31.
2005: Catic André; Ploegh Hidde L
Ubiquitin--conserved protein or selfish gene?
Trends in biochemical sciences 2005;30(11):600-4.
2005: Lilley Brendan N; Ploegh Hidde L
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14296-301.
2005: Maehr René; Mintern Justine D; Herman Ann E; Lennon-Duménil Ana-Maria; Mathis Diane; Benoist Christophe; Ploegh Hidde L
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.
The Journal of clinical investigation 2005;115(10):2934-43.
2005: Lilley Brendan N; Ploegh Hidde L
Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond.
Immunological reviews 2005;207():126-44.
2005: Altun Mikael; Galardy Paul J; Shringarpure Reshma; Hideshima Teru; LeBlanc Richard; Anderson Kenneth C; Ploegh Hidde L; Kessler Benedikt M
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells.
Cancer research 2005;65(17):7896-901.
2005: Boes Marianne; van der Wel Nicole; Peperzak Victor; Kim You-Me; Peters Peter J; Ploegh Hidde
In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S.
European journal of immunology 2005;35(9):2552-62.
2005: Kattenhorn Lisa M; Korbel Gregory A; Kessler Benedikt M; Spooner Eric; Ploegh Hidde L
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae.
Molecular cell 2005;19(4):547-57.
2005: Tirosh Boaz; Iwakoshi Neal N; Glimcher Laurie H; Ploegh Hidde L
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells.
The Journal of experimental medicine 2005;202(4):505-16.
2005: Ploegh Hidde L
A molecule's right to choose: how diabetogenic class II MHC products bind peptides.
The Journal of clinical investigation 2005;115(8):2077-9.
2005: Tseng Huang-Chun; Ovaa Huib; Wei Nancy J C; Ploegh Hidde; Tsai Li-Huei
Phosphoproteomic analysis with a solid-phase capture-release-tag approach.
Chemistry & biology 2005;12(7):769-77.
2005: Guerra Lina; Teter Ken; Lilley Brendan N; Stenerlöw Bo; Holmes Randall K; Ploegh Hidde L; Sandvig Kirsten; Thelestam Monica; Frisan Teresa
Cellular internalization of cytolethal distending toxin: a new end to a known pathway.
Cellular microbiology 2005;7(7):921-34.
2005: Maehr René; Hang Howard C; Mintern Justine D; Kim You-Me; Cuvillier Armelle; Nishimura Mikio; Yamada Kenji; Shirahama-Noda Kanae; Hara-Nishimura Ikuko; Ploegh Hidde L
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7066-74.
2005: Ausubel Lara J; O'Connor Kevin C; Baecher-Allen Clare; Trollmo Christina; Kessler Benedikt; Hekking Brian; Merritt David; Meyer Abbie L; Kwok Bill; Ploegh Hidde; Huber Brigitte T; Hafler David A
Characterization of in vivo expanded OspA-specific human T-cell clones.
Clinical immunology (Orlando, Fla.) 2005;115(3):313-22.
2005: Berkers Celia R; Verdoes Martijn; Lichtman Eben; Fiebiger Edda; Kessler Benedikt M; Anderson Kenneth C; Ploegh Hidde L; Ovaa Huib; Galardy Paul J
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib.
Nature methods 2005;2(5):357-62.
2005: Tirosh Boaz; Iwakoshi Neal N; Lilley Brendan N; Lee Ann-Hwee; Glimcher Laurie H; Ploegh Hidde L
Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products.
Journal of virology 2005;79(5):2768-79.
2005: Borodovsky Anna; Ovaa Huib; Meester Wim J N; Venanzi Emily S; Bogyo Matthew S; Hekking Brian G; Ploegh Hidde L; Kessler Benedikt M; Overkleeft Herman S
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases.
Chembiochem : a European journal of chemical biology 2005;6(2):287-91.
2005: Niess Jan Hendrik; Brand Stephan; Gu Xiubin; Landsman Limor; Jung Steffen; McCormick Beth A; Vyas Jatin M; Boes Marianne; Ploegh Hidde L; Fox James G; Littman Dan R; Reinecker Hans-Christian
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.
Science (New York, N.Y.) 2005;307(5707):254-8.
2005: Fiebiger Edda; Tortorella Domenico; Jouvin Marie-Helene; Kinet Jean-Pierre; Ploegh Hidde L
Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors.
The Journal of experimental medicine 2005;201(2):267-77.
2005: Misaghi Shahram; Galardy Paul J; Meester Wim J N; Ovaa Huib; Ploegh Hidde L; Gaudet Rachelle
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate.
The Journal of biological chemistry 2005;280(2):1512-20.
2005: Ovaa Huib; Galardy Paul J; Ploegh Hidde L
Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: synthesis of active site-directed probes.
Methods in enzymology 2005;399():468-78.
2005: Galardy Paul; Ploegh Hidde L; Ovaa Huib
Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification.
Methods in enzymology 2005;399():120-31.
2004: Misaghi Shahram; Pacold Michael E; Blom Daniël; Ploegh Hidde L; Korbel Gregory Alan
Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover.
Chemistry & biology 2004;11(12):1677-87.
2004: Catic André; Collins Cal; Church George M; Ploegh Hidde L
Preferred in vivo ubiquitination sites.
Bioinformatics (Oxford, England) 2004;20(18):3302-7.
2004: Hang Howard C; Ploegh Hidde
Catching proteases in action with microarrays.
Chemistry & biology 2004;11(10):1328-30.
2004: van der Marel Gijs; Ploegh Hidde
Obituary: Jacques H. van Boom (1937-2004).
Nature 2004;431(7010):755.
2004: Kattenhorn Lisa M; Mills Ryan; Wagner Markus; Lomsadze Alexandre; Makeev Vsevolod; Borodovsky Mark; Ploegh Hidde L; Kessler Benedikt M
Identification of proteins associated with murine cytomegalovirus virions.
Journal of virology 2004;78(20):11187-97.
2004: Röhn Till A; Boes Marianne; Wolters Dirk; Spindeldreher Sebastian; Müller Bernd; Langen Hanno; Ploegh Hidde; Vogt Anne B; Kropshofer Harald
Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.
Nature immunology 2004;5(9):909-18.
2004: Maehr René; Kraus Manfred; Ploegh Hidde L
Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment.
European journal of immunology 2004;34(8):2230-6.
2004: Harrison Stephen C; Alberts Bruce; Ehrenfeld Ellie; Enquist Lynn; Fineberg Harvey; McKnight Steven L; Moss Bernard; O'Donnell Michael; Ploegh Hidde; Schmid Sandra L; Walter K Peter; Theriot Julie
Discovery of antivirals against smallpox.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(31):11178-92.
2004: Boes Marianne; Ploegh Hidde L
Translating cell biology in vitro to immunity in vivo.
Nature 2004;430(6996):264-71.
2004: Lilley Brendan N; Ploegh Hidde L
A membrane protein required for dislocation of misfolded proteins from the ER.
Nature 2004;429(6994):834-40.
2004: van Swieten Paul F; Maehr Rene; van den Nieuwendijk Adrianus M C H; Kessler Benedikt M; Reich Michael; Wong Chung-Sing; Kalbacher Hubert; Leeuwenburgh Michiel A; Driessen Christoph; van der Marel Gijsbert A; Ploegh Hidde L; Overkleeft Herman S
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.
Bioorganic & medicinal chemistry letters 2004;14(12):3131-4.
2004: Ploegh Hidde L
Immunology. Nothing 'gainst time's scythe can make defense...
Science (New York, N.Y.) 2004;304(5675):1262-3.
2004: Boes Marianne; Cuvillier Armelle; Ploegh Hidde
Membrane specializations and endosome maturation in dendritic cells and B cells.
Trends in cell biology 2004;14(4):175-83.
2004: Fiebiger Edda; Hirsch Christian; Vyas Jatin M; Gordon Eva; Ploegh Hidde L; Tortorella Domenico
Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin.
Molecular biology of the cell 2004;15(4):1635-46.
2004: Hemelaar Joris; Galardy Paul J; Borodovsky Anna; Kessler Benedikt M; Ploegh Hidde L; Ovaa Huib
Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases.
Journal of proteome research 2004;3(2):268-76.
2004: Schmidt-Supprian Marc; Tian Jane; Grant Ethan P; Pasparakis Manolis; Maehr René; Ovaa Huib; Ploegh Hidde L; Coyle Anthony J; Rajewsky Klaus
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4566-71.
2004: Cohen Haim Y; Lavu Siva; Bitterman Kevin J; Hekking Brian; Imahiyerobo Thomas A; Miller Christine; Frye Roy; Ploegh Hidde; Kessler Benedikt M; Sinclair David A
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
Molecular cell 2004;13(5):627-38.
2004: Palliser Deborah; Ploegh Hidde; Boes Marianne
Myeloid differentiation factor 88 is required for cross-priming in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3415-21.
2004: Evans Paul C; Ovaa Huib; Hamon Maureen; Kilshaw Peter J; Hamm Svetlana; Bauer Stefan; Ploegh Hidde L; Smith Trevor S
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.
The Biochemical journal 2004;378(Pt 3):727-34.
2004: Ovaa Huib; Kessler Benedikt M; Rolén Ulrika; Galardy Paul J; Ploegh Hidde L; Masucci Maria G
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2253-8.
2004: Gil-Torregrosa Beatriz C; Lennon-Duménil Ana Maria; Kessler Benedikt; Guermonprez Pierre; Ploegh Hidde L; Fruci Doriana; van Endert Peter; Amigorena Sebastian
Control of cross-presentation during dendritic cell maturation.
European journal of immunology 2004;34(2):398-407.
2004: Blom Daniël; Hirsch Christian; Stern Patrick; Tortorella Domenico; Ploegh Hidde L
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised.
The EMBO journal 2004;23(3):650-8.
2004: Bryant Paula; Ploegh Hidde
Class II MHC peptide loading by the professionals.
Current opinion in immunology 2004;16(1):96-102.
2004: Hirsch Christian; Misaghi Shahram; Blom Daniël; Pacold Michael E; Ploegh Hidde L
Yeast N-glycanase distinguishes between native and non-native glycoproteins.
EMBO reports 2004;5(2):201-6.
2004: Mintern Justine D; Maurice Madelon M; Ploegh Hidde L; Schott Eckart
Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):699-708.
2004: Grovender Eric A; Kellogg Brenda; Singh Jasleen; Blom Daniel; Ploegh Hidde; Wittrup K Dane; Langer Robert S; Ameer Guillermo A
Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin.
Kidney international 2004;65(1):310-22.
2004: Hemelaar Joris; Borodovsky Anna; Kessler Benedikt M; Reverter David; Cook Julie; Kolli Nagamallesawari; Gan-Erdene Tudev; Wilkinson Keith D; Gill Grace; Lima Christopher D; Ploegh Hidde L; Ovaa Huib
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.
Molecular and cellular biology 2004;24(1):84-95.
2004: Misaghi Shahram; Sun Zhen-Yu J; Stern Patrick; Gaudet Rachelle; Wagner Gerhard; Ploegh Hidde
Structural and functional analysis of human cytomegalovirus US3 protein.
Journal of virology 2004;78(1):413-23.
2003: Pieters Jean; Ploegh Hidde
Microbiology. Chemical warfare and mycobacterial defense.
Science (New York, N.Y.) 2003;302(5652):1900-2.
2003: Bertho Nicolas; Cerny Jan; Kim You-Me; Fiebiger Edda; Ploegh Hidde; Boes Marianne
Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5689-96.
2003: Hudson Amy W; Blom Daniël; Howley Peter M; Ploegh Hidde L
The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes.
Traffic (Copenhagen, Denmark) 2003;4(12):824-37.
2003: Hemelaar Joris; Lelyveld Victor S; Kessler Benedikt M; Ploegh Hidde L
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L.
The Journal of biological chemistry 2003;278(51):51841-50.
2003: Kocks Christine; Maehr Rene; Overkleeft Herman S; Wang Evelyn W; Iyer Lackshmanan K; Lennon-Dumenil Ana-Maria; Ploegh Hidde L; Kessler Benedikt M
Functional proteomics of the active cysteine protease content in Drosophila S2 cells.
Molecular & cellular proteomics : MCP 2003;2(11):1188-97.
2003: Schott Eckart; Bonasio Roberto; Ploegh Hidde L
Elimination in vivo of developing T cells by natural killer cells.
The Journal of experimental medicine 2003;198(8):1213-24.
2003: Boes Marianne; Bertho Nicolas; Cerny Jan; Op den Brouw Marjolein; Kirchhausen Tomas; Ploegh Hidde
T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4081-8.
2003: Lilley Brendan N; Tortorella Domenico; Ploegh Hidde L
Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer.
Molecular biology of the cell 2003;14(9):3690-8.
2003: Furman Margo H; Loureiro Joana; Ploegh Hidde L; Tortorella Domenico
Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum.
The Journal of biological chemistry 2003;278(37):34804-11.
2003: Kisselev Alexei F; Garcia-Calvo Margarita; Overkleeft Herman S; Peterson Erin; Pennington Michael W; Ploegh Hidde L; Thornberry Nancy A; Goldberg Alfred L
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.
The Journal of biological chemistry 2003;278(38):35869-77.
2003: Ovaa Huib; van Swieten Paul F; Kessler Benedikt M; Leeuwenburgh Michiel A; Fiebiger Edda; van den Nieuwendijk Adrianus M C H; Galardy Paul J; van der Marel Gijsbert A; Ploegh Hidde L; Overkleeft Herman S
Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy.
Angewandte Chemie (International ed. in English) 2003;42(31):3626-9.
2003: D'Orazio S E; Halme D G; Ploegh H L; Starnbach M N
Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):291-8.
2003: Hirsch Christian; Blom Daniël; Ploegh Hidde L
A role for N-glycanase in the cytosolic turnover of glycoproteins.
The EMBO journal 2003;22(5):1036-46.
2003: Kessler Benedikt; Hong Xu; Petrovic Jelena; Borodovsky Anna; Dantuma Nico P; Bogyo Matthew; Overkleeft Herman S; Ploegh Hidde; Glas Rickard
Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production.
The Journal of biological chemistry 2003;278(12):10013-21.
2003: Tirosh Boaz; Furman Margo H; Tortorella Domenico; Ploegh Hidde L
Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation.
The Journal of biological chemistry 2003;278(9):6664-72.
2002: Kalka-Moll Wiltrud M; Tzianabos Arthur O; Bryant Paula W; Niemeyer Marcus; Ploegh Hidde L; Kasper Dennis L
Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6149-53.
2002: Schott Eckart; Ploegh Hidde L
Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells.
European journal of immunology 2002;32(12):3425-34.
2002: Fiebiger Edda; Maehr René; Villadangos José; Weber Ekkehard; Erickson Ann; Bikoff Elizabeth; Ploegh Hidde L; Lennon-Duménil Ana-Maria
Invariant chain controls the activity of extracellular cathepsin L.
The Journal of experimental medicine 2002;196(9):1263-9.
2002: Vugmeyster Yulia; Borodovsky Anna; Maurice Madelon M; Maehr René; Furman Margo H; Ploegh Hidde L
The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP).
Molecular immunology 2002;39(7-8):431-41.
2002: Furman Margo H; Dey Neelendu; Tortorella Domenico; Ploegh Hidde L
The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules.
Journal of virology 2002;76(22):11753-6.
2002: Borodovsky Anna; Ovaa Huib; Kolli Nagamalleswari; Gan-Erdene Tudeviin; Wilkinson Keith D; Ploegh Hidde L; Kessler Benedikt M
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.
Chemistry & biology 2002;9(10):1149-59.
2002: Schott Eckart; Bertho Nicolas; Ge Qing; Maurice Madelon M; Ploegh Hidde L
Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13735-40.
2002: Furman Margo H; Ploegh Hidde L
Lessons from viral manipulation of protein disposal pathways.
The Journal of clinical investigation 2002;110(7):875-9.
2002: Kessler Benedikt M; Glas Rickard; Ploegh Hidde L
MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation.
Molecular immunology 2002;39(3-4):171-9.
2002: Leggett David S; Hanna John; Borodovsky Anna; Crosas Bernat; Schmidt Marion; Baker Rohan T; Walz Thomas; Ploegh Hidde; Finley Daniel
Multiple associated proteins regulate proteasome structure and function.
Molecular cell 2002;10(3):495-507.
2002: Boes Marianne; Cerny Jan; Massol Ramiro; Op den Brouw Marjolein; Kirchhausen Tom; Chen Jianzhu; Ploegh Hidde L
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.
Nature 2002;418(6901):983-8.
2002: Lennon-Duménil Ana-Maria; Bakker Arnold H; Maehr René; Fiebiger Edda; Overkleeft Herman S; Rosemblatt Mario; Ploegh Hidde L; Lagaudrière-Gesbert Cécile
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.
The Journal of experimental medicine 2002;196(4):529-40.
2002: Tirabassi Rebecca S; Ploegh Hidde L
The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products.
Journal of virology 2002;76(13):6832-5.
2002: Felbor Ute; Kessler Benedikt; Mothes Walther; Goebel Hans H; Ploegh Hidde L; Bronson Roderick T; Olsen Bjorn R
Neuronal loss and brain atrophy in mice lacking cathepsins B and L.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):7883-8.
2002: Lorenzo Mayra E; Jung Jae U; Ploegh Hidde L
Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments.
Journal of virology 2002;76(11):5522-31.
2002: Rehm Armin; Engelsberg Arne; Tortorella Domenico; Körner Ida J; Lehmann Insa; Ploegh Hidde L; Höpken Uta E
Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
Journal of virology 2002;76(10):5043-50.
2002: Fiebiger Edda; Story Craig; Ploegh Hidde L; Tortorella Domenico
Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein.
The EMBO journal 2002;21(5):1041-53.
2002: Gewurz Benjamin E; Ploegh Hidde L; Tortorella Domenico
US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide.
The Journal of biological chemistry 2002;277(13):11306-13.
2002: Lagaudrière-Gesbert Cécile; Newmyer Sherri L; Gregers Tone F; Bakke Oddmund; Ploegh Hidde L
Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1515-20.
2002: Plüger Esther B E; Boes Marianne; Alfonso Christopher; Schröter Christian J; Kalbacher Hubert; Ploegh Hidde L; Driessen Christoph
Specific role for cathepsin S in the generation of antigenic peptides in vivo.
European journal of immunology 2002;32(2):467-76.
2002: Lennon-Duménil Ana-Maria; Bakker Arnold H; Wolf-Bryant Paula; Ploegh Hidde L; Lagaudrière-Gesbert Cécile
A closer look at proteolysis and MHC-class-II-restricted antigen presentation.
Current opinion in immunology 2002;14(1):15-21.
2002: Furman Margo H; Ploegh Hidde L; Tortorella Domenico
Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules.
The Journal of biological chemistry 2002;277(5):3258-67.
2002: Ploegh Hidde L
Don Craig Wiley (1944-2001).
Nature 2002;415(6871):492.
2002: Hudson Amy W; Ploegh Hidde L
The cell biology of antigen presentation.
Experimental cell research 2002;272(1):1-7.
2002: Bryant Paula Wolf; Lennon-Duménil Ana-Maria; Fiebiger Edda; Lagaudrière-Gesbert Cécile; Ploegh Hidde L
Proteolysis and antigen presentation by MHC class II molecules.
Advances in immunology 2002;80():71-114.
2001: Riese R J; Shi G P; Villadangos J; Stetson D; Driessen C; Lennon-Dumenil A M; Chu C L; Naumov Y; Behar S M; Ploegh H; Locksley R; Chapman H A
Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.
Immunity 2001;15(6):909-19.
2001: Hudson A W; Howley P M; Ploegh H L
A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes.
Journal of virology 2001;75(24):12347-58.
2001: Lilley B N; Ploegh H L; Tirabassi R S
Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein.
Journal of virology 2001;75(22):11218-21.
2001: Gould D S; Ploegh H L; Schust D J
Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells.
Journal of reproductive immunology 2001;52(1-2):85-99.
2001: Borodovsky A; Kessler B M; Casagrande R; Overkleeft H S; Wilkinson K D; Ploegh H L
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.
The EMBO journal 2001;20(18):5187-96.
2001: Kessler B M; Tortorella D; Altun M; Kisselev A F; Fiebiger E; Hekking B G; Ploegh H L; Overkleeft H S
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.
Chemistry & biology 2001;8(9):913-29.
2001: Shamu C E; Flierman D; Ploegh H L; Rapoport T A; Chau V
Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol.
Molecular biology of the cell 2001;12(8):2546-55.
2001: Gewurz B E; Gaudet R; Tortorella D; Wang E W; Ploegh H L
Virus subversion of immunity: a structural perspective.
Current opinion in immunology 2001;13(4):442-50.
2001: Lennon-Duménil A M; Roberts R A; Valentijn K; Driessen C; Overkleeft H S; Erickson A; Peters P J; Bikoff E; Ploegh H L; Wolf Bryant P
The p41 isoform of invariant chain is a chaperone for cathepsin L.
The EMBO journal 2001;20(15):4055-64.
2001: Maurice M M; Gould D S; Carroll J; Vugmeyster Y; Ploegh H L
Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7437-42.
2001: Gewurz B E; Gaudet R; Tortorella D; Wang E W; Ploegh H L; Wiley D C
Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6794-9.
2001: Gewurz B E; Wang E W; Tortorella D; Schust D J; Ploegh H L
Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner.
Journal of virology 2001;75(11):5197-204.
2001: Ploegh H L
One-dimensional isoelectric focusing of proteins in slab gels.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.2.
2001: Driessen C; Lennon-Duménil A M; Ploegh H L
Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors.
European journal of immunology 2001;31(5):1592-601.
2001: Rehm A; Stern P; Ploegh H L; Tortorella D
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.
The EMBO journal 2001;20(7):1573-82.
2001: Ameer G A; Grovender E A; Ploegh H; Ting D; Owen W F; Rupnick M; Langer R
A novel immunoadsorption device for removing beta2-microglobulin from whole blood.
Kidney international 2001;59(4):1544-50.
2001: Lorenzo M E; Ploegh H L; Tirabassi R S
Viral immune evasion strategies and the underlying cell biology.
Seminars in immunology 2001;13(1):1-9.
2000: Furman M H; Ploegh H L; Schust D J
Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface?
Human immunology 2000;61(11):1169-76.
2000: Das G; Gould D S; Augustine M M; Fragoso G; Sciutto E; Stroynowski I; Van Kaer L; Schust D J; Ploegh H; Janeway C A;
Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes.
The Journal of experimental medicine 2000;192(10):1521-8.
2000: Wang E W; Kessler B M; Borodovsky A; Cravatt B F; Bogyo M; Ploegh H L; Glas R
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):9990-5.
2000: Hirsch C; Ploegh H L
Intracellular targeting of the proteasome.
Trends in cell biology 2000;10(7):268-72.
2000: Tortorella D; Gewurz B; Schust D; Furman M; Ploegh H
Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology.
Immunological investigations 2000;29(2):97-100.
2000: Casagrande R; Stern P; Diehn M; Shamu C; Osario M; Zúñiga M; Brown P O; Ploegh H
Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway.
Molecular cell 2000;5(4):729-35.
2000: Shi G P; Bryant R A; Riese R; Verhelst S; Driessen C; Li Z; Bromme D; Ploegh H L; Chapman H A
Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.
The Journal of experimental medicine 2000;191(7):1177-86.
2000: Felbor U; Dreier L; Bryant R A; Ploegh H L; Olsen B R; Mothes W
Secreted cathepsin L generates endostatin from collagen XVIII.
The EMBO journal 2000;19(6):1187-94.
2000: Villadangos J A; Driessen C; Shi G P; Chapman H A; Ploegh H L
Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.
The EMBO journal 2000;19(5):882-91.
2000: Tortorella D; Gewurz B E; Furman M H; Schust D J; Ploegh H L
Viral subversion of the immune system.
Annual review of immunology 2000;18():861-926.
1999: Villadangos J A; Bryant R A; Deussing J; Driessen C; Lennon-Duménil A M; Riese R J; Roth W; Saftig P; Shi G P; Chapman H A; Peters C; Ploegh H L
Proteases involved in MHC class II antigen presentation.
Immunological reviews 1999;172():109-20.
1999: Driessen C; Bryant R A; Lennon-Duménil A M; Villadangos J A; Bryant P W; Shi G P; Chapman H A; Ploegh H L
Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.
The Journal of cell biology 1999;147(4):775-90.
1999: Taurog J D; Lindahl K F; Hammer R E; Slaughter C A; Maika S D; Zhou M; Roopenian D C; Christianson G J; Gaskell S J; Jones R C; Bordoli R; Ploegh H L; Galocha B; Summerfield S G
A new MHC locus that influences class I peptide presentation.
Immunity 1999;11(4):following 506.
1999: Shamu C E; Story C M; Rapoport T A; Ploegh H L
The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate.
The Journal of cell biology 1999;147(1):45-58.
1999: Bryant P W; Roos P; Ploegh H L; Sant A J
Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties.
European journal of immunology 1999;29(9):2729-39.
1999: Schust D J; Tortorella D; Ploegh H L
Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens.
Journal of reproductive immunology 1999;43(2):243-51.
1999: Story C M; Furman M H; Ploegh H L
The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8516-21.
1999: Rodgers J R; Levitt J M; Cresswell P; Lindahl K F; Mathis D; Monaco J T; Singer D S; Ploegh H L; Bryant P W
A nomenclature solution to mouse MHC confusion.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6294.
1999: Schust D J; Tortorella D; Ploegh H L
HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.
Seminars in cancer biology 1999;9(1):37-46.
1999: Shi G P; Villadangos J A; Dranoff G; Small C; Gu L; Haley K J; Riese R; Ploegh H L; Chapman H A
Cathepsin S required for normal MHC class II peptide loading and germinal center development.
Immunity 1999;10(2):197-206.
1998: Sykulev Y; Vugmeyster Y; Brunmark A; Ploegh H L; Eisen H N
Peptide antagonism and T cell receptor interactions with peptide-MHC complexes.
Immunity 1998;9(4):475-83.
1998: Vugmeyster Y; Glas R; Pérarnau B; Lemonnier F A; Eisen H; Ploegh H
Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12492-7.
1998: Wolf P R; Tourne S; Miyazaki T; Benoist C; Mathis D; Ploegh H L
The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed.
European journal of immunology 1998;28(9):2605-18.
1998: Schust D J; Tortorella D; Seebach J; Phan C; Ploegh H L
Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.
The Journal of experimental medicine 1998;188(3):497-503.
1998: Tortorella D; Story C M; Huppa J B; Wiertz E J; Jones T R; Bacik I; Bennink J R; Yewdell J W; Ploegh H L
Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential.
The Journal of cell biology 1998;142(2):365-76.
1998: Bogyo M; Shin S; McMaster J S; Ploegh H L
Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes.
Chemistry & biology 1998;5(6):307-20.
1998: Riese R J; Mitchell R N; Villadangos J A; Shi G P; Palmer J T; Karp E R; De Sanctis G T; Ploegh H L; Chapman H A
Cathepsin S activity regulates antigen presentation and immunity.
The Journal of clinical investigation 1998;101(11):2351-63.
1998: Glas R; Bogyo M; McMaster J S; Gaczynska M; Ploegh H L
A proteolytic system that compensates for loss of proteasome function.
Nature 1998;392(6676):618-22.
1998: Nakagawa T; Roth W; Wong P; Nelson A; Farr A; Deussing J; Villadangos J A; Ploegh H; Peters C; Rudensky A Y
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
Science (New York, N.Y.) 1998;280(5362):450-3.
1998: Deussing J; Roth W; Saftig P; Peters C; Ploegh H L; Villadangos J A
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4516-21.
1998: Ploegh H L
Viral strategies of immune evasion.
Science (New York, N.Y.) 1998;280(5361):248-53.
1998: Sernee M F; Ploegh H L; Schust D J
Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents.
Molecular immunology 1998;35(3):177-88.
1998: Huppa J B; Ploegh H L
The eS-Sence of -SH in the ER.
Cell 1998;92(2):145-8.
1997: Simmons W A; Roopenian D C; Summerfield S G; Jones R C; Galocha B; Christianson G J; Maika S D; Zhou M; Gaskell S J; Bordoli R S; Ploegh H L; Slaughter C A; Lindahl K F; Hammer R E; Taurog J D
A new MHC locus that influences class I peptide presentation.
Immunity 1997;7(5):641-51.
1997: Rehm A; Ploegh H L
The betagamma subunits of heterotrimeric G proteins acquire detergent insolubility directly at the plasma membrane.
FEBS letters 1997;416(1):39-44.
1997: Villadangos J A; Riese R J; Peters C; Chapman H A; Ploegh H L
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism.
The Journal of experimental medicine 1997;186(4):549-60.
1997: Huppa J B; Ploegh H L
In vitro translation and assembly of a complete T cell receptor-CD3 complex.
The Journal of experimental medicine 1997;186(3):393-403.
1997: Huppa J B; Ploegh H L
The alpha chain of the T cell antigen receptor is degraded in the cytosol.
Immunity 1997;7(1):113-22.
1997: Bogyo M; McMaster J S; Gaczynska M; Tortorella D; Goldberg A L; Ploegh H
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6629-34.
1997: Galocha B; Hill A; Barnett B C; Dolan A; Raimondi A; Cook R F; Brunner J; McGeoch D J; Ploegh H L
The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues.
The Journal of experimental medicine 1997;185(9):1565-72.
1997: Rehm A; Ploegh H L
Assembly and intracellular targeting of the betagamma subunits of heterotrimeric G proteins.
The Journal of cell biology 1997;137(2):305-17.
1997: Wiertz E J; Mukherjee S; Ploegh H L
Viruses use stealth technology to escape from the host immune system.
Molecular medicine today 1997;3(3):116-23.
1997: Lagaudrière-Gesbert C; Lebel-Binay S; Wiertz E; Ploegh H L; Fradelizi D; Conjeaud H
The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2790-7.
1997: Kleijnen M F; Huppa J B; Lucin P; Mukherjee S; Farrell H; Campbell A E; Koszinowski U H; Hill A B; Ploegh H L
A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface.
The EMBO journal 1997;16(4):685-94.
1997: Rehm A; Ploegh H L
Monoclonal antibodies that distinguish between free and complexed heterotrimeric G protein beta subunits.
FEBS letters 1997;402(2-3):277-85.
1997: Machold R P; Wiertz E J; Jones T R; Ploegh H L
The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains.
The Journal of experimental medicine 1997;185(2):363-6.
1997: Bogyo M; Gaczynska M; Ploegh H L
Proteasome inhibitors and antigen presentation.
Biopolymers 1997;43(4):269-80.
1996: Machold R P; Ploegh H L
Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies.
The Journal of experimental medicine 1996;184(6):2251-9.
1996: Wiertz E J; Tortorella D; Bogyo M; Yu J; Mothes W; Jones T R; Rapoport T A; Ploegh H L
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.
Nature 1996;384(6608):432-8.
1996: Schust D J; Hill A B; Ploegh H L
Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3375-80.
1996: Tomazin R; Hill A B; Jugovic P; York I; van Endert P; Ploegh H L; Andrews D W; Johnson D C
Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.
The EMBO journal 1996;15(13):3256-66.
1996: Yilla M; Oleinick J; Ploegh H L
A monoclonal antibody that causes the heterotrimeric G-protein G(o) to release its beta gamma subunits.
FEBS letters 1996;387(1):16-22.
1996: Riese R J; Wolf P R; Brömme D; Natkin L R; Villadangos J A; Ploegh H L; Chapman H A
Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading.
Immunity 1996;4(4):357-66.
1996: Wiertz E J; Jones T R; Sun L; Bogyo M; Geuze H J; Ploegh H L
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol.
Cell 1996;84(5):769-79.
1995: Hill A; Jugovic P; York I; Russ G; Bennink J; Yewdell J; Ploegh H; Johnson D
Herpes simplex virus turns off the TAP to evade host immunity.
Nature 1995;375(6530):411-5.
1995: Ljunggren H G; Van Kaer L; Sabatine M S; Auchincloss H; Tonegawa S; Ploegh H L
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice.
International immunology 1995;7(6):975-84.
1995: Machold R P; Andrée S; Van Kaer L; Ljunggren H G; Ploegh H L
Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains.
The Journal of experimental medicine 1995;181(3):1111-22.
1995: Martien van Santen H; Woolsey A; Rickardt P G; Van Kaer L; Baas E J; Berns A; Tonegawa S; Ploegh H L
Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene.
The Journal of experimental medicine 1995;181(2):787-92.
1995: Ljunggren H G; Van Kaer L; Ashton-Rickardt P G; Tonegawa S; Ploegh H L
Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice.
European journal of immunology 1995;25(1):174-8.
1995: Hill A; Ploegh H
Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):341-3.
1995: Ploegh H L
Trafficking and assembly of MHC molecules: how viruses elude the immune system.
Cold Spring Harbor symposia on quantitative biology 1995;60():263-6.
1995: Wolf P R; Ploegh H L
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway.
Annual review of cell and developmental biology 1995;11():267-306.
1995: Heemels M T; Ploegh H
Generation, translocation, and presentation of MHC class I-restricted peptides.
Annual review of biochemistry 1995;64():463-91.
1994: Heemels M T; Ploegh H L
Substrate specificity of allelic variants of the TAP peptide transporter.
Immunity 1994;1(9):775-84.
1994: Schumacher T N; Kantesaria D V; Serreze D V; Roopenian D C; Ploegh H L
Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):13004-8.
1994: Bijlmakers M J; Benaroch P; Ploegh H L
Mapping functional regions in the lumenal domain of the class II-associated invariant chain.
The Journal of experimental medicine 1994;180(2):623-9.
1994: Bijlmakers M J; Benaroch P; Ploegh H L
Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.
The EMBO journal 1994;13(11):2699-707.
1994: Tulp A; Verwoerd D; Dobberstein B; Ploegh H L; Pieters J
Isolation and characterization of the intracellular MHC class II compartment.
Nature 1994;369(6476):120-6.
1994: Tan A; van den Broek L; Bolscher J; Vermaas D J; Pastoors L; van Boeckel C; Ploegh H
Introduction of oxygen into the alkyl chain of N-decyl-dNM decreases lipophilicity and results in increased retention of glucose residues on N-linked oligosaccharides.
Glycobiology 1994;4(2):141-9.
1994: Schumacher T N; Kantesaria D V; Heemels M T; Ashton-Rickardt P G; Shepherd J C; Fruh K; Yang Y; Peterson P A; Tonegawa S; Ploegh H L
Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.
The Journal of experimental medicine 1994;179(2):533-40.
1993: Heemels M T; Schumacher T N; Wonigeit K; Ploegh H L
Peptide translocation by variants of the transporter associated with antigen processing.
Science (New York, N.Y.) 1993;262(5142):2059-63.
1993: Ashton-Rickardt P G; Van Kaer L; Schumacher T N; Ploegh H L; Tonegawa S
Repertoire-determining role of peptide in the positive selection of CD8+ T cells.
Immunological reviews 1993;135():157-82.
1993: Yilla M; Tan A; Ito K; Miwa K; Ploegh H L
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells.
The Journal of biological chemistry 1993;268(25):19092-100.
1993: Shepherd J C; Schumacher T N; Ashton-Rickardt P G; Imaeda S; Ploegh H L; Janeway C A; Tonegawa S
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective.
Cell 1993;74(3):577-84.
1993: Heemels M T; Ploegh H
Antigen presentation: untapped peptides.
Current biology : CB 1993;3(6):380-3.
1993: Bijlmakers M J; Neefjes J J; Wojcik-Jacobs E H; Ploegh H L
The assembly of H2-Kb class I molecules translated in vitro requires oxidized glutathione and peptide.
European journal of immunology 1993;23(6):1305-13.
1993: Ashton-Rickardt P G; Van Kaer L; Schumacher T N; Ploegh H L; Tonegawa S
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus.
Cell 1993;73(5):1041-9.
1993: Neefjes J J; Dierx J; Ploegh H L
The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions.
European journal of immunology 1993;23(4):840-5.
1993: van der Voorn L; Tol O; Hengeveld T M; Ploegh H L
Structural and functional studies on the G(o) protein.
The Journal of biological chemistry 1993;268(7):5131-8.
1993: Bijlmakers M J; Ploegh H L
Putting together an MHC class I molecule.
Current opinion in immunology 1993;5(1):21-6.
1993: Schaap D; van der Wal J; van Blitterswijk W J; van der Bend R L; Ploegh H L
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
The Biochemical journal 1993;289 ( Pt 3)():875-81.
1993: Eichholtz T; de Bont D B; de Widt J; Liskamp R M; Ploegh H L
A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor.
The Journal of biological chemistry 1993;268(3):1982-6.
1992: Van Kaer L; Ashton-Rickardt P G; Ploegh H L; Tonegawa S
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.
Cell 1992;71(7):1205-14.
1992: Eichholtz T; Vossebeld P; van Overveld M; Ploegh H
Activation of protein kinase C accelerates internalization of transferrin receptor but not of major histocompatibility complex class I, independent of their phosphorylation status.
The Journal of biological chemistry 1992;267(31):22490-5.
1992: De Bruijn M L; Nieland J D; Schumacher T N; Ploegh H L; Kast W M; Melief C J
Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses.
European journal of immunology 1992;22(11):3013-20.
1992: van der Voorn L; Hengeveld T M; Ploegh H L
Subunit interactions of the Go protein.
FEBS letters 1992;308(1):75-8.
1992: van der Voorn L; Ploegh H L
The WD-40 repeat.
FEBS letters 1992;307(2):131-4.
1992: Baas E J; van Santen H M; Kleijmeer M J; Geuze H J; Peters P J; Ploegh H L
Peptide-induced stabilization and intracellular localization of empty HLA class I complexes.
The Journal of experimental medicine 1992;176(1):147-56.
1992: Deres K; Schumacher T N; Wiesmüller K H; Stevanovic S; Greiner G; Jung G; Ploegh H L
Preferred size of peptides that bind to H-2 Kb is sequence dependent.
European journal of immunology 1992;22(6):1603-8.
1992: Schumacher T N; Van Bleek G M; Heemels M T; Deres K; Li K W; Imarai M; Vernie L N; Nathenson S G; Ploegh H L
Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules.
European journal of immunology 1992;22(6):1405-12.
1992: Neefjes J J; Smit L; Gehrmann M; Ploegh H L
The fate of the three subunits of major histocompatibility complex class I molecules.
European journal of immunology 1992;22(6):1609-14.
1992: Tan A; Bolscher J; Feltkamp C; Ploegh H
Retrograde transport from the Golgi region to the endoplasmic reticulum is sensitive to GTP gamma S.
The Journal of cell biology 1992;116(6):1357-67.
1992: Verheijden G F; Moolenaar W H; Ploegh H L
Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells.
The Biochemical journal 1992;282 ( Pt 1)():115-21.
1992: Neefjes J J; Ploegh H L
Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.
The EMBO journal 1992;11(2):411-6.
1992: Ploegh H L
MHC products: biosynthesis, intracellular traffic, and "empty" molecules.
Cold Spring Harbor symposia on quantitative biology 1992;57():565-70.
1991: De Bruijn M L; Schumacher T N; Nieland J D; Ploegh H L; Kast W M; Melief C J
Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses.
European journal of immunology 1991;21(12):2963-70.
1991: Neefjes J J; Schumacher T N; Ploegh H L
Assembly and intracellular transport of major histocompatibility complex molecules.
Current opinion in cell biology 1991;3(4):601-9.
1991: Tan A; van den Broek L; van Boeckel S; Ploegh H; Bolscher J
Chemical modification of the glucosidase inhibitor 1-deoxynojirimycin. Structure-activity relationships.
The Journal of biological chemistry 1991;266(22):14504-10.
1991: Schumacher T N; De Bruijn M L; Vernie L N; Kast W M; Melief C J; Neefjes J J; Ploegh H L
Peptide selection by MHC class I molecules.
Nature 1991;350(6320):703-6.
1990: Ploegh H; Neefjes J J
Protein glycosylation.
Current opinion in cell biology 1990;2(6):1125-30.
1990: Schaap D; de Widt J; van der Wal J; Vandekerckhove J; van Damme J; Gussow D; Ploegh H L; van Blitterswijk W J; van der Bend R L
Purification, cDNA-cloning and expression of human diacylglycerol kinase.
FEBS letters 1990;275(1-2):151-8.
1990: Neefjes J J; Hengeveld T; Tol O; Ploegh H L
Intracellular interactions of transferrin and its receptor during biosynthesis.
The Journal of cell biology 1990;111(4):1383-92.
1990: Schumacher T N; Heemels M T; Neefjes J J; Kast W M; Melief C J; Ploegh H L
Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro.
Cell 1990;62(3):563-7.
1990: Neefjes J J; Stollorz V; Peters P J; Geuze H J; Ploegh H L
The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route.
Cell 1990;61(1):171-83.
1990: Eichholtz T; Alblas J; van Overveld M; Moolenaar W; Ploegh H
A pseudosubstrate peptide inhibits protein kinase C-mediated phosphorylation in permeabilized Rat-1 cells.
FEBS letters 1990;261(1):147-50.
1990: Neefjes J J; De Bruijn M L; Boog C J; Nieland J D; Boes J; Melief C J; Ploegh H L
N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response.
The Journal of experimental medicine 1990;171(2):583-8.
1990: Stam N J; Vroom T M; Peters P J; Pastoors E B; Ploegh H L
HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy.
International immunology 1990;2(2):113-25.
1989: Stam N J; Kast W M; Voordouw A C; Pastoors L B; van der Hoeven F A; Melief C J; Ploegh H L
Lack of correlation between levels of MHC class I antigen and susceptibility to lysis of small cellular lung carcinoma (SCLC) by natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):4113-7.
1989: Neefjes J J; Lindhout J; Broxterman H J; van der Marel G A; van Boom J H; Ploegh H L
Non-carrier-mediated uptake of the mannosidase I inhibitor 1-deoxymannojirimycin by K562 erythroleukemic cells.
The Journal of biological chemistry 1989;264(17):10271-5.
1989: Boog C J; Neefjes J J; Boes J; Ploegh H L; Melief C J
Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells.
European journal of immunology 1989;19(3):537-42.
1989: Gruters R A; Calafat J; Vennegoor C J; Jansen H; Ploegh H L
Structural heterogeneity of a human melanoma-associated antigen.
Cancer research 1989;49(2):459-65.
1988: Bolscher J G; van der Bijl M M; Neefjes J J; Hall A; Smets L A; Ploegh H L
Ras (proto)oncogene induces N-linked carbohydrate modification: temporal relationship with induction of invasive potential.
The EMBO journal 1988;7(11):3361-8.
1988: Neefjes J J; Verkerk J M; Broxterman H J; van der Marel G A; van Boom J H; Ploegh H L
Recycling glycoproteins do not return to the cis-Golgi.
The Journal of cell biology 1988;107(1):79-87.
1988: Neefjes J J; Ploegh H L
Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association.
European journal of immunology 1988;18(5):801-10.
1987: Gruters R A; Neefjes J J; Tersmette M; de Goede R E; Tulp A; Huisman H G; Miedema F; Ploegh H L
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Nature 1987;330(6143):74-7.
1987: Kievits F; Ivanyi P; Krimpenfort P; Berns A; Ploegh H L
HLA-restricted recognition of viral antigens in HLA transgenic mice.
Nature 1987;329(6138):447-9.

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