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Michael Ploug

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

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Anatomy

Procedures

Polyacrylamide Gel Electrophoresis

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Co-Publications
Name
29
Danø, Keld
18
Behrendt, Niels
17
Gårdsvoll, Henrik
14
Høyer-Hansen, Gunilla
12
Rønne, E
9
Lund, Leif
8
Jørgensen, Thomas
5
Hansen, Line
5
Nielsen, Boye
4
Roepstorff, Peter
4
Rømer, John
3
Hansen, Niels Ebbe
2
Holm, Arne
2
Gilquin, Bernard
2
Green, Kirsty

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Publications

TOP 3
Bache Nicolai; Rand Kasper D; Roepstorff Peter; Ploug Michael; Jørgensen Thomas J D
Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry.
Green Kirsty A; Almholt Kasper; Ploug Michael; Rønø Birgitte; Castellino Francis J; Johnsen Morten; Bugge Thomas H; Rømer John; Lund Leif R
Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.
Hillig Thore; Engelholm Lars H; Ingvarsen Signe; Madsen Daniel H; Gårdsvoll Henrik; Larsen Jørgen K; Ploug Michael; Danø Keld; Kjøller Lars; Behrendt Niels
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor.

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All Publications

2008: Bache Nicolai; Rand Kasper D; Roepstorff Peter; Ploug Michael; Jørgensen Thomas J D
Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry.
Journal of the American Society for Mass Spectrometry 2008;19(12):1719-25.
2008: Green Kirsty A; Almholt Kasper; Ploug Michael; Rønø Birgitte; Castellino Francis J; Johnsen Morten; Bugge Thomas H; Rømer John; Lund Leif R
Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.
The Journal of investigative dermatology 2008;128(8):2092-101.
2008: Hillig Thore; Engelholm Lars H; Ingvarsen Signe; Madsen Daniel H; Gårdsvoll Henrik; Larsen Jørgen K; Ploug Michael; Danø Keld; Kjøller Lars; Behrendt Niels
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor.
The Journal of biological chemistry 2008;283(22):15217-23.
2008: Hansen Line V; Laerum Ole D; Illemann Martin; Nielsen Boye S; Ploug Michael
Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2008;122(4):734-41.
2008: Jacobsen B; Ploug M
The urokinase receptor and its structural homologue C4.4A in human cancer: expression, prognosis and pharmacological inhibition.
Current medicinal chemistry 2008;15(25):2559-73.
2008: Kjaergaard Magnus; Hansen Line V; Jacobsen Benedikte; Gardsvoll Henrik; Ploug Michael
Structure and ligand interactions of the urokinase receptor (uPAR).
Frontiers in bioscience : a journal and virtual library 2008;13():5441-61.
2007: Hansen Line V; Skov Birgit G; Ploug Michael; Pappot Helle
Tumour cell expression of C4.4A, a structural homologue of the urokinase receptor, correlates with poor prognosis in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2007;58(2):260-6.
2007: Kjaergaard Magnus; Gårdsvoll Henrik; Hirschberg Daniel; Nielbo Steen; Mayasundari Anand; Peterson Cynthia B; Jansson Anna; Jørgensen Thomas J D; Poulsen Flemming M; Ploug Michael
Solution structure of recombinant somatomedin B domain from vitronectin produced in Pichia pastoris.
Protein science : a publication of the Protein Society 2007;16(9):1934-45.
2007: Pass Jesper; Jögi Annika; Lund Ida K; Rønø Birgitte; Rasch Morten G; Gårdsvoll Henrik; Lund Leif R; Ploug Michael; Rømer John; Danø Keld; Høyer-Hansen Gunilla
Murine monoclonal antibodies against murine uPA receptor produced in gene-deficient mice: inhibitory effects on receptor-mediated uPA activity in vitro and in vivo.
Thrombosis and haemostasis 2007;97(6):1013-22.
2007: Gårdsvoll Henrik; Ploug Michael
Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region.
The Journal of biological chemistry 2007;282(18):13561-72.
2007: Gårdsvoll Henrik; Hansen Line V; Jørgensen Thomas J D; Ploug Michael
A new tagging system for production of recombinant proteins in Drosophila S2 cells using the third domain of the urokinase receptor.
Protein expression and purification 2007;52(2):384-94.
2007: Jacobsen Benedikte; Gårdsvoll Henrik; Juhl Funch Gitte; Ostergaard Søren; Barkholt Vibeke; Ploug Michael
One-step affinity purification of recombinant urokinase-type plasminogen activator receptor using a synthetic peptide developed by combinatorial chemistry.
Protein expression and purification 2007;52(2):286-96.
2006: Gårdsvoll Henrik; Gilquin Bernard; Le Du Marie Hélène; Ménèz Andre; Jørgensen Thomas J D; Ploug Michael
Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking.
The Journal of biological chemistry 2006;281(28):19260-72.
2006: Lund Leif R; Green Kirsty A; Stoop Allart A; Ploug Michael; Almholt Kasper; Lilla Jennifer; Nielsen Boye S; Christensen Ib J; Craik Charles S; Werb Zena; Danø Keld; Rømer John
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.
The EMBO journal 2006;25(12):2686-97.
2006: Chaurasia Pratima; Aguirre-Ghiso Julio A; Liang Olin D; Gardsvoll Henrik; Ploug Michael; Ossowski Liliana
A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth.
The Journal of biological chemistry 2006;281(21):14852-63.
2005: Jørgensen Thomas J D; Bache Nicolai; Roepstorff Peter; Gårdsvoll Henrik; Ploug Michael
Collisional activation by MALDI tandem time-of-flight mass spectrometry induces intramolecular migration of amide hydrogens in protonated peptides.
Molecular & cellular proteomics : MCP 2005;4(12):1910-9.
2005: Llinas Paola; Le Du Marie Hélène; Gårdsvoll Henrik; Danø Keld; Ploug Michael; Gilquin Bernard; Stura Enrico A; Ménez André
Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide.
The EMBO journal 2005;24(9):1655-63.
2005: Danø Keld; Behrendt Niels; Høyer-Hansen Gunilla; Johnsen Morten; Lund Leif R; Ploug Michael; Rømer John
Plasminogen activation and cancer.
Thrombosis and haemostasis 2005;93(4):676-81.
2005: Jørgensen Thomas J D; Gårdsvoll Henrik; Ploug Michael; Roepstorff Peter
Intramolecular migration of amide hydrogens in protonated peptides upon collisional activation.
Journal of the American Chemical Society 2005;127(8):2785-93.
2004: Jørgensen Thomas J D; Gårdsvoll Henrik; Danø Keld; Roepstorff Peter; Ploug Michael
Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry.
Biochemistry 2004;43(47):15044-57.
2004: Piironen Timo; Laursen Birgitte; Pass Jesper; List Karin; Gårdsvoll Henrik; Ploug Michael; Danø Keld; Høyer-Hansen Gunilla
Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor.
Clinical chemistry 2004;50(11):2059-68.
2004: Hansen Line V; Gårdsvoll Henrik; Nielsen Boye S; Lund Leif R; Danø Keld; Jensen Ole N; Ploug Michael
Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.
The Biochemical journal 2004;380(Pt 3):845-57.
2004: Gårdsvoll Henrik; Werner Finn; Søndergaard Leif; Danø Keld; Ploug Michael
Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites.
Protein expression and purification 2004;34(2):284-95.
2004: Romer John; Nielsen Boye Schnack; Ploug Michael
The urokinase receptor as a potential target in cancer therapy.
Current pharmaceutical design 2004;10(19):2359-76.
2003: Ploug Michael
Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor.
Current pharmaceutical design 2003;9(19):1499-528.
2002: Ploug M; Gårdsvoll H; Jørgensen T J D; Lønborg Hansen L; Danø K
Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy.
Biochemical Society transactions 2002;30(2):177-83.
2001: Ploug M; Østergaard S; Gårdsvoll H; Kovalski K; Holst-Hansen C; Holm A; Ossowski L; Danø K
Peptide-derived antagonists of the urokinase receptor. affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation.
Biochemistry 2001;40(40):12157-68.
2001: Solberg H; Ploug M; Høyer-Hansen G; Nielsen B S; Lund L R
The murine receptor for urokinase-type plasminogen activator is primarily expressed in tissues actively undergoing remodeling.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(2):237-46.
2000: List K; Jensen O N; Bugge T H; Lund L R; Ploug M; Danø K; Behrendt N
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.
Biochemistry 2000;39(3):508-15.
1999: Gårdsvoll H; Danø K; Ploug M
Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis.
The Journal of biological chemistry 1999;274(53):37995-8003.
1998: Ploug M
Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and III participate in the assembly of a composite ligand-binding site.
Biochemistry 1998;37(47):16494-505.
1998: Ploug M; Rahbek-Nielsen H; Nielsen P F; Roepstorff P; Dano K
Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells.
The Journal of biological chemistry 1998;273(22):13933-43.
1998: Ploug M; Ostergaard S; Hansen L B; Holm A; Danø K
Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation.
Biochemistry 1998;37(11):3612-22.
1997: Høyer-Hansen G; Behrendt N; Ploug M; Danø K; Preissner K T
The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction.
FEBS letters 1997;420(1):79-85.
1997: Høyer-Hansen G; Ploug M; Behrendt N; Rønne E; Danø K
Cell-surface acceleration of urokinase-catalyzed receptor cleavage.
European journal of biochemistry / FEBS 1997;243(1-2):21-6.
1997: Plesner T; Behrendt N; Ploug M
Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR.
Stem cells (Dayton, Ohio) 1997;15(6):398-408.
1995: Ploug M; Rahbek-Nielsen H; Ellis V; Roepstorff P; Danø K
Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction.
Biochemistry 1995;34(39):12524-34.
1994: Ploug M; Ellis V
Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins.
FEBS letters 1994;349(2):163-8.
1994: Ploug M; Ellis V; Danø K
Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor.
Biochemistry 1994;33(30):8991-7.
1994: Plesner T; Ploug M; Ellis V; Rønne E; Høyer-Hansen G; Wittrup M; Pedersen T L; Tscherning T; Danø K; Hansen N E
The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils.
Blood 1994;83(3):808-15.
1994: Rønne E; Behrendt N; Ploug M; Nielsen H J; Wöllisch E; Weidle U; Danø K; Høyer-Hansen G
Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay.
Journal of immunological methods 1994;167(1-2):91-101.
1994: Weidle U H; Wöllisch E; Rønne E; Ploug M; Behrendt N; de Vries T J; Quax P H; Verheijen J H; van Muijen G N; Ruiter D J
Studies on functional and structural role of urokinase receptor and other components of the plasminogen activation system in malignancy.
Annales de biologie clinique 1994;52(11):775-82.
1993: Ploug M; Kjalke M; Rønne E; Weidle U; Høyer-Hansen G; Danø K
Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins.
The Journal of biological chemistry 1993;268(23):17539-46.
1993: Behrendt N; Ploug M; Rønne E; Høyer-Hansen G; Danø K
Cellular receptor for urokinase-type plasminogen activator: protein structure.
Methods in enzymology 1993;223():207-22.
1992: Høyer-Hansen G; Rønne E; Solberg H; Behrendt N; Ploug M; Lund L R; Ellis V; Danø K
Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain.
The Journal of biological chemistry 1992;267(25):18224-9.
1992: Møller L B; Ploug M; Blasi F
Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activator.
European journal of biochemistry / FEBS 1992;208(2):493-500.
1992: Ploug M; Eriksen J; Plesner T; Hansen N E; Danø K
A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria.
European journal of biochemistry / FEBS 1992;208(2):397-404.
1992: Solberg H; Løber D; Eriksen J; Ploug M; Rønne E; Behrendt N; Danø K; Høyer-Hansen G
Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator.
European journal of biochemistry / FEBS 1992;205(2):451-8.
1992: Ploug M; Stoffer B; Jensen A L
In situ alkylation of cysteine residues in a hydrophobic membrane protein immobilized on polyvinylidene difluoride membranes by electroblotting prior to microsequence and amino acid analysis.
Electrophoresis 1992;13(3):148-53.
1992: Ploug M; Plesner T; Rønne E; Ellis V; Høyer-Hansen G; Hansen N E; Danø K
The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria.
Blood 1992;79(6):1447-55.
1991: Rønne E; Behrendt N; Ellis V; Ploug M; Danø K; Høyer-Hansen G
Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor.
FEBS letters 1991;288(1-2):233-6.
1991: Ploug M; Behrendt N; Løber D; Danø K
Protein structure and membrane anchorage of the cellular receptor for urokinase-type plasminogen activator.
Seminars in thrombosis and hemostasis 1991;17(3):183-93.
1991: Behrendt N; Ploug M; Patthy L; Houen G; Blasi F; Danø K
The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator.
The Journal of biological chemistry 1991;266(12):7842-7.
1991: Ploug M; Rønne E; Behrendt N; Jensen A L; Blasi F; Danø K
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.
The Journal of biological chemistry 1991;266(3):1926-33.
1990: Blasi F; Behrendt N; Cubellis M V; Ellis V; Lund L R; Masucci M T; Møller L B; Olson D P; Pedersen N; Ploug M
The urokinase receptor and regulation of cell surface plasminogen activation.
Cell differentiation and development : the official journal of the International Society of Developmental Biologists 1990;32(3):247-53.
1990: Behrendt N; Rønne E; Ploug M; Petri T; Løber D; Nielsen L S; Schleuning W D; Blasi F; Appella E; Danø K
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.
The Journal of biological chemistry 1990;265(11):6453-60.
1989: Ploug M; Jensen A L; Barkholt V
Determination of amino acid compositions and NH2-terminal sequences of peptides electroblotted onto PVDF membranes from tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis: application to peptide mapping of human complement component C3.
Analytical biochemistry 1989;181(1):33-9.
1988: Jessen T E; Faarvang K L; Ploug M
Carbohydrate as covalent crosslink in human inter-alpha-trypsin inhibitor: a novel plasma protein structure.
FEBS letters 1988;230(1-2):195-200.
1987: Behrendt N; Hansen O C; Ploug M; Barkholt V; Koch C
Localization and functional significance of a polymorphic determinant in the third component of human complement.
Molecular immunology 1987;24(10):1097-103.
1985: Ploug M; Jessen T E; Welinder K G; Barkholt V
Hemolytic plate assay for quantification of active human complement component C3 using methylamine-treated plasma as complement source.
Analytical biochemistry 1985;146(2):411-7.

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