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Eckhard Podack

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Natasa Strbo; Monica Vaccari; Donald Stablein; Melvin N Doster; Eva Fisher; Genoveffa Franchini; Louis Gonzalez; Michael A Kolber; Savita Pahwa; Eckhard R Podack
Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus.
Samia Q Khan; Taylor H Schreiber; Matthew S Tsai; Dietlinde Wolf; Vadim Deyev; Eckhard R Podack
Cloning, expression, and functional characterization of TL1A-Ig.
Ryan McCormack; Jahir E Ramos; Motoaki Shiratsuchi; Lesley R de Armas; Eckhard R Podack
Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1.

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2013: Natasa Strbo; Monica Vaccari; Donald Stablein; Melvin N Doster; Eva Fisher; Genoveffa Franchini; Louis Gonzalez; Michael A Kolber; Savita Pahwa; Eckhard R Podack
Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2495-9.
2013: Samia Q Khan; Taylor H Schreiber; Matthew S Tsai; Dietlinde Wolf; Vadim Deyev; Eckhard R Podack
Cloning, expression, and functional characterization of TL1A-Ig.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(4):1540-50.
2013: Ryan McCormack; Jahir E Ramos; Motoaki Shiratsuchi; Lesley R de Armas; Eckhard R Podack
Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1.
Journal of innate immunity 2013;5(2):185-94.
2013: Yu Zhang; Yair Eliav; Eckhard R Podack; Taylor H Schreiber; Seung-Uon Shin; Tamar Tadmor; Joseph D Rosenblatt
B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion.
Cancer immunology, immunotherapy : CII 2013;62(1):87-99.
2012: Taylor H Schreiber; Dietlinde Wolf; Maria Bodero; Louis Gonzalez; Eckhard R Podack
T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(7):3311-8.
2012: Pradeep B J Reddy; Sachin Mulik; Toshiro Niki; Eckhard R Podack; Naveen K Rajasagi; Taylor H Schreiber; Amol Suryawanshi; Tamara Veiga-Parga; Mitsuomi Hirashima; Barry T Rouse
TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions.
Journal of virology 2012;86(19):10606-20.
2012: Dietlinde Wolf; Sen Li; Phillip Ruiz; Taylor H Schreiber; Panagiotis Tryphonopoulos; Andreas G Tzakis; Eckhard R Podack
Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival.
Transplantation 2012;94(6):569-74.
2012: Guoyan Cheng; Eckhard R Podack; Matthew S Tsai; Aixin Yu; Xiaomei Yuan; Thomas R Malek
IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1780-91.
2012: Shinichi Somada; Xun Sun; Ryoichi Takayanagi; Hirotada Akiho; Kuniomi Honda; Eikichi Ihara; Hiromi Muta; Kazuhiko Nakamura; Eckhard R Podack; Yasunobu Yoshikai; Kenzaburo Tani
CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease.
Digestive diseases and sciences 2012;57(8):2031-7.
2011: Takafumi Fuchiwaki; Kenjiro Fujimura; Hideyuki Kawauchi; Hiromi Muta; Eckhard R Podack; Kensuke Shibata; Xun Sun; Hisakata Yamada; Yasunobu Yoshikai
The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice.
European journal of immunology 2011;41(10):2947-54.
2011: Yehuda E Deutsch; Eckhard R Podack; Tamar Tadmor; Joseph D Rosenblatt
CD30: an important new target in hematologic malignancies.
Leukemia & lymphoma 2011;52(9):1641-54.
2011: Tamar Tadmor; Yu Zhang; Hyun-Mi Cho; Eckhard R Podack; Joseph D Rosenblatt
The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-tumor response in a murine tumor model.
Cancer immunology, immunotherapy : CII 2011;60(5):609-19.
2011: Natasa Strbo; Monica Vaccari; Savita Pahwa; Michael A Kolber; Eva Fisher; Louis Gonzalez; Melvin N Doster; Anna Hryniewicz; Barbara K Felber; George N Pavlakis; Genoveffa Franchini; Eckhard R Podack
Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa.
Vaccine 2011;29(14):2619-25.
2011: Yanping Xiao; Seiichi Motomura; Vadim Deyev; Eckhard R Podack
TNF superfamily member 13, APRIL, inhibits allergic lung inflammation.
European journal of immunology 2011;41(1):164-71.
2011: Taylor H Schreiber; Dietlinde Wolf; Eckhard R Podack
The role of TNFRSF25:TNFSF15 in disease… and health?
Advances in experimental medicine and biology 2011;691():289-98.
2010: Xun Sun; Hisakata Yamada; Kensuke Shibata; Hiromi Muta; Kenzaburo Tani; Eckhard R Podack; Yoichiro Iwakura; Yasunobu Yoshikai
CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7671-80.
2010: Taylor Schreiber; Dietlinde Wolf; Matthew S Tsai; Jackie Chirinos; Vadim V Deyev; Louis Gonzalez; Thomas R Malek; Robert B Levy; Eckhard R Podack
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation.
The Journal of clinical investigation 2010;120(10):3629-40.
2010: Xun Sun; Hisakata Yamada; Kensuke Shibata; Hiromi Muta; Kenzaburo Tani; Eckhard R Podack; Yasunobu Yoshikai
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2222-30.
2010: Taylor Schreiber; Luis E Raez; Joseph D Rosenblatt; Eckhard R Podack
Tumor immunogenicity and responsiveness to cancer vaccine therapy: the state of the art.
Seminars in immunology 2010;22(3):105-12.
2010: Natasa Strbo; Savita Pahwa; Michael A Kolber; L Gonzalez; E Fisher; Eckhard R Podack
Cell-secreted Gp96-Ig-peptide complexes induce lamina propria and intraepithelial CD8+ cytotoxic T lymphocytes in the intestinal mucosa.
Mucosal immunology 2010;3(2):182-92.
2009: Taylor Schreiber; Eckhard R Podack
A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas.
British journal of cancer 2009;101(3):381-6.
2009: Eckhard R Podack
How to polymerize in order to survive.
Immunity 2009;30(5):668-70.
2009: Taylor Schreiber; Vadim Deyev; Joseph D Rosenblatt; Eckhard R Podack
Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig vaccination.
Cancer research 2009;69(5):2026-33.
2008: Yanping Xiao; Seiichi Motomura; Eckhard R Podack
APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response.
European journal of immunology 2008;38(12):3450-8.
2008: Ce Tang; Hisakata Yamada; Kensuke Shibata; Hiromi Muta; Worawidh Wajjwalku; Eckhard R Podack; Yasunobu Yoshikai
A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6316-27.
2008: Lei Fang; Rebecca Adkins; Vadim Deyev; Eckhard R Podack
Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation.
The Journal of experimental medicine 2008;205(5):1037-48.
2008: Natasa Strbo; Eckhard R Podack
Secreted heat shock protein gp96-Ig: an innovative vaccine approach.
American journal of reproductive immunology (New York, N.Y. : 1989) 2008;59(5):407-16.
2008: Satoshi Oizumi; Vadim Deyev; Koichi Yamazaki; Taylor Schreiber; Natasa Strbo; Joseph D Rosenblatt; Eckhard R Podack
Surmounting tumor-induced immune suppression by frequent vaccination or immunization in the absence of B cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(4):394-401.
2008: Xun Sun; Shinichi Somada; Kensuke Shibata; Hiromi Muta; Hisakata Yamada; Hirofumi Yoshihara; Kuniomi Honda; Kazuhiko Nakamura; Ryhoichi Takayanagi; Kenzaburo Tani; Eckhard R Podack; Yasunobu Yoshikai
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice.
Gastroenterology 2008;134(2):447-58.
2008: Sang-Yun Nam; Young-Hyun Kim; Jeong-su Do; Yun-Hwa Choi; Hyo-Jung Seo; Ho Keun Yi; Pyoung Han Hwang; Chang-Ho Song; Hern-Ku Lee; Jeong-Su Kim; Eckhard R Podack
CD30 supports lung inflammation.
International immunology 2008;20(2):177-84.
2007: Eckhard R Podack; Luis E Raez
Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96.
Expert opinion on biological therapy 2007;7(11):1679-88.
2007: Kyung H Yi; hovav nechushtan; William J Bowers; Gail R. Walker; Yu Zhang; Dien G Pham; Eckhard R Podack; Howard Federoff; Khaled A Tolba; Joseph D Rosenblatt
Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo.
Cancer research 2007;67(20):10027-37.
2007: Satoshi Oizumi; Natasa Strbo; Savita Pahwa; Vadim Deyev; Eckhard R Podack
Molecular and cellular requirements for enhanced antigen cross-presentation to CD8 cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2310-7.
2007: Eckhard R Podack; Vadim Deyev; Motoaki Shiratsuchi
Pore formers of the immune system.
Advances in experimental medicine and biology 2007;598():325-41.
2006: Luis E Raez; Joseph D Rosenblatt; Eckhard R Podack
Present and future of lung cancer vaccines.
Expert opinion on emerging drugs 2006;11(3):445-59.
2006: Kelvin P Lee; Luis E Raez; Eckhard R Podack
Heat shock protein-based cancer vaccines.
Hematology/oncology clinics of North America 2006;20(3):637-59.
2006: Natasa Strbo; Gordana Laskarin; Tatjana Bogovic Crncic; Koraljka Juretic Frankovic; Ivica Bedenicki; Vlatka Sotosek-Tokmadzic; Ljiljana Randic; Philippe Le Bouteiller; Julie Tabiasco; Eckhard R Podack; Daniel Rukavina
Short-term cytolytic mediators' expression in decidual lymphocytes is enhanced by interleukin-15.
American journal of reproductive immunology (New York, N.Y. : 1989) 2006;55(3):217-25.
2005: Luis E Raez; Steven Fein; Eckhard R Podack
Lung cancer immunotherapy.
Clinical medicine & research 2005;3(4):221-8.
2005: Hitoshi Nishimura; Toshiki Yajima; Hiromi Muta; Eckhard R Podack; Kenzaburo Tani; Yasunobu Yoshikai
A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4627-34.
2005: Luis E Raez; Edgardo S Santos; Raja Mudad; Eckhard R Podack
Clinical trials targeting lung cancer with active immunotherapy: the scope of vaccines.
Expert review of anticancer therapy 2005;5(4):635-44.
2005: Zachary Zimmerman; Alwi M Shatry; Vadim Deyev; Eckhard R Podack; Michele Mammolenti; Bruce R Blazar; Hideo Yagita; Robert B Levy
Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, Fas ligand, and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2005;11(8):576-86.
2004: Bruce R Blazar; Robert B Levy; Tak W Mak; Angela Panoskaltsis-Mortari; Hiromi Muta; Monica Jones; Melinda Roskos; Jonathan S Serody; Hideo Yagita; Eckhard R Podack; Patricia A Taylor
CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):2933-41.
2004: Luis E Raez; Peter A Cassileth; James J Schlesselman; Kasi Sridhar; Swaminathan Padmanabhan; Eva Z Fisher; Paulette A Baldie; Eckhard R Podack
Allogeneic vaccination with a B7.1 HLA-A gene-modified adenocarcinoma cell line in patients with advanced non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(14):2800-7.
2004: Lianne Marks; Norman Altman; Eckhard R Podack; Robert B Levy
Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients.
Transplantation 2004;77(6):804-12.
2003: Luis E Raez; Peter A Cassileth; James J Schlesselman; Swaminathan Padmanabhan; Eva Z Fisher; Paulette A Baldie; Kasi Sridhar; Eckhard R Podack
Induction of CD8 T-cell-Ifn-gamma response and positive clinical outcome after immunization with gene-modified allogeneic tumor cells in advanced non-small-cell lung carcinoma.
Cancer gene therapy 2003;10(11):850-8.
2003: Richard Dix; Eckhard R Podack; Scott W Cousins
Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA.
Antiviral research 2003;59(2):111-9.
2003: Gordan Gulan; Jagoda Ravlic-Gulan; Natasa Strbo; Vlatka Sotosek; Boris Nemec; Damir Matovinovic; Dusan Rubinic; Eckhard R Podack; Daniel Rukavina
Systemic and local expression of perforin in lymphocyte subsets in acute and chronic rheumatoid arthritis.
The Journal of rheumatology 2003;30(4):660-70.
2003: Natasa Strbo; Satoshi Oizumi; Vlatka Sotosek-Tokmadzic; Eckhard R Podack
Perforin is required for innate and adaptive immunity induced by heat shock protein gp96.
Immunity 2003;18(3):381-90.
2003: Richard Dix; Eckhard R Podack; Scott W Cousins
Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis.
Journal of virology 2003;77(6):3402-8.
2003: Jie Dai; Bei Liu; Marissa M Caudill; Hong Zheng; Yi Qiao; Eckhard R Podack; Zihai Li
Cell surface expression of heat shock protein gp96 enhances cross-presentation of cellular antigens and the generation of tumor-specific T cell memory.
Cancer immunity 2003;3():1.
2002: Eckhard R Podack; Natasa Strbo; Vlatka Sotosec; Hiromi Muta
CD30-governor of memory T cells?
Annals of the New York Academy of Sciences 2002;975():101-13.
2002: Natasa Strbo; Koichi Yamazaki; Kelvin Lee; Daniel Rukavina; Eckhard R Podack
Heat shock fusion protein gp96-Ig mediates strong CD8 CTL expansion in vivo.
American journal of reproductive immunology (New York, N.Y. : 1989) 2002;48(4):220-5.
2002: Gordana Laskarin; Vlatka S Tokmadzić; Natasa Strbo; Tatjana Bogović; Julia Szekeres-Bartho; Ljiljana Randić; Eckhard R Podack; Daniel Rukavina
Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity.
American journal of reproductive immunology (New York, N.Y. : 1989) 2002;48(4):201-9.
2002: Vlatka S Tokmadzić; Yoshiyuki Tsuji; Tatjana Bogović; Gordana Laskarin; Kristijan Cupurdija; Natasa Strbo; Koji Koyama; Haruki Okamura; Eckhard R Podack; Daniel Rukavina
IL-18 is present at the maternal-fetal interface and enhances cytotoxic activity of decidual lymphocytes.
American journal of reproductive immunology (New York, N.Y. : 1989) 2002;48(4):191-200.
2002: Gabriella Pár; Daniel Rukavina; Eckhard R Podack; Margit Horányi; Júlia Szekeres-Barthó; Géza Hegedüs; Mária Paál; Laszlo Szereday; Gyula Mózsik; Alajos Pár
Decrease in CD3-negative-CD8dim(+) and Vdelta2/Vgamma9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection.
Journal of hepatology 2002;37(4):514-22.
2002: Sang Yun Nam; Kyong Shin Cho; Young Moon Heo; Jong Cheon Ha; Young Hyun Kim; Ho Keun Yi; Pyong Han Hwang; Hyung Min Kim; Eckhard R Podack
Regulation of lymphocyte clustering by CD30-mediated ICAM-1 up-regulation.
Cellular immunology 2002;219(1):38-47.
2002: Helena Harlin; Eckhard R Podack; Mark Boothby; Maria-Luisa Alegre
TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2451-9.
2002: M Merger; J L Viney; Rajka Borojevic; D Steele-Norwood; Pengfei Zhou; David A Clark; Robert H Riddell; R Maric; Eckhard R Podack; Kenneth Croitoru
Defining the roles of perforin, Fas/FasL, and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine.
Gut 2002;51(2):155-63.
2002: Chika Kawasaki; Koichi Ohshima; Hiromi Muta; Koichiro Muta; Vadim Deyev; Eckhard R Podack; Masahiro Kikuchi
Prognostic value of Bcl 10 rearrangement in diffuse large B-cell lymphoma.
Leukemia & lymphoma 2002;43(4):823-6.
2002: Sunil S Metkar; Baikun Wang; Miguel Aguilar-Santelises; Srikumar M Raja; Lars Uhlin-Hansen; Eckhard R Podack; Joseph A Trapani; Christopher J Froelich
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
Immunity 2002;16(3):417-28.
2001: Ngoc L Toomey; Vadim Deyev; Charles Wood; Lawrence Boise; D Scott; L H Liu; Lisa Cabral; Eckhard R Podack; Glen N Barber; William J Harrington
Induction of a TRAIL-mediated suicide program by interferon alpha in primary effusion lymphoma.
Oncogene 2001;20(48):7029-40.
2001: Koichi Ohshima; Chika Kawasaki; Hiromi Muta; Koichiro Muta; Vadim Deyev; Seiji Haraoka; Junji Suzumiya; Eckhard R Podack; Masahiro Kikuchi
CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis.
Histopathology 2001;39(2):156-62.
2001: Koichi Ohshima; Hiromi Muta; Chika Kawasaki; Koichiro Muta; Vadim Deyev; Motonobu Kanda; Y Kumano; Eckhard R Podack; Masahiro Kikuchi
Bcl10 expression, rearrangement and mutation in MALT lymphoma: correlation with expression of nuclear factor-kappaB.
International journal of oncology 2001;19(2):283-9.
2001: Z Jiang; Eckhard R Podack; Robert B Levy
Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis.
Blood 2001;98(2):390-7.
2001: Harry Hnatyszyn; Eckhard R Podack; Andrea K Young; Rachel Seivright; Gina Spruill; Gunter Kraus
The use of real-time PCR and fluorogenic probes for rapid and accurate genotyping of newborn mice.
Molecular and cellular probes 2001;15(3):169-75.
2000: Hiromi Muta; Lawrence Boise; L Fang; Eckhard R Podack
CD30 signals integrate expression of cytotoxic effector molecules, lymphocyte trafficking signals, and signals for proliferation and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5105-11.
2000: Daniel Rukavina; Eckhard R Podack
Abundant perforin expression at the maternal-fetal interface: guarding the semiallogeneic transplant?
Immunology today 2000;21(4):160-3.
2000: L Prpić; Natasa Strbo; Vlatka Sotosek; Franjo Gruber; Eckhard R Podack; Daniel Rukavina
Assessment of perforin expression in peripheral blood lymphocytes in psoriatic patients during exacerbation of disease.
Acta dermato-venereologica. Supplementum 2000;(211):14-6.
1999: K Yamazaki; T Nguyen; Eckhard R Podack
Cutting edge: tumor secreted heat shock-fusion protein elicits CD8 cells for rejection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5178-82.
1999: Gordana Laskarin; Natasa Strbo; Vlatka Sotosek; Daniel Rukavina; Z Faust; Julia Szekeres-Bartho; Eckhard R Podack
Progesterone directly and indirectly affects perforin expression in cytolytic cells.
American journal of reproductive immunology (New York, N.Y. : 1989) 1999;42(5):312-20.
1999: Richard Lee; JP Cai; Vadim Deyev; P S Gill; Lisa Cabral; Charles Wood; Ram P Agarwal; W Xia; Lawrence Boise; Eckhard R Podack; William J Harrington
Azidothymidine and interferon-alpha induce apoptosis in herpesvirus-associated lymphomas.
Cancer research 1999;59(21):5514-20.
1999: K Yamazaki; Gina Spruill; J Rhoderick; JA Spielman; Niramol Savaraj; Eckhard R Podack
Small cell lung carcinomas express shared and private tumor antigens presented by HLA-A1 or HLA-A2.
Cancer research 1999;59(18):4642-50.
1999: Wolfgang M Schoell; Ramin Mirhashemi; B Liu; MF Janicek; Eckhard R Podack; Manuel Penalver; Hervy E Averette
Generation of tumor-specific cytotoxic T lymphocytes by stimulation with HPV type 16 E7 peptide-pulsed dendritic cells: an approach to immunotherapy of cervical cancer.
Gynecologic oncology 1999;74(3):448-55.
1999: Vlatka Sotosek; Gordana Laskarin; Natasa Strbo; Gottfried Dohr; Astrid Blaschitz; Eckhard R Podack; Daniel Rukavina
Decidual macrophages are the population of decidual adherent cells which regulates perforin expression in cytolytic cells.
American journal of reproductive immunology (New York, N.Y. : 1989) 1999;42(2):76-82.
1999: Carol K Petito; A P Kerza-Kwiatecki; Howard Gendelman; Micheline McCarthy; Avindra Nath; Eckhard R Podack; Paul Shapshak; C A Wiley
Review: neuronal injury in HIV infection.
Journal of neurovirology 1999;5(4):327-41.
1999: Eckhard R Podack
How to induce involuntary suicide: the need for dipeptidyl peptidase I.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8312-4.
1999: Natasa Strbo; Gordana Laskarin; Vlatka Sotosek; L J Randić; Eckhard R Podack; Daniel Rukavina
Modulation of perforin expression in the decidual and peripheral blood cytotoxic lymphocytes in culture.
American journal of reproductive immunology (New York, N.Y. : 1989) 1999;42(1):14-21.
1999: Roberto Chiarle; Antonello Podda; G Prolla; Eckhard R Podack; GJ Thorbecke; Giorgio Inghirami
CD30 overexpression enhances negative selection in the thymus and mediates programmed cell death via a Bcl-2-sensitive pathway.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):194-205.
1998: JA Spielman; Richard Lee; Eckhard R Podack
Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):7063-70.
1998: Stephen J Simpson; Ype P de Jong; SA Shah; Martina Comiskey; Baoping Wang; JA Spielman; Eckhard R Podack; Emiko Mizoguchi; Atul K Bhan; Cox Terhorst
Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease.
Gastroenterology 1998;115(4):849-55.
1998: Daniel Rukavina; Gordana Laskarin; G Rubesa; Natasa Strbo; Ivica Bedenicki; D Manestar; M Glavas; Stephen E Christmas; Eckhard R Podack
Age-related decline of perforin expression in human cytotoxic T lymphocytes and natural killer cells.
Blood 1998;92(7):2410-20.
1998: Z Du; Camillo Ricordi; Luca Inverardi; Eckhard R Podack; Ricardo L Pastori
Efficient ex vivo inhibition of perforin and Fas ligand expression by chimeric tRNA-hammerhead ribozymes.
Human gene therapy 1998;9(11):1551-60.
1998: Michael Bennett; P A Taylor; M Austin; M B Baker; Lawrence B Schook; M Rutherford; Vinay Kumar; Eckhard R Podack; K M Mohler; Robert B Levy; B R Blazar
Cytokine and cytotoxic pathways of NK cell rejection of class I-deficient bone marrow grafts: influence of mouse colony environment.
International immunology 1998;10(6):785-90.
1998: M C Gilfillan; PJ Noel; Eckhard R Podack; Steven L Reiner; Craig Thompson
Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2180-7.
1997: W G Telford; S Y Nam; Eckhard R Podack; Richard A Miller
CD30-regulated apoptosis in murine CD8 T cells after cessation of TCR signals.
Cellular immunology 1997;182(2):125-36.
1997: R Uellner; Marketa Zvelebil; J Hopkins; J Jones; Lindsay K MacDougall; B P Morgan; Eckhard R Podack; Michael D Waterfield; Gillian M Griffiths
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.
The EMBO journal 1997;16(24):7287-96.
1997: Yuji Heike; M Takahashi; T Ohira; Ichiro Naruse; Seiji Hama; Yuichiro Ohe; T Kasai; Hisao Fukumoto; K J Olsen; Eckhard R Podack; Nagahiro Saijo
Genetic immunotherapy by intrapleural, intraperitoneal and subcutaneous injection of IL-2 gene-modified Lewis lung carcinoma cells.
International journal of cancer. Journal international du cancer 1997;73(6):844-9.
1997: Tohishiko Uno; Peter W Chen; Timothy G Murray; Eckhard R Podack; Bruce R Ksander
Gene transfer of the CD80 costimulatory molecule into ocular melanoma cells using a novel episomal vector.
Investigative ophthalmology & visual science 1997;38(12):2531-9.
1997: Daniel Rukavina; Eckhard R Podack; G Rubesa; S Spanjol-Pandelo; Ljiljana Randic
Down-regulated expression of perforin-positive/CD16+ cells in the peripheral blood lymphocytes in the first trimester of pregnancy and up-regulation at the end of pregnancy.
American journal of reproductive immunology (New York, N.Y. : 1989) 1997;38(3):189-96.
1997: L Gudelj; Stephen E Christmas; Gordana Laskarin; Peter M Johnson; Eckhard R Podack; Daniel Rukavina
Membrane phenotype and expression of perforin and serine esterases by CD3- peripheral blood and decidual granular lymphocyte-derived clones.
American journal of reproductive immunology (New York, N.Y. : 1989) 1997;38(3):162-7.
1997: Gordan Gulan; Eckhard R Podack; Daniel Rukavina; L Gudelj; G Rubesa; O Petrovic; Peter M Johnson; Stephen E Christmas
Perforin-expressing lymphocytes in peripheral blood and decidua of human first-trimester pathological pregnancies.
American journal of reproductive immunology (New York, N.Y. : 1989) 1997;38(1):9-18.
1997: Z Du; Camillo Ricordi; Eckhard R Podack; Ricardo L Pastori
In vitro characterization of hammerhead ribozymes against perforin and fas-ligand RNA.
Transplantation proceedings 1997;29(4):2224-5.
1997: Gennaro Selvaggi; Camillo Ricordi; Eckhard R Podack; Luca Inverardi
Mechanisms of rejection of nonvascularized grafts: the role of perforin and Fas.
Transplantation proceedings 1997;29(4):2075-6.
1997: William Stohl; J E Elliott; Lily Li; Eckhard R Podack; DH Lynch; Chaim O Jacob
Impaired nonrestricted cytolytic activity in systemic lupus erythematosus: involvement of a pathway independent of Fas, tumor necrosis factor, and extracellular ATP that is associated with little detectable perforin.
Arthritis and rheumatism 1997;40(6):1130-7.
1997: V N Ivanov; Richard Lee; Eckhard R Podack; Thomas R Malek
Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-kappa B.
Oncogene 1997;14(20):2455-64.
1997: G Rubesa; Eckhard R Podack; J Sepcić; Daniel Rukavina
Increased perforin expression in multiple sclerosis patients during exacerbation of disease in peripheral blood lymphocytes.
Journal of neuroimmunology 1997;74(1-2):198-204.
1997: T Nakamura; Richard Lee; S Y Nam; Eckhard R Podack; Kim Bottomly; Richard A Flavell
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2648-53.
1997: T Nakamura; Richard Lee; S Y Nam; Basel K al-Ramadi; Pandelakis Koni; Kim Bottomly; Eckhard R Podack; Richard A Flavell
Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2090-8.
1997: M B Baker; Richard Louis Riley; Eckhard R Podack; Robert B Levy
Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1366-71.
1997: Federica Pericle; Pearlie K Epling-Burnette; Eckhard R Podack; S Wei; Julie Y Djeu
CD40-CD40L interactions provide "third-party" costimulation for T cell response against B7-1-transfected human breast tumor cells.
Journal of leukocyte biology 1997;61(2):201-8.
1996: Gennaro Selvaggi; Camillo Ricordi; Eckhard R Podack; Luca Inverardi
The role of the perforin and Fas pathways of cytotoxicity in skin graft rejection.
Transplantation 1996;62(12):1912-5.
1996: M Nishio; J Spielman; Richard Lee; D L Nelson; Eckhard R Podack
CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4347-53.
1996: Peter W Chen; D C Geer; Eckhard R Podack; Bruce R Ksander
Tumor cells transfected with B7-1 and interleukin-12 cDNA induce protective immunity.
Annals of the New York Academy of Sciences 1996;795():325-7.
1996: Z Du; Camillo Ricordi; Eckhard R Podack; Ricardo L Pastori
A hammerhead ribozyme that cleaves perforin and fas-ligand RNAs in vitro.
Biochemical and biophysical research communications 1996;226(3):595-600.
1996: M Nishio; Eckhard R Podack
Rapid induction of tumor necrosis factor cytotoxicity in naive splenic T cells by simultaneous CD80 (B7.1) and CD54 (ICAM-1) co-stimulation.
European journal of immunology 1996;26(9):2160-4.
1996: Richard Lee; J Spielman; D Y Zhao; K J Olsen; Eckhard R Podack
Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):1919-25.
1996: Richard Lee; J Spielman; Eckhard R Podack
Bcl-2 protects against Fas-based but not perforin-based T cell-mediated cytolysis.
International immunology 1996;8(7):991-1000.
1996: M B Baker; Norman Altman; Eckhard R Podack; Robert B Levy
The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.
The Journal of experimental medicine 1996;183(6):2645-56.
1996: A Hameed; Eckhard R Podack; W M Fox; R W Schafer; M E Sherman
Detection of perforin in human peritoneal fluid T-lymphocytes.
Acta cytologica 1996;40(3):401-7.
1996: B Liu; Eckhard R Podack; James P Allison; Thomas R Malek
Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1117-25.
1996: Daniel Rukavina; S Balen-Marunic; G Rubesa; P Orlic; K Vujaklija; Eckhard R Podack
Perforin expression in peripheral blood lymphocytes in rejecting and tolerant kidney transplant recipients.
Transplantation 1996;61(2):285-91.
1996: MA Bowen; Richard Lee; G Miragliotta; S Y Nam; Eckhard R Podack
Structure and expression of murine CD30 and its role in cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):442-9.
1995: M Baker; Eckhard R Podack; Robert B Levy
Fas and perforin cytotoxic pathways are not the major effector mechanisms in allogeneic resistance to bone marrow.
Annals of the New York Academy of Sciences 1995;770():368-9.
1995: Robert B Levy; M Baker; Eckhard R Podack
Perforin-deficient T cells can induce acute graft-versus-host disease after transplantation of MHC-matched or MHC disparate allogeneic bone marrow.
Annals of the New York Academy of Sciences 1995;770():366-7.
1995: Gennaro Selvaggi; Luca Inverardi; Robert B Levy; Mathias D Brendel; J Spielman; Daniel Mintz; Eckhard R Podack; Camillo Ricordi
Abrogation of graft-versus-host disease following allotransplantation of cytotoxically deficient bone marrow across major histocompatibility barriers.
Annals of the New York Academy of Sciences 1995;770():339-44.
1995: M B Baker; Eckhard R Podack; Robert B Levy
Perforin- and Fas-mediated cytotoxic pathways are not required for allogeneic resistance to bone marrow grafts in mice.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1995;1(2):69-73.
1995: Gennaro Selvaggi; Luca Inverardi; Robert B Levy; Daniel Mintz; Eckhard R Podack; Camillo Ricordi
Tolerance induction to islet allografts following infusion of perforin deficient bone marrow.
Transplantation proceedings 1995;27(6):3193.
1995: V N Ivanov; G Deng; Eckhard R Podack; Thomas R Malek
Pleiotropic effects of Bcl-2 on transcription factors in T cells: potential role of NF-kappa B p50-p50 for the anti-apoptotic function of Bcl-2.
International immunology 1995;7(11):1709-20.
1995: G Deng; Eckhard R Podack
Deoxyribonuclease induction in apoptotic cytotoxic T lymphocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(8):665-9.
1995: Daniel Rukavina; G Rubesa; L Gudelj; H Haller; Eckhard R Podack
Characteristics of perforin expressing lymphocytes within the first trimester decidua of human pregnancy.
American journal of reproductive immunology (New York, N.Y. : 1989) 1995;33(5):394-404.
1995: A Hameed; W M Fox; Robert J Kurman; Ralph Hruban; Eckhard R Podack
Perforin expression in human cell-mediated luteolysis.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1995;14(2):151-7.
1995: A Hameed; W M Fox; Robert J Kurman; Ralph Hruban; Eckhard R Podack
Perforin expression in endometrium during the menstrual cycle.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1995;14(2):143-50.
1995: S Isaaz; K Baetz; K Olsen; Eckhard R Podack; Gillian M Griffiths
Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway.
European journal of immunology 1995;25(4):1071-9.
1995: Eckhard R Podack
Functional significance of two cytolytic pathways of cytotoxic T lymphocytes.
Journal of leukocyte biology 1995;57(4):548-52.
1995: Mathias G Lichtenheld; Eckhard R Podack; Robert B Levy
Transgenic control of perforin gene expression. Functional evidence for two separate control regions.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2153-63.
1995: Peter A Cassileth; Eckhard R Podack; K Sridhar; Niramol Savaraj; J Hanlon
Phase I study of transfected cancer cells expressing the interleukin-2 gene product in limited stage small cell lung cancer.
Human gene therapy 1995;6(3):369-83.
1995: Y Ohe; D Zhao; N Saijo; Eckhard R Podack
Construction of a novel bovine papillomavirus vector without detectable transforming activity suitable for gene transfer.
Human gene therapy 1995;6(3):325-33.
1995: Gordana Konjevic; B Schlesinger; Linzhao Cheng; K J Olsen; Eckhard R Podack; Ivan Spuzic
Analysis of perforin expression in human peripheral blood lymphocytes, CD56+ natural killer cell subsets and its induction by interleukin-2.
Immunological investigations 1995;24(3):499-507.
1995: Eckhard R Podack
Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular pathways.
Current opinion in immunology 1995;7(1):11-6.
1995: Eckhard R Podack
Perforin, killer cells and gene transfer immunotherapy for cancer.
Current topics in microbiology and immunology 1995;198():121-30.
1994: Z Wu; Eckhard R Podack; J M McKenzie; K J Olsen; M Zakarija
Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease.
Clinical and experimental immunology 1994;98(3):470-7.
1994: E P Miskovsky; A Y Liu; W Pavlat; R Viveen; P E Stanhope; Diana Finzi; W M Fox; Ralph Hruban; Eckhard R Podack; Robert Siliciano
Studies of the mechanism of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2787-99.
1994: T Ohira; Yuichiro Ohe; Yuji Heike; Eckhard R Podack; K J Olsen; Kazuto Nishio; M Nishio; Y Miyahara; Y Funayama; H Ogasawara
Gene therapy for Lewis lung carcinoma with tumor necrosis factor and interleukin 2 cDNAs co-transfected subline.
Gene therapy 1994;1(4):269-75.
1994: D Kägi; Birgit Ledermann; K Bürki; P Seiler; B Odermatt; K J Olsen; Eckhard R Podack; Rolf M Zinkernagel; Hans Hengartner
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice.
Nature 1994;369(6475):31-7.
1994: M Lopez-Cepero; Jose A. Garcia-Sanz; L Herbert; Richard Louis Riley; M E Handel; Eckhard R Podack; Diana M Lopez
Soluble and membrane-bound TNF-alpha are involved in the cytotoxic activity of B cells from tumor-bearing mice against tumor targets.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3333-41.
1994: T Ohira; Yuichiro Ohe; Yuji Heike; Eckhard R Podack; K J Olsen; Kazuto Nishio; M Nishio; Y Miyahara; Y Funayama; H Ogasawara
In vitro and in vivo growth of B16F10 melanoma cells transfected with interleukin-4 cDNA and gene therapy with the transfectant.
Journal of cancer research and clinical oncology 1994;120(11):631-5.
1993: Michael A Bowen; K J Olsen; Linzhao Cheng; D Avila; Eckhard R Podack
Functional effects of CD30 on a large granular lymphoma cell line, YT. Inhibition of cytotoxicity, regulation of CD28 and IL-2R, and induction of homotypic aggregation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):5896-906.
1993: J A García-Sanz; Eckhard R Podack
Regulation of perforin gene expression in a T cell hybrid with inducible cytolytic activity.
European journal of immunology 1993;23(8):1877-83.
1993: Yuichiro Ohe; Eckhard R Podack; K J Olsen; Y Miyahara; K Miura; H Saito; Y Koishihara; Y Ohsugi; T Ohira; Kazuto Nishio
Interleukin-6 cDNA transfected Lewis lung carcinoma cells show unaltered net tumour growth rate but cause weight loss and shortened survival in syngeneic mice.
British journal of cancer 1993;67(5):939-44.
1993: T Ohmori; Eckhard R Podack; Kazuto Nishio; M Takahashi; Y Miyahara; Y Takeda; N Kubota; Y Funayama; H Ogasawara; T Ohira
Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2.
Biochemical and biophysical research communications 1993;192(1):30-6.
1993: G Deng; Eckhard R Podack
Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2189-93.
1993: Yuichiro Ohe; Eckhard R Podack; K J Olsen; Y Miyahara; T Ohira; K Miura; Kazuto Nishio; Nagahiro Saijo
Combination effect of vaccination with IL2 and IL4 cDNA transfected cells on the induction of a therapeutic immune response against Lewis lung carcinoma cells.
International journal of cancer. Journal international du cancer 1993;53(3):432-7.
1992: Mathias G Lichtenheld; Eckhard R Podack
Structure and function of the murine perforin promoter and upstream region. Reciprocal gene activation or silencing in perforin positive and negative cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2619-26.
1992: Robert W Keane; M W Tallent; Eckhard R Podack
Resistance and susceptibility of neural cells to lysis by cytotoxic lymphocytes and by cytolytic granules.
Transplantation 1992;54(3):520-6.
1992: P Lu; Jose A. Garcia-Sanz; Mathias G Lichtenheld; Eckhard R Podack
Perforin expression in human peripheral blood mononuclear cells. Definition of an IL-2-independent pathway of perforin induction in CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(11):3354-60.
1992: A Hameed; K J Olsen; Linzhao Cheng; W M Fox; Ralph Hruban; Eckhard R Podack
Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody.
The American journal of pathology 1992;140(5):1025-30.
1992: P J Nelson; R L Geller; Eckhard R Podack; F H Bach
Molecular events in late stages of T-cell functional maturation.
Scandinavian journal of immunology 1992;35(3):311-20.
1992: Eckhard R Podack
Perforin: structure, function, and regulation.
Current topics in microbiology and immunology 1992;178():175-84.
1991: M V Clément; P Haddad; A Soulié; C Benvenuti; Mathias G Lichtenheld; Eckhard R Podack; N Sigaux; Marilyne Sasportes
Perforin and granzyme B as markers for acute rejection in heart transplantation.
International immunology 1991;3(11):1175-81.
1991: Eckhard R Podack; H Hengartner; Mathias G Lichtenheld
A central role of perforin in cytolysis?
Annual review of immunology 1991;9():129-57.
1991: Eckhard R Podack; Abraham Kupfer
T-cell effector functions: mechanisms for delivery of cytotoxicity and help.
Annual review of cell biology 1991;7():479-504.
1990: S Meri; B P Morgan; Mark G Wing; J Jones; A Davies; Eckhard R Podack; Peter Lachmann
Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis.
The Journal of experimental medicine 1990;172(1):367-70.
1990: E Asch; Eckhard R Podack
Vitronectin binds to activated human platelets and plays a role in platelet aggregation.
The Journal of clinical investigation 1990;85(5):1372-8.
1989: Mathias G Lichtenheld; Eckhard R Podack
Structure of the human perforin gene. A simple gene organization with interesting potential regulatory sequences.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):4267-74.
1989: C Nagler-Anderson; Mathias G Lichtenheld; Herman N Eisen; Eckhard R Podack
Perforin mRNA in primary peritoneal exudate cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3440-3.
1989: Eckhard R Podack
Killer lymphocytes and how they kill.
Current opinion in cell biology 1989;1(5):929-33.
1989: F H Bach; R L Geller; P J Nelson; S Panzer; G Gromo; Mark R Benfield; Luca Inverardi; Eckhard R Podack; J C Witson; J P Houchins
A "minimal signal-stepwise activation" analysis of functional maturation of T lymphocytes.
Immunological reviews 1989;111():35-57.
1989: C Müller; D Kägi; T Aebischer; B Odermatt; W Held; Eckhard R Podack; Rolf M Zinkernagel; Hans Hengartner
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
European journal of immunology 1989;19(7):1253-9.
1989: A Hameed; K J Olsen; M K Lee; Mathias G Lichtenheld; Eckhard R Podack
Cytolysis by Ca-permeable transmembrane channels. Pore formation causes extensive DNA degradation and cell lysis.
The Journal of experimental medicine 1989;169(3):765-77.
1989: M Hoffman; Abraham Mittelman; B Dworkin; W Rosenthal; Debra Beneck; E Gafney; Z Arlin; D Levitt; Eckhard R Podack
Severe intrahepatic cholestasis in patients treated with recombinant interleukin-2 and lymphokine-activated killer cells.
Journal of cancer research and clinical oncology 1989;115(2):175-8.
1989: D M Lowrey; T Aebischer; K Olsen; Mathias G Lichtenheld; F Rupp; H Hengartner; Eckhard R Podack
Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):247-51.
1989: Eckhard R Podack; H Hengartner
Structure of perforin and its role in cytolysis.
The Year in immunology 1989;6():245-61.
1989: Eckhard R Podack; K J Olsen; D M Lowrey; Mathias G Lichtenheld
Structure and function of perforin.
Current topics in microbiology and immunology 1989;140():11-7.
1989: Eckhard R Podack
Granule-mediated cytolysis of target cells.
Current topics in microbiology and immunology 1989;140():1-9.
1989: Joao L Ascensao; S J Liu; J Caro; Eckhard R Podack; A Mittelman; Esmail D Zanjani; Y L Zhao
Erythropoiesis in cancer patients undergoing immunotherapy.
Advances in experimental medicine and biology 1989;271():197-204.
1989: K P Preissner; Eckhard R Podack; H J Müller-Eberhard
SC5b-7, SC5b-8 and SC5b-9 complexes of complement: ultrastructure and localization of the S-protein (vitronectin) within the macromolecules.
European journal of immunology 1989;19(1):69-75.
1988: A Hameed; D M Lowrey; Mathias G Lichtenheld; Eckhard R Podack
Characterization of three serine esterases isolated from human IL-2 activated killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(9):3142-7.
1988: Mathias G Lichtenheld; K J Olsen; P Lu; D M Lowrey; A Hameed; H Hengartner; Eckhard R Podack
Structure and function of human perforin.
Nature 1988;335(6189):448-51.
1988: D M Lowrey; A Hameed; Mathias G Lichtenheld; Eckhard R Podack
Isolation and characterization of cytotoxic granules from human lymphokine (interleukin 2) activated killer cells.
Cancer research 1988;48(16):4681-8.
1988: Eckhard R Podack; D M Lowrey; Mathias G Lichtenheld; K J Olsen; T Aebischer; D Binder; F Rupp; H Hengartner
Structure, function and expression of murine and human perforin 1 (P1).
Immunological reviews 1988;103():203-11.
1988: Eckhard R Podack; D M Lowrey; Mathias G Lichtenheld; A Hameed
Function of granule perforin and esterases in T cell-mediated reactions. Components required for delivery of molecules to target cells.
Annals of the New York Academy of Sciences 1988;532():292-302.
1987: H Koren; R Goldfarb; P Henkart; C Bleackley; B Bonavida; G Granger; M Palladino; Eckhard R Podack; C Reynolds; N Ruddle
Proposal for classification of leukocyte-associated cytolytic molecules: Denver, Colorado, September 28, 1986.
Journal of leukocyte biology 1987;41(5):447-9.
1987: P Groscurth; B Y Qiao; Eckhard R Podack; H Hengartner
Cellular localization of perforin 1 in murine cloned cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(9):2749-52.
1987: R J Falk; Eckhard R Podack; A P Dalmasso; John Jennette
Localization of S protein and its relationship to the membrane attack complex of complement in renal tissue.
The American journal of pathology 1987;127(1):182-90.
1987: D M Lowrey; F Rupp; T Aebischer; P Grey; H Hengartner; Eckhard R Podack
Primary sequence homology between the effector molecules that mediate complement and T-lymphocyte cytotoxicity.
Annales de l'Institut Pasteur. Immunology 1987;138(2):296-300.
1987: Eckhard R Podack; K O Penichet; B Y Lin; J W Chiao; A Mittelman
Increased cytotoxicity and CD16 (Leu 11) expression in long-term, IL-2-activated human peripheral blood mononuclear cells.
Blood cells 1987;13(1-2):117-22.
1987: S J Liu; J L Ascensão; Eckhard R Podack; B Y Lin; Z Arlin; JD Lutton; E Gafney; Paul Baskind; Abraham Mittelman
Cellular interactions in hemopoiesis.
Blood cells 1987;13(1-2):101-10.
1986: J D Young; Z A Cohn; Eckhard R Podack
The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities.
Science (New York, N.Y.) 1986;233(4760):184-90.
1986: J D Young; Eckhard R Podack; Z A Cohn
Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules.
The Journal of experimental medicine 1986;164(1):144-55.
1986: Eckhard R Podack; B Dahlbäck; J H Griffin
Interaction of S-protein of complement with thrombin and antithrombin III during coagulation. Protection of thrombin by S-protein from antithrombin III inactivation.
The Journal of biological chemistry 1986;261(16):7387-92.
1986: J D Young; H Hengartner; Eckhard R Podack; Z A Cohn
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity.
Cell 1986;44(6):849-59.
1986: Eckhard R Podack
Molecular mechanisms of cytolysis by complement and by cytolytic lymphocytes.
Journal of cellular biochemistry 1986;30(2):133-70.
1986: J D Young; C F Nathan; Eckhard R Podack; M A Palladino; Z A Cohn
Functional channel formation associated with cytotoxic T-cell granules.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(1):150-4.
1985: Eckhard R Podack; J D Young; Z A Cohn
Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8629-33.
1985: K T Pressner; Eckhard R Podack; H J Müller-Eberhard
Self-association of the seventh component of human complement (C7): dimerization and polymerization.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(1):452-8.
1985: K T Preissner; Eckhard R Podack; H J Müller-Eberhard
The membrane attack complex of complement: relation of C7 to the metastable membrane binding site of the intermediate complex C5b-7.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(1):445-51.
1985: B Dahlbäck; Eckhard R Podack
Characterization of human S protein, an inhibitor of the membrane attack complex of complement. Demonstration of a free reactive thiol group.
Biochemistry 1985;24(9):2368-74.
1985: J Tschopp; Eckhard R Podack; H J Müller-Eberhard
The membrane attack complex of complement: C5b-8 complex as accelerator of C9 polymerization.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(1):495-9.
1985: Eckhard R Podack; P J Konigsberg; H Acha-Orbea; H Pircher; H Hengartner
Cytolytic T-cell granules: biochemical properties and functional specificity.
Advances in experimental medicine and biology 1985;184():99-119.
1984: R G DiScipio; M R Gehring; Eckhard R Podack; C C Kan; T E Hugli; Georg H Fey
Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7298-302.
1984: Eckhard R Podack; P J Konigsberg
Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.
The Journal of experimental medicine 1984;160(3):695-710.
1984: Eckhard R Podack
Molecular composition of the tubular structure of the membrane attack complex of complement.
The Journal of biological chemistry 1984;259(13):8641-7.
1984: Eckhard R Podack; J Tschopp
Membrane attack by complement.
Molecular immunology 1984;21(7):589-603.
1984: J Tschopp; A Engel; Eckhard R Podack
Molecular weight of poly(C9). 12 to 18 C9 molecules form the transmembrane channel of complement.
The Journal of biological chemistry 1984;259(3):1922-8.
1984: Eckhard R Podack; K T Preissner; H J Müller-Eberhard
Inhibition of C9 polymerization within the SC5b-9 complex of complement by S-protein.
Acta pathologica, microbiologica, et immunologica Scandinavica. Supplement 1984;284():89-96.
1983: G Dennert; Eckhard R Podack
Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes.
The Journal of experimental medicine 1983;157(5):1483-95.
1983: C W Vogel; A Plückthun; Eckhard R Podack; E A Dennis; H J Müller-Eberhard
The membrane attack complex of complement and its precursor proteins lack phospholipase activity.
Molecular immunology 1983;20(4):377-82.
1983: Eckhard R Podack; G Dennert
Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells.
Nature 1983;302(5907):442-5.
1982: Eckhard R Podack; J Tschopp
Circular polymerization of the ninth component of complement. Ring closure of the tubular complex confers resistance to detergent dissociation and to proteolytic degradation.
The Journal of biological chemistry 1982;257(24):15204-12.
1982: J Tschopp; Eckhard R Podack; H J Müller-Eberhard
Ultrastructure of the membrane attack complex of complement: detection of the tetramolecular C9-polymerizing complex C5b-8.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(23):7474-8.
1982: G R Harriman; Eckhard R Podack; A I Braude; L C Corbeil; A F Esser; J G Curd
Activation of complement by serum-resistant Neisseria gonorrhoeae. Assembly of the membrane attack complex without subsequent cell death.
The Journal of experimental medicine 1982;156(4):1235-49.
1982: J Tschopp; H J Müller-Eberhard; Eckhard R Podack
Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9.
Nature 1982;298(5874):534-8.
1982: Eckhard R Podack; J Tschoop; H J Müller-Eberhard
Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly.
The Journal of experimental medicine 1982;156(1):268-82.
1982: Eckhard R Podack; H J Müller-Eberhard; H Horst; W Hoppe
Membrane attach complex of complement (MAC): three-dimensional analysis of MAC-phospholipid vesicle recombinants.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(5):2353-7.
1982: Eckhard R Podack; J Tschopp
Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(2):574-8.
1981: G R Harriman; A F Esser; Eckhard R Podack; A C Wunderlich; A I Braude; T F Lint; J G Curd
The role of C9 in complement-mediated killing of Neisseria.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(6):2386-90.
1981: V W Hu; A F Esser; Eckhard R Podack; B J Wisnieski
The membrane attack mechanism of complement: photolabeling reveals insertion of terminal proteins into target membrane.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(1):380-6.
1981: Eckhard R Podack; W Stoffel; A F Esser; H J Müller-Eberhard
Membrane attack complex of complement: distribution of subunits between the hydrocarbon phase of target membranes and water.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4544-8.
1981: J Tschopp; Eckhard R Podack
Membranolysis by the ninth component of human complement.
Biochemical and biophysical research communications 1981;100(3):1409-14.
1981: W Horn; W Opferkuch; Eckhard R Podack
Suppression of the anti-erythrocyte immune response in mice by the C5b--9 complex of complement.
Immunology 1981;43(2):303-9.
1981: Eckhard R Podack; H J Müller-Eberhard
Membrane attack complex of complement. Evidence for its dimeric structure based on hybrid formation.
The Journal of biological chemistry 1981;256(7):3145-8.
1980: Eckhard R Podack; H J Müller-Eberhard
SC5b-9 complex of complement: formation of the dimeric membrane attack complex by removal of S-protein.
Journal of immunology (Baltimore, Md. : 1950) 1980;124(4):1779-83.
1980: Eckhard R Podack; A F Esser; G Biesecker; H J Müller-Eberhard
Membrane attack complex of complement: a structural analysis of its assembly.
The Journal of experimental medicine 1980;151(2):301-13.
1980: D E Isenman; Eckhard R Podack; N R Cooper
The interaction of C5 with C3b in free solution: a sufficient condition for cleavage by a fluid phase C3/C5 convertase.
Journal of immunology (Baltimore, Md. : 1950) 1980;124(1):326-31.
1980: Eckhard R Podack; H J Müller-Eberhard
Limited proteolysis of C5b-6: functional stability of the degraded complex.
Journal of immunology (Baltimore, Md. : 1950) 1980;124(1):332-6.
1979: Eckhard R Podack; H J Müller-Eberhard
Isolation of human S-protein, an inhibitor of the membrane attack complex of complement.
The Journal of biological chemistry 1979;254(19):9808-14.
1979: Eckhard R Podack; W P Kolb; A F Esser; H J Müller-Eberhard
Structural similarities between C6 and C7 of human complement.
Journal of immunology (Baltimore, Md. : 1950) 1979;123(3):1071-7.
1979: J Bauer; Eckhard R Podack; G Valet
Determination of the number of lytic sites in biconcave and spheroid erythrocyte ghosts after complement lysis.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(5):2032-6.
1979: W P Kolb; L M Kolb; Eckhard R Podack
C1q: isolation from human serum in high yield by affinity chromatography and development of a highly sensitive hemolytic assay.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(5):2103-11.
1979: R D Schreiber; D C Morrison; Eckhard R Podack; H J Müller-Eberhard
Bactericidal activity of the alternative complement pathway generated from 11 isolated plasma proteins.
The Journal of experimental medicine 1979;149(4):870-82.
1979: A F Esser; W P Kolb; Eckhard R Podack; H J Müller-Eberhard
Molecular reorganization of lipid bilayers by complement: a possible mechanism for membranolysis.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(3):1410-4.
1979: G Biesecker; Eckhard R Podack; C A Halverson; H J Müller-Eberhard
C5b-9 dimer: isolation from complement lysed cells and ultrastructural identification with complement-dependent membrane lesions.
The Journal of experimental medicine 1979;149(2):448-58.
1979: Eckhard R Podack; G Biesecker; H J Müller-Eberhard
Membrane attack complex of complement: generation of high-affinity phospholipid binding sites by fusion of five hydrophilic plasma proteins.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(2):897-901.
1979: R M Bartholomew; Eckhard R Podack; A F Esser
Quantitation of the membrane attack complex of complement in an air-driven ultracentrifuge.
Journal of immunological methods 1979;31(3-4):351-60.
1978: Eckhard R Podack; H J Müller-Eberhard
Binding of desoxycholate, phosphatidylcholine vesicles, lipoprotein and of the S-protein to complexes of terminal complement components.
Journal of immunology (Baltimore, Md. : 1950) 1978;121(3):1025-30.
1978: Eckhard R Podack; G Biesecker; W P Kolb; H J Müller-Eberhard
The C5b-6 complex: reaction with C7, C8, C9.
Journal of immunology (Baltimore, Md. : 1950) 1978;121(2):484-90.
1978: Eckhard R Podack; W P Kolb; H J Müller-Eberhard
The C5b-6 complex: formation, isolation, and inhibition of its activity by lipoprotein and the S-protein of human serum.
Journal of immunology (Baltimore, Md. : 1950) 1978;120(6):1841-8.
1977: Eckhard R Podack; W P Kolb; H J Müller-Eberhard
The SC5b-7 complex: formation, isolation, properties, and subunit composition.
Journal of immunology (Baltimore, Md. : 1950) 1977;119(6):2024-9.
1976: Eckhard R Podack; W P Kolb; H J Muller-Eberhard
The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex.
Journal of immunology (Baltimore, Md. : 1950) 1976;116(5):1431-4.
1976: Eckhard R Podack; W P Kolb; H J Müller-Eberhard
Purification of the sixth and seventh component of human complement without loss of hemolytic activity.
Journal of immunology (Baltimore, Md. : 1950) 1976;116(2):263-9.
1974: Eckhard R Podack; G Saathoff
On the mechanism and control of the malonyl-CoA-dependent chain elongation of fatty acids. The malonyl-transfer reaction.
European journal of biochemistry / FEBS 1974;50(1):237-43.
1974: W Seubert; Eckhard R Podack; G Saathoff
Proceedings: Mechanism of microsomal chain elongation of fatty acids.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1974;355(10):1255-6.
1974: Eckhard R Podack; M Lakomek; G Saathoff; W Seubert
On the mechanism and control of the malonyl-CoA-dependent chain elongation of fatty acids. Characterization of hexenoyl-CoA reductase from liver and adrenal cortex as a constituent of the microsomal chain elongation.
European journal of biochemistry / FEBS 1974;45(1):13-23.
1973: W Seubert; Eckhard R Podack
Mechanisms and physiological roles of fatty acid chain elongation in microsomes and mitochondria.
Molecular and cellular biochemistry 1973;1(1):29-40.
1972: Eckhard R Podack; W Seubert
On the mechanism of malonyl-CoA independent fatty acid synthesis. II. Isolation, properties and subcellular location of trans-2,3-hexenoyl-CoA and trans-2,3-decenoyl-CoA reductase.
Biochimica et biophysica acta 1972;280(2):235-47.
1972: Eckhard R Podack; W Seubert
[2,3-trans-Hexenoyl-CoA-reductase and 2,3-trans-decenoyl-CoA-reductase as components of microsomal, malonyl-CoA-dependent or mitochondrial acetyl CoA dependent chain prolongation of fatty acids].
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1972;353(10):1557.
1972: Eckhard R Podack; W Seubert
[Isolation, subcellular localization, properties and physiological significance of 2,3-trans-decenyl-CoA-reductase from rat liver].
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1972;353(5):744-5.