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Alberto Podjarny

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Procedures

Phenomena

Genes & Molecular Sequences

Molecular Structure

Occupations

Drug Design

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Co-Publications
Name
19
Mitschler, Andre
12
Hazemann, Isabelle
11
Moras, Dino
11
Joachimiak, Andrzej
10
Urzhumtsev, Alexandre
9
El-Kabbani, Ossama
8
Barth, P
7
Lunin, Vladimir
7
Petrova, Tatiana
7
Van Zandt, Michael
5
Van Dorsselaer, Alain
5
Darmanin, Connie
4
Biellmann, Jean-François
4
Oka, Mitsuru
4
Lunina, Natalia

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Publications

TOP 3
Fournier Bertrand; Bendeif El-Eulmi; Guillot Benoît; Podjarny Alberto; Lecomte Claude; Jelsch Christian
Charge density and electrostatic interactions of fidarestat, an inhibitor of human aldose reductase.
Van Zandt Michael C; Doan Brian; Sawicki Diane R; Sredy Janet; Podjarny Alberto D
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Petrova Tatiana; Lunin Vladimir Y; Ginell Stephan; Hazemann Isabelle; Lazarski Krzysztof; Mitschler André; Podjarny Alberto; Joachimiak Andrzej
X-ray-radiation-induced cooperative atomic movements in protein.

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All Publications

2009: Fournier Bertrand; Bendeif El-Eulmi; Guillot Benoît; Podjarny Alberto; Lecomte Claude; Jelsch Christian
Charge density and electrostatic interactions of fidarestat, an inhibitor of human aldose reductase.
Journal of the American Chemical Society 2009;131(31):10929-41.
2009: Van Zandt Michael C; Doan Brian; Sawicki Diane R; Sredy Janet; Podjarny Alberto D
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Bioorganic & medicinal chemistry letters 2009;19(7):2006-8.
2009: Petrova Tatiana; Lunin Vladimir Y; Ginell Stephan; Hazemann Isabelle; Lazarski Krzysztof; Mitschler André; Podjarny Alberto; Joachimiak Andrzej
X-ray-radiation-induced cooperative atomic movements in protein.
Journal of molecular biology 2009;387(5):1092-105.
2008: Blakeley Matthew P; Langan Paul; Niimura Nobuo; Podjarny Alberto
Neutron crystallography: opportunities, challenges, and limitations.
Current opinion in structural biology 2008;18(5):593-600.
2008: Steuber Holger; Heine Andreas; Podjarny Alberto; Klebe Gerhard
Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
Journal of molecular biology 2008;379(5):991-1016.
2008: Guillot Benoît; Jelsch Christian; Podjarny Alberto; Lecomte Claude
Charge-density analysis of a protein structure at subatomic resolution: the human aldose reductase case.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 5):567-88.
2008: Zhao Hai-Tao; Hazemann Isabelle; Mitschler Andre; Carbone Vincenzo; Joachimiak Andrzej; Ginell Steve; Podjarny Alberto; El-Kabbani Ossama
Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: implications for the inhibition mechanism.
Journal of medicinal chemistry 2008;51(5):1478-81.
2008: Blakeley Matthew P; Ruiz Federico; Cachau Raul; Hazemann Isabelle; Meilleur Flora; Mitschler Andre; Ginell Stephan; Afonine Pavel; Ventura Oscar N; Cousido-Siah Alexandra; Haertlein Michael; Joachimiak Andrzej; Myles Dean; Podjarny Alberto
Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):1844-8.
2007: El-Kabbani O; Podjarny A
Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites.
Cellular and molecular life sciences : CMLS 2007;64(15):1970-8.
2007: Biadene Marianna; Hazemann Isabelle; Cousido Alexandra; Ginell Steve; Joachimiak Andrzej; Sheldrick George M; Podjarny Alberto; Schneider Thomas R
The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 6):665-72.
2006: Petrova Tatiana; Ginell Stephan; Mitschler Andre; Hazemann Isabelle; Schneider Thomas; Cousido Alexandra; Lunin Vladimir Y; Joachimiak Andrzej; Podjarny Alberto
Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 12):1535-44.
2006: Blakeley M P; Mitschler A; Hazemann I; Meilleur F; Myles D A A; Podjarny A
Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase-inhibitor complex.
European biophysics journal : EBJ 2006;35(7):577-83.
2006: Steuber Holger; Zentgraf Matthias; Podjarny Alberto; Heine Andreas; Klebe Gerhard
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group.
Journal of molecular biology 2006;356(1):45-56.
2005: Marquardt Tobias; Kostrewa Dirk; Balakrishnan Rajkumar; Gasperina Antonietta; Kambach Christian; Podjarny Alberto; Winkler Fritz K; Balendiran Ganesaratnam K; Li Xiao-Dan
High-resolution crystal structure of AKR11C1 from Bacillus halodurans: an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Journal of molecular biology 2005;354(2):304-16.
2005: Hazemann I; Dauvergne M T; Blakeley M P; Meilleur F; Haertlein M; Van Dorsselaer A; Mitschler A; Myles D A A; Podjarny A
High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1413-7.
2005: Petrova Tatiana; Steuber Holger; Hazemann Isabelle; Cousido-Siah Alexandra; Mitschler Andre; Chung Roland; Oka Mitsuru; Klebe Gerhard; El-Kabbani Ossama; Joachimiak Andrzej; Podjarny Alberto
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.
Journal of medicinal chemistry 2005;48(18):5659-65.
2005: El-Kabbani Ossama; Carbone Vincenzo; Darmanin Connie; Oka Mitsuru; Mitschler Andre; Podjarny Alberto; Schulze-Briese Clemens; Chung Roland P-T
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
Journal of medicinal chemistry 2005;48(17):5536-42.
2005: Van Zandt Michael C; Jones Michael L; Gunn David E; Geraci Leo S; Jones J Howard; Sawicki Diane R; Sredy Janet; Jacot Jorge L; Dicioccio A Thomas; Petrova Tatiana; Mitschler Andre; Podjarny Alberto D
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Journal of medicinal chemistry 2005;48(9):3141-52.
2005: Cachau R E; Podjarny A D
High-resolution crystallography and drug design.
Journal of molecular recognition : JMR 2005;18(3):196-202.
2004: Van Zandt Michael C; Sibley Evelyn O; McCann Erin E; Combs Kerry J; Flam Brenda; Sawicki Diane R; Sabetta Al; Carrington Anne; Sredy Janet; Howard Eduardo; Mitschler Andre; Podjarny Alberto D
Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications.
Bioorganic & medicinal chemistry 2004;12(21):5661-75.
2004: El-Kabbani Ossama; Darmanin Connie; Oka Mitsuru; Schulze-Briese Clemens; Tomizaki Takashi; Hazemann Isabelle; Mitschler Andre; Podjarny Alberto
High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.
Journal of medicinal chemistry 2004;47(18):4530-7.
2004: Ruiz Federico; Hazemann Isabelle; Mitschler Andre; Joachimiak Andrzejj; Schneider Thomas; Karplus Martin; Podjarny Alberto
The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 8):1347-54.
2004: Darmanin Connie; Chevreux Guillaume; Potier Noelle; Van Dorsselaer Alain; Hazemann Isabelle; Podjarny Alberto; El-Kabbani Ossama
Probing the ultra-high resolution structure of aldose reductase with molecular modelling and noncovalent mass spectrometry.
Bioorganic & medicinal chemistry 2004;12(14):3797-806.
2004: Kraemer Oliver; Hazemann Isabelle; Podjarny Alberto D; Klebe Gerhard
Virtual screening for inhibitors of human aldose reductase.
Proteins 2004;55(4):814-23.
2004: El-Kabbani Ossama; Darmanin Connie; Schneider Thomas R; Hazemann Isabelle; Ruiz Federico; Oka Mitsuru; Joachimiak Andrzejj; Schulze-Briese Clemens; Tomizaki Takashi; Mitschler Andre; Podjarny Alberto
Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors.
Proteins 2004;55(4):805-13.
2004: Howard E I; Sanishvili R; Cachau R E; Mitschler A; Chevrier B; Barth P; Lamour V; Van Zandt M; Sibley E; Bon C; Moras D; Schneider T R; Joachimiak A; Podjarny A
Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A.
Proteins 2004;55(4):792-804.
2004: Podjarny A; Cachau R E; Schneider T; Van Zandt M; Joachimiak A
Subatomic and atomic crystallographic studies of aldose reductase: implications for inhibitor binding.
Cellular and molecular life sciences : CMLS 2004;61(7-8):763-73.
2003: El-Kabbani Ossama; Ramsland Paul; Darmanin Connie; Chung Roland P-T; Podjarny Alberto
Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme.
Proteins 2003;50(2):230-8.
2003: Podjarny Alberto; Schneider Thomas R; Cachau Raul E; Joachimiak Andrzej
Structural information content at high resolution: MAD versus native.
Methods in enzymology 2003;374():321-41.
2001: Lunin V Y; Lunina N L; Ritter S; Frey I; Berg A; Diederichs K; Podjarny A D; Urzhumtsev A; Baumstark M W
Low-resolution data analysis for low-density lipoprotein particle.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 1):108-21.
2000: El-Kabbani O; Rogniaux H; Barth P; Chung R P; Fletcher E V; Van Dorsselaer A; Podjarny A
Aldose and aldehyde reductases: correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site.
Proteins 2000;41(3):407-14.
2000: Petrova T E; Lunin V Y; Podjarny A D
Ab initio low-resolution phasing in crystallography of macromolecules by maximization of likelihood.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 10):1245-52.
2000: Urzhumtsev A G; Lunina N L; Skovoroda T P; Podjarny A D; Lunin V Y
Density constraints and low-resolution phasing.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 10):1233-44.
2000: Lunin V Y; Lunina N L; Petrova T E; Skovoroda T P; Urzhumtsev A G; Podjarny A D
Low-resolution ab initio phasing: problems and advances.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 10):1223-32.
2000: Calderone V; Chevrier B; Van Zandt M; Lamour V; Howard E; Poterszman A; Barth P; Mitschler A; Lu J; Dvornik D M; Klebe G; Kraemer O; Moorman A R; Moras D; Podjarny A
The structure of human aldose reductase bound to the inhibitor IDD384.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 5):536-40.
1999: Rogniaux H; Van Dorsselaer A; Barth P; Biellmann J F; Barbanton J; van Zandt M; Chevrier B; Howard E; Mitschler A; Potier N; Urzhumtseva L; Moras D; Podjarny A
Binding of aldose reductase inhibitors: correlation of crystallographic and mass spectrometric studies.
Journal of the American Society for Mass Spectrometry 1999;10(7):635-47.
1999: Lamour V; Barth P; Rogniaux H; Poterszman A; Howard E; Mitschler A; Van Dorsselaer A; Podjarny A; Moras D
Production of crystals of human aldose reductase with very high resolution diffraction.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 3):721-3.
1998: Lunin V Y; Lunina N L; Petrova T E; Urzhumtsev A G; Podjarny A D
On the ab initio solution of the phase problem or macromolecules at very low resolution. II. Generalized likelihood based approach to cluster discrimination.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):726-34.
1997: Podjarny A D; Howard E I; Urzhumtsev A; Grigera J R
A multicopy modeling of the water distribution in macromolecular crystals.
Proteins 1997;28(3):303-12.
1997: Urzhumtsev A; Tête-Favier F; Mitschler A; Barbanton J; Barth P; Urzhumtseva L; Biellmann J F; Podjarny A; Moras D
A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
Structure (London, England : 1993) 1997;5(5):601-12.
1996: Urzhumtsev A G; Vernoslova E A; Podjarny A D
Approaches to very low resolution phasing of the ribosome 50S particle from Thermus thermophilus by the few-atoms-models and molecular-replacement methods.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 6):1092-7.
1996: Podjarny A D; Rees B; Urzhumtsev A G
Density modification in x-ray crystallography.
Methods in molecular biology (Clifton, N.J.) 1996;56():205-26.
1995: Lunin V Y; Lunina N L; Petrova T E; Vernoslova E A; Urzhumtsev A G; Podjarny A D
On the ab initio solution of the phase problem for macromolecules at very low resolution: the few atoms model method.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 6):896-903.
1995: Urzhumtsev A; Podjarny A
On the solution of the molecular-replacement problem at very low resolution: application to large complexes.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 6):888-95.
1993: Tête-Favier F; Rondeau J M; Podjarny A; Moras D
Structure determination of aldose reductase: joys and traps of local symmetry averaging.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 2):246-56.
1992: Cura V; Krishnaswamy S; Podjarny A D
Heavy-atom refinement against solvent-flattened phases.
Acta crystallographica. Section A, Foundations of crystallography 1992;48 ( Pt 5)():756-64.
1992: Rondeau J M; Tête-Favier F; Podjarny A; Reymann J M; Barth P; Biellmann J F; Moras D
Novel NADPH-binding domain revealed by the crystal structure of aldose reductase.
Nature 1992;355(6359):469-72.
1991: Ruff M; Krishnaswamy S; Boeglin M; Poterszman A; Mitschler A; Podjarny A; Rees B; Thierry J C; Moras D
Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp).
Science (New York, N.Y.) 1991;252(5013):1682-9.
1991: Rondeau J M; Moras D; Tête F; Podjarny A; Van Dorsselaer A; Reymann J M; Barth P; Biellmann J F
Structural studies of pig lens aldose reductase: reversible dimerization of the enzyme.
Advances in experimental medicine and biology 1991;284():113-8.
1989: Dock-Bregeon A C; Chevrier B; Podjarny A; Johnson J; de Bear J S; Gough G R; Gilham P T; Moras D
Crystallographic structure of an RNA helix: [U(UA)6A]2.
Journal of molecular biology 1989;209(3):459-74.
1988: Dock-Bregeon A C; Chevrier B; Podjarny A; Moras D; deBear J S; Gough G R; Gilham P T; Johnson J E
High resolution structure of the RNA duplex [U(U-A)6A]2.
Nature 1988;335(6188):375-8.
1987: Podjarny A; Rees B; Thierry J C; Cavarelli J; Jésior J C; Roth M; Lewitt-Bentley A; Kahn R; Lorber B; Ebel J P
Yeast tRNA(Asp)-aspartyl-tRNA synthetase complex: low resolution crystal structure.
Journal of biomolecular structure & dynamics 1987;5(2):187-98.

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