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Klaas Poelstra

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Marike Marjolijn van Beuge; Leonie Beljaars; Marie Lacombe; Eduard Post; Jai Prakash; Catharina Reker-Smit; Klaas Poelstra
Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury.
Sabine Klein; Klaas Poelstra; Tilman Sauerbruch; Robert Schierwagen; Leonie Beljaars; Michaela Granzow; Iren Heidari; Sebastian Huss; Sibel Kilic; Marike Marjolijn Van Beuge; Jonel Trebicka
HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects.
Ruchi Bansal; Arne Ostman; Klaas Poelstra; Tushar Tomar; Jai Prakash
Selective targeting of interferon γ to stromal fibroblasts and pericytes as a novel therapeutic approach to inhibit angiogenesis and tumor growth.

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2013: Marike Marjolijn van Beuge; Leonie Beljaars; Marie Lacombe; Eduard Post; Jai Prakash; Catharina Reker-Smit; Klaas Poelstra
Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury.
PloS one 2013;8(2):e56442.
2012: Sabine Klein; Klaas Poelstra; Tilman Sauerbruch; Robert Schierwagen; Leonie Beljaars; Michaela Granzow; Iren Heidari; Sebastian Huss; Sibel Kilic; Marike Marjolijn Van Beuge; Jonel Trebicka
HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects.
Journal of hepatology 2012;57(6):1220-7.
2012: Ruchi Bansal; Arne Ostman; Klaas Poelstra; Tushar Tomar; Jai Prakash
Selective targeting of interferon γ to stromal fibroblasts and pericytes as a novel therapeutic approach to inhibit angiogenesis and tumor growth.
Molecular cancer therapeutics 2012;11(11):2419-28.
2012: Adriana Mattos; Leonie Beljaars; Marianne de Haan; Alie de Jager-Krikken; Klaas Poelstra
PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl₄-induced fibrogenesis in mice.
Journal of controlled release : official journal of the Controlled Release Society 2012;162(1):84-91.
2012: Klaas Poelstra; Jai Prakash; Leonie Beljaars
Drug targeting to the diseased liver.
Journal of controlled release : official journal of the Controlled Release Society 2012;161(2):188-97.
2011: Ruchi Bansal; Leonie Beljaars; Jai Prakash; Marieke de Ruijter; Klaas Poelstra
Peptide-modified albumin carrier explored as a novel strategy for a cell-specific delivery of interferon gamma to treat liver fibrosis.
Molecular pharmaceutics 2011;8(5):1899-909.
2011: Ruchi Bansal; Alie de Jager-Krikken; Klaas Poelstra; Eduard Post; Johannes H Proost; Jai Prakash
PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis.
Journal of controlled release : official journal of the Controlled Release Society 2011;154(3):233-40.
2011: Rosalina Wisastra; Rainer Bischoff; Hidde J Haisma; Harm Maarsingh; Klaas Poelstra; Frank J Dekker
Antibody-free detection of protein tyrosine nitration in tissue sections.
Chembiochem : a European journal of chemical biology 2011;12(13):2016-20.
2011: Klaas Poelstra; Detlef Schuppan
Targeted therapy of liver fibrosis/cirrhosis and its complications.
Journal of hepatology 2011;55(3):726-8.
2011: Ruchi Bansal; Leonie Beljaars; Eduard Post; Jai Prakash; Detlef Schuppan; Klaas Poelstra
Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice.
Hepatology (Baltimore, Md.) 2011;54(2):586-96.
2011: Marike Marjolijn van Beuge; Leonie Beljaars; Marie Lacombe; Eduard Post; Jai Prakash; Catharina Reker-Smit; Klaas Poelstra
Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632.
Pharmaceutical research 2011;28(8):2045-54.
2011: Kathryn T Chen; Madhu S Malo; Laura Kline Beasley-Topliffe; Klaas Poelstra; Jose Luis Millan; Golam Mostafa; Sayeda N Alam; Sundaram Ramasamy; H Shaw Warren; Elizabeth L Hohmann; Richard A Hodin
A role for intestinal alkaline phosphatase in the maintenance of local gut immunity.
Digestive diseases and sciences 2011;56(4):1020-7.
2011: Heni Rachmawati; Leonie Beljaars; Catharina Reker-Smit; Hester I Bakker; Anne-miek Van Loenen-Weemaes; Marjolijn N Lub-de Hooge; Klaas Poelstra
Intravenous administration of recombinant human IL-10 suppresses the development of anti-thy 1-induced glomerulosclerosis in rats.
PDA journal of pharmaceutical science and technology / PDA 2011;65(2):116-30.
2011: Edwin de Jong; Klaas Poelstra; Peter Winkel; Jai Prakash
Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC.
PloS one 2011;6(9):e25192.
2010: Jai Prakash; Edwin de Jong; Eduard Post; Ara K Mohammad; Leonie Beljaars; Klaas Poelstra
Targeting tumor stromal cells through a PDGF-beta receptor binding carrier.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e116.
2010: Jai Prakash; Edwin de Jong; Eduard Post; Annette S H Gouw; Leonie Beljaars; Klaas Poelstra
A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier.
Journal of controlled release : official journal of the Controlled Release Society 2010;145(2):91-101.
2010: Jai Prakash; Leonie Beljaars; Akshay K Harapanahalli; Mieke Zeinstra-Smith; Alie de Jager-Krikken; Martin Hessing; Herman Steen; Klaas Poelstra
Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor.
International journal of cancer. Journal international du cancer 2010;126(8):1966-81.
2010: Montserrat Moreno; Teresa Gonzalo; Robbert J Kok; Pau Sancho-Bru; Marike van Beuge; Josine Swart; Jai Prakash; Kai Temming; Constantino Fondevila; Leonie Beljaars; Marie Lacombe; Paul van der Hoeven; Vicente Arroyo; Klaas Poelstra; David A Brenner; Pere Ginès; Ramón Bataller
Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats.
Hepatology (Baltimore, Md.) 2010;51(3):942-52.
2009: Jai Prakash; Ruchi Bansal; Eduard Post; Alie de Jager-Krikken; Marjolijn N Lub-de Hooge; Klaas Poelstra
Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo.
Neoplasia (New York, N.Y.) 2009;11(12):1348-58.
2009: Winston W Bakker; Robert H Henning; Willem J Van Son; maria van pampus; Jan G Aarnoudse; Klary E Niezen-Koning; Theo Borghuis; Rianne M Jongman; Harry van Goor; Klaas Poelstra; gerjan navis; Marijke M Faas
Vascular contraction and preeclampsia: downregulation of the Angiotensin receptor 1 by hemopexin in vitro.
Hypertension 2009;53(6):959-64.
2009: A Tuin; Klaas Poelstra; A de Jager-Krikken; L Bok; W Raaben; M P Velders; G Dijkstra
Role of alkaline phosphatase in colitis in man and rats.
Gut 2009;58(3):379-87.
2008: Jai Prakash; Martin H de Borst; Marie Lacombe; Frank Opdam; Pieter A Klok; Harry van Goor; Dirk K F Meijer; Frits Moolenaar; Klaas Poelstra; Robbert J Kok
Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury.
Journal of the American Society of Nephrology : JASN 2008;19(11):2086-97.
2008: Jai Prakash; Martin H de Borst; Anne-miek Van Loenen-Weemaes; Marie Lacombe; Frank Opdam; Harry van Goor; Dirk K F Meijer; Frits Moolenaar; Klaas Poelstra; Robbert J Kok
Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis.
Pharmaceutical research 2008;25(10):2427-39.
2008: Marieke H Schoemaker; Marianne G Rots; Leonie Beljaars; Arjen Y Ypma; Peter L M Jansen; Klaas Poelstra; Han Moshage; Hidde J Haisma
PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells.
Molecular pharmaceutics 2008;5(3):399-406.
2008: Werner I Hagens; Leonie Beljaars; D A Mann; Matthew C Wright; Boris Julien; Sophie Lotersztajn; Catharina Reker-Smit; Klaas Poelstra
Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers.
The Journal of pharmacology and experimental therapeutics 2008;324(3):902-10.
2008: Marc Tarrus; Almer van der Sloot; Kai Temming; Marie Lacombe; Frank Opdam; Wim J Quax; Grietje Molema; Klaas Poelstra; Robbert J Kok
RGD-avidin-biotin pretargeting to alpha v beta 3 integrin enhances the proapoptotic activity of TNF alpha related apoptosis inducing ligand (TRAIL).
Apoptosis : an international journal on programmed cell death 2008;13(2):225-35.
2007: Kai Temming; Damon L Meyer; Roger F Zabinski; Peter D Senter; Klaas Poelstra; Grietje Molema; Robbert J Kok
Improved efficacy of alphavbeta3-targeted albumin conjugates by conjugation of a novel auristatin derivative.
Molecular pharmaceutics 2007;4(5):686-94.
2007: Valérie Serriere-Lanneau; Fatima Teixeira-Clerc; Liying Li; Marlies Schippers; Willie de Wries; Boris Julien; Jeanne Tran Van Nhieu; Sylvie Manin; Klaas Poelstra; Jerold Chun; Stéphane Carpentier; Thierry Levade; Ariane Mallat; Sophie Lotersztajn
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(9):2005-13.
2007: Joanna E Adrian; Jan A A M Kamps; Gerrit L Scherphof; Dirk K F Meijer; Anne-miek Van Loenen-Weemaes; Catharina Reker-Smit; Peter Terpstra; Klaas Poelstra
A novel lipid-based drug carrier targeted to the non-parenchymal cells, including hepatic stellate cells, in the fibrotic livers of bile duct ligated rats.
Biochimica et biophysica acta 2007;1768(6):1430-9.
2007: Teresa Gonzalo; Leonie Beljaars; Marja van de Bovenkamp; Kai Temming; Anne-Miek van Loenen; Catharina Reker-Smit; Dirk K F Meijer; Marie Lacombe; Frank Opdam; György Kéri; László Õrfi; Klaas Poelstra; Robbert J Kok
Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells.
The Journal of pharmacology and experimental therapeutics 2007;321(3):856-65.
2007: Joanna E Adrian; Klaas Poelstra; Gerrit L Scherphof; Dirk K F Meijer; Anne-miek Van Loenen-Weemaes; Catharina Reker-Smit; Henriëtte W M Morselt; Peter Zwiers; Jan A A M Kamps
Effects of a new bioactive lipid-based drug carrier on cultured hepatic stellate cells and liver fibrosis in bile duct-ligated rats.
The Journal of pharmacology and experimental therapeutics 2007;321(2):536-43.
2007: Heni Rachmawati; Catharina Reker-Smit; Marjolijn N Lub-de Hooge; Anne-miek Van Loenen-Weemaes; Klaas Poelstra; Leonie Beljaars
Chemical modification of interleukin-10 with mannose 6-phosphate groups yields a liver-selective cytokine.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(5):814-21.
2007: Rick Greupink; Catharina Reker-Smit; Johannes H Proost; Anne-miek Van Loenen-Weemaes; Marjolijn de Hooge; Klaas Poelstra; Leonie Beljaars
Pharmacokinetics of a hepatic stellate cell-targeted doxorubicin construct in bile duct-ligated rats.
Biochemical pharmacology 2007;73(9):1455-62.
2007: Werner I Hagens; Adriana mattos; Rick Greupink; Alie de Jager-Krikken; Catharina Reker-Smit; Anne-miek Van Loenen-Weemaes; I Annette S H Gouw; Klaas Poelstra; Leonie Beljaars
Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated.
Pharmaceutical research 2007;24(3):566-74.
2007: Joanna E Adrian; Klaas Poelstra; Jan A A M Kamps
Addressing liver fibrosis with liposomes targeted to hepatic stellate cells.
Journal of liposome research 2007;17(3-4):205-18.
2007: Joanna E Adrian; Jan A A M Kamps; Klaas Poelstra; Gerrit L Scherphof; Dirk K F Meijer; Yasufumi Kaneda
Delivery of viral vectors to hepatic stellate cells in fibrotic livers using HVJ envelopes fused with targeted liposomes.
Journal of drug targeting 2007;15(1):75-82.
2006: Kai Temming; Marie Lacombe; Henk E Moorlag; S A Asgeirsdottir; László Õrfi; György Kéri; Klaas Poelstra; Grietje Molema; Robbert J Kok
Targeting of the VEGF-kinase inhibitor PTK787 to angiogenic vasculature using RGD-equipped albumin carrier molecules.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e57.
2006: Kai Temming; Damon L Meyer; Roger F Zabinski; Eli C F Dijkers; Klaas Poelstra; Grietje Molema; Robbert J Kok
Evaluation of RGD-targeted albumin carriers for specific delivery of auristatin E to tumor blood vessels.
Bioconjugate chemistry 2006;17(6):1385-94.
2006: Kai Temming; Marie Lacombe; Roel Q J Schaapveld; László Õrfi; György Kéri; Klaas Poelstra; Grietje Molema; Robbert J Kok
Rational design of RGD-albumin conjugates for targeted delivery of the VEGF-R kinase inhibitor PTK787 to angiogenic endothelium.
ChemMedChem 2006;1(11):1200-3.
2006: Jai Prakash; Maria Sandovici; Vinay Saluja; Marie Lacombe; Roel Q J Schaapveld; Martin H de Borst; Harry van Goor; Robert H Henning; Johannes H Proost; Frits Moolenaar; György Këri; Dirk K F Meijer; Klaas Poelstra; Robbert J Kok
Intracellular delivery of the p38 mitogen-activated protein kinase inhibitor SB202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular cells: a novel strategy to treat renal fibrosis.
The Journal of pharmacology and experimental therapeutics 2006;319(1):8-19.
2006: Kai Temming; Marie Lacombe; Paul van der Hoeven; Jai Prakash; Teresa Gonzalo; Eli C F Dijkers; László Őrfi; György Kéri; Klaas Poelstra; Grietje Molema; Robbert J Kok
Delivery of the p38 MAPkinase inhibitor SB202190 to angiogenic endothelial cells: development of novel RGD-equipped and PEGylated drug-albumin conjugates using platinum(II)-based drug linker technology.
Bioconjugate chemistry 2006;17(5):1246-55.
2006: Rick Greupink; Hester I Bakker; Harry van Goor; Martin H de Borst; Leonie Beljaars; Klaas Poelstra
Mannose-6-phosphate/insulin-Like growth factor-II receptors may represent a target for the selective delivery of mycophenolic acid to fibrogenic cells.
Pharmaceutical research 2006;23(8):1827-34.
2006: Rick Greupink; Hester I Bakker; Wilma Bouma; Catharina Reker-Smit; Dirk K F Meijer; Leonie Beljaars; Klaas Poelstra
The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo.
The Journal of pharmacology and experimental therapeutics 2006;317(2):514-21.
2006: Teresa Gonzalo; Eduard Talman; Anke van de Ven; Kai Temming; Rick Greupink; Leonie Beljaars; Catharina Reker-Smit; Dirk K F Meijer; Grietje Molema; Klaas Poelstra; Robbert J Kok
Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):193-203.
2006: Werner I Hagens; Peter Olinga; Dirk K F Meijer; Geny M M Groothuis; Leonie Beljaars; Klaas Poelstra
Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(2):232-9.
2006: Joanna E Adrian; Klaas Poelstra; Gerrit L Scherphof; Grietje Molema; Dirk K F Meijer; Catharina Reker-Smit; Henriëtte W M Morselt; Jan A A M Kamps
Interaction of targeted liposomes with primary cultured hepatic stellate cells: Involvement of multiple receptor systems.
Journal of hepatology 2006;44(3):560-7.
2006: Annemarie Tuin; Ali Huizinga-Van der Vlag; Anne-miek Van Loenen-Weemaes; Dirk K F Meijer; Klaas Poelstra
On the role and fate of LPS-dephosphorylating activity in the rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(2):G377-85.
2005: Jai Prakash; Vinay Saluja; Jan Visser; Frits Moolenaar; Dirk K F Meijer; Klaas Poelstra; Robbert J Kok
Bioanalysis and pharmacokinetics of the p38 MAPkinase inhibitor SB202190 in rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;826(1-2):220-5.
2005: Rick Greupink; Hester I Bakker; Catharina Reker-Smit; Anne-miek Van Loenen-Weemaes; Robbert J Kok; Dirk K F Meijer; Leonie Beljaars; Klaas Poelstra
Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell.
Journal of hepatology 2005;43(5):884-92.
2005: Jai Prakash; Anne-miek Van Loenen-Weemaes; Marijke Haas Jimoh Akanbi; Johannes H Proost; Dirk K F Meijer; Frits Moolenaar; Klaas Poelstra; Robbert J Kok
Renal-selective delivery and angiotensin-converting enzyme inhibition by subcutaneously administered captopril-lysozyme.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(5):683-8.
2005: Xuedong Yan; Folkert Kuipers; Louis M Havekes; Rick Havinga; Bert Dontje; Klaas Poelstra; Gerrit L Scherphof; Jan A A M Kamps
The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse.
Biochemical and biophysical research communications 2005;328(1):57-62.
2004: X Yan; Klaas Poelstra; Gerrit L Scherphof; Jan A A M Kamps
A role for scavenger receptor B-I in selective transfer of rhodamine-PE from liposomes to cells.
Biochemical and biophysical research communications 2004;325(3):908-14.
2004: X Yan; Henriëtte W M Morselt; Gerrit L Scherphof; Klaas Poelstra; Jan A A M Kamps
The role of beta2-glycoprotein I in liposome-hepatocyte interaction.
Biochimica et biophysica acta 2004;1667(2):208-14.
2004: Heni Rachmawati; Leonie Beljaars; Catharina Reker-Smit; Anne-miek Van Loenen-Weemaes; Werner I Hagens; Dirk K F Meijer; Klaas Poelstra
Pharmacokinetic and biodistribution profile of recombinant human interleukin-10 following intravenous administration in rats with extensive liver fibrosis.
Pharmaceutical research 2004;21(11):2072-8.
2004: Jola J Kapojos; Anke Van den Berg; Theo Borghuis; Bernhard Banas; Sippie Huitema; Klaas Poelstra; Winston W Bakker
Enhanced ecto-apyrase activity of stimulated endothelial or mesangial cells is downregulated by glucocorticoids in vitro.
European journal of pharmacology 2004;501(1-3):191-8.
2004: Willem Ronald Verweij; Hafida Bentala; Ali Huizinga-Van der Vlag; Anne Miek van Loenen-Weemaes; Kor Kooi; Dirk K F Meijer; Klaas Poelstra
Protection against an Escherichia coli-induced sepsis by alkaline phosphatase in mice.
Shock (Augusta, Ga.) 2004;22(2):174-9.
2004: Marieke H Schoemaker; Laura Conde de la Rosa; Manon Buist-Homan; Titia E Vrenken; Rick Havinga; Klaas Poelstra; Hidde J Haisma; Peter L M Jansen; Han Moshage
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways.
Hepatology (Baltimore, Md.) 2004;39(6):1563-73.
2004: Jola J Kapojos; Klaas Poelstra; Theo Borghuis; Bernhard Banas; Winston W Bakker
Regulation of plasma hemopexin activity by stimulated endothelial or mesangial cells.
Nephron. Physiology 2004;96(1):P1-10.
2003: Leonie Beljaars; Betty Weert; Albert Geerts; Dirk K F Meijer; Klaas Poelstra
The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue.
Biochemical pharmacology 2003;66(7):1307-17.
2003: Marieke H Schoemaker; Willemijn M Gommans; Laura Conde de la Rosa; Manon Homan; Pieter A Klok; Christian Trautwein; Harry van Goor; Klaas Poelstra; Hidde J Haisma; Peter L M Jansen; Han Moshage
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation.
Journal of hepatology 2003;39(2):153-61.
2003: Jola J Kapojos; Klaas Poelstra; Theo Borghuis; Anke Van den Berg; Hans J Baelde; Pieter A Klok; Winston W Bakker
Induction of glomerular alkaline phosphatase after challenge with lipopolysaccharide.
International journal of experimental pathology 2003;84(3):135-44.
2003: H J C Eriksson; Willem Ronald Verweij; Klaas Poelstra; W L J Hinrichs; Gerhardus J De Jong; Govert W Somsen; Henderik W Frijlink
Investigations into the stabilisation of drugs by sugar glasses: II. Delivery of an inulin-stabilised alkaline phosphatase in the intestinal lumen via the oral route.
International journal of pharmaceutics 2003;257(1-2):273-81.
2003: Jola J Kapojos; Anke Van den Berg; Harry van Goor; Maroeska W M te Loo; Klaas Poelstra; Theo Borghuis; Winston W Bakker
Production of hemopexin by TNF-alpha stimulated human mesangial cells.
Kidney international 2003;63(5):1681-6.
2003: Barbro Melgert; Betty Weert; Huub Schellekens; Dirk K F Meijer; Klaas Poelstra
The pharmacokinetic and biological activity profile of dexamethasone targeted to sinusoidal endothelial and Kupffer cells.
Journal of drug targeting 2003;11(1):1-10.
2002: Hafida Bentala; Willem Ronald Verweij; Ali Huizinga-Van der Vlag; Anne-miek Van Loenen-Weemaes; Dirk K F Meijer; Klaas Poelstra
Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide.
Shock (Augusta, Ga.) 2002;18(6):561-6.
2002: Marieke H Schoemaker; Jenny E Ros; Manon Homan; Christian Trautwein; Peter Liston; Klaas Poelstra; Harry van Goor; Peter L M Jansen; Han Moshage
Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis.
Journal of hepatology 2002;36(6):742-50.
2002: Leonie Beljaars; Dirk K F Meijer; Klaas Poelstra
Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis.
Frontiers in bioscience : a journal and virtual library 2002;7():e214-22.
2001: Leonie Beljaars; Peter Olinga; Grietje Molema; Pieter De Bleser; Albert Geerts; Geny M M Groothuis; Dirk K F Meijer; Klaas Poelstra
Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).
Liver 2001;21(5):320-8.
2001: Barbro Melgert; Peter Olinga; Jan-Metske van der Laan; Betty Weert; J Cho; Detlef Schuppan; Geny M M Groothuis; Dirk K F Meijer; Klaas Poelstra
Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats.
Hepatology (Baltimore, Md.) 2001;34(4 Pt 1):719-28.
2001: Peter Olinga; Marjolijn T Merema; Marina H de Jager; F Derks; Barbro Melgert; Han Moshage; Maarten J H Slooff; Dirk K F Meijer; Klaas Poelstra; Geny M M Groothuis
Rat liver slices as a tool to study LPS-induced inflammatory response in the liver.
Journal of hepatology 2001;35(2):187-94.
2001: Barbro Melgert; Peter Olinga; Betty Weert; Maarten J H Slooff; Dirk K F Meijer; Klaas Poelstra; Geny M M Groothuis
Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):361-7.
2001: Dirk K F Meijer; Leonie Beljaars; Grietje Molema; Klaas Poelstra
Disease-induced drug targeting using novel peptide-ligand albumins.
Journal of controlled release : official journal of the Controlled Release Society 2001;72(1-3):157-64.
2001: Barbro Melgert; Peter Olinga; Betty Weert; Maarten J H Slooff; Dirk K F Meijer; Klaas Poelstra; Geny M M Groothuis
Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(4 Pt 1):361-7.
2000: Leonie Beljaars; Grietje Molema; Detlef Schuppan; Albert Geerts; Pieter De Bleser; Betty Weert; Dirk K F Meijer; Klaas Poelstra
Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor.
The Journal of biological chemistry 2000;275(17):12743-51.
2000: Barbro Melgert; Peter Olinga; V K Jack; Grietje Molema; Dirk K F Meijer; Klaas Poelstra
Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activation of hepatic cells.
Journal of hepatology 2000;32(4):603-11.
1999: Pieter J Swart; T Hirano; Mirjam E Kuipers; Y Ito; Catharina Smit; M Hashida; M Nishikawa; Leonie Beljaars; Dirk K F Meijer; Klaas Poelstra
Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers.
Journal of hepatology 1999;31(6):1034-43.
1999: Leonie Beljaars; Grietje Molema; Betty Weert; H Bonnema; Peter Olinga; Geny M M Groothuis; Dirk K F Meijer; Klaas Poelstra
Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells.
Hepatology (Baltimore, Md.) 1999;29(5):1486-93.
1998: Leonie Beljaars; Klaas Poelstra; Grietje Molema; Dirk K F Meijer
Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation.
Journal of hepatology 1998;29(4):579-88.
1998: C Albrecht; Barbro Melgert; Jürg Reichen; Klaas Poelstra; Dirk K F Meijer
Effect of chronic bile duct obstruction and LPS upon targeting of naproxen to the liver using naproxen-albumin conjugate.
Journal of drug targeting 1998;6(2):105-17.
1998: Barbro Melgert; E Wartna; C Lebbe; C Albrecht; Grietje Molema; Klaas Poelstra; Jürg Reichen; Dirk K F Meijer
Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver.
Journal of drug targeting 1998;5(5):329-42.
1997: C Albrecht; Dirk K F Meijer; C Lebbe; Hans Sägesser; Barbro Melgert; Klaas Poelstra; Jürg Reichen
Targeting naproxen coupled to human serum albumin to nonparenchymal cells reduces endotoxin-induced mortality in rats with biliary cirrhosis.
Hepatology (Baltimore, Md.) 1997;26(6):1553-9.
1997: Klaas Poelstra; Winston W Bakker; Pieter A Klok; Jan A A M Kamps; M J Hardonk; D K Meijer
Dephosphorylation of endotoxin by alkaline phosphatase in vivo.
The American journal of pathology 1997;151(4):1163-9.
1997: Klaas Poelstra; Winston W Bakker; Pieter A Klok; M J Hardonk; D K Meijer
A physiologic function for alkaline phosphatase: endotoxin detoxification.
Laboratory investigation; a journal of technical methods and pathology 1997;76(3):319-27.
1997: C Lebbe; Jürg Reichen; E Wartna; Hans Sägesser; Klaas Poelstra; Dirk K F Meijer
Targeting naproxen to non-parenchymal liver cells protects against endotoxin induced liver damage.
Journal of drug targeting 1997;4(5):303-10.
1993: Julius F W Baller; Klaas Poelstra; M J Hardonk; Winston W Bakker
A modified cerium-based histochemical method for detection of experimentally-induced ATPase impairment in glomeruli of the rat kidney.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(7):1105-9.
1993: Klaas Poelstra; Elisabeth Brouwer; Julius F W Baller; M J Hardonk; Winston W Bakker
Attenuation of anti-Thy1 glomerulonephritis in the rat by anti-inflammatory platelet-inhibiting agents.
The American journal of pathology 1993;142(2):441-50.
1993: Winston W Bakker; Klaas Poelstra; M J Hardonk
Relevance of adenine nucleotidases in the glomerular filtration barrier.
Nephron 1993;64(3):338-42.
1992: Winston W Bakker; Wia Timmerman; Klaas Poelstra; Gerard A Schuiling
Endotoxin induced intraplacental thrombotic tendency and decreased vascular ADPase in the pregnant rat.
Placenta 1992;13(3):281-90.
1992: Klaas Poelstra; E R Heynen; Julius F W Baller; M J Hardonk; Winston W Bakker
Modulation of anti-Thy1 nephritis in the rat by adenine nucleotides. Evidence for an anti-inflammatory role for nucleotidases.
Laboratory investigation; a journal of technical methods and pathology 1992;66(5):555-63.
1991: Klaas Poelstra; Julius F W Baller; M J Hardonk; Winston W Bakker
Demonstration of antithrombotic activity of glomerular adenosine diphosphatase.
Blood 1991;78(1):141-8.
1991: Klaas Poelstra; Julius F W Baller; M J Hardonk; Winston W Bakker
Intraglomerular thrombotic tendency and glomerular ADPase. Unilateral impairment of ADPase elicits a proaggregatory microenvironment in experimental glomerulonephritis.
Laboratory investigation; a journal of technical methods and pathology 1991;64(4):520-6.
1991: H W Frijlink; A C Eissens; N R Hefting; Klaas Poelstra; CF Lerk; Dirk K F Meijer
The effect of parenterally administered cyclodextrins on cholesterol levels in the rat.
Pharmaceutical research 1991;8(1):9-16.
1991: C E Hulstaert; Dharamdajal Kalicharan; Klaas Poelstra; Winston W Bakker; M J Hardonk
Survey of the occurrence of adenosine polyphosphatase in extracellular matrix of rat tissues. A cytochemical investigation.
Histochemistry 1991;96(5):441-7.
1990: Klaas Poelstra; M J Hardonk; J Koudstaal; Winston W Bakker
Intraglomerular platelet aggregation and experimental glomerulonephritis.
Kidney international 1990;37(6):1500-8.
1989: TR Koiter; Klaas Poelstra; M Scheringa; G C van der Schaaf-Verdonk; AB Steffens; Gerard A Schuiling
Glucose and insulin responses during mixed meals or infusion of glucose in pregnant and lactating rats.
Physiology & behavior 1989;46(5):881-7.
1989: Winston W Bakker; Klaas Poelstra; Wia Timmerman; M J Hardonk; TR Koiter; Gerard A Schuiling
Experimental endotoxemia in pregnancy: in situ glomerular microthrombus formation associated with impaired glomerular adenosine diphosphatase activity.
The Journal of laboratory and clinical medicine 1989;114(5):531-7.
1989: H van Goor; Klaas Poelstra; M J Hardonk
Cerium-based demonstration of phosphatase activity in plastic-embedded sections: a comparison with conventional methods.
Stain technology 1989;64(6):289-96.