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Igor Pogribny

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Igor P Pogribny; Frederick A Beland
Role of microRNAs in the regulation of drug metabolism and disposition genes in diabetes and liver disease.
Igor P Pogribny; Svitlana Shpyleva; Gordon Surratt; Volodymyr Tryndyak; Gonçalo Gamboa da Costa; Marta Pogribna; Frederick A Beland
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.
Igor Koturbash; Stepan Melnyk; Frederick A Beland; S Jill James; Igor P Pogribny
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.

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All Publications

2013: Igor P Pogribny; Frederick A Beland
Role of microRNAs in the regulation of drug metabolism and disposition genes in diabetes and liver disease.
Expert opinion on drug metabolism & toxicology 2013;9(6):713-24.
2013: Igor P Pogribny; Svitlana Shpyleva; Gordon Surratt; Volodymyr Tryndyak; Gonçalo Gamboa da Costa; Marta Pogribna; Frederick A Beland
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.
International journal of oncology 2013;42(5):1822-32.
2013: Igor Koturbash; Stepan Melnyk; Frederick A Beland; S Jill James; Igor P Pogribny
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Molecular carcinogenesis 2013;52(4):318-27.
2013: Takeki Uehara; Jyoji Yamate; Svitlana Shymonyak; Garrett R Ainslie; Ramon Bataller; Gary A Boorman; Blair U Bradford; Takeshi Izawa; Oksana Kosyk; Kristi Kutanzi; Levan Muskhelishvili; Igor P Pogribny; Ivan Rusyn
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
Toxicological sciences : an official journal of the Society of Toxicology 2013;132(1):53-63.
2013: Takeki Uehara; Katherine Tech; Volodymyr Tryndyak; Gary A Boorman; Blair U Bradford; Saurabh Chatterjee; Emmanuelle Jeannot; Oksana Kosyk; Jeffrey Macdonald; Ronald P Mason; Stepan Melnyk; Igor P Pogribny; Ivan Rusyn
Acetaminophen-induced acute liver injury in HCV transgenic mice.
Toxicology and applied pharmacology 2013;266(2):224-32.
2013: Igor P Pogribny; Ivan Rusyn
Environmental toxicants, epigenetics, and cancer.
Advances in experimental medicine and biology 2013;754():215-32.
2012: Natalie E Simpson; Volodymyr Tryndyak; Frederick A Beland; Marta Pogribna; Igor P Pogribny
Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype.
Epigenetics : official journal of the DNA Methylation Society 2012;7(12):1413-20.
2012: Volodymyr Tryndyak; Sharon A Ross; Ivan Rusyn; Svitlana Shymonyak; Frederick A Beland; Leonard Collins; Aline de Conti; James C Fuscoe; Tao Han; Tetyana Kobets; Igor Koturbash; Kristy Kutanzi; John R Latendresse; Stepan Melnyk; Igor P Pogribny
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(11):4592-602.
2012: Kaarthik John; Gail McMullen; Ofelia A Olivero; Igor P Pogribny; Frederick A Beland; Mona I Churchwell; M Margaret Pratt; Miriam C Poirier
Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.
Carcinogenesis 2012;33(11):2236-41.
2012: Linda S Von Tungeln; William M Witt; Daniel R Doerge; Gonçalo Gamboa da Costa; Igor Koturbash; M Matilde Marques; Igor P Pogribny; Frederick A Beland
Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.
International journal of cancer. Journal international du cancer 2012;131(9):2008-15.
2012: Igor Koturbash; Frederick A Beland; Natalie E Simpson; Igor P Pogribny
Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention.
Antioxidants & redox signaling 2012;17(2):365-74.
2012: Volodymyr Tryndyak; Sharon A Ross; Ivan Rusyn; Frederick A Beland; John R Latendresse; Beverly Montgomery; Igor P Pogribny
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.
Toxicology and applied pharmacology 2012;262(1):52-9.
2012: Masato Tsuchiya; Svitlana Shymonyak; Volodymyr Tryndyak; Cheng Ji; Neil Kaplowitz; Hiroshi Kono; Oksana Kosyk; Stepan Melnyk; Levan Muskhelishvili; Igor P Pogribny; Ivan Rusyn
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice.
Hepatology (Baltimore, Md.) 2012;56(1):130-9.
2012: Natalie E Simpson; Volodymyr P Tryndyak; Frederick A Beland; Igor P Pogribny
An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression.
Breast cancer research and treatment 2012;133(3):959-68.
2012: Igor Koturbash; Frederick A Beland; Igor P Pogribny
Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants.
Expert opinion on drug metabolism & toxicology 2012;8(5):597-606.
2012: Emmanuelle Jeannot; Oksana Kosyk; Stepan B Melnyk; Igor P Pogribny; Svitlana Shymoniak; Volodymyr Tryndyak; Batbayar Tumurbaatar; Steven A Weinman; Gary A Boorman; Blair U Bradford; Ivan Rusyn
Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice.
International journal of cancer. Journal international du cancer 2012;130(6):1347-56.
2011: Arun R Pandiri; Shyamal Peddada; Igor P Pogribny; Robert C Sills; Thai-Vu T Ton; Nigel J Walker; Gordon P Flake; Mark J Hoenerhoff; Hue-Hua L Hong; David E Malarkey; Greg R Olson; Mary D Boudreau
Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors.
Toxicologic pathology 2011;39(7):1065-74.
2011: Svitlana I Shpyleva; Erik J Tokar; Volodymyr Tryndyak; Michael P Waalkes; Frederick A Beland; Igor Koturbash; Levan Muskhelishvili; Igor P Pogribny
Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(2):433-40.
2011: Igor Koturbash; Fernando Pardo-Manuel Devillena; Frederick A Beland; Wanda Bodnar; Ivan Rusyn; Anne Scherhag; Kenneth Sexton; Jessica Sorrentino; James A Swenberg; Igor P Pogribny
Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):448-56.
2011: Igor Koturbash; Franz Zemp; Igor P Pogribny; Olga Kovalchuk
Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis.
Mutation research 2011;722(2):94-105.
2011: Igor P Pogribny; Levan Muskhelishvili; Volodymyr Tryndyak; Frederick A Beland
The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene.
Mutation research 2011;722(2):106-13.
2011: Igor Koturbash; Frederick A Beland; Igor P Pogribny
Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment.
Toxicology mechanisms and methods 2011;21(4):289-97.
2011: Igor Koturbash; Anne Scherhag; Jessica Sorrentino; Kenneth Sexton; Wanda Bodnar; Volodymyr Tryndyak; John R Latendresse; James A Swenberg; Frederick A Beland; Igor P Pogribny; Ivan Rusyn
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene.
Environmental health perspectives 2011;119(5):635-40.
2011: Blair U Bradford; Eric F Lock; Oksana Kosyk; Sungkyoon Kim; Takeki Uehara; David Harbourt; Michelle DeSimone; David Threadgill; Volodymyr Tryndyak; Igor P Pogribny; Lisa Bleyle; Dennis R Koop; Ivan Rusyn
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.
Toxicological sciences : an official journal of the Society of Toxicology 2011;120(1):206-17.
2011: Volodymyr Tryndyak; Tao Han; Levan Muskhelishvili; James C Fuscoe; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
Molecular nutrition & food research 2011;55(3):411-8.
2011: Emmanuelle Jeannot; Igor P Pogribny; Frederick A Beland; Ivan Rusyn
Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells.
Cancer letters 2011;301(2):161-7.
2011: Svitlana I Shpyleva; Volodymyr P Tryndyak; Olga Kovalchuk; Athena Starlard-Davenport; Vasy' F Chekhun; Frederick A Beland; Igor P Pogribny
Role of ferritin alterations in human breast cancer cells.
Breast cancer research and treatment 2011;126(1):63-71.
2010: Kristy R Kutanzi; Igor Koturbash; Roderick T Bronson; Igor P Pogribny; Olga Kovalchuk
Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats.
Mutation research 2010;694(1-2):1-6.
2010: Igor P Pogribny; Jody N Filkowski; Volodymyr P Tryndyak; Andrey Golubov; Svitlana I Shpyleva; Olga Kovalchuk
Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin.
International journal of cancer. Journal international du cancer 2010;127(8):1785-94.
2010: Eric J Formeister; Masato Tsuchiya; Hideki Fujii; Svitlana Shpyleva; Igor P Pogribny; Ivan Rusyn
Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma.
Mutation research 2010;692(1-2):26-33.
2010: Igor P Pogribny; Athena Starlard-Davenport; Volodymyr Tryndyak; Tao Han; Sharon A Ross; Ivan Rusyn; Frederick A Beland
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice.
Laboratory investigation; a journal of technical methods and pathology 2010;90(10):1437-46.
2010: A Starlard-Davenport; B Lyn-Cook; Frederick A Beland; Igor P Pogribny
The role of UDP-glucuronosyltransferases and drug transporters in breast cancer drug resistance.
Experimental oncology 2010;32(3):172-80.
2010: Igor P Pogribny
Epigenetic events in tumorigenesis: putting the pieces together.
Experimental oncology 2010;32(3):132-6.
2010: Jody N Filkowski; Yaroslav Ilnytskyy; Jan Tamminga; Igor Koturbash; Andrey Golubov; Tetyana Bagnyukova; Igor P Pogribny; Olga Kovalchuk
Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression.
Carcinogenesis 2010;31(6):1110-5.
2010: Volodymyr P Tryndyak; Frederick A Beland; Igor P Pogribny
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells.
International journal of cancer. Journal international du cancer 2010;126(11):2575-83.
2010: Christine L Powell; Blair U Bradford; Christopher Patrick Craig; Masato Tsuchiya; Takeki Uehara; Thomas M O'Connell; Igor P Pogribny; Stepan Melnyk; Dennis R Koop; Lisa Bleyle; David Threadgill; Ivan Rusyn
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(1):131-9.
2010: Athena Starlard-Davenport; Volodymyr Tryndyak; Smitha R James; Adam R Karpf; John R Latendresse; Frederick A Beland; Igor P Pogribny
Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.
Carcinogenesis 2010;31(3):376-81.
2010: Athena Starlard-Davenport; Volodymyr Tryndyak; Oksana Kosyk; Sharon R Ross; Ivan Rusyn; Frederick A Beland; Igor P Pogribny
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
Journal of nutrigenetics and nutrigenomics 2010;3(4-6):259-66.
2010: Igor P Pogribny
Ferroportin and hepcidin: a new hope in diagnosis, prognosis, and therapy for breast cancer.
Breast cancer research : BCR 2010;12(5):314.
2010: Athena Starlard-Davenport; Volodymyr Tryndyak; Oksana Kosyk; Sharon R Ross; Ivan Rusyn; Frederick A Beland; Igor P Pogribny
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
World review of nutrition and dietetics 2010;101():123-30.
2009: Igor P Pogribny
MicroRNA dysregulation during chemical carcinogenesis.
Epigenomics 2009;1(2):281-90.
2009: Igor P Pogribny; Svitlana I Shpyleva; Levan Muskhelishvili; Tetyana V Bagnyukova; S Jill James; Frederick A Beland
Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet.
Mutation research 2009;669(1-2):56-62.
2009: Igor P Pogribny
Genomic instability induced by heat-inactivated bacteria: implication to tumorigenesis.
Cell cycle (Georgetown, Tex.) 2009;8(13):1983.
2009: Igor P Pogribny; Volodymyr Tryndyak; Tetyana V Bagnyukova; Stepan Melnyk; Beverly Montgomery; Sharon A Ross; John R Latendresse; Ivan Rusyn; Frederick A Beland
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.
Journal of hepatology 2009;51(1):176-86.
2009: Igor P Pogribny; Frederick A Beland
DNA hypomethylation in the origin and pathogenesis of human diseases.
Cellular and molecular life sciences : CMLS 2009;66(14):2249-61.
2009: Volodymyr Tryndyak; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet.
Molecular carcinogenesis 2009;48(6):479-87.
2009: Igor P Pogribny; Levan Muskhelishvili; Volodymyr Tryndyak; Frederick A Beland
The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.
Toxicology and applied pharmacology 2009;235(3):305-11.
2008: Tetyana V Bagnyukova; Christine L Powell; Oleksandra Pavliv; Volodymyr Tryndyak; Igor P Pogribny
Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet.
Brain research 2008;1237():44-51.
2008: Igor P Pogribny; Adam R Karpf; Smitha R James; Stepan Melnyk; Tao Han; Volodymyr Tryndyak
Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet.
Brain research 2008;1237():25-34.
2008: Xiaoying Wang; Volodymyr Tryndyak; Eugene O Apostolov; Xiaoyan Yin; Sudhir V Shah; Igor P Pogribny; Alexei G Basnakian
Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation.
Cancer letters 2008;270(1):132-43.
2008: Tetyana V Bagnyukova; Volodymyr Tryndyak; Levan Muskhelishvili; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats.
Cell cycle (Georgetown, Tex.) 2008;7(20):3202-10.
2008: Igor P Pogribny; Volodymyr Tryndyak; Anna Boureiko; Stepan Melnyk; Tetyana V Bagnyukova; Beverly Montgomery; Ivan Rusyn
Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.
Mutation research 2008;644(1-2):17-23.
2008: Igor P Pogribny; Volodymyr Tryndyak; Sharon A Ross; Frederick A Beland
Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats.
Nutrition reviews 2008;66 Suppl 1():S33-5.
2008: Olga Kovalchuk; Jody Filkowski; James Meservy; Yaroslav Ilnytskyy; Volodymyr Tryndyak; Vasyl' F Chekhun; Igor P Pogribny
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.
Molecular cancer therapeutics 2008;7(7):2152-9.
2008: Jan Tamminga; Igor Koturbash; Mike Baker; Kristy Kutanzi; Palak Kathiria; Igor P Pogribny; Robert J Sutherland; Olga Kovalchuk
Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring.
Cell cycle (Georgetown, Tex.) 2008;7(9):1238-45.
2008: Tetyana V Bagnyukova; Volodymyr Tryndyak; Beverly Montgomery; Mona I Churchwell; Adam R Karpf; Smitha R James; Levan Muskhelishvili; Frederick A Beland; Igor P Pogribny
Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.
Carcinogenesis 2008;29(3):638-46.
2008: Igor Koturbash; Jonathan Loree; Kristy Kutanzi; Clayton Koganow; Igor P Pogribny; Olga Kovalchuk
In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen.
International journal of radiation oncology, biology, physics 2008;70(2):554-62.
2008: Carole yauk; Aris Polyzos; Andrea Rowan-Carroll; Christopher M Somers; Roger Godschalk; Frederik J Van Schooten; M Lynn Berndt; Igor P Pogribny; Igor Koturbash; Andrew Williams; George R Douglas; Olga Kovalchuk
Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):605-10.
2008: Igor P Pogribny; Ivan Rusyn; Frederick A Beland
Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents.
Environmental and molecular mutagenesis 2008;49(1):9-15.
2007: V M Kovalenko; Tetyana V Bagnyukova; O V Sergienko; LB Bondarenko; G M Shayakhmetova; A V Matvienko; Igor P Pogribny
Epigenetic changes in the rat livers induced by pyrazinamide treatment.
Toxicology and applied pharmacology 2007;225(3):293-9.
2007: T V Pryzimirska; Igor P Pogribny; Vasyl F Chekhun
The impact of tumor growth on plasma homocysteine levels and tissue-specific DNA methylation in Walker-256 tumor-bearing rats.
Experimental oncology 2007;29(4):262-6.
2007: Igor P Pogribny; Volodymyr Tryndyak; courtney woods; Sarah E Witt; Ivan Rusyn
Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.
Mutation research 2007;625(1-2):62-71.
2007: Igor P Pogribny; Tetyana V Bagnyukova; Volodymyr Tryndyak; Levan Muskhelishvili; Rocio Rodriguez-Juarez; Olga Kovalchuk; Tao Han; James C Fuscoe; Sharon A Ross; Frederick A Beland
Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis.
Toxicology and applied pharmacology 2007;225(1):61-9.
2007: Tetyana V Bagnyukova; Lidiya I Luzhna; Igor P Pogribny; Volodymyr Lushchak
Oxidative stress and antioxidant defenses in goldfish liver in response to short-term exposure to arsenite.
Environmental and molecular mutagenesis 2007;48(8):658-65.
2007: Olga Kovalchuk; Volodymyr Tryndyak; Beverly Montgomery; Alexander Boyko; Kristy Kutanzi; Franz Zemp; Alan Warbritton; John R Latendresse; Igor Kovalchuk; Frederick A Beland; Igor P Pogribny
Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression.
Cell cycle (Georgetown, Tex.) 2007;6(16):2010-8.
2007: Igor Koturbash; Alexander Boyko; Rocio Rodriguez-Juarez; Robert J McDonald; Volodymyr Tryndyak; Igor Kovalchuk; Igor P Pogribny; Olga Kovalchuk
Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.
Carcinogenesis 2007;28(8):1831-8.
2007: Igor P Pogribny; Volodymyr Tryndyak; Alexander Boyko; Rocio Rodriguez-Juarez; Frederick A Beland; Olga Kovalchuk
Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure.
Mutation research 2007;619(1-2):30-7.
2007: Vasyl F Chekhun; Nataliya Yu Lukyanova; Olga Kovalchuk; Volodymyr Tryndyak; Igor P Pogribny
Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets.
Molecular cancer therapeutics 2007;6(3):1089-98.
2007: Volodymyr Tryndyak; Olga Kovalchuk; Levan Muskhelishvili; Beverly Montgomery; Rocio Rodriguez-Juarez; Stepan Melnyk; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis.
Molecular carcinogenesis 2007;46(3):187-97.
2007: Juan Axume; Steven S Smith; Igor P Pogribny; David J Moriarty; Marie A Caudill
Global leukocyte DNA methylation is similar in African American and Caucasian women under conditions of controlled folate intake.
Epigenetics : official journal of the DNA Methylation Society 2007;2(1):66-8.
2007: Alexander Boyko; Palak Kathiria; Franz Zemp; Youli YAO; Igor P Pogribny; Igor Kovalchuk
Transgenerational changes in the genome stability and methylation in pathogen-infected plants: (virus-induced plant genome instability).
Nucleic acids research 2007;35(5):1714-25.
2007: Igor P Pogribny; Volodymyr Tryndyak; Levan Muskhelishvili; Ivan Rusyn; Sharon A Ross
Methyl deficiency, alterations in global histone modifications, and carcinogenesis.
The Journal of nutrition 2007;137(1 Suppl):216S-222S.
2006: Tetyana V Bagnyukova; Igor P Pogribny; Vasyl F Chekhun
MicroRNAs in normal and cancer cells: a new class of gene expression regulators.
Experimental oncology 2006;28(4):263-9.
2006: Jonathan Loree; Igor Koturbash; Kristy Kutanzi; Mike Baker; Igor P Pogribny; Olga Kovalchuk
Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis.
International journal of radiation biology 2006;82(11):805-15.
2006: Huban Kutay; Shoumei Bai; Jharna Datta; Tasneem Motiwala; Igor P Pogribny; Wendy Frankel; Samson T Jacob; Kalpana Ghoshal
Downregulation of miR-122 in the rodent and human hepatocellular carcinomas.
Journal of cellular biochemistry 2006;99(3):671-8.
2006: Igor Koturbash; Mike Baker; Jonathan Loree; Kristy Kutanzi; Darryl Hudson; Igor P Pogribny; Olga A Sedelnikova; William M Bonner; Olga Kovalchuk
Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo.
International journal of radiation oncology, biology, physics 2006;66(2):327-30.
2006: Volodymyr Tryndyak; Olga Kovalchuk; Igor P Pogribny
Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells.
Analytical biochemistry 2006;356(2):202-7.
2006: N R M Buist; Byron Glenn; Oliver Vugrek; Conrad Wagner; Sally P Stabler; Robert H Allen; Igor P Pogribny; Andreas Schulze; Steven H Zeisel; I Barić; S Harvey Mudd
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.
Journal of inherited metabolic disease 2006;29(4):538-45.
2006: Volodymyr Tryndyak; Levan Muskhelishvili; Olga Kovalchuk; Rocio Rodriguez-Juarez; Beverly Montgomery; Mona I Churchwell; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.
Carcinogenesis 2006;27(8):1713-20.
2006: Igor Koturbash; Rebecca E Rugo; Carrie A Hendricks; Jonathan Loree; B Thibault; Kristy Kutanzi; Igor P Pogribny; J C Yanch; Bevin P Engelward; Olga Kovalchuk
Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo.
Oncogene 2006;25(31):4267-75.
2006: Kalpana Ghoshal; Xin Li; Jharna Datta; Shoumei Bai; Igor P Pogribny; Marta Pogribny; Yan Huang; Donn Young; Samson T Jacob
A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.
The Journal of nutrition 2006;136(6):1522-7.
2006: Igor P Pogribny; Sharon A Ross; Volodymyr Tryndyak; Marta Pogribna; Lionel A Poirier; Tatiana V Karpinets
Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.
Carcinogenesis 2006;27(6):1180-6.
2006: Igor P Pogribny; Sharon A Ross; Carolyn Wise; Marta Pogribna; Elisabeth A Jones; Volodymyr Tryndyak; S Jill James; Yvonne P Dragan; Lionel A Poirier
Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency.
Mutation research 2006;593(1-2):80-7.
2006: Vasil F Chekhun; Galina I Kulik; Olga V Yurchenko; Volodymyr Tryndyak; Igor N Todor; Liliana S Luniv; Nadiya A Tregubova; Tamara V Pryzimirska; Beverly Montgomery; Nataliya V Rusetskaya; Igor P Pogribny
Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells.
Cancer letters 2006;231(1):87-93.
2006: Volodymyr Tryndyak; Olga Kovalchuk; Igor P Pogribny
Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.
Cancer biology & therapy 2006;5(1):65-70.
2005: Igor Koturbash; Igor P Pogribny; Olga Kovalchuk
Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis?
Biochemical and biophysical research communications 2005;337(2):526-33.
2005: Igor P Pogribny; Igor Koturbash; Volodymyr Tryndyak; Darryl Hudson; Sandie M L Stevenson; Olga A Sedelnikova; William M Bonner; Olga Kovalchuk
Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus.
Molecular cancer research : MCR 2005;3(10):553-61.
2005: Igor P Pogribny; T V Prizimirska; Galina I Kulik; M B Lutsiuk; O O Pentiuk; K P Postovitenko; M A Artemchuk; Lionel A Poirier; Vasyl F Chekhun
Age-related effects of methionine-enriched diet on plasma homocysteine concentration and methylation of hepatic DNA in rats.
Ukrainskiĭ biokhimicheskiĭ zhurnal 2005;77(4):114-9.
2005: I Barić; Mario Cuk; K Fumić; Oliver Vugrek; Robert H Allen; Byron Glenn; Miljenka Maradin; Leo Pazanin; Igor P Pogribny; Marko Rados; Vladimir Sarnavka; Andreas Schulze; Sally P Stabler; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
S-Adenosylhomocysteine hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during therapy.
Journal of inherited metabolic disease 2005;28(6):885-902.
2004: Joe Raiche; Rocio Rodriguez-Juarez; Igor P Pogribny; Olga Kovalchuk
Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice.
Biochemical and biophysical research communications 2004;325(1):39-47.
2004: Bernd Schwahn; Maurice D Laryea; Zhoutao Chen; Stepan Melnyk; Igor P Pogribny; Timothy A Garrow; S Jill James; Rima Rozen
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
The Biochemical journal 2004;382(Pt 3):831-40.
2004: Igor P Pogribny; Joe Raiche; Mark Slovack; Olga Kovalchuk
Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes.
Biochemical and biophysical research communications 2004;320(4):1253-61.
2004: Igor Kovalchuk; Vladimir Abramov; Igor P Pogribny; Olga Kovalchuk
Molecular aspects of plant adaptation to life in the Chernobyl zone.
Plant physiology 2004;135(1):357-63.
2004: Olga Kovalchuk; Paula Burke; Jill Besplug; Mark Slovack; Jody Filkowski; Igor P Pogribny
Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation.
Mutation research 2004;548(1-2):75-84.
2004: Igor P Pogribny; S Jill James; Stefanie Jernigan; Marta Pogribna
Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues.
Mutation research 2004;548(1-2):53-9.
2004: Ivo Baric; Ksenija Fumic; Byron Glenn; Mario Cuk; Andreas Schulze; James D Finkelstein; S Jill James; Vlatka Mejaski-Bosnjak; Leo Pazanin; Igor P Pogribny; Marko Rados; Vladimir Sarnavka; Mira Scukanec-Spoljar; Robert H Allen; Sally P Stabler; Lidija Uzelac; Oliver Vugrek; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4234-9.
2003: Farah Esfandiari; Ralph Green; Rebecca F Cotterman; Igor P Pogribny; S Jill James; Joshua Miller
Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver.
Carcinogenesis 2003;24(12):1935-40.
2003: S Jill James; Igor P Pogribny; Marta Pogribna; Barbara J Miller; Stefanie Jernigan; Stepan Melnyk
Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis.
The Journal of nutrition 2003;133(11 Suppl 1):3740S-3747S.
2003: Olga Kovalchuk; Paula Burke; Andrey Arkhipov; Nikolaj Kuchma; S Jill James; Igor Kovalchuk; Igor P Pogribny
Genome hypermethylation in Pinus silvestris of Chernobyl--a mechanism for radiation adaptation?
Mutation research 2003;529(1-2):13-20.
2003: Jacquetta M Trasler; Liyuan Deng; Stepan Melnyk; Igor P Pogribny; Francois Hiou-Tim; Sahar Sibani; Christopher C Oakes; En Li; S Jill James; Rima Rozen
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Carcinogenesis 2003;24(1):39-45.
2002: Igor P Pogribny; S Jill James
De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.
Cancer letters 2002;187(1-2):69-75.
2002: Richard Finnell; Ofer Spiegelstein; Bogdan Wlodarczyk; Aleata Triplett; Igor P Pogribny; Stepan Melnyk; Jill S James
DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation.
The Journal of nutrition 2002;132(8 Suppl):2457S-2461S.
2002: S Jill James; Stepan Melnyk; Marta Pogribna; Igor P Pogribny; Marie A Caudill
Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology.
The Journal of nutrition 2002;132(8 Suppl):2361S-2366S.
2002: Ping Yi; Igor P Pogribny; S Jill James
Multiplex PCR for simultaneous detection of 677 C-->T and 1298 A-->C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk.
Cancer letters 2002;181(2):209.
2002: Igor P Pogribny; S Jill James
Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation.
Cancer letters 2002;176(2):169-74.
2002: Sahar Sibani; Stepan Melnyk; Igor P Pogribny; Wei Wang; Francois Hiou-Tim; Liyuan Deng; Jacquetta M Trasler; S Jill James; Rima Rozen
Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice.
Carcinogenesis 2002;23(1):61-5.
2001: Marie A Caudill; J C Wang; Stepan Melnyk; Igor P Pogribny; Stefanie Jernigan; Michael D Collins; J Santos-Guzman; Marian E Swendseid; Edward A Cogger; S Jill James
Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice.
The Journal of nutrition 2001;131(11):2811-8.
2001: Lihadh Al-Gazali; Rengasamy Padmanabhan; Stepan Melnyk; Ping Yi; Igor P Pogribny; Marta Pogribna; Mahmood Bakir; Z A Hamid; Yousef M Abdulrazzaq; Adekunle Dawodu; S Jill James
Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect.
American journal of medical genetics 2001;103(2):128-32.
2001: Marta Pogribna; Stepan Melnyk; Igor P Pogribny; Abalo Chango; Ping Yi; S Jill James
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
American journal of human genetics 2001;69(1):88-95.
2001: Zhoutao Chen; Andrew C Karaplis; S L Ackerman; Igor P Pogribny; Stepan Melnyk; Suzanne Lussier-Cacan; Moy Fong Chen; Aditya Pai; S W John; R S Smith; Teodoro Bottiglieri; P Bagley; Jacob Selhub; M A Rudnicki; S Jill James; Rima Rozen
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
Human molecular genetics 2001;10(5):433-43.
2000: Ping Yi; Stepan Melnyk; Marta Pogribna; Igor P Pogribny; R Jean Hine; S Jill James
Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation.
The Journal of biological chemistry 2000;275(38):29318-23.
2000: Igor P Pogribny; Marta Pogribna; J K Christman; S Jill James
Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: possible in vivo relevance during tumorigenesis.
Cancer research 2000;60(3):588-94.
2000: Stepan Melnyk; Marta Pogribna; Igor P Pogribny; Ping Yi; S Jill James
Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrations.
Clinical chemistry 2000;46(2):265-72.
1999: Stepan Melnyk; Marta Pogribna; Barbara J Miller; AG Basnakian; Igor P Pogribny; S Jill James
Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells.
Cancer letters 1999;146(1):35-44.
1999: S Jill James; Marta Pogribna; Igor P Pogribny; Stepan Melnyk; R Jean Hine; J B Gibson; Ping Yi; D L Tafoya; D H Swenson; V L Wilson; David W Gaylor
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
The American journal of clinical nutrition 1999;70(4):495-501.
1999: Igor P Pogribny; Ping Yi; S Jill James
A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands.
Biochemical and biophysical research communications 1999;262(3):624-8.
1999: Stepan Melnyk; Marta Pogribna; Igor P Pogribny; R Jean Hine; S Jill James
A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.
The Journal of nutritional biochemistry 1999;10(8):490-7.
1998: Robert A Jacob; D M Gretz; P C Taylor; S Jill James; Igor P Pogribny; Barbara J Miller; Susanne M Henning; Marian E Swendseid
Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women.
The Journal of nutrition 1998;128(7):1204-12.
1997: Igor P Pogribny; Levan Muskhelishvili; Barbara J Miller; S Jill James
Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats.
Carcinogenesis 1997;18(11):2071-6.
1997: BA Smith; Mugimane G Manjanatha; Igor P Pogribny; Roberta A Mittelstaedt; Tao Chen; NF Fullerton; Frederick A Beland; Robert H Heflich
Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.
Mutation research 1997;379(1):61-8.
1997: Igor P Pogribny; Barbara J Miller; S Jill James
Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat.
Cancer letters 1997;115(1):31-8.
1997: S Jill James; Barbara J Miller; AG Basnakian; Igor P Pogribny; Marta Pogribna; Levan Muskhelishvili
Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats.
Carcinogenesis 1997;18(2):287-93.
1997: Y I Kim; Igor P Pogribny; AG Basnakian; Joshua Miller; Jacob Selhub; S Jill James; J B Mason
Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene.
The American journal of clinical nutrition 1997;65(1):46-52.
1996: Young-In Kim; Igor P Pogribny; R N Salomon; S W Choi; D E Smith; S Jill James; J B Mason
Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate.
The American journal of pathology 1996;149(4):1129-37.
1995: Igor P Pogribny; Lionel A Poirier; S Jill James
Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats.
Carcinogenesis 1995;16(11):2863-7.
1995: Igor P Pogribny; A G Basnakian; Barbara J Miller; N G Lopatina; Lionel A Poirier; S Jill James
Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.
Cancer research 1995;55(9):1894-901.