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Paul Polakis

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Molecular Sequence Data

Genes & Molecular Sequences

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Anatomy

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Signal Transduction

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Phosphorylation

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Co-Publications
Name
28
Rubinfeld, Bonnee
12
Albert, IN
6
Koeppen, Hartmut
4
Ross, Sarajane
4
Tice, David
3
Porfiri, E
3
Soloviev, Irina
3
Fong, Sharon
3
Frantz, Gretchen
3
Gao, Wei-Qiang
3
Hart, MJ
2
Crowley, Craig
2
Eberhard, David
2
Leow, Ching Ching
2
Moran, Michael

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Publications

TOP 3
Polakis Paul
Formation of the blood-brain barrier: Wnt signaling seals the deal.
Morrell Nathan T; Leucht Philipp; Zhao Ludan; Kim Jae-Beom; ten Berge Derk; Ponnusamy Karthik; Carre A Lyonel; Dudek Henryk; Zachlederova Marie; McElhaney Michael; Brunton Shirley; Gunzner Janet; Callow Marinella; Polakis Paul; Costa Mike; Zhang Xiaoyan M; Helms Jill A; Nusse Roel
Liposomal packaging generates Wnt protein with in vivo biological activity.
Wang Bu-Er; Wang Xi-De; Ernst James A; Polakis Paul; Gao Wei-Qiang
Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling.

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All Publications

2008: Polakis Paul
Formation of the blood-brain barrier: Wnt signaling seals the deal.
The Journal of cell biology 2008;183(3):371-3.
2008: Morrell Nathan T; Leucht Philipp; Zhao Ludan; Kim Jae-Beom; ten Berge Derk; Ponnusamy Karthik; Carre A Lyonel; Dudek Henryk; Zachlederova Marie; McElhaney Michael; Brunton Shirley; Gunzner Janet; Callow Marinella; Polakis Paul; Costa Mike; Zhang Xiaoyan M; Helms Jill A; Nusse Roel
Liposomal packaging generates Wnt protein with in vivo biological activity.
PloS one 2008;3(8):e2930.
2008: Wang Bu-Er; Wang Xi-De; Ernst James A; Polakis Paul; Gao Wei-Qiang
Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling.
PloS one 2008;3(5):e2186.
2007: DeAlmeida Venita I; Miao Li; Ernst James A; Koeppen Hartmut; Polakis Paul; Rubinfeld Bonnee
The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo.
Cancer research 2007;67(11):5371-9.
2007: Chen Youjun; Clark Suzanna; Wong Terence; Chen Yongmei; Chen Yvonne; Dennis Mark S; Luis Elizabeth; Zhong Fiona; Bheddah Sheila; Koeppen Hartmut; Gogineni Alvin; Ross Sarajane; Polakis Paul; Mallet William
Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models.
Cancer research 2007;67(10):4924-32.
2007: Polakis Paul
The many ways of Wnt in cancer.
Current opinion in genetics & development 2007;17(1):45-51.
2006: Shulewitz M; Soloviev I; Wu T; Koeppen H; Polakis P; Sakanaka C
Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer.
Oncogene 2006;25(31):4361-9.
2006: Rubinfeld Bonnee; Upadhyay Archana; Clark Suzanna L; Fong Sharon E; Smith Victoria; Koeppen Hartmut; Ross Sarajane; Polakis Paul
Identification and immunotherapeutic targeting of antigens induced by chemotherapy.
Nature biotechnology 2006;24(2):205-9.
2005: Leow Ching Ching; Polakis Paul; Gao Wei-Qiang
A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma.
Annals of the New York Academy of Sciences 2005;1059():174-83.
2005: Polakis Paul
Arming antibodies for cancer therapy.
Current opinion in pharmacology 2005;5(4):382-7.
2005: Jubb Adrian M; Zhong Fiona; Bheddah Sheila; Grabsch Heike I; Frantz Gretchen D; Mueller Wolfram; Kavi Vidya; Quirke Phil; Polakis Paul; Koeppen Hartmut
EphB2 is a prognostic factor in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(14):5181-7.
2004: Zhang Yan; Eberhard David A; Frantz Gretchen D; Dowd Patrick; Wu Thomas D; Zhou Yan; Watanabe Colin; Luoh Shiuh-Ming; Polakis Paul; Hillan Kenneth J; Wood William I; Zhang Zemin
GEPIS--quantitative gene expression profiling in normal and cancer tissues.
Bioinformatics (Oxford, England) 2004;20(15):2390-8.
2004: Leow Ching Ching; Romero Maria S; Ross Sarajane; Polakis Paul; Gao Wei-Qiang
Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells.
Cancer research 2004;64(17):6050-7.
2004: Mao Weiguang; Luis Elizabeth; Ross Sarajane; Silva Johnny; Tan Christine; Crowley Craig; Chui Clarissa; Franz Gretchen; Senter Peter; Koeppen Hartmut; Polakis Paul
EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer.
Cancer research 2004;64(3):781-8.
2004: Shibamoto Sayumi; Winer Jane; Williams Mickey; Polakis Paul
A blockade in Wnt signaling is activated following the differentiation of F9 teratocarcinoma cells.
Experimental cell research 2004;292(1):11-20.
2002: Polakis Paul
Casein kinase 1: a Wnt'er of disconnect.
Current biology : CB 2002;12(14):R499-R501.
2002: Tice David A; Szeto Wayne; Soloviev Irina; Rubinfeld Bonnee; Fong Sharon E; Dugger Debra L; Winer Jane; Williams P Mickey; Wieand David; Smith Victoria; Schwall Ralph H; Pennica Diane; Polakis Paul
Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling.
The Journal of biological chemistry 2002;277(16):14329-35.
2002: Tice David A; Soloviev Irina; Polakis Paul
Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes.
The Journal of biological chemistry 2002;277(8):6118-23.
2001: Rubinfeld B; Tice D A; Polakis P
Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.
The Journal of biological chemistry 2001;276(42):39037-45.
2001: Polakis P
More than one way to skin a catenin.
Cell 2001;105(5):563-6.
2001: Szeto W; Jiang W; Tice D A; Rubinfeld B; Hollingshead P G; Fong S E; Dugger D L; Pham T; Yansura D G; Wong T A; Grimaldi J C; Corpuz R T; Singh J S; Frantz G D; Devaux B; Crowley C W; Schwall R H; Eberhard D A; Rastelli L; Polakis P; Pennica D
Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid.
Cancer research 2001;61(10):4197-205.
2000: Polakis P
Wnt signaling and cancer.
Genes & development 2000;14(15):1837-51.
1999: Crawford H C; Fingleton B M; Rudolph-Owen L A; Goss K J; Rubinfeld B; Polakis P; Matrisian L M
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors.
Oncogene 1999;18(18):2883-91.
1999: Hart M; Concordet J P; Lassot I; Albert I; del los Santos R; Durand H; Perret C; Rubinfeld B; Margottin F; Benarous R; Polakis P
The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.
Current biology : CB 1999;9(4):207-10.
1999: Polakis P
The oncogenic activation of beta-catenin.
Current opinion in genetics & development 1999;9(1):15-21.
1999: Polakis P; Hart M; Rubinfeld B
Defects in the regulation of beta-catenin in colorectal cancer.
Advances in experimental medicine and biology 1999;470():23-32.
1998: Hart M J; de los Santos R; Albert I N; Rubinfeld B; Polakis P
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
Current biology : CB 1998;8(10):573-81.
1997: Porfiri E; Rubinfeld B; Albert I; Hovanes K; Waterman M; Polakis P
Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.
Oncogene 1997;15(23):2833-9.
1997: Rubinfeld B; Albert I; Porfiri E; Munemitsu S; Polakis P
Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.
Cancer research 1997;57(20):4624-30.
1997: Thomas J E; Smith M; Tonkinson J L; Rubinfeld B; Polakis P
Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(7):801-9.
1997: Rubinfeld B; Robbins P; El-Gamil M; Albert I; Porfiri E; Polakis P
Stabilization of beta-catenin by genetic defects in melanoma cell lines.
Science (New York, N.Y.) 1997;275(5307):1790-2.
1997: Vleminckx K; Wong E; Guger K; Rubinfeld B; Polakis P; Gumbiner B M
Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis.
The Journal of cell biology 1997;136(2):411-20.
1997: Hayashi S; Rubinfeld B; Souza B; Polakis P; Wieschaus E; Levine A J
A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):242-7.
1996: Thomas J E; Smith M; Rubinfeld B; Gutowski M; Beckmann R P; Polakis P
Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1.
The Journal of biological chemistry 1996;271(45):28630-5.
1996: Hart M J; Sharma S; elMasry N; Qiu R G; McCabe P; Polakis P; Bollag G
Identification of a novel guanine nucleotide exchange factor for the Rho GTPase.
The Journal of biological chemistry 1996;271(41):25452-8.
1996: Munemitsu S; Albert I; Rubinfeld B; Polakis P
Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein.
Molecular and cellular biology 1996;16(8):4088-94.
1996: Hart M J; Callow M G; Souza B; Polakis P
IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.
The EMBO journal 1996;15(12):2997-3005.
1996: Rubinfeld B; Albert I; Porfiri E; Fiol C; Munemitsu S; Polakis P
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.
Science (New York, N.Y.) 1996;272(5264):1023-6.
1996: Papkoff J; Rubinfeld B; Schryver B; Polakis P
Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes.
Molecular and cellular biology 1996;16(5):2128-34.
1995: Rubinfeld B; Souza B; Albert I; Munemitsu S; Polakis P
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.
The Journal of biological chemistry 1995;270(10):5549-55.
1995: Munemitsu S; Albert I; Souza B; Rubinfeld B; Polakis P
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):3046-50.
1995: Polakis P
Mutations in the APC gene and their implications for protein structure and function.
Current opinion in genetics & development 1995;5(1):66-71.
1995: Rubinfeld B; Polakis P
Purification of baculovirus-produced Rap1 GTPase-activating protein.
Methods in enzymology 1995;255():31-8.
1994: Munemitsu S; Souza B; Müller O; Albert I; Rubinfeld B; Polakis P
The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.
Cancer research 1994;54(14):3676-81.
1994: Sato K Y; Polakis P G; Haubruck H; Fasching C L; McCormick F; Stanbridge E J
Analysis of the tumor suppressor activity of the K-rev-1 gene in human tumor cell lines.
Cancer research 1994;54(2):552-9.
1994: Weiss J; Rubinfeld B; Polakis P G; McCormick F; Cavenee W K; Arden K C
The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35.
Cytogenetics and cell genetics 1994;66(1):18-21.
1993: Rubinfeld B; Souza B; Albert I; Müller O; Chamberlain S H; Masiarz F R; Munemitsu S; Polakis P
Association of the APC gene product with beta-catenin.
Science (New York, N.Y.) 1993;262(5140):1731-4.
1993: Polakis P; McCormick F
Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target.
The Journal of biological chemistry 1993;268(13):9157-60.
1992: Rubinfeld B; Crosier W J; Albert I; Conroy L; Clark R; McCormick F; Polakis P
Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis.
Molecular and cellular biology 1992;12(10):4634-42.
1992: McCabe P C; Haubruck H; Polakis P; McCormick F; Innis M A
Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae.
Molecular and cellular biology 1992;12(9):4084-92.
1992: Polakis P; Rubinfeld B; McCormick F
Phosphorylation of rap1GAP in vivo and by cAMP-dependent kinase and the cell cycle p34cdc2 kinase in vitro.
The Journal of biological chemistry 1992;267(15):10780-5.
1992: Wong G; Müller O; Clark R; Conroy L; Moran M F; Polakis P; McCormick F
Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62.
Cell 1992;69(3):551-8.
1992: Martin G A; Yatani A; Clark R; Conroy L; Polakis P; Brown A M; McCormick F
GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents.
Science (New York, N.Y.) 1992;255(5041):192-4.
1992: Polakis P; McCormick F
Interactions between p21ras proteins and their GTPase activating proteins.
Cancer surveys 1992;12():25-42.
1991: Rubinfeld B; Wong G; Bekesi E; Wood A; Heimer E; McCormick F; Polakis P
A synthetic peptide corresponding to a sequence in the GTPase activating protein inhibits p21ras stimulation and promotes guanine nucleotide exchange.
International journal of peptide and protein research 1991;38(1):47-53.
1991: Rubinfeld B; Munemitsu S; Clark R; Conroy L; Watt K; Crosier W J; McCormick F; Polakis P
Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1.
Cell 1991;65(6):1033-42.
1991: Moran M F; Polakis P; McCormick F; Pawson T; Ellis C
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.
Molecular and cellular biology 1991;11(4):1804-12.
1991: Polakis P G; Rubinfeld B; Evans T; McCormick F
Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):239-43.
1991: McCormick F; Martin G A; Clark R; Bollag G; Polakis P
Regulation of ras p21 by GTPase activating proteins.
Cold Spring Harbor symposia on quantitative biology 1991;56():237-41.
1990: Munemitsu S; Innis M A; Clark R; McCormick F; Ullrich A; Polakis P
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
Molecular and cellular biology 1990;10(11):5977-82.
1990: Hart M J; Polakis P G; Evans T; Cerione R A
The identification and characterization of an epidermal growth factor-stimulated phosphorylation of a specific low molecular weight GTP-binding protein in a reconstituted phospholipid vesicle system.
The Journal of biological chemistry 1990;265(11):5990-6001.

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