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Sudhir Agrawal

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Ekambar R Kandimalla; Nicola La Monica; Tim Sullivan; Daqing Wang; Dong Yu; Lakshmi Bhagat; Sudhir Agrawal
Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.
Tao Lan; Victoria J Philbin; Mallikarjuna R Putta; Tim Sullivan; Jimmy X Tang; Daqing Wang; Dong Yu; Lakshmi Bhagat; Ekambar R Kandimalla; Nicola La Monica; Sudhir Agrawal
Design of synthetic oligoribonucleotide-based agonists of Toll-like receptor 3 and their immune response profiles in vitro and in vivo.
Lakshmi Bhagat; Mallikarjuna R Putta; Daqing Wang; Dong Yu; Tao Lan; Weiwen Jiang; Zhenhua Sun; Hao Wang; Jimmy X Tang; Nicola La Monica; Ekambar R Kandimalla; Sudhir Agrawal
Novel oligonucleotides containing two 3'-ends complementary to target mRNA show optimal gene-silencing activity.

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All Publications

2013: Ekambar R Kandimalla; Nicola La Monica; Tim Sullivan; Daqing Wang; Dong Yu; Lakshmi Bhagat; Sudhir Agrawal
Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.
Nucleic acids research 2013;41(6):3947-61.
2013: Tao Lan; Victoria J Philbin; Mallikarjuna R Putta; Tim Sullivan; Jimmy X Tang; Daqing Wang; Dong Yu; Lakshmi Bhagat; Ekambar R Kandimalla; Nicola La Monica; Sudhir Agrawal
Design of synthetic oligoribonucleotide-based agonists of Toll-like receptor 3 and their immune response profiles in vitro and in vivo.
Organic & biomolecular chemistry 2013;11(6):1049-58.
2011: Lakshmi Bhagat; Mallikarjuna R Putta; Daqing Wang; Dong Yu; Tao Lan; Weiwen Jiang; Zhenhua Sun; Hao Wang; Jimmy X Tang; Nicola La Monica; Ekambar R Kandimalla; Sudhir Agrawal
Novel oligonucleotides containing two 3'-ends complementary to target mRNA show optimal gene-silencing activity.
Journal of medicinal chemistry 2011;54(8):3027-36.
2011: Ekambar R Kandimalla; Tao Lan; Melissa Precopio; Mary Struthers; Zhenhua Sun; Hao Wang; Thomas Wisniewski; Sudhir Agrawal; Andrew J Bett; Sheri A Dubey; Weiwen Jiang; Danilo R Casimiro
Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists.
Cellular immunology 2011;270(2):126-34.
2010: Mary Struthers; Andrew J Bett; Thomas Wisniewski; Sheri A Dubey; Melissa Precopio; Weiwen Jiang; Zhenhua Sun; Hao Wang; Ireneusz Nowak; Mallikarjuna R Putta; Dong Yu; Jimmy X Tang; Ekambar R Kandimalla; Sudhir Agrawal; Danilo R Casimiro
Synthesis and immunological activities of novel agonists of toll-like receptor 9.
Cellular immunology 2010;263(1):105-13.
2010: Mallikarjuna Reddy Putta; Fu-Gang Zhu; Daqing Wang; Lakshmi Bhagat; Meiru Dai; Ekambar R Kandimalla; Sudhir Agrawal
Peptide conjugation at the 5'-end of oligodeoxynucleotides abrogates toll-like receptor 9-mediated immune stimulatory activity.
Bioconjugate chemistry 2010;21(1):39-45.
2009: Tao Lan; Meiru Dai; Daqing Wang; Fu-Gang Zhu; Ekambar R Kandimalla; Sudhir Agrawal
Toll-like receptor 7 selective synthetic oligoribonucleotide agonists: synthesis and structure-activity relationship studies.
Journal of medicinal chemistry 2009;52(21):6871-9.
2009: Tao Lan; Mallikarjuna R Putta; Daqing Wang; Meiru Dai; Dong Yu; Ekambar R Kandimalla; Sudhir Agrawal
Synthetic oligoribonucleotides-containing secondary structures act as agonists of Toll-like receptors 7 and 8.
Biochemical and biophysical research communications 2009;386(3):443-8.
2009: Dong Yu; Daqing Wang; Fu-Gang Zhu; Lakshmi Bhagat; Meiru Dai; Ekambar R Kandimalla; Sudhir Agrawal
Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9.
Journal of medicinal chemistry 2009;52(16):5108-14.
2009: Tao Lan; Lakshmi Bhagat; Daqing Wang; Meiru Dai; Ekambar R Kandimalla; Sudhir Agrawal
Synthetic oligoribonucleotides containing arabinonucleotides act as agonists of TLR7 and 8.
Bioorganic & medicinal chemistry letters 2009;19(7):2044-7.
2009: Daqing Wang; Lakshmi Bhagat; Dong Yu; Fu-Gang Zhu; Jimmy X Tang; Ekambar R Kandimalla; Sudhir Agrawal
Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9.
Journal of medicinal chemistry 2009;52(2):551-8.
2008: Dong Yu; Mallikarjuna R Putta; Lakshmi Bhagat; Meiru Dai; Daqing Wang; Anthony F Trombino; Tim Sullivan; Ekambar R Kandimalla; Sudhir Agrawal
Impact of secondary structure of toll-like receptor 9 agonists on interferon alpha induction.
Antimicrobial agents and chemotherapy 2008;52(12):4320-5.
2007: Dong Yu; Mallikarjuna R Putta; Lakshmi Bhagat; Yukui Li; Fugang Zhu; Daqing Wang; Jimmy X Tang; Ekambar R Kandimalla; Sudhir Agrawal
Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs.
Journal of medicinal chemistry 2007;50(25):6411-8.
2007: Fu-Gang Zhu; Ekambar R Kandimalla; Dong Yu; Sudhir Agrawal
Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice.
The Journal of allergy and clinical immunology 2007;120(3):631-7.
2007: Tao Lan; Ekambar R Kandimalla; Dong Yu; Lakshmi Bhagat; Yukui Li; Daqing Wang; Fugang Zhu; Jimmy X Tang; Mallikarjuna R Putta; Yanping Cong; Anthony F Trombino; Tim Sullivan; Sudhir Agrawal
Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13750-5.
2006: Mallikarjuna R Putta; FuGang Zhu; Yukui Li; Lakshmi Bhagat; Yanping Cong; Ekambar R Kandimalla; Sudhir Agrawal
Novel oligodeoxynucleotide agonists of TLR9 containing N3-Me-dC or N1-Me-dG modifications.
Nucleic acids research 2006;34(11):3231-8.
2005: Yukui Li; Ekambar R Kandimalla; Dong Yu; Sudhir Agrawal
Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice.
International immunopharmacology 2005;5(6):981-91.
2005: Ekambar R Kandimalla; Lakshmi Bhagat; Yukui Li; Dong Yu; Daqing Wang; Yan-Ping Cong; Sam S Song; Jimmy X Tang; Tim Sullivan; Sudhir Agrawal
Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6925-30.
2005: Daqing Wang; Ekambar R Kandimalla; Dong Yu; Jimmy X Tang; Sudhir Agrawal
Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity.
Vaccine 2005;23(20):2614-22.
2004: Sudhir Agrawal; Ekambar R Kandimalla
Role of Toll-like receptors in antisense and siRNA [corrected].
Nature biotechnology 2004;22(12):1533-7.
2004: Fu-Gang Zhu; Ekambar R Kandimalla; Dong Yu; Jimmy X Tang; Sudhir Agrawal
Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice.
International immunopharmacology 2004;4(7):851-62.
2004: Ekambar R Kandimalla; Rajendra K Pandey; Sudhir Agrawal
Hybridization-based fluorescence assay allows quantitation of single-stranded oligodeoxynucleotides in low nanomolar range.
Analytical biochemistry 2004;328(1):93-5.
2004: Daqing Wang; Yukui Li; Dong Yu; Sam S Song; Ekambar R Kandimalla; Sudhir Agrawal
Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs.
International journal of oncology 2004;24(4):901-8.
2003: Ekambar R Kandimalla; Lakshmi Bhagat; Fu-Gang Zhu; Dong Yu; Yan-Ping Cong; Daqing Wang; Jimmy X Tang; Jin-Yan Tang; Cathrine F Knetter; Egil Lien; Sudhir Agrawal
A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14303-8.
2003: Yan-Ping Cong; Sam S Song; Lakshmi Bhagat; Rajendra K Pandey; Dong Yu; Ekambar R Kandimalla; Sudhir Agrawal
Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells.
Biochemical and biophysical research communications 2003;310(4):1133-9.
2003: Ekambar R Kandimalla; Lakshmi Bhagat; Yan-Ping Cong; Rajendra K Pandey; Dong Yu; Qiuyan Zhao; Sudhir Agrawal
Secondary structures in CpG oligonucleotides affect immunostimulatory activity.
Biochemical and biophysical research communications 2003;306(4):948-53.
2003: Ekambar R Kandimalla; Fu-Gang Zhu; Lakshmi Bhagat; Dong Yu; Sudhir Agrawal
Toll-like receptor 9: modulation of recognition and cytokine induction by novel synthetic CpG DNAs.
Biochemical Society transactions 2003;31(Pt 3):654-8.
2003: Ekambar R Kandimalla; Lakshmi Bhagat; Daqing Wang; Dong Yu; Fu-Gang Zhu; Jimmy Tang; Hui Wang; Ping Huang; Ruiwen Zhang; Sudhir Agrawal
Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles.
Nucleic acids research 2003;31(9):2393-400.
2003: Dong Yu; Ekambar R Kandimalla; Qiuyan Zhao; Lakshmi Bhagat; Yanping Cong; Sudhir Agrawal
Requirement of nucleobase proximal to CpG dinucleotide for immunostimulatory activity of synthetic CpG DNA.
Bioorganic & medicinal chemistry 2003;11(3):459-64.
2003: Lakshmi Bhagat; Fu-Gang Zhu; Dong Yu; Jimmy Tang; Hui Wang; Ekambar R Kandimalla; Ruiwen Zhang; Sudhir Agrawal
CpG penta- and hexadeoxyribonucleotides as potent immunomodulatory agents.
Biochemical and biophysical research communications 2003;300(4):853-61.
2002: Dong Yu; Ekambar R Kandimalla; Lakshmi Bhagat; Jin-Yan Tang; Yanping Cong; Jimmy Tang; Sudhir Agrawal
'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents.
Nucleic acids research 2002;30(20):4460-9.
2002: Dong Yu; Ekambar R Kandimalla; Yanping Cong; Jimmy Tang; Jin-Yan Tang; Qiuyan Zhao; Sudhir Agrawal
Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences.
Journal of medicinal chemistry 2002;45(20):4540-8.
2002: Dong Yu; Fu-Gang Zhu; Lakshmi Bhagat; Hui Wang; Ekambar R Kandimalla; Ruiwen Zhang; Sudhir Agrawal
Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties.
Biochemical and biophysical research communications 2002;297(1):83-90.
2002: Ekambar R Kandimalla; Lakshmi Bhagat; Dong Yu; Yanping Cong; Jimmy Tang; Sudhir Agrawal
Conjugation of ligands at the 5'-end of CpG DNA affects immunostimulatory activity.
Bioconjugate chemistry 2002;13(5):966-74.
2002: Dong Yu; Ekambar R Kandimalla; Qiuyan Zhao; Yanping Cong; Sudhir Agrawal
Immunostimulatory properties of phosphorothioate CpG DNA containing both 3'-5'- and 2'-5'-internucleotide linkages.
Nucleic acids research 2002;30(7):1613-9.
2002: Sudhir Agrawal; Ekambar R Kandimalla
Medicinal chemistry and therapeutic potential of CpG DNA.
Trends in molecular medicine 2002;8(3):114-21.
2001: Sudhir Agrawal; Ekambar R Kandimalla
Antisense and/or immunostimulatory oligonucleotide therapeutics.
Current cancer drug targets 2001;1(3):197-209.
2001: Dong Yu; Ekambar R Kandimalla; Qiuyan Zhao; Yanping Cong; Sudhir Agrawal
Modulation of immunostimulatory activity of CpG oligonucleotides by site-specific deletion of nucleobases.
Bioorganic & medicinal chemistry letters 2001;11(17):2263-7.
2001: Ekambar R Kandimalla; Dong Yu; Q Zhao; Sudhir Agrawal
Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.
Bioorganic & medicinal chemistry 2001;9(3):807-13.
2000: Dong Yu; Q Zhao; Ekambar R Kandimalla; Sudhir Agrawal
Accessible 5'-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity.
Bioorganic & medicinal chemistry letters 2000;10(23):2585-8.
1998: Q Zhao; R Zhou; J Temsamani; Z Zhang; A Roskey; Sudhir Agrawal
Cellular distribution of phosphorothioate oligonucleotide following intravenous administration in mice.
Antisense & nucleic acid drug development 1998;8(6):451-8.
1998: L X Shen; Ekambar R Kandimalla; Sudhir Agrawal
Impact of mixed-backbone oligonucleotides on target binding affinity and target cleaving specificity and selectivity by Escherichia coli RNase H.
Bioorganic & medicinal chemistry 1998;6(10):1695-705.
1998: Ekambar R Kandimalla; Denise R Shaw; Sudhir Agrawal
Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation.
Bioorganic & medicinal chemistry letters 1998;8(16):2103-8.
1998: Sudhir Agrawal; Q Zhao
Mixed backbone oligonucleotides: improvement in oligonucleotide-induced toxicity in vivo.
Antisense & nucleic acid drug development 1998;8(2):135-9.
1998: J M Grindel; T J Musick; Z Jiang; A Roskey; Sudhir Agrawal
Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion.
Antisense & nucleic acid drug development 1998;8(1):43-52.
1998: Sudhir Agrawal; X Zhang; Q Cai; Ekambar R Kandimalla; A Manning; Z Jiang; T Marcel; R Zhang
Effect of aspirin on protein binding and tissue disposition of oligonucleotide phosphorothioate in rats.
Journal of drug targeting 1998;5(4):303-12.
1997: Sudhir Agrawal; Q Zhao; Z Jiang; C Oliver; H Giles; J Heath; D Serota
Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats.
Antisense & nucleic acid drug development 1997;7(6):575-84.
1997: Q Zhao; J Temsamani; R Z Zhou; Sudhir Agrawal
Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice.
Antisense & nucleic acid drug development 1997;7(5):495-502.
1997: Sudhir Agrawal; W Tan; Q Cai; X Xie; R Zhang
In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines.
Antisense & nucleic acid drug development 1997;7(3):245-9.
1997: J Temsamani; A Roskey; C Chaix; Sudhir Agrawal
In vivo metabolic profile of a phosphorothioate oligodeoxyribonucleotide.
Antisense & nucleic acid drug development 1997;7(3):159-65.