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Karen Pollok

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Timmy Mani; Inha Jo; David R Jones; May Khanna; Rajesh Khanna; William Eric Knabe; Karen E Pollok; George E Sandusky; Anthony L Sinn; George W Sledge; Fang Wang; Samy O Meroueh
Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis.
Fang Wang; Inha Jo; David R Jones; May Khanna; W Eric Knabe; Jing Li; Liwei Li; Harikrishna Nakshatri; Kyungsoo Oh; Karen E Pollok; George E Sandusky; Jayne M Silver; Anthony L Sinn; George W Sledge; Samy O Meroueh
Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis.
Melissa L Fishel; Ying He; Mircea Ivan; Yanlin Jiang; David R Jones; Anirban Maitra; Karen E Pollok; N V Rajeshkumar; Glenda Scandura; Changyu Shen; Anthony L Sinn; Mark R Kelley
Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth.

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All Publications

2013: Timmy Mani; Inha Jo; David R Jones; May Khanna; Rajesh Khanna; William Eric Knabe; Karen E Pollok; George E Sandusky; Anthony L Sinn; George W Sledge; Fang Wang; Samy O Meroueh
Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis.
Bioorganic & medicinal chemistry 2013;21(7):2145-55.
2011: Fang Wang; Inha Jo; David R Jones; May Khanna; W Eric Knabe; Jing Li; Liwei Li; Harikrishna Nakshatri; Kyungsoo Oh; Karen E Pollok; George E Sandusky; Jayne M Silver; Anthony L Sinn; George W Sledge; Samy O Meroueh
Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis.
Journal of medicinal chemistry 2011;54(20):7193-205.
2011: Melissa L Fishel; Ying He; Mircea Ivan; Yanlin Jiang; David R Jones; Anirban Maitra; Karen E Pollok; N V Rajeshkumar; Glenda Scandura; Changyu Shen; Anthony L Sinn; Mark R Kelley
Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth.
Molecular cancer therapeutics 2011;10(9):1698-708.
2011: Shanbao Cai; Haiyan Wang; Barbara Bailey; Aaron Ernstberger; Beth E Juliar; Anthony L Sinn; Rebecca J Chan; David R Jones; Lindsey D Mayo; Arthur R Baluyut; W Scott Goebel; Karen E Pollok
Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2195-206.
2011: Shanbao Cai; Jennifer R Hartwell; Beth E Juliar; Barbara Bailey; Arthur R Baluyut; Jayne M Silver; Anthony L Sinn; Haiyan Wang; Karen E Pollok
Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice.
Bone marrow research 2011;2011():252953.
2009: Travis W Day; Anthony L Sinn; Su Huang; Karen E Pollok; George E Sandusky; Ahmad R Safa
c-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells.
Anticancer research 2009;29(10):3883-6.
2009: Brandon K Wyss; Abigail F W Donnelly; Dan Zhou; Anthony L Sinn; Karen E Pollok; W Scott Goebel
Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A.
Experimental hematology 2009;37(7):814-23.
2009: Karen E Pollok; Michael Lahn; Nathan Enas; Ann McNulty; Jeremy Graff; Shanbao Cai; Jennifer R Hartwell; Aaron Ernstberger; Donald Thornton; Les Brail; Gary Hutchins
In Vivo Measurements of Tumor Metabolism and Growth after Administration of Enzastaurin Using Small Animal FDG Positron Emission Tomography.
Journal of oncology 2009;2009():596560.
2008: Ying Liu; Giao Hangoc; Timothy B Campbell; Michael Goodman; Wen Tao; Karen E Pollok; Edward F Srour; Hal E Broxmeyer
Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells.
Experimental hematology 2008;36(8):947-56.
2008: Qiwei Zhang; Yongxue David Yao; Raymond L Konger; Anthony L Sinn; Shanbao Cai; Karen E Pollok; Jeffrey B Travers
UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system.
The Journal of investigative dermatology 2008;128(7):1780-7.
2008: Shanbao Cai; Aaron Ernstberger; Haiyan Wang; Barbara J Bailey; Jennifer R Hartwell; Anthony L Sinn; Olaf Eckermann; Yvonne Linka; W Scott Goebel; Helmut Hanenberg; Karen E Pollok
In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMT(P140K) vector.
Experimental hematology 2008;36(3):283-92.
2007: Timothy B Campbell; Giao Hangoc; Ying Liu; Karen E Pollok; Hal E Broxmeyer
Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice.
Stem cells and development 2007;16(3):347-54.
2007: Joshua L Fischer; Elaine M Mihelc; Karen E Pollok; Martin L Smith
Chemotherapeutic selectivity conferred by selenium: a role for p53-dependent DNA repair.
Molecular cancer therapeutics 2007;6(1):355-61.
2006: Shangming Zhang; Guiandre Joseph; Karen E Pollok; Lionel Berthoux; Lakshmi Sastry; Jeremy Luban; Kenneth Cornetta
G2 cell cycle arrest and cyclophilin A in lentiviral gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(4):546-54.
2006: Shanbao Cai; Jennifer R Hartwell; Ryan J Cooper; Beth E Juliar; Emiko Lynn Kreklau; Rafat Abonour; W Scott Goebel; Karen E Pollok
In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(5):1016-26.
2006: Ji-Quan Wang; Karen E Pollok; Shanbao Cai; Keith M Stantz; Gary D Hutchins; Qi-Huang Zheng
PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice.
Bioorganic & medicinal chemistry letters 2006;16(2):331-7.
2005: Shanbao Cai; Yi Xu; Ryan J Cooper; Michael J Ferkowicz; Jennifer R Hartwell; Karen E Pollok; Mark R Kelley
Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
Cancer research 2005;65(8):3319-27.
2005: Christoph Kahl; Karen E Pollok; Laura S Haneline; Kenneth Cornetta
Lentiviral vectors pseudotyped with glycoproteins from Ross River and vesicular stomatitis viruses: variable transduction related to cell type and culture conditions.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(3):470-82.
2004: David A Ingram; Laura E Mead; Hiromi Tanaka; Virginia Meade; Amy Fenoglio; Kelly Mortell; Karen E Pollok; Michael J Ferkowicz; David Gilley; Mervin C Yoder
Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood.
Blood 2004;104(9):2752-60.
2004: Lakshmi Sastry; Yi Xu; Ryan Cooper; Karen E Pollok; Kenneth Cornetta
Evaluation of plasmid DNA removal from lentiviral vectors by benzonase treatment.
Human gene therapy 2004;15(2):221-6.
2003: Karen E Pollok; Jennifer R Hartwell; Annemarije Braber; Ryan J Cooper; Michael Jansen; Susanne Ragg; Barbara J Bailey; Leonard C Erickson; Emiko Lynn Kreklau; David A Williams
In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations.
Human gene therapy 2003;14(18):1703-14.
2003: Emiko Lynn Kreklau; Karen E Pollok; Barbara J Bailey; Naili Liu; Jennifer R Hartwell; David A Williams; Leonard C Erickson
Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
Molecular cancer therapeutics 2003;2(12):1321-9.
2003: Karen E Pollok
In vivo protection of hematopoietic cells from alkylator-mediated DNA damage.
Current hematology reports 2003;2(4):341-7.
2003: Erik J Woods; Jun Liu; Karen E Pollok; Jennifer R Hartwell; Franklin O Smith; David A Williams; Mervin C Yoder; John K Critser
A theoretically optimized method for cord blood stem cell cryopreservation.
Journal of hematotherapy & stem cell research 2003;12(3):341-50.
2003: Cordula Leurs; Michael Jansen; Karen E Pollok; Martin Heinkelein; Manfred Schmidt; Manuela Wissler; Dirk Lindemann; Christof von Kalle; Axel Rethwilm; David A Williams; Helmut Hanenberg
Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.
Human gene therapy 2003;14(6):509-19.
2002: Helmut Hanenberg; Sat Dev Batish; Karen E Pollok; Lydia Vieten; Peter C Verlander; Cordula Leurs; Ryan J Cooper; Kerstin Göttsche; Laura S Haneline; D Wade Clapp; Stephan Lobitz; David A Williams; Arleen D Auerbach
Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool.
Experimental hematology 2002;30(5):410-20.
2001: Karen E Pollok; JC van der Loo; Ryan J Cooper; Jennifer R Hartwell; K R Miles; Robert Breese; E P Williams; A Montel; R Seshadri; Helmut Hanenberg; David A Williams
Differential transduction efficiency of SCID-repopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood.
Human gene therapy 2001;12(17):2095-108.
1999: Qi Sun; Karen E Pollok; Robert L Burton; L J Dai; W Britt; DJ Emanuel; Kenneth G Lucas
Simultaneous ex vivo expansion of cytomegalovirus and Epstein-Barr virus-specific cytotoxic T lymphocytes using B-lymphoblastoid cell lines expressing cytomegalovirus pp65.
Blood 1999;94(9):3242-50.
1999: Karen E Pollok; David A Williams
Facilitation of retrovirus-mediated gene transfer into hematopoietic stem and progenitor cells and peripheral blood T-lymphocytes utilizing recombinant fibronectin fragments.
Current opinion in molecular therapeutics 1999;1(5):595-604.
1999: Karen E Pollok; JC van der Loo; Ryan J Cooper; L Kennedy; David A Williams
Costimulation of transduced T lymphocytes via T cell receptor-CD3 complex and CD28 leads to increased transcription of integrated retrovirus.
Human gene therapy 1999;10(13):2221-36.
1999: Qi Sun; Robert L Burton; Karen E Pollok; DJ Emanuel; Kenneth G Lucas
CD4(+) Epstein-Barr virus-specific cytotoxic T-lymphocytes from human umbilical cord blood.
Cellular immunology 1999;195(2):81-8.
1999: E C MacNeill; Helmut Hanenberg; Karen E Pollok; JC van der Loo; MF Bierhuizen; Gerard Wagemaker; David A Williams
Simultaneous infection with retroviruses pseudotyped with different envelope proteins bypasses viral receptor interference associated with colocalization of gp70 and target cells on fibronectin CH-296.
Journal of virology 1999;73(5):3960-7.
1998: Karen E Pollok; Helmut Hanenberg; T W Noblitt; W L Schroeder; I Kato; DJ Emanuel; David A Williams
High-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragments.
Journal of virology 1998;72(6):4882-92.
1997: Kenneth G Lucas; Robert Burton; Douglas K Heilman; Karen E Pollok; DJ Emanuel
Cord blood mononuclear cell transformation assay for screening for the presence of Epstein-Barr virus.
Journal of hematotherapy 1997;6(6):587-90.
1997: DJ Emanuel; Kenneth G Lucas; G B Mallory; M K Edwards-Brown; Karen E Pollok; P D Conrad; Kent A Robertson; Franklin O Smith
Treatment of posttransplant lymphoproliferative disease in the central nervous system of a lung transplant recipient using allogeneic leukocytes.
Transplantation 1997;63(11):1691-4.
1997: Kenneth G Lucas; Karen E Pollok; DJ Emanuel
Post-transplant EBV induced lymphoproliferative disorders.
Leukemia & lymphoma 1997;25(1-2):1-8.
1995: J C Hurtado; S H Kim; Karen E Pollok; Z H Lee; Byoung S Kwon
Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3360-7.
1995: Mark DeBenedette; N R Chu; Karen E Pollok; J Hurtado; William F Wade; Byoung S Kwon; Tania H Watts
Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP.
The Journal of experimental medicine 1995;181(3):985-92.
1995: Z Zhou; S Kim; J Hurtado; Z H Lee; K K Kim; Karen E Pollok; Byoung S Kwon
Characterization of human homologue of 4-1BB and its ligand.
Immunology letters 1995;45(1-2):67-73.
1994: Z Zhou; Karen E Pollok; K K Kim; Young-June Kim; Byoung S Kwon
Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes.
Immunology letters 1994;41(2-3):177-84.
1994: Karen E Pollok; Young-June Kim; J Hurtado; Z Zhou; K K Kim; Byoung S Kwon
4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells.
European journal of immunology 1994;24(2):367-74.
1993: Z Zhou; Young-June Kim; Karen E Pollok; J Hurtado; J K Lee; Hal E Broxmeyer; Byoung S Kwon
Macrophage inflammatory protein-1 alpha rapidly modulates its receptors and inhibits the anti-CD3 mAb-mediated proliferation of T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4333-41.
1993: Young-June Kim; Karen E Pollok; Z Zhou; A Shaw; J B Bohlen; M Fraser; Byoung S Kwon
Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1255-62.
1993: Karen E Pollok; Young-June Kim; Z Zhou; J Hurtado; K K Kim; R T Pickard; Byoung S Kwon
Inducible T cell antigen 4-1BB. Analysis of expression and function.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):771-81.