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Kenneth Polonsky

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Kawai Toshihide; Ng Maggie C Y; Hayes M Geoffrey; Yoshiuchi Issei; Tsuchiya Takafumi; Robertson Heather; Cox Nancy J; Polonsky Kenneth S; Bell Graeme I; Ehrmann David A
Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
Fujimoto K; Polonsky K S
Pdx1 and other factors that regulate pancreatic beta-cell survival.
Fujimoto Kei; Hanson Piia T; Tran Hung; Ford Eric L; Han Zhiqiang; Johnson James D; Schmidt Robert E; Green Karen G; Wice Burton M; Polonsky Kenneth S
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.

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All Publications

2009: Kawai Toshihide; Ng Maggie C Y; Hayes M Geoffrey; Yoshiuchi Issei; Tsuchiya Takafumi; Robertson Heather; Cox Nancy J; Polonsky Kenneth S; Bell Graeme I; Ehrmann David A
Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
Diabetes research and clinical practice 2009;86(3):186-92.
2009: Fujimoto K; Polonsky K S
Pdx1 and other factors that regulate pancreatic beta-cell survival.
Diabetes, obesity & metabolism 2009;11 Suppl 4():30-7.
2009: Fujimoto Kei; Hanson Piia T; Tran Hung; Ford Eric L; Han Zhiqiang; Johnson James D; Schmidt Robert E; Green Karen G; Wice Burton M; Polonsky Kenneth S
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
The Journal of biological chemistry 2009;284(40):27664-73.
2009: Villareal Dennis T; Koster Joseph C; Robertson Heather; Akrouh Alejandro; Miyake Kazuaki; Bell Graeme I; Patterson Bruce W; Nichols Colin G; Polonsky Kenneth S
Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.
Diabetes 2009;58(8):1869-78.
2009: Muslin Anthony J; Kornfeld Stuart; Polonsky Kenneth S
The physician scientist training program in internal medicine at Washington University School of Medicine.
Academic medicine : journal of the Association of American Medical Colleges 2009;84(4):468-71.
2009: Uchizono Yuji; Baldwin Aaron C; Sakuma Hiroya; Pugh William; Polonsky Kenneth S; Hara Manami
Role of HNF-1alpha in regulating the expression of genes involved in cellular growth and proliferation in pancreatic beta-cells.
Diabetes research and clinical practice 2009;84(1):19-26.
2008: Polonsky Kenneth S; Klein Samuel
Gastric banding to treat obesity: band-aid or breakthrough?
Nature clinical practice. Endocrinology & metabolism 2008;4(8):421.
2008: Jeffrey Kristin D; Alejandro Emilyn U; Luciani Dan S; Kalynyak Tatyana B; Hu Xiaoke; Li Hong; Lin Yalin; Townsend R Reid; Polonsky Kenneth S; Johnson James D
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8452-7.
2008: Little Randie R; Rohlfing Curt L; Tennill Alethea L; Madsen Richard W; Polonsky Kenneth S; Myers Gary L; Greenbaum Carla J; Palmer Jerry P; Rogatsky Eduard; Stein Daniel T
Standardization of C-peptide measurements.
Clinical chemistry 2008;54(6):1023-6.
2008: Althage Matthew C; Ford Eric L; Wang Songyan; Tso Patrick; Polonsky Kenneth S; Wice Burton M
Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.
The Journal of biological chemistry 2008;283(26):18365-76.
2008: Villareal Dennis T; Banks Marian R; Patterson Bruce W; Polonsky Kenneth S; Klein Samuel
Weight loss therapy improves pancreatic endocrine function in obese older adults.
Obesity (Silver Spring, Md.) 2008;16(6):1349-54.
2007: Hara M; Shen J; Pugh W; Polonsky K S; Le Beau M M; Bell G I
Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007;115(10):654-61.
2007: Wiedmeyer Hsiao-Mei; Polonsky Kenneth S; Myers Gary L; Little Randie R; Greenbaum Carla J; Goldstein David E; Palmer Jerry P
International comparison of C-peptide measurements.
Clinical chemistry 2007;53(4):784-7.
2006: Johnson James D; Bernal-Mizrachi Ernesto; Alejandro Emilyn U; Han Zhiqiang; Kalynyak Tatyana B; Li Hong; Beith Jennifer L; Gross Julia; Warnock Garth L; Townsend R Reid; Permutt M Alan; Polonsky Kenneth S
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19575-80.
2006: Johnson James D; Ford Eric L; Bernal-Mizrachi Ernesto; Kusser Kim L; Luciani Dan S; Han Zhiqiang; Tran Hung; Randall Troy D; Lund Frances E; Polonsky Kenneth S
Suppressed insulin signaling and increased apoptosis in CD38-null islets.
Diabetes 2006;55(10):2737-46.
2006: Shapiro A M James; Ricordi Camillo; Hering Bernhard J; Auchincloss Hugh; Lindblad Robert; Robertson R Paul; Secchi Antonio; Brendel Mathias D; Berney Thierry; Brennan Daniel C; Cagliero Enrico; Alejandro Rodolfo; Ryan Edmond A; DiMercurio Barbara; Morel Philippe; Polonsky Kenneth S; Reems Jo-Anna; Bretzel Reinhard G; Bertuzzi Federico; Froud Tatiana; Kandaswamy Raja; Sutherland David E R; Eisenbarth George; Segal Miriam; Preiksaitis Jutta; Korbutt Gregory S; Barton Franca B; Viviano Lisa; Seyfert-Margolis Vicki; Bluestone Jeffrey; Lakey Jonathan R T
International trial of the Edmonton protocol for islet transplantation.
The New England journal of medicine 2006;355(13):1318-30.
2006: Otani Kenichi; Polonsky Kenneth S; Holloszy John O; Han Dong-Ho
Inhibition of calpain results in impaired contraction-stimulated GLUT4 translocation in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E544-8.
2006: Mohanakumar T; Narayanan Kishore; Desai Niraj; Ramachandran Sabarinathan; Shenoy Surendra; Jendrisak Martin; Susskind Brian M; Olack Barbara; Benshoff Nicholas; Phelan Donna L; Brennan Daniel C; Fernandez Luis A; Odorico Jon S; Polonsky Kenneth S
A significant role for histocompatibility in human islet transplantation.
Transplantation 2006;82(2):180-7.
2006: Polonsky Kenneth S
Retinol-binding protein 4, insulin resistance, and type 2 diabetes.
The New England journal of medicine 2006;354(24):2596-8.
2006: Luciani Dan S; Misler Stanley; Polonsky Kenneth S
Ca2+ controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets.
The Journal of physiology 2006;572(Pt 2):379-92.
2005: Dalla Man Chiara; Yarasheski Kevin E; Caumo Andrea; Robertson Heather; Toffolo Gianna; Polonsky Kenneth S; Cobelli Claudio
Insulin sensitivity by oral glucose minimal models: validation against clamp.
American journal of physiology. Endocrinology and metabolism 2005;289(6):E954-9.
2005: Dalla Man Chiara; Campioni Marco; Polonsky Kenneth S; Basu Rita; Rizza Robert A; Toffolo Gianna; Cobelli Claudio
Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals.
Diabetes 2005;54(11):3265-73.
2005: Levisetti Matteo G; Polonsky Kenneth S
Diabetic pancreatic beta cells ARNT all they should be.
Cell metabolism 2005;2(2):78-80.
2005: Kim Sun H; Abbasi Fahim; Chu James W; McLaughlin Tracey L; Lamendola Cindy; Polonsky Kenneth S; Reaven Gerald M
Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic, insulin-resistant individuals.
Diabetes 2005;54(8):2447-52.
2005: Ohsugi Mitsuru; Cras-Méneur Corentin; Zhou Yiyong; Bernal-Mizrachi Ernesto; Johnson James D; Luciani Dan S; Polonsky Kenneth S; Permutt M Alan
Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
The Journal of biological chemistry 2005;280(6):4992-5003.
2004: Bernal-Mizrachi Ernesto; Fatrai Szabolcs; Johnson James D; Ohsugi Mitsuru; Otani Kenichi; Han Zhiqiang; Polonsky Kenneth S; Permutt M Alan
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
The Journal of clinical investigation 2004;114(7):928-36.
2004: Ehrmann David A; Breda Elena; Corcoran Matthew C; Cavaghan Melissa K; Imperial Jacqueline; Toffolo Gianna; Cobelli Claudio; Polonsky Kenneth S
Impaired beta-cell compensation to dexamethasone-induced hyperglycemia in women with polycystic ovary syndrome.
American journal of physiology. Endocrinology and metabolism 2004;287(2):E241-6.
2004: Brennan Daniel C; Shannon M Brendan; Koch Matthew J; Polonsky Kenneth S; Desai Niraj; Shapiro James
Portal vein thrombosis complicating islet transplantation in a recipient with the Factor V Leiden mutation.
Transplantation 2004;78(1):172-3.
2004: Johnson James D; Han Zhiqiang; Otani Kenichi; Ye Honggang; Zhang Yan; Wu Hong; Horikawa Yukio; Misler Stanley; Bell Graeme I; Polonsky Kenneth S
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
The Journal of biological chemistry 2004;279(23):24794-802.
2004: Johnson James D; Kuang Shihuan; Misler Stanley; Polonsky Kenneth S
Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):878-80.
2004: Otani Kenichi; Han Dong-Ho; Ford Eric L; Garcia-Roves Pablo M; Ye Honggang; Horikawa Yukio; Bell Graeme I; Holloszy John O; Polonsky Kenneth S
Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.
The Journal of biological chemistry 2004;279(20):20915-20.
2004: Palmer Jerry P; Fleming G Alexander; Greenbaum Carla J; Herold Kevan C; Jansa Lisa D; Kolb Hubert; Lachin John M; Polonsky Kenneth S; Pozzilli Paolo; Skyler Jay S; Steffes Michael W
C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.
Diabetes 2004;53(1):250-64.
2004: Mathews Vikram; Hanson Piia T; Ford Eric; Fujita Jun; Polonsky Kenneth S; Graubert Timothy A
Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury.
Diabetes 2004;53(1):91-8.
2004: Otani Kenichi; Kulkarni Rohit N; Baldwin Aaron C; Krutzfeldt Jan; Ueki Kohjiro; Stoffel Markus; Kahn C Ronald; Polonsky Kenneth S
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.
American journal of physiology. Endocrinology and metabolism 2004;286(1):E41-9.
2003: Jackson Robert S; Creemers John W M; Farooqi I Sadaf; Raffin-Sanson Marie-Laure; Varro Andrea; Dockray Graham J; Holst Jens J; Brubaker Patricia L; Corvol Pierre; Polonsky Kenneth S; Ostrega Diane; Becker Kenneth L; Bertagna Xavier; Hutton John C; White Anne; Dattani Mehul T; Hussain Khalid; Middleton Stephen J; Nicole Thomasina M; Milla Peter J; Lindley Keith J; O'Rahilly Stephen
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
The Journal of clinical investigation 2003;112(10):1550-60.
2003: Zhou Yun-Ping; Sreenan Seamus; Pan Chien-Yuan; Currie Kevin P M; Bindokas Vytautas P; Horikawa Yukio; Lee Jean-Pyo; Ostrega Diane; Ahmed Noreen; Baldwin Aaron C; Cox Nancy J; Fox Aaron P; Miller Richard J; Bell Graeme I; Polonsky Kenneth S
A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
Metabolism: clinical and experimental 2003;52(5):528-34.
2003: Polonsky Kenneth S; Bell Graeme I
Organ alchemy: producing insulin in the liver.
Nature medicine 2003;9(5):504-5.
2003: Johnson James D; Ahmed Noreen T; Luciani Dan S; Han Zhiqiang; Tran Hung; Fujita Jun; Misler Stanley; Edlund Helena; Polonsky Kenneth S
Increased islet apoptosis in Pdx1+/- mice.
The Journal of clinical investigation 2003;111(8):1147-60.
2003: Bindokas Vytautas P; Kuznetsov Andrey; Sreenan Seamus; Polonsky Kenneth S; Roe Michael W; Philipson Louis H
Visualizing superoxide production in normal and diabetic rat islets of Langerhans.
The Journal of biological chemistry 2003;278(11):9796-801.
2002: Attele Anoja S; Zhou Yun-Ping; Xie Jing-Tian; Wu Ji An; Zhang Liu; Dey Lucy; Pugh William; Rue Paul A; Polonsky Kenneth S; Yuan Chun-Su
Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.
Diabetes 2002;51(6):1851-8.
2002: Xie J T; Zhou Y P; Dey L; Attele A S; Wu J A; Gu M; Polonsky K S; Yuan C S
Ginseng berry reduces blood glucose and body weight in db/db mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2002;9(3):254-8.
2002: Ehrmann D A; Breda E; Cavaghan M K; Bajramovic S; Imperial J; Toffolo G; Cobelli C; Polonsky K S
Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance.
Diabetologia 2002;45(4):509-17.
2002: Hofmann Elisa A; Polonsky Kenneth S; Weiss Roy E
Diagnosis of acromegaly in a patient with type 1 diabetes mellitus.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2002;8(2):113-8.
2002: Breda Elena; Toffolo Gianna; Polonsky Kenneth S; Cobelli Claudio
Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times.
Diabetes 2002;51 Suppl 1():S227-33.
2001: Bell G I; Polonsky K S
Diabetes mellitus and genetically programmed defects in beta-cell function.
Nature 2001;414(6865):788-91.
2001: Shih D Q; Screenan S; Munoz K N; Philipson L; Pontoglio M; Yaniv M; Polonsky K S; Stoffel M
Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
Diabetes 2001;50(11):2472-80.
2001: Tuttle R L; Gill N S; Pugh W; Lee J P; Koeberlein B; Furth E E; Polonsky K S; Naji A; Birnbaum M J
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.
Nature medicine 2001;7(10):1133-7.
2001: Fajans S S; Bell G I; Polonsky K S
Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
The New England journal of medicine 2001;345(13):971-80.
2001: Sreenan S K; Zhou Y P; Otani K; Hansen P A; Currie K P; Pan C Y; Lee J P; Ostrega D M; Pugh W; Horikawa Y; Cox N J; Hanis C L; Burant C F; Fox A P; Bell G I; Polonsky K S
Calpains play a role in insulin secretion and action.
Diabetes 2001;50(9):2013-20.
2001: Gautier J F; Wilson C; Weyer C; Mott D; Knowler W C; Cavaghan M; Polonsky K S; Bogardus C; Pratley R E
Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes.
Diabetes 2001;50(8):1828-33.
2001: Brandt A; Katschinski M; Arnold R; Polonsky K S; Göke B; Byrne M M
GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve.
American journal of physiology. Endocrinology and metabolism 2001;281(2):E242-7.
2001: Polonsky K S; Semenkovich C F
The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes.
Cell 2001;105(6):705-7.
2001: Grimberg A; Ferry R J; Kelly A; Koo-McCoy S; Polonsky K; Glaser B; Permutt M A; Aguilar-Bryan L; Stafford D; Thornton P S; Baker L; Stanley C A
Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations.
Diabetes 2001;50(2):322-8.
2001: Breda E; Cavaghan M K; Toffolo G; Polonsky K S; Cobelli C
Oral glucose tolerance test minimal model indexes of beta-cell function and insulin sensitivity.
Diabetes 2001;50(1):150-8.
2001: Toffolo G; Breda E; Cavaghan M K; Ehrmann D A; Polonsky K S; Cobelli C
Quantitative indexes of beta-cell function during graded up&down glucose infusion from C-peptide minimal models.
American journal of physiology. Endocrinology and metabolism 2001;280(1):E2-10.
2000: Sreenan S K; Mittal A A; Dralyuk F; Pugh W L; Polonsky K S; Roe M W
Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans.
Metabolism: clinical and experimental 2000;49(12):1579-87.
2000: Horikawa Y; Oda N; Cox N J; Li X; Orho-Melander M; Hara M; Hinokio Y; Lindner T H; Mashima H; Schwarz P E; del Bosque-Plata L; Horikawa Y; Oda Y; Yoshiuchi I; Colilla S; Polonsky K S; Wei S; Concannon P; Iwasaki N; Schulze J; Baier L J; Bogardus C; Groop L; Boerwinkle E; Hanis C L; Bell G I
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
Nature genetics 2000;26(2):163-75.
2000: Chin-Chance C; Polonsky K S; Schoeller D A
Twenty-four-hour leptin levels respond to cumulative short-term energy imbalance and predict subsequent intake.
The Journal of clinical endocrinology and metabolism 2000;85(8):2685-91.
2000: Cavaghan M K; Ehrmann D A; Polonsky K S
Interactions between insulin resistance and insulin secretion in the development of glucose intolerance.
The Journal of clinical investigation 2000;106(3):329-33.
2000: Hollingdal M; Juhl C B; Pincus S M; Sturis J; Veldhuis J D; Polonsky K S; Pørksen N; Schmitz O
Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.
Diabetes 2000;49(8):1334-40.
2000: Polonsky K S
Dynamics of insulin secretion in obesity and diabetes.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 2():S29-31.
2000: Jones C N; Abbasi F; Carantoni M; Polonsky K S; Reaven G M
Roles of insulin resistance and obesity in regulation of plasma insulin concentrations.
American journal of physiology. Endocrinology and metabolism 2000;278(3):E501-8.
2000: Zhou Y P; Pena J C; Roe M W; Mittal A; Levisetti M; Baldwin A C; Pugh W; Ostrega D; Ahmed N; Bindokas V P; Philipson L H; Hanahan D; Thompson C B; Polonsky K S
Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.
American journal of physiology. Endocrinology and metabolism 2000;278(2):E340-51.
1999: Plat L; Leproult R; L'Hermite-Baleriaux M; Fery F; Mockel J; Polonsky K S; Van Cauter E
Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning.
The Journal of clinical endocrinology and metabolism 1999;84(9):3082-92.
1999: Zhou Y P; Cockburn B N; Pugh W; Polonsky K S
Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.
Metabolism: clinical and experimental 1999;48(7):857-64.
1999: Sreenan S; Pick A J; Levisetti M; Baldwin A C; Pugh W; Polonsky K S
Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.
Diabetes 1999;48(5):989-96.
1999: Wiesenthal S R; Sandhu H; McCall R H; Tchipashvili V; Yoshii H; Polonsky K; Shi Z Q; Lewis G F; Mari A; Giacca A
Free fatty acids impair hepatic insulin extraction in vivo.
Diabetes 1999;48(4):766-74.
1999: Polonsky K S
Evolution of beta-cell dysfunction in impaired glucose tolerance and diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1999;107 Suppl 4():S124-7.
1998: Sreenan S K; Cockburn B N; Baldwin A C; Ostrega D M; Levisetti M; Grupe A; Bell G I; Stewart T A; Roe M W; Polonsky K S
Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.
Diabetes 1998;47(12):1881-8.
1998: Dukes I D; Sreenan S; Roe M W; Levisetti M; Zhou Y P; Ostrega D; Bell G I; Pontoglio M; Yaniv M; Philipson L; Polonsky K S
Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice.
The Journal of biological chemistry 1998;273(38):24457-64.
1998: Byrne M M; Gliem K; Wank U; Arnold R; Katschinski M; Polonsky K S; Göke B
Glucagon-like peptide 1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance.
Diabetes 1998;47(8):1259-65.
1998: Pontoglio M; Sreenan S; Roe M; Pugh W; Ostrega D; Doyen A; Pick A J; Baldwin A; Velho G; Froguel P; Levisetti M; Bonner-Weir S; Bell G I; Yaniv M; Polonsky K S
Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.
The Journal of clinical investigation 1998;101(10):2215-22.
1998: Zhou Y P; Teng D; Dralyuk F; Ostrega D; Roe M W; Philipson L; Polonsky K S
Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism.
The Journal of clinical investigation 1998;101(8):1623-32.
1998: Pick A; Clark J; Kubstrup C; Levisetti M; Pugh W; Bonner-Weir S; Polonsky K S
Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.
Diabetes 1998;47(3):358-64.
1998: McCall R H; Wiesenthal S R; Shi Z Q; Polonsky K; Giacca A
Insulin acutely suppresses glucose production by both peripheral and hepatic effects in normal dogs.
The American journal of physiology 1998;274(2 Pt 1):E346-56.
1998: Maggs D G; Buchanan T A; Burant C F; Cline G; Gumbiner B; Hsueh W A; Inzucchi S; Kelley D; Nolan J; Olefsky J M; Polonsky K S; Silver D; Valiquett T R; Shulman G I
Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.
Annals of internal medicine 1998;128(3):176-85.
1998: Polonsky K S; Sturis J; Van Cauter E
Temporal profiles and clinical significance of pulsatile insulin secretion.
Hormone research 1998;49(3-4):178-84.
1997: Maheux P; Chen Y D; Polonsky K S; Reaven G M
Evidence that insulin can directly inhibit hepatic glucose production.
Diabetologia 1997;40(11):1300-6.
1997: Herman W H; Fajans S S; Smith M J; Polonsky K S; Bell G I; Halter J B
Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene.
Diabetes 1997;46(11):1749-54.
1997: Regazzi R; Verchere C B; Halban P A; Polonsky K S
Insulin production: from gene to granule.
Diabetologia 1997;40 Suppl 3():B33-8.
1997: Van Cauter E; Polonsky K S; Scheen A J
Roles of circadian rhythmicity and sleep in human glucose regulation.
Endocrine reviews 1997;18(5):716-38.
1997: Cockburn B N; Ostrega D M; Sturis J; Kubstrup C; Polonsky K S; Bell G I
Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
Diabetes 1997;46(9):1434-9.
1997: Chien E K; Hara M; Rouard M; Yano H; Phillippe M; Polonsky K S; Bell G I
Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats.
Biochemical and biophysical research communications 1997;237(2):476-80.
1997: Cavaghan M K; Ehrmann D A; Byrne M M; Polonsky K S
Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.
The Journal of clinical investigation 1997;100(3):530-7.
1997: Polonsky K S; Byrne M M; Sturis J
Alternative insulin delivery systems: how demanding should the patient be?
Diabetologia 1997;40 Suppl 2():S97-101.
1997: Ehrmann D A; Schneider D J; Sobel B E; Cavaghan M K; Imperial J; Rosenfield R L; Polonsky K S
Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(7):2108-16.
1997: Jones C N; Pei D; Staris P; Polonsky K S; Chen Y D; Reaven G M
Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals.
The Journal of clinical endocrinology and metabolism 1997;82(6):1834-8.
1997: Warren-Perry M G; Manley S E; Ostrega D; Polonsky K; Mussett S; Brown P; Turner R C
A novel point mutation in the insulin gene giving rise to hyperproinsulinemia.
The Journal of clinical endocrinology and metabolism 1997;82(5):1629-31.
1997: Ehrmann D A; Cavaghan M K; Imperial J; Sturis J; Rosenfield R L; Polonsky K S
Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(2):524-30.
1997: Del Sindaco P; Casucci G; Pampanelli S; Polonsky K; Fanelli C; Torlone E; Santeusanio F; Brunetti P; Bolli G B
Late post-prandial hypoglycaemia as the sole presenting feature of secreting pancreatic beta-cell adenoma in a subtotally gastrectomized patient.
European journal of endocrinology / European Federation of Endocrine Societies 1997;136(1):96-9.
1997: Wang X; Zinkel S; Polonsky K; Fuchs E
Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):219-26.
1996: Yamagata K; Oda N; Kaisaki P J; Menzel S; Furuta H; Vaxillaire M; Southam L; Cox R D; Lathrop G M; Boriraj V V; Chen X; Cox N J; Oda Y; Yano H; Le Beau M M; Yamada S; Nishigori H; Takeda J; Fajans S S; Hattersley A T; Iwasaki N; Hansen T; Pedersen O; Polonsky K S; Bell G I
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
Nature 1996;384(6608):455-8.
1996: Sinha M K; Sturis J; Ohannesian J; Magosin S; Stephens T; Heiman M L; Polonsky K S; Caro J F
Ultradian oscillations of leptin secretion in humans.
Biochemical and biophysical research communications 1996;228(3):733-8.
1996: Biston P; Van Cauter E; Ofek G; Linkowski P; Polonsky K S; Degaute J P
Diurnal variations in cardiovascular function and glucose regulation in normotensive humans.
Hypertension 1996;28(5):863-71.
1996: MacDonald M J; Tang J; Polonsky K S
Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats.
Diabetes 1996;45(11):1626-30.
1996: Byrne M M; Sturis J; Menzel S; Yamagata K; Fajans S S; Dronsfield M J; Bain S C; Hattersley A T; Velho G; Froguel P; Bell G I; Polonsky K S
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
Diabetes 1996;45(11):1503-10.
1996: Sreenan S; Sturis J; Pugh W; Burant C F; Polonsky K S
Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone.
The American journal of physiology 1996;271(4 Pt 1):E742-7.
1996: Fajans S S; Bell G I; Bowden D W; Halter J B; Polonsky K S
Maturity onset diabetes of the young (MODY).
Diabetic medicine : a journal of the British Diabetic Association 1996;13(9 Suppl 6):S90-5.
1996: Glaum S R; Hara M; Bindokas V P; Lee C C; Polonsky K S; Bell G I; Miller R J
Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus.
Molecular pharmacology 1996;50(2):230-5.
1996: Gumbiner B; Van Cauter E; Beltz W F; Ditzler T M; Griver K; Polonsky K S; Henry R R
Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: effects of weight reduction.
The Journal of clinical endocrinology and metabolism 1996;81(6):2061-8.
1996: Montgomery T M; Nelson R W; Feldman E C; Robertson K; Polonsky K S
Basal and glucagon-stimulated plasma C-peptide concentrations in healthy dogs, dogs with diabetes mellitus, and dogs with hyperadrenocorticism.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1996;10(3):116-22.
1996: Scheen A J; Sturis J; Polonsky K S; Van Cauter E
Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging.
Diabetologia 1996;39(5):564-72.
1996: Byrne M M; Sturis J; Sobel R J; Polonsky K S
Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function.
The American journal of physiology 1996;270(4 Pt 1):E572-9.
1996: Velho G; Byrne M M; Clément K; Sturis J; Pueyo M E; Blanché H; Vionnet N; Fiet J; Passa P; Robert J J; Polonsky K S; Froguel P
Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation.
Diabetes 1996;45(4):478-87.
1996: Tang J; Pugh W; Polonsky K S; Zhang H
Preservation of insulin secretory responses to P2 purinoceptor agonists in Zucker diabetic fatty rats.
The American journal of physiology 1996;270(3 Pt 1):E504-12.
1996: Tokuyama Y; Fan Z; Furuta H; Makielski J C; Polonsky K S; Bell G I; Yano H
Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
Biochemical and biophysical research communications 1996;220(3):532-8.
1996: Polonsky K S; Sturis J; Bell G I
Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.
The New England journal of medicine 1996;334(12):777-83.
1996: Robbins D C; Andersen L; Bowsher R; Chance R; Dinesen B; Frank B; Gingerich R; Goldstein D; Widemeyer H M; Haffner S; Hales C N; Jarett L; Polonsky K; Porte D; Skyler J; Webb G; Gallagher K
Report of the American Diabetes Association's Task Force on standardization of the insulin assay.
Diabetes 1996;45(2):242-56.
1996: Roe M W; Worley J F; Tokuyama Y; Philipson L H; Sturis J; Tang J; Dukes I D; Bell G I; Polonsky K S
NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity.
The American journal of physiology 1996;270(1 Pt 1):E133-40.
1996: Plat L; Byrne M M; Sturis J; Polonsky K S; Mockel J; Féry F; Van Cauter E
Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans.
The American journal of physiology 1996;270(1 Pt 1):E36-42.
1996: Bell G I; Pilkis S J; Weber I T; Polonsky K S
Glucokinase mutations, insulin secretion, and diabetes mellitus.
Annual review of physiology 1996;58():171-86.
1995: Frank S A; Roland D C; Sturis J; Byrne M M; Refetoff S; Polonsky K S; Van Cauter E
Effects of aging on glucose regulation during wakefulness and sleep.
The American journal of physiology 1995;269(6 Pt 1):E1006-16.
1995: Tokuyama Y; Sturis J; DePaoli A M; Takeda J; Stoffel M; Tang J; Sun X; Polonsky K S; Bell G I
Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.
Diabetes 1995;44(12):1447-57.
1995: O'Rahilly S; Gray H; Humphreys P J; Krook A; Polonsky K S; White A; Gibson S; Taylor K; Carr C
Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function.
The New England journal of medicine 1995;333(21):1386-90.
1995: Sturis J; Pugh W L; Tang J; Polonsky K S
Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat.
The American journal of physiology 1995;269(4 Pt 1):E786-92.
1995: Byrne M M; Sturis J; O'Meara N M; Polonsky K S
Insulin secretion in insulin-resistant women with a history of gestational diabetes.
Metabolism: clinical and experimental 1995;44(8):1067-73.
1995: Stoffel M; Tokuyama Y; Trabb J B; German M S; Tsaar M L; Jan L Y; Polonsky K S; Bell G I
Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
Biochemical and biophysical research communications 1995;212(3):894-9.
1995: Ehrmann D A; Sturis J; Byrne M M; Karrison T; Rosenfield R L; Polonsky K S
Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1995;96(1):520-7.
1995: Polonsky K S
Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research.
Diabetes 1995;44(6):705-17.
1995: Byrne M M; Sturis J; Fajans S S; Ortiz F J; Stoltz A; Stoffel M; Smith M J; Bell G I; Halter J B; Polonsky K S
Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.
Diabetes 1995;44(6):699-704.
1995: Ryan E A; Imes S; Liu D; McManus R; Finegood D T; Polonsky K S; Sturis J
Defects in insulin secretion and action in women with a history of gestational diabetes.
Diabetes 1995;44(5):506-12.
1995: Sturis J; Scheen A J; Leproult R; Polonsky K S; van Cauter E
24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.
The Journal of clinical investigation 1995;95(4):1464-71.
1995: Ostrega D; Polonsky K; Nagi D; Yudkin J; Cox L J; Clark P M; Hales C N
Measurement of proinsulin and intermediates. Validation of immunoassay methods by high-performance liquid chromatography.
Diabetes 1995;44(4):437-40.
1995: O'Meara N M; Sturis J; Herold K C; Ostrega D M; Polonsky K S
Alterations in the patterns of insulin secretion before and after diagnosis of IDDM.
Diabetes care 1995;18(4):568-71.
1995: Byrne M M; Sturis J; Polonsky K S
Insulin secretion and clearance during low-dose graded glucose infusion.
The American journal of physiology 1995;268(1 Pt 1):E21-7.
1994: Van Cauter E V; Polonsky K S; Blackman J D; Roland D; Sturis J; Byrne M M; Scheen A J
Abnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity.
The Journal of clinical endocrinology and metabolism 1994;79(6):1797-805.
1994: O'Meara N M; Cabana V G; Lukens J R; Loharikar B; Forte T M; Polonsky K S; Getz G S
Heparin-induced lipolysis in hypertriglyceridemic subjects results in the formation of atypical HDL particles.
Journal of lipid research 1994;35(12):2178-90.
1994: Iwashima Y; Kondoh-Abiko A; Seino S; Takeda J; Eto M; Polonsky K S; Makino I
Reduced levels of messenger ribonucleic acid for calcium channel, glucose transporter-2, and glucokinase are associated with alterations in insulin secretion in fasted rats.
Endocrinology 1994;135(3):1010-7.
1994: Sturis J; Pugh W L; Tang J; Ostrega D M; Polonsky J S; Polonsky K S
Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat.
The American journal of physiology 1994;267(2 Pt 1):E250-9.
1994: Lewis G F; Steiner G; Polonsky K S; Weller B; Zinman B
A new method for comparing portal and peripheral venous insulin delivery in humans: tolbutamide versus insulin infusion.
The Journal of clinical endocrinology and metabolism 1994;79(1):66-70.
1994: Polonsky K S; Gumbiner B; Ostrega D; Griver K; Tager H; Henry R R
Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM.
Diabetes 1994;43(7):871-7.
1994: Sturis J; Kurland I J; Byrne M M; Mosekilde E; Froguel P; Pilkis S J; Bell G I; Polonsky K S
Compensation in pancreatic beta-cell function in subjects with glucokinase mutations.
Diabetes 1994;43(5):718-23.
1994: Herman W H; Fajans S S; Ortiz F J; Smith M J; Sturis J; Bell G I; Polonsky K S; Halter J B
Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree.
Diabetes 1994;43(1):40-6.
1994: Fajans S S; Bell G I; Bowden D W; Halter J B; Polonsky K S
Maturity-onset diabetes of the young.
Life sciences 1994;55(6):413-22.
1993: Lewis G F; McNally C; Blackman J D; Polonsky K S; Barron W M
Prior feeding alters the response to the 50-g glucose challenge test in pregnancy. The Staub-Traugott effect revisited.
Diabetes care 1993;16(12):1551-6.
1993: Kelley D E; Wing R; Buonocore C; Sturis J; Polonsky K; Fitzsimmons M
Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1993;77(5):1287-93.
1993: Levitt N S; Hirsch L; Rubenstein A H; Polonsky K S
Quantitative evaluation of the effect of low-intensity exercise on insulin secretion in man.
Metabolism: clinical and experimental 1993;42(7):829-33.
1993: O'Meara N M; Sturis J; Van Cauter E; Polonsky K S
Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1993;92(1):262-71.
1993: Jeng C Y; Sheu W H; Jaspan J B; Polonsky K S; Chen Y D; Reaven G M
Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1993;77(1):6-10.
1993: Iwashima Y; Pugh W; Depaoli A M; Takeda J; Seino S; Bell G I; Polonsky K S
Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
Diabetes 1993;42(7):948-55.
1993: O'Meara N M; Sturis J; Blackman J D; Byrne M M; Jaspan J B; Roland D C; Thistlethwaite J R; Polonsky K S
Oscillatory insulin secretion after pancreas transplant.
Diabetes 1993;42(6):855-61.
1993: O'Meara N M; Blackman J D; Ehrmann D A; Barnes R B; Jaspan J B; Rosenfield R L; Polonsky K S
Defects in beta-cell function in functional ovarian hyperandrogenism.
The Journal of clinical endocrinology and metabolism 1993;76(5):1241-7.
1993: Sturis J; O'Meara N M; Shapiro E T; Blackman J D; Tillil H; Polonsky K S; Van Cauter E
Differential effects of glucose stimulation upon rapid pulses and ultradian oscillations of insulin secretion.
The Journal of clinical endocrinology and metabolism 1993;76(4):895-901.
1993: O'Meara N M; Sturis J; Blackman J D; Roland D C; Van Cauter E; Polonsky K S
Analytical problems in detecting rapid insulin secretory pulses in normal humans.
The American journal of physiology 1993;264(2 Pt 1):E231-8.
1993: O'Meara N M; Blackman J D; Sturis J; Polonsky K S
Alterations in the kinetics of C-peptide and insulin secretion in hyperthyroidism.
The Journal of clinical endocrinology and metabolism 1993;76(1):79-84.
1993: Reaven G M; Chen Y D; Hollenbeck C B; Sheu W H; Ostrega D; Polonsky K S
Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance.
The Journal of clinical endocrinology and metabolism 1993;76(1):44-8.
1992: Blackman J D; Polonsky K S; Jaspan J B; Sturis J; Van Cauter E; Thistlethwaite J R
Insulin secretory profiles and C-peptide clearance kinetics at 6 months and 2 years after kidney-pancreas transplantation.
Diabetes 1992;41(10):1346-54.
1992: O'Meara N M; Lewis G F; Cabana V G; Iverius P H; Getz G S; Polonsky K S
Role of basal triglyceride and high density lipoprotein in determination of postprandial lipid and lipoprotein responses.
The Journal of clinical endocrinology and metabolism 1992;75(2):465-71.
1992: Sturis J; Polonsky K S; Shapiro E T; Blackman J D; O'Meara N M; van Cauter E
Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in type 2 (non-insulin-dependent) diabetic patients.
Diabetologia 1992;35(7):681-9.
1992: Yano H; Kitano N; Morimoto M; Polonsky K S; Imura H; Seino Y
A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).
The Journal of clinical investigation 1992;89(6):1902-7.
1992: Van Cauter E; Shapiro E T; Tillil H; Polonsky K S
Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm.
The American journal of physiology 1992;262(4 Pt 1):E467-75.
1992: Polonsky K S
A practical approach to fasting hypoglycemia.
The New England journal of medicine 1992;326(15):1020-1.
1992: Blackman J D; Towle V L; Sturis J; Lewis G F; Spire J P; Polonsky K S
Hypoglycemic thresholds for cognitive dysfunction in IDDM.
Diabetes 1992;41(3):392-9.
1992: Van Cauter E; Mestrez F; Sturis J; Polonsky K S
Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance.
Diabetes 1992;41(3):368-77.
1991: Shapiro E T; Strasser S; Polonsky K S; Alejandro R; Mintz D H
Persistence of oscillatory insulin secretion in denervated islet cell autografts.
Transplantation 1991;52(3):574-6.
1991: Van Cauter E; Blackman J D; Roland D; Spire J P; Refetoff S; Polonsky K S
Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.
The Journal of clinical investigation 1991;88(3):934-42.
1991: Given B D; Ostrega D M; Polonsky K S; Baldwin D; Kelley R I; Rubenstein A H
Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography.
Diabetes care 1991;14(7):544-7.
1991: Sturis J; Polonsky K S; Mosekilde E; Van Cauter E
Computer model for mechanisms underlying ultradian oscillations of insulin and glucose.
The American journal of physiology 1991;260(5 Pt 1):E801-9.
1991: Lewis G F; O'Meara N M; Cabana V G; Blackman J D; Pugh W L; Druetzler A F; Lukens J R; Getz G S; Polonsky K S
Postprandial triglyceride response in type 1 (insulin-dependent) diabetes mellitus is not altered by short-term deterioration in glycaemic control or level of postprandial insulin replacement.
Diabetologia 1991;34(4):253-9.
1991: Lewis G F; O'Meara N M; Soltys P A; Blackman J D; Iverius P H; Pugh W L; Getz G S; Polonsky K S
Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities.
The Journal of clinical endocrinology and metabolism 1991;72(4):934-44.
1991: Herold K C; Polonsky K S
Does tight glucose control enhance brain sensitivity to low glucose?
Diabetes care 1991;14(2):141-3.
1991: Sturis J; Van Cauter E; Blackman J D; Polonsky K S
Entrainment of pulsatile insulin secretion by oscillatory glucose infusion.
The Journal of clinical investigation 1991;87(2):439-45.
1991: Shapiro E T; Polonsky K S; Copinschi G; Bosson D; Tillil H; Blackman J; Lewis G; Van Cauter E
Nocturnal elevation of glucose levels during fasting in noninsulin-dependent diabetes.
The Journal of clinical endocrinology and metabolism 1991;72(2):444-54.
1991: Cooper M D; Chen C T; Metz J; Polonsky K; Levy J
Effects of insulin mediated plasma glucose changes on brain function. Implications from experimental and derived data.
Acta radiologica. Supplementum 1991;376():161-2.
1990: Strack T R; Greenberg G R; Polonsky K S; Albisser A M
The effect of a time delay on the characteristics of the canine glucoregulatory system.
Metabolism: clinical and experimental 1990;39(12):1219-24.
1990: Tillil H; Frank B H; Pekar A H; Broelsch C; Rubenstein A H; Polonsky K S
Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites.
Endocrinology 1990;127(5):2418-22.
1990: Lewis G F; O'Meara N M; Soltys P A; Blackman J D; Iverius P H; Druetzler A F; Getz G S; Polonsky K S
Postprandial lipoprotein metabolism in normal and obese subjects: comparison after the vitamin A fat-loading test.
The Journal of clinical endocrinology and metabolism 1990;71(4):1041-50.
1990: Wojcikowski C; Blackman J; Ostrega D; Lewis G; Galloway J; Rubenstein A H; Polonsky K S
Lack of effect of high-dose biosynthetic human C-peptide on pancreatic hormone release in normal subjects.
Metabolism: clinical and experimental 1990;39(8):827-32.
1990: O'Meara N M; Shapiro E T; Van Cauter E; Polonsky K S
Effect of glyburide on beta cell responsiveness to glucose in non-insulin-dependent diabetes mellitus.
The American journal of medicine 1990;89(2A):11S-16S; discussion 51S-53S.
1990: Beebe C A; Van Cauter E; Shapiro E T; Tillil H; Lyons R; Rubenstein A H; Polonsky K S
Effect of temporal distribution of calories on diurnal patterns of glucose levels and insulin secretion in NIDDM.
Diabetes care 1990;13(7):748-55.
1990: Blackman J D; Towle V L; Lewis G F; Spire J P; Polonsky K S
Hypoglycemic thresholds for cognitive dysfunction in humans.
Diabetes 1990;39(7):828-35.
1990: Gumbiner B; Polonsky K S; Beltz W F; Griver K; Wallace P; Brechtel G; Henry R R
Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1990;70(6):1594-602.
1990: Shapiro E T; Bell G I; Polonsky K S; Rubenstein A H; Kew M C; Tager H S
Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II.
The Journal of clinical investigation 1990;85(5):1672-9.
1990: Shapiro E T; Cooper M; Chen C T; Given B D; Polonsky K S
Change in hexose distribution volume and fractional utilization of [18F]-2-deoxy-2-fluoro-D-glucose in brain during acute hypoglycemia in humans.
Diabetes 1990;39(2):175-80.
1990: Kryshak E J; Butler P C; Marsh C; Miller A; Barr D; Polonsky K; Perkins J D; Rizza R A
Pattern of postprandial carbohydrate metabolism and effects of portal and peripheral insulin delivery.
Diabetes 1990;39(2):142-8.
1989: Gumbiner B; Polonsky K S; Beltz W F; Wallace P; Brechtel G; Fink R I
Effects of aging on insulin secretion.
Diabetes 1989;38(12):1549-56.
1989: Shapiro E T; Van Cauter E; Tillil H; Given B D; Hirsch L; Beebe C; Rubenstein A H; Polonsky K S
Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1989;69(3):571-6.
1988: Kremser C B; Levitt N S; Borow K M; Jaspan J B; Lindbloom C; Polonsky K S; Leff A R
Oxygen uptake kinetics during exercise in diabetic neuropathy.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(6):2665-71.
1988: Shapiro E T; Tillil H; Rubenstein A H; Polonsky K S
Peripheral insulin parallels changes in insulin secretion more closely than C-peptide after bolus intravenous glucose administration.
The Journal of clinical endocrinology and metabolism 1988;67(5):1094-9.
1988: Tillil H; Shapiro E T; Rubenstein A H; Galloway J A; Polonsky K S
Reduction of insulin clearance during hyperglycemic clamp. Dose-response study in normal humans.
Diabetes 1988;37(10):1351-7.
1988: Tillil H; Shapiro E T; Given B D; Rue P; Rubenstein A H; Galloway J A; Polonsky K S
Reevaluation of urine C-peptide as measure of insulin secretion.
Diabetes 1988;37(9):1195-201.
1988: Shapiro E T; Tillil H; Polonsky K S; Fang V S; Rubenstein A H; Van Cauter E
Oscillations in insulin secretion during constant glucose infusion in normal man: relationship to changes in plasma glucose.
The Journal of clinical endocrinology and metabolism 1988;67(2):307-14.
1988: Alejandro R; Latif Z; Polonsky K S; Shienvold F L; Civantos F; Mint D H
Natural history of multiple intrahepatic canine islet allografts during and following administration of cyclosporine.
Transplantation 1988;45(6):1036-44.
1988: Polonsky K S; Given B D; Hirsch L J; Tillil H; Shapiro E T; Beebe C; Frank B H; Galloway J A; Van Cauter E
Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.
The New England journal of medicine 1988;318(19):1231-9.
1988: Tillil H; Shapiro E T; Miller M A; Karrison T; Frank B H; Galloway J A; Rubenstein A H; Polonsky K S
Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans.
The American journal of physiology 1988;254(3 Pt 1):E349-57.
1988: Polonsky K S; Given B D; Van Cauter E
Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.
The Journal of clinical investigation 1988;81(2):442-8.
1988: Polonsky K S; Given B D; Hirsch L; Shapiro E T; Tillil H; Beebe C; Galloway J A; Frank B H; Karrison T; Van Cauter E
Quantitative study of insulin secretion and clearance in normal and obese subjects.
The Journal of clinical investigation 1988;81(2):435-41.
1987: Shapiro E T; Tillil H; Miller M A; Frank B H; Galloway J A; Rubenstein A H; Polonsky K S
Insulin secretion and clearance. Comparison after oral and intravenous glucose.
Diabetes 1987;36(12):1365-71.
1987: Vølund A; Polonsky K S; Bergman R N
Calculated pattern of intraportal insulin appearance without independent assessment of C-peptide kinetics.
Diabetes 1987;36(10):1195-202.
1987: Cohen R M; Licinio J; Polonsky K S; Galloway J A; Frank B H; Cherrington A D; Rubenstein A H
The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes.
The Journal of clinical endocrinology and metabolism 1987;64(3):476-81.
1987: Nanjo K; Miyano M; Kondo M; Sanke T; Nishimura S; Miyamura K; Inouye K; Given B D; Chan S J; Polonsky K S
Insulin Wakayama: familial mutant insulin syndrome in Japan.
Diabetologia 1987;30(2):87-92.
1986: Cohen R M; Given B D; Licinio-Paixao J; Provow S A; Rue P A; Frank B H; Root M A; Polonsky K S; Tager H S; Rubenstein A H
Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia.
Metabolism: clinical and experimental 1986;35(12):1137-46.
1986: Alejandro R; Cutfield R G; Shienvold F L; Polonsky K S; Noel J; Olson L; Dillberger J; Miller J; Mintz D H
Natural history of intrahepatic canine islet cell autografts.
The Journal of clinical investigation 1986;78(5):1339-48.
1986: Stagner J; Samols E; Polonsky K; Pugh W
Lack of direct inhibition of insulin secretion by exogenous insulin in the canine pancreas.
The Journal of clinical investigation 1986;78(5):1193-8.
1986: Licinio-Paixao J; Polonsky K S; Given B D; Pugh W; Ostrega D; Frank B F; Rubenstein A H
Ingestion of a mixed meal does not affect the metabolic clearance rate of biosynthetic human C-peptide.
The Journal of clinical endocrinology and metabolism 1986;63(2):401-3.
1986: Jaspan J B; Lever E; Polonsky K S; Van Cauter E
In vivo pulsatility of pancreatic islet peptides.
The American journal of physiology 1986;251(2 Pt 1):E215-26.
1986: Morishima T; Pye S; Polonsky K; Radziuk J
The measurement and validation of the nonsteady-state rates of C-peptide appearance in the dog.
Diabetologia 1986;29(7):440-6.
1986: Polonsky K S; Given B D; Pugh W; Licinio-Paixao J; Thompson J E; Karrison T; Rubenstein A H
Calculation of the systemic delivery rate of insulin in normal man.
The Journal of clinical endocrinology and metabolism 1986;63(1):113-8.
1986: Shoelson S E; Polonsky K S; Nakabayashi T; Jaspan J B; Tager H S
Circulating forms of somatostatinlike immunoreactivity in human plasma.
The American journal of physiology 1986;250(4 Pt 1):E428-34.
1986: Polonsky K; Frank B; Pugh W; Addis A; Karrison T; Meier P; Tager H; Rubenstein A
The limitations to and valid use of C-peptide as a marker of the secretion of insulin.
Diabetes 1986;35(4):379-86.
1986: Polonsky K S; Licinio-Paixao J; Given B D; Pugh W; Rue P; Galloway J; Karrison T; Frank B
Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.
The Journal of clinical investigation 1986;77(1):98-105.
1986: Polonsky K S; Rubenstein A H
Current approaches to measurement of insulin secretion.
Diabetes/metabolism reviews 1986;2(3-4):315-29.
1986: Nanjo K; Sanke T; Kondo M; Nishimura S; Miyano M; Linuma J; Miyamura K; Inouye K; Given B D; Polonsky K S
Mutant insulin syndrome: identification of two families with [LeuA3]insulin and determination of its biological activity.
Transactions of the Association of American Physicians 1986;99():132-42.
1985: Herold K C; Polonsky K S; Cohen R M; Levy J; Douglas F
Variable deterioration in cortical function during insulin-induced hypoglycemia.
Diabetes 1985;34(7):677-85.
1985: Cutfield R G; Polonsky K; Olson L; Kyriakides G; Miller J; Mintz D H
Long-term follow-up of canine segmental pancreatic autografts.
Diabetes 1985;34(2):174-8.
1984: Polonsky K S; Pugh W; Jaspan J B; Cohen D M; Karrison T; Tager H S; Rubenstein A H
C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog.
The Journal of clinical investigation 1984;74(5):1821-9.
1984: Polonsky K S; Herold K C; Gilden J L; Bergenstal R M; Fang V S; Moossa A R; Jaspan J B
Glucose counterregulation in patients after pancreatectomy. Comparison with other clinical forms of diabetes.
Diabetes 1984;33(11):1112-9.
1984: Cohen D M; Jaspan J B; Polonsky K S; Lever E G; Moossa A R
Pancreatic hormone profiles and metabolism posthepatectomy in the dog. Evidence for a hepatotrophic role of insulin, glucagon, and pancreatic polypeptide.
Gastroenterology 1984;87(3):679-87.
1984: Revers R R; Henry R; Schmeiser L; Kolterman O; Cohen R; Bergenstal R; Polonsky K; Jaspan J; Rubenstein A; Frank B
The effects of biosynthetic human proinsulin on carbohydrate metabolism.
Diabetes 1984;33(8):762-70.
1984: Bergenstal R M; Cohen R M; Lever E; Polonsky K; Jaspan J; Blix P M; Revers R; Olefsky J M; Kolterman O; Steiner K
The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes.
The Journal of clinical endocrinology and metabolism 1984;58(6):973-9.
1984: Polonsky K S; Rubenstein A H
C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations.
Diabetes 1984;33(5):486-94.
1984: Haneda M; Polonsky K S; Bergenstal R M; Jaspan J B; Shoelson S E; Blix P M; Chan S J; Kwok S C; Wishner W B; Zeidler A
Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome.
The New England journal of medicine 1984;310(20):1288-94.
1984: Shoelson S E; Polonsky K S; Zeidler A; Rubenstein A H; Tager H S
Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model.
The Journal of clinical investigation 1984;73(5):1351-8.
1983: Polonsky K; Jaspan J; Pugh W; Cohen D; Schneider M; Schwartz T; Moossa A R; Tager H; Rubenstein A H
Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction.
The Journal of clinical investigation 1983;72(3):1114-23.
1983: Hagopian W; Lever E G; Cohen D; Emmanouel D; Polonsky K S; Pugh W; Moossa A; Jaspan J B
Predominance of renal and absence of hepatic metabolism of pancreatic polypeptide in the dog.
The American journal of physiology 1983;245(2):E171-7.
1983: Bergenstal R M; Polonsky K S; Pons G; Jaspan J B; Rubenstein A H
Lack of glucagon response to hypoglycemia in type I diabetics after long-term optimal therapy with a continuous subcutaneous insulin infusion pump.
Diabetes 1983;32(5):398-402.
1983: Polonsky K S; Shoelson S E; Docherty H M
Plasma somatostatin 28 increases in response to feeding in man.
The Journal of clinical investigation 1983;71(5):1514-8.
1983: Polonsky K; Jaspan J; Emmanouel D; Holmes K; Moossa A R
Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism.
Acta endocrinologica 1983;102(3):420-7.
1983: Soybel D; Jaspan J; Polonsky K; Goldberg I; Rayfield E; Tager H
Differential immunoreactivity of plasma glucagon components in man: studies with different glucagon antibodies.
The Journal of clinical endocrinology and metabolism 1983;56(3):612-8.
1983: Judzewitsch R G; Jaspan J B; Polonsky K S; Weinberg C R; Halter J B; Halar E; Pfeifer M A; Vukadinovic C; Bernstein L; Schneider M; Liang K Y; Gabbay K H; Rubenstein A H; Porte D
Aldose reductase inhibition improves nerve conduction velocity in diabetic patients.
The New England journal of medicine 1983;308(3):119-25.
1983: Shoelson S E; Peters A L; Nakabayashi T; Polonsky K S
Responses of somatostatin components to oral glucose in human plasma.
Transactions of the Association of American Physicians 1983;96():113-21.
1982: Polonsky K; Jaspan J; Berelowitz M; Pugh W; Moossa A; Ling N
The in vivo metabolism of somatostatin 28: possible relationship between diminished metabolism and enhanced biological action.
Endocrinology 1982;111(5):1698-703.
1982: Polonsky K; Bergenstal R; Pons G; Schneider M; Jaspan J; Rubenstein A
Relation of counterregulatory responses to hypoglycemia in type I diabetics.
The New England journal of medicine 1982;307(18):1106-12.
1982: Shoelson S; Polonsky K; Docherty H; Jaspan J; Rubenstein A
Evidence for the presence of somatostatin 28 in plasma.
Diabetes 1982;31(5 Pt 1):474-7.
1982: Bonnevie-Nielsen V; Polonsky K S; Jaspan J J; Rubenstein A H; Schwartz T W; Tager H S
Surface receptors for pancreatic hormones in dog and rat hepatocytes: qualitative and quantitative differences in hormone-target cell interactions.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2167-71.
1982: Jaspan J; Polonsky K
Glucose ingestion in dogs alters the hepatic extraction of insulin. In vivo evidence for a relationship between biologic action and extraction of insulin.
The Journal of clinical investigation 1982;69(3):516-25.
1981: Polonsky K S; Jaspan J B; Berelowitz M; Emmanouel D S; Dhorajiwala J
Hepatic and renal metabolism of somatostatin-like immunoreactivity. Simultaneous assessment in the dog.
The Journal of clinical investigation 1981;68(5):1149-57.
1981: Jaspan J B; Polonsky K S; Röjdmark S; Ishida T; Field J B; Rubenstein A H
Hepatic extraction of plasma immunoreactive glucagon components. Predilection for 3500-dalton glucagon metabolism by the liver.
Diabetes 1981;30(9):767-72.
1981: Polonsky K; Jaspan J; Pugh W; Dhorajiwala J; Abraham M; Blix P; Moossa A R
Insulin and glucagon breakthrough of somatostatin suppression: importance of portal vein hormone measurements.
Diabetes 1981;30(8):664-9.
1981: Stacpoole P W; Jaspan J; Kasselberg A G; Halter S A; Polonsky K; Gluck F W; Liljenquist J E; Rabin D
A familial glucagonoma syndrome: genetic, clinical and biochemical features.
The American journal of medicine 1981;70(5):1017-26.
1981: Jaspan J B; Polonsky K S; Lewis M; Pensler J; Pugh W; Moossa A R; Rubenstein A H
Hepatic metabolism of glucagon in the dog: contribution of the liver to overall metabolic disposal of glucagon.
The American journal of physiology 1981;240(3):E233-44.
1979: Jaspan J; Polonsky K; Lewis M; Moossa A R
Reduction in portal vein blood flow by somatostatin.
Diabetes 1979;28(10):888-92.

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