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Joseph Bertino

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Co-Publications
Name
67
Banerjee, Debabrata
24
Gorlick, Richard
17
Zhao, SC
14
Tong, William
11
Ercikan-Abali, EA
11
Kemeny, Nancy
11
Mineishi, S
10
Takebe, Naoko
10
Dicker, Adam
9
Mishra, Prasun
9
Trippett, Tanya
9
Mayer-Kuckuk, Philipp
9
Portlock, Carol
9
Fan, J
9
Danenberg, Peter

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Publications

TOP 3
Mishra Prasun J; Menon Lata G; Mishra Pravin J; Mayer-Kuckuk Philipp; Bertino Joseph R; Banerjee Debabrata
Translational modulation of proteins expressed from bicistronic vectors.
Levitt M J; Gharibo M; Strair R; Schaar D; Rubin A; Bertino J R
Accelerated R-COP: a pilot study for the treatment of advanced low grade lymphomas that has a high complete response rate.
Humeniuk Rita; Mishra Prasun J; Bertino Joseph R; Banerjee Debabrata
Molecular targets for epigenetic therapy of cancer.

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All Publications

2009: Mishra Prasun J; Menon Lata G; Mishra Pravin J; Mayer-Kuckuk Philipp; Bertino Joseph R; Banerjee Debabrata
Translational modulation of proteins expressed from bicistronic vectors.
Molecular imaging : official journal of the Society for Molecular Imaging 2009;8(6):305-18.
2009: Levitt M J; Gharibo M; Strair R; Schaar D; Rubin A; Bertino J R
Accelerated R-COP: a pilot study for the treatment of advanced low grade lymphomas that has a high complete response rate.
Journal of chemotherapy (Florence, Italy) 2009;21(4):434-8.
2009: Humeniuk Rita; Mishra Prasun J; Bertino Joseph R; Banerjee Debabrata
Molecular targets for epigenetic therapy of cancer.
Current pharmaceutical biotechnology 2009;10(2):161-5.
2009: Mishra Prasun J; Song Bo; Mishra Pravin J; Wang Yuan; Humeniuk Rita; Banerjee Debabrata; Merlino Glenn; Ju Jingfang; Bertino Joseph R
MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism.
PloS one 2009;4(12):e8445.
2009: Budak-Alpdogan Tulin; Bertino Joseph R
Chemoprotection by transfer of resistance genes.
Methods in molecular biology (Clifton, N.J.) 2009;542():661-704.
2008: Bertino Joseph R
Transfer of drug resistance genes into hematopoietic stem cells for marrow protection.
The oncologist 2008;13(10):1036-42.
2008: Mishra Prasun J; Mishra Pravin J; Banerjee Debabrata; Bertino Joseph R
MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: Introducing microRNA pharmacogenomics.
Cell cycle (Georgetown, Tex.) 2008;7(7):853-8.
2007: Bertino Joseph R; Banerjee Debabrata; Mishra Prasun J
Pharmacogenomics of microRNA: a miRSNP towards individualized therapy.
Pharmacogenomics 2007;8(12):1625-7.
2007: Humeniuk R; Menon L G; Mishra P J; Saydam G; Longo-Sorbello G S A; Elisseyeff Y; Lewis L D; Aracil M; Jimeno J; Bertino J R; Banerjee D
Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(12):2399-405.
2007: Moskowitz C H; Hamlin P A; Gabrilove J; Bertino J R; Portlock C S; Straus D J; Gencarelli A N; Nimer S D; Zelenetz A D
Maintaining the dose intensity of ICE chemotherapy with a thrombopoietic agent, PEG-rHuMGDF, may confer a survival advantage in relapsed and refractory aggressive non-Hodgkin lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(11):1842-50.
2007: Mishra Prasun J; Humeniuk Rita; Mishra Pravin J; Longo-Sorbello Giuseppe S A; Banerjee Debabrata; Bertino Joseph R
A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13513-8.
2007: Longo-Sorbello Giuseppe S A; Chen Bobin; Budak-Alpdogan Tulin; Bertino Joseph R
Role of pemetrexed in non-small cell lung cancer.
Cancer investigation 2007;25(1):59-66.
2006: Mayer-Kuckuk Philipp; Doubrovin Mikhail; Bidaut Luc; Budak-Alpdogan Tulin; Cai Shangde; Hubbard Vanessa; Alpdogan Onder; van den Brink Marcel; Bertino Joseph R; Blasberg Ronald G; Banerjee Debabrata; Gelovani Juri
Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cells.
Cell transplantation 2006;15(1):75-82.
2005: Budak-Alpdogan Tulin; Banerjee Debabrata; Bertino Joseph R
Hematopoietic stem cell gene therapy with drug resistance genes: an update.
Cancer gene therapy 2005;12(11):849-63.
2005: Mayer-Kuckuk Philipp; Gade Terence P F; Buchanan Ian M; Doubrovin Mikhail; Ageyeva Ludmilla; Bertino Joseph R; Boskey Adele L; Blasberg Ronald G; Koutcher Jason A; Banerjee Debabrata
High-resolution imaging of bone precursor cells within the intact bone marrow cavity of living mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(1):33-41.
2005: Skacel Nancy; Menon Lata G; Mishra Prasunkumar J; Peters Rowayda; Banerjee Debabrata; Bertino Joseph R; Abali Emine Ercikan
Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.
The Journal of biological chemistry 2005;280(24):22721-31.
2004: Capiaux Gina M; Budak-Alpdogan Tulin; Alpdogan Onder; Bornmann William; Takebe Naoko; Banerjee Debabrata; Maley Frank; Bertino Joseph R
Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene.
Cancer gene therapy 2004;11(12):767-73.
2004: Portlock C S; Qin J; Schaindlin P; Roistacher N; Myers J; Filippa D; Louie D; Zelenetz A D; O'Brien J P; Moskowitz C; Norton L; Yahalom J; Straus D J; Bertino J R
The NHL-15 protocol for aggressive non-Hodgkin's lymphomas: a sequential dose-dense, dose-intense regimen of doxorubicin, vincristine and high-dose cyclophosphamide.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(10):1495-503.
2004: Budak-Alpdogan Tulin; Alpdogan Onder; Banerjee Debabrata; Wang Eunice; Moore Malcolm A S; Bertino Joseph R
Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(3):574-84.
2004: Magro Pellegrino G; Russo Angelo J; Li Wei-Wei; Banerjee Debabrata; Bertino Joseph R
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
Cancer research 2004;64(12):4338-45.
2004: Mayer-Kuckuk Philipp; Menon Lata G; Blasberg Ronald G; Bertino Joseph R; Banerjee Debabrata
Role of reporter gene imaging in molecular and cellular biology.
Biological chemistry 2004;385(5):353-61.
2004: Iwamoto Marian; Banerjee Debabrata; Menon Lata G; Jurkiewicz Anna; Rao Pulivarthi H; Kemeny Nancy E; Fong Yuman; Jhanwar Suresh C; Gorlick Richard; Bertino Joseph R
Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification.
Cancer biology & therapy 2004;3(4):395-9.
2004: Li Weiwei; Su Dan; Mizobuchi Hiroo; Martin Daniel S; Gu Bin; Gorlick Richard; Cole Peter; Bertino Joseph R
Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.
Oncology research 2004;14(7-8):373-9.
2003: Levy Adam S; Sather Harland N; Steinherz Peter G; Sowers Rebecca; La Mei; Moscow Jeffrey A; Gaynon Paul S; Uckun Fatih M; Bertino Joseph R; Gorlick Richard;
Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2003;25(9):688-95.
2003: Mayer-Kuckuk Philipp; Doubrovin Mikhail; Gusani Niraj J; Gade Terence; Balatoni Julius; Akhurst Tim; Finn Ronald; Fong Yuman; Koutcher Jason A; Larson Steven; Blasberg Ronald; Tjuvajev Juri Gelovani; Bertino Joseph R; Banerjee Debabrata
Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats.
European journal of nuclear medicine and molecular imaging 2003;30(9):1281-91.
2003: Sowers Rebecca; Toguchida Junya; Qin Jing; Meyers Paul A; Healey John H; Huvos Andrew; Banerjee Debabrata; Bertino Joseph R; Gorlick Richard
mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.
Molecular cancer therapeutics 2003;2(6):535-41.
2003: Capiaux Gina M; Budak-Alpdogan Tulin; Takebe Naoko; Mayer-Kuckuk Philipp; Banerjee Debabrata; Maley Frank; Bertino Joseph R
Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil.
Human gene therapy 2003;14(5):435-46.
2003: Yang Rui; Sowers Rebecca; Mazza BethAnne; Healey John H; Huvos Andrew; Grier Holcombe; Bernstein Mark; Beardsley G Peter; Krailo Mark D; Devidas Meenakshi; Bertino Joseph R; Meyers Paul A; Gorlick Richard
Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):837-44.
2002: Li WeiWei; Bertino Joseph R
Fas-mediated signaling enhances sensitivity of human soft tissue sarcoma cells to anticancer drugs by activation of p38 kinase.
Molecular cancer therapeutics 2002;1(14):1343-8.
2002: Takahashi Naoto; Li WeiWei; Banerjee Debabrata; Guan Yongbiao; Wada-Takahashi Yasuko; Brennan Murray F; Chou Ting-Chao; Scotto Kathleen W; Bertino Joseph R
Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo.
Cancer research 2002;62(23):6909-15.
2002: Wisniewski David; Lambek Caryl L; Liu Chongyuan; Strife Annabel; Veach Darren R; Nagar Bhushan; Young Matthew A; Schindler Thomas; Bornmann William G; Bertino Joseph R; Kuriyan John; Clarkson Bayard
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases.
Cancer research 2002;62(15):4244-55.
2002: Banerjee Debabrata; Mayer-Kuckuk Philipp; Capiaux Gina; Budak-Alpdogan Tulin; Gorlick Richard; Bertino Joseph R
Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase.
Biochimica et biophysica acta 2002;1587(2-3):164-73.
2002: Mayer-Kuckuk Philipp; Banerjee Debabrata; Kemeny Nancy; Fong Yuman; Bertino Joseph R
Molecular therapies for colorectal cancer metastatic to the liver.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(5 Pt 1):492-500.
2002: Banerjee Debabrata; Bertino Joseph R
Myeloprotection with drug-resistance genes.
The lancet oncology 2002;3(3):154-8.
2002: Takebe Naoko; Xu Li-Cheng; MacKenzie Karen L; Bertino Joseph R; Moore Malcolm A S
Methotrexate selection of long-term culture initiating cells following transduction of CD34(+) cells with a retrovirus containing a mutated human dihydrofolate reductase gene.
Cancer gene therapy 2002;9(3):308-20.
2002: García-Castellano José M; Villanueva Alberto; Healey John H; Sowers Rebecca; Cordon-Cardo Carlos; Huvos Andrew; Bertino Joseph R; Meyers Paul; Gorlick Richard
Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(3):782-7.
2002: Mayer-Kuckuk Philipp; Banerjee Debabrata; Malhotra Sundeep; Doubrovin Mikhail; Iwamoto Marian; Akhurst Tim; Balatoni Julius; Bornmann William; Finn Ronald; Larson Steven; Fong Yuman; Gelovani Tjuvajev Juri; Blasberg Ronald; Bertino Joseph R
Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3400-5.
2001: Takebe N; Zhao S C; Ural A U; Johnson M R; Banerjee D; Diasio R B; Bertino J R
Retroviral transduction of human dihydropyrimidine dehydrogenase cDNA confers resistance to 5-fluorouracil in murine hematopoietic progenitor cells and human CD34+-enriched peripheral blood progenitor cells.
Cancer gene therapy 2001;8(12):966-73.
2001: Takahashi N; Li W W; Banerjee D; Scotto K W; Bertino J R
Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(10):3251-7.
2001: Li W W; Takahashi N; Jhanwar S; Cordon-Cardo C; Elisseyeff Y; Jimeno J; Faircloth G; Bertino J R
Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2908-11.
2001: Sapse A M; Capiaux G M; Bertino J R
Examination of the reduced affinity of the thymidylate synthase G52S mutation for FdUMP by ab initio and semi-empirical studies.
Molecular medicine (Cambridge, Mass.) 2001;7(3):200-4.
2001: Li W; Fan J; Bertino J R
Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity.
Cancer research 2001;61(6):2579-82.
2001: Trippett T M; Garcia S; Manova K; Mody R; Cohen-Gould L; Flintoff W; Bertino J R
Localization of a human reduced folate carrier protein in the mitochondrial as well as the cell membrane of leukemia cells.
Cancer research 2001;61(5):1941-7.
2001: Longo-Sorbello G S; Bertino J R
Current understanding of methotrexate pharmacology and efficacy in acute leukemias. Use of newer antifolates in clinical trials.
Haematologica 2001;86(2):121-7.
2001: Moskowitz C H; Nimer S D; Zelenetz A D; Trippett T; Hedrick E E; Filippa D A; Louie D; Gonzales M; Walits J; Coady-Lyons N; Qin J; Frank R; Bertino J R; Goy A; Noy A; O'Brien J P; Straus D; Portlock C S; Yahalom J
A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model.
Blood 2001;97(3):616-23.
2001: Takebe N; Zhao S C; Adhikari D; Mineishi S; Sadelain M; Hilton J; Colvin M; Banerjee D; Bertino J R
Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(1):88-96.
2001: Longo G S; Izzo J; Gorlick R; Banerjee D; Jhanwar S C; Bertino J R
Characterization and drug sensitivity of four newly established colon adenocarcinoma cell lines to antifolate inhibitors of thymidylate synthase.
Oncology research 2001;12(8):309-14.
2000: Martin D S; Bertino J R; Koutcher J A
ATP depletion + pyrimidine depletion can markedly enhance cancer therapy: fresh insight for a new approach.
Cancer research 2000;60(24):6776-83.
2000: Adhikari D; Feroz F; Liefshitz A; Barakat R R; Bertino J R; Banerjee D
Pretreatment of endometrial carcinoma cell lines with butyrate results in upregulation of Bax and correlates with potentiation of radiation induced cell kill.
In vivo (Athens, Greece) 2000;14(5):603-9.
2000: Levy A S; Meyers P; Kellick M; Gorlick R; Tong W; Bertino J R
Acute stroke-like encephalopathy associated with high-dose methotrexate impurities.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2000;22(4):360-2.
2000: Takebe N; Nakahara S; Zhao S C; Adhikari D; Ural A U; Iwamoto M; Banerjee D; Bertino J R
Comparison of methotrexate resistance conferred by a mutated dihydrofolate reductase (DHFR) cDNA in two different retroviral vectors.
Cancer gene therapy 2000;7(6):910-9.
2000: Banerjee D; Gorlick R; Liefshitz A; Danenberg K; Danenberg P C; Danenberg P V; Klimstra D; Jhanwar S; Cordon-Cardo C; Fong Y; Kemeny N; Bertino J R
Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase.
Cancer research 2000;60(9):2365-7.
2000: Ural A U; Takebe N; Adhikari D; Ercikan-Abali E; Banerjee D; Barakat R; Bertino J R
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
Gynecologic oncology 2000;76(3):305-10.
1999: Kemeny N; Huang Y; Cohen A M; Shi W; Conti J A; Brennan M F; Bertino J R; Turnbull A D; Sullivan D; Stockman J; Blumgart L H; Fong Y
Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer.
The New England journal of medicine 1999;341(27):2039-48.
1999: Gorlick R; Bertino J R
Drug resistance in colon cancer.
Seminars in oncology 1999;26(6):606-11.
1999: Moskowitz C H; Bertino J R; Glassman J R; Hedrick E E; Hunte S; Coady-Lyons N; Agus D B; Goy A; Jurcic J; Noy A; O'Brien J; Portlock C S; Straus D S; Childs B; Frank R; Yahalom J; Filippa D; Louie D; Nimer S D; Zelenetz A D
Ifosfamide, carboplatin, and etoposide: a highly effective cytoreduction and peripheral-blood progenitor-cell mobilization regimen for transplant-eligible patients with non-Hodgkin's lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(12):3776-85.
1999: Fan J; Bertino J R
Modulation of cisplatinum cytotoxicity by p53: effect of p53-mediated apoptosis and DNA repair.
Molecular pharmacology 1999;56(5):966-72.
1999: Sauerbrey A; McPherson J P; Zhao S C; Banerjee D; Bertino J R
Expression of a novel double-mutant dihydrofolate reductase-cytidine deaminase fusion gene confers resistance to both methotrexate and cytosine arabinoside.
Human gene therapy 1999;10(15):2495-504.
1999: Kooby D A; Carew J F; Halterman M W; Mack J E; Bertino J R; Blumgart L H; Federoff H J; Fong Y
Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207).
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(11):1325-34.
1999: Li W; Fan J; Banerjee D; Bertino J R
Overexpression of p21(waf1) decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein.
Molecular pharmacology 1999;55(6):1088-93.
1999: Moskowitz C H; Nimer S D; Glassman J R; Portlock C S; Yahalom J; Straus D J; O'Brien J P; Elkin N; Bertino J R; Zelenetz A D
The International Prognostic Index predicts for outcome following autologous stem cell transplantation in patients with relapsed and primary refractory intermediate-grade lymphoma.
Bone marrow transplantation 1999;23(6):561-7.
1999: Guo W; Healey J H; Meyers P A; Ladanyi M; Huvos A G; Bertino J R; Gorlick R
Mechanisms of methotrexate resistance in osteosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):621-7.
1999: Trippett T M; Bertino J R
Therapeutic strategies targeting proteins that regulate folate and reduced folate transport.
Journal of chemotherapy (Florence, Italy) 1999;11(1):3-10.
1999: Gorlick R; Cole P; Banerjee D; Longo G; Li W W; Hochhauser D; Bertino J R
Mechanisms of methotrexate resistance in acute leukemia. Decreased transport and polyglutamylation.
Advances in experimental medicine and biology 1999;457():543-50.
1999: Sapse D S; Tong Y; Bertino J R; Sapse A M
Ab initio studies of some amino acid residue complexes with 4-mercaptopyridine as a model for thymitaq (AG337), an inhibitor of thymidylate synthase.
Cancer investigation 1999;17(6):396-401.
1999: Banerjee D; Tong Y; Liu-Chen X; Capiaux G; Ercikan-Abali E A; Takebe N; O'Connor O A; Bertino J R
Protection of bone marrow cells from toxicity of chemotherapeutic agents targeted toward thymidylate synthase by transfer of mutant forms of human thymidylate synthase cDNA.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1999;36():107-14.
1999: Bertino J R; Zhao S C; Mineishi S; Ercikan-Abali E A; Banerjee D
Use of variants of dihydrofolate reductase in gene transfer to produce resistance to methotrexate and trimetrexate.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1999;36():82-94.
1998: Chou T C; Zhang X G; Harris C R; Kuduk S D; Balog A; Savin K A; Bertino J R; Danishefsky S J
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15798-802.
1998: Tong Y; Liu-Chen X; Ercikan-Abali E A; Zhao S C; Banerjee D; Maley F; Bertino J R
Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.
The Journal of biological chemistry 1998;273(47):31209-14.
1998: Banerjee D; Schnieders B; Fu J Z; Adhikari D; Zhao S C; Bertino J R
Role of E2F-1 in chemosensitivity.
Cancer research 1998;58(19):4292-6.
1998: Chou T C; Zhang X G; Balog A; Su D S; Meng D; Savin K; Bertino J R; Danishefsky S J
Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9642-7.
1998: Gorlick R; Meyers P; Kellick M; Bertino J R
Monitoring methotrexate levels in osteosarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(6):2290-1.
1998: Mineishi S; Nakahara S; Takebe N; Zhao S C; Banerjee D; Bertino J R
Purine salvage rescue by xanthine-guanine phosphoribosyltransferase (XGPRT) potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene.
Cancer gene therapy 1998;5(3):144-9.
1998: Tong Y; Liu-Chen X; Ercikan-Abali E A; Capiaux G M; Zhao S C; Banerjee D; Bertino J R
Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.
The Journal of biological chemistry 1998;273(19):11611-8.
1998: Gorlick R; Metzger R; Danenberg K D; Salonga D; Miles J S; Longo G S; Fu J; Banerjee D; Klimstra D; Jhanwar S; Danenberg P V; Kemeny N; Bertino J R
Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(4):1465-9.
1998: Longo G S; Izzo J; Chang Y M; Tong W P; Zielinski Z; Gorlick R; Chou T C; Bertino J R
Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(2):469-73.
1998: Casper E S; Waltzman R J; Schwartz G K; Sugarman A; Pfister D; Ilson D; Woodruff J; Leung D; Bertino J R
Phase II trial of paclitaxel in patients with soft-tissue sarcoma.
Cancer investigation 1998;16(7):442-6.
1997: Bertino J R
Biomodulation of 5-fluorouracil with antifolates.
Seminars in oncology 1997;24(5 Suppl 18):S18-52-S18-56.
1997: Bertino J R
Chemotherapy of colorectal cancer: history and new themes.
Seminars in oncology 1997;24(5 Suppl 18):S18-3-S18-7.
1997: Ercikan-Abali E A; Banerjee D; Waltham M C; Skacel N; Scotto K W; Bertino J R
Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region.
Biochemistry 1997;36(40):12317-22.
1997: Longo G S; Gorlick R; Tong W P; Ercikan E; Bertino J R
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Blood 1997;90(3):1241-5.
1997: Mineishi S; Nakahara S; Takebe N; Banerjee D; Zhao S C; Bertino J R
Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene.
Gene therapy 1997;4(6):570-6.
1997: Li W W; Fan J; Hochhauser D; Bertino J R
Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells.
Cancer research 1997;57(11):2193-9.
1997: Argiris A; Longo G S; Gorlick R; Tong W; Steinherz P; Bertino J R
Increased methotrexate polyglutamylation in acute megakaryocytic leukemia (M7) compared to other subtypes of acute myelocytic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(6):886-9.
1997: Zhao S C; Banerjee D; Mineishi S; Bertino J R
Post-transplant methotrexate administration leads to improved curability of mice bearing a mammary tumor transplanted with marrow transduced with a mutant human dihydrofolate reductase cDNA.
Human gene therapy 1997;8(8):903-9.
1997: Fan J; Bertino J R
K-ras modulates the cell cycle via both positive and negative regulatory pathways.
Oncogene 1997;14(21):2595-607.
1997: Waltham M C; Li W W; Gritsman H; Tong W P; Bertino J R
gamma-Glutamyl hydrolase from human sarcoma HT-1080 cells: characterization and inhibition by glutamine antagonists.
Molecular pharmacology 1997;51(5):825-32.
1997: Fan J; Banerjee D; Stambrook P J; Bertino J R
Modulation of cytotoxicity of chemotherapeutic drugs by activated H-ras.
Biochemical pharmacology 1997;53(8):1203-9.
1997: Fan J; Bertino J R
Functional roles of E2F in cell cycle regulation.
Oncogene 1997;14(10):1191-200.
1997: Waltham M C; Lin S; Li W W; Göker E; Gritsman H; Tong W P; Bertino J R
Capillary electrophoresis of methotrexate polyglutamates and its application in evaluation of gamma-glutamyl hydrolase activity.
Journal of chromatography. B, Biomedical sciences and applications 1997;689(2):387-92.
1997: Gorlick R; Goker E; Trippett T; Steinherz P; Elisseyeff Y; Mazumdar M; Flintoff W F; Bertino J R
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.
Blood 1997;89(3):1013-8.
1997: Longo G S; Gorlick R; Tong W P; Lin S; Steinherz P; Bertino J R
gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.
Oncology research 1997;9(5):259-63.
1996: Pisters K M; Tyson L B; Tong W; Fleisher M; Miller V A; Grant S C; Pfister D G; Rigas J R; Densmore C L; Krol G; Heelan R T; Sirotnak F M; Bertino J R; Kris M G
High-dose edatrexate with oral leucovorin rescue: a phase I and clinical pharmacological study in adults with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(11):1819-24.
1996: Li W W; Cordon-Cardo C; Chen Q; Jhanwar S C; Bertino J R
Establishment, characterization and drug sensitivity of four new human soft tissue sarcoma cell lines.
International journal of cancer. Journal international du cancer 1996;68(4):514-9.
1996: Gorlick R; Goker E; Trippett T; Waltham M; Banerjee D; Bertino J R
Intrinsic and acquired resistance to methotrexate in acute leukemia.
The New England journal of medicine 1996;335(14):1041-8.
1996: Hochhauser D; Schnieders B; Ercikan-Abali E; Gorlick R; Muise-Helmericks R; Li W W; Fan J; Banerjee D; Bertino J R
Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line.
Journal of the National Cancer Institute 1996;88(18):1269-75.
1996: Ercikan-Abali E A; Mineishi S; Tong Y; Nakahara S; Waltham M C; Banerjee D; Chen W; Sadelain M; Bertino J R
Active site-directed double mutants of dihydrofolate reductase.
Cancer research 1996;56(18):4142-5.
1996: DeAngelis L M; Tong W P; Lin S; Fleisher M; Bertino J R
Carboxypeptidase G2 rescue after high-dose methotrexate.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(7):2145-9.
1996: Ercikan-Abali E A; Waltham M C; Dicker A P; Schweitzer B I; Gritsman H; Banerjee D; Bertino J R
Variants of human dihydrofolate reductase with substitutions at leucine-22: effect on catalytic and inhibitor binding properties.
Molecular pharmacology 1996;49(3):430-7.
1996: Bertino J R; Göker E; Gorlick R; Li W W; Banerjee D
Resistance mechanisms to methotrexate in tumors.
Stem cells (Dayton, Ohio) 1996;14(1):5-9.
1995: Lenz H J; Danenberg K D; Schnieders B; Banerjee D; Bertino J R; Leichman L; Danenberg P V
Identification of mutations by RNA conformational polymorphism "bar code" analysis.
Genomics 1995;30(1):120-2.
1995: Banerjee D; Lenz H J; Schnieders B; Manno D J; Ju J F; Spears C P; Hochhauser D; Danenberg K; Danenberg P; Bertino J R
Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1405-13.
1995: Li W; Fan J; Hochhauser D; Banerjee D; Zielinski Z; Almasan A; Yin Y; Kelly R; Wahl G M; Bertino J R
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10436-40.
1995: Flasshove M; Banerjee D; Bertino J R; Moore M A
Increased resistance to methotrexate in human hematopoietic cells after gene transfer of the Ser31 DHFR mutant.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9 Suppl 1():S34-7.
1995: Li W W; Tong W P; Bertino J R
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(6):631-6.
1995: Almasan A; Yin Y; Kelly R E; Lee E Y; Bradley A; Li W; Bertino J R; Wahl G M
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5436-40.
1995: Lacerda J F; Göker E; Kheradpour A; Dennig D; Elisseyeff Y; Jagiello C; O'Reilly R J; Bertino J R
Selective treatment of SCID mice bearing methotrexate-transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection.
Blood 1995;85(10):2675-9.
1995: Rosowsky A; Mota C E; Queener S F; Waltham M; Ercikan-Abali E; Bertino J R
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Journal of medicinal chemistry 1995;38(5):745-52.
1995: Conti J A; Kemeny N E; Saltz L B; André A M; Grossano D D; Bertino J R
Continuous infusion fluorouracil/leucovorin and bolus mitomycin-C as a salvage regimen for patients with advanced colorectal cancer.
Cancer 1995;75(3):769-74.
1995: Göker E; Kheradpour A; Waltham M; Banerjee D; Tong W P; Elisseyeff Y; Bertino J R
Acute monocytic leukemia: a myeloid leukemia subset that may be sensitive to methotrexate.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(2):274-6.
1995: Flasshove M; Banerjee D; Mineishi S; Li M X; Bertino J R; Moore M A
Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer.
Blood 1995;85(2):566-74.
1995: Banerjee D; Ercikan-Abali E; Waltham M; Schnieders B; Hochhauser D; Li W W; Fan J; Gorlick R; Goker E; Bertino J R
Molecular mechanisms of resistance to antifolates, a review.
Acta biochimica Polonica 1995;42(4):457-64.
1995: Kheradpour A; Berman E; Göker E; Lin J T; Tong W P; Bertino J R
A phase II study of continuous infusion of trimetrexate in patients with refractory acute leukemia.
Cancer investigation 1995;13(1):36-40.
1994: Kemeny N; Conti J A; Cohen A; Campana P; Huang Y; Shi W J; Botet J; Pulliam S; Bertino J R
Phase II study of hepatic arterial floxuridine, leucovorin, and dexamethasone for unresectable liver metastases from colorectal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(11):2288-95.
1994: Kelsen D P; Saltz L; Cohen A M; Yao T J; Enker W; Tong W; Tao Y; Bertino J R
A phase I trial of immediate postoperative intraperitoneal floxuridine and leucovorin plus systemic 5-fluorouracil and levamisole after resection of high risk colon cancer.
Cancer 1994;74(8):2224-33.
1994: Kemeny N E; Conti J A; Bertino J R
Chemotherapy for colorectal cancer.
The New England journal of medicine 1994;331(10):680-1.
1994: Horikoshi T; Lenz H J; Danenberg K; Koch O M; Bertino J R; Danenberg P V
Quantitative determination of the ratio of mutated to normal ras genes in the blood of leukemia patients by allele-specific PCR.
Leukemia research 1994;18(9):693-702.
1994: Banerjee D; Zhao S C; Tong Y; Steinherz J; Gritsman K; Bertino J R
Transfection of a nonactive site mutant murine DHFR cDNA (the tryptophan 15 mutant) into Chinese hamster ovary and mouse marrow progenitor cells imparts MTX resistance in vitro.
Cancer gene therapy 1994;1(3):181-4.
1994: Banerjee D; Zhao S C; Li M X; Schweitzer B I; Mineishi S; Bertino J R
Gene therapy utilizing drug resistance genes: a review.
Stem cells (Dayton, Ohio) 1994;12(4):378-85.
1994: Koch O M; Volkenandt M; Göker E; Buer J; Probst M; Banerjee D; Danenberg P V; Bertino J R
Molecular detection and characterization of clonal cell populations in acute lymphocytic leukemia by analysis of conformational polymorphisms of cRNA molecules of rearranged T-cell-receptor-gamma and immunoglobulin heavy-chain genes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(6):946-52.
1994: Li M X; Banerjee D; Zhao S C; Schweitzer B I; Mineishi S; Gilboa E; Bertino J R
Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction.
Blood 1994;83(11):3403-8.
1994: Conti J A; Kemeny N; Seiter K; Goker E; Tong W; André M; Ragusa K; Bertino J R
Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(4):695-700.
1994: Zhao S C; Li M X; Banerjee D; Schweitzer B I; Mineishi S; Gilboa E; Bertino J R
Long-term protection of recipient mice from lethal doses of methotrexate by marrow infected with a double-copy vector retrovirus containing a mutant dihydrofolate reductase.
Cancer gene therapy 1994;1(1):27-33.
1994: Kemeny N; Seiter K; Conti J A; Cohen A; Bertino J R; Sigurdson E R; Botet J; Chapman D; Mazumdar M; Budd A J
Hepatic arterial floxuridine and leucovorin for unresectable liver metastases from colorectal carcinoma. New dose schedules and survival update.
Cancer 1994;73(4):1134-42.
1994: Banerjee D; Schweitzer B I; Volkenandt M; Li M X; Waltham M; Mineishi S; Zhao S C; Bertino J R
Transfection with a cDNA encoding a Ser31 or Ser34 mutant human dihydrofolate reductase into Chinese hamster ovary and mouse marrow progenitor cells confers methotrexate resistance.
Gene 1994;139(2):269-74.
1994: Sapse A M; Waltham M C; Bertino J R
Ab initio studies of 2,4-diamino triazine and its complexes with ligands: a model for inhibitor-active site interactions of dihydrofolate reductase.
Cancer investigation 1994;12(5):469-76.
1994: Lenz H J; Danenberg K; Schnieders B; Goeker E; Peters G J; Garrow T; Shane B; Bertino J R; Danenberg P V
Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients.
Oncology research 1994;6(7):329-35.
1993: Dicker A P; Waltham M C; Volkenandt M; Schweitzer B I; Otter G M; Schmid F A; Sirotnak F M; Bertino J R
Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11797-801.
1993: Volkenandt M; Wienecke R; Koch O M; Buer J; Probst M; Atzpodien J; Horikoshi T; Danenberg K; Danenberg P; Bertino J R
Conformational polymorphisms of cRNA of T-cell-receptor genes as a clone-specific molecular marker for cutaneous lymphoma.
The Journal of investigative dermatology 1993;101(4):514-6.
1993: Volkenandt M; Bertino J R; Shenoy B V; Koch O M; Kadin M E
Molecular evidence for a clonal relationship between lymphomatoid papulosis and Ki-1 positive large cell anaplastic lymphoma.
Journal of dermatological science 1993;6(2):121-6.
1993: Barakat R R; Li W W; Lovelace C; Bertino J R
Intrinsic resistance of cervical squamous cell carcinoma cell lines to methotrexate (MTX) as a result of decreased accumulation of intracellular MTX polyglutamates.
Gynecologic oncology 1993;51(1):54-60.
1993: Casper E S; Christman K L; Schwartz G K; Johnson B; Brennan M F; Bertino J R
Edatrexate in patients with soft tissue sarcoma. Activity in malignant fibrous histiocytoma.
Cancer 1993;72(3):766-70.
1993: Wang F S; Aschele C; Sobrero A; Chang Y M; Bertino J R
Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance.
Cancer research 1993;53(16):3677-80.
1993: Fanin R; Banerjee D; Volkenandt M; Waltham M; Li W W; Dicker A P; Schweitzer B I; Bertino J R
Mutations leading to antifolate resistance in Chinese hamster ovary cells after exposure to the alkylating agent ethylmethanesulfonate.
Molecular pharmacology 1993;44(1):13-21.
1993: Göker E; Lin J T; Trippett T; Elisseyeff Y; Tong W P; Niedzwiecki D; Tan C; Steinherz P; Schweitzer B I; Bertino J R
Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(7):1000-4.
1993: Wienecke R; Volkenandt M; Koch O; Neubert U; McNutt N S; Danenberg P V; Bertino J R
Rapid and sensitive molecular subtyping of microorganisms in clinical specimens.
Lancet 1993;341(8848):830-1.
1993: Bertino J R
Karnofsky memorial lecture. Ode to methotrexate.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(1):5-14.
1993: Ercikan E; Banerjee D; Waltham M; Schnieders B; Scotto K W; Bertino J R
Translational regulation of the synthesis of dihydrofolate reductase.
Advances in experimental medicine and biology 1993;338():537-40.
1993: Ercikan E; Waltham M; Dicker A; Schweitzer B; Bertino J R
Effect of codon 22 mutations on substrate and inhibitor binding for human dihydrofolate reductase.
Advances in experimental medicine and biology 1993;338():515-9.
1993: Bertino J R; Göker E
Drug resistance in acute leukemia.
Leukemia & lymphoma 1993;11 Suppl 2():37-41.
1993: Li W W; Waltham M; Tong W; Schweitzer B I; Bertino J R
Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX).
Advances in experimental medicine and biology 1993;338():635-8.
1992: Li W W; Bertino J R
Inability of leucovorin to rescue a naturally methotrexate-resistant human soft tissue sarcoma cell line from trimetrexate cytotoxicity.
Cancer research 1992;52(24):6866-70.
1992: Volkenandt M; Cerroni L; Rieger E; Soyer H P; Koch O; Wienecke R; Atzpodien J; Bertino J R; Kerl H
Analysis of the 14;18 translocation in cutaneous lymphomas using the polymerase chain reaction.
Journal of cutaneous pathology 1992;19(5):353-6.
1992: Bertino J R; Li W W; Lin J; Trippett T; Goker E; Schweitzer B; Banerjee D
Enzymes of the thymidylate cycle as targets for chemotherapeutic agents: mechanisms of resistance.
The Mount Sinai journal of medicine, New York 1992;59(5):391-5.
1992: Li M; Hantzopoulos P A; Banerjee D; Zhao S C; Schweitzer B I; Gilboa E; Bertino J R
Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors.
Human gene therapy 1992;3(4):381-90.
1992: Li W W; Lin J T; Schweitzer B I; Tong W P; Niedzwiecki D; Bertino J R
Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines.
Cancer research 1992;52(14):3908-13.
1992: Romanini A; Li W W; Colofiore J R; Bertino J R
Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil, in CCRF-CEM cells.
Journal of the National Cancer Institute 1992;84(13):1033-8.
1992: Volkenandt M; Dicker A P; Banerjee D; Fanin R; Schweitzer B; Horikoshi T; Danenberg K; Danenberg P; Bertino J R
Quantitation of gene copy number and mRNA using the polymerase chain reaction.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;200(1):1-6.
1992: Marsh J C; Durivage H J; Davis C; O'Hollaren K; Pasquale D N; Simonich S A; Voynick I M; Bertino J R
Phase II study of pulse 5-fluoro-2'-deoxyuridine and leucovorin in advanced colorectal cancer patients previously treated with chemotherapy.
American journal of clinical oncology 1992;15(2):115-8.
1992: Aschele C; Sobrero A; Faderan M A; Bertino J R
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.
Cancer research 1992;52(7):1855-64.
1992: Volkenandt M; Koch O; Fanin R; Banerjee D; Seger A; Vogel J; Bierhoff E; Heidl G; Neyses L; Bertino J R
Sequence analysis of polymerase chain reaction amplified t(14;18) chromosomal breakpoints in formalin fixed, paraffin wax embedded follicular lymphoma.
Journal of clinical pathology 1992;45(3):210-2.
1992: Li W W; Lin J T; Tong W P; Trippett T M; Brennan M F; Bertino J R
Mechanisms of natural resistance to antifolates in human soft tissue sarcomas.
Cancer research 1992;52(6):1434-8.
1992: Danenberg P V; Horikoshi T; Volkenandt M; Danenberg K; Lenz H J; Shea L C; Dicker A P; Simoneau A; Jones P A; Bertino J R
Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s).
Nucleic acids research 1992;20(3):573-9.
1992: Sapse A M; Schweitzer B S; Dicker A P; Bertino J R; Frecer V
Ab initio studies of aromatic-aromatic and aromatic-polar interactions in the binding of substrate and inhibitor to dihydrofolate reductase.
International journal of peptide and protein research 1992;39(1):18-23.
1991: Li W W; Lin J T; Schweitzer B I; Bertino J R
Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.
Molecular pharmacology 1991;40(5):854-8.
1991: Li W W; Lin J T; Chang Y M; Schweitzer B; Bertino J R
Prediction of antifolate efficacy in a rat sarcoma model.
International journal of cancer. Journal international du cancer 1991;49(2):234-8.
1991: Volkenandt M; Soyer H P; Kerl H; Bertino J R
Development of a highly specific and sensitive molecular probe for detection of cutaneous lymphoma.
The Journal of investigative dermatology 1991;97(1):137-40.
1991: Bertino J R
Improving the curability of acute leukemia: pharmacologic approaches.
Seminars in hematology 1991;28(3 Suppl 4):9-11.
1991: Smith-Rogers J A; Tong W P; Duafala M E; Markman M; Bertino J R
High-performance liquid chromatographic method for the simultaneous measurement of floxuridine and fluorouracil in human body fluids.
Journal of chromatography 1991;566(1):147-54.
1991: Marsh J C; Bertino J R; Katz K H; Davis C A; Durivage H J; Rome L S; Richards F; Capizzi R L; Farber L R; Pasquale D N
The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(3):371-80.
1991: Romanini A; Lin J T; Niedzwiecki D; Bunni M; Priest D G; Bertino J R
Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin.
Cancer research 1991;51(3):789-93.
1991: Lin J T; Bertino J R
Update on trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties.
Cancer investigation 1991;9(2):159-72.
1991: Lin J T; Tong W P; Trippett T M; Niedzwiecki D; Tao Y; Tan C; Steinherz P; Schweitzer B I; Bertino J R
Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia.
Leukemia research 1991;15(12):1191-6.
1990: Cordon-Cardo C; O'Brien J P; Boccia J; Casals D; Bertino J R; Melamed M R
Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990;38(9):1277-87.
1990: Kemeny N; Cohen A; Bertino J R; Sigurdson E R; Botet J; Oderman P
Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma.
Cancer 1990;65(11):2446-50.
1990: Dicker A P; Volkenandt M; Schweitzer B I; Banerjee D; Bertino J R
Identification and characterization of a mutation in the dihydrofolate reductase gene from the methotrexate-resistant Chinese hamster ovary cell line Pro-3 MtxRIII.
The Journal of biological chemistry 1990;265(14):8317-21.
1990: Schweitzer B I; Dicker A P; Bertino J R
Dihydrofolate reductase as a therapeutic target.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(8):2441-52.
1990: Bertino J R
Folate antagonists: toward improving the therapeutic index and development of new analogs.
Journal of clinical pharmacology 1990;30(4):291-5.
1990: Bertino J R; Romanini A
Modulation of fluoropyrimidines by pretreatment with antifolates or folinic acid (leucovorin).
Cancer investigation 1990;8(2):259-60.
1989: Schweitzer B I; Srimatkandada S; Gritsman H; Sheridan R; Venkataraghavan R; Bertino J R
Probing the role of two hydrophobic active site residues in the human dihydrofolate reductase by site-directed mutagenesis.
The Journal of biological chemistry 1989;264(34):20786-95.
1989: Romanini A; Sobrero A F; Chou T C; Sherwood R F; Bertino J R
Enhancement of trimetrexate cytotoxicity in vitro and in vivo by carboxypeptidase G2.
Cancer research 1989;49(21):6019-23.
1989: Pizzorno G; Chang Y M; McGuire J J; Bertino J R
Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.
Cancer research 1989;49(19):5275-80.
1989: Dicker A P; Volkenandt M; Adamo A; Barreda C; Bertino J R
Sequence analysis of a human gene responsible for drug resistance: a rapid method for manual and automated direct sequencing of products generated by the polymerase chain reaction.
BioTechniques 1989;7(8):830-8.
1989: Smith J A; Morris A; Duafala M E; Bertino J R; Markman M; Kleinberg M
Stability of floxuridine and leucovorin calcium admixtures for intraperitoneal administration.
American journal of hospital pharmacy 1989;46(5):985-9.
1989: Srimatkandada S; Schweitzer B I; Moroson B A; Dube S; Bertino J R
Amplification of a polymorphic dihydrofolate reductase gene expressing an enzyme with decreased binding to methotrexate in a human colon carcinoma cell line, HCT-8R4, resistant to this drug.
The Journal of biological chemistry 1989;264(6):3524-8.
1989: Cordon-Cardo C; O'Brien J P; Casals D; Rittman-Grauer L; Biedler J L; Melamed M R; Bertino J R
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):695-8.
1989: Dicker A P; Volkenandt M; Bertino J R
Detection of a single base mutation in the human dihydrofolate reductase gene from a methotrexate-resistant cell line using the polymerase chain reaction.
Cancer communications 1989;1(1):7-12.
1989: Bertino J R; Lin J; Pizzorno G; Li W W; Chang Y M
The basis for intrinsic drug resistance or sensitivity to methotrexate.
Advances in enzyme regulation 1989;29():277-85.
1989: Chang Y M; Bertino J R
Enhancement of fluoropyrimidine inhibition of cell growth by leucovorin and deoxynucleosides in a human squamous cell carcinoma cell line.
Cancer investigation 1989;7(6):557-63.
1988: Bertino J R; Lin J T; Cashmore A R; Fanucchi M P; Tong W P; Stewart J A; McCormack J J
Clinical pharmacology and metabolism of trimetrexate.
Seminars in oncology 1988;15(2 Suppl 2):8-9.
1988: Bertino J R
Trimetrexate: overall clinical results.
Seminars in oncology 1988;15(2 Suppl 2):50-1.
1988: Sobrero A F; McGuire J J; Bertino J R
Uptake and metabolism of 5,8-dideazaisofolic acid in human colon carcinoma cells.
Biochemical pharmacology 1988;37(6):997-1001.
1988: Narayanan R; Jastreboff M M; Chiu C F; Ito E; Bertino J R
A method to detect transfected chloramphenicol acetyltransferase gene expression in intact animals.
Experimental cell research 1988;174(1):297-301.
1987: Lin J T; Bertino J R
Trimetrexate: a second generation folate antagonist in clinical trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987;5(12):2032-40.
1987: Portlock C S; Fischer D S; Cadman E; Lundberg W B; Levy A; Bobrow S; Bertino J R; Farber L
High-dose pulse chlorambucil in advanced, low-grade non-Hodgkin's lymphoma.
Cancer treatment reports 1987;71(11):1029-31.
1987: McGuire J J; Sobrero A F; Hynes J B; Bertino J R
Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells.
Cancer research 1987;47(22):5975-81.
1987: Jastreboff M M; Ito E; Bertino J R; Narayanan R
Use of electroporation for high-molecular-weight DNA-mediated gene transfer.
Experimental cell research 1987;171(2):513-7.
1987: Jastreboff M M; Sokoloski J A; Bertino J R; Narayanan R
Use of electroporation to study the cytotoxic effects of fluorodeoxyuridylate in intact cells.
Biochemical pharmacology 1987;36(8):1345-8.
1987: Rodenhuis S; McGuire J J; Sawicki W L; Bertino J R
Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(2):116-20.
1987: Bertino J R; Sobrero A; Mini E; Moroson B A; Cashmore A
Design and rationale for novel antifolates.
NCI monographs : a publication of the National Cancer Institute 1987;(5):87-91.
1986: Narayanan R; Jastreboff M M; Chiu C F; Bertino J R
In vivo expression of a nonselected gene transferred into murine hematopoietic stem cells by electroporation.
Biochemical and biophysical research communications 1986;141(3):1018-24.
1986: Sokoloski J A; Jastreboff M M; Bertino J R; Sartorelli A C; Narayanan R
Introduction of deoxyribonucleoside triphosphates into intact cells by electroporation.
Analytical biochemistry 1986;158(2):272-7.
1986: Reiss M; Jastreboff M M; Bertino J R; Narayanan R
DNA-mediated gene transfer into epidermal cells using electroporation.
Biochemical and biophysical research communications 1986;137(1):244-9.
1986: Todd M B; Portlock C S; Farber L R; Holford T R; Bertino J R
Prognostic indicators in diffuse large-cell (histiocytic) lymphoma.
International journal of radiation oncology, biology, physics 1986;12(4):593-601.
1986: Koletsky A J; Bertino J R; Farber L R; Prosnitz L R; Kapp D S; Fischer D; Portlock C S
Second neoplasms in patients with Hodgkin's disease following combined modality therapy--the Yale experience.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1986;4(3):311-7.
1986: Narayanan R; Jastreboff M M; Bertino J R
Development of an amphotropic, high-titer retrovirus vector expressing the dihydrofolate reductase gene and conferring methotrexate resistance.
Gene 1986;48(1):71-80.
1985: Mini E; Srimatkandada S; Medina W D; Moroson B A; Carman M D; Bertino J R
Molecular and karyological analysis of methotrexate-resistant and -sensitive human leukemic CCRF-CEM cells.
Cancer research 1985;45(1):317-24.
1985: Bertino J R; Srimatkandada S; Carman M D; Mini E; Jastreboff M; Moroson B A; Dube S K
Mechanisms of drug resistance in human leukemia.
Haematology and blood transfusion 1985;29():90-5.
1985: Bertino J R; Mini E; Sobrero A; Moroson B A; Love T; Jastreboff M; Carmen M; Srimatkandada S; Dube S
Methotrexate resistant cells as targets for selective chemotherapy.
Advances in enzyme regulation 1985;24():3-11.
1984: Carman M D; Schornagel J H; Rivest R S; Srimatkandada S; Portlock C S; Duffy T; Bertino J R
Resistance to methotrexate due to gene amplification in a patient with acute leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1984;2(1):16-20.
1983: Srimatkandada S; Medina W D; Cashmore A R; Whyte W; Engel D; Moroson B A; Franco C T; Dube S K; Bertino J R
Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate.
Biochemistry 1983;22(25):5774-81.
1983: Bertino J R; Carman M D; Weiner H L; Cashmore A; Moroson B A; Srimatkandada S; Schornagel J H; Medina W D; Dube S K
Gene amplification and altered enzymes as mechanisms for the development of drug resistance.
Cancer treatment reports 1983;67(10):901-4.
1981: Scheer D I; Srimatkandada S; Kamen B A; Dube S; Bertino J R
Organization of the methotrexate resistant mouse L5178YR dihydrofolate reductase gene and transformation of human HCT-8 cells by this gene.
Haematology and blood transfusion 1981;26():171-4.
1980: Rode W; Dolnick B J; Bertino J R
Isolation of a homogeneous preparation of human thymidylate synthetase from HeLa cells.
Biochemical pharmacology 1980;29(5):723-6.

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