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Yves Pommier

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Disorders

DNA Damage

Anatomy

Cultured Tumor Cells

Concepts & Ideas

Living Beings

HIV-1

Procedures

Antitumor Drug Screening Assays

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Co-Publications
Name
71
Kohn, Kurt
64
Kohlhagen, Glenda
42
Antony, Smitha
32
Marchand, Christophe
30
Neamati, Nouri
30
Cushman, Mark
27
Mazumder, A
24
Pourquier, Philippe
23
Burke, Terrence
22
Weinstein, John
18
Sordet, Olivier
18
Agama, Keli
14
Sunder, S
12
Johnson, Allison
12
Nicklaus, Marc

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Publications

TOP 3
Cinelli Maris A; Cordero Brenda; Dexheimer Thomas S; Pommier Yves; Cushman Mark
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
Sordet Olivier; Redon Christophe E; Guirouilh-Barbat Josée; Smith Susan; Solier Stéphanie; Douarre Céline; Conti Chiara; Nakamura Asako J; Das Benu B; Nicolas Estelle; Kohn Kurt W; Bonner William M; Pommier Yves
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
Guirouilh-Barbat Josée; Antony Smitha; Pommier Yves
Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.

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All Publications

2009: Cinelli Maris A; Cordero Brenda; Dexheimer Thomas S; Pommier Yves; Cushman Mark
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
Bioorganic & medicinal chemistry 2009;17(20):7145-55.
2009: Sordet Olivier; Redon Christophe E; Guirouilh-Barbat Josée; Smith Susan; Solier Stéphanie; Douarre Céline; Conti Chiara; Nakamura Asako J; Das Benu B; Nicolas Estelle; Kohn Kurt W; Bonner William M; Pommier Yves
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
EMBO reports 2009;10(8):887-93.
2009: Guirouilh-Barbat Josée; Antony Smitha; Pommier Yves
Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.
Molecular cancer therapeutics 2009;8(7):2007-14.
2009: Guirouilh-Barbat Josée; Zhang Yong-Wei; Pommier Yves
Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin.
Molecular cancer therapeutics 2009;8(7):1985-94.
2009: Pfister Thomas D; Reinhold William C; Agama Keli; Gupta Shalu; Khin Sonny A; Kinders Robert J; Parchment Ralph E; Tomaszewski Joseph E; Doroshow James H; Pommier Yves
Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity.
Molecular cancer therapeutics 2009;8(7):1878-84.
2009: Orina Josiah N; Calcagno Anna Maria; Wu Chung-Pu; Varma Sudhir; Shih Joanna; Lin Min; Eichler Gabriel; Weinstein John N; Pommier Yves; Ambudkar Suresh V; Gottesman Michael M; Gillet Jean-Pierre
Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database.
Molecular cancer therapeutics 2009;8(7):2057-66.
2009: Kohn Kurt W; Aladjem Mirit I; Weinstein John N; Pommier Yves
Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.
Cell cycle (Georgetown, Tex.) 2009;8(14):2281-99.
2009: Zhao Xue Zhi; Maddali Kasthuraiah; Marchand Christophe; Pommier Yves; Burke Terrence R
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.
Bioorganic & medicinal chemistry 2009;17(14):5318-24.
2009: Pommier Yves
DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition.
Chemical reviews 2009;109(7):2894-902.
2009: Solier Stéphanie; Pommier Yves
The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases.
Cell cycle (Georgetown, Tex.) 2009;8(12):1853-9.
2009: Zhao Xue Zhi; Maddali Kasthuraiah; Vu B Christie; Marchand Christophe; Hughes Stephen H; Pommier Yves; Burke Terrence R
Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.
Bioorganic & medicinal chemistry letters 2009;19(10):2714-7.
2009: Lountos George T; Tropea Joseph E; Zhang Di; Jobson Andrew G; Pommier Yves; Shoemaker Robert H; Waugh David S
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor.
Protein science : a publication of the Protein Society 2009;18(1):92-100.
2009: Marchand Christophe; Maddali Kasthuraiah; Métifiot Mathieu; Pommier Yves
HIV-1 IN inhibitors: 2010 update and perspectives.
Current topics in medicinal chemistry 2009;9(11):1016-37.
2009: Shankavaram Uma T; Varma Sudhir; Kane David; Sunshine Margot; Chary Krishna K; Reinhold William C; Pommier Yves; Weinstein John N
CellMiner: a relational database and query tool for the NCI-60 cancer cell lines.
BMC genomics 2009;10():277.
2008: Bonner William M; Redon Christophe E; Dickey Jennifer S; Nakamura Asako J; Sedelnikova Olga A; Solier Stéphanie; Pommier Yves
GammaH2AX and cancer.
Nature reviews. Cancer 2008;8(12):957-67.
2008: Aune Gregory J; Takagi Kazutaka; Sordet Olivier; Guirouilh-Barbat Josée; Antony Smitha; Bohr Vilhelm A; Pommier Yves
Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6449-55.
2008: Marinello Jessica; Marchand Christophe; Mott Bryan T; Bain Anjali; Thomas Craig J; Pommier Yves
Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants.
Biochemistry 2008;47(36):9345-54.
2008: Guirouilh-Barbat Josée; Redon Christophe; Pommier Yves
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
Molecular biology of the cell 2008;19(9):3969-81.
2008: Sordet Olivier; Larochelle Stéphane; Nicolas Estelle; Stevens Ellen V; Zhang Chao; Shokat Kevan M; Fisher Robert P; Pommier Yves
Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.
Journal of molecular biology 2008;381(3):540-9.
2008: Sordet Olivier; Goldman Abby; Redon Christophe; Solier Stéphanie; Rao V Ashutosh; Pommier Yves
Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.
The Journal of biological chemistry 2008;283(34):23200-8.
2008: Dexheimer Thomas S; Kozekova Albena; Rizzo Carmelo J; Stone Michael P; Pommier Yves
The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts.
Nucleic acids research 2008;36(12):4128-36.
2008: Dexheimer Thomas S; Antony Smitha; Marchand Christophe; Pommier Yves
Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
Anti-cancer agents in medicinal chemistry 2008;8(4):381-9.
2008: Meng Ling-Hua; Meng Zhaojing; Miao Ze-Hong; Veenstra Timothy D; Pommier Yves
Cytokeratin-RNA cross-linking mediated by the antitumor aminoflavone, 5-amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one.
The Journal of pharmacology and experimental therapeutics 2008;325(2):674-80.
2008: Laco Gary S; Pommier Yves
Role of a tryptophan anchor in human topoisomerase I structure, function and inhibition.
The Biochemical journal 2008;411(3):523-30.
2008: McLean Lancelot; Soto Ubaldo; Agama Keli; Francis Jawad; Jimenez Randi; Pommier Yves; Sowers Lawrence; Brantley Eileen
Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells.
International journal of cancer. Journal international du cancer 2008;122(7):1665-74.
2008: Liao Zhiyong; Robey Robert W; Guirouilh-Barbat Josée; To Kenneth K W; Polgar Orsolya; Bates Susan E; Pommier Yves
Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.
Molecular pharmacology 2008;73(2):490-7.
2008: Stevens Ellen V; Nishizuka Satoshi; Antony Smitha; Reimers Mark; Varma Sudhir; Young Lynn; Munson Peter J; Weinstein John N; Kohn Elise C; Pommier Yves
Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers.
Molecular cancer therapeutics 2008;7(1):10-8.
2008: Shimura Tsutomu; Torres Michael J; Martin Melvenia M; Rao V Ashutosh; Pommier Yves; Katsura Mari; Miyagawa Kiyoshi; Aladjem Mirit I
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Journal of molecular biology 2008;375(4):1152-64.
2008: Marchand Christophe; Beutler John A; Wamiru Antony; Budihas Scott; Möllmann Ute; Heinisch Lothar; Mellors John W; Le Grice Stuart F; Pommier Yves
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.
Antimicrobial agents and chemotherapy 2008;52(1):361-4.
2008: Kohn Kurt W; Aladjem Mirit I; Weinstein John N; Pommier Yves
Chromatin challenges during DNA replication: a systems representation.
Molecular biology of the cell 2008;19(1):1-7.
2008: Dexheimer Thomas S; Pommier Yves
DNA cleavage assay for the identification of topoisomerase I inhibitors.
Nature protocols 2008;3(11):1736-50.
2008: Semenova Elena A; Marchand Christophe; Pommier Yves
HIV-1 integrase inhibitors: update and perspectives.
Advances in pharmacology (San Diego, Calif.) 2008;56():199-228.
2007: Takagi Kazutaka; Dexheimer Thomas S; Redon Christophe; Sordet Olivier; Agama Keli; Lavielle Gilbert; Pierré Alain; Bates Susan E; Pommier Yves
Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.
Molecular cancer therapeutics 2007;6(12 Pt 1):3229-38.
2007: Conti Chiara; Seiler Jennifer A; Pommier Yves
The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses.
Cell cycle (Georgetown, Tex.) 2007;6(22):2760-7.
2007: Antony Smitha; Agama Keli K; Miao Ze-Hong; Takagi Kazutaka; Wright Mollie H; Robles Ana I; Varticovski Lyuba; Nagarajan Muthukaman; Morrell Andrew; Cushman Mark; Pommier Yves
Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.
Cancer research 2007;67(21):10397-405.
2007: Rao V Ashutosh; Agama Keli; Holbeck Susan; Pommier Yves
Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
Cancer research 2007;67(20):9971-9.
2007: Zhou Ming; Meng Zhaojing; Jobson Andrew G; Pommier Yves; Veenstra Timothy D
Detection of in vitro kinase generated protein phosphorylation sites using gamma[18O4]-ATP and mass spectrometry.
Analytical chemistry 2007;79(20):7603-10.
2007: Liao Chenzhong; Karki Rajeshri G; Marchand Christophe; Pommier Yves; Nicklaus Marc C
Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.
Bioorganic & medicinal chemistry letters 2007;17(19):5361-5.
2007: Jobson Andrew G; Cardellina John H; Scudiero Dominic; Kondapaka Sudhir; Zhang Hongliang; Kim Hijoo; Shoemaker Robert; Pommier Yves
Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.
Molecular pharmacology 2007;72(4):876-84.
2007: Miao Ze-Hong; Player Audrey; Shankavaram Uma; Wang Yong-Hong; Zimonjic Drazen B; Lorenzi Philip L; Liao Zhi-Yong; Liu Hong; Shimura Tsutomu; Zhang Hong-Liang; Meng Ling-Hua; Zhang Yong-Wei; Kawasaki Ernest S; Popescu Nicholas C; Aladjem Mirit I; Goldstein David J; Weinstein John N; Pommier Yves
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses.
Cancer research 2007;67(18):8752-61.
2007: Morrell Andrew; Placzek Michael; Parmley Seth; Antony Smitha; Dexheimer Thomas S; Pommier Yves; Cushman Mark
Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.
Journal of medicinal chemistry 2007;50(18):4419-30.
2007: Morrell Andrew; Placzek Michael; Parmley Seth; Grella Brian; Antony Smitha; Pommier Yves; Cushman Mark
Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors.
Journal of medicinal chemistry 2007;50(18):4388-404.
2007: Wang Yonghong; Miao Ze-Hong; Pommier Yves; Kawasaki Ernest S; Player Audrey
Characterization of mismatch and high-signal intensity probes associated with Affymetrix genechips.
Bioinformatics (Oxford, England) 2007;23(16):2088-95.
2007: Seiler Jennifer A; Conti Chiara; Syed Ali; Aladjem Mirit I; Pommier Yves
The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses.
Molecular and cellular biology 2007;27(16):5806-18.
2007: Rao V Ashutosh; Conti Chiara; Guirouilh-Barbat Josee; Nakamura Asako; Miao Ze-Hong; Davies Sally L; Saccá Barbara; Hickson Ian D; Bensimon Aaron; Pommier Yves
Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.
Molecular cancer research : MCR 2007;5(7):713-24.
2007: Meng L-H; Kohn K W; Pommier Y
Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).
Oncogene 2007;26(33):4806-16.
2007: Morrell Andrew; Placzek Michael S; Steffen Jamin D; Antony Smitha; Agama Keli; Pommier Yves; Cushman Mark
Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures.
Journal of medicinal chemistry 2007;50(9):2040-8.
2007: Pommier Yves
Finding the interface: more than an image.
Cancer biology & therapy 2007;6(4):620-3.
2007: Zhang Hongliang; Meng Ling-Hua; Pommier Yves
Mitochondrial topoisomerases and alternative splicing of the human TOP1mt gene.
Biochimie 2007;89(4):474-81.
2007: Shults Elvira E; Semenova Elena A; Johnson Allison A; Bondarenko Svetlana P; Bagryanskaya Irina Y; Gatilov Yuri V; Tolstikov Genrikh A; Pommier Yves
Synthesis and HIV-1 integrase inhibitory activity of spiroundecane(ene) derivatives.
Bioorganic & medicinal chemistry letters 2007;17(5):1362-8.
2007: Johnson Allison A; Marchand Christophe; Patil Sachindra S; Costi Roberta; Di Santo Roberto; Burke Terrence R; Pommier Yves
Probing HIV-1 integrase inhibitor binding sites with position-specific integrase-DNA cross-linking assays.
Molecular pharmacology 2007;71(3):893-901.
2007: Reinhold William C; Reimers Mark A; Maunakea Alika K; Kim Sohyoung; Lababidi Samir; Scherf Uwe; Shankavaram Uma T; Ziegler Micah S; Stewart Claudia; Kouros-Mehr Hosein; Cui Hengmi; Dolginow Douglas; Scudiero Dominic A; Pommier Yves G; Munroe David J; Feinberg Andrew P; Weinstein John N
Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells.
Molecular cancer therapeutics 2007;6(2):391-403.
2007: Antony Smitha; Marchand Christophe; Stephen Andrew G; Thibaut Laurent; Agama Keli K; Fisher Robert J; Pommier Yves
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1.
Nucleic acids research 2007;35(13):4474-84.
2006: Morrell Andrew; Antony Smitha; Kohlhagen Glenda; Pommier Yves; Cushman Mark
A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.
Journal of medicinal chemistry 2006;49(26):7740-53.
2006: Sordet Olivier; Goldman Abby; Pommier Yves
Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes.
Molecular cancer therapeutics 2006;5(12):3139-44.
2006: Miao Ze-Hong; Agama Keli; Sordet Olivier; Povirk Lawrence; Kohn Kurt W; Pommier Yves
Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.
DNA repair 2006;5(12):1489-94.
2006: Nagarajan Muthukaman; Morrell Andrew; Ioanoviciu Alexandra; Antony Smitha; Kohlhagen Glenda; Agama Keli; Hollingshead Melinda; Pommier Yves; Cushman Mark
Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles.
Journal of medicinal chemistry 2006;49(21):6283-9.
2006: Meng Ling-hua; Shankavaram Uma; Chen Chi; Agama Keli; Fu Hai-qing; Gonzalez Frank J; Weinstein John; Pommier Yves
Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.
Cancer research 2006;66(19):9656-64.
2006: Pommier Yves
Topoisomerase I inhibitors: camptothecins and beyond.
Nature reviews. Cancer 2006;6(10):789-802.
2006: Johnson Allison A; Sayer Jane M; Yagi Haruhiko; Patil Sachindra S; Debart Françoise; Maier Martin A; Corey David R; Vasseur Jean-Jacques; Burke Terrence R; Marquez Victor E; Jerina Donald M; Pommier Yves
Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
The Journal of biological chemistry 2006;281(43):32428-38.
2006: Takemura Haruyuki; Rao V Ashutosh; Sordet Olivier; Furuta Takahisa; Miao Ze-Hong; Meng Linghua; Zhang Hongliang; Pommier Yves
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
The Journal of biological chemistry 2006;281(41):30814-23.
2006: Semenova Elena A; Johnson Allison A; Marchand Christophe; Pommier Yves
Integration of human immunodeficiency virus as a target for antiretroviral therapy.
Current opinion in HIV and AIDS 2006;1(5):380-7.
2006: Antony Smitha; Agama Keli K; Miao Ze-Hong; Hollingshead Melinda; Holbeck Susan L; Wright Mollie H; Varticovski Lyuba; Nagarajan Muthukaman; Morrell Andrew; Cushman Mark; Pommier Yves
Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.
Molecular pharmacology 2006;70(3):1109-20.
2006: Tangirala Raghuram S; Antony Smitha; Agama Keli; Pommier Yves; Anderson Bradley D; Bevins Robert; Curran Dennis P
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin.
Bioorganic & medicinal chemistry 2006;14(18):6202-12.
2006: Chen Chi; Meng Linghua; Ma Xiaochao; Krausz Kristopher W; Pommier Yves; Idle Jeffrey R; Gonzalez Frank J
Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).
The Journal of pharmacology and experimental therapeutics 2006;318(3):1330-42.
2006: Nagarajan Muthukaman; Morrell Andrew; Antony Smitha; Kohlhagen Glenda; Agama Keli; Pommier Yves; Ragazzon Patricia A; Garbett Nichola C; Chaires Jonathan B; Hollingshead Melinda; Cushman Mark
Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.
Journal of medicinal chemistry 2006;49(17):5129-40.
2006: Morrell Andrew; Jayaraman Muthusamy; Nagarajan Muthukaman; Fox Brian M; Meckley Marintha Rae; Ioanoviciu Alexandra; Pommier Yves; Antony Smitha; Hollingshead Melinda; Cushman Mark
Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.
Bioorganic & medicinal chemistry letters 2006;16(16):4395-9.
2006: Miao Ze-Hong; Rao V Ashutosh; Agama Keli; Antony Smitha; Kohn Kurt W; Pommier Yves
4-nitroquinoline-1-oxide induces the formation of cellular topoisomerase I-DNA cleavage complexes.
Cancer research 2006;66(13):6540-5.
2006: Kim Yuli; Sun Yunguang; Chow Carson; Pommier Yves G; Simons S Stoney
Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation.
The Journal of steroid biochemistry and molecular biology 2006;100(1-3):3-17.
2006: Liao Zhiyong; Thibaut Laurent; Jobson Andrew; Pommier Yves
Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.
Molecular pharmacology 2006;70(1):366-72.
2006: Brantley Eileen; Antony Smitha; Kohlhagen Glenda; Meng Linghua; Agama Keli; Stinson Sherman F; Sausville Edward A; Pommier Yves
Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells.
Cancer chemotherapy and pharmacology 2006;58(1):62-72.
2006: Deng Jinxia; Kelley James A; Barchi Joseph J; Sanchez Tino; Dayam Raveendra; Pommier Yves; Neamati Nouri
Mining the NCI antiviral compounds for HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry 2006;14(11):3785-92.
2006: Pommier Yves; Weinstein John N; Aladjem Mirit I; Kohn Kurt W
Chk2 molecular interaction map and rationale for Chk2 inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2657-61.
2006: Furuta T; Hayward R L; Meng L-H; Takemura H; Aune G J; Bonner W M; Aladjem M I; Kohn K W; Pommier Y
p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
Oncogene 2006;25(20):2839-49.
2006: Morrell Andrew; Antony Smitha; Kohlhagen Glenda; Pommier Yves; Cushman Mark
Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(7):1846-9.
2006: Semenova Elena A; Johnson Allison A; Marchand Christophe; Davis David A; Yarchoan Robert; Pommier Yves
Preferential inhibition of the magnesium-dependent strand transfer reaction of HIV-1 integrase by alpha-hydroxytropolones.
Molecular pharmacology 2006;69(4):1454-60.
2006: Marchand Christophe; Antony Smitha; Kohn Kurt W; Cushman Mark; Ioanoviciu Alexandra; Staker Bart L; Burgin Alex B; Stewart Lance; Pommier Yves
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.
Molecular cancer therapeutics 2006;5(2):287-95.
2006: Xiao Xiangshu; Antony Smitha; Pommier Yves; Cushman Mark
Total synthesis and biological evaluation of 22-hydroxyacuminatine.
Journal of medicinal chemistry 2006;49(4):1408-12.
2006: Kohn Kurt W; Aladjem Mirit I; Weinstein John N; Pommier Yves
Molecular interaction maps of bioregulatory networks: a general rubric for systems biology.
Molecular biology of the cell 2006;17(1):1-13.
2006: Johnson Allison A; Santos Webster; Pais Godwin C G; Marchand Christophe; Amin Ronak; Burke Terrence R; Verdine Gregory; Pommier Yves
Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop.
The Journal of biological chemistry 2006;281(1):461-7.
2006: Kohn Kurt W; Aladjem Mirit I; Kim Sohyoung; Weinstein John N; Pommier Yves
Depicting combinatorial complexity with the molecular interaction map notation.
Molecular systems biology 2006;2():51.
2006: Marchand Christophe; Krajewski Krzysztof; Lee Hsiu-Fang; Antony Smitha; Johnson Allison A; Amin Ronak; Roller Peter; Kvaratskhelia Mamuka; Pommier Yves
Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites.
Nucleic acids research 2006;34(18):5157-65.
2006: Pommier Yves; Barcelo Juana M; Rao V Ashutosh; Sordet Olivier; Jobson Andrew G; Thibaut Laurent; Miao Ze-Hong; Seiler Jennifer A; Zhang Hongliang; Marchand Christophe; Agama Keli; Nitiss John L; Redon Christophe
Repair of topoisomerase I-mediated DNA damage.
Progress in nucleic acid research and molecular biology 2006;81():179-229.
2005: Tangirala Raghuram S; Dixon Rachel; Yang Danzhou; Ambrus Attila; Antony Smitha; Agama Keli; Pommier Yves; Curran Dennis P
Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin.
Bioorganic & medicinal chemistry letters 2005;15(21):4736-40.
2005: Rao V Ashutosh; Fan Angela M; Meng Linghua; Doe Christopher F; North Phillip S; Hickson Ian D; Pommier Yves
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Molecular and cellular biology 2005;25(20):8925-37.
2005: Pommier Yves; Marchand Christophe
Interfacial inhibitors of protein-nucleic acid interactions.
Current medicinal chemistry. Anti-cancer agents 2005;5(4):421-9.
2005: Ioanoviciu Alexandra; Antony Smitha; Pommier Yves; Staker Bart L; Stewart Lance; Cushman Mark
Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.
Journal of medicinal chemistry 2005;48(15):4803-14.
2005: Meng Ling-hua; Kohlhagen Glenda; Liao Zhi-yong; Antony Smitha; Sausville Edward; Pommier Yves
DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells.
Cancer research 2005;65(12):5337-43.
2005: Liao Zhi-Yong; Sordet Olivier; Zhang Hong-Liang; Kohlhagen Glenda; Antony Smitha; Gmeiner William H; Pommier Yves
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Cancer research 2005;65(11):4844-51.
2005: Xiao Xiangshu; Miao Ze-Hong; Antony Smitha; Pommier Yves; Cushman Mark
Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines.
Bioorganic & medicinal chemistry letters 2005;15(11):2795-8.
2005: Kohn Kurt W; Pommier Yves
Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage.
Biochemical and biophysical research communications 2005;331(3):816-27.
2005: Xiao Xiangshu; Antony Smitha; Pommier Yves; Cushman Mark
On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex.
Journal of medicinal chemistry 2005;48(9):3231-8.
2005: Staker Bart L; Feese Michael D; Cushman Mark; Pommier Yves; Zembower David; Stewart Lance; Burgin Alex B
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Journal of medicinal chemistry 2005;48(7):2336-45.
2005: Arimondo Paola B; Laco Gary S; Thomas Craig J; Halby Ludovic; Pez Didier; Schmitt Philippe; Boutorine Alexandre; Garestier Thérèse; Pommier Yves; Hecht Sidney M; Sun Jian-Sheng; Bailly Christian
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides.
Biochemistry 2005;44(11):4171-80.
2005: Pommier Yves; Cherfils Jacqueline
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery.
Trends in pharmacological sciences 2005;26(3):138-45.
2005: Pommier Yves; Johnson Allison A; Marchand Christophe
Integrase inhibitors to treat HIV/AIDS.
Nature reviews. Drug discovery 2005;4(3):236-48.
2005: Antony Smitha; Kohlhagen Glenda; Agama Keli; Jayaraman Muthusamy; Cao Shousong; Durrani Farukh A; Rustum Youcef M; Cushman Mark; Pommier Yves
Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison.
Molecular pharmacology 2005;67(2):523-30.
2005: Pommier Yves; Sordet Olivier; Rao V Ashutosh; Zhang Hongliang; Kohn Kurt W
Targeting chk2 kinase: molecular interaction maps and therapeutic rationale.
Current pharmaceutical design 2005;11(22):2855-72.
2004: Meng Ling-Hua; Zhang Hongliang; Hayward Larry; Takemura Haruyuki; Shao Rong-Guang; Pommier Yves
Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.
Cancer research 2004;64(24):9086-92.
2004: Yu Donghui; Khan Ehsan; Khaleque Md Abdul; Lee James; Laco Gary; Kohlhagen Glenda; Kharbanda Surender; Cheng Yung-Chi; Pommier Yves; Bharti Ajit
Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity.
The Journal of biological chemistry 2004;279(50):51851-61.
2004: Annereau Jean-Philippe; Szakács Gergely; Tucker Charles J; Arciello Angela; Cardarelli Carol; Collins Jennifer; Grissom Sherry; Zeeberg Barry R; Reinhold William; Weinstein John N; Pommier Yves; Paules Richard S; Gottesman Michael M
Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.
Molecular pharmacology 2004;66(6):1397-405.
2004: Nagarajan Muthukaman; Morrell Andrew; Fort Brian C; Meckley Marintha Rae; Antony Smitha; Kohlhagen Glenda; Pommier Yves; Cushman Mark
Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.
Journal of medicinal chemistry 2004;47(23):5651-61.
2004: Krajewski Krzysztof; Marchand Christophe; Long Ya-Qiu; Pommier Yves; Roller Peter P
Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.
Bioorganic & medicinal chemistry letters 2004;14(22):5595-8.
2004: Sordet Olivier; Khan Qasim A; Plo Isabelle; Pourquier Philippe; Urasaki Yoshimasa; Yoshida Akira; Antony Smitha; Kohlhagen Glenda; Solary Eric; Saparbaev Murat; Laval Jacques; Pommier Yves
Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.
The Journal of biological chemistry 2004;279(48):50499-504.
2004: Xiao Xiangshu; Antony Smitha; Kohlhagen Glenda; Pommier Yves; Cushman Mark
Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline.
The Journal of organic chemistry 2004;69(22):7495-501.
2004: Laco Gary S; Du Wu; Kohlhagen Glenda; Sayer Jane M; Jerina Donald M; Burke Thomas G; Curran Dennis P; Pommier Yves
Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies.
Bioorganic & medicinal chemistry 2004;12(19):5225-35.
2004: Xiao Xiangshu; Antony Smitha; Kohlhagen Glenda; Pommier Yves; Cushman Mark
Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors.
Bioorganic & medicinal chemistry 2004;12(19):5147-60.
2004: Pommier Yves
Camptothecins and topoisomerase I: a foot in the door. Targeting the genome beyond topoisomerase I with camptothecins and novel anticancer drugs: importance of DNA replication, repair and cell cycle checkpoints.
Current medicinal chemistry. Anti-cancer agents 2004;4(5):429-34.
2004: Sordet Olivier; Khan Qasim A; Pommier Yves
Apoptotic topoisomerase I-DNA complexes induced by oxygen radicals and mitochondrial dysfunction.
Cell cycle (Georgetown, Tex.) 2004;3(9):1095-7.
2004: Farrell Nicholas; Povirk Lawrence F; Dange Yojana; DeMasters Gerald; Gupta Mona S; Kohlhagen Glenda; Khan Qasim A; Pommier Yves; Gewirtz David A
Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells.
Biochemical pharmacology 2004;68(5):857-66.
2004: Sordet Olivier; Liao ZhiYong; Liu Hong; Antony Smitha; Stevens Ellen V; Kohlhagen Glenda; Fu Haiqing; Pommier Yves
Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis.
The Journal of biological chemistry 2004;279(32):33968-75.
2004: Bates Susan E; Medina-Pérez Wilma Y; Kohlhagen Glenda; Antony Smitha; Nadjem Tim; Robey Robert W; Pommier Yves
ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins.
The Journal of pharmacology and experimental therapeutics 2004;310(2):836-42.
2004: Mertins Susan D; Myers Timothy G; Holbeck Susan L; Medina-Perez Wilma; Wang Elaine; Kohlhagen Glenda; Pommier Yves; Bates Susan E
In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity.
Molecular cancer therapeutics 2004;3(7):849-60.
2004: Morrell Andrew; Antony Smitha; Kohlhagen Glenda; Pommier Yves; Cushman Mark
Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(14):3659-63.
2004: Kohn Kurt W; Riss Joseph; Aprelikova Olga; Weinstein John N; Pommier Yves; Barrett J Carl
Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system.
Molecular biology of the cell 2004;15(7):3042-52.
2004: Shao Rong-Guang; Cao Chun-Xia; Pommier Yves
Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
Acta pharmacologica Sinica 2004;25(6):756-62.
2004: Chrencik Jill E; Staker Bart L; Burgin Alex B; Pourquier Philippe; Pommier Yves; Stewart Lance; Redinbo Matthew R
Mechanisms of camptothecin resistance by human topoisomerase I mutations.
Journal of molecular biology 2004;339(4):773-84.
2004: Candeil Laurent; Gourdier Isabelle; Peyron Delphine; Vezzio Nadia; Copois Virginie; Bibeau Frederic; Orsetti Beatrice; Scheffer George L; Ychou Marc; Khan Qasim A; Pommier Yves; Pau Bernard; Martineau Pierre; Del Rio Maguy
ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases.
International journal of cancer. Journal international du cancer 2004;109(6):848-54.
2004: Pommier Yves; Sordet Olivier; Antony Smitha; Hayward Richard L; Kohn Kurt W
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks.
Oncogene 2004;23(16):2934-49.
2004: Svarovskaia Evguenia S; Barr Rebekah; Zhang Xuechun; Pais Godwin C G; Marchand Christophe; Pommier Yves; Burke Terrence R; Pathak Vinay K
Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions.
Journal of virology 2004;78(7):3210-22.
2004: Aladjem Mirit I; Pasa Stefania; Parodi Silvio; Weinstein John N; Pommier Yves; Kohn Kurt W
Molecular interaction maps--a diagrammatic graphical language for bioregulatory networks.
Science's STKE : signal transduction knowledge environment 2004;2004(222):pe8.
2004: Zhang Xuechun; Marchand Christophe; Pommier Yves; Burke Terrence R
Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.
Bioorganic & medicinal chemistry letters 2004;14(5):1205-7.
2004: Rapisarda Annamaria; Uranchimeg Badarch; Sordet Olivier; Pommier Yves; Shoemaker Robert H; Melillo Giovanni
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.
Cancer research 2004;64(4):1475-82.
2004: Johnson Allison A; Sayer Jane M; Yagi Haruhiko; Kalena Govind P; Amin Ronak; Jerina Donald M; Pommier Yves
Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates.
The Journal of biological chemistry 2004;279(9):7947-55.
2004: Antony Smitha; Theruvathu Jacob A; Brooks P J; Lesher Diem-Thu; Redinbo Matt; Pommier Yves
Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine.
Nucleic acids research 2004;32(18):5685-92.
2004: Antony Smitha; Arimondo Paola B; Sun Jian-Sheng; Pommier Yves
Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures.
Nucleic acids research 2004;32(17):5163-73.
2004: Johnson Allison A; Marchand Christophe; Pommier Yves
HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial.
Current topics in medicinal chemistry 2004;4(10):1059-77.
2004: Zhang Hongliang; Meng Ling-Hua; Zimonjic Drazen B; Popescu Nicholas C; Pommier Yves
Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases.
Nucleic acids research 2004;32(7):2087-92.
2003: Nagarajan Muthukaman; Xiao Xiangshu; Antony Smitha; Kohlhagen Glenda; Pommier Yves; Cushman Mark
Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.
Journal of medicinal chemistry 2003;46(26):5712-24.
2003: Pommier Yves; Redon Christophe; Rao V Ashutosh; Seiler Jennifer A; Sordet Olivier; Takemura Haruyuki; Antony Smitha; Meng LingHua; Liao ZhiYong; Kohlhagen Glenda; Zhang HongLiang; Kohn Kurt W
Repair of and checkpoint response to topoisomerase I-mediated DNA damage.
Mutation research 2003;532(1-2):173-203.
2003: Antony Smitha; Jayaraman Muthusamy; Laco Gary; Kohlhagen Glenda; Kohn Kurt W; Cushman Mark; Pommier Yves
Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.
Cancer research 2003;63(21):7428-35.
2003: Kim Myoung Sook; Blake Mellissa; Baek Jin Hyen; Kohlhagen Glenda; Pommier Yves; Carrier France
Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA.
Cancer research 2003;63(21):7291-300.
2003: Weinstein John N; Pommier Yves
Transcriptomic analysis of the NCI-60 cancer cell lines.
Comptes rendus biologies 2003;326(10-11):909-20.
2003: Khan Qasim A; Kohlhagen Glenda; Marshall Richard; Austin Caroline A; Kalena Govind P; Kroth Heiko; Sayer Jane M; Jerina Donald M; Pommier Yves
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12498-503.
2003: Plo Isabelle; Liao Zhi Yong; Barceló Juana M; Kohlhagen Glenda; Caldecott Keith W; Weinfeld Michael; Pommier Yves
Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions.
DNA repair 2003;2(10):1087-100.
2003: Krajewski Krzysztof; Long Ya-Qiu; Marchand Christophe; Pommier Yves; Roller Peter P
Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.
Bioorganic & medicinal chemistry letters 2003;13(19):3203-5.
2003: Marchand Christophe; Johnson Allison A; Karki Rajeshri G; Pais Godwin C G; Zhang Xuechun; Cowansage Kiriana; Patel Tapan A; Nicklaus Marc C; Burke Terrence R; Pommier Yves
Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).
Molecular pharmacology 2003;64(3):600-9.
2003: Yoshida Akira; Urasaki Yoshimasa; Waltham Mark; Bergman Ann-Charlotte; Pourquier Philippe; Rothwell Dominic G; Inuzuka Manabu; Weinstein John N; Ueda Takanori; Appella Ettore; Hickson Ian D; Pommier Yves
Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis.
The Journal of biological chemistry 2003;278(39):37768-76.
2003: Fox Brian M; Xiao Xiangshu; Antony Smitha; Kohlhagen Glenda; Pommier Yves; Staker Bart L; Stewart Lance; Cushman Mark
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
Journal of medicinal chemistry 2003;46(15):3275-82.
2003: Sordet Olivier; Khan Qasim A; Kohn Kurt W; Pommier Yves
Apoptosis induced by topoisomerase inhibitors.
Current medicinal chemistry. Anti-cancer agents 2003;3(4):271-90.
2003: Gmeiner William H; Yu Shuyuan; Pon Richard T; Pourquier Philippe; Pommier Yves
Structural basis for topoisomerase I inhibition by nucleoside analogs.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):653-8.
2003: Furuta Takahisa; Takemura Haruyuki; Liao Zhi-Yong; Aune Gregory J; Redon Christophe; Sedelnikova Olga A; Pilch Duane R; Rogakou Emmy P; Celeste Arkady; Chen Hua Tang; Nussenzweig Andre; Aladjem Mirit I; Bonner William M; Pommier Yves
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
The Journal of biological chemistry 2003;278(22):20303-12.
2003: Chrencik Jill E; Burgin Alex B; Pommier Yves; Stewart Lance; Redinbo Matthew R
Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex.
The Journal of biological chemistry 2003;278(14):12461-6.
2003: Zhang Xuechun; Pais Godwin C G; Svarovskaia Evguenia S; Marchand Christophe; Johnson Allison A; Karki Rajeshri G; Nicklaus Marc C; Pathak Vinay K; Pommier Yves; Burke Terrence R
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(6):1215-9.
2003: Reinhold William C; Kouros-Mehr Hosein; Kohn Kurt W; Maunakea Alika K; Lababidi Samir; Roschke Anna; Stover Kristen; Alexander Jes; Pantazis Panayotis; Miller Lance; Liu Edison; Kirsch Ilan R; Urasaki Yoshimasa; Pommier Yves; Weinstein John N
Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping.
Cancer research 2003;63(5):1000-11.
2003: Meng Ling-Hua; Liao Zhi-Yong; Pommier Yves
Non-camptothecin DNA topoisomerase I inhibitors in cancer therapy.
Current topics in medicinal chemistry 2003;3(3):305-20.
2002: Neamati Nouri; Lin Zhaiwei; Karki Rajeshri G; Orr Ann; Cowansage Kiriana; Strumberg Dirk; Pais Godwin C G; Voigt Johannes H; Nicklaus Marc C; Winslow Heather E; Zhao He; Turpin Jim A; Yi Jizu; Skalka Anna Marie; Burke Terrence R; Pommier Yves
Metal-dependent inhibition of HIV-1 integrase.
Journal of medicinal chemistry 2002;45(26):5661-70.
2002: Yu Qiang; La Rose JiHyun; Zhang Hongliang; Takemura Haruyuki; Kohn Kurt W; Pommier Yves
UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
Cancer research 2002;62(20):5743-8.
2002: Gourdier Isabelle; Del Rio Maguy; Crabbé Laure; Candeil Laurent; Copois Virginie; Ychou Marc; Auffray Charles; Martineau Pierre; Mechti Nadir; Pommier Yves; Pau Bernard
Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma.
FEBS letters 2002;529(2-3):232-6.
2002: Furuta Takahisa; Ueda Takahiro; Aune Gregory; Sarasin Alain; Kraemer Kenneth H; Pommier Yves
Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells.
Cancer research 2002;62(17):4899-902.
2002: Pourquier Philippe; Gioffre Christopher; Kohlhagen Glenda; Urasaki Yoshimasa; Goldwasser François; Hertel Lary W; Yu Shuyuan; Pon Richard T; Gmeiner William H; Pommier Yves
Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2499-504.
2002: Plo Isabelle; Hernandez Hélène; Kohlhagen Glenda; Lautier Dominique; Pommier Yves; Laurent Guy
Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells.
The Journal of biological chemistry 2002;277(35):31407-15.
2002: Xu Guozhang; Kannan Arunachalam; Hartman Tracy L; Wargo Heather; Watson Karen; Turpin Jim A; Buckheit Robert W; Johnson Allison A; Pommier Yves; Cushman Mark
Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents.
Bioorganic & medicinal chemistry 2002;10(8):2807-16.
2002: Aune Gregory J; Furuta Takahisa; Pommier Yves
Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action.
Anti-cancer drugs 2002;13(6):545-55.
2002: Pais Godwin C G; Zhang Xuechun; Marchand Christophe; Neamati Nouri; Cowansage Kiriana; Svarovskaia Evguenia S; Pathak Vinay K; Tang Yun; Nicklaus Marc; Pommier Yves; Burke Terrence R
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 2002;45(15):3184-94.
2002: Pommier Yves; Kohlhagen Glenda; Laco Gary S; Kroth Heiko; Sayer Jane M; Jerina Donald M
Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site.
The Journal of biological chemistry 2002;277(16):13666-72.
2002: Marchand Christophe; Zhang Xuechun; Pais Godwin C G; Cowansage Kiriana; Neamati Nouri; Burke Terrence R; Pommier Yves
Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.
The Journal of biological chemistry 2002;277(15):12596-603.
2002: Zhou Yi; Gwadry Fuad G; Reinhold William C; Miller Lance D; Smith Lawrence H; Scherf Uwe; Liu Edison T; Kohn Kurt W; Pommier Yves; Weinstein John N
Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects.
Cancer research 2002;62(6):1688-95.
2002: Marchand Christophe; Pourquier Philippe; Laco Gary S; Jing Naijie; Pommier Yves
Interaction of human nuclear topoisomerase I with guanosine quartet-forming and guanosine-rich single-stranded DNA and RNA oligonucleotides.
The Journal of biological chemistry 2002;277(11):8906-11.
2002: Laco Gary S; Collins Jack R; Luke Brian T; Kroth Heiko; Sayer Jane M; Jerina Donald M; Pommier Yves
Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model.
Biochemistry 2002;41(5):1428-35.
2002: Melek Meni; Jones Jessica M; O'Dea Mary H; Pais Godwin; Burke Terrence R; Pommier Yves; Neamati Nouri; Gellert Martin
Effect of HIV integrase inhibitors on the RAG1/2 recombinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):134-7.
2002: Jayaraman Muthusamy; Fox Brian M; Hollingshead Melinda; Kohlhagen Glenda; Pommier Yves; Cushman Mark
Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model.
Journal of medicinal chemistry 2002;45(1):242-9.
2001: Fan Y; Shi L M; Kohn K W; Pommier Y; Weinstein J N
Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.
Journal of medicinal chemistry 2001;44(20):3254-63.
2001: Yu Q; Rose J H; Zhang H; Pommier Y
Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells.
FEBS letters 2001;505(1):7-12.
2001: Zhang H; Barceló J M; Lee B; Kohlhagen G; Zimonjic D B; Popescu N C; Pommier Y
Human mitochondrial topoisomerase I.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10608-13.
2001: Takebayashi Y; Pourquier P; Zimonjic D B; Nakayama K; Emmert S; Ueda T; Urasaki Y; Kanzaki A; Akiyama S I; Popescu N; Kraemer K H; Pommier Y
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.
Nature medicine 2001;7(8):961-6.
2001: Zhang X; Neamati N; Lee Y K; Orr A; Brown R D; Whitaker N; Pommier Y; Burke T R
Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase.
Bioorganic & medicinal chemistry 2001;9(7):1649-57.
2001: Shao R G; Cao C X; Nieves-Neira W; Dimanche-Boitrel M T; Solary E; Pommier Y
Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells.
Oncogene 2001;20(15):1852-9.
2001: Urasaki Y; Laco G S; Pourquier P; Takebayashi Y; Kohlhagen G; Gioffre C; Zhang H; Chatterjee D; Pantazis P; Pommier Y
Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.
Cancer research 2001;61(5):1964-9.
2001: Urasaki Y; Laco G; Takebayashi Y; Bailly C; Kohlhagen G; Pommier Y
Use of camptothecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site.
Cancer research 2001;61(2):504-8.
2001: Takebayashi Y; Goldwasser F; Urasaki Y; Kohlhagen G; Pommier Y
Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(1):185-91.
2001: Pourquier P; Waltman J L; Urasaki Y; Loktionova N A; Pegg A E; Nitiss J L; Pommier Y
Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.
Cancer research 2001;61(1):53-8.
2001: Marchand C; Neamati N; Pommier Y
In vitro human immunodeficiency virus type 1 integrase assays.
Methods in enzymology 2001;340():624-33.
2001: Pourquier P; Pommier Y
Topoisomerase I-mediated DNA damage.
Advances in cancer research 2001;80():189-216.
2000: Urasaki Y; Takebayashi Y; Pommier Y
Activity of a novel camptothecin analogue, homocamptothecin, in camptothecin-resistant cell lines with topoisomerase I alterations.
Cancer research 2000;60(23):6577-80.
2000: Chen I J; Neamati N; Nicklaus M C; Orr A; Anderson L; Barchi J J; Kelley J A; Pommier Y; MacKerell A D
Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets.
Bioorganic & medicinal chemistry 2000;8(10):2385-98.
2000: Bom D; Curran D P; Kruszewski S; Zimmer S G; Thompson Strode J; Kohlhagen G; Du W; Chavan A J; Fraley K A; Bingcang A L; Latus L J; Pommier Y; Burke T G
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.
Journal of medicinal chemistry 2000;43(21):3970-80.
2000: Cushman M; Jayaraman M; Vroman J A; Fukunaga A K; Fox B M; Kohlhagen G; Strumberg D; Pommier Y
Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.
Journal of medicinal chemistry 2000;43(20):3688-98.
2000: Pilon A A; Marchand C; Kavlick M F; Bajaj K; Owen J; Mitsuya H; Pommier Y
Mutations in the HIV type 1 integrase of patients receiving long-term dideoxynucleoside therapy do not confer resistance to zidovudine.
AIDS research and human retroviruses 2000;16(14):1417-22.
2000: Pommier Y; Laco G S; Kohlhagen G; Sayer J M; Kroth H; Jerina D M
Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10739-44.
2000: Pommier Y; Marchand C; Neamati N
Retroviral integrase inhibitors year 2000: update and perspectives.
Antiviral research 2000;47(3):139-48.
2000: Strumberg D; Pilon A A; Smith M; Hickey R; Malkas L; Pommier Y
Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff.
Molecular and cellular biology 2000;20(11):3977-87.
2000: Fertala J; Vance J R; Pourquier P; Pommier Y; Bjornsti M A
Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.
The Journal of biological chemistry 2000;275(20):15246-53.
2000: Rogakou E P; Nieves-Neira W; Boon C; Pommier Y; Bonner W M
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.
The Journal of biological chemistry 2000;275(13):9390-5.
2000: Scherf U; Ross D T; Waltham M; Smith L H; Lee J K; Tanabe L; Kohn K W; Reinhold W C; Myers T G; Andrews D T; Scudiero D A; Eisen M B; Sausville E A; Pommier Y; Botstein D; Brown P O; Weinstein J N
A gene expression database for the molecular pharmacology of cancer.
Nature genetics 2000;24(3):236-44.
2000: Pommier Y; Kohlhagen G; Pourquier P; Sayer J M; Kroth H; Jerina D M
Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2040-5.
2000: Pourquier P; Takebayashi Y; Urasaki Y; Gioffre C; Kohlhagen G; Pommier Y
Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1885-90.
2000: Kohn K W; Shao R G; Pommier Y
How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?
Cell biochemistry and biophysics 2000;33(2):175-80.
2000: Kohn K W; Pommier Y
Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors.
Annals of the New York Academy of Sciences 2000;922():11-26.
2000: Neamati N; Marchand C; Pommier Y
HIV-1 integrase inhibitors: past, present, and future.
Advances in pharmacology (San Diego, Calif.) 2000;49():147-65.
1999: Brangi M; Litman T; Ciotti M; Nishiyama K; Kohlhagen G; Takimoto C; Robey R; Pommier Y; Fojo T; Bates S E
Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.
Cancer research 1999;59(23):5938-46.
1999: Wang Y X; Neamati N; Jacob J; Palmer I; Stahl S J; Kaufman J D; Huang P L; Huang P L; Winslow H E; Pommier Y; Wingfield P T; Lee-Huang S; Bax A; Torchia D A
Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions.
Cell 1999;99(4):433-42.
1999: Strumberg D; Nitiss J L; Dong J; Kohn K W; Pommier Y
Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.
The Journal of biological chemistry 1999;274(40):28246-55.
1999: Nieves-Neira W; Rivera M I; Kohlhagen G; Hursey M L; Pourquier P; Sausville E A; Pommier Y
DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells.
Molecular pharmacology 1999;56(3):478-84.
1999: Neamati N; Turpin J A; Winslow H E; Christensen J L; Williamson K; Orr A; Rice W G; Pommier Y; Garofalo A; Brizzi A; Campiani G; Fiorini I; Nacci V
Thiazolothiazepine inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1999;42(17):3334-41.
1999: Goldwasser F; Bae I; Pommier Y; Fornace A J
Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation.
Anticancer research 1999;19(4B):3167-71.
1999: Nieves-Neira W; Pommier Y
Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways.
International journal of cancer. Journal international du cancer 1999;82(3):396-404.
1999: Takebayashi Y; Pourquier P; Yoshida A; Kohlhagen G; Pommier Y
Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7196-201.
1999: Lin Z; Neamati N; Zhao H; Kiryu Y; Turpin J A; Aberham C; Strebel K; Kohn K; Witvrouw M; Pannecouque C; Debyser Z; De Clercq E; Rice W G; Pommier Y; Burke T R
Chicoric acid analogues as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 1999;42(8):1401-14.
1999: Pourquier P; Jensen A D; Gong S S; Pommier Y; Rogler C E
Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro.
Nucleic acids research 1999;27(8):1919-25.
1999: Pourquier P; Ueng L M; Fertala J; Wang D; Park H J; Essigmann J M; Bjornsti M A; Pommier Y
Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine.
The Journal of biological chemistry 1999;274(13):8516-23.
1999: Strumberg D; Nitiss J L; Rose A; Nicklaus M C; Pommier Y
Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.
The Journal of biological chemistry 1999;274(11):7292-301.
1999: Shao R G; Cao C X; Zhang H; Kohn K W; Wold M S; Pommier Y
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
The EMBO journal 1999;18(5):1397-406.
1999: Carrier F; Georgel P T; Pourquier P; Blake M; Kontny H U; Antinore M J; Gariboldi M; Myers T G; Weinstein J N; Pommier Y; Fornace A J
Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.
Molecular and cellular biology 1999;19(3):1673-85.
1999: Koo H M; Gray-Goodrich M; Kohlhagen G; McWilliams M J; Jeffers M; Vaigro-Wolff A; Alvord W G; Monks A; Paull K D; Pommier Y; Vande Woude G F
The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis.
Journal of the National Cancer Institute 1999;91(3):236-44.
1999: Strumberg D; Pommier Y; Paull K; Jayaraman M; Nagafuji P; Cushman M
Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
Journal of medicinal chemistry 1999;42(3):446-57.
1999: Pommier Y; Neamati N
Inhibitors of human immunodeficiency virus integrase.
Advances in virus research 1999;52():427-58.
1998: Pourquier P; Pommier Y
[Topoisomerases I: new targets for the treatment of cancer and mechanisms of resistance]
Bulletin du cancer 1998;Spec No():5-10.
1998: Hiraoka W; Vazquez N; Nieves-Neira W; Chanock S J; Pommier Y
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.
The Journal of clinical investigation 1998;102(11):1961-8.
1998: Hong H; Neamati N; Winslow H E; Christensen J L; Orr A; Pommier Y; Milne G W
Identification of HIV-1 integrase inhibitors based on a four-point pharmacophore.
Antiviral chemistry & chemotherapy 1998;9(6):461-72.
1998: Pourquier P; Bjornsti M A; Pommier Y
Induction of topoisomerase I cleavage complexes by the vinyl chloride adduct 1,N6-ethenoadenine.
The Journal of biological chemistry 1998;273(42):27245-9.
1998: Pommier Y; Pourquier P; Fan Y; Strumberg D
Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme.
Biochimica et biophysica acta 1998;1400(1-3):83-105.
1998: Neamati N; Hong H; Owen J M; Sunder S; Winslow H E; Christensen J L; Zhao H; Burke T R; Milne G W; Pommier Y
Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.
Journal of medicinal chemistry 1998;41(17):3202-9.
1998: Neamati N; Mazumder A; Sunder S; Owen J M; Tandon M; Lown J W; Pommier Y
Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase.
Molecular pharmacology 1998;54(2):280-90.
1998: Kohlhagen G; Paull K D; Cushman M; Nagafuji P; Pommier Y
Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.
Molecular pharmacology 1998;54(1):50-8.
1998: Yoshida A; Pourquier P; Pommier Y
Purification and characterization of a Mg2+-dependent endonuclease (AN34) from etoposide-treated human leukemia HL-60 cells undergoing apoptosis.
Cancer research 1998;58(12):2576-82.
1998: Fan Y; Weinstein J N; Kohn K W; Shi L M; Pommier Y
Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.
Journal of medicinal chemistry 1998;41(13):2216-26.
1998: Shimizu T; Cao C X; Shao R G; Pommier Y
Lamin B phosphorylation by protein kinase calpha and proteolysis during apoptosis in human leukemia HL60 cells.
The Journal of biological chemistry 1998;273(15):8669-74.
1998: Pommier Y
Diversity of DNA topoisomerases I and inhibitors.
Biochimie 1998;80(3):255-70.
1998: Pommier Y; Kohlhagen G; Wu C; Simmons D T
Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen.
Biochemistry 1998;37(11):3818-23.
1998: Parker B W; Kaur G; Nieves-Neira W; Taimi M; Kohlhagen G; Shimizu T; Losiewicz M D; Pommier Y; Sausville E A; Senderowicz A M
Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol.
Blood 1998;91(2):458-65.
1997: Neamati N; Hong H; Sunder S; Milne G W; Pommier Y
Potent inhibitors of human immunodeficiency virus type 1 integrase: identification of a novel four-point pharmacophore and tetracyclines as novel inhibitors.
Molecular pharmacology 1997;52(6):1041-55.
1997: Shao R G; Cao C X; Pommier Y
Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells.
The Journal of biological chemistry 1997;272(50):31321-5.
1997: Pourquier P; Pilon A A; Kohlhagen G; Mazumder A; Sharma A; Pommier Y
Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects.
The Journal of biological chemistry 1997;272(42):26441-7.
1997: Pondarré C; Strumberg D; Fujimori A; Torres-León R; Pommier Y
In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells.
Nucleic acids research 1997;25(20):4111-6.
1997: Gupta M; Fan S; Zhan Q; Kohn K W; O'Connor P M; Pommier Y
Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(9):1653-60.
1997: Shao R G; Cao C X; Shimizu T; O'Connor P M; Kohn K W; Pommier Y
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
Cancer research 1997;57(18):4029-35.
1997: Mazumder A; Neamati N; Sunder S; Schulz J; Pertz H; Eich E; Pommier Y
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.
Journal of medicinal chemistry 1997;40(19):3057-63.
1997: Shimizu T; Pommier Y
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(8):1238-44.
1997: Shao R G; Shimizu T; Pommier Y
7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
Experimental cell research 1997;234(2):388-97.
1997: Valenti M; Nieves-Neira W; Kohlhagen G; Kohn K W; Wall M E; Wani M C; Pommier Y
Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells.
Molecular pharmacology 1997;52(1):82-7.
1997: Zhao H; Neamati N; Mazumder A; Sunder S; Pommier Y; Burke T R
Arylamide inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1997;40(8):1186-94.
1997: Chen A Y; Okunieff P; Pommier Y; Mitchell J B
Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives.
Cancer research 1997;57(8):1529-36.
1997: Mazumder A; Uchida H; Neamati N; Sunder S; Jaworska-Maslanka M; Wickstrom E; Zeng F; Jones R A; Mandes R F; Chenault H K; Pommier Y
Probing interactions between viral DNA and human immunodeficiency virus type 1 integrase using dinucleotides.
Molecular pharmacology 1997;51(4):567-75.
1997: Neamati N; Hong H; Mazumder A; Wang S; Sunder S; Nicklaus M C; Milne G W; Proksa B; Pommier Y
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
Journal of medicinal chemistry 1997;40(6):942-51.
1997: Zhao H; Neamati N; Sunder S; Hong H; Wang S; Milne G W; Pommier Y; Burke T R
Hydrazide-containing inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1997;40(6):937-41.
1997: Hong H; Neamati N; Wang S; Nicklaus M C; Mazumder A; Zhao H; Burke T R; Pommier Y; Milne G W
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
Journal of medicinal chemistry 1997;40(6):930-6.
1997: Nicklaus M C; Neamati N; Hong H; Mazumder A; Sunder S; Chen J; Milne G W; Pommier Y
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.
Journal of medicinal chemistry 1997;40(6):920-9.
1997: Pourquier P; Ueng L M; Kohlhagen G; Mazumder A; Gupta M; Kohn K W; Pommier Y
Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.
The Journal of biological chemistry 1997;272(12):7792-6.
1997: Neamati N; Mazumder A; Zhao H; Sunder S; Burke T R; Schultz R J; Pommier Y
Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.
Antimicrobial agents and chemotherapy 1997;41(2):385-93.
1997: Zhao H; Neamati N; Hong H; Mazumder A; Wang S; Sunder S; Milne G W; Pommier Y; Burke T R
Coumarin-based inhibitors of HIV integrase.
Journal of medicinal chemistry 1997;40(2):242-9.
1997: Hoki Y; Fujimori A; Pommier Y
Differential cytotoxicity of clinically important camptothecin derivatives in P-glycoprotein-overexpressing cell lines.
Cancer chemotherapy and pharmacology 1997;40(5):433-8.
1996: Goldwasser F; Shimizu T; Pommier Y
Failure in DNA elongation predicts sensitivity to camptothecin in the colon cell lines of the NCI Anticancer Drug Screen.
Annals of the New York Academy of Sciences 1996;803():308-9.
1996: Pommier Y; Gupta M; Valenti M; Nieves-Neira W
Cellular resistance to camptothecins.
Annals of the New York Academy of Sciences 1996;803():60-73.
1996: Buolamwini J K; Raghavan K; Fesen M R; Pommier Y; Kohn K W; Weinstein J N
Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.
Pharmaceutical research 1996;13(12):1892-5.
1996: Fujimori A; Gupta M; Hoki Y; Pommier Y
Acquired camptothecin resistance of human breast cancer MCF-7/C4 cells with normal topoisomerase I and elevated DNA repair.
Molecular pharmacology 1996;50(6):1472-8.
1996: Mazumder A; Neamati N; Pilon A A; Sunder S; Pommier Y
Chemical trapping of ternary complexes of human immunodeficiency virus type 1 integrase, divalent metal, and DNA substrates containing an abasic site. Implications for the role of lysine 136 in DNA binding.
The Journal of biological chemistry 1996;271(44):27330-8.
1996: Mazumder A; Neamati N; Ojwang J O; Sunder S; Rando R F; Pommier Y
Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures.
Biochemistry 1996;35(43):13762-71.
1996: Pommier Y; Kohlhagen G; Bailly C; Waring M; Mazumder A; Kohn K W
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.
Biochemistry 1996;35(41):13303-9.
1996: Goldwasser F; Shimizu T; Jackman J; Hoki Y; O'Connor P M; Kohn K W; Pommier Y
Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.
Cancer research 1996;56(19):4430-7.
1996: Shao R G; Shimizu T; Pommier Y
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.
Experimental cell research 1996;227(2):190-6.
1996: Shimizu T; Pommier Y
DNA fragmentation induced by protease activation in p53-null human leukemia HL60 cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: cell-free system studies.
Experimental cell research 1996;226(2):292-301.
1996: Mazumder A; Wang S; Neamati N; Nicklaus M; Sunder S; Chen J; Milne G W; Rice W G; Burke T R; Pommier Y
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
Journal of medicinal chemistry 1996;39(13):2472-81.
1996: Goldwasser F; Valenti M; Torres R; Kohn K W; Pommier Y
Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(4):687-93.
1996: Mazumder A; Neamati N; Sommadossi J P; Gosselin G; Schinazi R F; Imbach J L; Pommier Y
Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase.
Molecular pharmacology 1996;49(4):621-8.
1996: Solary E; Dubrez L; Eymin B; Bertrand R; Pommier Y
[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors]
Bulletin du cancer 1996;83(3):205-12.
1996: Pommier Y
Eukaryotic DNA topoisomerase I: genome gatekeeper and its intruders, camptothecins.
Seminars in oncology 1996;23(1 Suppl 3):3-10.
1996: Eich E; Pertz H; Kaloga M; Schulz J; Fesen M R; Mazumder A; Pommier Y
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
Journal of medicinal chemistry 1996;39(1):86-95.
1996: Goldwasser F; Bae I; Fornace A J; Pommier Y
Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines.
Oncology research 1996;8(7-8):317-23.
1996: Fujimori A; Hoki Y; Popescu N C; Pommier Y
Silencing and selective methylation of the normal topoisomerase I gene in camptothecin-resistant CEM/C2 human leukemia cells.
Oncology research 1996;8(7-8):295-301.
1995: Ojwang J O; Buckheit R W; Pommier Y; Mazumder A; De Vreese K; Esté J A; Reymen D; Pallansch L A; Lackman-Smith C; Wallace T L
T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1995;39(11):2426-35.
1995: Mazumder A; Gazit A; Levitzki A; Nicklaus M; Yung J; Kohlhagen G; Pommier Y
Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.
Biochemistry 1995;34(46):15111-22.
1995: Eymin B; Solary E; Chevillard S; Dubrez L; Goldwasser F; Duchamp O; Genne P; Leteurtre F; Pommier Y
Cellular pharmacology of azatoxins (topoisomerase-II and tubulin inhibitors) in P-glycoprotein-positive and -negative cell lines.
International journal of cancer. Journal international du cancer 1995;63(2):268-75.
1995: Gupta M; Abdel-Megeed M; Hoki Y; Kohlhagen G; Paull K; Pommier Y
Eukaryotic DNA topoisomerases mediated DNA cleavage induced by a new inhibitor: NSC 665517.
Molecular pharmacology 1995;48(4):658-65.
1995: Burke T R; Fesen M R; Mazumder A; Wang J; Carothers A M; Grunberger D; Driscoll J; Kohn K; Pommier Y
Hydroxylated aromatic inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1995;38(21):4171-8.
1995: Pommier Y; Kohlhagen G; Kohn K W; Leteurtre F; Wani M C; Wall M E
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8861-5.
1995: Pommier Y; Jenkins J; Kohlhagen G; Leteurtre F
DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors.
Mutation research 1995;337(2):135-45.
1995: Hawkins M E; Pfleiderer W; Mazumder A; Pommier Y G; Balis F M
Incorporation of a fluorescent guanosine analog into oligonucleotides and its application to a real time assay for the HIV-1 integrase 3'-processing reaction.
Nucleic acids research 1995;23(15):2872-80.
1995: Mazumder A; Pommier Y
Processing of deoxyuridine mismatches and abasic sites by human immunodeficiency virus type-1 integrase.
Nucleic acids research 1995;23(15):2865-71.
1995: Dubrez L; Goldwasser F; Genne P; Pommier Y; Solary E
The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(6):1013-24.
1995: Gupta M; Fujimori A; Pommier Y
Eukaryotic DNA topoisomerases I.
Biochimica et biophysica acta 1995;1262(1):1-14.
1995: Tanizawa A; Kohn K W; Kohlhagen G; Leteurtre F; Pommier Y
Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives.
Biochemistry 1995;34(21):7200-6.
1995: Leteurtre F; Sackett D L; Madalengoitia J; Kohlhagen G; MacDonald T; Hamel E; Paull K D; Pommier Y
Azatoxin derivatives with potent and selective action on topoisomerase II.
Biochemical pharmacology 1995;49(9):1283-90.
1995: Goldwasser F; Bae I; Valenti M; Torres K; Pommier Y
Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.
Cancer research 1995;55(10):2116-21.
1995: Mazumder A; Raghavan K; Weinstein J; Kohn K W; Pommier Y
Inhibition of human immunodeficiency virus type-1 integrase by curcumin.
Biochemical pharmacology 1995;49(8):1165-70.
1995: Fujimori A; Harker W G; Kohlhagen G; Hoki Y; Pommier Y
Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin.
Cancer research 1995;55(6):1339-46.
1995: Raghavan K; Buolamwini J K; Fesen M R; Pommier Y; Kohn K W; Weinstein J N
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.
Journal of medicinal chemistry 1995;38(6):890-7.
1995: Shimizu T; O'Connor P M; Kohn K W; Pommier Y
Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage.
Cancer research 1995;55(2):228-31.
1995: Mazumder A; Gupta M; Perrin D M; Sigman D S; Rabinovitz M; Pommier Y
Inhibition of human immunodeficiency virus type 1 integrase by a hydrophobic cation: the phenanthroline-cuprous complex.
AIDS research and human retroviruses 1995;11(1):115-25.
1995: Kapoor R; Slade D L; Fujimori A; Pommier Y; Harker W G
Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin.
Oncology research 1995;7(2):83-95.
1994: Pommier Y; Poddevin B; Gupta M; Jenkins J
DNA topoisomerases I & II cleavage sites in the type 1 human immunodeficiency virus (HIV-1) DNA promoter region.
Biochemical and biophysical research communications 1994;205(3):1601-9.
1994: Leteurtre F; Fujimori A; Tanizawa A; Chhabra A; Mazumder A; Kohlhagen G; Nakano H; Pommier Y
Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions.
The Journal of biological chemistry 1994;269(46):28702-7.
1994: Mazumder A; Gupta M; Pommier Y
Methylphosphonodiester substitution near the conserved CA dinucleotide in the HIV LTR alters both extent of 3'-processing and choice of nucleophile by HIV-1 integrase.
Nucleic acids research 1994;22(21):4441-8.
1994: Leteurtre F; Kohlhagen G; Pommier Y
Streptonigrin-induced topoisomerase II sites exhibit base preferences in the middle of the enzyme stagger.
Biochemical and biophysical research communications 1994;203(2):1259-67.
1994: Leteurtre F; Kohlhagen G; Paull K D; Pommier Y
Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen.
Journal of the National Cancer Institute 1994;86(16):1239-44.
1994: Fesen M R; Pommier Y; Leteurtre F; Hiroguchi S; Yung J; Kohn K W
Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.
Biochemical pharmacology 1994;48(3):595-608.
1994: Solary E; Ling Y H; Perez-Soler R; Priebe W; Pommier Y
Hydroxyrubicin, a deaminated derivative of doxorubicin, inhibits mammalian DNA topoisomerase II and partially circumvents multidrug resistance.
International journal of cancer. Journal international du cancer 1994;58(1):85-94.
1994: Tanizawa A; Fujimori A; Fujimori Y; Pommier Y
Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials.
Journal of the National Cancer Institute 1994;86(11):836-42.
1994: Mazumder A; Cooney D; Agbaria R; Gupta M; Pommier Y
Inhibition of human immunodeficiency virus type 1 integrase by 3'-azido-3'-deoxythymidylate.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):5771-5.
1994: Solary E; Bertrand R; Pommier Y
Apoptosis of human leukemic HL-60 cells induced to differentiate by phorbol ester treatment.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(5):792-7.
1994: Leteurtre F; Kohlhagen G; Fesen M R; Tanizawa A; Kohn K W; Pommier Y
Effects of DNA methylation on topoisomerase I and II cleavage activities.
The Journal of biological chemistry 1994;269(11):7893-900.
1994: Pommier Y; Tanizawa A; Kohn K W
Mechanisms of topoisomerase I inhibition by anticancer drugs.
Advances in pharmacology (San Diego, Calif.) 1994;29B():73-92.
1994: Pommier Y; Leteurtre F; Fesen M R; Fujimori A; Bertrand R; Solary E; Kohlhagen G; Kohn K W
Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors.
Cancer investigation 1994;12(5):530-42.
1993: Tanizawa A; Beitrand R; Kohlhagen G; Tabuchi A; Jenkins J; Pommier Y
Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.
The Journal of biological chemistry 1993;268(34):25463-8.
1993: Tanizawa A; Kohn K W; Pommier Y
Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin.
Nucleic acids research 1993;21(22):5157-66.
1993: Poddevin B; Riou J F; Lavelle F; Pommier Y
Dual topoisomerase I and II inhibition by intoplicine (RP-60475), a new antitumor agent in early clinical trials.
Molecular pharmacology 1993;44(4):767-74.
1993: Kamesaki S; Kamesaki H; Jorgensen T J; Tanizawa A; Pommier Y; Cossman J
bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.
Cancer research 1993;53(18):4251-6.
1993: Leteurtre F; Fesen M; Kohlhagen G; Kohn K W; Pommier Y
Specific interaction of camptothecin, a topoisomerase I inhibitor, with guanine residues of DNA detected by photoactivation at 365 nm.
Biochemistry 1993;32(34):8955-62.
1993: Solary E; Leteurtre F; Paull K D; Scudiero D; Hamel E; Pommier Y
Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent.
Biochemical pharmacology 1993;45(12):2449-56.
1993: Fesen M R; Kohn K W; Leteurtre F; Pommier Y
Inhibitors of human immunodeficiency virus integrase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2399-403.
1993: Solary E; Bertrand R; Kohn K W; Pommier Y
Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors.
Blood 1993;81(5):1359-68.
1993: Capranico G; Tinelli S; Zunino F; Kohn K W; Pommier Y
Effects of base mutations on topoisomerase II DNA cleavage stimulated by mAMSA in short DNA oligomers.
Biochemistry 1993;32(1):145-52.
1993: Pommier Y
DNA topoisomerase I and II in cancer chemotherapy: update and perspectives.
Cancer chemotherapy and pharmacology 1993;32(2):103-8.
1992: Solary E; Bertrand R; Jenkins J; Pommier Y
Radiolabeling of DNA can induce its fragmentation in HL-60 human promyelocytic leukemic cells.
Experimental cell research 1992;203(2):495-8.
1992: Leteurtre F; Madalengoitia J; Orr A; Guzi T J; Lehnert E; Macdonald T; Pommier Y;
Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin.
Cancer research 1992;52(16):4478-83.
1992: Ding R; Pommier Y; Kang V H; Smulson M
Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.
The Journal of biological chemistry 1992;267(18):12804-12.
1992: Pommier Y; Orr A; Kohn K W; Riou J F
Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.
Cancer research 1992;52(11):3125-30.
1992: Tanizawa A; Pommier Y
Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture.
Cancer research 1992;52(7):1848-54.
1992: Bertrand R; O'Connor P M; Kerrigan D; Pommier Y
Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells.
European journal of cancer (Oxford, England : 1990) 1992;28A(4-5):743-8.
1991: Bertrand R; Sarang M; Jenkin J; Kerrigan D; Pommier Y
Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression.
Cancer research 1991;51(23 Pt 1):6280-5.
1991: Pommier Y; Capranico G; Orr A; Kohn K W
Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs.
Journal of molecular biology 1991;222(4):909-24.
1991: Pommier Y; Capranico G; Orr A; Kohn K W
Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.
Nucleic acids research 1991;19(21):5973-80.
1991: Jaxel C; Capranico G; Kerrigan D; Kohn K W; Pommier Y
Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.
The Journal of biological chemistry 1991;266(30):20418-23.
1991: O'Connor P M; Nieves-Neira W; Kerrigan D; Bertrand R; Goldman J; Kohn K W; Pommier Y
S-phase population analysis does not correlate with the cytotoxicity of camptothecin and 10,11-methylenedioxycamptothecin in human colon carcinoma HT-29 cells.
Cancer communications 1991;3(8):233-40.
1991: Bertrand R; Kerrigan D; Sarang M; Pommier Y
Cell death induced by topoisomerase inhibitors. Role of calcium in mammalian cells.
Biochemical pharmacology 1991;42(1):77-85.
1991: Pommier Y; Rünger T M; Kerrigan D; Kraemer K H
Relationship of DNA strand breakage produced by bromodeoxyuridine to topoisomerase II activity in Bloom-syndrome fibroblasts.
Mutation research 1991;254(2):185-90.
1990: Capranico G; Kohn K W; Pommier Y
Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.
Nucleic acids research 1990;18(22):6611-9.
1990: Capranico G; Jaxel C; Roberge M; Kohn K W; Pommier Y
Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin.
Nucleic acids research 1990;18(15):4553-9.
1990: Wassermann K; Markovits J; Jaxel C; Capranico G; Kohn K W; Pommier Y
Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II.
Molecular pharmacology 1990;38(1):38-45.
1990: Pommier Y; Kerrigan D; Hartman K D; Glazer R I
Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.
The Journal of biological chemistry 1990;265(16):9418-22.
1990: Capranico G; Zunino F; Kohn K W; Pommier Y
Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity.
Biochemistry 1990;29(2):562-9.
1990: Pommier Y; Cockerill P N; Kohn K W; Garrard W T
Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites.
Journal of virology 1990;64(1):419-23.
1990: Bhatia K; Pommier Y; Giri C; Fornace A J; Imaizumi M; Breitman T R; Cherney B W; Smulson M E
Expression of the poly(ADP-ribose) polymerase gene following natural and induced DNA strand breakage and effect of hyperexpression on DNA repair.
Carcinogenesis 1990;11(1):123-8.
1990: O'Connor P M; Kerrigan D; Bertrand R; Kohn K W; Pommier Y
10,11-Methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells.
Cancer communications 1990;2(12):395-400.
1990: Sinha B K; Politi P M; Eliot H M; Kerrigan D; Pommier Y
Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide.
European journal of cancer (Oxford, England : 1990) 1990;26(5):590-3.
1989: Holm C; Covey J M; Kerrigan D; Pommier Y
Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.
Cancer research 1989;49(22):6365-8.
1989: Covey J M; Jaxel C; Kohn K W; Pommier Y
Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.
Cancer research 1989;49(18):5016-22.
1989: Fesen M; Pommier Y
Mammalian topoisomerase II activity is modulated by the DNA minor groove binder distamycin in simian virus 40 DNA.
The Journal of biological chemistry 1989;264(19):11354-9.
1989: Jaxel C; Kohn K W; Wani M C; Wall M E; Pommier Y
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.
Cancer research 1989;49(6):1465-9.
1989: Pommier Y; Kerrigan D; Kohn K
Topological complexes between DNA and topoisomerase II and effects of polyamines.
Biochemistry 1989;28(3):995-1002.
1988: Jaxel C; Kohn K W; Pommier Y
Topoisomerase I interaction with SV40 DNA in the presence and absence of camptothecin.
Nucleic acids research 1988;16(23):11157-70.
1988: Sinha B K; Haim N; Dusre L; Kerrigan D; Pommier Y
DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action.
Cancer research 1988;48(18):5096-100.
1988: Covey J M; Kohn K W; Kerrigan D; Tilchen E J; Pommier Y
Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity.
Cancer research 1988;48(4):860-5.
1988: Pommier Y; Kerrigan D; Covey J M; Kao-Shan C S; Whang-Peng J
Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.
Cancer research 1988;48(3):512-6.
1987: Pommier Y; Covey J; Kerrigan D; Mattes W; Markovits J; Kohn K W
Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines.
Biochemical pharmacology 1987;36(20):3477-86.
1987: Pommier Y; Covey J M; Kerrigan D; Markovits J; Pham R
DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators.
Nucleic acids research 1987;15(16):6713-31.
1987: Markovits J; Pommier Y; Kerrigan D; Covey J M; Tilchen E J; Kohn K W
Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.
Cancer research 1987;47(8):2050-5.
1987: Kohn K W; Pommier Y; Kerrigan D; Markovits J; Covey J M
Topoisomerase II as a target of anticancer drug action in mammalian cells.
NCI monographs : a publication of the National Cancer Institute 1987;(4):61-71.

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