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Yves Pommier

Research Profile

Chemicals & Drugs

Disorders

DNA Damage

Concepts & Ideas

Anatomy

Living Beings

HIV-1

Procedures

Drug Screening Assays, Antitumor

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Publications

TOP 3
Yves Pommier
Drugging topoisomerases: lessons and challenges.
Mathieu Métifiot; Steven J Smith; Xue Zhi Zhao; Terrence R Burke; Peter Cherepanov; Stephen Hare; Stephen H Hughes; Barry C Johnson; Kasthuraiah Maddali; Christophe Marchand; Yves Pommier
Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.
Martin Conda-Sheridan; Keli Agama; Lakshman K Bindu; Adel Chergui; Brooklyn T Cobb; Christophe Marchand; Andrew Morrell; Yves Pommier; P V Narasimha Reddy; Amélie Renaud; Andrew G Stephen; Mark Cushman
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).

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All Publications

2013: Yves Pommier
Drugging topoisomerases: lessons and challenges.
ACS chemical biology 2013;8(1):82-95.
2013: Mathieu Métifiot; Steven J Smith; Xue Zhi Zhao; Terrence R Burke; Peter Cherepanov; Stephen Hare; Stephen H Hughes; Barry C Johnson; Kasthuraiah Maddali; Christophe Marchand; Yves Pommier
Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.
ACS chemical biology 2013;8(1):209-17.
2013: Martin Conda-Sheridan; Keli Agama; Lakshman K Bindu; Adel Chergui; Brooklyn T Cobb; Christophe Marchand; Andrew Morrell; Yves Pommier; P V Narasimha Reddy; Amélie Renaud; Andrew G Stephen; Mark Cushman
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
Journal of medicinal chemistry 2013;56(1):182-200.
2012: Maris A Cinelli; Keli Agama; Lian Chen; Jian-Hua Liang; Peng-Cheng Lv; Yves Pommier; P V Narasimha Reddy; Richard B Van Breemen; Mark Cushman
Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons.
Journal of medicinal chemistry 2012;55(24):10844-62.
2012: Xue Zhi Zhao; Stephen H Hughes; Barry C Johnson; Kasthuraiah Maddali; Christophe Marchand; Mathieu Métifiot; Yves Pommier; Steven J Smith; Terrence R Burke
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(24):7309-13.
2012: Yong-Wei Zhang; Arun K Ghosh; Yves Pommier
Lasonolide A, a potent and reversible inducer of chromosome condensation.
Cell cycle (Georgetown, Tex.) 2012;11(23):4424-35.
2012: Gabriele Zoppoli; Marie Regairaz; William C Reinhold; Sudhir Varma; Alberto Ballestrero; James H Doroshow; Elisabetta Leo; Yves Pommier
Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):15030-5.
2012: Rui Gao; Shar-yin N Huang; Christophe Marchand; Yves Pommier
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.
The Journal of biological chemistry 2012;287(36):30842-52.
2012: Stéphanie Solier; Jane Trepel; Wanping Xu; Kurt W Kohn; Leonard Neckers; Bradley Scroggins; Yves Pommier
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(32):12866-72.
2012: William C Reinhold; Margot Sunshine; Sudhir Varma; James Doroshow; Kurt W Kohn; Hongfang Liu; Joel Morris; Yves Pommier
CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.
Cancer research 2012;72(14):3499-511.
2012: Evgeny Kiselev; Yves Pommier; Keli Agama; Nicholas Empey; Mark Cushman
Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase I inhibitors: design, synthesis, and biological evaluation.
The Journal of organic chemistry 2012;77(11):5167-72.
2012: Trung Xuan Nguyen; Yves Pommier; Mark Cushman; Andrew G Stephen; Keli Agama; Alun Bermingam; Alun Bermingham; Adel Chergui; Martin Conda-Sheridan; Robert Fisher; Christophe Marchand; Andrew Morrell; Alena Naumova; Mark Cushman
Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
Journal of medicinal chemistry 2012;55(9):4457-78.
2012: Evgeny Kiselev; Yves Pommier; Keli Agama; Mark Cushman
Azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents: a systematic study of structure-activity relationships.
Journal of medicinal chemistry 2012;55(4):1682-97.
2012: Sheena M Aris; Yves Pommier
Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.
Cancer research 2012;72(4):979-89.
2012: Xue Zhi Zhao; Stephen H Hughes; Kasthuraiah Maddali; Christophe Marchand; Mathieu Metifiot; Yves Pommier; Steven J Smith; B Christie Vu; Terrence R Burke
Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
Chemical biology & drug design 2012;79(2):157-65.
2012: Thomas D Pfister; Yves Pommier; Howard Stotler; Joseph E Tomaszewski; Yiping Zhang; Suzanne D Borgel; John Carter; Raymond Divelbiss; Yvonne A Evrard; Melinda G Hollingshead; Jiuping Ji; Sonny A Khin; Robert Kinders; Shivaani Kummar; Ralph E Parchment; James H Doroshow
Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues.
PloS one 2012;7(12):e50494.
2012: Céline Douarre; Len Neckers; Benu Brata Das; Ilaria Dalla Rosa; Christophe E Redon; Carole Sourbier; Hongliang Zhang; Yves Pommier
Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.
PloS one 2012;7(7):e41094.
2012: Barry R Zeeberg; William C Reinhold; John N Weinstein; Ari Kahn; Kurt W Kohn; Vladimir Larionov; Yves Pommier
Concordance of gene expression and functional correlation patterns across the NCI-60 cell lines and the Cancer Genome Atlas glioblastoma samples.
PloS one 2012;7(7):e40062.
2012: Kurt W Kohn; Augustin Luna; William C Reinhold; Margot Sunshine; Barry R Zeeberg; Yves Pommier
Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processes.
PloS one 2012;7(5):e35716.
2012: Barry R Zeeberg; Kurt W Kohn; William C Reinhold; René Snajder; Gerhard G Thallinger; John N Weinstein; Yves Pommier
Functional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell lines.
PloS one 2012;7(1):e30317.
2011: George T Lountos; Yves Pommier; Christopher R Self; Robert H Shoemaker; Joseph E Tropea; Andrew G Jobson; Guangtao Zhang; David S Waugh
Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy.
Journal of structural biology 2011;176(3):292-301.
2011: Marie Regairaz; Nalini Tata; Yong-Wei Zhang; Keli Agama; Surbhi Agrawal; Mirit I Aladjem; Haiqing Fu; Yves Pommier
Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.
The Journal of cell biology 2011;195(5):739-49.
2011: Mathieu Métifiot; Steven Smith; Xue Zhi Zhao; Terrence Burke; Stephen Hughes; Barry Johnson; Christophe Marchand; Yves Pommier
MK-0536 inhibits HIV-1 integrases resistant to raltegravir.
Antimicrobial agents and chemotherapy 2011;55(11):5127-33.
2011: Melvenia M Martin; Paul S Meltzer; Yves Pommier; Mark Reimers; William C Reinhold; Michael Ryan; Manuel S Valenzuela; Anna L Zakas; Sven Bilke; Sean R Davis; James H Doroshow; Haiqing Fu; RyangGuk Kim; Chii Mei Lin; Hongfang Liu; Mirit I Aladjem
Genome-wide depletion of replication initiation events in highly transcribed regions.
Genome research 2011;21(11):1822-32.
2011: S E Martin; S Miyamoto; Yves Pommier; Z-H Wu; Y-W Zhang; Kristen S Gehlhaus; R Guha; T L Jones; Natasha J Caplen
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.
Current cancer drug targets 2011;11(8):976-86.
2011: Stephen Hare; Stephen H Hughes; Albert Jaxa-Chamiec; Mathieu Métifiot; Yves Pommier; Steven J Smith; Peter Cherepanov
Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).
Molecular pharmacology 2011;80(4):565-72.
2011: Victoria L Luchenko; Robert F Murphy; Yves Pommier; Crystal D Salcido; Keli Agama; Susan E Bates; Giuseppe Giaccone; Edina Komlodi-Pasztor; Yongwei Zhang; Lyuba Varticovski
Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancer.
Cell cycle (Georgetown, Tex.) 2011;10(18):3119-28.
2011: Evgeny Kiselev; Andrew Morrell; Yves Pommier; Keli Agama; Sean DeGuire; Thomas S Dexheimer; Mark Cushman
7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.
Journal of medicinal chemistry 2011;54(17):6106-16.
2011: Shar-yin N Huang; Yves Pommier; Christophe Marchand
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.
Expert opinion on therapeutic patents 2011;21(9):1285-92.
2011: Shivaani Kummar; Giovanni Melillo; Anthony J Murgo; Ralph E Parchment; Yves Pommier; Joel M Reid; Larry Rubinstein; Giovanna Speranza; Howard Stotler; Joseph E Tomaszewski; Lihua Wang; Marcie Weil; Yiping Zhang; Matthew Ames; William Bonner; John Carter; Alice Chen; Melinda G Hollingshead; Jiuping Ji; Lee Jia; Robert Kinders; James H Doroshow
Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas.
Cancer research 2011;71(17):5626-34.
2011: Dhriti Sooryakumar; Beverly A Teicher; Thomas S Dexheimer; Yves Pommier
Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.
Molecular cancer therapeutics 2011;10(8):1490-9.
2011: Gabriele Zoppoli; William Reinhold; Ilaria Dalla Rosa; Céline Douarre; Hongfang Liu; Yves Pommier
Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC.
Nucleic acids research 2011;39(15):6620-32.
2011: Katherine E Peterson; Yves Pommier; Thomas S Dexheimer; Akhil Mehta; Andrew Morrell; Keli Agama; Smitha Antony; Maris A Cinelli; Mark Cushman
Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.
Journal of medicinal chemistry 2011;54(14):4937-53.
2011: Mathieu Métifiot; Nick Vandegraaff; Kasthuraiah Maddali; Alena Naumova; Xuemin Zhang; David Rhodes; Christophe Marchand; Yves Pommier
Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143.
AIDS (London, England) 2011;25(9):1175-8.
2011: Xue Zhi Zhao; Kasthuraiah Maddali; Mathieu Metifiot; Steven J Smith; B Christie Vu; Christophe Marchand; Stephen H Hughes; Yves Pommier; Terrence R Burke
Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(10):2986-90.
2011: Yong-Wei Zhang; Marie Regairaz; Jennifer A Seiler; Keli Agama; James H Doroshow; Yves Pommier
Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.
Nucleic acids research 2011;39(9):3607-20.
2011: Antonio Ricci; Jessica Marinello; Marco Bortolus; Albert Sánchez; Anna Grandas; Enrique Pedroso; Yves Pommier; Giovanni Capranico; Anna Lisa Maniero; Giuseppe Zagotto
Electron paramagnetic resonance (EPR) study of spin-labeled camptothecin derivatives: a different look of the ternary complex.
Journal of medicinal chemistry 2011;54(4):1003-9.
2011: Patrick J Grohar; Laurie B Griffin; Choh Yeung; Qing-Rong Chen; Yves Pommier; Chand Khanna; Javed Khan; Lee Helman
Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.
Neoplasia (New York, N.Y.) 2011;13(2):145-53.
2011: Stéphanie Solier; Yves Pommier
MDC1 cleavage by caspase-3: a novel mechanism for inactivating the DNA damage response during apoptosis.
Cancer research 2011;71(3):906-13.
2011: William C Reinhold; Gabriele Zoppoli; Indri Erliandri; Hongfang Liu; Yves Pommier; Vladimir Larionov
Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability.
PloS one 2011;6(10):e25991.
2010: Evgeny Kiselev; Thomas S Dexheimer; Yves Pommier; Mark Cushman
Design, synthesis, and evaluation of dibenzo[c,h][1,6]naphthyridines as topoisomerase I inhibitors and potential anticancer agents.
Journal of medicinal chemistry 2010;53(24):8716-26.
2010: William H Gmeiner; William C Reinhold; Yves Pommier
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Molecular cancer therapeutics 2010;9(12):3105-14.
2010: Benu Brata Das; Thomas S Dexheimer; Kasthuraiah Maddali; Yves Pommier
Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19790-5.
2010: Robert Kinders; Melinda G Hollingshead; Scott Lawrence; Jiuping Ji; Brian Tabb; William M Bonner; Yves Pommier; Larry Rubinstein; Yvonne A Evrard; Ralph E Parchment; Joseph Tomaszewski; James Doroshow
Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(22):5447-57.
2010: Christophe E Redon; Asako J Nakamura; Yong-Wei Zhang; Jiuping Jay Ji; William M Bonner; Robert Kinders; Ralph E Parchment; James Doroshow; Yves Pommier
Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(18):4532-42.
2010: Maris A Cinelli; Andrew E Morrell; Thomas S Dexheimer; Keli Agama; Surbhi Agrawal; Yves Pommier; Mark Cushman
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
Bioorganic & medicinal chemistry 2010;18(15):5535-52.
2010: Chenzhong Liao; Christophe Marchand; Terrence R Burke; Yves Pommier; Marc C Nicklaus
Authentic HIV-1 integrase inhibitors.
Future medicinal chemistry 2010;2(7):1107-22.
2010: Jinesh Gheeya; Peter Johansson; Qing-Rong Chen; Thomas Dexheimer; Belhu Metaferia; Young K Song; Jun S Wei; Jianbin He; Yves Pommier; Javed Khan
Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor.
Cancer letters 2010;293(1):124-31.
2010: Mathieu Métifiot; Kasthuraiah Maddali; Christophe Marchand; Yves Pommier
Resistance to integrase inhibitors.
Viruses 2010;2(7):1347-66.
2010: Chiara Conti; Elisabetta Leo; Gabriel S Eichler; Olivier Sordet; Melvenia M Martin; Angela Fan; Mirit I Aladjem; Yves Pommier
Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage.
Cancer research 2010;70(11):4470-80.
2010: Yves Pommier; Elisabetta Leo; HongLiang Zhang; Christophe Marchand
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.
Chemistry & biology 2010;17(5):421-33.
2010: Mathieu Métifiot; Kasthuraiah Maddali; Alena Naumova; Xuemin Zhang; Christophe Marchand; Yves Pommier
Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir.
Biochemistry 2010;49(17):3715-22.
2010: Hongfang Liu; Petula D'Andrade; Stephanie Fulmer-Smentek; Philip L Lorenzi; Kurt W Kohn; John N Weinstein; Yves Pommier; William C Reinhold
mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities.
Molecular cancer therapeutics 2010;9(5):1080-91.
2010: Thomas S Dexheimer; Andrew G Stephen; Matthew J Fivash; Robert J Fisher; Yves Pommier
The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.
Nucleic acids research 2010;38(7):2444-52.
2010: William C Reinhold; Jean-Louis Mergny; Hongfang Liu; Michael Ryan; Thomas D Pfister; Robert Kinders; Ralph Parchment; James Doroshow; John N Weinstein; Yves Pommier
Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron.
Cancer research 2010;70(6):2191-203.
2010: Yunlong Song; Zhiyu Shao; Thomas S Dexheimer; Evan S Scher; Yves Pommier; Mark Cushman
Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors.
Journal of medicinal chemistry 2010;53(5):1979-89.
2010: Asako J Nakamura; V Ashutosh Rao; Yves Pommier; William M Bonner
The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks.
Cell cycle (Georgetown, Tex.) 2010;9(2):389-97.
2010: Olivier Sordet; Asako J Nakamura; Christophe E Redon; Yves Pommier
DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions.
Cell cycle (Georgetown, Tex.) 2010;9(2):274-8.
2010: Iwona E Weidlich; Thomas Dexheimer; Christophe Marchand; Smitha Antony; Yves Pommier; Marc C Nicklaus
Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.
Bioorganic & medicinal chemistry 2010;18(1):182-9.
2009: Benu Brata Das; Smitha Antony; Shalu Gupta; Thomas S Dexheimer; Christophe E Redon; Susan Garfield; Yosef Shiloh; Yves Pommier
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
The EMBO journal 2009;28(23):3667-80.
2009: Andrew G Jobson; George T Lountos; Philip L Lorenzi; Jenny Llamas; John Connelly; David Cerna; Joseph E Tropea; Akikazu Onda; Gabriele Zoppoli; Sudhir Kondapaka; Guangtao Zhang; Natasha J Caplen; John H Cardellina; Stephen S Yoo; Anne Monks; Christopher Self; David S Waugh; Robert H Shoemaker; Yves Pommier
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].
The Journal of pharmacology and experimental therapeutics 2009;331(3):816-26.
2009: Thomas S Dexheimer; Lalji Gediya; Andrew G Stephen; Iwona Weidlich; Smitha Antony; Christophe Marchand; Heidrun Interthal; Marc C Nicklaus; Robert J Fisher; Vincent Njar; Yves Pommier
4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
Journal of medicinal chemistry 2009;52(22):7122-31.
2009: Maris A Cinelli; Brenda Cordero; Thomas S Dexheimer; Yves Pommier; Mark Cushman
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
Bioorganic & medicinal chemistry 2009;17(20):7145-55.
2009: Olivier Sordet; Christophe E Redon; Josée Guirouilh-Barbat; Susan Smith; Stéphanie Solier; Céline Douarre; Chiara Conti; Asako J Nakamura; Benu B Das; Estelle Nicolas; Kurt W Kohn; William M Bonner; Yves Pommier
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
EMBO reports 2009;10(8):887-93.
2009: Kurt W Kohn; Mirit I Aladjem; John N Weinstein; Yves Pommier
Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.
Cell cycle (Georgetown, Tex.) 2009;8(14):2281-99.
2009: Xue Zhi Zhao; Kasthuraiah Maddali; Christophe Marchand; Yves Pommier; Terrence R Burke
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.
Bioorganic & medicinal chemistry 2009;17(14):5318-24.
2009: Josée Guirouilh-Barbat; Smitha Antony; Yves Pommier
Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.
Molecular cancer therapeutics 2009;8(7):2007-14.
2009: Josée Guirouilh-Barbat; Yong-Wei Zhang; Yves Pommier
Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin.
Molecular cancer therapeutics 2009;8(7):1985-94.
2009: Thomas D Pfister; William C Reinhold; Keli Agama; Shalu Gupta; Sonny A Khin; Robert Kinders; Ralph E Parchment; Joseph E Tomaszewski; James Doroshow; Yves Pommier
Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity.
Molecular cancer therapeutics 2009;8(7):1878-84.
2009: Josiah N Orina; Anna Maria Calcagno; Chung-Pu Wu; Sudhir Varma; Joanna Shih; Min Lin; Gabriel Eichler; John N Weinstein; Yves Pommier; Suresh V Ambudkar; Michael M Gottesman; Jean-Pierre Gillet
Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database.
Molecular cancer therapeutics 2009;8(7):2057-66.
2009: Yves Pommier
DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition.
Chemical reviews 2009;109(7):2894-902.
2009: Stéphanie Solier; Yves Pommier
The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases.
Cell cycle (Georgetown, Tex.) 2009;8(12):1853-9.
2009: Xue Zhi Zhao; Kasthuraiah Maddali; B Christie Vu; Christophe Marchand; Stephen H Hughes; Yves Pommier; Terrence R Burke
Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.
Bioorganic & medicinal chemistry letters 2009;19(10):2714-7.
2009: Yves Pommier; Mark Cushman
The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives.
Molecular cancer therapeutics 2009;8(5):1008-14.
2009: Christophe Marchand; Kasthuraiah Maddali; Mathieu Métifiot; Yves Pommier
HIV-1 IN inhibitors: 2010 update and perspectives.
Current topics in medicinal chemistry 2009;9(11):1016-37.
2009: Uma Shankavaram; Sudhir Varma; David Kane; Margot Sunshine; Krishna K Chary; William C Reinhold; Yves Pommier; John N Weinstein
CellMiner: a relational database and query tool for the NCI-60 cancer cell lines.
BMC genomics 2009;10():277.
2009: George T Lountos; Joseph E Tropea; Di Zhang; Andrew G Jobson; Yves Pommier; Robert H Shoemaker; David S Waugh
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor.
Protein science : a publication of the Protein Society 2009;18(1):92-100.
2008: William M Bonner; Christophe E Redon; Jennifer S Dickey; Asako J Nakamura; Olga A Sedelnikova; Stéphanie Solier; Yves Pommier
GammaH2AX and cancer.
Nature reviews. Cancer 2008;8(12):957-67.
2008: Gregory J Aune; Kazutaka Takagi; Olivier Sordet; Josée Guirouilh-Barbat; Smitha Antony; Vilhelm A Bohr; Yves Pommier
Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6449-55.
2008: Jessica Marinello; Christophe Marchand; Bryan T Mott; Anjali Bain; Craig J Thomas; Yves Pommier
Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants.
Biochemistry 2008;47(36):9345-54.
2008: Olivier Sordet; Stéphane Larochelle; Estelle Nicolas; Ellen V Stevens; Chao Zhang; Kevan M Shokat; Robert P Fisher; Yves Pommier
Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.
Journal of molecular biology 2008;381(3):540-9.
2008: Josée Guirouilh-Barbat; Christophe Redon; Yves Pommier
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
Molecular biology of the cell 2008;19(9):3969-81.
2008: Olivier Sordet; Abby Goldman; Christophe Redon; Stéphanie Solier; V Ashutosh Rao; Yves Pommier
Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.
The Journal of biological chemistry 2008;283(34):23200-8.
2008: Thomas S Dexheimer; Albena Kozekova; Carmelo J Rizzo; Michael P Stone; Yves Pommier
The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts.
Nucleic acids research 2008;36(12):4128-36.
2008: Thomas S Dexheimer; Smitha Antony; Christophe Marchand; Yves Pommier
Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
Anti-cancer agents in medicinal chemistry 2008;8(4):381-9.
2008: Ling-Hua Meng; Zhaojing Meng; Ze-Hong Miao; Timothy D Veenstra; Yves Pommier
Cytokeratin-RNA cross-linking mediated by the antitumor aminoflavone, 5-amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one.
The Journal of pharmacology and experimental therapeutics 2008;325(2):674-80.
2008: Gary S Laco; Yves Pommier
Role of a tryptophan anchor in human topoisomerase I structure, function and inhibition.
The Biochemical journal 2008;411(3):523-30.
2008: Lancelot McLean; Ubaldo Soto; Keli Agama; Jawad Francis; Randi Jimenez; Yves Pommier; Lawrence C Sowers; Eileen Brantley
Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells.
International journal of cancer. Journal international du cancer 2008;122(7):1665-74.
2008: Zhiyong Liao; Robert W Robey; Josée Guirouilh-Barbat; Kenneth K W To; Orsolya Polgar; Susan E Bates; Yves Pommier
Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.
Molecular pharmacology 2008;73(2):490-7.
2008: Tsutomu Shimura; Michael J Torres; Melvenia M Martin; V Ashutosh Rao; Yves Pommier; Mari Katsura; Kiyoshi Miyagawa; Mirit I Aladjem
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Journal of molecular biology 2008;375(4):1152-64.
2008: Thomas S Dexheimer; Yves Pommier
DNA cleavage assay for the identification of topoisomerase I inhibitors.
Nature protocols 2008;3(11):1736-50.
2008: Ellen V Stevens; Satoshi Nishizuka; Smitha Antony; Mark Reimers; Sudhir Varma; Lynn Young; Peter J Munson; John N Weinstein; Elise C Kohn; Yves Pommier
Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers.
Molecular cancer therapeutics 2008;7(1):10-8.
2008: Elena A Semenova; Christophe Marchand; Yves Pommier
HIV-1 integrase inhibitors: update and perspectives.
Advances in pharmacology (San Diego, Calif.) 2008;56():199-228.
2008: Christophe Marchand; John A Beutler; Antony Wamiru; Scott Budihas; Ute Möllmann; Lothar Heinisch; John W Mellors; Stuart F J Le Grice; Yves Pommier
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.
Antimicrobial agents and chemotherapy 2008;52(1):361-4.
2008: Kurt W Kohn; Mirit I Aladjem; John N Weinstein; Yves Pommier
Chromatin challenges during DNA replication: a systems representation.
Molecular biology of the cell 2008;19(1):1-7.
2007: Kazutaka Takagi; Thomas S Dexheimer; Christophe Redon; Olivier Sordet; Keli Agama; Gilbert Lavielle; Alain Pierré; Susan E Bates; Yves Pommier
Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.
Molecular cancer therapeutics 2007;6(12 Pt 1):3229-38.
2007: Chiara Conti; Jennifer A Seiler; Yves Pommier
The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses.
Cell cycle (Georgetown, Tex.) 2007;6(22):2760-7.
2007: Smitha Antony; Keli Agama; Ze-Hong Miao; Kazutaka Takagi; Mollie H Wright; Ana I Robles; Lyuba Varticovski; Muthukaman Nagarajan; Andrew Morrell; Mark Cushman; Yves Pommier
Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.
Cancer research 2007;67(21):10397-405.
2007: V Ashutosh Rao; Keli Agama; Susan Holbeck; Yves Pommier
Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
Cancer research 2007;67(20):9971-9.
2007: Ming Zhou; Zhaojing Meng; Andrew G Jobson; Yves Pommier; Timothy D Veenstra
Detection of in vitro kinase generated protein phosphorylation sites using gamma[18O4]-ATP and mass spectrometry.
Analytical chemistry 2007;79(20):7603-10.
2007: Chenzhong Liao; Rajeshri G Karki; Christophe Marchand; Yves Pommier; Marc C Nicklaus
Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.
Bioorganic & medicinal chemistry letters 2007;17(19):5361-5.
2007: Andrew G Jobson; John H Cardellina; Dominic A Scudiero; Sudhir B Kondapaka; Hongliang Zhang; Hijoo Kim; Robert Shoemaker; Yves Pommier
Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.
Molecular pharmacology 2007;72(4):876-84.
2007: Ze-Hong Miao; Audrey Player; Uma Shankavaram; Yong-Hong Wang; Drazen Zimonjic; Philip L Lorenzi; Zhi-Yong Liao; Hong Liu; Tsutomu Shimura; Hong-Liang Zhang; Ling-Hua Meng; Yong-Wei Zhang; Ernest S Kawasaki; Nicholas C Popescu; Mirit I Aladjem; David J Goldstein; John N Weinstein; Yves Pommier
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses.
Cancer research 2007;67(18):8752-61.
2007: Andrew Morrell; Michael Placzek; Seth Parmley; Smitha Antony; Thomas S Dexheimer; Yves Pommier; Mark Cushman
Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.
Journal of medicinal chemistry 2007;50(18):4419-30.
2007: Andrew Morrell; Michael Placzek; Seth Parmley; Brian Grella; Smitha Antony; Yves Pommier; Mark Cushman
Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors.
Journal of medicinal chemistry 2007;50(18):4388-404.
2007: Yonghong Wang; Ze-Hong Miao; Yves Pommier; Ernest S Kawasaki; Audrey Player
Characterization of mismatch and high-signal intensity probes associated with Affymetrix genechips.
Bioinformatics (Oxford, England) 2007;23(16):2088-95.
2007: Jennifer A Seiler; Chiara Conti; Ali Syed; Mirit I Aladjem; Yves Pommier
The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses.
Molecular and cellular biology 2007;27(16):5806-18.
2007: Ling-Hua Meng; Kurt W Kohn; Yves Pommier
Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).
Oncogene 2007;26(33):4806-16.
2007: V Ashutosh Rao; Chiara Conti; Josee Guirouilh-Barbat; Asako Nakamura; Ze-Hong Miao; Sally L Davies; Barbara Saccá; Ian D Hickson; Aaron Bensimon; Yves Pommier
Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.
Molecular cancer research : MCR 2007;5(7):713-24.
2007: Andrew Morrell; Michael Placzek; Jamin D Steffen; Smitha Antony; Keli Agama; Yves Pommier; Mark Cushman
Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures.
Journal of medicinal chemistry 2007;50(9):2040-8.
2007: Yves Pommier
Finding the interface: more than an image.
Cancer biology & therapy 2007;6(4):620-3.
2007: Hongliang Zhang; Ling-Hua Meng; Yves Pommier
Mitochondrial topoisomerases and alternative splicing of the human TOP1mt gene.
Biochimie 2007;89(4):474-81.
2007: Elvira E Shults; Elena A Semenova; Allison A Johnson; Svetlana P Bondarenko; Irina Yu Bagryanskaya; Yuri V Gatilov; Genrikh A Tolstikov; Yves Pommier
Synthesis and HIV-1 integrase inhibitory activity of spiroundecane(ene) derivatives.
Bioorganic & medicinal chemistry letters 2007;17(5):1362-8.
2007: Allison A Johnson; Christophe Marchand; Sachindra Patil; Roberta Costi; Roberto Di Santo; Terrence R Burke; Yves Pommier
Probing HIV-1 integrase inhibitor binding sites with position-specific integrase-DNA cross-linking assays.
Molecular pharmacology 2007;71(3):893-901.
2007: William C Reinhold; Mark Reimers; Alika K Maunakea; Sohyoung Kim; Samir Lababidi; Uwe Scherf; Uma Shankavaram; Micah S Ziegler; Claudia Stewart; Hosein Kouros-Mehr; Hengmi Cui; Douglas Dolginow; Dominic A Scudiero; Yves Pommier; David J Munroe; Andrew P Feinberg; John N Weinstein
Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells.
Molecular cancer therapeutics 2007;6(2):391-403.
2007: Smitha Antony; Christophe Marchand; Andrew G Stephen; Laurent Thibaut; Keli Agama; Robert J Fisher; Yves Pommier
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1.
Nucleic acids research 2007;35(13):4474-84.
2006: Andrew Morrell; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Mark Cushman
A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.
Journal of medicinal chemistry 2006;49(26):7740-53.
2006: Ze-Hong Miao; Keli Agama; Olivier Sordet; Lawrence F Povirk; Kurt W Kohn; Yves Pommier
Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.
DNA repair 2006;5(12):1489-94.
2006: Olivier Sordet; Abby Goldman; Yves Pommier
Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes.
Molecular cancer therapeutics 2006;5(12):3139-44.
2006: Allison A Johnson; Jane M Sayer; Haruhiko Yagi; Sachindra Patil; Françoise Debart; Martin A Maier; David R Corey; Jean-Jacques Vasseur; Terrence R Burke; Victor E Marquez; Donald M Jerina; Yves Pommier
Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
The Journal of biological chemistry 2006;281(43):32428-38.
2006: Muthukaman Nagarajan; Andrew Morrell; Alexandra Ioanoviciu; Smitha Antony; Glenda Kohlhagen; Keli Agama; Melinda G Hollingshead; Yves Pommier; Mark Cushman
Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles.
Journal of medicinal chemistry 2006;49(21):6283-9.
2006: Haruyuki Takemura; V Ashutosh Rao; Olivier Sordet; Takahisa Furuta; Ze-Hong Miao; Linghua Meng; Hongliang Zhang; Yves Pommier
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
The Journal of biological chemistry 2006;281(41):30814-23.
2006: Ling-Hua Meng; Uma Shankavaram; Chi Chen; Keli Agama; Hai-qing Fu; Frank J Gonzalez; John Weinstein; Yves Pommier
Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.
Cancer research 2006;66(19):9656-64.
2006: Yves Pommier
Topoisomerase I inhibitors: camptothecins and beyond.
Nature reviews. Cancer 2006;6(10):789-802.
2006: Raghuram S Tangirala; Smitha Antony; Keli Agama; Yves Pommier; Bradley D Anderson; Robert Bevins; Dennis P Curran
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin.
Bioorganic & medicinal chemistry 2006;14(18):6202-12.
2006: Elena A Semenova; Allison A Johnson; Christophe Marchand; Yves Pommier
Integration of human immunodeficiency virus as a target for antiretroviral therapy.
Current opinion in HIV and AIDS 2006;1(5):380-7.
2006: Smitha Antony; Keli Agama; Ze-Hong Miao; Melinda G Hollingshead; Susan Holbeck; Mollie H Wright; Lyuba Varticovski; Muthukaman Nagarajan; Andrew Morrell; Mark Cushman; Yves Pommier
Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.
Molecular pharmacology 2006;70(3):1109-20.
2006: Chi Chen; Linghua Meng; Xiaochao Ma; Kristopher W Krausz; Yves Pommier; Jeffrey R Idle; Frank J Gonzalez
Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).
The Journal of pharmacology and experimental therapeutics 2006;318(3):1330-42.
2006: Muthukaman Nagarajan; Andrew Morrell; Smitha Antony; Glenda Kohlhagen; Keli Agama; Yves Pommier; Patricia A Ragazzon; Nichola C Garbett; Jonathan B Chaires; Melinda G Hollingshead; Mark Cushman
Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.
Journal of medicinal chemistry 2006;49(17):5129-40.
2006: Andrew Morrell; Muthusamy Jayaraman; Muthukaman Nagarajan; Brian M Fox; Marintha Rae Meckley; Alexandra Ioanoviciu; Yves Pommier; Smitha Antony; Melinda G Hollingshead; Mark Cushman
Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.
Bioorganic & medicinal chemistry letters 2006;16(16):4395-9.
2006: Ze-Hong Miao; V Ashutosh Rao; Keli Agama; Smitha Antony; Kurt W Kohn; Yves Pommier
4-nitroquinoline-1-oxide induces the formation of cellular topoisomerase I-DNA cleavage complexes.
Cancer research 2006;66(13):6540-5.
2006: Yuli Kim; Yunguang Sun; Carson Chow; Yves Pommier; S Stoney Simons
Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation.
The Journal of steroid biochemistry and molecular biology 2006;100(1-3):3-17.
2006: Zhiyong Liao; Laurent Thibaut; Andrew Jobson; Yves Pommier
Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.
Molecular pharmacology 2006;70(1):366-72.
2006: Eileen Brantley; Smitha Antony; Glenda Kohlhagen; Linghua Meng; Keli Agama; Sherman F Stinson; Edward A Sausville; Yves Pommier
Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells.
Cancer chemotherapy and pharmacology 2006;58(1):62-72.
2006: Jinxia Deng; James A Kelley; Joseph J Barchi; Tino Sanchez; Raveendra Dayam; Yves Pommier; Nouri Neamati
Mining the NCI antiviral compounds for HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry 2006;14(11):3785-92.
2006: Takahisa Furuta; R L Hayward; Ling-Hua Meng; Haruyuki Takemura; Gregory J Aune; William M Bonner; Mirit I Aladjem; Kurt W Kohn; Yves Pommier
p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
Oncogene 2006;25(20):2839-49.
2006: Yves Pommier; John N Weinstein; Mirit I Aladjem; Kurt W Kohn
Chk2 molecular interaction map and rationale for Chk2 inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2657-61.
2006: Andrew Morrell; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Mark Cushman
Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(7):1846-9.
2006: Elena A Semenova; Allison A Johnson; Christophe Marchand; David A Davis; Robert Yarchoan; Yves Pommier
Preferential inhibition of the magnesium-dependent strand transfer reaction of HIV-1 integrase by alpha-hydroxytropolones.
Molecular pharmacology 2006;69(4):1454-60.
2006: Xiangshu Xiao; Smitha Antony; Yves Pommier; Mark Cushman
Total synthesis and biological evaluation of 22-hydroxyacuminatine.
Journal of medicinal chemistry 2006;49(4):1408-12.
2006: Christophe Marchand; Smitha Antony; Kurt W Kohn; Mark Cushman; Alexandra Ioanoviciu; Bart L Staker; Alex B Burgin; Lance Stewart; Yves Pommier
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.
Molecular cancer therapeutics 2006;5(2):287-95.
2006: Allison A Johnson; Webster Santos; Godwin C G Pais; Christophe Marchand; Ronak Amin; Terrence R Burke; Gregory L Verdine; Yves Pommier
Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop.
The Journal of biological chemistry 2006;281(1):461-7.
2006: Kurt W Kohn; Mirit I Aladjem; Sohyoung Kim; John N Weinstein; Yves Pommier
Depicting combinatorial complexity with the molecular interaction map notation.
Molecular systems biology 2006;2():51.
2006: Christophe Marchand; Krzysztof Krajewski; Hsiu-Fang Lee; Smitha Antony; Allison A Johnson; Ronak Amin; Peter P Roller; Mamuka Kvaratskhelia; Yves Pommier
Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites.
Nucleic acids research 2006;34(18):5157-65.
2006: Yves Pommier; Juana M Barcelo; V Ashutosh Rao; Olivier Sordet; Andrew G Jobson; Laurent Thibaut; Ze-Hong Miao; Jennifer A Seiler; Hongliang Zhang; Christophe Marchand; Keli Agama; John L. Nitiss; Christophe Redon
Repair of topoisomerase I-mediated DNA damage.
Progress in nucleic acid research and molecular biology 2006;81():179-229.
2006: Kurt W Kohn; Mirit I Aladjem; John N Weinstein; Yves Pommier
Molecular interaction maps of bioregulatory networks: a general rubric for systems biology.
Molecular biology of the cell 2006;17(1):1-13.
2005: Raghuram S Tangirala; Rachel Dixon; Danzhou Yang; Attila Ambrus; Smitha Antony; Keli Agama; Yves Pommier; Dennis P Curran
Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin.
Bioorganic & medicinal chemistry letters 2005;15(21):4736-40.
2005: V Ashutosh Rao; Angela M Fan; Linghua Meng; Christopher F Doe; Phillip S North; Ian D Hickson; Yves Pommier
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Molecular and cellular biology 2005;25(20):8925-37.
2005: Alexandra Ioanoviciu; Smitha Antony; Yves Pommier; Bart L Staker; Lance Stewart; Mark Cushman
Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.
Journal of medicinal chemistry 2005;48(15):4803-14.
2005: Yves Pommier; Christophe Marchand
Interfacial inhibitors of protein-nucleic acid interactions.
Current medicinal chemistry. Anti-cancer agents 2005;5(4):421-9.
2005: Ling-Hua Meng; Glenda Kohlhagen; Zhi-Yong Liao; Smitha Antony; Edward A Sausville; Yves Pommier
DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells.
Cancer research 2005;65(12):5337-43.
2005: Kurt W Kohn; Yves Pommier
Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage.
Biochemical and biophysical research communications 2005;331(3):816-27.
2005: Xiangshu Xiao; Ze-Hong Miao; Smitha Antony; Yves Pommier; Mark Cushman
Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines.
Bioorganic & medicinal chemistry letters 2005;15(11):2795-8.
2005: Zhi-Yong Liao; Olivier Sordet; Hong-Liang Zhang; Glenda Kohlhagen; Smitha Antony; William H Gmeiner; Yves Pommier
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Cancer research 2005;65(11):4844-51.
2005: Xiangshu Xiao; Smitha Antony; Yves Pommier; Mark Cushman
On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex.
Journal of medicinal chemistry 2005;48(9):3231-8.
2005: Bart L Staker; Michael D Feese; Mark Cushman; Yves Pommier; David Zembower; Lance Stewart; Alex B Burgin
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Journal of medicinal chemistry 2005;48(7):2336-45.
2005: Paola B Arimondo; Gary S Laco; Craig J Thomas; Ludovic Halby; Didier Pez; Philippe Schmitt; Alexandre S Boutorine; Thérèse Garestier; Yves Pommier; Sidney Hecht; Jian-Sheng Sun; Christian Bailly
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides.
Biochemistry 2005;44(11):4171-80.
2005: Yves Pommier; Jacqueline Cherfils
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery.
Trends in pharmacological sciences 2005;26(3):138-45.
2005: Yves Pommier; Allison A Johnson; Christophe Marchand
Integrase inhibitors to treat HIV/AIDS.
Nature reviews. Drug discovery 2005;4(3):236-48.
2005: Smitha Antony; Glenda Kohlhagen; Keli Agama; Muthusamy Jayaraman; Shousong Cao; Farukh A Durrani; Youcef M Rustum; Mark Cushman; Yves Pommier
Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison.
Molecular pharmacology 2005;67(2):523-30.
2005: Yves Pommier; Olivier Sordet; V Ashutosh Rao; Hongliang Zhang; Kurt W Kohn
Targeting chk2 kinase: molecular interaction maps and therapeutic rationale.
Current pharmaceutical design 2005;11(22):2855-72.
2004: Ling-Hua Meng; Hongliang Zhang; Larry Hayward; Haruyuki Takemura; Rong-Guang Shao; Yves Pommier
Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.
Cancer research 2004;64(24):9086-92.
2004: Donghui Yu; Ehsan Khan; Md Abdul Khaleque; James Lee; Gary S Laco; Glenda Kohlhagen; Surender Kharbanda; Yung-Chi Cheng; Yves Pommier; Ajit Bharti
Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity.
The Journal of biological chemistry 2004;279(50):51851-61.
2004: Jean-Philippe Annereau; Gergely Szakács; Charles J Tucker; Angela Arciello; Carol Cardarelli; Jennifer Collins; Sherry F Grissom; Barry R Zeeberg; William C Reinhold; John N Weinstein; Yves Pommier; Richard S Paules; Michael M Gottesman
Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.
Molecular pharmacology 2004;66(6):1397-405.
2004: Olivier Sordet; Qasim A Khan; Isabelle Plo; Philippe Pourquier; Yoshimasa Urasaki; Akira Yoshida; Smitha Antony; Glenda Kohlhagen; Eric Solary; Murat Saparbaev; Jacques Laval; Yves Pommier
Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.
The Journal of biological chemistry 2004;279(48):50499-504.
2004: Krzysztof Krajewski; Christophe Marchand; Ya-Qiu Long; Yves Pommier; Peter P Roller
Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.
Bioorganic & medicinal chemistry letters 2004;14(22):5595-8.
2004: Muthukaman Nagarajan; Andrew Morrell; Brian C Fort; Marintha Rae Meckley; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Mark Cushman
Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.
Journal of medicinal chemistry 2004;47(23):5651-61.
2004: Xiangshu Xiao; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Mark Cushman
Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline.
The Journal of organic chemistry 2004;69(22):7495-501.
2004: Gary S Laco; Wu Du; Glenda Kohlhagen; Jane M Sayer; Donald M Jerina; Thomas G Burke; Dennis P Curran; Yves Pommier
Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies.
Bioorganic & medicinal chemistry 2004;12(19):5225-35.
2004: Xiangshu Xiao; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Mark Cushman
Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors.
Bioorganic & medicinal chemistry 2004;12(19):5147-60.
2004: Yves Pommier
Camptothecins and topoisomerase I: a foot in the door. Targeting the genome beyond topoisomerase I with camptothecins and novel anticancer drugs: importance of DNA replication, repair and cell cycle checkpoints.
Current medicinal chemistry. Anti-cancer agents 2004;4(5):429-34.
2004: Olivier Sordet; Qasim A Khan; Yves Pommier
Apoptotic topoisomerase I-DNA complexes induced by oxygen radicals and mitochondrial dysfunction.
Cell cycle (Georgetown, Tex.) 2004;3(9):1095-7.
2004: Nicholas Farrell; Lawrence F Povirk; Yojana Dange; Gerald A DeMasters; Mona S Gupta; Glenda Kohlhagen; Qasim A Khan; Yves Pommier; David Gewirtz
Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells.
Biochemical pharmacology 2004;68(5):857-66.
2004: Olivier Sordet; ZhiYong Liao; Hong Liu; Smitha Antony; Ellen V Stevens; Glenda Kohlhagen; Haiqing Fu; Yves Pommier
Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis.
The Journal of biological chemistry 2004;279(32):33968-75.
2004: Susan E Bates; Wilma Y Medina-Pérez; Glenda Kohlhagen; Smitha Antony; Tim Nadjem; Robert W Robey; Yves Pommier
ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins.
The Journal of pharmacology and experimental therapeutics 2004;310(2):836-42.
2004: Andrew Morrell; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Mark Cushman
Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(14):3659-63.
2004: Susan D Mertins; Timothy G Myers; Susan Holbeck; Wilma Medina-Perez; Elaine Wang; Glenda Kohlhagen; Yves Pommier; Susan E Bates
In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity.
Molecular cancer therapeutics 2004;3(7):849-60.
2004: Kurt W Kohn; Joseph Riss; Olga Aprelikova; John N Weinstein; Yves Pommier; J Carl Barrett
Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system.
Molecular biology of the cell 2004;15(7):3042-52.
2004: Jill E Chrencik; Bart L Staker; Alex B Burgin; Philippe Pourquier; Yves Pommier; Lance Stewart; Matthew R Redinbo
Mechanisms of camptothecin resistance by human topoisomerase I mutations.
Journal of molecular biology 2004;339(4):773-84.
2004: Rong-Guang Shao; Chun-Xia Cao; Yves Pommier
Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
Acta pharmacologica Sinica 2004;25(6):756-62.
2004: Laurent Candeil; Isabelle Gourdier; Delphine Peyron; Nadia Vezzio; Virginie Copois; Frédéric Bibeau; Béatrice Orsetti; George L Scheffer; Marc Ychou; Qasim A Khan; Yves Pommier; Bernard Pau; Pierre Martineau; Maguy Del Rio
ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases.
International journal of cancer. Journal international du cancer 2004;109(6):848-54.
2004: Yves Pommier; Olivier Sordet; Smitha Antony; Richard L Hayward; Kurt W Kohn
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks.
Oncogene 2004;23(16):2934-49.
2004: Evguenia S Svarovskaia; Rebekah Barr; Xuechun Zhang; Godwin C G Pais; Christophe Marchand; Yves Pommier; Terrence R Burke; Vinay K Pathak
Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions.
Journal of virology 2004;78(7):3210-22.
2004: Xuechun Zhang; Christophe Marchand; Yves Pommier; Terrence R Burke
Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.
Bioorganic & medicinal chemistry letters 2004;14(5):1205-7.
2004: Mirit I Aladjem; Stefania Pasa; Stefano Parodi; John N Weinstein; Yves Pommier; Kurt W Kohn
Molecular interaction maps--a diagrammatic graphical language for bioregulatory networks.
Science's STKE : signal transduction knowledge environment 2004;2004(222):pe8.
2004: Allison A Johnson; Jane M Sayer; Haruhiko Yagi; Govind P Kalena; Ronak Amin; Donald M Jerina; Yves Pommier
Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates.
The Journal of biological chemistry 2004;279(9):7947-55.
2004: Annamaria Rapisarda; Badarch Uranchimeg; Olivier Sordet; Yves Pommier; Robert H Shoemaker; Giovanni Melillo
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.
Cancer research 2004;64(4):1475-82.
2004: Smitha Antony; Jacob A Theruvathu; Philip J Brooks; Diem-Thu Lesher; Matt Redinbo; Yves Pommier
Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine.
Nucleic acids research 2004;32(18):5685-92.
2004: Smitha Antony; Paola B Arimondo; Jian-Sheng Sun; Yves Pommier
Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures.
Nucleic acids research 2004;32(17):5163-73.
2004: Allison A Johnson; Christophe Marchand; Yves Pommier
HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial.
Current topics in medicinal chemistry 2004;4(10):1059-77.
2004: Hongliang Zhang; Ling-Hua Meng; Drazen Zimonjic; Nicholas C Popescu; Yves Pommier
Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases.
Nucleic acids research 2004;32(7):2087-92.
2003: Muthukaman Nagarajan; Xiangshu Xiao; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Mark Cushman
Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.
Journal of medicinal chemistry 2003;46(26):5712-24.
2003: Yves Pommier; Christophe Redon; V Ashutosh Rao; Jennifer A Seiler; Olivier Sordet; Haruyuki Takemura; Smitha Antony; LingHua Meng; ZhiYong Liao; Glenda Kohlhagen; HongLiang Zhang; Kurt W Kohn
Repair of and checkpoint response to topoisomerase I-mediated DNA damage.
Mutation research 2003;532(1-2):173-203.
2003: Smitha Antony; Muthusamy Jayaraman; Gary S Laco; Glenda Kohlhagen; Kurt W Kohn; Mark Cushman; Yves Pommier
Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.
Cancer research 2003;63(21):7428-35.
2003: Myoung Sook Kim; Mellissa Blake; Jin Hyen Baek; Glenda Kohlhagen; Yves Pommier; France Carrier
Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA.
Cancer research 2003;63(21):7291-300.
2003: Qasim A Khan; Glenda Kohlhagen; Richard Marshall; Caroline A Austin; Govind P Kalena; Heiko Kroth; Jane M Sayer; Donald M Jerina; Yves Pommier
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12498-503.
2003: Isabelle Plo; Zhi-Yong Liao; Juana M Barceló; Glenda Kohlhagen; Keith W Caldecott; Michael Weinfeld; Yves Pommier
Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions.
DNA repair 2003;2(10):1087-100.
2003: Krzysztof Krajewski; Ya-Qiu Long; Christophe Marchand; Yves Pommier; Peter P Roller
Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.
Bioorganic & medicinal chemistry letters 2003;13(19):3203-5.
2003: John N Weinstein; Yves Pommier
Transcriptomic analysis of the NCI-60 cancer cell lines.
Comptes rendus biologies 2003;326(10-11):909-20.
2003: Akira Yoshida; Yoshimasa Urasaki; Mark Waltham; Ann-Charlotte Bergman; Philippe Pourquier; Dominic G Rothwell; Manabu Inuzuka; John N Weinstein; Takanori Ueda; Ettore Appella; Ian D Hickson; Yves Pommier
Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis.
The Journal of biological chemistry 2003;278(39):37768-76.
2003: Christophe Marchand; Allison A Johnson; Rajeshri G Karki; Godwin C G Pais; Xuechun Zhang; Kiriana Cowansage; Tapan A Patel; Marc C Nicklaus; Terrence R Burke; Yves Pommier
Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).
Molecular pharmacology 2003;64(3):600-9.
2003: Brian M Fox; Xiangshu Xiao; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Bart L Staker; Lance Stewart; Mark Cushman
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
Journal of medicinal chemistry 2003;46(15):3275-82.
2003: Olivier Sordet; Qasim A Khan; Kurt W Kohn; Yves Pommier
Apoptosis induced by topoisomerase inhibitors.
Current medicinal chemistry. Anti-cancer agents 2003;3(4):271-90.
2003: Takahisa Furuta; Haruyuki Takemura; Zhi-Yong Liao; Gregory J Aune; Christophe Redon; Olga A Sedelnikova; Duane R Pilch; Emmy P Rogakou; Arkady Celeste; Hua-Tang Chen; André Nussenzweig; Mirit I Aladjem; William M Bonner; Yves Pommier
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
The Journal of biological chemistry 2003;278(22):20303-12.
2003: William H Gmeiner; Shuyuan Yu; Richard T Pon; Philippe Pourquier; Yves Pommier
Structural basis for topoisomerase I inhibition by nucleoside analogs.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):653-8.
2003: Jill E Chrencik; Alex B Burgin; Yves Pommier; Lance Stewart; Matthew R Redinbo
Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex.
The Journal of biological chemistry 2003;278(14):12461-6.
2003: Xuechun Zhang; Godwin C G Pais; Evguenia S Svarovskaia; Christophe Marchand; Allison A Johnson; Rajeshri G Karki; Marc C Nicklaus; Vinay K Pathak; Yves Pommier; Terrence R Burke
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(6):1215-9.
2003: William C Reinhold; Hosein Kouros-Mehr; Kurt W Kohn; Alika K Maunakea; Samir Lababidi; Anna V Roschke; Kristen Stover; Jes Alexander; Panayotis Pantazis; Lance Miller; Edison Liu; Ilan R Kirsch; Yoshimasa Urasaki; Yves Pommier; John N Weinstein
Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping.
Cancer research 2003;63(5):1000-11.
2003: Ling-Hua Meng; Zhi-Yong Liao; Yves Pommier
Non-camptothecin DNA topoisomerase I inhibitors in cancer therapy.
Current topics in medicinal chemistry 2003;3(3):305-20.
2002: Nouri Neamati; Zhaiwei Lin; Rajeshri G Karki; Ann H Orr; Kiriana Cowansage; Dirk Strumberg; Godwin C G Pais; Johannes H Voigt; Marc C Nicklaus; Heather E Winslow; He Zhao; Jim A Turpin; Jizu Yi; Anna Marie Skalka; Terrence R Burke; Yves Pommier
Metal-dependent inhibition of HIV-1 integrase.
Journal of medicinal chemistry 2002;45(26):5661-70.
2002: Qiang Yu; JiHyun La Rose; Hongliang Zhang; Haruyuki Takemura; Kurt W Kohn; Yves Pommier
UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
Cancer research 2002;62(20):5743-8.
2002: Isabelle Gourdier; Maguy Del Rio; Laure Crabbé; Laurent Candeil; Virginie Copois; Marc Ychou; Charles Auffray; Pierre Martineau; Nadir Mechti; Yves Pommier; Bernard Pau
Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma.
FEBS letters 2002;529(2-3):232-6.
2002: Takahisa Furuta; Takahiro Ueda; Gregory J Aune; Alain Sarasin; Kenneth H Kraemer; Yves Pommier
Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells.
Cancer research 2002;62(17):4899-902.
2002: Isabelle Plo; Hélène Hernandez; Glenda Kohlhagen; Dominique Lautier; Yves Pommier; Guy Laurent
Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells.
The Journal of biological chemistry 2002;277(35):31407-15.
2002: Philippe Pourquier; Christopher Gioffre; Glenda Kohlhagen; Yoshimasa Urasaki; François Goldwasser; Lary W Hertel; Shuyuan Yu; Richard T Pon; William H Gmeiner; Yves Pommier
Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2499-504.
2002: Guozhang Xu; Arunachalam Kannan; Tracy L Hartman; Heather Wargo; Karen Watson; Jim A Turpin; Robert W Buckheit; Allison A Johnson; Yves Pommier; Mark Cushman
Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents.
Bioorganic & medicinal chemistry 2002;10(8):2807-16.
2002: Godwin C G Pais; Xuechun Zhang; Christophe Marchand; Nouri Neamati; Kiriana Cowansage; Evguenia S Svarovskaia; Vinay K Pathak; Yun Tang; Marc C Nicklaus; Yves Pommier; Terrence R Burke
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 2002;45(15):3184-94.
2002: Gregory J Aune; Takahisa Furuta; Yves Pommier
Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action.
Anti-cancer drugs 2002;13(6):545-55.
2002: Yves Pommier; Glenda Kohlhagen; Gary S Laco; Heiko Kroth; Jane M Sayer; Donald M Jerina
Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site.
The Journal of biological chemistry 2002;277(16):13666-72.
2002: Christophe Marchand; Xuechun Zhang; Godwin C G Pais; Kiriana Cowansage; Nouri Neamati; Terrence R Burke; Yves Pommier
Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.
The Journal of biological chemistry 2002;277(15):12596-603.
2002: Yi Zhou; Fuad G Gwadry; William C Reinhold; Lance D Miller; Lawrence H Smith; Uwe Scherf; Edison Liu; Kurt W Kohn; Yves Pommier; John N Weinstein
Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects.
Cancer research 2002;62(6):1688-95.
2002: Christophe Marchand; Philippe Pourquier; Gary S Laco; Naijie Jing; Yves Pommier
Interaction of human nuclear topoisomerase I with guanosine quartet-forming and guanosine-rich single-stranded DNA and RNA oligonucleotides.
The Journal of biological chemistry 2002;277(11):8906-11.
2002: Gary S Laco; Jack R Collins; Brian T Luke; Heiko Kroth; Jane M Sayer; Donald M Jerina; Yves Pommier
Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model.
Biochemistry 2002;41(5):1428-35.
2002: Meni Melek; Jessica M Jones; Mary H O'Dea; Godwin C G Pais; Terrence R Burke; Yves Pommier; Nouri Neamati; Martin Gellert
Effect of HIV integrase inhibitors on the RAG1/2 recombinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):134-7.
2002: Muthusamy Jayaraman; Brian M Fox; Melinda G Hollingshead; Glenda Kohlhagen; Yves Pommier; Mark Cushman
Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model.
Journal of medicinal chemistry 2002;45(1):242-9.
2001: Y Fan; Leming Shi; Kurt W Kohn; Yves Pommier; John N Weinstein
Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies.
Journal of medicinal chemistry 2001;44(20):3254-63.
2001: Hongliang Zhang; J M Barceló; Byungkook Lee; Glenda Kohlhagen; Drazen Zimonjic; Nicholas C Popescu; Yves Pommier
Human mitochondrial topoisomerase I.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10608-13.
2001: Q Yu; J H Rose; Hongliang Zhang; Yves Pommier
Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells.
FEBS letters 2001;505(1):7-12.
2001: Y Takebayashi; Philippe Pourquier; Drazen Zimonjic; K Nakayama; Steffen Emmert; Takahiro Ueda; Yoshimasa Urasaki; A Kanzaki; S I Akiyama; N Popescu; Kenneth H Kraemer; Yves Pommier
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.
Nature medicine 2001;7(8):961-6.
2001: Xuechun Zhang; N Neamati; Y K Lee; A Orr; R D Brown; N Whitaker; Yves Pommier; Terrence R Burke
Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase.
Bioorganic & medicinal chemistry 2001;9(7):1649-57.
2001: Rong-Guang Shao; Chun-Xia Cao; W Nieves-Neira; M T Dimanche-Boitrel; Eric Solary; Yves Pommier
Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells.
Oncogene 2001;20(15):1852-9.
2001: Yoshimasa Urasaki; Gary S Laco; Philippe Pourquier; Y Takebayashi; Glenda Kohlhagen; Christopher Gioffre; Hongliang Zhang; D Chatterjee; P Pantazis; Yves Pommier
Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.
Cancer research 2001;61(5):1964-9.
2001: Yoshimasa Urasaki; Gary S Laco; Y Takebayashi; Christian Bailly; Glenda Kohlhagen; Yves Pommier
Use of camptothecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site.
Cancer research 2001;61(2):504-8.
2001: Christophe Marchand; Nouri Neamati; Yves Pommier
In vitro human immunodeficiency virus type 1 integrase assays.
Methods in enzymology 2001;340():624-33.
2001: Y Takebayashi; F Goldwasser; Yoshimasa Urasaki; Glenda Kohlhagen; Yves Pommier
Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(1):185-91.
2001: Philippe Pourquier; J L Waltman; Yoshimasa Urasaki; N A Loktionova; A E Pegg; John L. Nitiss; Yves Pommier
Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.
Cancer research 2001;61(1):53-8.
2001: Philippe Pourquier; Yves Pommier
Topoisomerase I-mediated DNA damage.
Advances in cancer research 2001;80():189-216.
2000: Yoshimasa Urasaki; Y Takebayashi; Yves Pommier
Activity of a novel camptothecin analogue, homocamptothecin, in camptothecin-resistant cell lines with topoisomerase I alterations.
Cancer research 2000;60(23):6577-80.
2000: David Bom; Dennis P Curran; S Kruszewski; Stephen G Zimmer; J Thompson Strode; Glenda Kohlhagen; Wu Du; A J Chavan; K A Fraley; Alexander Bingcang; Lori J Latus; Yves Pommier; Thomas G Burke
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.
Journal of medicinal chemistry 2000;43(21):3970-80.
2000: Mark Cushman; Muthusamy Jayaraman; JA Vroman; A K Fukunaga; Brian M Fox; Glenda Kohlhagen; D Strumberg; Yves Pommier
Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.
Journal of medicinal chemistry 2000;43(20):3688-98.
2000: I-Jen Chen; Nouri Neamati; Marc C Nicklaus; Ann H Orr; L Anderson; Joseph J Barchi; James A Kelley; Yves Pommier; Alexander D. Mackerell
Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets.
Bioorganic & medicinal chemistry 2000;8(10):2385-98.
2000: Yves Pommier; Gary S Laco; Glenda Kohlhagen; Jane M Sayer; Heiko Kroth; Donald M Jerina
Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10739-44.
2000: Andre A Pilon; Christophe Marchand; Mark F Kavlick; K Bajaj; J Owen; Hiroaki Mitsuya; Yves Pommier
Mutations in the HIV type 1 integrase of patients receiving long-term dideoxynucleoside therapy do not confer resistance to zidovudine.
AIDS research and human retroviruses 2000;16(14):1417-22.
2000: Yves Pommier; Christophe Marchand; Nouri Neamati
Retroviral integrase inhibitors year 2000: update and perspectives.
Antiviral research 2000;47(3):139-48.
2000: Dirk Strumberg; Andre A Pilon; M Smith; Robert Hickey; Linda H Malkas; Yves Pommier
Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff.
Molecular and cellular biology 2000;20(11):3977-87.
2000: Jolanta Fertala; John R Vance; Philippe Pourquier; Yves Pommier; Mary-Ann Bjornsti
Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.
The Journal of biological chemistry 2000;275(20):15246-53.
2000: Emmy P Rogakou; W Nieves-Neira; C Boon; Yves Pommier; William M Bonner
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.
The Journal of biological chemistry 2000;275(13):9390-5.
2000: Uwe Scherf; Douglas T Ross; Mark Waltham; Lawrence H Smith; Jae K Lee; Lorraine Tanabe; Kurt W Kohn; William C Reinhold; Timothy G Myers; D T Andrews; Dominic A Scudiero; Michael B Eisen; Edward A Sausville; Yves Pommier; David Botstein; Patrick O Brown; John N Weinstein
A gene expression database for the molecular pharmacology of cancer.
Nature genetics 2000;24(3):236-44.
2000: Yves Pommier; Glenda Kohlhagen; Philippe Pourquier; Jane M Sayer; Heiko Kroth; Donald M Jerina
Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2040-5.
2000: Philippe Pourquier; Y Takebayashi; Yoshimasa Urasaki; Christopher Gioffre; Glenda Kohlhagen; Yves Pommier
Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1885-90.
2000: Kurt W Kohn; Rong-Guang Shao; Yves Pommier
How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?
Cell biochemistry and biophysics 2000;33(2):175-80.
2000: Kurt W Kohn; Yves Pommier
Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors.
Annals of the New York Academy of Sciences 2000;922():11-26.
2000: Nouri Neamati; Christophe Marchand; Yves Pommier
HIV-1 integrase inhibitors: past, present, and future.
Advances in pharmacology (San Diego, Calif.) 2000;49():147-65.
1999: M Brangi; Thomas Litman; Marco Ciotti; K Nishiyama; Glenda Kohlhagen; Chris H Takimoto; Robert W Robey; Yves Pommier; Tito Fojo; Susan E Bates
Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.
Cancer research 1999;59(23):5938-46.
1999: Yun-Xing Wang; Nouri Neamati; Jaison Jacob; I Palmer; Stephen J Stahl; Joshua D Kaufman; PL Huang; P L Huang; Heather E Winslow; Yves Pommier; Paul T Wingfield; S Lee-Huang; Adriaan Bax; Dennis A Torchia
Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions.
Cell 1999;99(4):433-42.
1999: Dirk Strumberg; John L. Nitiss; J Dong; Kurt W Kohn; Yves Pommier
Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.
The Journal of biological chemistry 1999;274(40):28246-55.
1999: W Nieves-Neira; M I Rivera; Glenda Kohlhagen; M L Hursey; Philippe Pourquier; Edward A Sausville; Yves Pommier
DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells.
Molecular pharmacology 1999;56(3):478-84.
1999: Nouri Neamati; Jim A Turpin; Heather E Winslow; JL Christensen; K Williamson; Ann H Orr; William G Rice; Yves Pommier; Antonio Garofalo; Antonella Brizzi; Giuseppe Campiani; Isabella Fiorini; Vito Nacci
Thiazolothiazepine inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1999;42(17):3334-41.
1999: W Nieves-Neira; Yves Pommier
Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways.
International journal of cancer. Journal international du cancer 1999;82(3):396-404.
1999: F Goldwasser; I Bae; Yves Pommier; Albert J Fornace
Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation.
Anticancer research 1999;19(4B):3167-71.
1999: Y Takebayashi; Philippe Pourquier; Akira Yoshida; Glenda Kohlhagen; Yves Pommier
Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7196-201.
1999: Z Lin; Nouri Neamati; Hong Zhao; Y Kiryu; Jim A Turpin; Claudia Aberham; Klaus Strebel; Kurt W Kohn; M Witvrouw; C Pannecouque; zeger debyser; E De Clercq; William G Rice; Yves Pommier; Terrence R Burke
Chicoric acid analogues as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 1999;42(8):1401-14.
1999: Philippe Pourquier; A D Jensen; S S Gong; Yves Pommier; Charles E Rogler
Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro.
Nucleic acids research 1999;27(8):1919-25.
1999: Philippe Pourquier; L M Ueng; Jolanta Fertala; D Wang; H J Park; J M Essigmann; Mary-Ann Bjornsti; Yves Pommier
Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine.
The Journal of biological chemistry 1999;274(13):8516-23.
1999: Dirk Strumberg; John L. Nitiss; A Rose; Marc C Nicklaus; Yves Pommier
Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.
The Journal of biological chemistry 1999;274(11):7292-301.
1999: Rong-Guang Shao; Chun-Xia Cao; Hongliang Zhang; Kurt W Kohn; M S Wold; Yves Pommier
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
The EMBO journal 1999;18(5):1397-406.
1999: France Carrier; Philippe Georgel; Philippe Pourquier; Mellissa Blake; H Udo Kontny; Michael J Antinore; M Gariboldi; Timothy G Myers; John N Weinstein; Yves Pommier; Albert J Fornace
Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.
Molecular and cellular biology 1999;19(3):1673-85.
1999: D Strumberg; Yves Pommier; KD Paull; Muthusamy Jayaraman; P Nagafuji; Mark Cushman
Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
Journal of medicinal chemistry 1999;42(3):446-57.
1999: Han-Mo Koo; M Gray-Goodrich; Glenda Kohlhagen; Mary Jane McWilliams; M Jeffers; A Vaigro-Wolff; W G Alvord; Anne Monks; KD Paull; Yves Pommier; George Vande Woude
The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis.
Journal of the National Cancer Institute 1999;91(3):236-44.
1999: Philippe Pourquier; Glenda Kohlhagen; L M Ueng; Yves Pommier
Topoisomerase I and II Activity Assays.
Methods in molecular medicine 1999;28():95-110.
1999: Yves Pommier; Nouri Neamati
Inhibitors of human immunodeficiency virus integrase.
Advances in virus research 1999;52():427-58.
1998: Philippe Pourquier; Yves Pommier
[Topoisomerases I: new targets for the treatment of cancer and mechanisms of resistance].
Bulletin du cancer 1998;Spec No():5-10.
1998: W Hiraoka; N Vazquez; W Nieves-Neira; STEPHEN CHANOCK; Yves Pommier
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.
The Journal of clinical investigation 1998;102(11):1961-8.
1998: H Hong; Nouri Neamati; Heather E Winslow; JL Christensen; Ann H Orr; Yves Pommier; GW Milne
Identification of HIV-1 integrase inhibitors based on a four-point pharmacophore.
Antiviral chemistry & chemotherapy 1998;9(6):461-72.
1998: Philippe Pourquier; Mary-Ann Bjornsti; Yves Pommier
Induction of topoisomerase I cleavage complexes by the vinyl chloride adduct 1,N6-ethenoadenine.
The Journal of biological chemistry 1998;273(42):27245-9.
1998: Yves Pommier; Philippe Pourquier; Y Fan; Dirk Strumberg
Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme.
Biochimica et biophysica acta 1998;1400(1-3):83-105.
1998: Nouri Neamati; H Hong; J M Owen; S Sunder; Heather E Winslow; JL Christensen; Hong Zhao; Terrence R Burke; GW Milne; Yves Pommier
Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.
Journal of medicinal chemistry 1998;41(17):3202-9.
1998: Nouri Neamati; A Mazumder; S Sunder; J M Owen; M Tandon; J William Lown; Yves Pommier
Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase.
Molecular pharmacology 1998;54(2):280-90.
1998: Glenda Kohlhagen; KD Paull; Mark Cushman; P Nagafuji; Yves Pommier
Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.
Molecular pharmacology 1998;54(1):50-8.
1998: Y Fan; John N Weinstein; Kurt W Kohn; Leming Shi; Yves Pommier
Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.
Journal of medicinal chemistry 1998;41(13):2216-26.
1998: Akira Yoshida; Philippe Pourquier; Yves Pommier
Purification and characterization of a Mg2+-dependent endonuclease (AN34) from etoposide-treated human leukemia HL-60 cells undergoing apoptosis.
Cancer research 1998;58(12):2576-82.
1998: T Shimizu; Chun-Xia Cao; Rong-Guang Shao; Yves Pommier
Lamin B phosphorylation by protein kinase calpha and proteolysis during apoptosis in human leukemia HL60 cells.
The Journal of biological chemistry 1998;273(15):8669-74.
1998: Yves Pommier; Glenda Kohlhagen; C Wu; D T Simmons
Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen.
Biochemistry 1998;37(11):3818-23.
1998: Yves Pommier
Diversity of DNA topoisomerases I and inhibitors.
Biochimie 1998;80(3):255-70.
1998: B W Parker; G Kaur; W Nieves-Neira; M Taimi; Glenda Kohlhagen; T Shimizu; M D Losiewicz; Yves Pommier; Edward A Sausville; A M Senderowicz
Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol.
Blood 1998;91(2):458-65.
1997: Rong-Guang Shao; Chun-Xia Cao; Yves Pommier
Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells.
The Journal of biological chemistry 1997;272(50):31321-5.
1997: Nouri Neamati; H Hong; S Sunder; GW Milne; Yves Pommier
Potent inhibitors of human immunodeficiency virus type 1 integrase: identification of a novel four-point pharmacophore and tetracyclines as novel inhibitors.
Molecular pharmacology 1997;52(6):1041-55.
1997: Philippe Pourquier; Andre A Pilon; Glenda Kohlhagen; A Mazumder; A Sharma; Yves Pommier
Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects.
The Journal of biological chemistry 1997;272(42):26441-7.
1997: C Pondarré; Dirk Strumberg; Akira Fujimori; R Torres-León; Yves Pommier
In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells.
Nucleic acids research 1997;25(20):4111-6.
1997: Rong-Guang Shao; Chun-Xia Cao; T Shimizu; Patrick M O'Connor; Kurt W Kohn; Yves Pommier
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
Cancer research 1997;57(18):4029-35.
1997: A Mazumder; Nouri Neamati; S Sunder; J Schulz; Heinz H Pertz; Eckart Eich; Yves Pommier
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.
Journal of medicinal chemistry 1997;40(19):3057-63.
1997: M Gupta; S Fan; Qimin Zhan; Kurt W Kohn; Patrick M O'Connor; Yves Pommier
Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(9):1653-60.
1997: T Shimizu; Yves Pommier
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases.
Leukemia 1997;11(8):1238-44.
1997: Rong-Guang Shao; T Shimizu; Yves Pommier
7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
Experimental cell research 1997;234(2):388-97.
1997: M Valenti; W Nieves-Neira; Glenda Kohlhagen; Kurt W Kohn; Monroe E Wall; Mansukh C Wani; Yves Pommier
Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells.
Molecular pharmacology 1997;52(1):82-7.
1997: A Y Chen; P Okunieff; Yves Pommier; James B Mitchell
Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives.
Cancer research 1997;57(8):1529-36.
1997: Hong Zhao; Nouri Neamati; A Mazumder; S Sunder; Yves Pommier; Terrence R Burke
Arylamide inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1997;40(8):1186-94.
1997: A Mazumder; H Uchida; Nouri Neamati; S Sunder; M Jaworska-Maslanka; Eric Wickstrom; F Zeng; R A Jones; R F Mandes; H K Chenault; Yves Pommier
Probing interactions between viral DNA and human immunodeficiency virus type 1 integrase using dinucleotides.
Molecular pharmacology 1997;51(4):567-75.
1997: Philippe Pourquier; L M Ueng; Glenda Kohlhagen; A Mazumder; M Gupta; Kurt W Kohn; Yves Pommier
Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.
The Journal of biological chemistry 1997;272(12):7792-6.
1997: Nouri Neamati; H Hong; A Mazumder; Shulin Wang; S Sunder; Marc C Nicklaus; GW Milne; B Proksa; Yves Pommier
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
Journal of medicinal chemistry 1997;40(6):942-51.
1997: Hong Zhao; Nouri Neamati; S Sunder; H Hong; Shulin Wang; GW Milne; Yves Pommier; Terrence R Burke
Hydrazide-containing inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1997;40(6):937-41.
1997: H Hong; Nouri Neamati; Shulin Wang; Marc C Nicklaus; A Mazumder; Hong Zhao; Terrence R Burke; Yves Pommier; GW Milne
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
Journal of medicinal chemistry 1997;40(6):930-6.
1997: Marc C Nicklaus; Nouri Neamati; H Hong; A Mazumder; S Sunder; J Chen; GW Milne; Yves Pommier
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.
Journal of medicinal chemistry 1997;40(6):920-9.
1997: Nouri Neamati; A Mazumder; Hong Zhao; S Sunder; Terrence R Burke; R J Schultz; Yves Pommier
Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.
Antimicrobial agents and chemotherapy 1997;41(2):385-93.
1997: Hong Zhao; Nouri Neamati; H Hong; A Mazumder; Shulin Wang; S Sunder; GW Milne; Yves Pommier; Terrence R Burke
Coumarin-based inhibitors of HIV integrase.
Journal of medicinal chemistry 1997;40(2):242-9.
1997: Yuko Hoki; Akira Fujimori; Yves Pommier
Differential cytotoxicity of clinically important camptothecin derivatives in P-glycoprotein-overexpressing cell lines.
Cancer chemotherapy and pharmacology 1997;40(5):433-8.
1996: F Goldwasser; T Shimizu; Yves Pommier
Failure in DNA elongation predicts sensitivity to camptothecin in the colon cell lines of the NCI Anticancer Drug Screen.
Annals of the New York Academy of Sciences 1996;803():308-9.
1996: Yves Pommier; M Gupta; M Valenti; W Nieves-Neira
Cellular resistance to camptothecins.
Annals of the New York Academy of Sciences 1996;803():60-73.
1996: J K Buolamwini; K Raghavan; M R Fesen; Yves Pommier; Kurt W Kohn; J N Weinstein
Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.
Pharmaceutical research 1996;13(12):1892-5.
1996: Akira Fujimori; M Gupta; Yuko Hoki; Yves Pommier
Acquired camptothecin resistance of human breast cancer MCF-7/C4 cells with normal topoisomerase I and elevated DNA repair.
Molecular pharmacology 1996;50(6):1472-8.
1996: A Mazumder; Nouri Neamati; Andre A Pilon; S Sunder; Yves Pommier
Chemical trapping of ternary complexes of human immunodeficiency virus type 1 integrase, divalent metal, and DNA substrates containing an abasic site. Implications for the role of lysine 136 in DNA binding.
The Journal of biological chemistry 1996;271(44):27330-8.
1996: A Mazumder; Nouri Neamati; JO Ojwang; S Sunder; RF Rando; Yves Pommier
Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures.
Biochemistry 1996;35(43):13762-71.
1996: Yves Pommier; Glenda Kohlhagen; C Bailly; M Waring; A Mazumder; Kurt W Kohn
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.
Biochemistry 1996;35(41):13303-9.
1996: F Goldwasser; T Shimizu; J Jackman; Yuko Hoki; Patrick M O'Connor; Kurt W Kohn; Yves Pommier
Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.
Cancer research 1996;56(19):4430-7.
1996: Rong-Guang Shao; T Shimizu; Yves Pommier
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.
Experimental cell research 1996;227(2):190-6.
1996: T Shimizu; Yves Pommier
DNA fragmentation induced by protease activation in p53-null human leukemia HL60 cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: cell-free system studies.
Experimental cell research 1996;226(2):292-301.
1996: A Mazumder; Shulin Wang; Nouri Neamati; Marc C Nicklaus; S Sunder; J Chen; GW Milne; William G Rice; Terrence R Burke; Yves Pommier
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
Journal of medicinal chemistry 1996;39(13):2472-81.
1996: F Goldwasser; M Valenti; R Torres; Kurt W Kohn; Yves Pommier
Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(4):687-93.
1996: A Mazumder; Nouri Neamati; J P Sommadossi; G Gosselin; Ray F Schinazi; J L Imbach; Yves Pommier
Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase.
Molecular pharmacology 1996;49(4):621-8.
1996: Eric Solary; L Dubrez; Béatrice Eymin; R Bertrand; Yves Pommier
[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors].
Bulletin du cancer 1996;83(3):205-12.
1996: Yves Pommier
Eukaryotic DNA topoisomerase I: genome gatekeeper and its intruders, camptothecins.
Seminars in oncology 1996;23(1 Suppl 3):3-10.
1996: Eckart Eich; Heinz H Pertz; M Kaloga; J Schulz; M R Fesen; A Mazumder; Yves Pommier
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
Journal of medicinal chemistry 1996;39(1):86-95.
1996: F Goldwasser; I Bae; Albert J Fornace; Yves Pommier
Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines.
Oncology research 1996;8(7-8):317-23.
1996: Akira Fujimori; Yuko Hoki; N C Popescu; Yves Pommier
Silencing and selective methylation of the normal topoisomerase I gene in camptothecin-resistant CEM/C2 human leukemia cells.
Oncology research 1996;8(7-8):295-301.
1995: A Mazumder; Arnona Gazit; A Levitzki; Marc C Nicklaus; J Yung; Glenda Kohlhagen; Yves Pommier
Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.
Biochemistry 1995;34(46):15111-22.
1995: JO Ojwang; Robert W Buckheit; Yves Pommier; A Mazumder; K De Vreese; José A Esté; D Reymen; Luke A Pallansch; C Lackman-Smith; Tom Wallace
T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1995;39(11):2426-35.
1995: Terrence R Burke; M R Fesen; A Mazumder; J Wang; A M Carothers; D Grunberger; J Driscoll; Kurt W Kohn; Yves Pommier
Hydroxylated aromatic inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1995;38(21):4171-8.
1995: Béatrice Eymin; Eric Solary; Sylvie Chevillard; L Dubrez; F Goldwasser; O Duchamp; P Genne; F Leteurtre; Yves Pommier
Cellular pharmacology of azatoxins (topoisomerase-II and tubulin inhibitors) in P-glycoprotein-positive and -negative cell lines.
International journal of cancer. Journal international du cancer 1995;63(2):268-75.
1995: M Gupta; M Abdel-Megeed; Yuko Hoki; Glenda Kohlhagen; KD Paull; Yves Pommier
Eukaryotic DNA topoisomerases mediated DNA cleavage induced by a new inhibitor: NSC 665517.
Molecular pharmacology 1995;48(4):658-65.
1995: Yves Pommier; Glenda Kohlhagen; Kurt W Kohn; F Leteurtre; M C Wani; M E Wall
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8861-5.
1995: Yves Pommier; J Jenkins; Glenda Kohlhagen; F Leteurtre
DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors.
Mutation research 1995;337(2):135-45.
1995: Mary E Hawkins; W Pfleiderer; A Mazumder; Yves Pommier; FRANK BALIS
Incorporation of a fluorescent guanosine analog into oligonucleotides and its application to a real time assay for the HIV-1 integrase 3'-processing reaction.
Nucleic acids research 1995;23(15):2872-80.
1995: A Mazumder; Yves Pommier
Processing of deoxyuridine mismatches and abasic sites by human immunodeficiency virus type-1 integrase.
Nucleic acids research 1995;23(15):2865-71.
1995: L Dubrez; F Goldwasser; P Genne; Yves Pommier; Eric Solary
The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors.
Leukemia 1995;9(6):1013-24.
1995: A Tanizawa; Kurt W Kohn; Glenda Kohlhagen; F Leteurtre; Yves Pommier
Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives.
Biochemistry 1995;34(21):7200-6.
1995: M Gupta; Akira Fujimori; Yves Pommier
Eukaryotic DNA topoisomerases I.
Biochimica et biophysica acta 1995;1262(1):1-14.
1995: F Goldwasser; I Bae; M Valenti; K Torres; Yves Pommier
Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.
Cancer research 1995;55(10):2116-21.
1995: F Leteurtre; D L Sackett; J Madalengoitia; Glenda Kohlhagen; T MacDonald; E Hamel; KD Paull; Yves Pommier
Azatoxin derivatives with potent and selective action on topoisomerase II.
Biochemical pharmacology 1995;49(9):1283-90.
1995: A Mazumder; K Raghavan; J Weinstein; Kurt W Kohn; Yves Pommier
Inhibition of human immunodeficiency virus type-1 integrase by curcumin.
Biochemical pharmacology 1995;49(8):1165-70.
1995: K Raghavan; J K Buolamwini; M R Fesen; Yves Pommier; Kurt W Kohn; John N Weinstein
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.
Journal of medicinal chemistry 1995;38(6):890-7.
1995: Akira Fujimori; W G Harker; Glenda Kohlhagen; Yuko Hoki; Yves Pommier
Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin.
Cancer research 1995;55(6):1339-46.
1995: T Shimizu; Patrick M O'Connor; Kurt W Kohn; Yves Pommier
Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage.
Cancer research 1995;55(2):228-31.
1995: A Mazumder; M Gupta; D M Perrin; David S Sigman; M Rabinovitz; Yves Pommier
Inhibition of human immunodeficiency virus type 1 integrase by a hydrophobic cation: the phenanthroline-cuprous complex.
AIDS research and human retroviruses 1995;11(1):115-25.
1995: R Kapoor; D L Slade; Akira Fujimori; Yves Pommier; W G Harker
Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin.
Oncology research 1995;7(2):83-95.
1994: Yves Pommier; B Poddevin; M Gupta; J Jenkins
DNA topoisomerases I & II cleavage sites in the type 1 human immunodeficiency virus (HIV-1) DNA promoter region.
Biochemical and biophysical research communications 1994;205(3):1601-9.
1994: F Leteurtre; Akira Fujimori; A Tanizawa; A Chhabra; A Mazumder; Glenda Kohlhagen; H Nakano; Yves Pommier
Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions.
The Journal of biological chemistry 1994;269(46):28702-7.
1994: A Mazumder; M Gupta; Yves Pommier
Methylphosphonodiester substitution near the conserved CA dinucleotide in the HIV LTR alters both extent of 3'-processing and choice of nucleophile by HIV-1 integrase.
Nucleic acids research 1994;22(21):4441-8.
1994: F Leteurtre; Glenda Kohlhagen; Yves Pommier
Streptonigrin-induced topoisomerase II sites exhibit base preferences in the middle of the enzyme stagger.
Biochemical and biophysical research communications 1994;203(2):1259-67.
1994: F Leteurtre; Glenda Kohlhagen; KD Paull; Yves Pommier
Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen.
Journal of the National Cancer Institute 1994;86(16):1239-44.
1994: M R Fesen; Yves Pommier; F Leteurtre; S Hiroguchi; J Yung; Kurt W Kohn
Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.
Biochemical pharmacology 1994;48(3):595-608.
1994: Eric Solary; Yi-He Ling; Roman Perez-Soler; Waldemar Priebe; Yves Pommier
Hydroxyrubicin, a deaminated derivative of doxorubicin, inhibits mammalian DNA topoisomerase II and partially circumvents multidrug resistance.
International journal of cancer. Journal international du cancer 1994;58(1):85-94.
1994: A Mazumder; D Cooney; Riad Agbaria; M Gupta; Yves Pommier
Inhibition of human immunodeficiency virus type 1 integrase by 3'-azido-3'-deoxythymidylate.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):5771-5.
1994: A Tanizawa; Akira Fujimori; Y Fujimori; Yves Pommier
Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials.
Journal of the National Cancer Institute 1994;86(11):836-42.
1994: Eric Solary; R Bertrand; Yves Pommier
Apoptosis of human leukemic HL-60 cells induced to differentiate by phorbol ester treatment.
Leukemia 1994;8(5):792-7.
1994: F Leteurtre; Glenda Kohlhagen; M R Fesen; A Tanizawa; Kurt W Kohn; Yves Pommier
Effects of DNA methylation on topoisomerase I and II cleavage activities.
The Journal of biological chemistry 1994;269(11):7893-900.
1994: Yves Pommier; A Tanizawa; Kurt W Kohn
Mechanisms of topoisomerase I inhibition by anticancer drugs.
Advances in pharmacology (San Diego, Calif.) 1994;29B():73-92.
1994: Yves Pommier; F Leteurtre; M R Fesen; Akira Fujimori; R Bertrand; Eric Solary; Glenda Kohlhagen; Kurt W Kohn
Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors.
Cancer investigation 1994;12(5):530-42.
1993: A Tanizawa; R Beitrand; Glenda Kohlhagen; A Tabuchi; J Jenkins; Yves Pommier
Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.
The Journal of biological chemistry 1993;268(34):25463-8.
1993: A Tanizawa; Kurt W Kohn; Yves Pommier
Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin.
Nucleic acids research 1993;21(22):5157-66.
1993: B Poddevin; J F Riou; F Lavelle; Yves Pommier
Dual topoisomerase I and II inhibition by intoplicine (RP-60475), a new antitumor agent in early clinical trials.
Molecular pharmacology 1993;44(4):767-74.
1993: S Kamesaki; H Kamesaki; Timothy Jorgensen; A Tanizawa; Yves Pommier; J Cossman
bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.
Cancer research 1993;53(18):4251-6.
1993: F Leteurtre; M Fesen; Glenda Kohlhagen; Kurt W Kohn; Yves Pommier
Specific interaction of camptothecin, a topoisomerase I inhibitor, with guanine residues of DNA detected by photoactivation at 365 nm.
Biochemistry 1993;32(34):8955-62.
1993: Eric Solary; F Leteurtre; KD Paull; Dominic A Scudiero; E Hamel; Yves Pommier
Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent.
Biochemical pharmacology 1993;45(12):2449-56.
1993: M R Fesen; Kurt W Kohn; F Leteurtre; Yves Pommier
Inhibitors of human immunodeficiency virus integrase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2399-403.
1993: Eric Solary; R Bertrand; Kurt W Kohn; Yves Pommier
Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors.
Blood 1993;81(5):1359-68.
1993: Giovanni Capranico; S Tinelli; Franco Zunino; K W Kohn; Yves Pommier
Effects of base mutations on topoisomerase II DNA cleavage stimulated by mAMSA in short DNA oligomers.
Biochemistry 1993;32(1):145-52.
1993: Yves Pommier
DNA topoisomerase I and II in cancer chemotherapy: update and perspectives.
Cancer chemotherapy and pharmacology 1993;32(2):103-8.
1992: Eric Solary; R Bertrand; J Jenkins; Yves Pommier
Radiolabeling of DNA can induce its fragmentation in HL-60 human promyelocytic leukemic cells.
Experimental cell research 1992;203(2):495-8.
1992: F Leteurtre; J Madalengoitia; A Orr; T J Guzi; E Lehnert; T Macdonald; Yves Pommier; T J Cuzi
Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin.
Cancer research 1992;52(16):4478-83.
1992: R Ding; Yves Pommier; V H Kang; Mark E Smulson
Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.
The Journal of biological chemistry 1992;267(18):12804-12.
1992: Yves Pommier; A Orr; Kurt W Kohn; J F Riou
Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.
Cancer research 1992;52(11):3125-30.
1992: A Tanizawa; Yves Pommier
Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture.
Cancer research 1992;52(7):1848-54.
1992: R Bertrand; Patrick M O'Connor; D Kerrigan; Yves Pommier
Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells.
European journal of cancer (Oxford, England : 1990) 1992;28A(4-5):743-8.
1991: Yves Pommier; G Capranico; A Orr; Kurt W Kohn
Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs.
Journal of molecular biology 1991;222(4):909-24.
1991: R Bertrand; M Sarang; J Jenkin; D Kerrigan; Yves Pommier
Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression.
Cancer research 1991;51(23 Pt 1):6280-5.
1991: Yves Pommier; G Capranico; A Orr; Kurt W Kohn
Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.
Nucleic acids research 1991;19(21):5973-80.
1991: C Jaxel; G Capranico; D Kerrigan; Kurt W Kohn; Yves Pommier
Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.
The Journal of biological chemistry 1991;266(30):20418-23.
1991: Patrick M O'Connor; W Nieves-Neira; D Kerrigan; R Bertrand; Jonathan Goldman; Kurt W Kohn; Yves Pommier
S-phase population analysis does not correlate with the cytotoxicity of camptothecin and 10,11-methylenedioxycamptothecin in human colon carcinoma HT-29 cells.
Cancer communications 1991;3(8):233-40.
1991: R Bertrand; D Kerrigan; M Sarang; Yves Pommier
Cell death induced by topoisomerase inhibitors. Role of calcium in mammalian cells.
Biochemical pharmacology 1991;42(1):77-85.
1991: Yves Pommier; Thomas M. Ruenger; D Kerrigan; Kenneth H Kraemer
Relationship of DNA strand breakage produced by bromodeoxyuridine to topoisomerase II activity in Bloom-syndrome fibroblasts.
Mutation research 1991;254(2):185-90.
1990: G Capranico; Kurt W Kohn; Yves Pommier
Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.
Nucleic acids research 1990;18(22):6611-9.
1990: G Capranico; C Jaxel; M Roberge; Kurt W Kohn; Yves Pommier
Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin.
Nucleic acids research 1990;18(15):4553-9.
1990: K Wassermann; J Markovits; C Jaxel; G Capranico; Kurt W Kohn; Yves Pommier
Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II.
Molecular pharmacology 1990;38(1):38-45.
1990: Yves Pommier; D Kerrigan; K D Hartman; R I Glazer
Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.
The Journal of biological chemistry 1990;265(16):9418-22.
1990: G Capranico; F Zunino; Kurt W Kohn; Yves Pommier
Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity.
Biochemistry 1990;29(2):562-9.
1990: Patrick M O'Connor; D Kerrigan; R Bertrand; Kurt W Kohn; Yves Pommier
10,11-Methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells.
Cancer communications 1990;2(12):395-400.
1990: B K Sinha; P M Politi; H M Eliot; D Kerrigan; Yves Pommier
Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide.
European journal of cancer (Oxford, England : 1990) 1990;26(5):590-3.
1990: Yves Pommier; P N Cockerill; Kurt W Kohn; William T Garrard
Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites.
Journal of virology 1990;64(1):419-23.
1990: Kishor Bhatia; Yves Pommier; C Giri; A J Fornace; M Imaizumi; T R Breitman; Barry Cherney; Mark E Smulson
Expression of the poly(ADP-ribose) polymerase gene following natural and induced DNA strand breakage and effect of hyperexpression on DNA repair.
Carcinogenesis 1990;11(1):123-8.
1989: C Holm; J M Covey; D Kerrigan; Yves Pommier
Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.
Cancer research 1989;49(22):6365-8.
1989: J M Covey; C Jaxel; Kurt W Kohn; Yves Pommier
Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.
Cancer research 1989;49(18):5016-22.
1989: M Fesen; Yves Pommier
Mammalian topoisomerase II activity is modulated by the DNA minor groove binder distamycin in simian virus 40 DNA.
The Journal of biological chemistry 1989;264(19):11354-9.
1989: C Jaxel; Kurt W Kohn; M C Wani; M E Wall; Yves Pommier
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.
Cancer research 1989;49(6):1465-9.
1989: Yves Pommier; D Kerrigan; Kurt W Kohn
Topological complexes between DNA and topoisomerase II and effects of polyamines.
Biochemistry 1989;28(3):995-1002.
1988: C Jaxel; Kurt W Kohn; Yves Pommier
Topoisomerase I interaction with SV40 DNA in the presence and absence of camptothecin.
Nucleic acids research 1988;16(23):11157-70.
1988: B K Sinha; N Haim; L Dusre; D Kerrigan; Yves Pommier
DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action.
Cancer research 1988;48(18):5096-100.
1988: J M Covey; Kurt W Kohn; D Kerrigan; E J Tilchen; Yves Pommier
Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity.
Cancer research 1988;48(4):860-5.
1988: Yves Pommier; D Kerrigan; J M Covey; C S Kao-Shan; J Whang-Peng
Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.
Cancer research 1988;48(3):512-6.
1987: Yves Pommier; J Covey; D Kerrigan; William Mattes; J Markovits; Kurt W Kohn
Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines.
Biochemical pharmacology 1987;36(20):3477-86.
1987: Yves Pommier; J M Covey; D Kerrigan; J Markovits; R Pham
DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators.
Nucleic acids research 1987;15(16):6713-31.
1987: J Markovits; Yves Pommier; D Kerrigan; J M Covey; E J Tilchen; Kurt W Kohn
Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.
Cancer research 1987;47(8):2050-5.
1987: Kurt W Kohn; Yves Pommier; D Kerrigan; J Markovits; J M Covey
Topoisomerase II as a target of anticancer drug action in mammalian cells.
NCI monographs : a publication of the National Cancer Institute 1987;(4):61-71.