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Olaf Pongs

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Markus Weingarth; Alexandre M J J Bonvin; Deepak Nand; Olaf Pongs; Alexander Prokofyev; Elwin A W van der Cruijsen; Marc Baldus
Structural determinants of specific lipid binding to potassium channels.
Benjamin Schattling; Karin Steinbach; Edda Thies; Friederike Ufer; Rudi Vennekens; Wolfgang Brück; Veit Flockerzi; Marc Freichel; Matthias Kneussel; Martin Kruse; Aurélie Menigoz; Doron Merkler; Olaf Pongs; Manuel A Friese
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Markus Weingarth; Adrien S J Melquiond; Christian Ader; Stefan Becker; Alexandre M J J Bonvin; Deepak Nand; Olaf Pongs; Marc Baldus
Supramolecular structure of membrane-associated polypeptides by combining solid-state NMR and molecular dynamics simulations.

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All Publications

2013: Markus Weingarth; Alexandre M J J Bonvin; Deepak Nand; Olaf Pongs; Alexander Prokofyev; Elwin A W van der Cruijsen; Marc Baldus
Structural determinants of specific lipid binding to potassium channels.
Journal of the American Chemical Society 2013;135(10):3983-8.
2012: Benjamin Schattling; Karin Steinbach; Edda Thies; Friederike Ufer; Rudi Vennekens; Wolfgang Brück; Veit Flockerzi; Marc Freichel; Matthias Kneussel; Martin Kruse; Aurélie Menigoz; Doron Merkler; Olaf Pongs; Manuel A Friese
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Nature medicine 2012;18(12):1805-11.
2012: Markus Weingarth; Adrien S J Melquiond; Christian Ader; Stefan Becker; Alexandre M J J Bonvin; Deepak Nand; Olaf Pongs; Marc Baldus
Supramolecular structure of membrane-associated polypeptides by combining solid-state NMR and molecular dynamics simulations.
Biophysical journal 2012;103(1):29-37.
2012: Pétur O Heidarsson; Gitte A Jensen; Ida J Bjerrum-Bohr; Bryan E Finn; Olaf Pongs; Flemming M Poulsen; Birthe Kragelund
The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺₋ activated state.
Journal of molecular biology 2012;417(1-2):51-64.
2012: Vitya Vardanyan; Olaf Pongs
Coupling of voltage-sensors to the channel pore: a comparative view.
Frontiers in pharmacology 2012;3():145.
2012: David A Köpfer; Iris Ohmert; Olaf Pongs; Gert Vriend; Bert L de Groot; Ulrike Hahn; Ulrich Zachariae
A molecular switch driving inactivation in the cardiac K+ channel HERG.
PloS one 2012;7(7):e41023.
2010: Michael Klaiber; Martin Kruse; Katharina Völker; Juliane Schröter; Robert Feil; Marc Freichel; Andrea Gerling; Susanne Feil; Alexander Dietrich; Juan Eduardo Camacho Londoño; Hideo A Baba; Joel Abramowitz; Lutz Birnbaumer; Josef M Penninger; Olaf Pongs; Michaela Kuhn
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.
Basic research in cardiology 2010;105(5):583-95.
2010: Hui Liu; Loubna El Zein; Martin Kruse; Romain Guinamard; Alf Beckmann; André Bozio; Andersen Jerome; André Mégarbané; Iris Ohmert; Gérard Blaysat; Elisabeth Villain; Olaf Pongs; Patrice Bouvagnet
Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease.
Circulation. Cardiovascular genetics 2010;3(4):374-85.
2010: Olaf Pongs; Jürgen R Schwarz
Ancillary subunits associated with voltage-dependent K+ channels.
Physiological reviews 2010;90(2):755-96.
2010: Christian Ader; Olaf Pongs; Stefan Becker; Marc Baldus
Protein dynamics detected in a membrane-embedded potassium channel using two-dimensional solid-state NMR spectroscopy.
Biochimica et biophysica acta 2010;1798(2):286-90.
2009: Christian Ader; Robert Schneider; Sönke Hornig; Phanindra Velisetty; Vitya Vardanyan; Karin Giller; Iris Ohmert; Stefan Becker; Olaf Pongs; Marc Baldus
Coupling of activation and inactivation gate in a K+-channel: potassium and ligand sensitivity.
The EMBO journal 2009;28(18):2825-34.
2009: Martin Kruse; Eric Schulze-Bahr; Valerie Corfield; Alf Beckmann; Birgit Stallmeyer; Andersen Jerome; Iris Ohmert; Eric Schulze-Bahr; Paul Brink; Olaf Pongs
Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I.
The Journal of clinical investigation 2009;119(9):2737-44.
2009: Yoni Haitin; Reuven Wiener; Dana Shaham; Asher Peretz; Enbal Ben-Tal Cohen; Liora Shamgar; Olaf Pongs; Joel A Hirsch; Bernard Attali
Intracellular domains interactions and gated motions of I(KS) potassium channel subunits.
The EMBO journal 2009;28(14):1994-2005.
2009: Olaf Pongs
Ins and outs of cardiac voltage-gated potassium channels.
Current opinion in pharmacology 2009;9(3):311-5.
2009: Olaf Pongs
TREKing noxious thermosensation.
The EMBO journal 2009;28(9):1195-6.
2008: Robert Schneider; Christian Ader; Adam Lange; Karin Giller; Sönke Hornig; Olaf Pongs; Stefan Becker; Marc Baldus
Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers.
Journal of the American Chemical Society 2008;130(23):7427-35.
2008: Christian Ader; Robert Schneider; Sönke Hornig; Phanindra Velisetty; Erica M Wilson; Adam Lange; Karin Giller; Iris Ohmert; Marie-France Martin-Eauclaire; Dirk Trauner; Stefan Becker; Olaf Pongs; Marc Baldus
A structural link between inactivation and block of a K+ channel.
Nature structural & molecular biology 2008;15(6):605-12.
2008: Olaf Pongs
Ion Channel Target--Informa conference.
IDrugs : the investigational drugs journal 2008;11(5):318-21.
2008: Ulrich Zachariae; Robert Schneider; Phanindra Velisetty; Adam Lange; Daniel Seeliger; Sören J Wacker; Yasmin Karimi-Nejad; Gert Vriend; Stefan Becker; Olaf Pongs; Marc Baldus; Bert L de Groot
The molecular mechanism of toxin-induced conformational changes in a potassium channel: relation to C-type inactivation.
Structure (London, England : 1993) 2008;16(5):747-54.
2008: Jegannath Korukottu; Robert Schneider; Vinesh Vijayan; Adam Lange; Olaf Pongs; Stefan Becker; Marc Baldus; Markus Zweckstetter
High-resolution 3D structure determination of kaliotoxin by solid-state NMR spectroscopy.
PloS one 2008;3(6):e2359.
2007: Christian Legros; Marie-France Martin-Eauclaire; Olaf Pongs; Pierre E Bougis
Toxin binding to chimeric K+ channels immobilised on a solid nitrocellulose support.
Biochemical and biophysical research communications 2007;353(4):1086-90.
2006: Chi-un Choe; Eric Schulze-Bahr; Axel Neu; Jun Xu; Zheng I Zhu; Kathrin Sauter; Robert Bähring; Silvia Priori; Pascale Guicheney; Gerold Mönnig; Carlo Neapolitano; Jan Heidemann; colleen clancy; Olaf Pongs; Dirk Isbrandt
C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.
Human molecular genetics 2006;15(19):2888-902.
2006: Matthias Oelze; Ascan Warnholtz; Jörg Faulhaber; Philip Wenzel; Andrei L Kleschyov; Meike Coldewey; Ulrich Hink; Olaf Pongs; Ingrid Fleming; Sven Wassmann; Thomas Meinertz; Heimo Ehmke; Andreas Daiber; Thomas Münzel
NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1753-9.
2006: Liora Shamgar; Lijuan Ma; Nicole Schmitt; Yoni Haitin; Asher Peretz; Reuven Wiener; Joel Hirsch; Olaf Pongs; Bernard Attali
Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations.
Circulation research 2006;98(8):1055-63.
2006: Adam Lange; Karin Giller; Sönke Hornig; Marie-France Martin-Eauclaire; Olaf Pongs; Stefan Becker; Marc Baldus
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR.
Nature 2006;440(7086):959-62.
2006: Adam Lange; Karin Giller; Olaf Pongs; Stefan Becker; Marc Baldus
Two-dimensional solid-state NMR applied to a chimeric potassium channel.
Journal of receptor and signal transduction research 2006;26(5-6):379-93.
2005: Britta Callsen; Dirk Isbrandt; Kathrin Sauter; L Sven Hartmann; Olaf Pongs; Robert Bähring
Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected].
The Journal of physiology 2005;568(Pt 2):397-412.
2005: Adam Lange; Stefan Becker; Karsten Seidel; Karin Giller; Olaf Pongs; Marc Baldus
A concept for rapid protein-structure determination by solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2005;44(14):2089-92.
2005: H Christian Peters; Hua Hu; Olaf Pongs; Johan F Storm; Dirk Isbrandt
Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior.
Nature neuroscience 2005;8(1):51-60.
2004: Annette Scholle; Thomas Zimmer; Rolf Koopmann; Birgit Engeland; Olaf Pongs; Klaus Benndorf
Effects of Kv1.2 intracellular regions on activation of Kv2.1 channels.
Biophysical journal 2004;87(2):873-82.
2004: Jan Ebbinghaus; Christian Legros; Andreas Nolting; Catherine Guette; Marie-Louise Celerier; Olaf Pongs; Robert Bähring
Modulation of Kv4.2 channels by a peptide isolated from the venom of the giant bird-eating tarantula Theraphosa leblondi.
Toxicon : official journal of the International Society on Toxinology 2004;43(8):923-32.
2004: martina Sinnegger-Brauns; Alfred Hetzenauer; Irene G Huber; Erik Renström; Georg Wietzorrek; Stanislav Berjukov; Maurizio Cavalli; Doris Walter; alexandra koschak; Ralph Waldschütz; Steffen Hering; Sergio Bova; Patrik Rorsman; Olaf Pongs; Nicolas Singewald; J öRg Striessnig J
Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels.
The Journal of clinical investigation 2004;113(10):1430-9.
2004: Annette Scholle; S Dugarmaa; Thomas Zimmer; M Leonhardt; Rolf Koopmann; Birgit Engeland; Olaf Pongs; Klaus Benndorf
Rate-limiting reactions determining different activation kinetics of Kv1.2 and Kv2.1 channels.
The Journal of membrane biology 2004;198(2):103-12.
2004: Horst Wedekind; M Schwarz; S Hauenschild; H Djonlagic; Wilhelm Haverkamp; Günter Breithardt; T Wülfing; Olaf Pongs; Dirk Isbrandt; Eric Schulze-Bahr
Effective long-term control of cardiac events with beta-blockers in a family with a common LQT1 mutation.
Clinical genetics 2004;65(3):233-41.
2004: Siyong Teng; Lijuan Ma; Yingxue Dong; Chunxia Lin; Jue Ye; Robert Bähring; Vitya Vardanyan; Yanzong Yang; Zhihu Lin; Olaf Pongs; Rutai Hui
Clinical and electrophysiological characterization of a novel mutation R863X in HERG C-terminus associated with long QT syndrome.
Journal of molecular medicine (Berlin, Germany) 2004;82(3):189-96.
2004: Manuel Gebauer; Dirk Isbrandt; Kathrin Sauter; Britta Callsen; Andreas Nolting; Olaf Pongs; Robert Bähring
N-type inactivation features of Kv4.2 channel gating.
Biophysical journal 2004;86(1 Pt 1):210-23.
2004: Robert Bähring; Vitya Vardanyan; Olaf Pongs
Differential modulation of Kv1 channel-mediated currents by co-expression of Kvbeta3 subunit in a mammalian cell-line.
Molecular membrane biology 2004;21(1):19-25.
2003: Thomas Strahl; Birgit Grafelmann; Jens Dannenberg; Jeremy Thorner; Olaf Pongs
Conservation of regulatory function in calcium-binding proteins: human frequenin (neuronal calcium sensor-1) associates productively with yeast phosphatidylinositol 4-kinase isoform, Pik1.
The Journal of biological chemistry 2003;278(49):49589-99.
2003: Lijuan Ma; Chunxia Lin; Siyong Teng; Yongping Chai; Robert Bähring; Vitya Vardanyan; Liang Li; Olaf Pongs; Rutai Hui
Characterization of a novel Long QT syndrome mutation G52R-KCNE1 in a Chinese family.
Cardiovascular research 2003;59(3):612-9.
2003: Laura Conforti; Koichi Takimoto; Milan Petrovic; Olaf Pongs; David E Millhorn
The pore region of the Kv1.2alpha subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity.
Biochemical and biophysical research communications 2003;306(2):450-6.
2003: Mark A Punke; Thomas Licher; Olaf Pongs; Patrick Friederich
Inhibition of human TREK-1 channels by bupivacaine.
Anesthesia and analgesia 2003;96(6):1665-73, table of contents.
2003: Morten Grunnet; Thomas Jespersen; Nanna MacAulay; Nanna K Jørgensen; Nicole Schmitt; Olaf Pongs; Søren-Peter Olesen; Dan A Klaerke
KCNQ1 channels sense small changes in cell volume.
The Journal of physiology 2003;549(Pt 2):419-27.
2003: Eric Schulze-Bahr; Axel Neu; Patrick Friederich; U Benjamin Kaupp; Günter Breithardt; Olaf Pongs; Dirk Isbrandt
Pacemaker channel dysfunction in a patient with sinus node disease.
The Journal of clinical investigation 2003;111(10):1537-45.
2003: Siyong Teng; Lijuan Ma; Yisong Zhen; ChunXia Lin; Robert Bähring; Vitya Vardanyan; Olaf Pongs; Rutai Hui
Novel gene hKCNE4 slows the activation of the KCNQ1 channel.
Biochemical and biophysical research communications 2003;303(3):808-13.
2003: Patrick Friederich; James P Dilger; Dirk Isbrandt; Kathrin Sauter; Olaf Pongs; Bernd W Urban
Biophysical properties of Kv3.1 channels in SH-SY5Y human neuroblastoma cells.
Receptors & channels 2003;9(6):387-96.
2002: Christian Legros; Christian Schulze; Maria L Garcia; Pierre E Bougis; Marie-France Martin-Eauclaire; Olaf Pongs
Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsA.
Biochemistry 2002;41(51):15369-75.
2002: Dirk Isbrandt; Patrick Friederich; Anna Solth; Wilhelm Haverkamp; Andreas Ebneth; Martin Borggrefe; Harald Funke; Kathrin Sauter; Günter Breithardt; Olaf Pongs; Eric Schulze-Bahr
Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.
Journal of molecular medicine (Berlin, Germany) 2002;80(8):524-32.
2001: Hua Hu; LR Shao; S Chavoshy; Ning Gu; Maria Trieb; R Behrens; Petter Laake; Olaf Pongs; Hans-Günther Knaus; Ole Petter Ottersen; Johan F Storm
Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(24):9585-97.
2001: Eric Schulze-Bahr; M Schwarz; S Hauenschild; Horst Wedekind; Harald Funke; Wilhelm Haverkamp; Günter Breithardt; Olaf Pongs; Dirk Isbrandt; S Hoffman
A novel long-QT 5 gene mutation in the C-terminus (V109I) is associated with a mild phenotype.
Journal of molecular medicine (Berlin, Germany) 2001;79(9):504-9.
2001: Matthias Löhn; Birgit Lauterbach; Hermann Haller; Olaf Pongs; Friedrich C Luft; Maik Gollasch
beta(1)-Subunit of BK channels regulates arterial wall[Ca(2+)] and diameter in mouse cerebral arteries.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(3):1350-4.
2001: Robert Bähring; Linda M Boland; A Varghese; M Gebauer; Olaf Pongs
Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels.
The Journal of physiology 2001;535(Pt 1):65-81.
2001: Rolf Koopmann; Annette Scholle; J Ludwig; Torsten Leicher; Thomas Zimmer; Olaf Pongs; Klaus Benndorf
Role of the S2 and S3 segment in determining the activation kinetics in Kv2.1 channels.
The Journal of membrane biology 2001;182(1):49-59.
2001: Robert Bähring; Jens Dannenberg; H C Peters; Torsten Leicher; Olaf Pongs; Dirk Isbrandt
Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.
The Journal of biological chemistry 2001;276(26):23888-94.
2001: Robert Bähring; Carol J Milligan; Vitya Vardanyan; Birgit Engeland; B A Young; Jens Dannenberg; R Waldschutz; J P Edwards; Dennis Wray; Olaf Pongs
Coupling of voltage-dependent potassium channel inactivation and oxidoreductase active site of Kvbeta subunits.
The Journal of biological chemistry 2001;276(25):22923-9.
2001: Yves Bourne; Jens Dannenberg; V Pollmann; Pascale Marchot; Olaf Pongs
Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1).
The Journal of biological chemistry 2001;276(15):11949-55.
2000: S Plüger; Jörg Faulhaber; M Fürstenau; Matthias Löhn; Ralph Waldschütz; Maik Gollasch; Hermann Haller; Friedrich C Luft; Heimo Ehmke; Olaf Pongs
Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure.
Circulation research 2000;87(11):E53-60.
2000: Cédric Bernard; Christian Legros; Gilles Ferrat; Ulrike Bischoff; A Marquardt; Olaf Pongs; Hervé Darbon
Solution structure of hpTX2, a toxin from Heteropoda venatoria spider that blocks Kv4.2 potassium channel.
Protein science : a publication of the Protein Society 2000;9(11):2059-67.
2000: Ulrike Bischoff; C Schmidt; Rainer Netzer; Olaf Pongs
Effects of fluoroquinolones on HERG currents.
European journal of pharmacology 2000;406(3):341-3.
2000: Sascha Rolf; Wilhelm Haverkamp; Martin Borggrefe; Ulrich Musshoff; Lars Eckardt; J Mergenthaler; D J Snyders; Olaf Pongs; Erwin-Josef Speckmann; Günter Breithardt; Michael Madeja
Effects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(1):22-31.
2000: J Ludwig; R Weseloh; C Karschin; Q Liu; Rainer Netzer; Birgit Engeland; C Stansfeld; Olaf Pongs
Cloning and functional expression of rat eag2, a new member of the ether-à-go-go family of potassium channels and comparison of its distribution with that of eag1.
Molecular and cellular neurosciences 2000;16(1):59-70.
2000: Christian Legros; V Pollmann; Hans-Günther Knaus; A M Farrell; Hervé Darbon; Pierre E Bougis; Marie-France Martin-Eauclaire; Olaf Pongs
Generating a high affinity scorpion toxin receptor in KcsA-Kv1.3 chimeric potassium channels.
The Journal of biological chemistry 2000;275(22):16918-24.
2000: R Behrens; Andreas Nolting; F Reimann; M Schwarz; Ralph Waldschütz; Olaf Pongs
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.
FEBS letters 2000;474(1):99-106.
2000: Dirk Isbrandt; Torsten Leicher; Ralph Waldschütz; X Zhu; Ulrich Luhmann; U Michel; Kathrin Sauter; Olaf Pongs
Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).
Genomics 2000;64(2):144-54.
2000: N Schmitt; M Schwarz; Asher Peretz; I Abitbol; Bernard Attali; Olaf Pongs
A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly.
The EMBO journal 2000;19(3):332-40.
2000: Annette Scholle; Rolf Koopmann; Torsten Leicher; J Ludwig; Olaf Pongs; Klaus Benndorf
Structural elements determining activation kinetics in Kv2.1.
Receptors & channels 2000;7(1):65-75.
1999: Olaf Pongs; Torsten Leicher; M Berger; Jochen Roeper; Robert Bähring; Dennis Wray; peter giese; A J Silva; Johan F Storm
Functional and molecular aspects of voltage-gated K+ channel beta subunits.
Annals of the New York Academy of Sciences 1999;868():344-55.
1999: M Wolters; Michael Madeja; A M Farrell; Olaf Pongs
Bacillus stearothermophilus lctB gene gives rise to functional K+ channels in Escherichia coli and in Xenopus oocytes.
Receptors & channels 1999;6(6):477-91.
1999: X R Zhu; A Wulf; M Schwarz; Dirk Isbrandt; Olaf Pongs
Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current.
Receptors & channels 1999;6(5):387-400.
1999: X R Zhu; Rainer Netzer; K Böhlke; Q Liu; Olaf Pongs
Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel.
Receptors & channels 1999;6(5):337-50.
1998: Torsten Leicher; Robert Bähring; Dirk Isbrandt; Olaf Pongs
Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel.
The Journal of biological chemistry 1998;273(52):35095-101.
1998: Birgit Engeland; Axel Neu; J Ludwig; Jochen Roeper; Olaf Pongs
Cloning and functional expression of rat ether-à-go-go-like K+ channel genes.
The Journal of physiology 1998;513 ( Pt 3)():647-54.
1998: peter giese; Johan F Storm; D Reuter; Nikolai B Fedorov; LR Shao; Torsten Leicher; Olaf Pongs; Alcino J Silva
Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning.
Learning & memory (Cold Spring Harbor, N.Y.) 1998;5(4-5):257-73.
1998: Jochen Roeper; S Sewing; Y Zhang; T Sommer; siegmund wanner; Olaf Pongs
NIP domain prevents N-type inactivation in voltage-gated potassium channels.
Nature 1998;391(6665):390-3.
1998: Christiane K Bauer; Birgit Engeland; Iris Wulfsen; J Ludwig; Olaf Pongs; Jürgen R Schwarz
RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells.
Receptors & channels 1998;6(1):19-29.
1997: J Ludwig; D Owen; Olaf Pongs
Carboxy-terminal domain mediates assembly of the voltage-gated rat ether-à-go-go potassium channel.
The EMBO journal 1997;16(21):6337-45.
1997: J M Gòmez-Hernandez; C Lorra; L A Pardo; Walter Stühmer; Olaf Pongs; S H Heinemann; A A Elliott
Molecular basis for different pore properties of potassium channels from the rat brain Kv1 gene family.
Pflügers Archiv : European journal of physiology 1997;434(6):661-8.
1997: GW Abbott; M Bloemendal; Ivo H M van Stokkum; EA Mercer; R T Miller; S Sewing; M Wolters; Olaf Pongs; Kaila Surjit Srai
Secondary structure, stability and tetramerisation of recombinant K(V)1.1 potassium channel cytoplasmic N-terminal fragment.
Biochimica et biophysica acta 1997;1341(1):71-8.
1997: Heinrich Terlau; Stefan H Heinemann; Walter Stühmer; Olaf Pongs; J Ludwig
Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment.
The Journal of physiology 1997;502 ( Pt 3)():537-43.
1997: Jochen Roeper; C Lorra; Olaf Pongs
Frequency-dependent inactivation of mammalian A-type K+ channel KV1.4 regulated by Ca2+/calmodulin-dependent protein kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(10):3379-91.
1997: Rolf Koopmann; Klaus Benndorf; C Lorra; Olaf Pongs
Functional differences of a Kv2.1 channel and a Kv2.1/Kv1.2S4-chimera are confined to a concerted voltage shift of various gating parameters.
Receptors & channels 1997;5(1):15-28.
1997: C Stansfeld; J Ludwig; Jochen Roeper; R Weseloh; D Brown; Olaf Pongs
A physiological role for ether-à-go-go K+ channels?
Trends in neurosciences 1997;20(1):13-4.
1996: G Laube; J Röper; J C Pitt; S Sewing; U Kistner; Craig C Garner; Olaf Pongs; Rüdiger W Veh
Ultrastructural localization of Shaker-related potassium channel subunits and synapse-associated protein 90 to septate-like junctions in rat cerebellar Pinceaux.
Brain research. Molecular brain research 1996;42(1):51-61.
1996: C E Stansfeld; J Röper; J Ludwig; R M Weseloh; Stephen J Marsh; David A Brown; Olaf Pongs
Elevation of intracellular calcium by muscarinic receptor activation induces a block of voltage-activated rat ether-à-go-go channels in a stably transfected cell line.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9910-4.
1996: Stefan H Heinemann; Jens Rettig; H R Graack; Olaf Pongs
Functional characterization of Kv channel beta-subunits from rat brain.
The Journal of physiology 1996;493 ( Pt 3)():625-33.
1996: Jochen Roeper; Olaf Pongs
Presynaptic potassium channels.
Current opinion in neurobiology 1996;6(3):338-41.
1996: Heinrich Terlau; J Ludwig; R Steffan; Olaf Pongs; Walter Stühmer; Stefan H Heinemann
Extracellular Mg2+ regulates activation of rat eag potassium channel.
Pflügers Archiv : European journal of physiology 1996;432(2):301-12.
1996: S Sewing; J Roeper; Olaf Pongs
Kv beta 1 subunit binding specific for shaker-related potassium channel alpha subunits.
Neuron 1996;16(2):455-63.
1996: Torsten Leicher; Jochen Roeper; K Weber; X Wang; Olaf Pongs
Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B).
Neuropharmacology 1996;35(7):787-95.
1995: Stefan H Heinemann; Jens Rettig; F Wunder; Olaf Pongs
Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit.
FEBS letters 1995;377(3):383-9.
1995: Rüdiger W Veh; Ralf Lichtinghagen; S Sewing; F Wunder; I M Grumbach; Olaf Pongs
Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain.
The European journal of neuroscience 1995;7(11):2189-205.
1995: F Tejedor; X R Zhu; E Kaltenbach; A Ackermann; A Baumann; Inmaculada Canal; M Heisenberg; K F Fischbach; Olaf Pongs
minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila.
Neuron 1995;14(2):287-301.
1994: J Ludwig; Heinrich Terlau; F Wunder; Andrea Bruggemann; Luis A Pardo; A Marquardt; Walter Stühmer; Olaf Pongs
Functional expression of a rat homologue of the voltage gated either á go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart.
The EMBO journal 1994;13(19):4451-8.
1994: Jens Rettig; Stefan H Heinemann; F Wunder; C Lorra; D N Parcej; J Oliver Dolly; Olaf Pongs
Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit.
Nature 1994;369(6478):289-94.
1994: J Oliver Dolly; Jens Rettig; V E Scott; D N Parcej; R Wittkat; S Sewing; Olaf Pongs
Oligomeric and subunit structures of neuronal voltage-sensitive K+ channels.
Biochemical Society transactions 1994;22(2):473-8.
1994: V E Scott; Jens Rettig; D N Parcej; J N Keen; J B Findlay; Olaf Pongs; J Oliver Dolly
Primary structure of a beta subunit of alpha-dendrotoxin-sensitive K+ channels from bovine brain.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1637-41.
1994: V E Scott; Z M Muniz; S Sewing; Ralf Lichtinghagen; D N Parcej; Olaf Pongs; J Oliver Dolly
Antibodies specific for distinct Kv subunits unveil a heterooligomeric basis for subtypes of alpha-dendrotoxin-sensitive K+ channels in bovine brain.
Biochemistry 1994;33(7):1617-23.
1994: R Rivosecchi; Olaf Pongs; T Theil; A Mallart
Implication of frequenin in the facilitation of transmitter release in Drosophila.
The Journal of physiology 1994;474(2):223-32.
1994: S Heinemann; Jens Rettig; V Scott; D N Parcej; C Lorra; J Oliver Dolly; Olaf Pongs
The inactivation behaviour of voltage-gated K-channels may be determined by association of alpha- and beta-subunits.
Journal of physiology, Paris 1994;88(3):173-80.
1993: Andrea Bruggemann; Luis A Pardo; Walter Stühmer; Olaf Pongs
Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP.
Nature 1993;365(6445):445-8.
1993: S Reinhardt-Maelicke; Sabine Kurz; S Sewing; Martin Stocker; Olaf Pongs
Application of an ectopic expression system for the selection of protein-isoform-specific antibodies. The monoclonal antibody K1C3 is specific for the RCK1 potassium channel.
European journal of biochemistry / FEBS 1993;216(3):871-7.
1993: Olaf Pongs; J Lindemeier; X R Zhu; T Theil; D Engelkamp; I Krah-Jentgens; H G Lambrecht; Karl-Wilhelm Koch; J Schwemer; R Rivosecchi
Frequenin--a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system.
Neuron 1993;11(1):15-28.
1993: S Reinhardt-Maelicke; Sabine Kurz; S Sewing; Martin Stocker; Olaf Pongs
The Xenopus oocyte as an ectopic expression system for the selection of protein isoform-specific antibodies.
Journal of receptor research 1993;13(1-4):513-26.
1993: U Ludewig; C Lorra; Olaf Pongs; Stefan H Heinemann
A site accessible to extracellular TEA+ and K+ influences intracellular Mg2+ block of cloned potassium channels.
European biophysics journal : EBJ 1993;22(4):237-47.
1993: Olaf Pongs
Receptor sites for open channel blockers of Shaker voltage-gated potassium channels--molecular approaches.
Journal of receptor research 1993;13(1-4):503-12.
1992: A Ozyhar; M Gries; H H Kiltz; Olaf Pongs
Magnetic DNA affinity purification of ecdysteroid receptor.
The Journal of steroid biochemistry and molecular biology 1992;43(7):629-34.
1992: Olaf Pongs
Structural basis of voltage-gated K+ channel pharmacology.
Trends in pharmacological sciences 1992;13(9):359-65.
1992: P F Reid; Olaf Pongs; J Oliver Dolly
Cloning of a bovine voltage-gated K+ channel gene utilising partial amino acid sequence of a dendrotoxin-binding protein from brain cortex.
FEBS letters 1992;302(1):31-4.
1992: Luis A Pardo; Stefan H Heinemann; Heinrich Terlau; U Ludewig; C Lorra; Olaf Pongs; Walter Stühmer
Extracellular K+ specifically modulates a rat brain K+ channel.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2466-70.
1991: J Peter Ruppersberg; R Frank; Olaf Pongs; Martin Stocker
Cloned neuronal IK(A) channels reopen during recovery from inactivation.
Nature 1991;353(6345):657-60.
1991: A Oyhar; M Strangmann-Diekmann; H H Kiltz; Olaf Pongs
Characterization of a specific ecdysteroid receptor-DNA complex reveals common properties for invertebrate and vertebrate hormone-receptor/DNA interactions.
European journal of biochemistry / FEBS 1991;200(2):329-35.
1991: J Peter Ruppersberg; Martin Stocker; Olaf Pongs; Stefan H Heinemann; R Frank; M Koenen
Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation.
Nature 1991;352(6337):711-4.
1991: Martin Stocker; Olaf Pongs; M Hoth; Stefan H Heinemann; Walter Stühmer; K H Schröter; J Peter Ruppersberg
Swapping of functional domains in voltage-gated K+ channels.
Proceedings. Biological sciences / The Royal Society 1991;245(1313):101-7.
1991: R Wittka; Martin Stocker; G Boheim; Olaf Pongs
Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family.
FEBS letters 1991;286(1-2):193-200.
1991: Walter Stühmer; F Conti; Martin Stocker; Olaf Pongs; Stefan H Heinemann
Gating currents of inactivating and non-inactivating potassium channels expressed in Xenopus oocytes.
Pflügers Archiv : European journal of physiology 1991;418(4):423-9.
1991: K H Schröter; J Peter Ruppersberg; F Wunder; Jens Rettig; Martin Stocker; Olaf Pongs
Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain.
FEBS letters 1991;278(2):211-6.
1991: J A Barbas; J Galceran; I Krah-Jentgens; J L de la Pompa; Inmaculada Canal; Olaf Pongs; Alberto Ferrús
Troponin I is encoded in the haplolethal region of the Shaker gene complex of Drosophila.
Genes & development 1991;5(1):132-40.
1990: Ralf Lichtinghagen; Martin Stocker; R Wittka; G Boheim; Walter Stühmer; A Ferrus; Olaf Pongs
Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster.
The EMBO journal 1990;9(13):4399-407.
1990: Martin Stocker; Walter Stühmer; R Wittka; X Wang; R Müller; A Ferrus; Olaf Pongs
Alternative Shaker transcripts express either rapidly inactivating or noninactivating K+ channels.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8903-7.
1990: A Ozyhar; H H Kiltz; Olaf Pongs
Pyridoxal phosphate inhibits the DNA-binding activity of the ecdysteroid receptor.
European journal of biochemistry / FEBS 1990;192(1):167-74.
1990: J Peter Ruppersberg; K H Schröter; Bert Sakmann; Martin Stocker; S Sewing; Olaf Pongs
Heteromultimeric channels formed by rat brain potassium-channel proteins.
Nature 1990;345(6275):535-7.
1990: A Grupe; K H Schröter; J Peter Ruppersberg; Martin Stocker; T Drewes; S Beckh; Olaf Pongs
Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.
The EMBO journal 1990;9(6):1749-56.
1990: Alberto Ferrús; S Llamazares; J L de la Pompa; M A Tanouye; Olaf Pongs
Genetic analysis of the Shaker gene complex of Drosophila melanogaster.
Genetics 1990;125(2):383-98.
1990: M Strangmann-Diekmann; A Klöne; A Ozyhar; F Kreklau; H H Kiltz; U Hedtmann; Peter Welzel; Olaf Pongs
Affinity labelling of a partially purified ecdysteroid receptor with a bromoacetylated 20-OH-ecdysone derivative.
European journal of biochemistry / FEBS 1990;189(1):137-43.
1990: Christer Betsholtz; A Baumann; S Kenna; F M Ashcroft; Stephen J H Ashcroft; Per-Olof Berggren; A Grupe; Olaf Pongs; P Rorsman; J Sandblom
Expression of voltage-gated K+ channels in insulin-producing cells. Analysis by polymerase chain reaction.
FEBS letters 1990;263(1):121-6.
1990: S Beckh; Olaf Pongs
Members of the RCK potassium channel family are differentially expressed in the rat nervous system.
The EMBO journal 1990;9(3):777-82.
1989: Walter Stühmer; J Peter Ruppersberg; K H Schröter; Bert Sakmann; Martin Stocker; peter giese; A Perschke; A Baumann; Olaf Pongs
Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
The EMBO journal 1989;8(11):3235-44.
1989: G Feigl; M Gram; Olaf Pongs
A member of the steroid hormone receptor gene family is expressed in the 20-OH-ecdysone inducible puff 75B in Drosophila melanogaster.
Nucleic acids research 1989;17(18):7167-78.
1989: Günter Gisselmann; S Sewing; B W Madsen; A Mallart; D Angaut-Petit; F Müller-Holtkamp; A Ferrus; Olaf Pongs
The interference of truncated with normal potassium channel subunits leads to abnormal behaviour in transgenic Drosophila melanogaster.
The EMBO journal 1989;8(8):2359-64.
1989: R Janknecht; W Taube; H J Lüdecke; Olaf Pongs
Characterization of a putative transcription factor gene expressed in the 20-OH-ecdysone inducible puff 74EF in Drosophila melanogaster.
Nucleic acids research 1989;17(12):4455-64.
1989: U Kanngiesser; Olaf Pongs
Binding Ca2+ to intracellular or to extracellular sites of dihydropyridine receptor of rabbit skeletal muscle discriminates between in vitro binding of Ca2+-channel agonist and antagonist.
European journal of biochemistry / FEBS 1989;181(2):467-73.
1989: J A Barbas; N Rubio; E Pedroso; Olaf Pongs; Alberto Ferrús
Antibodies against Drosophila potassium channels identify membrane proteins across species.
Brain research. Molecular brain research 1989;5(2):171-6.
1989: Olaf Pongs
Molecular basis of potassium channel diversity.
Pflügers Archiv : European journal of physiology 1989;414 Suppl 1():S71-5.
1988: Walter Stühmer; Martin Stocker; Bert Sakmann; P Seeburg; A Baumann; A Grupe; Olaf Pongs
Potassium channels expressed from rat brain cDNA have delayed rectifier properties.
FEBS letters 1988;242(1):199-206.
1988: A Baumann; A Grupe; A Ackermann; Olaf Pongs
Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems.
The EMBO journal 1988;7(8):2457-63.
1988: Olaf Pongs
Ecdysteroid-regulated gene expression in Drosophila melanogaster.
European journal of biochemistry / FEBS 1988;175(2):199-204.
1988: U Kanngiesser; P Nalik; Olaf Pongs
Purification and affinity labeling of dihydropyridine receptor from rabbit skeletal muscle membranes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):2969-73.
1988: Olaf Pongs; N Kecskemethy; R Müller; I Krah-Jentgens; A Baumann; H H Kiltz; Inmaculada Canal; S Llamazares; A Ferrus
Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.
The EMBO journal 1988;7(4):1087-96.
1987: A Baumann; I Krah-Jentgens; R Müller; F Müller-Holtkamp; R Seidel; N Kecskemethy; J Casal; A Ferrus; Olaf Pongs
Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I(A) channel transcript with homology to vertebrate Na channel.
The EMBO journal 1987;6(11):3419-29.
1984: T Möritz; J E Edström; Olaf Pongs
Cloning of a gene localized and expressed at the ecdysteroid regulated puff 74EF in salivary glands of Drosophila larvae.
The EMBO journal 1984;3(2):289-95.
1983: B Dworniczak; R Seidel; Olaf Pongs
Puffing activities and binding of ecdysteroid to polytene chromosomes of Drosophila melanogaster.
The EMBO journal 1983;2(8):1323-30.