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Chris Ponting

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Mei Zhu; Lena Ehret; Pierre Gönczy; Sachin Kotak; Chris P Ponting; Luis Sanchez-Pulido; Florian Settele; Ingrid Hoffmann
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
Yang I Li; Chris P Ponting; Lesheng Kong; Wilfried Haerty
Rapid evolution of Beta-keratin genes contribute to phenotypic differences that distinguish turtles and birds from other reptiles.
Hannah K Long; Duncan T Odom; Roger Patient; Chris P Ponting; David Sims; Megan L Wright; Neil P Blackledge; Frank Grützner; Andreas Heger; Claudia Kutter; Robert J Klose
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates.

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All Publications

2013: Mei Zhu; Lena Ehret; Pierre Gönczy; Sachin Kotak; Chris P Ponting; Luis Sanchez-Pulido; Florian Settele; Ingrid Hoffmann
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
The Journal of cell biology 2013;200(6):773-87.
2013: Yang I Li; Chris P Ponting; Lesheng Kong; Wilfried Haerty
Rapid evolution of Beta-keratin genes contribute to phenotypic differences that distinguish turtles and birds from other reptiles.
Genome biology and evolution 2013;5(5):923-33.
2013: Hannah K Long; Duncan T Odom; Roger Patient; Chris P Ponting; David Sims; Megan L Wright; Neil P Blackledge; Frank Grützner; Andreas Heger; Claudia Kutter; Robert J Klose
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates.
eLife 2013;2():e00348.
2013: Chris M Rands; Clotilde Teiling; Matthew T Webster; Arhat Abzhanov; Jason Affourtit; Benjamin Boese; Céline Clabaut; Aaron Darling; Jonathan A Eisen; Michael B Eisen; Richard Emes; Matthew Fujita; B Rosemary Grant; Peter R Grant; Michael Brent Hawkins; Andreas Heger; Lesheng Kong; Stephen Meader; Chris P Ponting
Insights into the evolution of Darwin's finches from comparative analysis of the Geospiza magnirostris genome sequence.
BMC genomics 2013;14():95.
2012: Chris P Ponting
Loaded dice for human genome mutation.
Cell 2012;151(7):1399-400.
2012: Ivan M Muñoz; Chris P Ponting; Sonia Rocha; Thomas MacArtney; Luis Sanchez-Pulido; John Rouse
Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.
The Journal of biological chemistry 2012;287(39):32346-53.
2012: Chris P Ponting; Peter L Oliver
Brain, know thy transcriptome, know thyself.
Neuron 2012;75(4):543-5.
2012: Luis Sanchez-Pulido; Lesheng Kong; Chris P Ponting
A common ancestry for BAP1 and Uch37 regulators.
Bioinformatics (Oxford, England) 2012;28(15):1953-6.
2012: Monika S Kowalczyk; Gillian M Morriss-Kay; Chris P Ponting; Amy E Roberts; Luis Sanchez-Pulido; Jacqueline A Sharpe; Jacqueline A Sloane-Stanley; Leslie B Smoot; Dorota Szumska; Hugh Watkins; William G Wood; Christian Babbs; Shoumo Bhattacharya; Richard J Gibbons; Jim R Hughes; Douglas R Higgs
Nprl3 is required for normal development of the cardiovascular system.
Mammalian genome : official journal of the International Mammalian Genome Society 2012;23(7-8):404-15.
2012: Anca M Farcas; Benedikt M Kessler; Neil P Blackledge; Neil Brockdorff; Andrea Cerase; Haruhiko Koseki; Sheena Lee; Hannah K Long; Joanna F McGouran; Chris P Ponting; Nathan R Rose; Thomas W Sheahan; David Sims; Ian Sudbery; Robert J Klose
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.
eLife 2012;1():e00205.
2012: Martin Goodson; Richard Mott; Chris P Ponting; Marco B Rust; Walter Witke; David Bannerman; Jonathan Flint
Cofilin-1: a modulator of anxiety in mice.
PLoS genetics 2012;8(10):e1002970.
2012: Claudia Kutter; Angela Goncalves; Duncan T Odom; Chris P Ponting; Klara Stefflova; Stephen Watt; Michael D Wilson; Ana C Marques
Rapid turnover of long noncoding RNAs and the evolution of gene expression.
PLoS genetics 2012;8(7):e1002841.
2012: Christoffer Nellåker; Kim Wong; Binnaz Yalcin; David J Adams; Avigail Agam; T Grant Belgard; Jonathan Flint; Wayne N Frankel; Thomas M Keane; Chris P Ponting
The genomic landscape shaped by selection on transposable elements across 18 mouse strains.
Genome biology 2012;13(6):R45.
2012: Petr Danecek; Richard Durbin; Jonathan Flint; Thomas M Keane; Rebecca E McIntyre; Christoffer Nellåker; Chris P Ponting; Jorge E Buendia-Buendia; Suzannah Bumpstead; David J Adams
High levels of RNA-editing site conservation amongst 15 laboratory mouse strains.
Genome biology 2012;13(4):26.
2012: Robert S Young; Charlotte Tibbit; Andrew R Bassett; Wilfried Haerty; Ji-Long Liu; Ana C Marques; Chris P Ponting
Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome.
Genome biology and evolution 2012;4(4):427-42.
2012: Erik Axelsson; Chris P Ponting; Abhirami Ratnakumar; Matthew T Webster; Kerstin Lindblad-Toh
Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.
Genome research 2012;22(1):51-63.
2011: Chris P Ponting; Ross C Hardison
What fraction of the human genome is functional?
Genome research 2011;21(11):1769-76.
2011: Luis Sanchez-Pulido; Chris P Ponting
Structure and evolutionary history of DISC1.
Human molecular genetics 2011;20(R2):R175-81.
2011: Chris P Ponting; Christoffer Nellåker; Stephen Meader
Rapid turnover of functional sequence in human and other genomes.
Annual review of genomics and human genetics 2011;12():275-99.
2011: T Grant Belgard; Fernando García-Moreno; Anna Hoerder-Suabedissen; Elliott H Margulies; Ana C Marques; Zoltán Molnár; Peter L Oliver; Hatice Ozel Abaan; Tamara M Sirey; Chris P Ponting
A transcriptomic atlas of mouse neocortical layers.
Neuron 2011;71(4):605-16.
2011: Paola Vagnarelli; Toon Verheyen; Flavia de Lima Alves; David A Kelly; Chris P Ponting; Juri Rappsilber; Susana Ribeiro; Luis Sanchez-Pulido; Lau Sennels; William C Earnshaw
Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit.
Developmental cell 2011;21(2):328-42.
2011: Luis Sanchez-Pulido; Chris P Ponting
Cdc45: the missing RecJ ortholog in eukaryotes?
Bioinformatics (Oxford, England) 2011;27(14):1885-8.
2011: Dominik Boos; Antony Oliver; Laurence H Pearl; Chris P Ponting; Mathieu Rappas; Luis Sanchez-Pulido; John F X Diffley
Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.
Current biology : CB 2011;21(13):1152-7.
2011: Michael B Clark; Marcel Dinger; Mark B Gerstein; Thomas R Gingeras; Yoshihide Hayashizaki; Paulo P Amaral; piero carninci; Antonin Morillon; Kevin V Morris; Chris P Ponting; John L Rinn; Joel S Rozowsky; Felix J Schlesinger; Peter F Stadler; Ryan J Taft; Claes Wahlestedt; John S Mattick
The reality of pervasive transcription.
PLoS biology 2011;9(7):e1000625; discussion e1001102.
2011: Ryan Mills; W Stephen Pittard; Julienne M Mullaney; Umar Farooq; Todd H Creasy; Anup A Mahurkar; David M Kemeza; Daniel S Strassler; Chris P Ponting; Caleb Webber; Scott Devine
Natural genetic variation caused by small insertions and deletions in the human genome.
Genome research 2011;21(6):830-9.
2011: Chris P Ponting
What are the genomic drivers of the rapid evolution of PRDM9?
Trends in genetics : TIG 2011;27(5):165-71.
2011: Leo Goodstadt; Chris P Ponting
Is the control of recombination conserved among diverse eukaryotes?
Heredity 2011;106(5):710-1.
2011: Tamim H Shaikh; Chad Haldeman-Englert; Elizabeth A Geiger; Chris P Ponting; Caleb Webber
Genes and biological processes commonly disrupted in rare and heterogeneous developmental delay syndromes.
Human molecular genetics 2011;20(5):880-93.
2011: Ana C Marques; Jennifer Tan; Chris P Ponting
Wrangling for microRNAs provokes much crosstalk.
Genome biology 2011;12(11):132.
2011: Emily S W Wong; Jane C Fenelon; Richard A Gibbs; Andreas Heger; Arthur L Hsu; Robert D Miller; Anthony T Papenfuss; Chris P Ponting; Marilyn B Renfree; Katherine Belov
Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby.
BMC genomics 2011;12():420.
2011: Matthew K Fujita; Scott V Edwards; Chris P Ponting
The Anolis lizard genome: an amniote genome without isochores.
Genome biology and evolution 2011;3():974-84.
2011: Helen J Blair; Stuart Tompson; Yu-Ning Liu; Jennifer Campbell; Katie MacArthur; Chris P Ponting; Victor L Ruiz-Perez; Judith A Goodship
Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus.
BMC biology 2011;9():14.
2011: Kevin Coward; Chris P Ponting; Nan Zhang; Claire Young; Chang-Jen Huang; Chih-Ming Chou; Junaid Kashir; Rafael A Fissore; John Parrington
Identification and functional analysis of an ovarian form of the egg activation factor phospholipase C zeta (PLCζ) in pufferfish.
Molecular reproduction and development 2011;78(1):48-56.
2010: Eris Duro; Cecilia Lundin; Katrine Ask; Luis Sanchez-Pulido; Thomas J MacArtney; Rachel Toth; Chris P Ponting; Anja Groth; Thomas Helleday; John Rouse
Identification of the MMS22L-TONSL complex that promotes homologous recombination.
Molecular cell 2010;40(4):632-44.
2010: Chris P Ponting; T Grant Belgard
Transcribed dark matter: meaning or myth?
Human molecular genetics 2010;19(R2):R162-8.
2010: Sreeram V Ramagopalan; Andreas Heger; Antonio J Berlanga; Narelle J Maugeri; Matthew R Lincoln; Amy Burrell; Lahiru Handunnetthi; Adam E Handel; Giulio Disanto; Sarah M Orton; Corey Watson; Julia M Morahan; Gavin Giovannoni; Chris P Ponting; George C Ebers; Julian C Knight
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.
Genome research 2010;20(10):1352-60.
2010: Stephen Meader; Chris P Ponting; Gerton Lunter
Massive turnover of functional sequence in human and other mammalian genomes.
Genome research 2010;20(10):1335-43.
2010: Shinya Ohta; Jimi-Carlo Bukowski-Wills; Luis Sanchez-Pulido; Flavia de Lima Alves; Laura Wood; Zhuo A Chen; Melpi Platani; Lutz Fischer; Damien F Hudson; Chris P Ponting; Tatsuo Fukagawa; William C Earnshaw; Juri Rappsilber
The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.
Cell 2010;142(5):810-21.
2010: Lesheng Kong; Peter V Lovell; Andreas Heger; Claudio V Mello; Chris P Ponting
Accelerated evolution of PAK3- and PIM1-like kinase gene families in the zebra finch, Taeniopygia guttata.
Molecular biology and evolution 2010;27(8):1923-34.
2010: Luis Sanchez-Pulido; John F X Diffley; Chris P Ponting
Homology explains the functional similarities of Treslin/Ticrr and Sld3.
Current biology : CB 2010;20(12):R509-10.
2010: Ben L Murton; Wee Loong Chin; Chris P Ponting; Laura S Itzhaki
Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.
Journal of molecular biology 2010;398(4):481-8.
2010: Stephen Meader; LaDeana W Hillier; Devin Locke; Chris P Ponting; Gerton Lunter
Genome assembly quality: assessment and improvement using the neutral indel model.
Genome research 2010;20(5):675-84.
2010: Jayne Y Hehir-Kwa; Nienke Wieskamp; Caleb Webber; Rolph Pfundt; Han G Brunner; Christian Gilissen; Bert B A de Vries; Chris P Ponting; Joris Veltman
Accurate distinction of pathogenic from benign CNVs in mental retardation.
PLoS computational biology 2010;6(4):e1000752.
2010: Elizabeth H Bayne; Sharon A White; Alexander Kagansky; Dominika A Bijos; Luis Sanchez-Pulido; Kwang-Lae Hoe; Dong-Uk Kim; Han-Oh Park; Chris P Ponting; Juri Rappsilber; Robin C Allshire
Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity.
Cell 2010;140(5):666-77.
2010: Rebecca A Chodroff; Leo Goodstadt; Tamara M Sirey; Peter L Oliver; Kay E Davies; Eric D Green; Zoltán Molnár; Chris P Ponting
Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes.
Genome biology 2010;11(7):R72.
2010: Kiwoong Nam; Carina Mugal; Benoit Nabholz; Holger Schielzeth; Jochen B W Wolf; Niclas Backström; Axel Künstner; Christopher N Balakrishnan; Andreas Heger; Chris P Ponting; David F Clayton; Hans Ellegren
Molecular evolution of genes in avian genomes.
Genome biology 2010;11(6):R68.
2009: Peter L Oliver; Leo Goodstadt; Joshua J Bayes; Zoë Birtle; Kevin C Roach; Nitin Phadnis; Scott A Beatson; Gerton Lunter; Harmit Malik; Chris P Ponting
Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.
PLoS genetics 2009;5(12):e1000753.
2009: Guillaume M Hautbergue; Ming-Lung Hung; Matthew J Walsh; Ambrosius Snijders; Chung-Te Chang; Rachel Jones; Chris P Ponting; Mark J Dickman; Stuart A Wilson
UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.
Current biology : CB 2009;19(22):1918-24.
2009: Jasmina Ponjavic; Peter L Oliver; Gerton Lunter; Chris P Ponting
Genomic and transcriptional co-localization of protein-coding and long non-coding RNA pairs in the developing brain.
PLoS genetics 2009;5(8):e1000617.
2009: Chris P Ponting; Leo Goodstadt
Separating derived from ancestral features of mouse and human genomes.
Biochemical Society transactions 2009;37(Pt 4):734-9.
2009: Andreas Heger; Chris P Ponting; Ian Holmes
Accurate estimation of gene evolutionary rates using XRATE, with an application to transmembrane proteins.
Molecular biology and evolution 2009;26(8):1715-21.
2009: Ivan M Muñoz; Karolina Hain; Anne-Cécile Déclais; Mary Gardiner; Geraldine W Toh; Luis Sanchez-Pulido; Johannes M Heuckmann; Rachel Toth; Thomas Macartney; Berina Eppink; Roland Kanaar; Chris P Ponting; David M J Lilley; John Rouse
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
Molecular cell 2009;35(1):116-27.
2009: Luis Sanchez-Pulido; Alison L Pidoux; Chris P Ponting; Robin C Allshire
Common ancestry of the CENP-A chaperones Scm3 and HJURP.
Cell 2009;137(7):1173-4.
2009: Caleb Webber; Jayne Y Hehir-Kwa; Duc-Quang Nguyen; Bert B A de Vries; Joris Veltman; Chris P Ponting
Forging links between human mental retardation-associated CNVs and mouse gene knockout models.
PLoS genetics 2009;5(6):e1000531.
2009: Chris P Ponting; Peter L Oliver; Wolf Reik
Evolution and functions of long noncoding RNAs.
Cell 2009;136(4):629-41.
2009: Ana C Marques; Chris P Ponting
Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness.
Genome biology 2009;10(11):R124.
2008: Mai M Abd El-Aziz; Isabel Barragan; Ciara A O'Driscoll; Leo Goodstadt; Elena Prigmore; Salud Borrego; Marcela Mena; Juan I Pieras; Mohamed F El-Ashry; Leen Abu Safieh; Amna Shah; Michael Cheetham; Nigel P Carter; Christina F Chakarova; Chris P Ponting; Shomi S Bhattacharya; Guillermo Antinolo
EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa.
Nature genetics 2008;40(11):1285-7.
2008: Duc-Quang Nguyen; Caleb Webber; Jayne Hehir-Kwa; Rolph Pfundt; Joris Veltman; Chris P Ponting
Reduced purifying selection prevails over positive selection in human copy number variant evolution.
Genome research 2008;18(11):1711-23.
2008: Camilla M Whittington; Anthony T Papenfuss; Paramjit S Bansal; Allan M Torres; Emily Wong; Janine Deakin; Tina Graves; Amber E Alsop; Kyriena Schatzkamer; Colin Kremitzki; Chris P Ponting; Peter Temple-Smith; Wesley C Warren; Philip W Kuchel; Katherine Belov
Defensins and the convergent evolution of platypus and reptile venom genes.
Genome research 2008;18(6):986-94.
2008: Preeti Bakrania; Maria Efthymiou; Johannes C Klein; Alison Salt; David J Bunyan; Alex Wyatt; Chris P Ponting; Angela Martin; Steven Williams; Victoria Lindley; Joanne Gilmore; Marie Restori; Anthony G Robson; Magella Neveu; Graham Holder; J R O Collin; David O Robinson; Peter Farndon; Heidi Johansen-Berg; Dianne Gerrelli; Nicola K Ragge
Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways.
American journal of human genetics 2008;82(2):304-19.
2008: Christina Marie Laukaitis; Andreas Heger; Tyler D Blakley; Pavel Munclinger; Chris P Ponting; Robert C Karn
Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals.
BMC evolutionary biology 2008;8():46.
2008: Steven A Ramm; Peter L Oliver; Chris P Ponting; Paula Stockley; Richard Emes
Sexual selection and the adaptive evolution of mammalian ejaculate proteins.
Molecular biology and evolution 2008;25(1):207-19.
2008: Andreas Heger; Chris P Ponting
OPTIC: orthologous and paralogous transcripts in clades.
Nucleic acids research 2008;36(Database issue):D267-70.
2007: Andreas Heger; Chris P Ponting
Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes.
Genome research 2007;17(12):1837-49.
2007: Thomas Gerken; Christophe A Girard; Yi-Chun Loraine Tung; Celia J Webby; Vladimir Saudek; Kirsty S Hewitson; Giles S H Yeo; Michael McDonough; Sharon Cunliffe; Luke A McNeill; Juris Galvanovskis; Patrik Rorsman; Peter Robins; Xavier Prieur; Anthony P Coll; Marcella Ma; Zorica Jovanovic; I Sadaf Farooqi; Barbara Sedgwick; Inês Barroso; Tomas Lindahl; Chris P Ponting; Frances M Ashcroft; Stephen O'Rahilly; Christopher J Schofield
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Science (New York, N.Y.) 2007;318(5855):1469-72.
2007: Andreas Heger; Chris P Ponting
Variable strength of translational selection among 12 Drosophila species.
Genetics 2007;177(3):1337-48.
2007: Jasmina Ponjavic; Chris P Ponting
The long and the short of RNA maps.
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(11):1077-80.
2007: Christina F Chakarova; Mary Papaioannou; Hemant Khanna; Irma Lopez; Naushin Waseem; Amna Shah; Torsten Theis; James Friedman; Cécilia Maubaret; Kinga Bujakowska; Brotati Veraitch; Mai M Abd El-Aziz; De Quincy Prescott; Sunil K Parapuram; Wendy A Bickmore; Peter M G Munro; Andreas Gal; Christian P Hamel; Valeria Marigo; Chris P Ponting; Bernd Wissinger; Eberhart Zrenner; Karl Matter; Anand Swaroop; Robert K Koenekoop; Shomi S Bhattacharya
Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy.
American journal of human genetics 2007;81(5):1098-103.
2007: Leo Goodstadt; Andreas Heger; Caleb Webber; Chris P Ponting
An analysis of the gene complement of a marsupial, Monodelphis domestica: evolution of lineage-specific genes and giant chromosomes.
Genome research 2007;17(7):969-81.
2007: Jasmina Ponjavic; Chris P Ponting; Gerton Lunter
Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs.
Genome research 2007;17(5):556-65.
2006: Zoë Birtle; Chris P Ponting
Meisetz and the birth of the KRAB motif.
Bioinformatics (Oxford, England) 2006;22(23):2841-5.
2006: Chris P Ponting; Gerton Lunter
Signatures of adaptive evolution within human non-coding sequence.
Human molecular genetics 2006;15 Spec No 2():R170-5.
2006: Leo Goodstadt; Chris P Ponting
Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and human.
PLoS computational biology 2006;2(9):e133.
2006: Chris P Ponting; Gerton Lunter
Evolutionary biology: human brain gene wins genome race.
Nature 2006;443(7108):149-50.
2006: Frank S Cordes; Peter Kraiczy; Pietro Roversi; Markus M Simon; Volker Brade; Oliver Jahraus; Russell Wallis; Leo Goodstadt; Chris P Ponting; Christine Skerka; Peter F Zipfel; Reinhard Wallich; Susan M Lea
Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi.
International journal of medical microbiology : IJMM 2006;296 Suppl 40():177-84.
2006: Chris P Ponting
A novel domain suggests a ciliary function for ASPM, a brain size determining gene.
Bioinformatics (Oxford, England) 2006;22(9):1031-5.
2006: Tom D Bunney; Richard Harris; Natalia Lamuño Gandarillas; Michelle Josephs; S Mark Roe; S Caroline Sorli; Hugh F Paterson; Fernando Rodrigues-Lima; Diego Esposito; Chris P Ponting; Peter Gierschik; Laurence H Pearl; Paul C Driscoll; Matilda Katan
Structural and mechanistic insights into ras association domains of phospholipase C epsilon.
Molecular cell 2006;21(4):495-507.
2006: Duc-Quang Nguyen; Caleb Webber; Chris P Ponting
Bias of selection on human copy-number variants.
PLoS genetics 2006;2(2):e20.
2006: Gerton Lunter; Chris P Ponting; Jotun Hein
Genome-wide identification of human functional DNA using a neutral indel model.
PLoS computational biology 2006;2(1):e5.
2005: Caleb Webber; Chris P Ponting
Hotspots of mutation and breakage in dog and human chromosomes.
Genome research 2005;15(12):1787-97.
2005: Chris P Ponting; Andrew P Jackson
Evolution of primary microcephaly genes and the enlargement of primate brains.
Current opinion in genetics & development 2005;15(3):241-8.
2005: Eitan E Winter; Chris P Ponting
Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.
BMC evolutionary biology 2005;5():54.
2005: Zoë Birtle; Leo Goodstadt; Chris P Ponting
Duplication and positive selection among hominin-specific PRAME genes.
BMC genomics 2005;6():120.
2005: Christina Marie Laukaitis; Stephen R Dlouhy; Richard Emes; Chris P Ponting; Robert C Karn
Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus.
BMC evolutionary biology 2005;5():40.
2004: Scott A Beatson; Chris P Ponting
GIFT domains: linking eukaryotic intraflagellar transport and glycosylation to bacterial gliding.
Trends in biochemical sciences 2004;29(8):396-9.
2004: Richard Emes; Matthew C Riley; Christina Marie Laukaitis; Leo Goodstadt; Robert C Karn; Chris P Ponting
Comparative evolutionary genomics of androgen-binding protein genes.
Genome research 2004;14(8):1516-29.
2004: Leo Goodstadt; Chris P Ponting
Vitamin K epoxide reductase: homology, active site and catalytic mechanism.
Trends in biochemical sciences 2004;29(6):289-92.
2004: Caleb Webber; Chris P Ponting
Genes and homology.
Current biology : CB 2004;14(9):R332-3.
2004: Richard Emes; Scott A Beatson; Chris P Ponting; Leo Goodstadt
Evolution and comparative genomics of odorant- and pheromone-associated genes in rodents.
Genome research 2004;14(4):591-602.
2004: Martin Taylor; Chris P Ponting; Richard R Copley
Occurrence and consequences of coding sequence insertions and deletions in Mammalian genomes.
Genome research 2004;14(4):555-66.
2004: Heike Zimdahl; Gerald Nyakatura; Petra Brandt; Herbert Schulz; Oliver Hummel; Berthold Fartmann; David Brett; Marcus Droege; Jan Monti; Young-Ae Lee; Yinyan Sun; Shaying Zhao; Eitan E Winter; Chris P Ponting; Yuan Chen; Arek Kasprzyk; Ewan Birney; Detlev Ganten; Norbert Hubner
A SNP map of the rat genome generated from cDNA sequences.
Science (New York, N.Y.) 2004;303(5659):807.
2004: Hui Huang; Eitan E Winter; Huajun Wang; Keith G Weinstock; Heming Xing; Leo Goodstadt; Peter D Stenson; David N Cooper; Douglas Smith; M Mar Albà; Chris P Ponting; Kim Fechtel
Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes.
Genome biology 2004;5(7):R47.
2004: Eitan E Winter; Leo Goodstadt; Chris P Ponting
Elevated rates of protein secretion, evolution, and disease among tissue-specific genes.
Genome research 2004;14(1):54-61.
2004: Ivica Letunic; Richard R Copley; Steffen Schmidt; Francesca D Ciccarelli; Tobias Doerks; Jörg Schultz; Chris P Ponting; Peer Bork
SMART 4.0: towards genomic data integration.
Nucleic acids research 2004;32(Database issue):D142-4.
2003: Richard R Copley; Leo Goodstadt; Chris P Ponting
Eukaryotic domain evolution inferred from genome comparisons.
Current opinion in genetics & development 2003;13(6):623-8.
2003: Luke Hughes-Davies; David Huntsman; Margarida Ruas; François Fuks; Jacqueline Bye; Suet-Feung Chin; Jonathon Milner; Lindsay A Brown; Forrest Hsu; Blake Gilks; Torsten Nielsen; Michael Schulzer; Stephen Chia; Joseph Ragaz; Anthony Cahn; Lori Linger; Hilal Ozdag; Elena Cattaneo; Ekaterina S. Jordanova; Edward Schuuring; David S Yu; Ashok R Venkitaraman; Bruce A J Ponder; Aidan Doherty; Samuel A J R Aparicio; David Bentley; Charles Theillet; Chris P Ponting; Carlos Caldas; Tony Kouzarides
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Cell 2003;115(5):523-35.
2003: Maxine Allen; Andrea Heinzmann; Emiko Noguchi; Goncalo Abecasis; John Broxholme; Chris P Ponting; Sumit Bhattacharyya; Jon Tinsley; Youming Zhang; Richard Holt; E Yvonne Jones; Nicholas J Lench; Alisoun Carey; Helene Jones; Nicholas J Dickens; Claire Dimon; Rosie Nicholls; Crystal Baker; Luzheng Xue; Elizabeth Townsend; Michael Kabesch; Stephan K Weiland; David Carr; Erika von Mutius; Ian M Adcock; Peter J Barnes; G Mark Lathrop; Mark Edwards; Miriam F Moffatt; William O C M Cookson
Positional cloning of a novel gene influencing asthma from chromosome 2q14.
Nature genetics 2003;35(3):258-63.
2003: J D Vargas; B Herpers; A T McKie; S Gledhill; J McDonnell; Marcel van den Heuvel; Kay E Davies; Chris P Ponting
Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases.
Biochimica et biophysica acta 2003;1651(1-2):116-23.
2003: Lee Smith; Nick Van Hateren; John Willan; Rosario Romero; Gonzalo Blanco; Pam Siggers; James Walsh; Ruby Banerjee; Paul Denny; Chris P Ponting; Andy Greenfield
Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein.
Developmental dynamics : an official publication of the American Association of Anatomists 2003;227(4):600-7.
2003: Youming Zhang; Nicholas I Leaves; Gavin G Anderson; Chris P Ponting; John Broxholme; Richard Holt; Pauline Edser; Sumit Bhattacharyya; Andy Dunham; Ian M Adcock; Louise Pulleyn; Peter J Barnes; John I Harper; Goncalo Abecasis; Lon Cardon; Melanie White; John Burton; Lucy Matthews; Richard Mott; Mark Ross; Roger Cox; Miriam F Moffatt; William O C M Cookson
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.
Nature genetics 2003;34(2):181-6.
2003: Rasmus Hartmann-Petersen; Colin Semple; Chris P Ponting; Klavs B Hendil; Colin Gordon
UBA domain containing proteins in fission yeast.
The international journal of biochemistry & cell biology 2003;35(5):629-36.
2003: Richard Emes; Leo Goodstadt; Eitan E Winter; Chris P Ponting
Comparison of the genomes of human and mouse lays the foundation of genome zoology.
Human molecular genetics 2003;12(7):701-9.
2003: Roderic Guigo; Emmanouil T Dermitzakis; Pankaj Agarwal; Chris P Ponting; Genís Parra; Alexandre Reymond; Josep F Abril; Evan Keibler; Robert Lyle; Catherine Ucla; Stylianos E Antonarakis; Michael R Brent
Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1140-5.
2003: Sebastian Maurer-Stroh; Nicholas J Dickens; Luke Hughes-Davies; Tony Kouzarides; Frank Eisenhaber; Chris P Ponting
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
Trends in biochemical sciences 2003;28(2):69-74.
2003: Nicholas J Dickens; Chris P Ponting
THoR: a tool for domain discovery and curation of multiple alignments.
Genome biology 2003;4(8):R52.
2002: J D Vargas; Emmanuel Culetto; Chris P Ponting; Irene Miguel-Aliaga; Kay E Davies; David B Sattelle
Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene.
Mechanisms of development 2002;117(1-2):289-92.
2002: Chris P Ponting
Novel domains and orthologues of eukaryotic transcription elongation factors.
Nucleic acids research 2002;30(17):3643-52.
2002: Richard Mott; Jörg Schultz; Peer Bork; Chris P Ponting
Predicting protein cellular localization using a domain projection method.
Genome research 2002;12(8):1168-74.
2002: Eitan Winter; Chris P Ponting
TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?
Trends in biochemical sciences 2002;27(8):381-3.
2002: Chris P Ponting; Michael Hutton; Andrew C Nyborg; Matthew Baker; Karen Jansen; todd golde
Identification of a novel family of presenilin homologues.
Human molecular genetics 2002;11(9):1037-44.
2002: Nicholas J Dickens; Scott A Beatson; Chris P Ponting
Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins.
Current biology : CB 2002;12(6):R197-9.
2002: Richard R Copley; Chris P Ponting; Jörg Schultz; Peer Bork
Sequence analysis of multidomain proteins: past perspectives and future directions.
Advances in protein chemistry 2002;61():75-98.
2002: Chris P Ponting; Robert R Russell
The natural history of protein domains.
Annual review of biophysics and biomolecular structure 2002;31():45-71.
2002: Chris P Ponting; Takashi Ito; Jorge Moscat; María T Diaz-Meco; Fuyuhiko Inagaki; Hideki Sumimoto
OPR, PC and AID: all in the PB1 family.
Trends in biochemical sciences 2002;27(1):10.
2002: Tobias Doerks; Richard R Copley; Jörg Schultz; Chris P Ponting; Peer Bork
Systematic identification of novel protein domain families associated with nuclear functions.
Genome research 2002;12(1):47-56.
2002: Ivica Letunic; Leo Goodstadt; Nicholas J Dickens; Tobias Doerks; Jörg Schultz; Richard Mott; Francesca D Ciccarelli; Richard R Copley; Chris P Ponting; Peer Bork
Recent improvements to the SMART domain-based sequence annotation resource.
Nucleic acids research 2002;30(1):242-4.
2001: Chris P Ponting; Richard Mott; P Bork; Richard R Copley
Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution.
Genome research 2001;11(12):1996-2008.
2001: Martin Brockington; Derek J Blake; Paola Prandini; Susan C Brown; Silvia Torelli; Matthew A Benson; Chris P Ponting; Brigitte Estournet; Norma B Romero; Eugenio Mercuri; Thomas Voit; Caroline A Sewry; Pascale Guicheney; Francesco Muntoni
Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan.
American journal of human genetics 2001;69(6):1198-209.
2001: Richard Emes; Chris P Ponting
A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration.
Human molecular genetics 2001;10(24):2813-20.
2001: Leo Goodstadt; Chris P Ponting
Sequence variation and disease in the wake of the draft human genome.
Human molecular genetics 2001;10(20):2209-14.
2001: Leo Goodstadt; Chris P Ponting
CHROMA: consensus-based colouring of multiple alignments for publication.
Bioinformatics (Oxford, England) 2001;17(9):845-6.
2001: Chris P Ponting
Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?
Human molecular genetics 2001;10(17):1853-8.
2001: Miguel Andrade; Carol Perez-Iratxeta; Chris P Ponting
Protein repeats: structures, functions, and evolution.
Journal of structural biology 2001;134(2-3):117-31.
2001: Sarah E Newey; Emily V Howman; Chris P Ponting; Matthew A Benson; RA Nawrotzki; Nellie Y Loh; Kay E Davies; Derek J Blake
Syncoilin, a novel member of the intermediate filament superfamily that interacts with alpha-dystrobrevin in skeletal muscle.
The Journal of biological chemistry 2001;276(9):6645-55.
2001: Chris P Ponting; N J Dickens
Genome cartography through domain annotation.
Genome biology 2001;2(7):Comment 2006.
2001: P M Clissold; Chris P Ponting
JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta.
Trends in biochemical sciences 2001;26(1):7-9.
2000: P M Clissold; Chris P Ponting
PIN domains in nonsense-mediated mRNA decay and RNAi.
Current biology : CB 2000;10(24):R888-90.
2000: Sarah E Newey; Matthew A Benson; Chris P Ponting; Kay E Davies; Derek J Blake
Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex.
Current biology : CB 2000;10(20):1295-8.
2000: Chris P Ponting; R B Russell
Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteins.
Journal of molecular biology 2000;302(5):1041-7.
2000: Chris P Ponting
Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay.
Trends in biochemical sciences 2000;25(9):423-6.
2000: Miguel Andrade; Chris P Ponting; Toby J Gibson; Peer Bork
Homology-based method for identification of protein repeats using statistical significance estimates.
Journal of molecular biology 2000;298(3):521-37.
2000: Matthew N Hodgkin; M R Masson; Dale J Powner; KM Saqib; Chris P Ponting; Michael J O Wakelam
Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-specific PH domain.
Current biology : CB 2000;10(1):43-6.
1999: Payam Mohaghegh; NR Rodrigues; N Owen; Chris P Ponting; Thanh T Le; Arthur H M Burghes; Kay E Davies
Analysis of mutations in the tudor domain of the survival motor neuron protein SMN.
European journal of human genetics : EJHG 1999;7(5):519-25.
1999: Andrew P May; Chris P Ponting
Integrin alpha- and beta 4-subunit-domain homologues in cyanobacterial proteins.
Trends in biochemical sciences 1999;24(1):12-3.
1999: Chris P Ponting; J Schultz; F Milpetz; P Bork
SMART: identification and annotation of domains from signalling and extracellular protein sequences.
Nucleic acids research 1999;27(1):229-32.
1998: Kevin Talbot; Irene Miguel-Aliaga; Payam Mohaghegh; Chris P Ponting; Kay E Davies
Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex.
Human molecular genetics 1998;7(13):2149-56.
1998: J Schultz; F Milpetz; Peer Bork; Chris P Ponting
SMART, a simple modular architecture research tool: identification of signaling domains.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):5857-64.
1998: E Schröder; A C Willis; Chris P Ponting
Porcine natural-killer-enhancing factor-B: oligomerisation and identification as a calpain substrate in vitro.
Biochimica et biophysica acta 1998;1383(2):279-91.
1997: Chris P Ponting; C Phillips; K E Davies; D J Blake
PDZ domains: targeting signalling molecules to sub-membranous sites.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(6):469-79.
1997: Chris P Ponting; J Schultz; P Bork
SPRY domains in ryanodine receptors (Ca(2+)-release channels).
Trends in biochemical sciences 1997;22(6):193-4.
1997: Kevin Talbot; Chris P Ponting; AM Theodosiou; NR Rodrigues; R Surtees; R Mountford; Kay E Davies
Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism?
Human molecular genetics 1997;6(3):497-500.
1997: Chris P Ponting
Tudor domains in proteins that interact with RNA.
Trends in biochemical sciences 1997;22(2):51-2.