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Robin Poole

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H Yoshida; Hajime Hanamura; M Kojima; Toshihisa Kojima; K Kurokouchi; A Robin Poole; S Takahashi; Naoki Ishiguro
Relationship between pre-radiographic cartilage damage following anterior cruciate ligament injury and biomarkers of cartilage turnover in clinical practice: a cross-sectional observational study.
Mary Connolly; Barry Bresnihan; Oliver FitzGerald; Aisling Kennedy; Clare Matthews; Jennifer McCormick; Ronan H Mullan; A Robin Poole; Owen Sullivan; douglas veale; Ursula Fearon
Acute-phase serum amyloid A regulates tumor necrosis factor α and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy.
A Robin Poole
Osteoarthritis as a whole joint disease.

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2013: H Yoshida; Hajime Hanamura; M Kojima; Toshihisa Kojima; K Kurokouchi; A Robin Poole; S Takahashi; Naoki Ishiguro
Relationship between pre-radiographic cartilage damage following anterior cruciate ligament injury and biomarkers of cartilage turnover in clinical practice: a cross-sectional observational study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2013;21(6):831-8.
2012: Mary Connolly; Barry Bresnihan; Oliver FitzGerald; Aisling Kennedy; Clare Matthews; Jennifer McCormick; Ronan H Mullan; A Robin Poole; Owen Sullivan; douglas veale; Ursula Fearon
Acute-phase serum amyloid A regulates tumor necrosis factor α and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy.
Arthritis and rheumatism 2012;64(4):1035-45.
2012: A Robin Poole
Osteoarthritis as a whole joint disease.
HSS journal : the musculoskeletal journal of Hospital for Special Surgery 2012;8(1):4-6.
2012: Valeria M Dejica; Sheila Laverty; John S Mort; Michael Tanzer; David J Zukor; John Antoniou; A Robin Poole
Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage.
Arthritis research & therapy 2012;14(3):R113.
2011: A Robin Poole
What do measurements of molecular biomarkers in different body fluids really tell us?
Arthritis research & therapy 2011;13(2):110.
2010: F Kempta Lekpa; J C Piette; Sylvie Bastuji-Garin; V B Kraus; T V Stabler; A Robin Poole; A Marini-Portugal; Xavier Chevalier
Serum cartilage oligomeric matrix protein (COMP) level is a marker of disease activity in relapsing polychondritis.
Clinical and experimental rheumatology 2010;28(4):553-5.
2010: R Clark Billinghurst; Mirela Ionescu; A Robin Poole
Immunoassays for collagenase-mediated cleavage of type I and II collagens.
Methods in molecular biology (Clifton, N.J.) 2010;622():349-66.
2009: Jolanda Cibere; Hongbin Zhang; Patrick Garnero; A Robin Poole; Tatiana Lobanok; Tore Saxne; Virginia B Kraus; Amanda Way; Anona Thorne; Hubert Wong; Joel Singer; Jacek A Kopec; Ali Guermazi; Charles Peterfy; Savvas Nicolaou; Peter L Munk; John M Esdaile
Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study.
Arthritis and rheumatism 2009;60(5):1372-80.
2008: Valeria M Dejica; John S Mort; Sheila Laverty; Michael Percival; John Antoniou; David J Zukor; A Robin Poole
Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage.
The American journal of pathology 2008;173(1):161-9.
2008: Thierry Conrozier; A Robin Poole; F Ferrand; Pierre Marie MATHIEU; F Vincent; Muriel Piperno; Catherine Verret; M Ionescu; Eric Vignon
Serum concentrations of type II collagen biomarkers (C2C, C1, 2C and CPII) suggest different pathophysiologies in patients with hip osteoarthritis.
Clinical and experimental rheumatology 2008;26(3):430-5.
2008: Toshihisa Kojima; Masayo Kojima; Kazuya Noda; Naoki Ishiguro; A Robin Poole
Influences of menopause, aging, and gender on the cleavage of type II collagen in cartilage in relationship to bone turnover.
Menopause (New York, N.Y.) 2008;15(1):133-7.
2007: Ronan H Mullan; Clare Matthews; Barry Bresnihan; Oliver FitzGerald; Lindsay King; A Robin Poole; Ursula Fearon; douglas veale
Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy.
Arthritis and rheumatism 2007;56(9):2919-28.
2007: September Cahue; Leena Sharma; Dorothy Dunlop; Mirela Ionescu; Jing Song; Tatiana Lobanok; Lindsay King; A Robin Poole
The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(7):819-23.
2007: Walter P Maksymowych; Robert Landewé; Barbara Conner-spady; Maxime Dougados; Herman Mielants; Hille van der Tempel; A Robin Poole; Nandi Wang; Désirée van der Heijde
Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis.
Arthritis and rheumatism 2007;56(6):1846-53.
2007: Elena V Tchetina; Masahiko Kobayashi; Tadashi Yasuda; Tineke Meijers; Isabelle Pidoux; A Robin Poole
Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(4):247-58.
2007: Thierry Conrozier; F Ferrand; A Robin Poole; Catherine Verret; Pierre Marie MATHIEU; M Ionescu; F Vincent; Muriel Piperno; A Spiegel; Eric Vignon
Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(4):462-7.
2007: Elena V Tchetina; John A Di Battista; David J Zukor; John Antoniou; A Robin Poole
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.
Arthritis research & therapy 2007;9(4):R75.
2006: Ursula Fearon; Ronan H Mullan; Trevor Markham; Mary Connolly; Shane Sullivan; A Robin Poole; Oliver FitzGerald; Barry Bresnihan; douglas veale
Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
Arthritis and rheumatism 2006;54(10):3152-62.
2006: Tadashi Yasuda; Elena V Tchetina; Kunitaka Ohsawa; Peter J Roughley; William Wu; Aisha Mousa; Mirela Ionescu; Isabelle Pidoux; A Robin Poole
Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(7):419-29.
2006: Steven A Mazzuca; A Robin Poole; Kenneth D Brandt; Barry P Katz; Kathleen A Lane; Tatiana Lobanok
Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis.
The Journal of rheumatology 2006;33(6):1147-51.
2006: Gladys Valverde-Franco; Jean-Sébastien Binette; W Li; H Wang; Sen Chai; F Laflamme; Nicolas Tran-Khanh; E Quenneville; Tineke Meijers; A Robin Poole; John S Mort; Michael D Buschmann; Janet E Henderson
Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice.
Human molecular genetics 2006;15(11):1783-92.
2006: A Robin Poole
Biologic markers and disc degeneration.
The Journal of bone and joint surgery. American volume 2006;88 Suppl 2():72-5.
2006: Fred RT Nelson; R Clark Billinghurst; Isabelle Pidoux; Agnes Reiner; M Langworthy; M McDermott; T Malogne; D F Sitler; N R Kilambi; E Lenczner; A Robin Poole
Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(2):114-9.
2006: Elena V Tchetina; John Antoniou; Michael Tanzer; David J Zukor; A Robin Poole
Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production.
The American journal of pathology 2006;168(1):131-40.
2006: Matthias Aurich; Fackson Mwale; Agnes Reiner; Juergen Mollenhauer; Jens O Anders; Reneé A Fuhrmann; Klaus E Kuettner; A Robin Poole; Ada A Cole
Collagen and proteoglycan turnover in focally damaged human ankle cartilage: evidence for a generalized response and active matrix remodeling across the entire joint surface.
Arthritis and rheumatism 2006;54(1):244-52.
2005: Walter P Maksymowych; A Robin Poole; Lori Hiebert; Alison Webb; Mirela Ionescu; Tatiana Lobanok; Lindsay King; John C Davis
Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis.
The Journal of rheumatology 2005;32(10):1911-7.
2005: Jolanda Cibere; Anona Thorne; Jacek A Kopec; Joel Singer; Janice Canvin; David B Robinson; Janet Pope; Paul Hong; Eric Grant; Tatiana Lobanok; Mirela Ionescu; A Robin Poole; John M Esdaile
Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: randomized discontinuation trial results employing biomarkers.
The Journal of rheumatology 2005;32(5):896-902.
2005: Elena V Tchetina; Ginette R Squires; A Robin Poole
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
The Journal of rheumatology 2005;32(5):876-86.
2005: Gabrielle Tiraloche; Christiane Girard; Luc Chouinard; John S Sampalis; Luc Moquin; Mirela Ionescu; Agnes Reiner; A Robin Poole; Sheila Laverty
Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis.
Arthritis and rheumatism 2005;52(4):1118-28.
2005: Tae-Hwan Kim; Millicent Stone; Ursula Payne; Xiang Zhang; Mirela Ionescu; Tatiana Lobanok; Lindsay King; A Robin Poole; Robert D Inman
Cartilage biomarkers in ankylosing spondylitis: relationship to clinical variables and treatment response.
Arthritis and rheumatism 2005;52(3):885-91.
2005: Bruce D Beynnon; Benjamin S Uh; Robert J Johnson; Joseph A Abate; Claude E Nichols; Braden C Fleming; A Robin Poole; Harald Roos
Rehabilitation after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind comparison of programs administered over 2 different time intervals.
The American journal of sports medicine 2005;33(3):347-59.
2005: Masahiko Kobayashi; Ginette R Squires; Aisha Mousa; Michael Tanzer; David J Zukor; John Antoniou; Ulrich Feige; A Robin Poole
Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.
Arthritis and rheumatism 2005;52(1):128-35.
2005: Matthias Aurich; Ginette R Squires; Agnes Reiner; Juergen Mollenhauer; Klaus E Kuettner; A Robin Poole; Ada A Cole
Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints.
Arthritis and rheumatism 2005;52(1):112-9.
2005: Kenn Holmbeck; Paolo Bianco; Isabelle Pidoux; S Inoue; R Clark Billinghurst; William Wu; Kali Chrysovergis; Susan Yamada; Henning Birkedal-Hansen; A Robin Poole
The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone.
Journal of cell science 2005;118(Pt 1):147-56.
2004: A Robin Poole; Mirela Ionescu; M A Fitzcharles; R Clark Billinghurst
The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases.
Journal of immunological methods 2004;294(1-2):145-53.
2004: Shuiliang Shi; Suzanne Grothe; Yiping Zhang; Maureen D O'Connor-McCourt; A Robin Poole; Peter J Roughley; John S Mort
Link protein has greater affinity for versican than aggrecan.
The Journal of biological chemistry 2004;279(13):12060-6.
2004: John R Matyas; Lynne M Atley; Mirela Ionescu; David R Eyre; A Robin Poole
Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis.
Arthritis and rheumatism 2004;50(2):543-52.
2004: R Clark Billinghurst; Fackson Mwale; Anthony Hollander; Mirela Ionescu; A Robin Poole
Immunoassays for collagens in chondrocyte and cartilage explant cultures.
Methods in molecular medicine 2004;100():251-74.
2003: Kristen M Clements; Joanne S Price; Mark G Chambers; Denise M Visco; A Robin Poole; Roger M Mason
Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
Arthritis and rheumatism 2003;48(12):3452-63.
2003: Alexander Fraser; Ursula Fearon; R Clark Billinghurst; Mirela Ionescu; Richard Reece; Thomas Barwick; Paul Emery; A Robin Poole; douglas veale
Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.
Arthritis and rheumatism 2003;48(11):3085-95.
2003: A Robin Poole
Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis.
Rheumatic diseases clinics of North America 2003;29(4):803-18.
2003: Shuiliang Shi; Cristina Ciurli; Annie Cartman; Isabelle Pidoux; A Robin Poole; Yiping Zhang
Experimental immunity to the G1 domain of the proteoglycan versican induces spondylitis and sacroiliitis, of a kind seen in human spondylarthropathies.
Arthritis and rheumatism 2003;48(10):2903-15.
2003: Tadashi Yasuda; A Robin Poole; Makoto Shimizu; Takefumi Nakagawa; Sohel M Julovi; Hirokazu Tamamura; Nobutaka Fujii; Takashi Nakamura
Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture.
Arthritis and rheumatism 2003;48(5):1271-80.
2003: Ginette R Squires; Sharon Okouneff; Mirela Ionescu; A Robin Poole
The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis.
Arthritis and rheumatism 2003;48(5):1261-70.
2003: Elena V Tchetina; Fackson Mwale; A Robin Poole
Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(5):844-51.
2003: Fackson Mwale; Caroline N Demers; Alain Petit; Peter J Roughley; A Robin Poole; Thomas Steffen; Max Aebi; John Antoniou
A synthetic peptide of link protein stimulates the biosynthesis of collagens II, IX and proteoglycan by cells of the intervertebral disc.
Journal of cellular biochemistry 2003;88(6):1202-13.
2003: Richard L Leff; Ileana Elias; Mirela Ionescu; Agnes Reiner; A Robin Poole
Molecular changes in human osteoarthritic cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase inhibitor.
The Journal of rheumatology 2003;30(3):544-9.
2003: A Robin Poole; Fred RT Nelson; Leif Dahlberg; Elena V Tchetina; Masahiko Kobayashi; Tadashi Yasuda; Sheila Laverty; Ginette R Squires; Toshihisa Kojima; William Wu; R Clark Billinghurst
Proteolysis of the collagen fibril in osteoarthritis.
Biochemical Society symposium 2003;(70):115-23.
2003: A Robin Poole
What type of cartilage repair are we attempting to attain?
The Journal of bone and joint surgery. American volume 2003;85-A Suppl 2():40-4.
2002: Yiping Zhang; Shuilang Shi; Christina Ciurli; A Robin Poole
Animal models of ankylosing spondylitis.
Current rheumatology reports 2002;4(6):507-12.
2002: Naoki Ishiguro; Toshihisa Kojima; A Robin Poole
Mechanism of cartilage destruction in osteoarthritis.
Nagoya journal of medical science 2002;65(3-4):73-84.
2002: Sheila Laverty; S Okouneff; Mirela Ionescu; Agnes Reiner; Isabelle Pidoux; C Webber; Yves Rossier; R Clark Billinghurst; A Robin Poole
Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(6):1282-9.
2002: Marc M Thibault; A Robin Poole; Michael D Buschmann
Cyclic compression of cartilage/bone explants in vitro leads to physical weakening, mechanical breakdown of collagen and release of matrix fragments.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(6):1265-73.
2002: Matthias Aurich; A Robin Poole; Agnes Reiner; Christine Mollenhauer; Arkady Margulis; Klaus E Kuettner; Ada A Cole
Matrix homeostasis in aging normal human ankle cartilage.
Arthritis and rheumatism 2002;46(11):2903-10.
2002: A Robin Poole; Masahiko Kobayashi; Tadashi Yasuda; Sheila Laverty; Fackson Mwale; Toshihisa Kojima; T Sakai; C Wahl; Sherif El-Maadawy; G Webb; Elena V Tchetina; William Wu
Type II collagen degradation and its regulation in articular cartilage in osteoarthritis.
Annals of the rheumatic diseases 2002;61 Suppl 2():ii78-81.
2002: A Robin Poole
Can serum biomarker assays measure the progression of cartilage degeneration in osteoarthritis?
Arthritis and rheumatism 2002;46(10):2549-52.
2002: Q Chu; M Lopez; K Hayashi; Mirela Ionescu; R Clark Billinghurst; KA Johnson; A Robin Poole; Mark D Markel
Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(8):662-9.
2002: William Wu; R Clark Billinghurst; Isabelle Pidoux; John Antoniou; David J Zukor; Michael Tanzer; A Robin Poole
Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13.
Arthritis and rheumatism 2002;46(8):2087-94.
2002: William Wu; Elena V Tchetina; Fackson Mwale; Karen Hasty; Isabelle Pidoux; Agnes Reiner; Jeffrey Chen; Harold E Van Wart; A Robin Poole
Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(4):639-51.
2002: Aernout Luttun; Florea Lupu; Erik Storkebaum; Marc F Hoylaerts; Lieve Moons; James Crawley; Françoise Bono; A Robin Poole; Peter Tipping; Jean-Marc Herbert; Désiré Collen; Peter Carmeliet
Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):499-505.
2002: J S Price; Mark G Chambers; A Robin Poole; A Fradin; Roger M Mason
Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR/ort model of osteoarthritis and in collagen-induced arthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(3):172-9.
2002: Fackson Mwale; Elena V Tchetina; William Wu; A Robin Poole
The assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens II and IX and proteoglycan.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(2):275-83.
2002: Tadashi Yasuda; A Robin Poole
A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathway.
Arthritis and rheumatism 2002;46(1):138-48.
2001: Naoki Ishiguro; T Ito; T Oguchi; Toshihisa Kojima; Hisashi Iwata; M Ionescu; A Robin Poole
Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis.
Arthritis and rheumatism 2001;44(11):2503-11.
2001: reinout stoop; Pieter Buma; Peter van der Kraan; A P Hollander; R C Billinghurst; Tineke Meijers; A Robin Poole; Wim B van den Berg
Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(4):308-15.
2001: F C Robion; B Doizé; Ludovic P Bouré; Marcel Marcoux; Mirela Ionescu; Agnes Reiner; A Robin Poole; Sheila Laverty
Use of synovial fluid markers of cartilage synthesis and turnover to study effects of repeated intra-articular administration of methylprednisolone acetate on articular cartilage in vivo.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(2):250-8.
2001: Peter van der Kraan; reinout stoop; Tineke Meijers; A Robin Poole; Wim B van den Berg
Expression of type X collagen in young and old C57Bl/6 and Balb/c mice. Relation with articular cartilage degeneration.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):92-100.
2001: William Wu; Fackson Mwale; Elena V Tchetina; Toshihisa Kojima; Tadashi Yasuda; A Robin Poole
Cartilage matrix resorption in skeletogenesis.
Novartis Foundation symposium 2001;232():158-66; discussion 166-70.
2001: R Clark Billinghurst; Mirela Ionescu; A Robin Poole
Immunoassay for collagenase-mediated cleavage of types I and II collagens.
Methods in molecular biology (Clifton, N.J.) 2001;151():457-72.
2001: T Kojima; Fackson Mwale; T Yasuda; C Girard; A Robin Poole; Sheila Laverty
Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis.
Arthritis and rheumatism 2001;44(1):120-7.
2001: L A Neuhold; Loran M Killar; W Zhao; M L Sung; L Warner; John Kulik; J Turner; William Wu; C Billinghurst; Tineke Meijers; A Robin Poole; Philip Babij; Louis J DeGennaro
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.
The Journal of clinical investigation 2001;107(1):35-44.
2000: Fackson Mwale; C Billinghurst; William Wu; Mauro Alini; C Webber; Agnes Reiner; Mirela Ionescu; J Poole; A Robin Poole
Selective assembly and remodelling of collagens II and IX associated with expression of the chondrocyte hypertrophic phenotype.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;218(4):648-62.
2000: Sheila Laverty; Mirela Ionescu; Marcel Marcoux; Ludovic P Bouré; B Doizé; A Robin Poole
Alterations in cartilage type-II procollagen and aggrecan contents in synovial fluid in equine osteochondrosis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(3):399-405.
2000: N L Li; Dong-qing Zhang; K Y Zhou; Annie Cartman; JY Leroux; A Robin Poole; Y P Zhang
Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients.
Cell research 2000;10(1):39-49.
2000: Leif Dahlberg; R Clark Billinghurst; Paul Manner; Fred RT Nelson; G Webb; Mirela Ionescu; Agnes Reiner; Michael Tanzer; David J Zukor; Jeffrey Chen; Harold E Van Wart; A Robin Poole
Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).
Arthritis and rheumatism 2000;43(3):673-82.
2000: R Clark Billinghurst; William Wu; Mirela Ionescu; Agnes Reiner; Leif Dahlberg; Jeffrey Chen; Harold E Van Wart; A Robin Poole
Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase.
Arthritis and rheumatism 2000;43(3):664-72.
1999: Lynne Armstrong; David R Thickett; Jason P Mansell; Mirela Ionescu; E Hoyle; R Clark Billinghurst; A Robin Poole; Ann B Millar
Changes in collagen turnover in early acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 1999;160(6):1910-5.
1999: reinout stoop; Peter van der Kraan; Pieter Buma; A P Hollander; R C Billinghurst; A Robin Poole; Wim B van den Berg
Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice.
Arthritis and rheumatism 1999;42(11):2381-9.
1999: Kenn Holmbeck; Paolo Bianco; John J Caterina; Susan S Yamada; M Kromer; Sergei A Kuznetsov; Mahesh H Mankani; Pamela Robey; A Robin Poole; Isabelle Pidoux; J M Ward; Henning Birkedal-Hansen
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.
Cell 1999;99(1):81-92.
1999: X y Song; L Zeng; Wenwen Jin; J Thompson; Diane Mizel; Ke Jian Lei; R Clark Billinghurst; A Robin Poole; Sharon M Wahl
Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis.
The Journal of experimental medicine 1999;190(4):535-42.
1999: reinout stoop; Peter van der Kraan; Pieter Buma; A P Hollander; A Robin Poole; Wim B van den Berg
Denaturation of type II collagen in articular cartilage in experimental murine arthritis. Evidence for collagen degradation in both reversible and irreversible cartilage damage.
The Journal of pathology 1999;188(3):329-37.
1999: R Clark Billinghurst; K O'Brien; A Robin Poole; Wayne McIlwraith
Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.
Annals of the New York Academy of Sciences 1999;878():594-7.
1999: Robert Sztrolovics; R J White; A Robin Poole; John S Mort; Peter J Roughley
Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.
The Biochemical journal 1999;339 ( Pt 3)():571-7.
1999: David D Frisbie; C S Ray; Mirela Ionescu; A Robin Poole; Phillip L Chapman; Wayne McIlwraith
Measurement of synovial fluid and serum concentrations of the 846 epitope of chondroitin sulfate and of carboxy propeptides of type II procollagen for diagnosis of osteochondral fragmentation in horses.
American journal of veterinary research 1999;60(3):306-9.
1999: L Stefan Lohmander; M Ionescu; H Jugessur; A Robin Poole
Changes in joint cartilage aggrecan after knee injury and in osteoarthritis.
Arthritis and rheumatism 1999;42(3):534-44.
1999: Alexei Guerassimov; Yiping Zhang; Annie Cartman; LC Rosenberg; John M Esdaile; Mary-Ann Fitzcharles; A Robin Poole
Immune responses to cartilage link protein and the G1 domain of proteoglycan aggrecan in patients with osteoarthritis.
Arthritis and rheumatism 1999;42(3):527-33.
1999: J Dumont; M Ionescu; A Reiner; A Robin Poole; Nicolas Tran-Khanh; Caroline D Hoemann; Marc McKee; Michael D Buschmann
Mature full-thickness articular cartilage explants attached to bone are physiologically stable over long-term culture in serum-free media.
Connective tissue research 1999;40(4):259-72.
1999: Naoki Ishiguro; T Ito; H Ito; Hisashi Iwata; H Jugessur; M Ionescu; A Robin Poole
Relationship of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover: analyses of synovial fluid from patients with osteoarthritis.
Arthritis and rheumatism 1999;42(1):129-36.
1998: John Antoniou; G Bruce Pike; Thomas Steffen; HG Baramki; A Robin Poole; Max Aebi; Mauro Alini
Quantitative magnetic resonance imaging in the assessment of degenerative disc disease.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1998;40(6):900-7.
1998: Peter van der Kraan; Elly L Vitters; Tineke Meijers; A Robin Poole; Wim B van den Berg
Collagen type I antisense and collagen type IIA messenger RNA is expressed in adult murine articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(6):417-26.
1998: Yiping Zhang; Alexei Guerassimov; JY Leroux; Annie Cartman; C Webber; R Lalic; E de Miguel; LC Rosenberg; A Robin Poole
Induction of arthritis in BALB/c mice by cartilage link protein: involvement of distinct regions recognized by T and B lymphocytes.
The American journal of pathology 1998;153(4):1283-91.
1998: A Robin Poole
The histopathology of ankylosing spondylitis: are there unifying hypotheses?
The American journal of the medical sciences 1998;316(4):228-33.
1998: Alexei Guerassimov; Yiping Zhang; S Banerjee; Annie Cartman; C Webber; John M Esdaile; Mary-Ann Fitzcharles; A Robin Poole
Autoimmunity to cartilage link protein in patients with rheumatoid arthritis and ankylosing spondylitis.
The Journal of rheumatology 1998;25(8):1480-4.
1998: Alexei Guerassimov; Yiping Zhang; S Banerjee; Annie Cartman; JY Leroux; LC Rosenberg; John M Esdaile; Mary-Ann Fitzcharles; A Robin Poole
Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate.
Arthritis and rheumatism 1998;41(6):1019-25.
1998: Yiping Zhang; Alexei Guerassimov; JY Leroux; Annie Cartman; C Webber; R Lalic; E de Miguel; LC Rosenberg; A Robin Poole
Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice. Evidence for t cell involvement and the immunosuppressive influence of keratan sulfate on recognition of t and b cell epitopes.
The Journal of clinical investigation 1998;101(8):1678-86.
1997: Dennis Carey; Mauro Alini; Mirela Ionescu; J S Hyams; J C Rowe; LC Rosenberg; A Robin Poole
Serum content of the C-propeptide of the cartilage molecule type II collagen in children.
Clinical and experimental rheumatology 1997;15(3):325-8.
1997: Alexei Guerassimov; Ciaran Duffy; Yiping Zhang; S Banerjee; JY Leroux; A Reimann; C Webber; N Delaunay; V Vipparti; L Ronbeck; Annie Cartman; Louise Arsenault; LC Rosenberg; A Robin Poole
Immunity to cartilage link protein in patients with juvenile rheumatoid arthritis.
The Journal of rheumatology 1997;24(5):959-64.
1997: R Clark Billinghurst; Leif Dahlberg; Mirela Ionescu; Agnes Reiner; Robert Bourne; C Rorabeck; P Mitchell; J Hambor; O Diekmann; Harald Tschesche; Jeffrey Chen; Harold E Van Wart; A Robin Poole
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.
The Journal of clinical investigation 1997;99(7):1534-45.
1996: A Robin Poole; LC Rosenberg; Agnes Reiner; Mirela Ionescu; E Bogoch; Peter J Roughley
Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1996;14(5):681-9.
1996: Mauro Alini; A Marriott; T Chen; S Abe; A Robin Poole
A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation.
Developmental biology 1996;176(1):124-32.
1996: John Antoniou; N M Goudsouzian; T F Heathfield; N Winterbottom; Thomas Steffen; A Robin Poole; M Aebi; Mauro Alini
The human lumbar endplate. Evidence of changes in biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration.
Spine 1996;21(10):1153-61.
1996: JY Leroux; Alexei Guerassimov; Annie Cartman; N Delaunay; C Webber; LC Rosenberg; S Banerjee; A Robin Poole
Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo.
The Journal of clinical investigation 1996;97(3):621-32.
1996: Mauro Alini; Y Kofsky; William Wu; I Pidoux; A Robin Poole
In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(1):105-13.
1996: A P Hollander; T F Heathfield; J J Liu; I Pidoux; Peter J Roughley; John S Mort; A Robin Poole
Enhanced denaturation of the alpha (II) chains of type-II collagen in normal adult human intervertebral discs compared with femoral articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1996;14(1):61-6.
1995: A P Hollander; I Pidoux; Agnes Reiner; Cecil H Rorabeck; R Bourne; A Robin Poole
Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.
The Journal of clinical investigation 1995;96(6):2859-69.
1995: A Robin Poole; Fred RT Nelson; A Hollander; Agnes Reiner; I Pidoux; Mirela Ionescu
Collagen II turnover in joint diseases.
Acta orthopaedica Scandinavica. Supplementum 1995;266():88-91.
1995: B Månsson; Dennis Carey; Mauro Alini; Mirela Ionescu; LC Rosenberg; A Robin Poole; D Heinegård; Tore Saxne
Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism.
The Journal of clinical investigation 1995;95(3):1071-7.
1994: Mauro Alini; Dennis Carey; S Hirata; Marc Grynpas; I Pidoux; A Robin Poole
Cellular and matrix changes before and at the time of calcification in the growth plate studied in vitro: arrest of type X collagen synthesis and net loss of collagen when calcification is initiated.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(7):1077-87.
1994: A Robin Poole; Mirela Ionescu; A Swan; Paul Dieppe
Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis.
The Journal of clinical investigation 1994;94(1):25-33.
1994: A P Hollander; T F Heathfield; C Webber; Y Iwata; R Bourne; Cecil H Rorabeck; A Robin Poole
Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.
The Journal of clinical investigation 1994;93(4):1722-32.
1993: J S Mort; G R Dodge; P J Roughley; J Liu; S J Finch; G DiPasquale; A Robin Poole
Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage.
Matrix (Stuttgart, Germany) 1993;13(2):95-102.
1993: Dennis Carey; Mauro Alini; Y Matsui; A Robin Poole
Density gradient separation of growth plate chondrocytes.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1993;29A(2):117-9.
1993: A Robin Poole; G Rizkalla; Mirela Ionescu; Agnes Reiner; E Brooks; C Rorabeck; R Bourne; E Bogoch
Osteoarthritis in the human knee: a dynamic process of cartilage matrix degradation, synthesis and reorganization.
Agents and actions. Supplements 1993;39():3-13.
1992: G Rizkalla; Agnes Reiner; E Bogoch; A Robin Poole
Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease.
The Journal of clinical investigation 1992;90(6):2268-77.
1992: S Banerjee; C Webber; A Robin Poole
The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4+ and CD8+ T cells.
Cellular immunology 1992;144(2):347-57.
1992: M R Rajabi; S Solomon; A Robin Poole
Activation of protein kinase C stimulates collagenase production by cultured cells of the cervix of the pregnant guinea pig.
American journal of obstetrics and gynecology 1992;167(1):194-200.
1992: Mauro Alini; Y Matsui; G R Dodge; A Robin Poole
The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen.
Calcified tissue international 1992;50(4):327-35.
1992: JY Leroux; A Robin Poole; C Webber; V Vipparti; H U Choi; LC Rosenberg; S Banerjee
Characterization of proteoglycan-reactive T cell lines and hybridomas from mice with proteoglycan-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2090-6.
1992: M R Rajabi; E W Quillen; B S Nuwayhid; R Brandt; A Robin Poole
Circulating hyaluronic acid in nonpregnant, pregnant, and postpartum guinea pigs: elevated levels observed at parturition.
American journal of obstetrics and gynecology 1992;166(1 Pt 1):242-6.
1991: G R Dodge; I Pidoux; A Robin Poole
The degradation of type II collagen in rheumatoid arthritis: an immunoelectron microscopic study.
Matrix (Stuttgart, Germany) 1991;11(5):330-8.
1991: M R Rajabi; S Solomon; A Robin Poole
Biochemical evidence of collagenase-mediated collagenolysis as a mechanism of cervical dilatation at parturition in the guinea pig.
Biology of reproduction 1991;45(5):764-72.
1991: Y Matsui; Mauro Alini; C Webber; A Robin Poole
Characterization of aggregating proteoglycans from the proliferative, maturing, hypertrophic, and calcifying zones of the cartilaginous physis.
The Journal of bone and joint surgery. American volume 1991;73(7):1064-74.
1991: M Rajabi; S Solomon; A Robin Poole
Hormonal regulation of interstitial collagenase in the uterine cervix of the pregnant guinea pig.
Endocrinology 1991;128(2):863-71.
1991: M R Rajabi; G R Dodge; S Solomon; A Robin Poole
Immunochemical and immunohistochemical evidence of estrogen-mediated collagenolysis as a mechanism of cervical dilatation in the guinea pig at parturition.
Endocrinology 1991;128(1):371-8.
1990: E Dayer; L Mathai; Tibor T Glant; Katalin Mikecz; A Robin Poole
Cartilage proteoglycan-induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis.
Arthritis and rheumatism 1990;33(9):1394-405.
1990: Katalin Mikecz; Tibor T Glant; Edit Buzás; A Robin Poole
Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice.
Arthritis and rheumatism 1990;33(6):866-76.
1990: A Robin Poole; J Witter; N Roberts; F Piccolo; R Brandt; J Paquin; M Baron
Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of the blood markers hyaluronic acid, orosomucoid, and keratan sulfate.
Arthritis and rheumatism 1990;33(6):790-9.
1990: Eunice R Lee; Y Matsui; A Robin Poole
Immunochemical and immunocytochemical studies of the C-propeptide of type II procollagen in chondrocytes of the growth plate.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990;38(5):659-73.
1990: R G Johnson; A Robin Poole
The early response of articular cartilage to ACL transection in a canine model.
Experimental pathology 1990;38(1):37-52.
1989: A Robin Poole; I Pidoux
Immunoelectron microscopic studies of type X collagen in endochondral ossification.
The Journal of cell biology 1989;109(5):2547-54.
1989: A Robin Poole; C Webber; A Reiner; Peter J Roughley
Studies of a monoclonal antibody to skeletal keratan sulphate. Importance of antibody valency.
The Biochemical journal 1989;260(3):849-56.
1989: A Robin Poole; Y Matsui; A Hinek; Eunice R Lee
Cartilage macromolecules and the calcification of cartilage matrix.
The Anatomical record 1989;224(2):167-79.
1989: A Robin Poole
Honor Bridgett Fell, Ph.D., D.Sc. F.R.S., D.B.E., 1900-1986. The scientist and her contributions.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1989;25(5):450-3.
1989: G R Dodge; A Robin Poole
Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.
The Journal of clinical investigation 1989;83(2):647-61.
1988: A Hinek; A Robin Poole
The influence of vitamin D metabolites on the calcification of cartilage matrix and the C-propeptide of type II collagen (chondrocalcin).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1988;3(4):421-9.
1988: Katalin Mikecz; Tibor T Glant; M Baron; A Robin Poole
Isolation of proteoglycan-specific T lymphocytes from patients with ankylosing spondylitis.
Cellular immunology 1988;112(1):55-63.
1988: A Robin Poole; I Pidoux; Agnes Reiner; Lawrence Rosenberg; D Hollister; L Murray; D Rimoin
Kniest dysplasia is characterized by an apparent abnormal processing of the C-propeptide of type II cartilage collagen resulting in imperfect fibril assembly.
The Journal of clinical investigation 1988;81(2):579-89.
1988: R G Johnson; A Robin Poole
Degenerative changes in dog articular cartilage induced by a unilateral tibial valgus osteotomy.
Experimental pathology 1988;33(3):145-64.
1988: A Robin Poole; Lawrence Rosenberg; L Murray; D Rimoin
Kniest dysplasia: a probable type II collagen defect.
Pathology and immunopathology research 1988;7(1-2):95-8.
1987: C Webber; Tibor T Glant; Peter J Roughley; A Robin Poole
The identification and characterization of two populations of aggregating proteoglycans of high buoyant density isolated from post-natal human articular cartilages of different ages.
The Biochemical journal 1987;248(3):735-40.
1987: A Robin Poole; J Witter; N Roberts; P J Roughley; C Webber; I Campbell
Immunodetection and characterization of the degradation of cartilage proteoglycans in vitro and in vivo.
The Journal of rheumatology 1987;14 Spec No():80-2.
1987: J Witter; P J Roughley; C Webber; N Roberts; E Keystone; A Robin Poole
The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluids of patients with arthritis.
Arthritis and rheumatism 1987;30(5):519-29.
1986: Tibor T Glant; Katalin Mikecz; P J Roughley; Edit Buzás; A Robin Poole
Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans.
The Biochemical journal 1986;236(1):71-5.
1986: A Robin Poole; C Webber; I Pidoux; H Choi; LC Rosenberg
Localization of a dermatan sulfate proteoglycan (DS-PGII) in cartilage and the presence of an immunologically related species in other tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1986;34(5):619-25.
1986: LC Rosenberg; H U Choi; A Robin Poole; Kristine Lewandowska; Lloyd A Culp
Biological roles of dermatan sulphate proteoglycans.
Ciba Foundation symposium 1986;124():47-68.
1985: LC Rosenberg; H U Choi; L H Tang; T L Johnson; S Pal; C Webber; A Reiner; A Robin Poole
Isolation of dermatan sulfate proteoglycans from mature bovine articular cartilages.
The Journal of biological chemistry 1985;260(10):6304-13.
1984: A Robin Poole; A Reiner; J S Mort; L H Tang; H U Choi; LC Rosenberg; C B Caputo; J H Kimura; V C Hascall
Cartilage link proteins. Biochemical and immunochemical studies of isolation and heterogeneity.
The Journal of biological chemistry 1984;259(23):14849-56.
1984: A Robin Poole; I Pidoux; Agnes Reiner; H Choi; LC Rosenberg
Association of an extracellular protein (chondrocalcin) with the calcification of cartilage in endochondral bone formation.
The Journal of cell biology 1984;98(1):54-65.
1984: A Robin Poole; I Pidoux; Agnes Reiner; H Choi; LC Rosenberg
The association of a newly discovered protein, called chondrocalcin, with cartilage calcification.
Acta biologica Hungarica 1984;35(2-4):143-9.
1983: J D Paquin; M van der Rest; P J Marie; John S Mort; I Pidoux; A Robin Poole; Peter J Roughley
Biochemical and morphologic studies of cartilage from the adult human sacroiliac joint.
Arthritis and rheumatism 1983;26(7):887-95.
1983: H U Choi; L H Tang; T L Johnson; S Pal; LC Rosenberg; A Reiner; A Robin Poole
Isolation and characterization of a 35,000 molecular weight subunit fetal cartilage matrix protein.
The Journal of biological chemistry 1983;258(1):655-61.