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Robin Poole

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
23
Ionescu, Mirela
17
Reiner, Agnes
17
Rosenberg, LC
16
Billinghurst, Clark
15
Webber, C
12
Wu, William
11
Tchetina, Elena
11
Alini, Mauro
10
Mwale, Fackson
9
Roughley, Peter
9
Pidoux, Isabelle
9
Cartman, Annie
8
Antoniou, John
8
Laverty, Sheila
8
Zhang, Yiping

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Publications

TOP 3
Cibere Jolanda; Zhang Hongbin; Garnero Patrick; Poole A Robin; Lobanok Tatiana; Saxne Tore; Kraus Virginia B; Way Amanda; Thorne Anona; Wong Hubert; Singer Joel; Kopec Jacek; Guermazi Ali; Peterfy Charles; Nicolaou Savvakis; Munk Peter L; Esdaile John M
Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study.
Dejica Valeria M; Mort John S; Laverty Sheila; Percival M David; Antoniou John; Zukor David J; Poole A Robin
Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage.
Conrozier T; Poole A R; Ferrand F; Mathieu P; Vincent F; Piperno M; Verret C; Ionescu M; Vignon E
Serum concentrations of type II collagen biomarkers (C2C, C1, 2C and CPII) suggest different pathophysiologies in patients with hip osteoarthritis.

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All Publications

2009: Cibere Jolanda; Zhang Hongbin; Garnero Patrick; Poole A Robin; Lobanok Tatiana; Saxne Tore; Kraus Virginia B; Way Amanda; Thorne Anona; Wong Hubert; Singer Joel; Kopec Jacek; Guermazi Ali; Peterfy Charles; Nicolaou Savvakis; Munk Peter L; Esdaile John M
Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study.
Arthritis and rheumatism 2009;60(5):1372-80.
2008: Dejica Valeria M; Mort John S; Laverty Sheila; Percival M David; Antoniou John; Zukor David J; Poole A Robin
Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage.
The American journal of pathology 2008;173(1):161-9.
2008: Conrozier T; Poole A R; Ferrand F; Mathieu P; Vincent F; Piperno M; Verret C; Ionescu M; Vignon E
Serum concentrations of type II collagen biomarkers (C2C, C1, 2C and CPII) suggest different pathophysiologies in patients with hip osteoarthritis.
Clinical and experimental rheumatology 2008;26(3):430-5.
2008: Kojima Toshihisa; Kojima Masayo; Noda Kazuya; Ishiguro Naoki; Poole A Robin
Influences of menopause, aging, and gender on the cleavage of type II collagen in cartilage in relationship to bone turnover.
Menopause (New York, N.Y.) 2008;15(1):133-7.
2007: Mullan Ronan H; Matthews Clare; Bresnihan Barry; FitzGerald Oliver; King Lindsay; Poole A Robin; Fearon Ursula; Veale Douglas J
Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy.
Arthritis and rheumatism 2007;56(9):2919-28.
2007: Cahue S; Sharma L; Dunlop D; Ionescu M; Song J; Lobanok T; King L; Poole A Robin
The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(7):819-23.
2007: Maksymowych Walter P; Landewé Robert; Conner-Spady Barbara; Dougados Maxime; Mielants Herman; van der Tempel Hille; Poole A Robin; Wang Nandi; van der Heijde Désirée
Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis.
Arthritis and rheumatism 2007;56(6):1846-53.
2007: Tchetina Elena V; Kobayashi Masahiko; Yasuda Tadashi; Meijers Tineke; Pidoux Isabelle; Poole A Robin
Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(4):247-58.
2007: Conrozier T; Ferrand F; Poole A R; Verret C; Mathieu P; Ionescu M; Vincent F; Piperno M; Spiegel A; Vignon E
Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(4):462-7.
2007: Tchetina Elena V; Di Battista John A; Zukor David J; Antoniou John; Poole A Robin
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.
Arthritis research & therapy 2007;9(4):R75.
2006: Fearon Ursula; Mullan Ronan; Markham Trevor; Connolly Mary; Sullivan Shane; Poole A Robin; FitzGerald Oliver; Bresnihan Barry; Veale Douglas J
Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
Arthritis and rheumatism 2006;54(10):3152-62.
2006: Yasuda Tadashi; Tchetina Elena; Ohsawa Kunitaka; Roughley Peter J; Wu William; Mousa Aisha; Ionescu Mirela; Pidoux Isabelle; Poole A Robin
Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(7):419-29.
2006: Mazzuca Steven A; Poole A Robin; Brandt Kenneth D; Katz Barry P; Lane Kathleen A; Lobanok Tatiana
Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis.
The Journal of rheumatology 2006;33(6):1147-51.
2006: Valverde-Franco G; Binette J S; Li W; Wang H; Chai S; Laflamme F; Tran-Khanh N; Quenneville E; Meijers T; Poole A R; Mort J S; Buschmann M D; Henderson J E
Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice.
Human molecular genetics 2006;15(11):1783-92.
2006: Poole A Robin
Biologic markers and disc degeneration.
The Journal of bone and joint surgery. American volume 2006;88 Suppl 2():72-5.
2006: Nelson F; Billinghurst R C; Pidoux I; Reiner A; Langworthy M; McDermott M; Malogne T; Sitler D F; Kilambi N R; Lenczner E; Poole A R
Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(2):114-9.
2006: Tchetina Elena V; Antoniou John; Tanzer Michael; Zukor David J; Poole A Robin
Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production.
The American journal of pathology 2006;168(1):131-40.
2006: Aurich Matthias; Mwale Fackson; Reiner Agnes; Mollenhauer Juergen A; Anders Jens O; Fuhrmann Reneé A; Kuettner Klaus E; Poole A Robin; Cole Ada A
Collagen and proteoglycan turnover in focally damaged human ankle cartilage: evidence for a generalized response and active matrix remodeling across the entire joint surface.
Arthritis and rheumatism 2006;54(1):244-52.
2005: Maksymowych Walter P; Poole A Robin; Hiebert Lori; Webb Alison; Ionescu Mirela; Lobanok Tatiana; King Lindsay; Davis John C
Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis.
The Journal of rheumatology 2005;32(10):1911-7.
2005: Cibere Jolanda; Thorne Anona; Kopec Jacek A; Singer Joel; Canvin Janice; Robinson David B; Pope Janet; Hong Paul; Grant Eric; Lobanok Tatiana; Ionescu Mirela; Poole A Robin; Esdaile John M
Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: randomized discontinuation trial results employing biomarkers.
The Journal of rheumatology 2005;32(5):896-902.
2005: Tchetina Elena V; Squires Ginette; Poole A Robin
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
The Journal of rheumatology 2005;32(5):876-86.
2005: Tiraloche Gabrielle; Girard Christiane; Chouinard Luc; Sampalis John; Moquin Luc; Ionescu Mirela; Reiner Agnes; Poole A Robin; Laverty Sheila
Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis.
Arthritis and rheumatism 2005;52(4):1118-28.
2005: Kim Tae-Hwan; Stone Millicent; Payne Ursula; Zhang Xiang; Ionescu Mirela; Lobanok Tatiana; King Lindsay; Poole A Robin; Inman Robert D
Cartilage biomarkers in ankylosing spondylitis: relationship to clinical variables and treatment response.
Arthritis and rheumatism 2005;52(3):885-91.
2005: Beynnon Bruce D; Uh Benjamin S; Johnson Robert J; Abate Joseph A; Nichols Claude E; Fleming Braden C; Poole A Robin; Roos Harald
Rehabilitation after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind comparison of programs administered over 2 different time intervals.
The American journal of sports medicine 2005;33(3):347-59.
2005: Kobayashi Masahiko; Squires Ginette R; Mousa Aisha; Tanzer Michael; Zukor David J; Antoniou John; Feige Ulrich; Poole A Robin
Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.
Arthritis and rheumatism 2005;52(1):128-35.
2005: Aurich Matthias; Squires Ginette R; Reiner Agnes; Mollenhauer Juergen A; Kuettner Klaus E; Poole A Robin; Cole Ada A
Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints.
Arthritis and rheumatism 2005;52(1):112-9.
2005: Holmbeck Kenn; Bianco Paolo; Pidoux Isabelle; Inoue S; Billinghurst R C; Wu W; Chrysovergis Kali; Yamada Susan; Birkedal-Hansen Henning; Poole A Robin
The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone.
Journal of cell science 2005;118(Pt 1):147-56.
2004: Poole A Robin; Ionescu Mirela; Fitzcharles M A; Billinghurst R Clark
The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases.
Journal of immunological methods 2004;294(1-2):145-53.
2004: Shi Shuiliang; Grothe Suzanne; Zhang Yiping; O'Connor-McCourt Maureen D; Poole A Robin; Roughley Peter J; Mort John S
Link protein has greater affinity for versican than aggrecan.
The Journal of biological chemistry 2004;279(13):12060-6.
2004: Matyas John R; Atley Lynne; Ionescu Mirela; Eyre David R; Poole A Robin
Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis.
Arthritis and rheumatism 2004;50(2):543-52.
2004: Billinghurst R Clark; Mwale Fackson; Hollander Anthony; Ionescu Mirela; Poole A Robin
Immunoassays for collagens in chondrocyte and cartilage explant cultures.
Methods in molecular medicine 2004;100():251-74.
2003: Clements Kristen M; Price Joanne S; Chambers Mark G; Visco Denise M; Poole A Robin; Mason Roger M
Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
Arthritis and rheumatism 2003;48(12):3452-63.
2003: Fraser Alexander; Fearon Ursula; Billinghurst R Clark; Ionescu Mirela; Reece Richard; Barwick Thomas; Emery Paul; Poole A Robin; Veale Douglas J
Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.
Arthritis and rheumatism 2003;48(11):3085-95.
2003: Poole A Robin
Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis.
Rheumatic diseases clinics of North America 2003;29(4):803-18.
2003: Shi Shuiliang; Ciurli Cristina; Cartman Annie; Pidoux Isabelle; Poole A Robin; Zhang Yiping
Experimental immunity to the G1 domain of the proteoglycan versican induces spondylitis and sacroiliitis, of a kind seen in human spondylarthropathies.
Arthritis and rheumatism 2003;48(10):2903-15.
2003: Yasuda Tadashi; Poole A Robin; Shimizu Makoto; Nakagawa Takefumi; Julovi Sohel M; Tamamura Hirokazu; Fujii Nobutaka; Nakamura Takashi
Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture.
Arthritis and rheumatism 2003;48(5):1271-80.
2003: Squires Ginette R; Okouneff Sharon; Ionescu Mirela; Poole A Robin
The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis.
Arthritis and rheumatism 2003;48(5):1261-70.
2003: Tchetina E; Mwale F; Poole A R
Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(5):844-51.
2003: Mwale Fackson; Demers Caroline N; Petit Alain; Roughley Peter; Poole A Robin; Steffen Thomas; Aebi Max; Antoniou John
A synthetic peptide of link protein stimulates the biosynthesis of collagens II, IX and proteoglycan by cells of the intervertebral disc.
Journal of cellular biochemistry 2003;88(6):1202-13.
2003: Leff Richard L; Elias Ileana; Ionescu Mirela; Reiner Agnes; Poole A Robin
Molecular changes in human osteoarthritic cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase inhibitor.
The Journal of rheumatology 2003;30(3):544-9.
2003: Poole A Robin; Nelson Fred; Dahlberg Leif; Tchetina Elena; Kobayashi Masahiko; Yasuda Tadashi; Laverty Sheila; Squires Ginette; Kojima Toshihisa; Wu William; Billinghurst R Clark
Proteolysis of the collagen fibril in osteoarthritis.
Biochemical Society symposium 2003;(70):115-23.
2003: Poole A Robin
What type of cartilage repair are we attempting to attain?
The Journal of bone and joint surgery. American volume 2003;85-A Suppl 2():40-4.
2002: Zhang Yiping; Shi Shuilang; Ciurli Christina; Poole A Robin
Animal models of ankylosing spondylitis.
Current rheumatology reports 2002;4(6):507-12.
2002: Ishiguro Naoki; Kojima Toshihisa; Poole A Robin
Mechanism of cartilage destruction in osteoarthritis.
Nagoya journal of medical science 2002;65(3-4):73-84.
2002: Laverty S; Okouneff S; Ionescu M; Reiner A; Pidoux I; Webber C; Rossier Y; Billinghurst R C; Poole A R
Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(6):1282-9.
2002: Thibault Marc; Poole A Robin; Buschmann Michael D
Cyclic compression of cartilage/bone explants in vitro leads to physical weakening, mechanical breakdown of collagen and release of matrix fragments.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(6):1265-73.
2002: Aurich Matthias; Poole A Robin; Reiner Agnes; Mollenhauer Christine; Margulis Arkady; Kuettner Klaus E; Cole Ada A
Matrix homeostasis in aging normal human ankle cartilage.
Arthritis and rheumatism 2002;46(11):2903-10.
2002: Poole A R; Kobayashi M; Yasuda T; Laverty S; Mwale F; Kojima T; Sakai T; Wahl C; El-Maadawy S; Webb G; Tchetina E; Wu W
Type II collagen degradation and its regulation in articular cartilage in osteoarthritis.
Annals of the rheumatic diseases 2002;61 Suppl 2():ii78-81.
2002: Poole A Robin
Can serum biomarker assays measure the progression of cartilage degeneration in osteoarthritis?
Arthritis and rheumatism 2002;46(10):2549-52.
2002: Chu Q; Lopez M; Hayashi K; Ionescu M; Billinghurst R C; Johnson K A; Poole A R; Markel M D
Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(8):662-9.
2002: Wu William; Billinghurst R Clark; Pidoux Isabelle; Antoniou John; Zukor David; Tanzer Michael; Poole A Robin
Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13.
Arthritis and rheumatism 2002;46(8):2087-94.
2002: Wu C William; Tchetina Elena V; Mwale Fackson; Hasty Karen; Pidoux Isabelle; Reiner Agnes; Chen Jeffrey; Van Wart Harold E; Poole A Robin
Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(4):639-51.
2002: Luttun Aernout; Lupu Florea; Storkebaum Erik; Hoylaerts Marc F; Moons Lieve; Crawley James; Bono Françoise; Poole A Robin; Tipping Peter; Herbert Jean-Marc; Collen Désiré; Carmeliet Peter
Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):499-505.
2002: Price J S; Chambers M G; Poole A R; Fradin A; Mason R M
Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR/ort model of osteoarthritis and in collagen-induced arthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(3):172-9.
2002: Mwale Fackson; Tchetina Elena; Wu C William; Poole A Robin
The assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens II and IX and proteoglycan.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(2):275-83.
2002: Yasuda Tadashi; Poole A Robin
A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathway.
Arthritis and rheumatism 2002;46(1):138-48.
2001: Ishiguro N; Ito T; Oguchi T; Kojima T; Iwata H; Ionescu M; Poole A R
Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis.
Arthritis and rheumatism 2001;44(11):2503-11.
2001: Stoop R; Buma P; van der Kraan P M; Hollander A P; Billinghurst R C; Meijers T H; Poole A R; van den Berg W B
Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(4):308-15.
2001: Robion F C; Doizé B; Bouré L; Marcoux M; Ionescu M; Reiner A; Poole A R; Laverty S
Use of synovial fluid markers of cartilage synthesis and turnover to study effects of repeated intra-articular administration of methylprednisolone acetate on articular cartilage in vivo.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(2):250-8.
2001: van der Kraan P M; Stoop R; Meijers T H; Poole A R; van den Berg W B
Expression of type X collagen in young and old C57Bl/6 and Balb/c mice. Relation with articular cartilage degeneration.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):92-100.
2001: Kojima T; Mwale F; Yasuda T; Girard C; Poole A R; Laverty S
Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis.
Arthritis and rheumatism 2001;44(1):120-7.
2001: Neuhold L A; Killar L; Zhao W; Sung M L; Warner L; Kulik J; Turner J; Wu W; Billinghurst C; Meijers T; Poole A R; Babij P; DeGennaro L J
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.
The Journal of clinical investigation 2001;107(1):35-44.
2001: Wu W; Mwale F; Tchetina E; Kojima T; Yasuda T; Poole A R
Cartilage matrix resorption in skeletogenesis.
Novartis Foundation symposium 2001;232():158-66; discussion 166-70.
2001: Billinghurst R C; Ionescu M; Poole A R
Immunoassay for collagenase-mediated cleavage of types I and II collagens.
Methods in molecular biology (Clifton, N.J.) 2001;151():457-72.
2000: Mwale F; Billinghurst C; Wu W; Alini M; Webber C; Reiner A; Ionescu M; Poole J; Poole A R
Selective assembly and remodelling of collagens II and IX associated with expression of the chondrocyte hypertrophic phenotype.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;218(4):648-62.
2000: Laverty S; Ionescu M; Marcoux M; Bouré L; Doizé B; Poole A R
Alterations in cartilage type-II procollagen and aggrecan contents in synovial fluid in equine osteochondrosis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(3):399-405.
2000: Li N L; Zhang D Q; Zhou K Y; Cartman A; Leroux J Y; Poole A R; Zhang Y P
Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients.
Cell research 2000;10(1):39-49.
2000: Dahlberg L; Billinghurst R C; Manner P; Nelson F; Webb G; Ionescu M; Reiner A; Tanzer M; Zukor D; Chen J; van Wart H E; Poole A R
Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).
Arthritis and rheumatism 2000;43(3):673-82.
2000: Billinghurst R C; Wu W; Ionescu M; Reiner A; Dahlberg L; Chen J; van Wart H; Poole A R
Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase.
Arthritis and rheumatism 2000;43(3):664-72.
1999: Armstrong L; Thickett D R; Mansell J P; Ionescu M; Hoyle E; Billinghurst R C; Poole A R; Millar A B
Changes in collagen turnover in early acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 1999;160(6):1910-5.
1999: Stoop R; van der Kraan P M; Buma P; Hollander A P; Billinghurst R C; Poole A R; van den Berg W B
Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice.
Arthritis and rheumatism 1999;42(11):2381-9.
1999: Holmbeck K; Bianco P; Caterina J; Yamada S; Kromer M; Kuznetsov S A; Mankani M; Robey P G; Poole A R; Pidoux I; Ward J M; Birkedal-Hansen H
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.
Cell 1999;99(1):81-92.
1999: Song X y; Zeng L; Jin W; Thompson J; Mizel D E; Lei K; Billinghurst R C; Poole A R; Wahl S M
Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis.
The Journal of experimental medicine 1999;190(4):535-42.
1999: Stoop R; van der Kraan P M; Buma P; Hollander A P; Poole A R; van den Berg W B
Denaturation of type II collagen in articular cartilage in experimental murine arthritis. Evidence for collagen degradation in both reversible and irreversible cartilage damage.
The Journal of pathology 1999;188(3):329-37.
1999: Billinghurst R C; O'Brien K; Poole A R; McIlwraith C W
Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.
Annals of the New York Academy of Sciences 1999;878():594-7.
1999: Sztrolovics R; White R J; Poole A R; Mort J S; Roughley P J
Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.
The Biochemical journal 1999;339 ( Pt 3)():571-7.
1999: Frisbie D D; Ray C S; Ionescu M; Poole A R; Chapman P L; McIlwraith C W
Measurement of synovial fluid and serum concentrations of the 846 epitope of chondroitin sulfate and of carboxy propeptides of type II procollagen for diagnosis of osteochondral fragmentation in horses.
American journal of veterinary research 1999;60(3):306-9.
1999: Lohmander L S; Ionescu M; Jugessur H; Poole A R
Changes in joint cartilage aggrecan after knee injury and in osteoarthritis.
Arthritis and rheumatism 1999;42(3):534-44.
1999: Guerassimov A; Zhang Y; Cartman A; Rosenberg L C; Esdaile J; Fitzcharles M A; Poole A R
Immune responses to cartilage link protein and the G1 domain of proteoglycan aggrecan in patients with osteoarthritis.
Arthritis and rheumatism 1999;42(3):527-33.
1999: Ishiguro N; Ito T; Ito H; Iwata H; Jugessur H; Ionescu M; Poole A R
Relationship of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover: analyses of synovial fluid from patients with osteoarthritis.
Arthritis and rheumatism 1999;42(1):129-36.
1999: Dumont J; Ionescu M; Reiner A; Poole A R; Tran-Khanh N; Hoemann C D; McKee M D; Buschmann M D
Mature full-thickness articular cartilage explants attached to bone are physiologically stable over long-term culture in serum-free media.
Connective tissue research 1999;40(4):259-72.
1998: Antoniou J; Pike G B; Steffen T; Baramki H; Poole A R; Aebi M; Alini M
Quantitative magnetic resonance imaging in the assessment of degenerative disc disease.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1998;40(6):900-7.
1998: van der Kraan P M; Vitters E L; Meijers T H; Poole A R; van den Berg W B
Collagen type I antisense and collagen type IIA messenger RNA is expressed in adult murine articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(6):417-26.
1998: Zhang Y; Guerassimov A; Leroux J Y; Cartman A; Webber C; Lalic R; de Miguel E; Rosenberg L C; Poole A R
Induction of arthritis in BALB/c mice by cartilage link protein: involvement of distinct regions recognized by T and B lymphocytes.
The American journal of pathology 1998;153(4):1283-91.
1998: Poole A R
The histopathology of ankylosing spondylitis: are there unifying hypotheses?
The American journal of the medical sciences 1998;316(4):228-33.
1998: Guerassimov A; Zhang Y; Banerjee S; Cartman A; Webber C; Esdaile J; Fitzcharles M A; Poole A R
Autoimmunity to cartilage link protein in patients with rheumatoid arthritis and ankylosing spondylitis.
The Journal of rheumatology 1998;25(8):1480-4.
1998: Guerassimov A; Zhang Y; Banerjee S; Cartman A; Leroux J Y; Rosenberg L C; Esdaile J; Fitzcharles M A; Poole A R
Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate.
Arthritis and rheumatism 1998;41(6):1019-25.
1998: Zhang Y; Guerassimov A; Leroux J Y; Cartman A; Webber C; Lalic R; de Miguel E; Rosenberg L C; Poole A R
Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice. Evidence for t cell involvement and the immunosuppressive influence of keratan sulfate on recognition of t and b cell epitopes.
The Journal of clinical investigation 1998;101(8):1678-86.
1997: Carey D E; Alini M; Ionescu M; Hyams J S; Rowe J C; Rosenberg L C; Poole A R
Serum content of the C-propeptide of the cartilage molecule type II collagen in children.
Clinical and experimental rheumatology 1997;15(3):325-8.
1997: Guerassimov A; Duffy C; Zhang Y; Banerjee S; Leroux J Y; Reimann A; Webber C; Delaunay N; Vipparti V; Ronbeck L; Cartman A; Arsenault L; Rosenberg L C; Poole A R
Immunity to cartilage link protein in patients with juvenile rheumatoid arthritis.
The Journal of rheumatology 1997;24(5):959-64.
1997: Billinghurst R C; Dahlberg L; Ionescu M; Reiner A; Bourne R; Rorabeck C; Mitchell P; Hambor J; Diekmann O; Tschesche H; Chen J; Van Wart H; Poole A R
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.
The Journal of clinical investigation 1997;99(7):1534-45.
1996: Poole A R; Rosenberg L C; Reiner A; Ionescu M; Bogoch E; Roughley P J
Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1996;14(5):681-9.
1996: Antoniou J; Goudsouzian N M; Heathfield T F; Winterbottom N; Steffen T; Poole A R; Aebi M; Alini M
The human lumbar endplate. Evidence of changes in biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration.
Spine 1996;21(10):1153-61.
1996: Alini M; Marriott A; Chen T; Abe S; Poole A R
A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation.
Developmental biology 1996;176(1):124-32.
1996: Leroux J Y; Guerassimov A; Cartman A; Delaunay N; Webber C; Rosenberg L C; Banerjee S; Poole A R
Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo.
The Journal of clinical investigation 1996;97(3):621-32.
1996: Alini M; Kofsky Y; Wu W; Pidoux I; Poole A R
In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(1):105-13.
1996: Hollander A P; Heathfield T F; Liu J J; Pidoux I; Roughley P J; Mort J S; Poole A R
Enhanced denaturation of the alpha (II) chains of type-II collagen in normal adult human intervertebral discs compared with femoral articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1996;14(1):61-6.
1995: Hollander A P; Pidoux I; Reiner A; Rorabeck C; Bourne R; Poole A R
Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.
The Journal of clinical investigation 1995;96(6):2859-69.
1995: Poole A R; Nelson F; Hollander A; Reiner A; Pidoux I; Ionescu M
Collagen II turnover in joint diseases.
Acta orthopaedica Scandinavica. Supplementum 1995;266():88-91.
1995: Månsson B; Carey D; Alini M; Ionescu M; Rosenberg L C; Poole A R; Heinegård D; Saxne T
Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism.
The Journal of clinical investigation 1995;95(3):1071-7.
1994: Alini M; Carey D; Hirata S; Grynpas M D; Pidoux I; Poole A R
Cellular and matrix changes before and at the time of calcification in the growth plate studied in vitro: arrest of type X collagen synthesis and net loss of collagen when calcification is initiated.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(7):1077-87.
1994: Poole A R; Ionescu M; Swan A; Dieppe P A
Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis.
The Journal of clinical investigation 1994;94(1):25-33.
1994: Hollander A P; Heathfield T F; Webber C; Iwata Y; Bourne R; Rorabeck C; Poole A R
Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.
The Journal of clinical investigation 1994;93(4):1722-32.
1993: Mort J S; Dodge G R; Roughley P J; Liu J; Finch S J; DiPasquale G; Poole A R
Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage.
Matrix (Stuttgart, Germany) 1993;13(2):95-102.
1993: Carey D E; Alini M; Matsui Y; Poole A R
Density gradient separation of growth plate chondrocytes.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1993;29A(2):117-9.
1993: Poole A R; Rizkalla G; Ionescu M; Reiner A; Brooks E; Rorabeck C; Bourne R; Bogoch E
Osteoarthritis in the human knee: a dynamic process of cartilage matrix degradation, synthesis and reorganization.
Agents and actions. Supplements 1993;39():3-13.
1992: Rizkalla G; Reiner A; Bogoch E; Poole A R
Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease.
The Journal of clinical investigation 1992;90(6):2268-77.
1992: Banerjee S; Webber C; Poole A R
The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4+ and CD8+ T cells.
Cellular immunology 1992;144(2):347-57.
1992: Rajabi M R; Solomon S; Poole A R
Activation of protein kinase C stimulates collagenase production by cultured cells of the cervix of the pregnant guinea pig.
American journal of obstetrics and gynecology 1992;167(1):194-200.
1992: Alini M; Matsui Y; Dodge G R; Poole A R
The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen.
Calcified tissue international 1992;50(4):327-35.
1992: Leroux J Y; Poole A R; Webber C; Vipparti V; Choi H U; Rosenberg L C; Banerjee S
Characterization of proteoglycan-reactive T cell lines and hybridomas from mice with proteoglycan-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2090-6.
1992: Rajabi M R; Quillen E W; Nuwayhid B S; Brandt R; Poole A R
Circulating hyaluronic acid in nonpregnant, pregnant, and postpartum guinea pigs: elevated levels observed at parturition.
American journal of obstetrics and gynecology 1992;166(1 Pt 1):242-6.
1991: Dodge G R; Pidoux I; Poole A R
The degradation of type II collagen in rheumatoid arthritis: an immunoelectron microscopic study.
Matrix (Stuttgart, Germany) 1991;11(5):330-8.
1991: Rajabi M R; Solomon S; Poole A R
Biochemical evidence of collagenase-mediated collagenolysis as a mechanism of cervical dilatation at parturition in the guinea pig.
Biology of reproduction 1991;45(5):764-72.
1991: Matsui Y; Alini M; Webber C; Poole A R
Characterization of aggregating proteoglycans from the proliferative, maturing, hypertrophic, and calcifying zones of the cartilaginous physis.
The Journal of bone and joint surgery. American volume 1991;73(7):1064-74.
1991: Rajabi M; Solomon S; Poole A R
Hormonal regulation of interstitial collagenase in the uterine cervix of the pregnant guinea pig.
Endocrinology 1991;128(2):863-71.
1991: Rajabi M R; Dodge G R; Solomon S; Poole A R
Immunochemical and immunohistochemical evidence of estrogen-mediated collagenolysis as a mechanism of cervical dilatation in the guinea pig at parturition.
Endocrinology 1991;128(1):371-8.
1990: Dayer E; Mathai L; Glant T T; Mikecz K; Poole A R
Cartilage proteoglycan-induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis.
Arthritis and rheumatism 1990;33(9):1394-405.
1990: Mikecz K; Glant T T; Buzás E; Poole A R
Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice.
Arthritis and rheumatism 1990;33(6):866-76.
1990: Poole A R; Witter J; Roberts N; Piccolo F; Brandt R; Paquin J; Baron M
Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of the blood markers hyaluronic acid, orosomucoid, and keratan sulfate.
Arthritis and rheumatism 1990;33(6):790-9.
1990: Lee E R; Matsui Y; Poole A R
Immunochemical and immunocytochemical studies of the C-propeptide of type II procollagen in chondrocytes of the growth plate.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990;38(5):659-73.
1990: Johnson R G; Poole A R
The early response of articular cartilage to ACL transection in a canine model.
Experimental pathology 1990;38(1):37-52.
1989: Poole A R; Pidoux I
Immunoelectron microscopic studies of type X collagen in endochondral ossification.
The Journal of cell biology 1989;109(5):2547-54.
1989: Poole A R; Matsui Y; Hinek A; Lee E R
Cartilage macromolecules and the calcification of cartilage matrix.
The Anatomical record 1989;224(2):167-79.
1989: Poole A R; Webber C; Reiner A; Roughley P J
Studies of a monoclonal antibody to skeletal keratan sulphate. Importance of antibody valency.
The Biochemical journal 1989;260(3):849-56.
1989: Poole A R
Honor Bridgett Fell, Ph.D., D.Sc. F.R.S., D.B.E., 1900-1986. The scientist and her contributions.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1989;25(5):450-3.
1989: Dodge G R; Poole A R
Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.
The Journal of clinical investigation 1989;83(2):647-61.
1988: Hinek A; Poole A R
The influence of vitamin D metabolites on the calcification of cartilage matrix and the C-propeptide of type II collagen (chondrocalcin).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1988;3(4):421-9.
1988: Mikecz K; Glant T T; Baron M; Poole A R
Isolation of proteoglycan-specific T lymphocytes from patients with ankylosing spondylitis.
Cellular immunology 1988;112(1):55-63.
1988: Poole A R; Pidoux I; Reiner A; Rosenberg L; Hollister D; Murray L; Rimoin D
Kniest dysplasia is characterized by an apparent abnormal processing of the C-propeptide of type II cartilage collagen resulting in imperfect fibril assembly.
The Journal of clinical investigation 1988;81(2):579-89.
1988: Johnson R G; Poole A R
Degenerative changes in dog articular cartilage induced by a unilateral tibial valgus osteotomy.
Experimental pathology 1988;33(3):145-64.
1988: Poole A R; Rosenberg L; Murray L; Rimoin D
Kniest dysplasia: a probable type II collagen defect.
Pathology and immunopathology research 1988;7(1-2):95-8.
1987: Webber C; Glant T T; Roughley P J; Poole A R
The identification and characterization of two populations of aggregating proteoglycans of high buoyant density isolated from post-natal human articular cartilages of different ages.
The Biochemical journal 1987;248(3):735-40.
1987: Poole A R; Witter J; Roberts N; Roughley P J; Webber C; Campbell I
Immunodetection and characterization of the degradation of cartilage proteoglycans in vitro and in vivo.
The Journal of rheumatology 1987;14 Spec No():80-2.
1987: Witter J; Roughley P J; Webber C; Roberts N; Keystone E; Poole A R
The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluids of patients with arthritis.
Arthritis and rheumatism 1987;30(5):519-29.
1986: Poole A R; Webber C; Pidoux I; Choi H; Rosenberg L C
Localization of a dermatan sulfate proteoglycan (DS-PGII) in cartilage and the presence of an immunologically related species in other tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1986;34(5):619-25.
1986: Glant T T; Mikecz K; Roughley P J; Buzás E; Poole A R
Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans.
The Biochemical journal 1986;236(1):71-5.
1986: Rosenberg L C; Choi H U; Poole A R; Lewandowska K; Culp L A
Biological roles of dermatan sulphate proteoglycans.
Ciba Foundation symposium 1986;124():47-68.
1985: Rosenberg L C; Choi H U; Tang L H; Johnson T L; Pal S; Webber C; Reiner A; Poole A R
Isolation of dermatan sulfate proteoglycans from mature bovine articular cartilages.
The Journal of biological chemistry 1985;260(10):6304-13.
1984: Poole A R; Reiner A; Mort J S; Tang L H; Choi H U; Rosenberg L C; Caputo C B; Kimura J H; Hascall V C
Cartilage link proteins. Biochemical and immunochemical studies of isolation and heterogeneity.
The Journal of biological chemistry 1984;259(23):14849-56.
1984: Poole A R; Pidoux I; Reiner A; Choi H; Rosenberg L C
Association of an extracellular protein (chondrocalcin) with the calcification of cartilage in endochondral bone formation.
The Journal of cell biology 1984;98(1):54-65.
1984: Poole A R; Pidoux I; Reiner A; Choi H; Rosenberg L C
The association of a newly discovered protein, called chondrocalcin, with cartilage calcification.
Acta biologica Hungarica 1984;35(2-4):143-9.
1983: Paquin J D; van der Rest M; Marie P J; Mort J S; Pidoux I; Poole A R; Roughley P J
Biochemical and morphologic studies of cartilage from the adult human sacroiliac joint.
Arthritis and rheumatism 1983;26(7):887-95.
1983: Choi H U; Tang L H; Johnson T L; Pal S; Rosenberg L C; Reiner A; Poole A R
Isolation and characterization of a 35,000 molecular weight subunit fetal cartilage matrix protein.
The Journal of biological chemistry 1983;258(1):655-61.

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