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Leslie Poole

Research Profile

Chemicals & Drugs

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

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Salmonella typhimurium

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X Ray Crystallography

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Publications

TOP 3
Ryan Michalek; Eun-Yi Moon; Leslie B Poole; Ashley E Weant; Dae-Yeul Yu; Katie E Crump; Elizabeth M Hiltbold; Daniel G Juneau; Jason M Grayson
Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses.
Barbara S Lang; Bernd Mayer; Gustav Oberdorfer; Leslie B Poole; M Verena Wenzl; Cristina M Furdui; Antonius C F Gorren; Karl Gruber
Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry.
Freddie Salsbury; Leslie B Poole; Jacquelyn S Fetrow
Electrostatics of cysteine residues in proteins: parameterization and validation of a simple model.

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2012: Ryan Michalek; Eun-Yi Moon; Leslie B Poole; Ashley E Weant; Dae-Yeul Yu; Katie E Crump; Elizabeth M Hiltbold; Daniel G Juneau; Jason M Grayson
Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses.
Journal of virology 2012;86(24):13629-41.
2012: Barbara S Lang; Bernd Mayer; Gustav Oberdorfer; Leslie B Poole; M Verena Wenzl; Cristina M Furdui; Antonius C F Gorren; Karl Gruber
Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry.
The Journal of biological chemistry 2012;287(45):38124-34.
2012: Freddie Salsbury; Leslie B Poole; Jacquelyn S Fetrow
Electrostatics of cysteine residues in proteins: parameterization and validation of a simple model.
Proteins 2012;80(11):2583-91.
2012: Michael C Gretes; Leslie B Poole; P Andrew Karplus
Peroxiredoxins in parasites.
Antioxidants & redox signaling 2012;17(4):608-33.
2012: Katie E Crump; Karen M Haas; Daniel G Juneau; Leslie B Poole; Jason M Grayson
The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation.
European journal of immunology 2012;42(8):2152-64.
2012: Freddie Salsbury; Ye Yuan; Michael Knaggs; Leslie B Poole; Jacquelyn S Fetrow
Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers.
The journal of physical chemistry. B 2012;116(23):6832-43.
2012: Jiang Qian; Allen W Tsang; Revati Wani; Chananat Klomsiri; Leslie B Poole; Cristina M Furdui
A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes.
Chemical communications (Cambridge, England) 2012;48(34):4091-3.
2012: P Andrew Karplus; Leslie B Poole
Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.
Molecular cell 2012;45(3):275-8.
2012: Seung-Hyun Cho; Jean-Francois Collet; Rachel J Dutton; Derek Parsonage; Leslie B Poole; Casey Thurston; Jon Beckwith
A new family of membrane electron transporters and its substrates, including a new cell envelope peroxiredoxin, reveal a broadened reductive capacity of the oxidative bacterial cell envelope.
mBio 2012;3(2):.
2011: Stacy A Reeves; Kimberly J Nelson; Derek Parsonage; Leslie B Poole
Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin.
Biochemistry 2011;50(41):8970-81.
2011: Leslie B Poole; Andrea Hall; Kimberly J Nelson
Overview of peroxiredoxins in oxidant defense and redox regulation.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2011;Chapter 7():Unit7.9.
2011: Andrea Hall; Kimberly Nelson; Leslie B Poole; P Andrew Karplus
Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Antioxidants & redox signaling 2011;15(3):795-815.
2011: Revati Wani; Leimiao Yin; Erika Bechtold; S Bruce King; Eunok Paek; Leslie B Poole; Jiang Qian; Allen W Tsang; Cristina M Furdui
Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10550-5.
2011: Chananat Klomsiri; P Andrew Karplus; Leslie B Poole
Cysteine-based redox switches in enzymes.
Antioxidants & redox signaling 2011;14(6):1065-77.
2011: Kimberly J Nelson; Stacy Knutson; Laura Soito; Chananat Klomsiri; Leslie B Poole; Jacquelyn S Fetrow
Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis.
Proteins 2011;79(3):947-64.
2011: Teresa E Clarke; Gera Kisselman; Chananat Klomsiri; Emil F Pai; Leslie B Poole; Vladimir Romanov; Jean Wu-Brown; Yuri N Chirgadze; Nickolay Y Chirgadze
Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family.
BMC structural biology 2011;11():27.
2011: Laura Soito; Chris Williamson; Stacy T Knutson; Jacquelyn S Fetrow; Leslie B Poole; Kimberly J Nelson
PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family.
Nucleic acids research 2011;39(Database issue):D332-7.
2010: Jerry A Saunders; LeAnn C Rogers; Chananat Klomsiri; Leslie B Poole; Larry W Daniel
Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells.
Free radical biology & medicine 2010;49(12):2058-67.
2010: Andrea Hall; Derek Parsonage; Leslie B Poole; P Andrew Karplus
Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization.
Journal of molecular biology 2010;402(1):194-209.
2010: Ye Yuan; Jacquelyn S Fetrow; Michael Knaggs; Leslie B Poole; Freddie Salsbury
Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase.
Journal of biomolecular structure & dynamics 2010;28(1):51-70.
2010: Erika Bechtold; Julie A Reisz; Chananat Klomsiri; Allen W Tsang; Marcus W Wright; Leslie B Poole; Cristina M Furdui; S Bruce King
Water-soluble triarylphosphines as biomarkers for protein S-nitrosation.
ACS chemical biology 2010;5(4):405-14.
2010: Derek Parsonage; Daniel C Desrosiers; Karsten R O Hazlett; Yongcheng Sun; Kimberly J Nelson; David L Cox; Justin D Radolf; Leslie B Poole
Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(14):6240-5.
2010: Derek Parsonage; Stacy A Reeves; P Andrew Karplus; Leslie B Poole
Engineering of fluorescent reporters into redox domains to monitor electron transfers.
Methods in enzymology 2010;474():1-21.
2010: Kimberly J Nelson; Chananat Klomsiri; Simona G Codreanu; Laura Soito; Daniel C Liebler; Leann C Rogers; Larry W Daniel; Leslie B Poole
Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins.
Methods in enzymology 2010;473():95-115.
2010: Chananat Klomsiri; Kimberly J Nelson; Erika Bechtold; Laura Soito; Lynnette C Johnson; W Todd Lowther; Seong-Eon Ryu; S Bruce King; Cristina M Furdui; Leslie B Poole
Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.
Methods in enzymology 2010;473():77-94.
2009: Andrea Hall; Banumathi Sankaran; Leslie B Poole; P Andrew Karplus
Structural changes common to catalysis in the Tpx peroxiredoxin subfamily.
Journal of molecular biology 2009;393(4):867-81.
2009: Andrea Hall; Derek Parsonage; David Horita; P Andrew Karplus; Leslie B Poole; Elisar Barbar
Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds.
Biochemistry 2009;48(25):5984-93.
2009: Andrea Hall; P Andrew Karplus; Leslie B Poole
Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
The FEBS journal 2009;276(9):2469-77.
2008: Kimberly J Nelson; Derek Parsonage; Andrea Hall; P Andrew Karplus; Leslie B Poole
Cysteine pK(a) values for the bacterial peroxiredoxin AhpC.
Biochemistry 2008;47(48):12860-8.
2008: Leslie B Poole
Measurement of protein sulfenic acid content.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2008;Chapter 17():Unit17.2.
2008: Pameeka Smith-Pearson; Mitra Kooshki; Douglas R Spitz; Leslie B Poole; Weiling Zhao; Mike E Robbins
Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).
Free radical biology & medicine 2008;45(8):1178-89.
2008: Derek Parsonage; P Andrew Karplus; Leslie B Poole
Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8209-14.
2008: Kimberly J Nelson; Amanda E Day; Bu-Bing Zeng; S Bruce King; Leslie B Poole
Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Analytical biochemistry 2008;375(2):187-95.
2008: Leslie B Poole; Kimberly J Nelson
Discovering mechanisms of signaling-mediated cysteine oxidation.
Current opinion in chemical biology 2008;12(1):18-24.
2008: Freddie Salsbury; Stacy T Knutson; Leslie B Poole; Jacquelyn S Fetrow
Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid.
Protein science : a publication of the Protein Society 2008;17(2):299-312.
2008: Yuji Yamamoto; Dani Ritz; Anne-Gaëlle Planson; Thomas J Jönsson; Melinda J Faulkner; Dana Boyd; Jonathan R. Beckwith; Leslie B Poole
Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity.
Molecular cell 2008;29(1):36-45.
2008: Susan M Hutson; Leslie B Poole; Steven Coles; Myra E Conway
Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase.
Methods in molecular biology (Clifton, N.J.) 2008;476():139-52.
2007: Ryan Michalek; Kimberly J Nelson; Beth C Holbrook; John S Yi; Daya Stridiron; Larry W Daniel; Jacquelyn S Fetrow; S Bruce King; Leslie B Poole; Jason M Grayson
The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6456-67.
2007: Leslie B Poole; Chananat Klomsiri; Sarah A Knaggs; Cristina M Furdui; Kimberly J Nelson; Michael J Thomas; Jacquelyn S Fetrow; Larry W Daniel; S Bruce King
Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins.
Bioconjugate chemistry 2007;18(6):2004-17.
2007: Thomas J Jönsson; Holly R Ellis; Leslie B Poole
Cysteine reactivity and thiol-disulfide interchange pathways in AhpF and AhpC of the bacterial alkyl hydroperoxide reductase system.
Biochemistry 2007;46(19):5709-21.
2007: Leslie B Poole
The catalytic mechanism of peroxiredoxins.
Sub-cellular biochemistry 2007;44():61-81.
2006: Timothy J Phalen; Kelly Weirather; Paula B Deming; Vikas Anathy; Alan K Howe; Albert van der Vliet; Thomas J Jönsson; Leslie B Poole; Nicholas H Heintz
Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery.
The Journal of cell biology 2006;175(5):779-89.
2005: Leslie B Poole; Bu-Bing Zeng; Sarah A Knaggs; Mamudu Yakubu; S Bruce King
Synthesis of chemical probes to map sulfenic acid modifications on proteins.
Bioconjugate chemistry 2005;16(6):1624-8.
2005: Blaine R Roberts; Zachary A. Wood; Thomas J Jönsson; Leslie B Poole; P Andrew Karplus
Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF.
Protein science : a publication of the Protein Society 2005;14(9):2414-20.
2005: Min-Ho Choi; Dana Sajed; Leslie B Poole; Ken Hirata; Scott Herdman; Bruce E Torian; Sharon L Reed
An unusual surface peroxiredoxin protects invasive Entamoeba histolytica from oxidant attack.
Molecular and biochemical parasitology 2005;143(1):80-9.
2005: Derek Parsonage; Derek S Youngblood; Ganapathy N Sarma; Zachary A. Wood; P Andrew Karplus; Leslie B Poole
Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin.
Biochemistry 2005;44(31):10583-92.
2005: Thomas J Jönsson; Michael Murray; Lynnette C Johnson; Leslie B Poole; W Todd Lowther
Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.
Biochemistry 2005;44(24):8634-42.
2005: Leslie B Poole
Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases.
Archives of biochemistry and biophysics 2005;433(1):240-54.
2004: Myra E Conway; Leslie B Poole; Susan M Hutson
Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme.
Biochemistry 2004;43(23):7356-64.
2004: Leslie B Poole
Formation and functions of protein sulfenic acids.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2004;Chapter 17():Unit17.1.
2004: Leslie B Poole; P Andrew Karplus; Al Claiborne
Protein sulfenic acids in redox signaling.
Annual review of pharmacology and toxicology 2004;44():325-47.
2003: Zachary A. Wood; Leslie B Poole; P Andrew Karplus
Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.
Science (New York, N.Y.) 2003;300(5619):650-3.
2003: Myra E Conway; Neela H Yennawar; Reidar Wallin; Leslie B Poole; Susan M Hutson
Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines.
Biochimica et biophysica acta 2003;1647(1-2):61-5.
2003: Ewald Schröder; Thomas J Jönsson; Leslie B Poole
The role of erythrocyte peroxiredoxin in detoxifying peroxides and in stimulating potassium efflux via the Gardos channels.
Blood 2003;101(7):2897; author reply 2898.
2003: Laura M S Baker; Leslie B Poole
Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61.
The Journal of biological chemistry 2003;278(11):9203-11.
2003: Ewald Schröder; Thomas J Jönsson; Leslie B Poole
Hydroxyapatite chromatography: altering the phosphate-dependent elution profile of protein as a function of pH.
Analytical biochemistry 2003;313(1):176-8.
2003: Zachary A. Wood; Ewald Schröder; J Robin Harris; Leslie B Poole
Structure, mechanism and regulation of peroxiredoxins.
Trends in biochemical sciences 2003;28(1):32-40.
2002: Myra E Conway; Neela H Yennawar; Reidar Wallin; Leslie B Poole; Susan M Hutson
Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase.
Biochemistry 2002;41(29):9070-8.
2002: Yuji Yamamoto; Leslie B Poole; Roy R Hantgan; Yoshiyuki Kamio
An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro.
Journal of bacteriology 2002;184(11):2931-9.
2002: Zachary A. Wood; Leslie B Poole; Roy R Hantgan; P Andrew Karplus
Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.
Biochemistry 2002;41(17):5493-504.
2002: C Michael Reynolds; Jacques Meyer; Leslie B Poole
An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum.
Biochemistry 2002;41(6):1990-2001.
2002: Leslie B Poole; Holly R Ellis
Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase.
Methods in enzymology 2002;348():122-36.
2001: Daniel Ritz; J Lim; C Michael Reynolds; Leslie B Poole; Jonathan R. Beckwith
Conversion of a peroxiredoxin into a disulfide reductase by a triplet repeat expansion.
Science (New York, N.Y.) 2001;294(5540):158-60.
2001: C Michael Reynolds; Leslie B Poole
Activity of one of two engineered heterodimers of AhpF, the NADH:peroxiredoxin oxidoreductase from Salmonella typhimurium, reveals intrasubunit electron transfer between domains.
Biochemistry 2001;40(13):3912-9.
2001: Zachary A. Wood; Leslie B Poole; P Andrew Karplus
Structure of intact AhpF reveals a mirrored thioredoxin-like active site and implies large domain rotations during catalysis.
Biochemistry 2001;40(13):3900-11.
2001: Laura M S Baker; Ausra Raudonikiene; Paul S Hoffman; Leslie B Poole
Essential thioredoxin-dependent peroxiredoxin system from Helicobacter pylori: genetic and kinetic characterization.
Journal of bacteriology 2001;183(6):1961-73.
2000: Leslie B Poole; C Michael Reynolds; Zachary A. Wood; P Andrew Karplus; Holly R Ellis; M Li Calzi
AhpF and other NADH:peroxiredoxin oxidoreductases, homologues of low Mr thioredoxin reductase.
European journal of biochemistry / FEBS 2000;267(20):6126-33.
2000: C Michael Reynolds; Leslie B Poole
Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity.
Biochemistry 2000;39(30):8859-69.
2000: Y Yamamoto; M Higuchi; Leslie B Poole; Yoshiyuki Kamio
Role of the dpr product in oxygen tolerance in Streptococcus mutans.
Journal of bacteriology 2000;182(13):3740-7.
2000: Leslie B Poole; A Godzik; A Nayeem; Jeffrey D Schmitt
AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.
Biochemistry 2000;39(22):6602-15.
2000: Leslie B Poole; M Higuchi; M Shimada; M L Calzi; Y Kamio
Streptococcus mutans H2O2-forming NADH oxidase is an alkyl hydroperoxide reductase protein.
Free radical biology & medicine 2000;28(1):108-20.
1997: Holly R Ellis; Leslie B Poole
Novel application of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole to identify cysteine sulfenic acid in the AhpC component of alkyl hydroperoxide reductase.
Biochemistry 1997;36(48):15013-8.
1997: M Li Calzi; Leslie B Poole
Requirement for the two AhpF cystine disulfide centers in catalysis of peroxide reduction by alkyl hydroperoxide reductase.
Biochemistry 1997;36(43):13357-64.
1997: Holly R Ellis; Leslie B Poole
Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium.
Biochemistry 1997;36(43):13349-56.
1997: Leslie B Poole; H Z Chae; B M Flores; Sharon L Reed; S G Rhee; Bruce E Torian
Peroxidase activity of a TSA-like antioxidant protein from a pathogenic amoeba.
Free radical biology & medicine 1997;23(6):955-9.
1996: Leslie B Poole
Flavin-dependent alkyl hydroperoxide reductase from Salmonella typhimurium. 2. Cystine disulfides involved in catalysis of peroxide reduction.
Biochemistry 1996;35(1):65-75.
1996: Leslie B Poole; Holly R Ellis
Flavin-dependent alkyl hydroperoxide reductase from Salmonella typhimurium. 1. Purification and enzymatic activities of overexpressed AhpF and AhpC proteins.
Biochemistry 1996;35(1):56-64.
1995: Edward (E.J.) Crane; Derek Parsonage; Leslie B Poole; Al Claiborne
Analysis of the kinetic mechanism of enterococcal NADH peroxidase reveals catalytic roles for NADH complexes with both oxidized and two-electron-reduced enzyme forms.
Biochemistry 1995;34(43):14114-24.
1994: H Z Chae; K Robison; Leslie B Poole; G Church; G Storz; Sue Goo Rhee
Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7017-21.
1990: Holly Miller; Leslie B Poole; Al Claiborne
Heterogeneity among the flavin-containing NADH peroxidases of group D streptococci. Analysis of the enzyme from Streptococcus faecalis ATCC 9790.
The Journal of biological chemistry 1990;265(17):9857-63.
1989: Leslie B Poole; Al Claiborne
The non-flavin redox center of the streptococcal NADH peroxidase. II. Evidence for a stabilized cysteine-sulfenic acid.
The Journal of biological chemistry 1989;264(21):12330-8.
1989: Leslie B Poole; Al Claiborne
The non-flavin redox center of the streptococcal NADH peroxidase. I. Thiol reactivity and redox behavior in the presence of urea.
The Journal of biological chemistry 1989;264(21):12322-9.
1988: Leslie B Poole; Al Claiborne
Evidence for a single active-site cysteinyl residue in the streptococcal NADH peroxidase.
Biochemical and biophysical research communications 1988;153(1):261-6.
1986: Leslie B Poole; Al Claiborne
Interactions of pyridine nucleotides with redox forms of the flavin-containing NADH peroxidase from Streptococcus faecalis.
The Journal of biological chemistry 1986;261(31):14525-33.