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Grzegorz Popowicz

Research Profile

Concepts & Ideas

Procedures

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Phenomena

Physiology

Protein Folding

Living Beings

Staphylococcus aureus

Co-author Network

Publications

TOP 3
Sohee Baek; Ann M Bode; Sanguine Byun; Zigang Dong; Yong-Seok Heo; Tad A Holak; Robert Huber; Sung Keun Jung; Nam Joo Kang; Bo Yeon Kim; Hyong Joo Lee; Marcelino Arciniega; Martin Augustin; Grzegorz M Popowicz; Nu Ry Song; Ki Won Lee
Structural and functional analysis of the natural JNK1 inhibitor quercetagetin.
David Koes; Grzegorz M Popowicz; Wei Wang; Siglinde Wolf; Alexander Dömling; Tad A Holak; Yijun Huang; Kareem Khoury; Michal Bista; Carlos J Camacho
Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists.
Shravan Kumar Mishra; Roland J Nagel; Grzegorz M Popowicz; Marcin Krajewski; Tim Ammon; Manuel Ares; Tad A Holak; Stefan Jentsch
Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing.

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All Publications

2013: Sohee Baek; Ann M Bode; Sanguine Byun; Zigang Dong; Yong-Seok Heo; Tad A Holak; Robert Huber; Sung Keun Jung; Nam Joo Kang; Bo Yeon Kim; Hyong Joo Lee; Marcelino Arciniega; Martin Augustin; Grzegorz M Popowicz; Nu Ry Song; Ki Won Lee
Structural and functional analysis of the natural JNK1 inhibitor quercetagetin.
Journal of molecular biology 2013;425(2):411-23.
2012: David Koes; Grzegorz M Popowicz; Wei Wang; Siglinde Wolf; Alexander Dömling; Tad A Holak; Yijun Huang; Kareem Khoury; Michal Bista; Carlos J Camacho
Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists.
PloS one 2012;7(3):e32839.
2011: Shravan Kumar Mishra; Roland J Nagel; Grzegorz M Popowicz; Marcin Krajewski; Tim Ammon; Manuel Ares; Tad A Holak; Stefan Jentsch
Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing.
Nature 2011;474(7350):173-8.
2011: Grzegorz M Popowicz; Alexander Dömling; Tad A Holak
The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious.
Angewandte Chemie (International ed. in English) 2011;50(12):2680-8.
2010: Anna Czarna; Barbara Beck; Stuti Srivastava; Grzegorz M Popowicz; Siglinde Wolf; Yijun Huang; Michal Bista; Tad A Holak; Alexander Dömling
Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.
Angewandte Chemie (International ed. in English) 2010;49(31):5352-6.
2010: Anna M Ducka; Peteranne Joel; Grzegorz M Popowicz; Kathleen M Trybus; Michael Schleicher; Angelika A Noegel; Robert Huber; Tad A Holak; Tomasz Sitar
Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(26):11757-62.
2010: Grzegorz M Popowicz; Anna Czarna; Siglinde Wolf; Kan Wang; Wei Wang; Alexander Dömling; Tad A Holak
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.
Cell cycle (Georgetown, Tex.) 2010;9(6):1104-11.
2009: Aleksandra Szwagierczak; Uladzimir Antonenka; Grzegorz M Popowicz; Tomasz Sitar; Tad A Holak; Alexander Rakin
Structures of the arm-type binding domains of HPI and HAI7 integrases.
The Journal of biological chemistry 2009;284(46):31664-71.
2009: Justyna Stec-Niemczyk; Katarzyna Pustelny; Magdalena Kisielewska; Michal Bista; Kevin T Boulware; Henning Stennicke; Ida B Thogersen; Patrick S Daugherty; Jan J Enghild; Krzysztof Baczynski; Grzegorz M Popowicz; Adam Dubin; Jan Potempa; Grzegorz Dubin
Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus.
The Biochemical journal 2009;419(3):555-64.
2009: Anna Czarna; Grzegorz M Popowicz; Aleksandra Pecak; Siglinde Wolf; Grzegorz Dubin; Tad A Holak
High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
Cell cycle (Georgetown, Tex.) 2009;8(8):1176-84.
2009: Valentina Zuckerman; Kristiaan Lenos; Grzegorz M Popowicz; Isabelle Silberman; Tamar Grossman; Jean-Christophe Marine; Tad A Holak; Aart G Jochemsen; Ygal Haupt
c-Abl phosphorylates Hdmx and regulates its interaction with p53.
The Journal of biological chemistry 2009;284(6):4031-9.
2008: Ulli Rothweiler; Anna Czarna; Lutz Weber; Grzegorz M Popowicz; Kinga Brongel; Kaja Kowalska; Michael Orth; Olaf Stemmann; Tad A Holak
NMR screening for lead compounds using tryptophan-mutated proteins.
Journal of medicinal chemistry 2008;51(16):5035-42.
2008: Grzegorz M Popowicz; Anna Czarna; Tad A Holak
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
Cell cycle (Georgetown, Tex.) 2008;7(15):2441-3.
2008: Grzegorz Dubin; Justyna Stec-Niemczyk; Magdalena Kisielewska; Katarzyna Pustelny; Grzegorz M Popowicz; Michal Bista; Tomasz Kantyka; Kevin T Boulware; Henning Stennicke; Anna Czarna; Mullika Phopaisarn; Patrick S Daugherty; Ida B Thøgersen; Jan J Enghild; Nancy Thornberry; Adam Dubin; Jan Potempa
Enzymatic activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln.
Journal of molecular biology 2008;379(2):343-56.
2007: Grzegorz M Popowicz; Anna Czarna; Ulli Rothweiler; Aleksandra Szwagierczak; Marcin Krajewski; Lutz Weber; Tad A Holak
Molecular basis for the inhibition of p53 by Mdmx.
Cell cycle (Georgetown, Tex.) 2007;6(19):2386-92.
2007: Mahavir Singh; Grzegorz M Popowicz; Marcin Krajewski; Tad A Holak
Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
Chembiochem : a European journal of chemical biology 2007;8(11):1308-16.
2006: Berlinda Verdoodt; Anne Benzinger; Grzegorz M Popowicz; Tad A Holak; Heiko Hermeking
Characterization of 14-3-3sigma dimerization determinants: requirement of homodimerization for inhibition of cell proliferation.
Cell cycle (Georgetown, Tex.) 2006;5(24):2920-6.
2006: Tomasz Sitar; Grzegorz M Popowicz; Igor Siwanowicz; Robert Huber; Tad A Holak
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13028-33.
2006: Grzegorz M Popowicz; Michael Schleicher; Angelika A Noegel; Tad A Holak
Filamins: promiscuous organizers of the cytoskeleton.
Trends in biochemical sciences 2006;31(7):411-9.
2006: Aleksandra Mikolajka; Xiumin Yan; Grzegorz M Popowicz; Pawel Smialowski; Erich A Nigg; Tad A Holak
Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization.
Journal of molecular biology 2006;359(4):863-75.
2006: Grzegorz M Popowicz; Grzegorz Dubin; Justyna Stec-Niemczyk; Anna Czarny; Adam Dubin; Jan Potempa; Tad A Holak
Functional and structural characterization of Spl proteases from Staphylococcus aureus.
Journal of molecular biology 2006;358(1):270-9.
2005: Joan L Arolas; Grzegorz M Popowicz; Sílvia Bronsoms; Francesc Aviles; Robert Huber; Tad A Holak; Salvador Ventura
Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond.
Journal of molecular biology 2005;352(4):961-75.
2005: Joan L Arolas; Loyola D'Silva; Grzegorz M Popowicz; Francesc Aviles; Tad A Holak; Salvador Ventura
NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor.
Structure (London, England : 1993) 2005;13(8):1193-202.
2005: Joan L Arolas; Grzegorz M Popowicz; Julia Lorenzo; Christian P Sommerhoff; Robert Huber; Francesc Aviles; Tad A Holak
The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode.
Journal of molecular biology 2005;350(3):489-98.
2005: Anne Benzinger; Grzegorz M Popowicz; Joma K Joy; Sudipta Majumdar; Tad A Holak; Heiko Hermeking
The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization.
Cell research 2005;15(4):219-27.
2005: Igor Siwanowicz; Grzegorz M Popowicz; Magdalena Wisniewska; Robert Huber; Klaus-Peter Künkele; Kurt Lang; Richard A Engh; Tad A Holak
Structural basis for the regulation of insulin-like growth factors by IGF binding proteins.
Structure (London, England : 1993) 2005;13(1):155-67.
2004: Grzegorz M Popowicz; Rolf Müller; Angelika A Noegel; Michael Schleicher; Robert Huber; Tad A Holak
Molecular structure of the rod domain of dictyostelium filamin.
Journal of molecular biology 2004;342(5):1637-46.
2004: Chrystelle Mavoungou; Lars Israel; Till Rehm; Dorota Ksiazek; Marcin Krajewski; Grzegorz M Popowicz; Angelika A Noegel; Michael Schleicher; Tad A Holak
NMR structural characterization of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum.
Journal of biomolecular NMR 2004;29(1):73-84.
2004: Grzegorz Dubin; Grzegorz M Popowicz; Marcin Krajewski; Jan Potempa; Adam Dubin; Tad A Holak
1H, 15N and 13C NMR resonance assignments of staphostatin A, a specific Staphylococcus aureus cysteine proteinase inhibitor.
Journal of biomolecular NMR 2004;28(3):295-6.
2003: Grzegorz Dubin; Marcin Krajewski; Grzegorz M Popowicz; Justyna Stec-Niemczyk; Matthias Bochtler; Jan Potempa; Adam Dubin; Tad A Holak
A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus.
Biochemistry 2003;42(46):13449-56.