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David Porteous

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Andrew M McIntosh; David J Porteous; John M Starr; Albert Tenesa; Peter M Visscher; Alan Gow; Jeremy Hall; Sarah E Harris; David Cherry McLachlan Liewald; Michelle Luciano; Janie Corley; Gail Davies; Ian J Deary
Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age.
C R Gale; Andrew M McIntosh; David J Porteous; G D Batty; Ian J Deary; F Rasmussen
Is bipolar disorder more common in highly intelligent people? A cohort study of a million men.
Donald M Lyall; Susana Muñoz Maniega; Lars Penke; David J Porteous; Natalie A Royle; John M Starr; Maria del C Valdés Hernández; Joanna M Wardlaw; Mark E Bastin; Lorna M Lopez; Ian J Deary
ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936.

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2013: Andrew M McIntosh; David J Porteous; John M Starr; Albert Tenesa; Peter M Visscher; Alan Gow; Jeremy Hall; Sarah E Harris; David Cherry McLachlan Liewald; Michelle Luciano; Janie Corley; Gail Davies; Ian J Deary
Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age.
Biological psychiatry 2013;73(10):938-43.
2013: C R Gale; Andrew M McIntosh; David J Porteous; G D Batty; Ian J Deary; F Rasmussen
Is bipolar disorder more common in highly intelligent people? A cohort study of a million men.
Molecular psychiatry 2013;18(2):190-4.
2013: Donald M Lyall; Susana Muñoz Maniega; Lars Penke; David J Porteous; Natalie A Royle; John M Starr; Maria del C Valdés Hernández; Joanna M Wardlaw; Mark E Bastin; Lorna M Lopez; Ian J Deary
ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936.
Behavior genetics 2013;43(1):13-23.
2012: Uta Griesenbach; Mamoru Hasegawa; Tracy E Higgins; Stephen C Hyde; J Alastair Innes; Makoto Inoue; Angela Kerton; Cuixiang Meng; Nikki K Newman; David J Porteous; Amelia Shoemark; Jun You; A Christopher Boyd; Andrea Brum; Mario Chan; Jane C Davies; Raymond Farley; Deborah R Gill; Eric W F W Alton
Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy.
American journal of respiratory and critical care medicine 2012;186(9):846-56.
2012: Dinesh C Soares; Malcolm D Walkinshaw; Martin A Wear; Juan Zou; Juri Rappsilber; Paul N Barlow; Elizabeth A Blackburn; Bettina Böttcher; Nicholas Bradshaw; Janice Bramham; Zhuo A Chen; Russell S Hamilton; Christopher K Kennaway; J Kirsty Millar; David J Porteous
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.
The Journal of biological chemistry 2012;287(39):32381-93.
2012: Jennifer E Eykelenboom; Shaun Mackie; Paraskevi Makedonopoulou; Elise L V Malavasi; Mary P Malloy; Andrew M McIntosh; Elizabeth A Blackburn; Douglas H Blackwood; Nicholas J Bradshaw; Janice Bramham; Gareth J Briggs; Sheila Christie; Walter J Muir; Fumiaki Ogawa; David J Porteous; Dinesh C Soares; Martin A Wear; J Kirsty Millar
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
Human molecular genetics 2012;21(15):3374-86.
2012: Lorna M Lopez; Susana Muñoz Maniega; Lars Penke; David J Porteous; Natalie A Royle; John M Starr; Albert Tenesa; Maria C Valdés Hernández; Joanna M Wardlaw; Mark E Bastin; Andrea Christoforou; Gail Davies; Ian J Deary
A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity.
Neurobiology of aging 2012;33(8):1847.e1-14.
2012: Rosie M Walker; Susan M Anderson; Pelagia Derizioti; Simon E Fisher; Gillian Hamilton; Alison E Hill; Alice C Newman; Jérôme Nicod; Fumiaki Ogawa; David J Porteous; Pippa A Thomson; Helen S Torrance; Sonja C Vernes; Kathryn L Evans
The DISC1 promoter: characterization and regulation by FOXP2.
Human molecular genetics 2012;21(13):2862-72.
2012: Lorna M Lopez; Michelle Luciano; William Ollier; Antony Payton; Neil Pendleton; Andrew Pickles; David J Porteous; John M Starr; Albert Tenesa; LAWRENCE JEFFREY WHALLEY; Helen Fox; Alan J Gow; Paul Haggerty; Sarah E Harris; Michael A Horan; Xiayi Ke; David Cherry McLachlan Liewald; Gail Davies; Ian J Deary
Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts.
European journal of human genetics : EJHG 2012;20(3):341-7.
2012: L Sha; D G Watson; David J Porteous; D H R Blackwood; N J Brandon; Steven J Clapcote; M P Kelly; Judith Machell; L MacIntyre; Walter J Muir; Ben S Pickard
Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.
Molecular psychiatry 2012;17(3):267-79.
2012: Nicholas J Bradshaw; David J Porteous
DISC1-binding proteins in neural development, signalling and schizophrenia.
Neuropharmacology 2012;62(3):1230-41.
2012: Gillian Hamilton; Donald J Macintyre; Andrew D Morris; David J Porteous; Blair H Smith; Ian J Deary; Anna Dominiczak; Kathryn L Evans; Pippa A Thomson
Alzheimer's disease risk factor complement receptor 1 is associated with depression.
Neuroscience letters 2012;510(1):6-9.
2012: Ian J Deary; Helen C Fox; Michael E Goddard; Alan J Gow; Paul Haggarty; Sarah E Harris; David Cherry McLachlan Liewald; Lorna M Lopez; Michelle Luciano; Geraldine McNeill; David J Porteous; Paul Redmond; Suzanne J Rowe; John M Starr; Albert Tenesa; Janie Corley; Gail Davies; LAWRENCE JEFFREY WHALLEY; Jian Yang; Peter M Visscher
Genetic contributions to stability and change in intelligence from childhood to old age.
Nature 2012;482(7384):212-5.
2012: Andrew K MacLeod; Geraldine McNeill; William Ollier; Antony Payton; Neil Pendleton; Andrew Pickles; David J Porteous; Paul Redmond; John M Starr; Albert Tenesa; Pippa A Thomson; Alan J Gow; Sarah E Harris; Michael Horan; Xiayi Ke; David Cherry McLachlan Liewald; Lorna M Lopez; Michelle Luciano; Janie Corley; Gail Davies; Ian J Deary
Genetic copy number variation and general cognitive ability.
PloS one 2012;7(12):e37385.
2011: David J Porteous; Nicholas J Brandon; J Kirsty Millar; Akira Sawa
DISC1 at 10: connecting psychiatric genetics and neuroscience.
Trends in molecular medicine 2011;17(12):699-706.
2011: Varrie Ogilvie; Margaret Passmore; David J Porteous; Pallav Shah; Barbara Stevenson; Abigail Wilson; Heather Davidson; Jane C Davies; Robert D Gray; Laura Hyndman; Lisa Jones; Robert R Kitchen; Eric W Alton; A Christopher Boyd
Differential global gene expression in cystic fibrosis nasal and bronchial epithelium.
Genomics 2011;98(5):327-36.
2011: Gerry McLachlan; Hazel Painter; David J Porteous; Ian Pringle; Ronald K Scheule; D J Shaw; B Stevenson; Stephanie G Sumner-Jones; P Tennant; Christina Vrettou; A Wilson; Heather Davidson; J C Davies; Lee A Davies; Ann Doherty; Deborah R Gill; C Gordon; Uta Griesenbach; E Holder; Stephen C Hyde; L Hyndman; J A Innes; Eric W F W Alton; Alison Baker; Renald Blundell; A Christopher Boyd; Seng Cheng; R L Coles; D D S Collie
Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.
Gene therapy 2011;18(10):996-1005.
2011: Nicholas Bradshaw; Becky C Carlyle; Sheila Christie; Hazel Davidson-Smith; Shaun Mackie; Fumiaki Ogawa; David J Porteous; Dinesh C Soares; Pippa A Thomson; J Kirsty Millar
PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(24):9043-54.
2011: Goultchira Chakirova; Heather C Whalley; Pippa A Thomson; William Hennah; T William J Moorhead; Killian A Welch; Stephen Giles; Jeremy Hall; Eve C Johnstone; Stephen M Lawrie; David J Porteous; Verity J Brown; Andrew M McIntosh
The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia.
Psychiatry research 2011;192(1):20-8.
2011: Michelle Luciano; Narelle K Hansell; Jari Lahti; Gail Davies; Sarah E Medland; Katri Räikkönen; Albert Tenesa; Elisabeth Widen; McGhee Kevin; Aarno Palotie; David Cherry McLachlan Liewald; David J Porteous; John M Starr; Grant W Montgomery; Nicholas G Martin; Johan G Eriksson; Margaret J Wright; Ian J Deary
Whole genome association scan for genetic polymorphisms influencing information processing speed.
Biological psychology 2011;86(3):193-202.
2011: A Christoforou; K A McGhee; S W Morris; Pippa A Thomson; S Anderson; A McLean; Helen S Torrance; S Le Hellard; Ben S Pickard; D StClair; Walter J Muir; D H Blackwood; David J Porteous; Kathryn L Evans
Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p.
Molecular psychiatry 2011;16(3):240-2.
2011: Wanting Chen; Caroline Hayward; Andrew A Hicks; Sara Knott; Peter P Pramstaller; Igor Rudan; Veronique Vitart; Sarah H Wild; James F Wilson; Alan F Wright; David J Porteous
Copy number variation across European populations.
PloS one 2011;6(8):e23087.
2011: Nigel J McLeish; James McMenamin; David J Porteous; Chris Robertson; Peter Simmonds; Brajendra K Singh; Katy Sinka; Mark Bronsvoort; William Carman; Margo E Chase-Topping; Ian Handel; Shona Kerr; Andrew Leigh-Brown; Mark McGilchrist; M E J Woolhouse
Sero-prevalence and incidence of A/H1N1 2009 influenza infection in Scotland in winter 2009-2010.
PloS one 2011;6(6):e20358.
2011: Ruth Boxall; David J Porteous; Pippa A Thomson
DISC1 and Huntington's disease--overlapping pathways of vulnerability to neurological disorder?
PloS one 2011;6(1):e16263.
2010: Rosie M Walker; Andrea Christoforou; Pippa A Thomson; Kevin A McGhee; Alan Maclean; Thomas W Mühleisen; Jana Strohmaier; Vanessa Nieratschker; Markus M Nöthen; Marcella Rietschel; Sven Cichon; Stewart W Morris; Omer Jilani; David Stclair; Douglas H Blackwood; Walter J Muir; David J Porteous; Kathryn L Evans
Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder.
Neuroscience letters 2010;478(1):9-13.
2010: R D Gray; M Imrie; A Christopher Boyd; David J Porteous; J A Innes; Andrew P Greening
Sputum and serum calprotectin are useful biomarkers during CF exacerbation.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2010;9(3):193-8.
2010: Lorna M Houlihan; Gail Davies; Albert Tenesa; Sarah E Harris; Michelle Luciano; Alan J Gow; McGhee Kevin; David Cherry McLachlan Liewald; David J Porteous; John M Starr; Gordon D Lowe; Peter M Visscher; Ian J Deary
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.
American journal of human genetics 2010;86(4):626-31.
2010: Sarah E Harris; William Hennah; Pippa A Thomson; M Luciano; John M Starr; David J Porteous; Ian J Deary
Variation in DISC1 is associated with anxiety, depression and emotional stability in elderly women.
Molecular psychiatry 2010;15(3):232-4.
2010: Shona M Kerr; David Cherry McLachlan Liewald; Archie Campbell; Kerrie Taylor; Sarah H Wild; David Newby; Marc Turner; David J Porteous
Generation Scotland: Donor DNA Databank; A control DNA resource.
BMC medical genetics 2010;11():166.
2010: Emma Holder; Barbara Stevenson; Raymond Farley; Tom Hilliard; Theresa Wodehouse; Lucinda Somerton; Mia Larsen; Jean O'Donoghue; Rebecca L Coles; Ronald K Scheule; Seng Cheng; Deborah R Gill; Stephen C Hyde; Uta Griesenbach; Eric W F W Alton; David J Porteous; A Christopher Boyd
Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity.
The journal of gene medicine 2010;12(1):55-63.
2009: Helen M Knight; Benjamin S Pickard; Alan Maclean; Mary P Malloy; Dinesh C Soares; Allan F McRae; Alison Condie; Angela White; William Hawkins; Kevin McGhee; Margaret van Beck; Donald J MacIntyre; John M Starr; Ian J Deary; Peter M Visscher; David J Porteous; Ronald E Cannon; David St Clair; Walter J Muir; Douglas H R Blackwood
A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression.
American journal of human genetics 2009;85(6):833-46.
2009: Ellen Grünewald; Hazel L Kinnell; David J Porteous; Pippa A Thomson
GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth.
Molecular and cellular neurosciences 2009;42(4):363-71.
2009: Heather Davidson; Abigail Wilson; Robert D Gray; Alex Horsley; Ian A Pringle; Gerry McLachlan; Angus Nairn; Cordelia Stearns; James Gibson; Emma Holder; Lisa Jones; Ann Doherty; Rebecca Coles; Stephanie G Sumner-Jones; Marguerite Wasowicz; Michelle Manvell; Uta Griesenbach; Stephen C Hyde; Deborah R Gill; Jane Davies; D David S Collie; Eric W F W Alton; David J Porteous; A Christopher Boyd
An immunocytochemical assay to detect human CFTR expression following gene transfer.
Molecular and cellular probes 2009;23(6):272-80.
2009: Lorna M Houlihan; Andrea Christoforou; Margaret I Arbuckle; Helen S Torrance; Susan M Anderson; Walter J Muir; David J Porteous; Douglas H Blackwood; Kathryn L Evans
A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B.
Journal of psychiatric research 2009;43(16):1272-7.
2009: William Hennah; P Thomson; A McQuillin; N Bass; A Loukola; A Anjorin; D H R Blackwood; D Curtis; Ian J Deary; Sarah E Harris; E T Isometsä; J Lawrence; J Lönnqvist; Walter Muir; A Palotie; Timo Partonen; T Paunio; E Pylkkö; M Robinson; P Soronen; K Suominen; J Suvisaari; S Thirumalai; D St Clair; H Gurling; L Peltonen; David J Porteous
DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder.
Molecular psychiatry 2009;14(9):865-73.
2009: Ben S Pickard; A Christoforou; P A Thomson; A Fawkes; K L Evans; S W Morris; David J Porteous; D H R Blackwood; Walter J Muir
Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder.
Molecular psychiatry 2009;14(9):874-84.
2009: E Sprooten; G K S Lymer; S Muñoz Maniega; J McKirdy; J D Clayden; Mark E Bastin; David J Porteous; Eve C Johnstone; Stephen M Lawrie; Jeremy Hall; Andrew M McIntosh
The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants.
Molecular psychiatry 2009;14(3):237-8, 233.
2009: A K Macleod; David Cherry McLachlan Liewald; M M McGilchrist; A D Morris; S M Kerr; David J Porteous
Some principles and practices of genetic biobanking studies.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(2):419-25.
2009: Dinesh C Soares; Paul N Barlow; David J Porteous; Rebecca S Devon
An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin.
Journal of molecular modeling 2009;15(2):113-22.
2009: Stéphanie Le Hellard; Bjarte Håvik; Thomas Espeseth; Harald Breilid; Roger Løvlie; Michelle Luciano; Alan J Gow; Sarah E Harris; John M Starr; Karin Wibrand; Astri J Lundervold; David J Porteous; Clive R Bramham; Ian J Deary; Ivar Reinvang; Vidar M Steen
Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.
PloS one 2009;4(10):e7534.
2009: Dinesh C Soares; Paul N Barlow; Helen J Newbery; David J Porteous; Catherine M Abbott
Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.
PloS one 2009;4(7):e6315.
2008: Nicholas Bradshaw; Fumiaki Ogawa; Beatriz Antolin-Fontes; Jennifer E Chubb; Becky C Carlyle; Sheila Christie; Antoine Claessens; David J Porteous; J Kirsty Millar
DISC1, PDE4B, and NDE1 at the centrosome and synapse.
Biochemical and biophysical research communications 2008;377(4):1091-6.
2008: Andrew M McIntosh; T W J Moorhead; Dominic E Job; G K S Lymer; S Muñoz Maniega; James W McKirdy; J E D Sussmann; B J Baig; Mark E Bastin; David J Porteous; Kathryn L Evans; Eve C Johnstone; Stephen M Lawrie; Jeremy Hall
The effects of a neuregulin 1 variant on white matter density and integrity.
Molecular psychiatry 2008;13(11):1054-9.
2008: Ben S Pickard; H M Knight; R S Hamilton; D C Soares; R Walker; J K F Boyd; Judith Machell; A Maclean; McGhee Kevin; A Condie; David J Porteous; D St Clair; I Davis; D H R Blackwood; Walter J Muir
A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14940-5.
2008: Gordon MacGregor; Robert D Gray; Thomas N Hilliard; Margaret Imrie; A Christopher Boyd; Eric W F W Alton; Andrew Bush; Jane C Davies; J Alastair Innes; David J Porteous; Andrew P Greening
Biomarkers for cystic fibrosis lung disease: application of SELDI-TOF mass spectrometry to BAL fluid.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2008;7(5):352-8.
2008: Asier Unciti-Broceta; Emma Holder; Lisa J Jones; Barbara Stevenson; Andrew R Turner; David J Porteous; A Chris Boyd; Mark Bradley
Tripod-like cationic lipids as novel gene carriers.
Journal of medicinal chemistry 2008;51(14):4076-84.
2008: Lee A Davies; Gerry McLachlan; Stephanie G Sumner-Jones; David Ferguson; Alison Baker; Peter Tennant; Catherine Gordon; Christina Vrettou; Eilidh Baker; Jie Zhu; Eric W F W Alton; D D S Collie; David J Porteous; Stephen C Hyde; Deborah R Gill
Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(7):1283-90.
2008: Stephen C Hyde; Ian Pringle; Syahril Abdullah; Anna E Lawton; Lee A Davies; Anusha Varathalingam; Graciela Nunez-Alonso; Anne-Marie Green; Reto P Bazzani; Stephanie G Sumner-Jones; Mario Chan; Hongyu Li; Nelson S Yew; Seng Cheng; A Christopher Boyd; Jane C Davies; Uta Griesenbach; David J Porteous; David N Sheppard; Felix M Munkonge; Eric W F W Alton; Deborah R Gill
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
Nature biotechnology 2008;26(5):549-51.
2008: A R Horsley; P M Gustafsson; K A Macleod; C Saunders; Andrew P Greening; David J Porteous; J C Davies; S Cunningham; Eric W F W Alton; J Alastair Innes
Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis.
Thorax 2008;63(2):135-40.
2007: Andrea Christoforou; Stéphanie Le Hellard; Pippa A Thomson; stewart morris; A Tenesa; Ben S Pickard; Naomi R Wray; Walter J Muir; D H R Blackwood; David J Porteous; Kathryn L Evans
Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia.
Molecular psychiatry 2007;12(11):1011-25.
2007: J Kirsty Millar; Shaun Mackie; Steven J Clapcote; Hannah Murdoch; Ben S Pickard; Sheila Christie; Walter J Muir; D H R Blackwood; John C Roder; Miles D Houslay; David J Porteous
Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.
The Journal of physiology 2007;584(Pt 2):401-5.
2007: Toby S Scott-Ward; Zhiwei Cai; Elizabeth Dawson; Ann Doherty; Ana Carina Da Paula; Heather Davidson; David J Porteous; Brandon J Wainwright; Margarida D Amaral; David N Sheppard; A Christopher Boyd
Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16365-70.
2007: Koko Ishizuka; J Chen; S Taya; W Li; J Kirsty Millar; Y Xu; Steven J Clapcote; C Hookway; M Morita; Atsushi Kamiya; T Tomoda; B K Lipska; John C Roder; Mikhail V Pletnikov; David J Porteous; A J Silva; T D Cannon; K Kaibuchi; Nicholas J Brandon; Daniel R Weinberger; Akira Sawa
Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice.
Molecular psychiatry 2007;12(10):897-9.
2007: Stefano Ferrari; Uta Griesenbach; A Iida; Raymond Farley; A M Wright; Jie Zhu; Felix M Munkonge; Stephen N Smith; J You; H Ban; M Inoue; M Chan; Charanjit Singh; B Verdon; Barry E Argent; Brandon J Wainwright; Peter K Jeffery; Duncan M Geddes; David J Porteous; Stephen C Hyde; Mike Gray; Mamoru Hasegawa; Eric W F W Alton
Sendai virus-mediated CFTR gene transfer to the airway epithelium.
Gene therapy 2007;14(19):1371-9.
2007: Hannah Murdoch; Shaun Mackie; Daniel M Collins; Elaine V Hill; Graeme B Bolger; Enno Klussmann; David J Porteous; J Kirsty Millar; Miles D Houslay
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(35):9513-24.
2007: Ben S Pickard; Pippa A Thomson; Andrea Christoforou; Kathryn L Evans; stewart morris; David J Porteous; D H R Blackwood; Walter J Muir
The PDE4B gene confers sex-specific protection against schizophrenia.
Psychiatric genetics 2007;17(3):129-33.
2007: Andrew M McIntosh; Ben J Baig; Jeremy Hall; Dominic E Job; Heather C Whalley; G Katherine S Lymer; T William J Moorhead; David G C Owens; Patrick Miller; David J Porteous; Stephen M Lawrie; Eve C Johnstone
Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis.
Biological psychiatry 2007;61(10):1127-34.
2007: Steven J Clapcote; Tatiana Lipina; J Kirsty Millar; Shaun Mackie; Sheila Christie; Fumiaki Ogawa; Jason P Lerch; Keith Trimble; Masashi Uchiyama; Yoshiyuki Sakuraba; Hideki Kaneda; Toshihiko Shiroishi; Miles D Houslay; R Mark Henkelman; John G Sled; Yoichi Gondo; David J Porteous; John C Roder
Behavioral phenotypes of Disc1 missense mutations in mice.
Neuron 2007;54(3):387-402.
2007: Ian Pringle; Gerry McLachlan; D D S Collie; Stephanie G Sumner-Jones; Anna E Lawton; Peter Tennant; Alison Baker; Catherine Gordon; Richard Blundell; Anusha Varathalingam; Lee A Davies; Ralph A Schmid; Seng Cheng; David J Porteous; Deborah R Gill; Stephen C Hyde
Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.
The journal of gene medicine 2007;9(5):369-80.
2007: Stéphanie Le Hellard; Andrew J Lee; Sarah Underwood; Pippa A Thomson; stewart morris; Helen S Torrance; Susan M Anderson; Richard R Adams; Pau Navarro; Andrea Christoforou; Lorna M Houlihan; Sevilla D Detera-Wadleigh; Michael J Owen; Philip Asherson; Walter J Muir; D H R Blackwood; Naomi R Wray; David J Porteous; Kathryn L Evans
Haplotype analysis and a novel allele-sharing method refines a chromosome 4p locus linked to bipolar affective disorder.
Biological psychiatry 2007;61(6):797-805.
2007: Shaun Mackie; J Kirsty Millar; David J Porteous
Role of DISC1 in neural development and schizophrenia.
Current opinion in neurobiology 2007;17(1):95-102.
2007: Gerry McLachlan; Alison Baker; Peter Tennant; Catherine Gordon; Christina Vrettou; Louise Renwick; Richard Blundell; Seng Cheng; Ronald K Scheule; Lee Davies; Hazel Painter; Rebecca L Coles; Anna E Lawton; Chris Marriott; Deborah R Gill; Stephen C Hyde; Uta Griesenbach; Eric W F W Alton; A Christopher Boyd; David J Porteous; D D S Collie
Optimizing aerosol gene delivery and expression in the ovine lung.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(2):348-54.
2007: Ian J Deary; Alan J Gow; Michelle D Taylor; Janie Corley; Caroline Brett; Valerie Wilson; Harry Campbell; LAWRENCE JEFFREY WHALLEY; Peter M Visscher; David J Porteous; John M Starr
The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond.
BMC geriatrics 2007;7():28.
2007: D H R Blackwood; Ben J Pickard; Pippa A Thomson; Kathryn L Evans; David J Porteous; Walter J Muir
Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1.
Neurotoxicity research 2007;11(1):73-83.
2007: Pippa A Thomson; Andrea Christoforou; stewart morris; Euan Adie; Ben S Pickard; David J Porteous; Walter J Muir; D H R Blackwood; Kathryn L Evans
Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population.
Molecular psychiatry 2007;12(1):94-104.
2006: Jeremy Hall; Heather C Whalley; Dominic E Job; Ben J Baig; Andrew M McIntosh; Kathryn L Evans; Pippa A Thomson; David J Porteous; David G Cunningham-Owens; Eve C Johnstone; Stephen M Lawrie
A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms.
Nature neuroscience 2006;9(12):1477-8.
2006: Ben S Pickard; M Pat Malloy; Andrea Christoforou; Pippa A Thomson; Kathryn L Evans; stewart morris; M Hampson; David J Porteous; D H R Blackwood; Walter J Muir
Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder.
Molecular psychiatry 2006;11(9):847-57.
2006: David J Porteous; Pippa Thomson; Nicholas J Brandon; J Kirsty Millar
The genetics and biology of DISC1--an emerging role in psychosis and cognition.
Biological psychiatry 2006;60(2):123-31.
2006: Heather Davidson; Gerry McLachlan; Abigail Wilson; A Christopher Boyd; Ann Doherty; Gordon MacGregor; Lee Davies; Hazel A Painter; Rebecca Coles; Stephen C Hyde; Deborah R Gill; Margarida D Amaral; D D S Collie; David J Porteous; Deborah Penque
Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways.
American journal of respiratory cell and molecular biology 2006;35(1):72-83.
2006: David J Porteous; J Kirsty Millar
Disrupted in schizophrenia 1: building brains and memories.
Trends in molecular medicine 2006;12(6):255-61.
2006: S L Underwood; Andrea Christoforou; Pippa A Thomson; Naomi R Wray; A Tenesa; J Whittaker; R A Adams; Stéphanie Le Hellard; stewart morris; D H R Blackwood; Walter J Muir; David J Porteous; Kathryn L Evans
Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia.
Molecular psychiatry 2006;11(4):384-94.
2006: Euan Adie; Richard R Adams; Kathryn L Evans; David J Porteous; Ben S Pickard
SUSPECTS: enabling fast and effective prioritization of positional candidates.
Bioinformatics (Oxford, England) 2006;22(6):773-4.
2006: Ben S Pickard; Andrew A Pieper; David J Porteous; D H R Blackwood; Walter J Muir
The NPAS3 gene--emerging evidence for a role in psychiatric illness.
Annals of medicine 2006;38(6):439-48.
2005: J Kirsty Millar; Rachel James; Sheila Christie; David J Porteous
Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria.
Molecular and cellular neurosciences 2005;30(4):477-84.
2005: Pippa A Thomson; S E Harris; J M Starr; lawrence whalley; David J Porteous; I J Deary
Association between genotype at an exonic SNP in DISC1 and normal cognitive aging.
Neuroscience letters 2005;389(1):41-5.
2005: J Kirsty Millar; Ben S Pickard; Shaun Mackie; Rachel James; Sheila Christie; Sebastienne R Buchanan; M Pat Malloy; Jennifer E Chubb; Elaine Huston; George S Baillie; Pippa A Thomson; Elaine V Hill; Nicholas J Brandon; Jean-Christophe Rain; L Miguel Camargo; Paul J Whiting; Miles D Houslay; D H R Blackwood; Walter J Muir; David J Porteous
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science (New York, N.Y.) 2005;310(5751):1187-91.
2005: Ben S Pickard; M Pat Malloy; David J Porteous; D H R Blackwood; Walter J Muir
Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):26-32.
2005: Pippa A Thomson; Naomi R Wray; J Kirsty Millar; Kathryn L Evans; S Le Hellard; A Condie; Walter J Muir; D H R Blackwood; David J Porteous
Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.
Molecular psychiatry 2005;10(7):657-68, 616.
2005: Pippa A Thomson; Naomi R Wray; A M Thomson; Donald Dunbar; M A Grassie; A Condie; M T Walker; Daniel J Smith; D J Pulford; Walter Muir; D H R Blackwood; David J Porteous
Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.
Molecular psychiatry 2005;10(5):470-8.
2005: Nicholas J Brandon; Irina Schurov; L Miguel Camargo; EJ Handford; B Duran-Jimeniz; P Hunt; J Kirsty Millar; David J Porteous; Mark S Shearman; Paul J Whiting
Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.
Molecular and cellular neurosciences 2005;28(4):613-24.
2005: Ben S Pickard; M Pat Malloy; Leanne Clark; Stéphanie Lehellard; Henrik Ewald; Ole Mors; David J Porteous; D H R Blackwood; Walter J Muir
Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18.
Psychiatric genetics 2005;15(1):37-44.
2005: Euan Adie; Richard R Adams; Kathryn L Evans; David J Porteous; Ben S Pickard
Speeding disease gene discovery by sequence based candidate prioritization.
BMC bioinformatics 2005;6():55.
2005: Ben S Pickard; J Kirsty Millar; David J Porteous; W J Muir; D H R Blackwood
Cytogenetics and gene discovery in psychiatric disorders.
The pharmacogenomics journal 2005;5(2):81-8.
2004: Stuart Macgregor; Peter M Visscher; Sara A Knott; P Thomson; David J Porteous; J Kirsty Millar; Rebecca S Devon; D H R Blackwood; Walter J Muir
A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42.
Molecular psychiatry 2004;9(12):1083-90.
2004: Xinsheng Nan; Laura Hyndman; Nike Agbi; David J Porteous; A Christopher Boyd
Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA.
Biochemical and biophysical research communications 2004;324(1):348-54.
2004: Laura Hyndman; Jerome L Lemoine; Leaf Huang; David J Porteous; A Christopher Boyd; Xinsheng Nan
HIV-1 Tat protein transduction domain peptide facilitates gene transfer in combination with cationic liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2004;99(3):435-44.
2004: Ben S Pickard; Ed Hollox; M Pat Malloy; David J Porteous; D H R Blackwood; John A L Armour; Walter J Muir
A 4q35.2 subtelomeric deletion identified in a screen of patients with co-morbid psychiatric illness and mental retardation.
BMC medical genetics 2004;5():21.
2004: Rachel James; Richard R Adams; Sheila Christie; S R Buchanan; David J Porteous; J Kirsty Millar
Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria.
Molecular and cellular neurosciences 2004;26(1):112-22.
2004: Stuart Thomas; David J Porteous; Peter M Visscher
Power of direct vs. indirect haplotyping in association studies.
Genetic epidemiology 2004;26(2):116-24.
2003: Euan A Stronach; Grant C Sellar; Cherie Blenkiron; Genevieve J Rabiasz; Karen J Taylor; Eric P Miller; Charles E Massie; Awatif al-Nafussi; John F Smyth; David J Porteous; Hani Gabra
Identification of clinically relevant genes on chromosome 11 in a functional model of ovarian cancer tumor suppression.
Cancer research 2003;63(24):8648-55.
2003: J Kirsty Millar; Sheila Christie; David J Porteous
Yeast two-hybrid screens implicate DISC1 in brain development and function.
Biochemical and biophysical research communications 2003;311(4):1019-25.
2003: Michael Emerson; Louise Renwick; Stephen Tate; Susan Rhind; Elspeth Milne; Hazel Painter; A Christopher Boyd; Gerry McLachlan; Uta Griesenbach; Seng Cheng; Deborah R Gill; Stephen C Hyde; Alison Baker; Eric W F W Alton; David J Porteous; D D S Collie
Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid-DNA complexes to ovine lung segments.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(4):646-53.
2003: D J MacIntyre; D H R Blackwood; David J Porteous; Ben S Pickard; Walter J Muir
Chromosomal abnormalities and mental illness.
Molecular psychiatry 2003;8(3):275-87.
2003: J Kirsty Millar; Pippa A Thomson; Naomi R Wray; Walter J Muir; D H R Blackwood; David J Porteous
Response to Amar J. Klar: The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders.
Genetics 2003;163(2):833-5; author reply 837-8.
2003: David J Porteous; Kathryn L Evans; J Kirsty Millar; Ben S Pickard; Pippa A Thomson; R James; S MacGregor; Naomi R Wray; P M Visscher; Walter J Muir; D H R Blackwood
Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes.
Cold Spring Harbor symposia on quantitative biology 2003;68():383-94.
2003: Martin Taylor; Rebecca S Devon; J Kirsty Millar; David J Porteous
Evolutionary constraints on the Disrupted in Schizophrenia locus.
Genomics 2003;81(1):67-77.
2002: Stuart Macgregor; Peter M Visscher; Sara A Knott; David J Porteous; Walter Muir; Kirsty Millar; D H R Blackwood
Is schizophrenia linked to chromosome 1q?
Science (New York, N.Y.) 2002;298(5602):2277; author reply 2277.
2002: Grant C Sellar; Karen P Watt; Li Li; Barry D Nelkin; Genevieve J Rabiasz; David J Porteous; John F Smyth; Hani Gabra
The homeobox gene BARX2 can modulate cisplatin sensitivity in human epithelial ovarian cancer.
International journal of oncology 2002;21(5):929-33.
2002: Stéphanie Le Hellard; Stéphane J Ballereau; Peter M Visscher; Helen S Torrance; Jeni Pinson; stewart morris; Marian L Thomson; Colin Semple; Walter J Muir; D H R Blackwood; David J Porteous; Kathryn L Evans
SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis.
Nucleic acids research 2002;30(15):e74.
2002: P Thorpe; B J Stevenson; David J Porteous
Optimising gene repair strategies in cell culture.
Gene therapy 2002;9(11):700-2.
2002: P H Thorpe; B J Stevenson; David J Porteous
Functional correction of episomal mutations with short DNA fragments and RNA-DNA oligonucleotides.
The journal of gene medicine 2002;4(2):195-204.
2002: Colin Semple; stewart morris; David J Porteous; Kathryn L Evans
Computational comparison of human genomic sequence assemblies for a region of chromosome 4.
Genome research 2002;12(3):424-9.
2002: Paul Dickinson; Stephen N Smith; Sheila Webb; Fiona M Kilanowski; Isla J Campbell; Martin Taylor; David J Porteous; Rob Willemsen; Hugo R de Jonge; Raymond Farley; Eric W F W Alton; Julia R Dorin
The severe G480C cystic fibrosis mutation, when replicated in the mouse, demonstrates mistrafficking, normal survival and organ-specific bioelectrics.
Human molecular genetics 2002;11(3):243-51.
2001: Grant C Sellar; Li Li; Karen P Watt; Barry D Nelkin; Genevieve J Rabiasz; Euan A Stronach; Eric P Miller; David J Porteous; John F Smyth; Hani Gabra
BARX2 induces cadherin 6 expression and is a functional suppressor of ovarian cancer progression.
Cancer research 2001;61(19):6977-81.
2001: Colin Semple; Kathryn L Evans; stewart morris; David J Porteous
Comparing human genome mapping data.
Science (New York, N.Y.) 2001;293(5539):2394-5.
2001: A J W Paige; Karen J Taylor; C Taylor; S G Hillier; S Farrington; Diane Scott; David J Porteous; John F Smyth; Hani Gabra; JE Watson
WWOX: a candidate tumor suppressor gene involved in multiple tumor types.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11417-22.
2001: Peter M Visscher; M H Yazdi; A D Jackson; Martin Schalling; Kerstin Lindblad; Qiu-Ping Yuan; David J Porteous; Walter J Muir; D H R Blackwood
Genetic survival analysis of age-at-onset of bipolar disorder: evidence for anticipation or cohort effect in families.
Psychiatric genetics 2001;11(3):129-37.
2001: A John Simpson; William A H Wallace; ME Marsden; John R W Govan; David J Porteous; Christopher Haslett; Jean-Michel Sallenave
Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1778-86.
2001: D H R Blackwood; A Fordyce; M T Walker; D M St Clair; David J Porteous; Walter J Muir
Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.
American journal of human genetics 2001;69(2):428-33.
2001: A John Simpson; GA Cunningham; David J Porteous; Christopher Haslett; Jean-Michel Sallenave
Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide.
Human gene therapy 2001;12(11):1395-406.
2001: Rebecca S Devon; S Anderson; PW Teague; P Burgess; T M Kipari; Colin Semple; J Kirsty Millar; Walter J Muir; V Murray; Anthony Pelosi; D H R Blackwood; David J Porteous
Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder.
Psychiatric genetics 2001;11(2):71-8.
2001: Stéphanie Le Hellard; Colin Semple; stewart morris; David J Porteous; Kathryn L Evans
Physical mapping: integrating computational and molecular genetic data.
Annals of human genetics 2001;65(Pt 3):221-8.
2001: Rebecca S Devon; S Anderson; PW Teague; Walter J Muir; V Murray; Anthony Pelosi; D H R Blackwood; David J Porteous
The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia.
Molecular psychiatry 2001;6(3):311-4.
2001: Colin Semple; Rebecca S Devon; Stéphanie Le Hellard; David J Porteous
Identification of genes from a schizophrenia-linked translocation breakpoint region.
Genomics 2001;73(1):123-6.
2001: Walter J Muir; M L Thomson; Patrick McKeon; Lesley Mynett-Johnson; Claire Whitton; Kathryn L Evans; David J Porteous; D H R Blackwood
Markers close to the dopamine D5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder.
American journal of medical genetics 2001;105(2):152-8.
2001: J Kirsty Millar; S Christie; S Anderson; D Lawson; Dawn Loh; Rebecca S Devon; B Arveiler; Walter J Muir; D H R Blackwood; David J Porteous
Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia.
Molecular psychiatry 2001;6(2):173-8.
2001: Kathryn L Evans; Stéphanie Le Hellard; stewart morris; D Lawson; Claire Whitton; Colin Semple; Judy A Fantes; Helen S Torrance; M Pat Malloy; John Maule; Sean Humphray; Mark T Ross; David R Bentley; Walter J Muir; D H R Blackwood; David J Porteous
A 6.9-Mb high-resolution BAC/PAC contig of human 4p15.3-p16.1, a candidate region for bipolar affective disorder.
Genomics 2001;71(3):315-23.
2001: Colin Semple; Kathryn L Evans; David J Porteous
Twin peaks: the draft human genome sequence.
Genome biology 2001;2(3):COMMENT2003.
2001: Kathryn L Evans; Walter J Muir; D H R Blackwood; David J Porteous
Nuts and bolts of psychiatric genetics: building on the Human Genome Project.
Trends in genetics : TIG 2001;17(1):35-40.
2000: Colin Semple; stewart morris; David J Porteous; Kathryn L Evans
In silico identification of transcripts and SNPs from a region of 4p linked with bipolar affective disorder.
Bioinformatics (Oxford, England) 2000;16(8):735-8.
2000: Heather Davidson; Martin Taylor; Ann Doherty; A Christopher Boyd; David J Porteous
Genomic sequence analysis of Fugu rubripes CFTR and flanking genes in a 60 kb region conserving synteny with 800 kb of human chromosome 7.
Genome research 2000;10(8):1194-203.
2000: J Kirsty Millar; Sheila Christie; Colin Semple; David J Porteous
Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia.
Genomics 2000;67(1):69-77.
2000: J Kirsty Millar; JC Wilson-Annan; S Anderson; Sheila Christie; Martin Taylor; Colin Semple; Rebecca S Devon; D M St Clair; Walter J Muir; D H R Blackwood; David J Porteous
Disruption of two novel genes by a translocation co-segregating with schizophrenia.
Human molecular genetics 2000;9(9):1415-23.
2000: Rebecca S Devon; Martin Taylor; J Kirsty Millar; David J Porteous
Isolation and characterization of the mouse translin-associated protein X (Trax) gene.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(5):395-8.
2000: Kathryn L Evans; D Lawson; Thomas Meitinger; D H R Blackwood; David J Porteous
Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder.
American journal of medical genetics 2000;96(2):158-60.
2000: A J W Paige; Karen J Taylor; A Stewart; J G Sgouros; Hani Gabra; Grant C Sellar; John F Smyth; David J Porteous; JE Watson
A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D.
Cancer research 2000;60(6):1690-7.
2000: Gerry McLachlan; BJ Stevenson; Donald J Davidson; David J Porteous
Bacterial DNA is implicated in the inflammatory response to delivery of DNA/DOTAP to mouse lungs.
Gene therapy 2000;7(5):384-92.
2000: P Dickinson; WL Kimber; Fiona M Kilanowski; Sheila Webb; BJ Stevenson; David J Porteous; Julia R Dorin
Enhancing the efficiency of introducing precise mutations into the mouse genome by hit and run gene targeting.
Transgenic research 2000;9(1):55-66.
1999: A Christopher Boyd; F Popp; Uwe Michaelis; Heather Davidson; H Davidson-Smith; Ann Doherty; Gerry McLachlan; David J Porteous; S Seeber
Insertion of natural intron 6a-6b into a human cDNA-derived gene therapy vector for cystic fibrosis improves plasmid stability and permits facile RNA/DNA discrimination.
The journal of gene medicine 1999;1(5):312-21.
1999: A Christopher Boyd; Heather Davidson; B Stevenson; Gerry McLachlan; H Davidson-Smith; David J Porteous
pSURF-2, a modified BAC vector for selective YAC cloning and functional analysis.
BioTechniques 1999;27(1):164-70, 172, 175.
1999: P H Thorpe; David J Porteous
Rapid quantitation of gene therapy specific CFTR expression using the amplification refractory mutation system.
BioTechniques 1999;27(1):122-6.
1999: Heather Davidson; Ann Doherty; B Stevenson; A Christopher Boyd; David J Porteous
Elimination of contaminant Escherichia coli chromosomal DNA from preparations of P1 artificial chromosome recombinants facilitates directed subcloning.
Electrophoresis 1999;20(7):1469-75.
1999: JE Watson; Hani Gabra; Karen J Taylor; Genevieve J Rabiasz; H Morrison; Paul Perry; John F Smyth; David J Porteous
Identification and characterization of a homozygous deletion found in ovarian ascites by representational difference analysis.
Genome research 1999;9(3):226-33.
1998: Donald J Davidson; David J Porteous
Genetics and pulmonary medicine. 1. The genetics of cystic fibrosis lung disease.
Thorax 1998;53(5):389-97.
1998: Eric W F W Alton; Duncan M Geddes; Deborah R Gill; Christopher F Higgins; Stephen C Hyde; J A Innes; David J Porteous
Towards gene therapy for cystic fibrosis: a clinical progress report.
Gene therapy 1998;5(3):291-2.
1998: Stephen N Smith; S J Delaney; Julia R Dorin; Raymond Farley; Duncan M Geddes; David J Porteous; Brandon J Wainwright; Eric W F W Alton
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice.
The American journal of physiology 1998;274(2 Pt 1):C492-9.
1998: J Kirsty Millar; J Brown; John Maule; Y Shibasaki; Sheila Christie; D Lawson; S Anderson; JC Wilson-Annan; Rebecca S Devon; D M St Clair; D H R Blackwood; Walter J Muir; David J Porteous
A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes.
Psychiatric genetics 1998;8(3):175-81.
1998: K Crook; B J Stevenson; M Dubouchet; David J Porteous
Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum.
Gene therapy 1998;5(1):137-43.
1997: A Christopher Boyd; David J Porteous
PCR-generated cross-over linkers for site-directed mutagenesis.
BioTechniques 1997;23(5):827-30.
1997: Ling-Pei Ho; J M Samways; David J Porteous; Julia R Dorin; Andrew D Carothers; Andrew P Greening; J Alastair Innes
Correlation between nasal potential difference measurements, genotype and clinical condition in patients with cystic fibrosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(9):2018-22.
1997: Jean-Michel Sallenave; David J Porteous; Christopher Haslett
Gene therapy for lung inflammatory diseases: not so far away?
Thorax 1997;52(8):742-4.
1997: David J Porteous; Julia R Dorin; Gerry McLachlan; H Davidson-Smith; Heather Davidson; BJ Stevenson; Andrew D Carothers; William A H Wallace; S Moralee; C Hoenes; G Kallmeyer; Uwe Michaelis; Kurt Naujoks; Ling-Pei Ho; J M Samways; M Imrie; Andrew P Greening; J Alastair Innes
Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.
Gene therapy 1997;4(3):210-8.
1997: Rebecca S Devon; Kathryn L Evans; John Maule; Sheila Christie; S Anderson; J Brown; Y Shibasaki; David J Porteous; A J Brookes
Novel transcribed sequences neighbouring a translocation breakpoint associated with schizophrenia.
American journal of medical genetics 1997;74(1):82-90.
1997: JC Wilson-Annan; D H R Blackwood; Walter Muir; J Kirsty Millar; David J Porteous
An allelic association study of two polymorphic markers in close proximity to a balanced translocation t(1:11) that co-segregates with mental illness.
Psychiatric genetics 1997;7(4):171-4.
1997: Rebecca S Devon; David J Porteous
Physical mapping of a glutamate receptor gene in relation to a balanced translocation associated with schizophrenia in a large Scottish family.
Psychiatric genetics 1997;7(4):165-9.
1996: Gerry McLachlan; Ling-Pei Ho; H Davidson-Smith; J Samways; Heather Davidson; B J Stevenson; A D Carothers; Eric W F W Alton; Peter G Middleton; Stephen N Smith; G Kallmeyer; Uwe Michaelis; S Seeber; Kurt Naujoks; Andrew P Greening; J Alastair Innes; Julia R Dorin; David J Porteous
Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP.
Gene therapy 1996;3(12):1113-23.
1996: K Crook; Gerry McLachlan; B J Stevenson; David J Porteous
Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation.
Gene therapy 1996;3(9):834-9.
1996: Julia R Dorin; R Farley; S Webb; Stephen N Smith; E Farini; S J Delaney; B J Wainwright; Eric W F W Alton; David J Porteous
A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction.
Gene therapy 1996;3(9):797-801.
1996: K E Morrison; S J Qureshi; S Anderson; J P Borrett; A Theodosiou; NR Rodrigues; D Blake; A Nesbit; Kay E Davies; David J Porteous; Anthony J Brookes
Novel transcribed sequences represented in the complex genomic region 5q13.
Biochimica et biophysica acta 1996;1308(2):97-102.
1996: D H Blackwood; L He; S W Morris; A McLean; C Whitton; M Thomson; M T Walker; K Woodburn; C M Sharp; Alan F Wright; Y Shibasaki; D M St Clair; David J Porteous; Walter J Muir
A locus for bipolar affective disorder on chromosome 4p.
Nature genetics 1996;12(4):427-30.
1996: Hani Gabra; JE Watson; Karen J Taylor; James Mackay; R C F Leonard; Michael Steel; David J Porteous; John F Smyth
Definition and refinement of a region of loss of heterozygosity at 11q23.3-q24.3 in epithelial ovarian cancer associated with poor prognosis.
Cancer research 1996;56(5):950-4.
1996: S J Delaney; Eric W F W Alton; Stephen N Smith; D P Lunn; R Farley; P K Lovelock; S A Thomson; D A Hume; D Lamb; David J Porteous; Julia R Dorin; Brandon J Wainwright
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.
The EMBO journal 1996;15(5):955-63.
1996: L He; Andrew D Carothers; D H Blackwood; Peter Teague; A W Maclean; J Brown; Alan F Wright; Walter J Muir; David J Porteous; D M St Clair
Recombination patterns around the breakpoints of a balanced 1;11 autosomal translocation associated with major mental illness.
Psychiatric genetics 1996;6(4):201-8.
1996: L He; S Morris; A Lennon; D M St Clair; David J Porteous; Alan F Wright; Walter J Muir; D H Blackwood
A genome-wide search for linkage in a large bipolar family: comparison of genotyping accuracy using di- and tetranucleotide repeat microsatellite markers.
Psychiatric genetics 1996;6(3):123-9.
1995: JE Watson; E M Slorach; John Maule; D Lawson; David J Porteous; Anthony J Brookes
Human repeat-mediated integration of selectable markers into somatic cell hybrids.
Genome research 1995;5(5):444-52.
1995: Gerry McLachlan; Donald J Davidson; B J Stevenson; P Dickinson; H Davidson-Smith; Julia R Dorin; David J Porteous
Evaluation in vitro and in vivo of cationic liposome-expression construct complexes for cystic fibrosis gene therapy.
Gene therapy 1995;2(9):614-22.
1995: P Dickinson; Julia R Dorin; David J Porteous
Modelling cystic fibrosis in the mouse.
Molecular medicine today 1995;1(3):140-8.
1995: M J Francis; M A Nesbit; A M Theodosiou; NR Rodrigues; L Campbell; Z Christodoulou; S J Qureshi; David J Porteous; Anthony J Brookes; Kay E Davies
Mapping of retrotransposon sequences in the unstable region surrounding the spinal muscular atrophy locus in 5q13.
Genomics 1995;27(2):366-9.
1995: Rebecca S Devon; David J Porteous; Anthony J Brookes
Splinkerettes--improved vectorettes for greater efficiency in PCR walking.
Nucleic acids research 1995;23(9):1644-5.
1995: Anthony J Brookes; E M Slorach; K L Evans; M L Thomson; C M Gosden; Walter J Muir; David J Porteous
Identifying genes within microdissected genomic DNA: isolation of brain expressed genes from a translocation region associated with inherited mental illness.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(4):257-62.
1995: Donald J Davidson; Julia R Dorin; Gerry McLachlan; V Ranaldi; D Lamb; C Doherty; John R W Govan; David J Porteous
Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens.
Nature genetics 1995;9(4):351-7.
1995: Y Shibasaki; John Maule; Rebecca S Devon; E M Slorach; JR Gosden; David J Porteous; Anthony J Brookes
Catch-linker + PCR labeling: a simple method to generate fluorescence in situ hybridization probes from yeast artificial chromosomes.
PCR methods and applications 1995;4(4):209-11.
1995: Stephen N Smith; D M Steel; Peter G Middleton; F M Munkonge; Duncan M Geddes; Natasha J Caplen; David J Porteous; Julia R Dorin; Eric W F W Alton
Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: comparison with humans.
The American journal of physiology 1995;268(2 Pt 1):C297-307.
1995: J Petit; P Boisseau; K Evans; Sheila Christie; C Gosden; Walter Muir; D St Clair; David J Porteous; Benoît Arveiler
Seeding of YACs over regions 1q41-q42.3 and 11q14.3-q23 with microdissection clones.
European journal of human genetics : EJHG 1995;3(6):351-6.
1995: K L Evans; Veronica van Heyningen; David J Porteous
Placement and refined mapping of established and new markers on human chromosome 11q using a small panel of somatic cell hybrids.
European journal of human genetics : EJHG 1995;3(1):42-8.
1995: E M Slorach; Mihael H Polymeropoulos; K L Evans; Anne Seawright; J M Fletcher; David J Porteous; Anthony J Brookes
Regional localisation of 19 brain expressed sequence tags to human chromosome 11 using PCR amplification of somatic cell hybrid DNAs.
Cytogenetics and cell genetics 1995;70(1-2):71-5.
1994: Anthony J Brookes; E M Slorach; K E Morrison; S J Qureshi; D Blake; K Davies; David J Porteous
Cloning the shared components of complex DNA resources.
Human molecular genetics 1994;3(11):2011-7.
1994: John Maule; David J Porteous; Anthony J Brookes
An improved method for recovering intact pulsed field gel purified DNA, of at least 1.6 megabases.
Nucleic acids research 1994;22(15):3245-6.
1994: Julia R Dorin; B J Stevenson; S Fleming; Eric W F W Alton; P Dickinson; David J Porteous
Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(8):465-72.
1994: David J Porteous
Current status and future prospects for the treatment of lung disease in cystic fibrosis by gene therapy.
Pulmonary pharmacology 1994;7(3):153-7.
1994: S J Qureshi; David J Porteous; Anthony J Brookes
Alu-based vectorettes and splinkerettes. More efficient and comprehensive polymerase chain reaction amplification of human DNA from complex sources.
Genetic analysis, techniques and applications 1994;11(4):95-101.
1993: P Dickinson; W L Kimber; Fiona M Kilanowski; B J Stevenson; David J Porteous; Julia R Dorin
High frequency gene targeting using insertional vectors.
Human molecular genetics 1993;2(8):1299-302.
1993: A J Brookes; B J Stevenson; David J Porteous; Julia R Dorin
A series of vectors that simplify mammalian gene targeting.
Transgenic research 1993;2(4):238-44.
1993: J M Fletcher; K Evans; D Baillie; P Byrd; D Hanratty; S Leach; C Julier; JR Gosden; Walter Muir; David J Porteous
Schizophrenia-associated chromosome 11q21 translocation: identification of flanking markers and development of chromosome 11q fragment hybrids as cloning and mapping resources.
American journal of human genetics 1993;52(3):478-90.
1993: David J Porteous; Julia R Dorin
Gene therapy for cystic fibrosis--where and when?
Human molecular genetics 1993;2(3):211-2.
1992: M Breen; Benoît Arveiler; I Murray; JR Gosden; David J Porteous
YAC mapping by FISH using Alu-PCR-generated probes.
Genomics 1992;13(3):726-30.
1992: Julia R Dorin; E Emslie; D Hanratty; M Farrall; JR Gosden; David J Porteous
Gene targeting for somatic cell manipulation: rapid analysis of reduced chromosome hybrids by Alu-PCR fingerprinting and chromosome painting.
Human molecular genetics 1992;1(1):53-9.
1992: Benoît Arveiler; David J Porteous
Polyacrylamide-agarose composite gels for high resolution of fingerprints.
Trends in genetics : TIG 1992;8(3):82.
1992: Julia R Dorin; P Dickinson; E Emslie; Alan R Clarke; L Dobbie; M L Hooper; Stephanie Halford; B J Wainwright; David J Porteous
Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells.
Transgenic research 1992;1(2):101-5.
1992: Benoît Arveiler; David J Porteous
Distribution of Alu and L1 repeats in human YAC recombinants.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(12):661-8.
1991: Anthony J Brookes; David J Porteous
Coincident sequence cloning.
Nucleic acids research 1991;19(10):2609-13.
1991: JR Gosden; D Hanratty; J Starling; Judy A Fantes; A Mitchell; David J Porteous
Oligonucleotide-primed in situ DNA synthesis (PRINS): a method for chromosome mapping, banding, and investigation of sequence organization.
Cytogenetics and cell genetics 1991;57(2-3):100-4.
1991: David J Porteous; Julia R Dorin
Cystic fibrosis. 3. Cloning the cystic fibrosis gene: implications for diagnosis and treatment.
Thorax 1991;46(1):46-55.
1991: Benoît Arveiler; I Murray; B Stevenson; David J Porteous
Construction of a library enriched for human chromosome 11 and Xp YAC recombinants.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(4):265-6.
1990: David J Porteous; John Maule
Casting multiple aliquots of agarose-embedded cells for PFGE analysis.
Trends in genetics : TIG 1990;6(11):346.
1990: K Pritchard-Jones; S Fleming; D Davidson; Wendy A Bickmore; David J Porteous; C Gosden; J Bard; A Buckler; J Pelletier; D Housman
The candidate Wilms' tumour gene is involved in genitourinary development.
Nature 1990;346(6280):194-7.
1990: David J Porteous; Julia R Dorin; M M Wilkinson; J M Fletcher; E Emslie; Veronica van Heyningen
SV40-mediated tumor selection and chromosome transfer to enrich for cystic fibrosis region.
Somatic cell and molecular genetics 1990;16(1):29-38.
1989: David J Porteous; M M Wilkinson; J M Fletcher; Veronica van Heyningen
Human-mouse hybrids carrying fragments of single human chromosomes selected by tumor growth.
Genomics 1989;5(4):680-4.
1989: Wendy A Bickmore; David J Porteous; Sheila Christie; Anne Seawright; J M Fletcher; John Maule; P Couillin; C Junien; Nicholas D Hastie; Veronica van Heyningen
CpG islands surround a DNA segment located between translocation breakpoints associated with genitourinary dysplasia and aniridia.
Genomics 1989;5(4):685-93.
1989: Wendy A Bickmore; John Maule; Veronica van Heyningen; David J Porteous
Long-range structure of H-ras 1-selected transgenomes.
Somatic cell and molecular genetics 1989;15(3):229-35.
1989: Julia R Dorin; J D Inglis; David J Porteous
Selection for precise chromosomal targeting of a dominant marker by homologous recombination.
Science (New York, N.Y.) 1989;243(4896):1357-60.
1989: P A Boyd; Sheila Christie; Nicholas D Hastie; David J Porteous
Rapid isolation of moderate and highly polymorphic DNA fragments mapping close to WT (Wilms' tumour) and AN2 (aniridia) on chromosome 11.
Human genetics 1989;81(4):349-52.
1989: Nicholas D Hastie; Wendy A Bickmore; K Pritchard-Jones; David J Porteous; Veronica van Heyningen
Wilms tumour: a developmental anomaly.
Princess Takamatsu symposia 1989;20():145-50.
1988: James Mackay; P A Elder; David J Porteous; C M Steel; RA Hawkins; James Going; U Chetty
Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.
British journal of cancer 1988;58(6):710-4.
1988: Nigel K Spurr; A C Gough; JR Gosden; D Rout; David J Porteous; Veronica van Heyningen; A J Docherty
Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11.
Genomics 1988;2(2):119-27.
1988: Wendy A Bickmore; Sheila Christie; Veronica van Heyningen; Nicholas D Hastie; David J Porteous
Hitch-hiking from HRAS1 to the WAGR locus with CMGT markers.
Nucleic acids research 1988;16(1):51-60.
1988: Nicholas D Hastie; David J Porteous; Wendy A Bickmore; John Maule; Veronica van Heyningen
Molecular analysis of the aniridia--Wilms' tumor syndrome.
Current topics in microbiology and immunology 1988;137():41-6.
1988: Anne Seawright; J M Fletcher; Judy A Fantes; H Morrison; David J Porteous; S S Li; Nicholas D Hastie; Veronica van Heyningen
Analysis of WAGR deletions and related translocations with gene-specific DNA probes, using FACS-selected cell hybrids.
Somatic cell and molecular genetics 1988;14(1):21-30.
1987: David J Porteous; Wendy A Bickmore; Sheila Christie; P A Boyd; G Cranston; J M Fletcher; JR Gosden; D Rout; Anne Seawright; K O Simola
HRAS1-selected chromosome transfer generates markers that colocalize aniridia- and genitourinary dysplasia-associated translocation breakpoints and the Wilms tumor gene within band 11p13.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(15):5355-9.
1986: David J Porteous; J E Morten; M E Foster; G Cranston; E Weir-Thompson; A Busuttil; C J Bobstock; C M Steel
HRAS1-selected, chromosome-mediated transformants vary in phenotype in vitro and tumorigenic potential in vivo.
International journal of cancer. Journal international du cancer 1986;38(4):603-12.
1985: Veronica van Heyningen; P A Boyd; Anne Seawright; J M Fletcher; Judy A Fantes; K E Buckton; G Spowart; David J Porteous; R E Hill; M S Newton
Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8592-6.