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Bernard Portha

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Costes Safia; Vandewalle Brigitte; Tourrel-Cuzin Cécile; Broca Christophe; Linck Nathalie; Bertrand Gyslaine; Kerr-Conte Julie; Portha Bernard; Pattou François; Bockaert Joel; Dalle Stéphane
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.
Lacraz Grégory; Giroix Marie-Hélène; Kassis Nadim; Coulaud Josiane; Galinier Anne; Noll Christophe; Cornut Mélanie; Schmidlin Fabien; Paul Jean-Louis; Janel Nathalie; Irminger Jean-Claude; Kergoat Micheline; Portha Bernard; Donath Marc Y; Ehses Jan A; Homo-Delarche Françoise
Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.
Lacraz Grégory; Figeac Florence; Movassat Jamileh; Kassis Nadim; Coulaud Josiane; Galinier Anne; Leloup Corinne; Bailbé Danielle; Homo-Delarche Françoise; Portha Bernard
Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses.

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2009: Costes Safia; Vandewalle Brigitte; Tourrel-Cuzin Cécile; Broca Christophe; Linck Nathalie; Bertrand Gyslaine; Kerr-Conte Julie; Portha Bernard; Pattou François; Bockaert Joel; Dalle Stéphane
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.
Diabetes 2009;58(5):1105-15.
2009: Lacraz Grégory; Giroix Marie-Hélène; Kassis Nadim; Coulaud Josiane; Galinier Anne; Noll Christophe; Cornut Mélanie; Schmidlin Fabien; Paul Jean-Louis; Janel Nathalie; Irminger Jean-Claude; Kergoat Micheline; Portha Bernard; Donath Marc Y; Ehses Jan A; Homo-Delarche Françoise
Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.
PloS one 2009;4(9):e6963.
2009: Lacraz Grégory; Figeac Florence; Movassat Jamileh; Kassis Nadim; Coulaud Josiane; Galinier Anne; Leloup Corinne; Bailbé Danielle; Homo-Delarche Françoise; Portha Bernard
Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses.
PloS one 2009;4(8):e6500.
2009: Uzan Benjamin; Figeac Florence; Portha Bernard; Movassat Jamileh
Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.
PloS one 2009;4(3):e4734.
2008: Movassat Jamileh; Bailbé Danièle; Lubrano-Berthelier Cécile; Picarel-Blanchot Françoise; Bertin Eric; Mourot Jacques; Portha Bernard
Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion.
American journal of physiology. Endocrinology and metabolism 2008;294(1):E168-75.
2007: Movassat Jamileh; Portha Bernard
Early administration of keratinocyte growth factor improves {beta}-cell regeneration in rat with streptozotocin-induced diabetes.
The Journal of endocrinology 2007;195(2):333-40.
2007: Movassat J; Calderari S; Fernández E; Martín M A; Escrivá F; Plachot C; Gangnerau M N; Serradas P; Alvarez C; Portha B
Type 2 diabetes - a matter of failing beta-cell neogenesis? Clues from the GK rat model.
Diabetes, obesity & metabolism 2007;9 Suppl 2():187-95.
2007: Calderari S; Gangnerau M-N; Thibault M; Meile M-J; Kassis N; Alvarez C; Portha B; Serradas P
Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes.
Diabetologia 2007;50(7):1463-71.
2006: Calderari Sophie; Gangnerau Marie-Noëlle; Meile Marie-José; Portha Bernard; Serradas Patricia
Is defective pancreatic beta-cell mass environmentally programmed in Goto-Kakizaki rat model of type 2 diabetes?: insights from crossbreeding studies during suckling period.
Pancreas 2006;33(4):412-7.
2006: Fernández E; Martín M A; Fajardo S; Bailbé D; Gangnerau M N; Portha B; Escrivá F; Serradas P; Alvarez C
Undernutrition does not alter the activation of beta-cell neogenesis and replication in adult rats after partial pancreatectomy.
American journal of physiology. Endocrinology and metabolism 2006;291(5):E913-21.
2006: Homo-Delarche Françoise; Calderari Sophie; Irminger Jean-Claude; Gangnerau Marie-Noëlle; Coulaud Josiane; Rickenbach Katharina; Dolz Manuel; Halban Philippe; Portha Bernard; Serradas Patricia
Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat.
Diabetes 2006;55(6):1625-33.
2005: Dolz Manuel; Bailbé Danielle; Giroix Marie-Hélène; Calderari Sophie; Gangnerau Marie-Noelle; Serradas Patricia; Rickenbach Katharina; Irminger Jean-Claude; Portha Bernard
Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production.
Diabetes 2005;54(11):3229-37.
2005: Portha Bernard
Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm.
Diabetes/metabolism research and reviews 2005;21(6):495-504.
2005: Martín M A; Serradas P; Ramos S; Fernández E; Goya L; Gangnerau M N; Lacorne M; Pascual-Leone A M; Escrivá F; Portha Bernard; Alvarez C
Protein-caloric food restriction affects insulin-like growth factor system in fetal Wistar rat.
Endocrinology 2005;146(3):1364-71.
2005: Iltis Isabelle; Kober Frank; Desrois Martine; Dalmasso Christiane; Lan Carole; Portha Bernard; Cozzone Patrick J; Bernard Monique
Defective myocardial blood flow and altered function of the left ventricle in type 2 diabetic rats: a noninvasive in vivo study using perfusion and cine magnetic resonance imaging.
Investigative radiology 2005;40(1):19-26.
2003: Portha Bernard
[Transmitted beta-cell dysfunction as a cause for type 2-diabetes]
Médecine sciences : M/S 2003;19(8-9):847-53.
2003: Movassat J; Beattie G M; Lopez A D; Portha B; Hayek A
Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells.
Diabetologia 2003;46(6):822-9.
2003: Even Patrick C; Bertin Eric; Gangnerau Marie-Noelle; Roseau Suzanne; Tome Daniel; Portha Bernard
Energy restriction with protein restriction increases basal metabolism and meal-induced thermogenesis in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(3):R751-9.
2002: Giroix Marie Hélène; Scruel Olivier; Courtois Philippe; Sener Abdullah; Portha Bernard; Malaisse Willy J
Comparison between D-[3-3H]- and D-[5-3H]glucose and fructose utilization in pancreatic islets from control and hereditarily diabetic rats.
Archives of biochemistry and biophysics 2002;408(1):111-23.
2002: Bertin Eric; Gangnerau Marie-Noëlle; Bellon Georges; Bailbé Danièle; Arbelot De Vacqueur Annick; Portha Bernard
Development of beta-cell mass in fetuses of rats deprived of protein and/or energy in last trimester of pregnancy.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(3):R623-30.
2002: Tourrel Cécile; Bailbe Danielle; Lacorne Matthieu; Meile Marie-Jo; Kergoat Micheline; Portha Bernard
Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.
Diabetes 2002;51(5):1443-52.
2002: Giroix Marie-Helene; Nadi Abdellatif Bakkali; Sener Abdullah; Portha Bernard; Malaisse Wiily J
Metabolism of D-[3-3H]glucose, D-[5-3H]glucose, D-[U-14C]glucose, D-[1-14C]glucose and D-[6-14C]glucose in pancreatic islets in an animal model of type-2 diabetes.
International journal of molecular medicine 2002;9(4):381-4.
2002: Serradas Patricia; Goya Luis; Lacorne Matthieu; Gangnerau Marie-Noëlle; Ramos Sonia; Alvarez Carmen; Pascual-Leone Ana-Maria; Portha Bernard
Fetal insulin-like growth factor-2 production is impaired in the GK rat model of type 2 diabetes.
Diabetes 2002;51(2):392-7.
2001: Plachot C; Movassat J; Portha B
Impaired beta-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetes.
Histochemistry and cell biology 2001;116(2):131-9.
2001: Tourrel C; Bailbé D; Meile M J; Kergoat M; Portha B
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.
Diabetes 2001;50(7):1562-70.
2001: Marie J C; Bailbé D; Gylfe E; Portha B
Defective glucose-dependent cytosolic Ca2+ handling in islets of GK and nSTZ rat models of type 2 diabetes.
The Journal of endocrinology 2001;169(1):169-76.
2001: Plachot C; Portha B
Impaired pancreatic duct-cell growth in focal areas of regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of non-insulin dependent diabetes mellitus.
The Histochemical journal 2001;33(3):141-7.
2001: Portha B; Giroix M H; Serradas P; Gangnerau M N; Movassat J; Rajas F; Bailbe D; Plachot C; Mithieux G; Marie J C
beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony.
Diabetes 2001;50 Suppl 1():S89-93.
2001: Miralles F; Portha B
Early development of beta-cells is impaired in the GK rat model of type 2 diabetes.
Diabetes 2001;50 Suppl 1():S84-8.
2000: Alvarez C; Bailbe D; Picarel-Blanchot F; Bertin E; Pascual-Leone A M; Portha B
Effect of early dietary restriction on insulin action and secretion in the GK rat, a spontaneous model of NIDDM.
American journal of physiology. Endocrinology and metabolism 2000;278(6):E1097-103.
2000: Briaud I; Rouault C; Bailbé D; Portha B; Reach G; Poitout V
Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(3):103-6.
2000: Briaud I; Rouault C; Bailbé D; Portha B; Reach G; Poitout V
Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(2):53-6.
1999: Giroix M H; Scruel O; Ladriere L; Sener A; Portha B; Malaisse W J
Metabolic and secretory interactions between D-glucose and D-fructose in islets from GK rats.
Endocrinology 1999;140(12):5556-65.
1999: Scruel O; Giroix M H; Sener A; Portha B; Malaisse W J
Metabolic and secretory response to D-fructose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period.
Molecular genetics and metabolism 1999;68(1):86-90.
1999: Movassat J; Portha B
Beta-cell growth in the neonatal Goto-Kakisaki rat and regeneration after treatment with streptozotocin at birth.
Diabetologia 1999;42(9):1098-106.
1999: Giroix M H; Saulnier C; Portha B
Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: enzymatic, metabolic and secretory data.
Diabetologia 1999;42(8):965-77.
1999: Bertin E; Gangnerau M N; Bailbé D; Portha B
Glucose metabolism and beta-cell mass in adult offspring of rats protein and/or energy restricted during the last week of pregnancy.
The American journal of physiology 1999;277(1 Pt 1):E11-7.
1999: Frayon S; Pessah M; Giroix M H; Mercan D; Boissard C; Malaisse W J; Portha B; Garel J M
Galphaolf identification by RT-PCR in purified normal pancreatic B cells and in islets from rat models of non-insulin-dependent diabetes.
Biochemical and biophysical research communications 1999;254(1):269-72.
1999: Portha B; Movassat J; Plachot C; Saulnier C
[Growth and regeneration potential abnormalities of pancreatic beta-cells in GK rats, NIDDM mellitus model]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1999;():25-38.
1998: Dachicourt N; Bailbé D; Gangnerau M N; Serradas P; Ravel D; Portha B
Effect of gliclazide treatment on insulin secretion and beta-cell mass in non-insulin dependent diabetic Goto-Kakisaki rats.
European journal of pharmacology 1998;361(2-3):243-51.
1998: Bertin E; Ruiz J C; Mourot J; Peiniau P; Portha B
Evaluation of dual-energy X-Ray absorptiometry for body-composition assessment in rats.
The Journal of nutrition 1998;128(9):1550-4.
1998: Leon-Quinto T; Magnan C; Portha B
Altered activity of the autonomous nervous system as a determinant of the impaired beta-cell secretory response after protein-energy restriction in the rat.
Endocrinology 1998;139(8):3382-9.
1998: Bernard C; Thibault C; Berthault M F; Magnan C; Saulnier C; Portha B; Pralong W F; Pénicaud L; Ktorza A
Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.
Diabetes 1998;47(7):1058-65.
1998: Serradas P; Gangnerau M N; Giroix M H; Saulnier C; Portha B
Impaired pancreatic beta cell function in the fetal GK rat. Impact of diabetic inheritance.
The Journal of clinical investigation 1998;101(4):899-904.
1997: Dachicourt N; Serradas P; Bailbé D; Kergoat M; Doaré L; Portha B
Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies.
The Journal of endocrinology 1997;155(2):369-76.
1997: Leon-Quinto T; Adnot P; Portha B
Alteration of the counterregulatory hormones in the conscious rat after protein-energy restriction.
Diabetologia 1997;40(9):1028-34.
1997: Movassat J; Saulnier C; Portha B
Insulin administration enhances growth of the beta-cell mass in streptozotocin-treated newborn rats.
Diabetes 1997;46(9):1445-52.
1997: Movassat J; Saulnier C; Serradas P; Portha B
Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat.
Diabetologia 1997;40(8):916-25.
1997: Berthelier C; Kergoat M; Portha B
Lack of deterioration of insulin action with aging in the GK rat: a contrasted adaptation as compared with nondiabetic rats.
Metabolism: clinical and experimental 1997;46(8):890-6.
1997: Giroix M H; Malaisse-Lagae F; Portha B; Sener A; Malaisse W J
Effects of dehydroepiandrosterone in rats injected with streptozotocin during the neonatal period.
Biochemical and molecular medicine 1997;61(1):72-81.
1997: Alvarez C; Martín M A; Goya L; Bertin E; Portha B; Pascual-Leone A M
Contrasted impact of maternal rat food restriction on the fetal endocrine pancreas.
Endocrinology 1997;138(6):2267-73.
1997: Morin L; Giroix M H; Gangnerau M N; Bailbé D; Portha B
Impaired phosphoinositide metabolism in glucose-incompetent islets of neonatally streptozotocin-diabetic rats.
The American journal of physiology 1997;272(5 Pt 1):E737-45.
1997: Martín M A; Alvarez C; Goya L; Portha B; Pascual-Leone A M
Insulin secretion in adult rats that had experienced different underfeeding patterns during their development.
The American journal of physiology 1997;272(4 Pt 1):E634-40.
1997: Tormo M A; Leon-Quinto T; Saulnier C; Bailbe D; Serradas P; Portha B
Insulin secretion and glucose tolerance after islet transplantation in rats with noninsulin-dependent diabetes induced by neonatal streptozotocin.
Cell transplantation 1997;6(1):23-32.
1997: Tormo M A; Bailbé D; Serradas P; Saulnier C; Portha B; Campillo J E
Transplantation of syngenic pancreatic islets into rats with streptozotocin induced non insulin dependent diabetes mellitus.
Advances in experimental medicine and biology 1997;426():441-5.
1996: Morin L; Giroix M H; Portha B
Decreased ATP-induced synthesis and Ca(2+)-stimulated degradation of polyphosphoinositides in pancreatic islets from neonatally streptozotocin-diabetic rats.
Biochemical and biophysical research communications 1996;228(2):573-8.
1996: Picarel-Blanchot F; Berthelier C; Bailbé D; Portha B
Impaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat.
The American journal of physiology 1996;271(4 Pt 1):E755-62.
1996: Dachicourt N; Serradas P; Giroix M H; Gangnerau M N; Portha B
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP.
The American journal of physiology 1996;271(4 Pt 1):E725-32.
1996: Gauguier D; Froguel P; Parent V; Bernard C; Bihoreau M T; Portha B; James M R; Penicaud L; Lathrop M; Ktorza A
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.
Nature genetics 1996;12(1):38-43.
1996: Portha B; Ktorza A
[Glucotoxicity and insulin secretion. An excessively reductionistic formulation]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1996;():121-31.
1995: Picarel-Blanchot F; Alvarez C; Bailbe D; Pascual-Leone A M; Portha B
Changes in insulin action and insulin secretion in the rat after dietary restriction early in life: influence of food restriction versus low-protein food restriction.
Metabolism: clinical and experimental 1995;44(12):1519-26.
1995: Movassat J; Saulnier C; Portha B
Beta-cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin-dependent diabetes mellitus.
Diabète & métabolisme 1995;21(5):365-70.
1995: Serradas P; Giroix M H; Saulnier C; Gangnerau M N; Borg L A; Welsh M; Portha B; Welsh N
Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of noninsulin-dependent diabetes.
Endocrinology 1995;136(12):5623-31.
1995: Giroix M H; Zhang T M; Leclercq-Meyer V; Sener A; Portha B; Malaisse W J
Restricted effect of formycin A and non-glucidic nutrients upon insulin release in islets from rats with hereditary or acquired non-insulin-dependent diabetes.
Acta diabetologica 1995;32(3):198-202.
1995: Portha B; Kergoat M; Blondel O; Bailbe D
Underfeeding of rat mothers during the first two trimesters of gestation does not alter insulin action and insulin secretion in the progeny.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(4):475-82.
1995: Marfaing-Jallat P; Portha B; Pénicaud L
Altered conditioned taste aversion and glucose utilization in related brain nuclei of diabetic GK rats.
Brain research bulletin 1995;37(6):639-43.
1994: Giroix M H; Sener A; Portha B; Malaisse W J
Enzymatic and secretory activities in pancreatic islets of non-insulin-dependent diabetic rats after short-term infusion of succinic acid monomethyl ester.
Biochemical medicine and metabolic biology 1994;53(2):115-21.
1994: Picarel-Blanchot F; Bailbé D; Portha B
d-Fenfluramine improves hepatic insulin action in streptozotocin-diabetic rats.
European journal of pharmacology 1994;264(2):227-32.
1994: Rasschaert J; Giroix M H; Conget I; Mercan D; Leclercq-Meyer V; Sener A; Portha B; Malaisse W J
Pancreatic islet response to dicarboxylic acid esters in rats with type 2 diabetes: enzymatic, metabolic and secretory aspects.
Journal of molecular endocrinology 1994;13(2):209-17.
1994: Atef N; Portha B; Pénicaud L
Changes in islet blood flow in rats with NIDDM.
Diabetologia 1994;37(7):677-80.
1994: Portha B; Giroix M H; Serradas P; Morin L; Saulnier C; Bailbe D
Glucose refractoriness of pancreatic beta-cells in rat models of non-insulin dependent diabetes.
Diabète & métabolisme 1994;20(2):108-15.
1993: Giroix M H; Sener A; Bailbe D; Leclercq-Meyer V; Portha B; Malaisse W J
Metabolic, ionic, and secretory response to D-glucose in islets from rats with acquired or inherited non-insulin-dependent diabetes.
Biochemical medicine and metabolic biology 1993;50(3):301-21.
1993: Portha B; Serradas P; Bailbé D; Blondel O; Picarel F
Effect of benfluorex on insulin secretion and insulin action in streptozotocin-diabetic rats.
Diabetes/metabolism reviews 1993;9 Suppl 1():57S-63S.
1993: Bisbis S; Bailbe D; Tormo M A; Picarel-Blanchot F; Derouet M; Simon J; Portha B
Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver.
The American journal of physiology 1993;265(5 Pt 1):E807-13.
1993: Thibault C; Guettet C; Laury M C; N'Guyen J M; Tormo M A; Bailbé D; Portha B; Pénicaud L; Ktorza A
In vivo and in vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48-h hyperglycaemic period.
Diabetologia 1993;36(7):589-95.
1993: Sener A; Giroix M H; Malaisse-Lagae F; Bailbe D; Leclercq-Meyer V; Portha B; Malaisse W J
Metabolic response to nonglucidic nutrient secretagogues and enzymatic activities in pancreatic islets of adult rats after neonatal streptozotocin administration.
Biochemical medicine and metabolic biology 1993;49(2):182-99.
1993: Giroix M H; Sener A; Portha B; Malaisse W J
Preferential alteration of oxidative relative to total glycolysis in pancreatic islets of two rat models of inherited or acquired type 2 (non-insulin-dependent) diabetes mellitus.
Diabetologia 1993;36(4):305-9.
1993: Serradas P; Blondel O; Bailbe D; Portha B
Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats.
Diabetes 1993;42(4):564-70.
1993: Giroix M H; Vesco L; Portha B
Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes.
Endocrinology 1993;132(2):815-22.
1992: Escrivá F; Rodríguez C; Cacho J; Alvarez C; Portha B; Pascual-Leone A M
Glucose utilization and insulin action in adult rats submitted to prolonged food restriction.
The American journal of physiology 1992;263(1 Pt 1):E1-7.
1992: Thibault C; Laury M C; Bailbe D; Ktorza A; Portha B
Effect of prolonged in vivo glucose infusion on insulin secretion in rats with previous glucose intolerance.
Endocrinology 1992;130(5):2521-7.
1992: Giroix M H; Baetens D; Rasschaert J; Leclercq-Meyer V; Sener A; Portha B; Malaisse W J
Enzymic and metabolic anomalies in islets of diabetic rats: relationship to B cell mass.
Endocrinology 1992;130(5):2634-40.
1992: Giroix M H; Rasschaert J; Sener A; Leclercq-Meyer V; Bailbe D; Portha B; Malaisse W J
Study of hexose transport, glycerol phosphate shuttle and Krebs cycle in islets of adult rats injected with streptozotocin during the neonatal period.
Molecular and cellular endocrinology 1992;83(2-3):95-104.
1991: Malaisse W J; Giroix M H; Zähner D; Marynissen G; Sener A; Portha B
Neonatal streptozotocin injection: a model of glucotoxicity?
Metabolism: clinical and experimental 1991;40(10):1101-5.
1991: Escriva F; Kergoat M; Bailbé D; Pascual-Leone A M; Portha B
Increased insulin action in the rat after protein malnutrition early in life.
Diabetologia 1991;34(8):559-64.
1991: Laury M C; Takao F; Bailbe D; Penicaud L; Portha B; Picon L; Ktorza A
Differential effects of prolonged hyperglycemia on in vivo and in vitro insulin secretion in rats.
Endocrinology 1991;128(5):2526-33.
1991: Portha B; Serradas P; Bailbé D; Suzuki K; Goto Y; Giroix M H
Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes.
Diabetes 1991;40(4):486-91.
1991: Kergoat M; Guerre-Millo M; Lauva M; Portha B
Increased insulin action in rats with mild insulin deficiency induced by neonatal streptozotocin.
The American journal of physiology 1991;260(4 Pt 1):E561-7.
1991: Giroix M H; Rasschaert J; Bailbe D; Leclercq-Meyer V; Sener A; Portha B; Malaisse W J
Impairment of glycerol phosphate shuttle in islets from rats with diabetes induced by neonatal streptozocin.
Diabetes 1991;40(2):227-32.
1991: Serradas P; Bailbé D; Blondel O; Portha B
Abnormal B-cell function in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin: effect of in vivo insulin, phlorizin, or vanadate treatments.
Pancreas 1991;6(1):54-62.
1990: Giroix M H; Sener A; Bailbe D; Portha B; Malaisse W J
Impairment of the mitochondrial oxidative response to D-glucose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period.
Diabetologia 1990;33(11):654-60.
1990: Blondel O; Bailbe D; Portha B
Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment.
Metabolism: clinical and experimental 1990;39(8):787-93.
1990: Blondel O; Simon J; Chevalier B; Portha B
Impaired insulin action but normal insulin receptor activity in diabetic rat liver: effect of vanadate.
The American journal of physiology 1990;258(3 Pt 1):E459-67.
1989: Blondel O; Portha B
Early appearance of in vivo insulin resistance in adult streptozotocin-injected rats.
Diabète & métabolisme 1989;15(6):382-7.
1989: Giroix M H; Serradas P; Portha B
The desensitization of normal B-cells to glucose in vitro is transient and not related to high glucose levels.
Endocrinology 1989;125(4):1999-2007.
1989: Serradas P; Bailbé D; Portha B
Long-term gliclazide treatment improves the in vitro glucose-induced insulin release in rats with type 2 (non-insulin-dependent) diabetes induced by neonatal streptozotocin.
Diabetologia 1989;32(8):577-84.
1989: Blondel O; Bailbé D; Portha B
Relation of insulin deficiency to impaired insulin action in NIDDM adult rats given streptozocin as neonates.
Diabetes 1989;38(5):610-7.
1989: Blondel O; Bailbe D; Portha B
In vivo insulin resistance in streptozotocin-diabetic rats--evidence for reversal following oral vanadate treatment.
Diabetologia 1989;32(3):185-90.
1989: Portha B; Blondel O; Serradas P; McEvoy R; Giroix M H; Kergoat M; Bailbe D
The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin.
Diabète & métabolisme 1989;15(2):61-75.
1989: Serradas P; Giroix M H; Portha B
Evaluation of the pancreatic B-cell function in the rat after prenatal exposure to streptozotocin or N-nitrosomethylurea.
Diabète & métabolisme 1989;15(1):30-7.
1988: Portha B; Giroix M H; Serradas P; Welsh N; Hellerström C; Sener A; Malaisse W J
Insulin production and glucose metabolism in isolated pancreatic islets of rats with NIDDM.
Diabetes 1988;37(9):1226-33.
1988: Kergoat M; Simon J; Portha B
Insulin binding and insulin receptor tyrosine kinase activity are not altered in the liver of rats with non-insulin-dependent diabetes.
Biochemical and biophysical research communications 1988;152(3):1015-22.
1988: Portha B; Giroix M H; Kergoat M; Bailbe D; Blondel O; Serradas P
[Animal models of non-insulin-dependent diabetes induced in the rat by experimental reduction of B cell mass]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1988;():33-46.
1987: Kergoat M; Bailbe D; Portha B
Effect of high sucrose diet on insulin secretion and insulin action. A study in rats with non-insulin-dependent diabetes induced by streptozotocin.
Diabetologia 1987;30(8):666-73.
1987: Kergoat M; Bailbe D; Portha B
Insulin treatment improves glucose-induced insulin release in rats with NIDDM induced by streptozocin.
Diabetes 1987;36(8):971-7.
1987: Kergoat M; Bailbé D; Portha B
Effect of high sucrose diet on insulin secretion and insulin action: a study in the normal rat.
Diabetologia 1987;30(4):252-8.
1986: Kergoat M; Giroix M H; Portha B
Evidence for normal in vitro Ca2+-stimulated insulin release in rats with non-insulin-dependent diabetes.
Diabète & métabolisme 1986;12(2):79-82.
1985: Kergoat M; Portha B; Picon L
Effect of exogenous insulin on glucose kinetics in rats with noninsulin-dependent diabetes.
Metabolism: clinical and experimental 1985;34(4):377-82.
1984: Giroix M H; Portha B; Kergoat M; Picon L
Glucagon secretion in rats with non-insulin-dependent diabetes: an in vivo and in vitro study.
Diabète & métabolisme 1984;10(1):12-7.
1983: Giroix M H; Portha B; Kergoat M; Bailbe D; Picon L
Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes. A study with the perfused pancreas.
Diabetes 1983;32(5):445-51.

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