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Bernard Portha

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Julien Véret; Viswanathan Natarajan; Bernard Portha; Elena Riccitelli; Anastasia Skobeleva; Evgeny Berdyshev; Nicolas Coant; Magali Fradet; Paola Giussani; Irina A Gorshkova; Jonathan Goya; Nadim Kassis; Hervé Le Stunff
Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival.
Anna Castell-Auví; Lídia Cedó; Jamileh Movassat; Victor Pallarès; Montse Pinent; Bernard Portha; Fátima Sánchez-Cabo; Mayte Blay; Anna Ardévol
Procyanidins modulate microRNA expression in pancreatic islets.
Audrey RIBOULET-CHAVEY; L Maulny; Jamileh Movassat; Danielle Bailbé; J P Renard; Bernard Portha
A euglycaemic/non-diabetic perinatal environment does not alleviate early beta cell maldevelopment and type 2 diabetes risk in the GK/Par rat model.

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2013: Julien Véret; Viswanathan Natarajan; Bernard Portha; Elena Riccitelli; Anastasia Skobeleva; Evgeny Berdyshev; Nicolas Coant; Magali Fradet; Paola Giussani; Irina A Gorshkova; Jonathan Goya; Nadim Kassis; Hervé Le Stunff
Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival.
Biochimica et biophysica acta 2013;1831(2):251-62.
2013: Anna Castell-Auví; Lídia Cedó; Jamileh Movassat; Victor Pallarès; Montse Pinent; Bernard Portha; Fátima Sánchez-Cabo; Mayte Blay; Anna Ardévol
Procyanidins modulate microRNA expression in pancreatic islets.
Journal of agricultural and food chemistry 2013;61(2):355-63.
2013: Audrey RIBOULET-CHAVEY; L Maulny; Jamileh Movassat; Danielle Bailbé; J P Renard; Bernard Portha
A euglycaemic/non-diabetic perinatal environment does not alleviate early beta cell maldevelopment and type 2 diabetes risk in the GK/Par rat model.
Diabetologia 2013;56(1):194-203.
2012: Florence Figeac; Anissa Ilias; Danielle Bailbe; Bernard Portha; Jamileh Movassat
Local in vivo GSK3β knockdown promotes pancreatic β cell and acinar cell regeneration in 90% pancreatectomized rat.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1944-52.
2012: Ioannis Papazoglou; Bernard Portha; Claude Rouch; Mohammed Taouis; Nicolas Vicaire; Danielle Bailbe; Flavien Berthou; Eirini M Markaki; Kyriaki Gerozissis
Hypothalamic serotonin-insulin signaling cross-talk and alterations in a type 2 diabetic model.
Molecular and cellular endocrinology 2012;350(1):136-44.
2012: Bernard Portha; Cecile Tourrel-Cuzin; Marie-Hélène Giroix; Hervé Le-Stunff; Jamileh Movassat
The GK rat: a prototype for the study of non-overweight type 2 diabetes.
Methods in molecular biology (Clifton, N.J.) 2012;933():125-59.
2011: Manuel Dolz; Magali Fradet; Marie-Hélène Giroix; Micheline Kergoat; Hervé Le Stunff; Jamileh Movassat; Danielle Bailbé; Bernard Portha
cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1.
American journal of physiology. Endocrinology and metabolism 2011;301(5):E797-806.
2011: Julien Véret; Danielle Bailbé; Evgeny Berdyshev; Nicolas Coant; Irina Gorshkova; Viswanathan Natarajan; Bernard Portha; Anastasia Skobeleva; Nicole Therville; Hervé Le Stunff
Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells.
The Biochemical journal 2011;438(1):177-89.
2011: Christophe Noll; Gregory Lacraz; Jan A Ehses; Josiane Coulaud; Danièle Bailbe; Jean-Louis Paul; Bernard Portha; Françoise Homo-Delarche; Nathalie Janel
Early reduction of circulating homocysteine levels in Goto-Kakizaki rat, a spontaneous nonobese model of type 2 diabetes.
Biochimica et biophysica acta 2011;1812(6):699-702.
2011: Bernard Portha; Audrey RIBOULET-CHAVEY; Jamileh Movassat
Early-life origins of type 2 diabetes: fetal programming of the beta-cell mass.
Experimental diabetes research 2011;2011():105076.
2011: Bernard Portha; Cécile Tourrel-Cuzin; Jamileh Movassat
Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass.
Experimental diabetes research 2011;2011():376509.
2010: Martine Desrois; Kieran Clarke; Carole Lan; Christiane Dalmasso; Mark Cole; Bernard Portha; Patrick J Cozzone; Monique Bernard
Upregulation of eNOS and unchanged energy metabolism in increased susceptibility of the aging type 2 diabetic GK rat heart to ischemic injury.
American journal of physiology. Heart and circulatory physiology 2010;299(5):H1679-86.
2010: Juan Beauquis; Françoise Homo-Delarche; Marie-Hélène Giroix; Jan Ehses; Josiane Coulaud; Paulina Roig; Bernard Portha; Alejandro F de Nicola; Flavia Saravia
Hippocampal neurovascular and hypothalamic-pituitary-adrenal axis alterations in spontaneously type 2 diabetic GK rats.
Experimental neurology 2010;222(1):125-34.
2010: Florence Figeac; Benjamin Uzan; Monique Faro; Noura Chelali; Bernard Portha; Jamileh Movassat
Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats.
American journal of physiology. Endocrinology and metabolism 2010;298(2):E245-56.
2010: Bernard Portha; Grégory Lacraz; Audrey RIBOULET-CHAVEY; Florence Figeac; Magali Fradet; Cécile Tourrel-Cuzin; Françoise Homo-Delarche; Marie-Hélène Giroix; Danielle Bailbé; Marie-Noëlle Gangnerau; Jamileh Movassat
Islet structure and function in the GK rat.
Advances in experimental medicine and biology 2010;654():479-500.
2010: Grégory Lacraz; Florence Figeac; Jamileh Movassat; Nadim Kassis; Bernard Portha
Diabetic GK/Par rat beta-cells are spontaneously protected against H2O2-triggered apoptosis. A cAMP-dependent adaptive response.
American journal of physiology. Endocrinology and metabolism 2010;298(1):E17-27.
2009: Elisa Fernández-Millán; Marie-Noëlle Gangnerau; Laura De Miguel-Santos; Sophie Calderari; Patricia Serradas; Fernando Escrivá; Bernard Portha; Carmen Alvarez
Undernutrition of the GK rat during gestation improves pancreatic IGF-2 and beta-cell mass in the fetuses.
Growth factors (Chur, Switzerland) 2009;27(6):409-18.
2009: Safia Costes; Brigitte Vandewalle; Cécile Tourrel-Cuzin; Christophe Broca; Nathalie Linck; Gyslaine Bertrand; Julie Kerr Conte; Bernard Portha; François Pattou; Joel Bockaert; Stéphane Dalle
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.
Diabetes 2009;58(5):1105-15.
2009: Grégory Lacraz; Marie-Hélène Giroix; Nadim Kassis; Josiane Coulaud; Anne Galinier; Christophe Noll; Mélanie Cornut; Fabien Schmidlin; Jean-Louis Paul; Nathalie Janel; Jean-Claude Irminger; Micheline Kergoat; Bernard Portha; Marc Y Donath; Jan A Ehses; Françoise Homo-Delarche
Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.
PloS one 2009;4(9):e6963.
2009: Grégory Lacraz; Florence Figeac; Jamileh Movassat; Nadim Kassis; Josiane Coulaud; Anne Galinier; Corinne Leloup; Danielle Bailbé; Françoise Homo-Delarche; Bernard Portha
Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses.
PloS one 2009;4(8):e6500.
2009: Benjamin Uzan; Florence Figeac; Bernard Portha; Jamileh Movassat
Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.
PloS one 2009;4(3):e4734.
2008: Jamileh Movassat; Danielle Bailbé; Cécile Lubrano-Berthelier; Françoise Picarel-Blanchot; Eric Bertin; Jacques Mourot; Bernard Portha
Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion.
American journal of physiology. Endocrinology and metabolism 2008;294(1):E168-75.
2007: Jamileh Movassat; Bernard Portha
Early administration of keratinocyte growth factor improves {beta}-cell regeneration in rat with streptozotocin-induced diabetes.
The Journal of endocrinology 2007;195(2):333-40.
2007: Jamileh Movassat; Sophie Calderari; E Fernández; M A Martín; Fernando Escrivá; Cédric Plachot; Marie-Noëlle Gangnerau; Patricia Serradas; Carmen Alvarez; Bernard Portha
Type 2 diabetes - a matter of failing beta-cell neogenesis? Clues from the GK rat model.
Diabetes, obesity & metabolism 2007;9 Suppl 2():187-95.
2007: Sophie Calderari; Marie-Noëlle Gangnerau; M Thibault; Marie-Josée Meile; Nadim Kassis; Carmen Alvarez; Bernard Portha; Patricia Serradas
Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes.
Diabetologia 2007;50(7):1463-71.
2006: Sophie Calderari; Marie-Noëlle Gangnerau; Marie-Josée Meile; Bernard Portha; Patricia Serradas
Is defective pancreatic beta-cell mass environmentally programmed in Goto-Kakizaki rat model of type 2 diabetes?: insights from crossbreeding studies during suckling period.
Pancreas 2006;33(4):412-7.
2006: Elisa Fernández; María Angeles Martín; S Fajardo; Danielle Bailbé; Marie-Noëlle Gangnerau; Bernard Portha; Fernando Escrivá; Patricia Serradas; Carmen Alvarez
Undernutrition does not alter the activation of beta-cell neogenesis and replication in adult rats after partial pancreatectomy.
American journal of physiology. Endocrinology and metabolism 2006;291(5):E913-21.
2006: Françoise Homo-Delarche; Sophie Calderari; Jean-Claude Irminger; Marie-Noëlle Gangnerau; Josiane Coulaud; Katharina Rickenbach; Manuel Dolz; Philippe A Halban; Bernard Portha; Patricia Serradas
Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat.
Diabetes 2006;55(6):1625-33.
2005: Manuel Dolz; Danielle Bailbé; Marie-Hélène Giroix; Sophie Calderari; Marie-Noëlle Gangnerau; Patricia Serradas; Katharina Rickenbach; Jean-Claude Irminger; Bernard Portha
Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production.
Diabetes 2005;54(11):3229-37.
2005: Bernard Portha
Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm.
Diabetes/metabolism research and reviews 2005;21(6):495-504.
2005: María Angeles Martín; Patricia Serradas; Sonia Ramos; Elisa Fernández; Luis Goya; Marie-Noëlle Gangnerau; Matthieu Lacorne; Ana-Maria Pascual-Leone; Fernando Escrivá; Bernard Portha; Carmen Alvarez
Protein-caloric food restriction affects insulin-like growth factor system in fetal Wistar rat.
Endocrinology 2005;146(3):1364-71.
2005: Isabelle Iltis; Frank Kober; Martine Desrois; Christiane Dalmasso; Carole Lan; Bernard Portha; Patrick J Cozzone; Monique Bernard
Defective myocardial blood flow and altered function of the left ventricle in type 2 diabetic rats: a noninvasive in vivo study using perfusion and cine magnetic resonance imaging.
Investigative radiology 2005;40(1):19-26.
2003: Bernard Portha
[Transmitted beta-cell dysfunction as a cause for type 2-diabetes].
Médecine sciences : M/S 2003;19(8-9):847-53.
2003: Jamileh Movassat; Gillian M Beattie; Ana D Lopez; Bernard Portha; Alberto Hayek
Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells.
Diabetologia 2003;46(6):822-9.
2003: Patrick C Even; Eric Bertin; Marie-Noëlle Gangnerau; Suzanne Roseau; Daniel Tome; Bernard Portha
Energy restriction with protein restriction increases basal metabolism and meal-induced thermogenesis in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(3):R751-9.
2002: Marie-Hélène Giroix; Olivier Scruel; Philippe Courtois; Abdullah Sener; Bernard Portha; Willy J Malaisse
Comparison between D-[3-3H]- and D-[5-3H]glucose and fructose utilization in pancreatic islets from control and hereditarily diabetic rats.
Archives of biochemistry and biophysics 2002;408(1):111-23.
2002: Eric Bertin; Marie-Noëlle Gangnerau; Georges Bellon; Danielle Bailbé; Annick Arbelot De Vacqueur; Bernard Portha
Development of beta-cell mass in fetuses of rats deprived of protein and/or energy in last trimester of pregnancy.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(3):R623-30.
2002: Cécile Tourrel; Danielle Bailbe; Matthieu Lacorne; Marie-Josée Meile; Micheline Kergoat; Bernard Portha
Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.
Diabetes 2002;51(5):1443-52.
2002: Marie-Hélène Giroix; Abdellatif Bakkali Nadi; Abdullah Sener; Bernard Portha; Willy J Malaisse
Metabolism of D-[3-3H]glucose, D-[5-3H]glucose, D-[U-14C]glucose, D-[1-14C]glucose and D-[6-14C]glucose in pancreatic islets in an animal model of type-2 diabetes.
International journal of molecular medicine 2002;9(4):381-4.
2002: Patricia Serradas; Luis Goya; Matthieu Lacorne; Marie-Noëlle Gangnerau; Sonia Ramos; Carmen Alvarez; Ana-Maria Pascual-Leone; Bernard Portha
Fetal insulin-like growth factor-2 production is impaired in the GK rat model of type 2 diabetes.
Diabetes 2002;51(2):392-7.
2001: Cédric Plachot; Jamileh Movassat; Bernard Portha
Impaired beta-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetes.
Histochemistry and cell biology 2001;116(2):131-9.
2001: C Tourrel; Danielle Bailbé; Marie-Josée Meile; Micheline Kergoat; Bernard Portha
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.
Diabetes 2001;50(7):1562-70.
2001: JC Marie; Danielle Bailbé; E Gylfe; Bernard Portha
Defective glucose-dependent cytosolic Ca2+ handling in islets of GK and nSTZ rat models of type 2 diabetes.
The Journal of endocrinology 2001;169(1):169-76.
2001: Cédric Plachot; Bernard Portha
Impaired pancreatic duct-cell growth in focal areas of regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of non-insulin dependent diabetes mellitus.
The Histochemical journal 2001;33(3):141-7.
2001: Bernard Portha; Marie-Hélène Giroix; Patricia Serradas; Marie-Noëlle Gangnerau; Jamileh Movassat; Fabienne Rajas; Danielle Bailbe; Cédric Plachot; Gilles Mithieux; JC Marie
beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony.
Diabetes 2001;50 Suppl 1():S89-93.
2001: F Miralles; Bernard Portha
Early development of beta-cells is impaired in the GK rat model of type 2 diabetes.
Diabetes 2001;50 Suppl 1():S84-8.
2000: Carmen Alvarez; Danielle Bailbe; F Picarel-Blanchot; Eric Bertin; Ana-Maria Pascual-Leone; Bernard Portha
Effect of early dietary restriction on insulin action and secretion in the GK rat, a spontaneous model of NIDDM.
American journal of physiology. Endocrinology and metabolism 2000;278(6):E1097-103.
2000: Isabelle Briaud; Christine Rouault; Danielle Bailbé; Bernard Portha; Gérard Reach; Vincent Poitout
Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(3):103-6.
2000: Isabelle Briaud; Christine Rouault; Danielle Bailbé; Bernard Portha; Gérard Reach; Vincent Poitout
Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(2):53-6.
1999: Marie-Hélène Giroix; Olivier Scruel; L Ladriere; Abdullah Sener; Bernard Portha; Willy J Malaisse
Metabolic and secretory interactions between D-glucose and D-fructose in islets from GK rats.
Endocrinology 1999;140(12):5556-65.
1999: Olivier Scruel; Marie-Hélène Giroix; Abdullah Sener; Bernard Portha; Willy J Malaisse
Metabolic and secretory response to D-fructose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period.
Molecular genetics and metabolism 1999;68(1):86-90.
1999: Jamileh Movassat; Bernard Portha
Beta-cell growth in the neonatal Goto-Kakisaki rat and regeneration after treatment with streptozotocin at birth.
Diabetologia 1999;42(9):1098-106.
1999: Marie-Hélène Giroix; C Saulnier; Bernard Portha
Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: enzymatic, metabolic and secretory data.
Diabetologia 1999;42(8):965-77.
1999: Eric Bertin; Marie-Noëlle Gangnerau; Danielle Bailbé; Bernard Portha
Glucose metabolism and beta-cell mass in adult offspring of rats protein and/or energy restricted during the last week of pregnancy.
The American journal of physiology 1999;277(1 Pt 1):E11-7.
1999: stephane frayon; Marcia Pessah; Marie-Hélène Giroix; Dany Mercan; C Boissard; Willy J Malaisse; Bernard Portha; Jean-Michel Garel
Galphaolf identification by RT-PCR in purified normal pancreatic B cells and in islets from rat models of non-insulin-dependent diabetes.
Biochemical and biophysical research communications 1999;254(1):269-72.
1999: Bernard Portha; Jamileh Movassat; Cédric Plachot; C Saulnier
[Growth and regeneration potential abnormalities of pancreatic beta-cells in GK rats, NIDDM mellitus model].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1999;():25-38.
1998: N Dachicourt; Danielle Bailbé; Marie-Noëlle Gangnerau; Patricia Serradas; D Ravel; Bernard Portha
Effect of gliclazide treatment on insulin secretion and beta-cell mass in non-insulin dependent diabetic Goto-Kakisaki rats.
European journal of pharmacology 1998;361(2-3):243-51.
1998: Eric Bertin; J C Ruiz; Jacques Mourot; Philippe Peiniau; Bernard Portha
Evaluation of dual-energy X-Ray absorptiometry for body-composition assessment in rats.
The Journal of nutrition 1998;128(9):1550-4.
1998: T Leon-Quinto; Christophe Magnan; Bernard Portha
Altered activity of the autonomous nervous system as a determinant of the impaired beta-cell secretory response after protein-energy restriction in the rat.
Endocrinology 1998;139(8):3382-9.
1998: C Bernard; C Thibault; Marie-France Berthault; Christophe Magnan; C Saulnier; Bernard Portha; W F Pralong; Luc Pénicaud; Alain Ktorza
Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.
Diabetes 1998;47(7):1058-65.
1998: Patricia Serradas; Marie-Noëlle Gangnerau; Marie-Hélène Giroix; C Saulnier; Bernard Portha
Impaired pancreatic beta cell function in the fetal GK rat. Impact of diabetic inheritance.
The Journal of clinical investigation 1998;101(4):899-904.
1997: N Dachicourt; Patricia Serradas; Danielle Bailbé; Micheline Kergoat; L Doaré; Bernard Portha
Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies.
The Journal of endocrinology 1997;155(2):369-76.
1997: T Leon-Quinto; P Adnot; Bernard Portha
Alteration of the counterregulatory hormones in the conscious rat after protein-energy restriction.
Diabetologia 1997;40(9):1028-34.
1997: Jamileh Movassat; C Saulnier; Bernard Portha
Insulin administration enhances growth of the beta-cell mass in streptozotocin-treated newborn rats.
Diabetes 1997;46(9):1445-52.
1997: Jamileh Movassat; C Saulnier; Patricia Serradas; Bernard Portha
Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat.
Diabetologia 1997;40(8):916-25.
1997: C Berthelier; Micheline Kergoat; Bernard Portha
Lack of deterioration of insulin action with aging in the GK rat: a contrasted adaptation as compared with nondiabetic rats.
Metabolism: clinical and experimental 1997;46(8):890-6.
1997: Marie-Hélène Giroix; F Malaisse-Lagae; Bernard Portha; Abdullah Sener; Willy J Malaisse
Effects of dehydroepiandrosterone in rats injected with streptozotocin during the neonatal period.
Biochemical and molecular medicine 1997;61(1):72-81.
1997: Carmen Alvarez; María Angeles Martín; Luis Goya; Eric Bertin; Bernard Portha; Ana-Maria Pascual-Leone
Contrasted impact of maternal rat food restriction on the fetal endocrine pancreas.
Endocrinology 1997;138(6):2267-73.
1997: L Morin; Marie-Hélène Giroix; Marie-Noëlle Gangnerau; Danielle Bailbé; Bernard Portha
Impaired phosphoinositide metabolism in glucose-incompetent islets of neonatally streptozotocin-diabetic rats.
The American journal of physiology 1997;272(5 Pt 1):E737-45.
1997: María Angeles Martín; Carmen Alvarez; Luis Goya; Bernard Portha; Ana-Maria Pascual-Leone
Insulin secretion in adult rats that had experienced different underfeeding patterns during their development.
The American journal of physiology 1997;272(4 Pt 1):E634-40.
1997: María A Tormo; Danielle Bailbé; Patricia Serradas; C Saulnier; Bernard Portha; José E Campillo
Transplantation of syngenic pancreatic islets into rats with streptozotocin induced non insulin dependent diabetes mellitus.
Advances in experimental medicine and biology 1997;426():441-5.
1997: María A Tormo; T Leon-Quinto; C Saulnier; Danielle Bailbe; Patricia Serradas; Bernard Portha
Insulin secretion and glucose tolerance after islet transplantation in rats with noninsulin-dependent diabetes induced by neonatal streptozotocin.
Cell transplantation 1997;6(1):23-32.
1996: L Morin; Marie-Hélène Giroix; Bernard Portha
Decreased ATP-induced synthesis and Ca(2+)-stimulated degradation of polyphosphoinositides in pancreatic islets from neonatally streptozotocin-diabetic rats.
Biochemical and biophysical research communications 1996;228(2):573-8.
1996: F Picarel-Blanchot; C Berthelier; Danielle Bailbé; Bernard Portha
Impaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat.
The American journal of physiology 1996;271(4 Pt 1):E755-62.
1996: N Dachicourt; Patricia Serradas; Marie-Hélène Giroix; Marie-Noëlle Gangnerau; Bernard Portha
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP.
The American journal of physiology 1996;271(4 Pt 1):E725-32.
1996: Bernard Portha; Alain Ktorza
[Glucotoxicity and insulin secretion. An excessively reductionistic formulation].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1996;():121-31.
1996: Dominique Gauguier; philippe froguel; V Parent; C Bernard; Marie-Thérèse Bihoreau; Bernard Portha; Michael R James; L Penicaud; Mark Lathrop; A Ktorza
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.
Nature genetics 1996;12(1):38-43.
1995: F Picarel-Blanchot; C Alvarez; D Bailbe; A M Pascual-Leone; Bernard Portha
Changes in insulin action and insulin secretion in the rat after dietary restriction early in life: influence of food restriction versus low-protein food restriction.
Metabolism: clinical and experimental 1995;44(12):1519-26.
1995: Jamileh Movassat; C Saulnier; Bernard Portha
Beta-cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin-dependent diabetes mellitus.
Diabète & métabolisme 1995;21(5):365-70.
1995: Patricia Serradas; Marie-Hélène Giroix; C Saulnier; Marie-Noëlle Gangnerau; L A Borg; M Welsh; Bernard Portha; N Welsh
Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of noninsulin-dependent diabetes.
Endocrinology 1995;136(12):5623-31.
1995: Marie-Hélène Giroix; T M Zhang; V Leclercq-Meyer; Abdullah Sener; Bernard Portha; Willy J Malaisse
Restricted effect of formycin A and non-glucidic nutrients upon insulin release in islets from rats with hereditary or acquired non-insulin-dependent diabetes.
Acta diabetologica 1995;32(3):198-202.
1995: Bernard Portha; Micheline Kergoat; O Blondel; D Bailbe
Underfeeding of rat mothers during the first two trimesters of gestation does not alter insulin action and insulin secretion in the progeny.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(4):475-82.
1995: P Marfaing-Jallat; Bernard Portha; Luc Pénicaud
Altered conditioned taste aversion and glucose utilization in related brain nuclei of diabetic GK rats.
Brain research bulletin 1995;37(6):639-43.
1994: Marie-Hélène Giroix; Abdullah Sener; Bernard Portha; Willy J Malaisse
Enzymatic and secretory activities in pancreatic islets of non-insulin-dependent diabetic rats after short-term infusion of succinic acid monomethyl ester.
Biochemical medicine and metabolic biology 1994;53(2):115-21.
1994: F Picarel-Blanchot; Danielle Bailbé; Bernard Portha
d-Fenfluramine improves hepatic insulin action in streptozotocin-diabetic rats.
European journal of pharmacology 1994;264(2):227-32.
1994: Joanne Rasschaert; Marie-Hélène Giroix; Ignacio Conget; Dany Mercan; V Leclercq-Meyer; Abdullah Sener; Bernard Portha; Willy J Malaisse
Pancreatic islet response to dicarboxylic acid esters in rats with type 2 diabetes: enzymatic, metabolic and secretory aspects.
Journal of molecular endocrinology 1994;13(2):209-17.
1994: N Atef; Bernard Portha; Luc Pénicaud
Changes in islet blood flow in rats with NIDDM.
Diabetologia 1994;37(7):677-80.
1994: Bernard Portha; Marie-Hélène Giroix; Patricia Serradas; L Morin; C Saulnier; D Bailbe
Glucose refractoriness of pancreatic beta-cells in rat models of non-insulin dependent diabetes.
Diabète & métabolisme 1994;20(2):108-15.
1993: Marie-Hélène Giroix; Abdullah Sener; D Bailbe; V Leclercq-Meyer; Bernard Portha; Willy J Malaisse
Metabolic, ionic, and secretory response to D-glucose in islets from rats with acquired or inherited non-insulin-dependent diabetes.
Biochemical medicine and metabolic biology 1993;50(3):301-21.
1993: Bernard Portha; Patricia Serradas; Danielle Bailbé; O Blondel; F Picarel
Effect of benfluorex on insulin secretion and insulin action in streptozotocin-diabetic rats.
Diabetes/metabolism reviews 1993;9 Suppl 1():57S-63S.
1993: S Bisbis; D Bailbe; María A Tormo; F Picarel-Blanchot; Michel Derouet; J Simon; Bernard Portha
Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver.
The American journal of physiology 1993;265(5 Pt 1):E807-13.
1993: C Thibault; C Guettet; M C Laury; J M N'Guyen; María A Tormo; Danielle Bailbé; Bernard Portha; Luc Pénicaud; Alain Ktorza
In vivo and in vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48-h hyperglycaemic period.
Diabetologia 1993;36(7):589-95.
1993: Abdullah Sener; Marie-Hélène Giroix; F Malaisse-Lagae; D Bailbe; V Leclercq-Meyer; Bernard Portha; Willy J Malaisse
Metabolic response to nonglucidic nutrient secretagogues and enzymatic activities in pancreatic islets of adult rats after neonatal streptozotocin administration.
Biochemical medicine and metabolic biology 1993;49(2):182-99.
1993: Marie-Hélène Giroix; Abdullah Sener; Bernard Portha; Willy J Malaisse
Preferential alteration of oxidative relative to total glycolysis in pancreatic islets of two rat models of inherited or acquired type 2 (non-insulin-dependent) diabetes mellitus.
Diabetologia 1993;36(4):305-9.
1993: Patricia Serradas; O Blondel; D Bailbe; Bernard Portha
Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats.
Diabetes 1993;42(4):564-70.
1993: Marie-Hélène Giroix; L Vesco; Bernard Portha
Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes.
Endocrinology 1993;132(2):815-22.
1992: F Escrivá; C Rodríguez; J Cacho; Carmen Alvarez; Bernard Portha; Ana-Maria Pascual-Leone
Glucose utilization and insulin action in adult rats submitted to prolonged food restriction.
The American journal of physiology 1992;263(1 Pt 1):E1-7.
1992: C Thibault; M C Laury; D Bailbe; Alain Ktorza; Bernard Portha
Effect of prolonged in vivo glucose infusion on insulin secretion in rats with previous glucose intolerance.
Endocrinology 1992;130(5):2521-7.
1992: Marie-Hélène Giroix; D Baetens; Joanne Rasschaert; V Leclercq-Meyer; Abdullah Sener; Bernard Portha; Willy J Malaisse
Enzymic and metabolic anomalies in islets of diabetic rats: relationship to B cell mass.
Endocrinology 1992;130(5):2634-40.
1992: Marie-Hélène Giroix; Joanne Rasschaert; Abdullah Sener; V Leclercq-Meyer; D Bailbe; Bernard Portha; Willy J Malaisse
Study of hexose transport, glycerol phosphate shuttle and Krebs cycle in islets of adult rats injected with streptozotocin during the neonatal period.
Molecular and cellular endocrinology 1992;83(2-3):95-104.
1991: Willy J Malaisse; Marie-Hélène Giroix; D Zähner; G Marynissen; Abdullah Sener; Bernard Portha
Neonatal streptozotocin injection: a model of glucotoxicity?
Metabolism: clinical and experimental 1991;40(10):1101-5.
1991: F Escriva; Micheline Kergoat; Danielle Bailbé; Ana-Maria Pascual-Leone; Bernard Portha
Increased insulin action in the rat after protein malnutrition early in life.
Diabetologia 1991;34(8):559-64.
1991: M C Laury; F Takao; D Bailbe; L Penicaud; Bernard Portha; L Picon; Alain Ktorza
Differential effects of prolonged hyperglycemia on in vivo and in vitro insulin secretion in rats.
Endocrinology 1991;128(5):2526-33.
1991: Bernard Portha; Patricia Serradas; Danielle Bailbé; K Suzuki; Y Goto; Marie-Hélène Giroix
Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes.
Diabetes 1991;40(4):486-91.
1991: Micheline Kergoat; Michèle Guerre-Millo; M Lauva; Bernard Portha
Increased insulin action in rats with mild insulin deficiency induced by neonatal streptozotocin.
The American journal of physiology 1991;260(4 Pt 1):E561-7.
1991: Marie-Hélène Giroix; Joanne Rasschaert; D Bailbe; V Leclercq-Meyer; A Sener; Bernard Portha; W J Malaisse
Impairment of glycerol phosphate shuttle in islets from rats with diabetes induced by neonatal streptozocin.
Diabetes 1991;40(2):227-32.
1991: Patricia Serradas; Danielle Bailbé; O Blondel; Bernard Portha
Abnormal B-cell function in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin: effect of in vivo insulin, phlorizin, or vanadate treatments.
Pancreas 1991;6(1):54-62.
1990: Marie-Hélène Giroix; Abdullah Sener; D Bailbe; Bernard Portha; Willy J Malaisse
Impairment of the mitochondrial oxidative response to D-glucose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period.
Diabetologia 1990;33(11):654-60.
1990: O Blondel; D Bailbe; Bernard Portha
Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment.
Metabolism: clinical and experimental 1990;39(8):787-93.
1990: O Blondel; J Simon; B Chevalier; Bernard Portha
Impaired insulin action but normal insulin receptor activity in diabetic rat liver: effect of vanadate.
The American journal of physiology 1990;258(3 Pt 1):E459-67.
1989: O Blondel; Bernard Portha
Early appearance of in vivo insulin resistance in adult streptozotocin-injected rats.
Diabète & métabolisme 1989;15(6):382-7.
1989: Marie-Hélène Giroix; Patricia Serradas; Bernard Portha
The desensitization of normal B-cells to glucose in vitro is transient and not related to high glucose levels.
Endocrinology 1989;125(4):1999-2007.
1989: Patricia Serradas; Danielle Bailbé; Bernard Portha
Long-term gliclazide treatment improves the in vitro glucose-induced insulin release in rats with type 2 (non-insulin-dependent) diabetes induced by neonatal streptozotocin.
Diabetologia 1989;32(8):577-84.
1989: O Blondel; Danielle Bailbé; Bernard Portha
Relation of insulin deficiency to impaired insulin action in NIDDM adult rats given streptozocin as neonates.
Diabetes 1989;38(5):610-7.
1989: O Blondel; D Bailbe; Bernard Portha
In vivo insulin resistance in streptozotocin-diabetic rats--evidence for reversal following oral vanadate treatment.
Diabetologia 1989;32(3):185-90.
1989: Bernard Portha; O Blondel; Patricia Serradas; R McEvoy; Marie-Hélène Giroix; Micheline Kergoat; D Bailbe
The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin.
Diabète & métabolisme 1989;15(2):61-75.
1989: Patricia Serradas; Marie-Hélène Giroix; Bernard Portha
Evaluation of the pancreatic B-cell function in the rat after prenatal exposure to streptozotocin or N-nitrosomethylurea.
Diabète & métabolisme 1989;15(1):30-7.
1988: Bernard Portha; Marie-Hélène Giroix; Patricia Serradas; N Welsh; C Hellerström; Abdullah Sener; Willy J Malaisse
Insulin production and glucose metabolism in isolated pancreatic islets of rats with NIDDM.
Diabetes 1988;37(9):1226-33.
1988: Micheline Kergoat; J Simon; Bernard Portha
Insulin binding and insulin receptor tyrosine kinase activity are not altered in the liver of rats with non-insulin-dependent diabetes.
Biochemical and biophysical research communications 1988;152(3):1015-22.
1988: Bernard Portha; Marie-Hélène Giroix; Micheline Kergoat; D Bailbe; O Blondel; Patricia Serradas
[Animal models of non-insulin-dependent diabetes induced in the rat by experimental reduction of B cell mass].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1988;():33-46.
1987: Micheline Kergoat; D Bailbe; Bernard Portha
Effect of high sucrose diet on insulin secretion and insulin action. A study in rats with non-insulin-dependent diabetes induced by streptozotocin.
Diabetologia 1987;30(8):666-73.
1987: Micheline Kergoat; D Bailbe; Bernard Portha
Insulin treatment improves glucose-induced insulin release in rats with NIDDM induced by streptozocin.
Diabetes 1987;36(8):971-7.
1987: Micheline Kergoat; Danielle Bailbé; Bernard Portha
Effect of high sucrose diet on insulin secretion and insulin action: a study in the normal rat.
Diabetologia 1987;30(4):252-8.
1986: Micheline Kergoat; Marie-Hélène Giroix; Bernard Portha
Evidence for normal in vitro Ca2+-stimulated insulin release in rats with non-insulin-dependent diabetes.
Diabète & métabolisme 1986;12(2):79-82.
1985: Micheline Kergoat; Bernard Portha; L Picon
Effect of exogenous insulin on glucose kinetics in rats with noninsulin-dependent diabetes.
Metabolism: clinical and experimental 1985;34(4):377-82.
1984: Marie-Hélène Giroix; Bernard Portha; Micheline Kergoat; L Picon
Glucagon secretion in rats with non-insulin-dependent diabetes: an in vivo and in vitro study.
Diabète & métabolisme 1984;10(1):12-7.
1983: Marie-Hélène Giroix; Bernard Portha; Micheline Kergoat; D Bailbe; L Picon
Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes. A study with the perfused pancreas.
Diabetes 1983;32(5):445-51.