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Daniel Portnoy

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Disorders

Listeria Infections

Chemicals & Drugs

Anatomy

Concepts & Ideas

Physiology

Mutation

Genes & Molecular Sequences

Bacterial Genes

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Co-Publications
Name
8
Auerbuch, Victoria
6
Dubensky, Thomas
5
Herskovits, Anat
5
Bouwer, Archie
5
Brockstedt, Dirk
5
O'Riordan, Mary
4
Liu, Weiqun
4
Meyer-Morse, Nicole
4
Moors, Marlena
4
Schnupf, Pamela
4
Skoble, J
4
Higgins, Darren
4
Goldfine, Howard
4
Welch, Matt
4
Bahjat, Keith

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Publications

TOP 3
Bahjat Keith S; Meyer-Morse Nicole; Lemmens Edward E; Shugart Jessica A; Dubensky Thomas W; Brockstedt Dirk G; Portnoy Daniel A
Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria.
Vance Russell E; Isberg Ralph R; Portnoy Daniel A
Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.
Crimmins Gregory T; Schelle Michael W; Herskovits Anat A; Ni Peggy P; Kline Benjamin C; Meyer-Morse Nicole; Iavarone Anthony T; Portnoy Daniel A
Listeria monocytogenes 6-Phosphogluconolactonase mutants induce increased activation of a host cytosolic surveillance pathway.

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All Publications

2009: Bahjat Keith S; Meyer-Morse Nicole; Lemmens Edward E; Shugart Jessica A; Dubensky Thomas W; Brockstedt Dirk G; Portnoy Daniel A
Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria.
PLoS pathogens 2009;5(9):e1000568.
2009: Vance Russell E; Isberg Ralph R; Portnoy Daniel A
Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.
Cell host & microbe 2009;6(1):10-21.
2009: Crimmins Gregory T; Schelle Michael W; Herskovits Anat A; Ni Peggy P; Kline Benjamin C; Meyer-Morse Nicole; Iavarone Anthony T; Portnoy Daniel A
Listeria monocytogenes 6-Phosphogluconolactonase mutants induce increased activation of a host cytosolic surveillance pathway.
Infection and immunity 2009;77(7):3014-22.
2009: Zemansky Jason; Kline Benjamin C; Woodward Joshua J; Leber Jess H; Marquis Hélène; Portnoy Daniel A
Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-prolyl isomerase PrsA2, that contribute to its hemolytic phenotype.
Journal of bacteriology 2009;191(12):3950-64.
2008: Crimmins Gregory T; Herskovits Anat A; Rehder Kai; Sivick Kelsey E; Lauer Peter; Dubensky Thomas W; Portnoy Daniel A
Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10191-6.
2008: Viala Julie P M; Mochegova Sofia N; Meyer-Morse Nicole; Portnoy Daniel A
A bacterial pore-forming toxin forms aggregates in cells that resemble those associated with neurodegenerative diseases.
Cellular microbiology 2008;10(4):985-93.
2008: Leber Jess H; Crimmins Gregory T; Raghavan Sridharan; Meyer-Morse Nicole P; Cox Jeffery S; Portnoy Daniel A
Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen.
PLoS pathogens 2008;4(1):e6.
2007: Bahjat Keith S; Prell Rodney A; Allen Heather E; Liu Weiqun; Lemmens Edward E; Leong Meredith L; Portnoy Daniel A; Dubensky Thomas W; Brockstedt Dirk G; Giedlin Martin A
Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7376-84.
2007: Schnupf Pamela; Zhou Jianmin; Varshavsky Alexander; Portnoy Daniel A
Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway.
Infection and immunity 2007;75(11):5135-47.
2007: Schnupf Pamela; Portnoy Daniel A
Listeriolysin O: a phagosome-specific lysin.
Microbes and infection / Institut Pasteur 2007;9(10):1176-87.
2007: Herskovits Anat A; Auerbuch Victoria; Portnoy Daniel A
Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system.
PLoS pathogens 2007;3(3):e51.
2006: Bahjat Keith S; Liu Weiqun; Lemmens Edward E; Schoenberger Stephen P; Portnoy Daniel A; Dubensky Thomas W; Brockstedt Dirk G
Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Infection and immunity 2006;74(11):6387-97.
2006: Bakardjiev Anna I; Theriot Julie A; Portnoy Daniel A
Listeria monocytogenes traffics from maternal organs to the placenta and back.
PLoS pathogens 2006;2(6):e66.
2006: Schnupf Pamela; Portnoy Daniel A; Decatur Amy L
Phosphorylation, ubiquitination and degradation of listeriolysin O in mammalian cells: role of the PEST-like sequence.
Cellular microbiology 2006;8(2):353-64.
2006: Tabeta Koichi; Hoebe Kasper; Janssen Edith M; Du Xin; Georgel Philippe; Crozat Karine; Mudd Suzanne; Mann Navjiwan; Sovath Sosathya; Goode Jason; Shamel Louis; Herskovits Anat A; Portnoy Daniel A; Cooke Michael; Tarantino Lisa M; Wiltshire Tim; Steinberg Benjamin E; Grinstein Sergio; Beutler Bruce
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Nature immunology 2006;7(2):156-64.
2005: Cheng Luisa W; Viala Julie P M; Stuurman Nico; Wiedemann Ursula; Vale Ronald D; Portnoy Daniel A
Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13646-51.
2005: Brockstedt D G; Bahjat K S; Giedlin M A; Liu W; Leong M; Luckett W; Gao Y; Schnupf P; Kapadia D; Castro G; Lim J Y H; Sampson-Johannes A; Herskovits A A; Stassinopoulos A; Bouwer H G Archie; Hearst J E; Portnoy D A; Cook D N; Dubensky T W
Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity.
Nature medicine 2005;11(8):853-60.
2005: Bakardjiev Anna I; Stacy Brian A; Portnoy Daniel A
Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection.
The Journal of infectious diseases 2005;191(11):1889-97.
2005: Portnoy Daniel A
Manipulation of innate immunity by bacterial pathogens.
Current opinion in immunology 2005;17(1):25-8.
2004: Brockstedt Dirk G; Giedlin Martin A; Leong Meredith L; Bahjat Keith S; Gao Yi; Luckett William; Liu Weiqun; Cook David N; Portnoy Daniel A; Dubensky Thomas W
Listeria-based cancer vaccines that segregate immunogenicity from toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13832-7.
2004: Auerbuch Victoria; Brockstedt Dirk G; Meyer-Morse Nicole; O'Riordan Mary; Portnoy Daniel A
Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.
The Journal of experimental medicine 2004;200(4):527-33.
2004: McCaffrey Ramona L; Fawcett Paul; O'Riordan Mary; Lee Kyung-Dall; Havell Edward A; Brown Patrick O; Portnoy Daniel A
A specific gene expression program triggered by Gram-positive bacteria in the cytosol.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(31):11386-91.
2004: Bakardjiev Anna I; Stacy Brian A; Fisher Susan J; Portnoy Daniel A
Listeriosis in the pregnant guinea pig: a model of vertical transmission.
Infection and immunity 2004;72(1):489-97.
2003: Cheng Luisa W; Portnoy Daniel A
Drosophila S2 cells: an alternative infection model for Listeria monocytogenes.
Cellular microbiology 2003;5(12):875-85.
2003: Glomski Ian J; Decatur Amy L; Portnoy Daniel A
Listeria monocytogenes mutants that fail to compartmentalize listerolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses.
Infection and immunity 2003;71(12):6754-65.
2003: O'Riordan Mary; Moors Marlena A; Portnoy Daniel A
Listeria intracellular growth and virulence require host-derived lipoic acid.
Science (New York, N.Y.) 2003;302(5644):462-4.
2003: Lenz Laurel L; Mohammadi Sina; Geissler Aimee; Portnoy Daniel A
SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12432-7.
2003: Auerbuch Victoria; Loureiro Joseph J; Gertler Frank B; Theriot Julie A; Portnoy Daniel A
Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility.
Molecular microbiology 2003;49(5):1361-75.
2002: Dancz Christina E; Haraga Andrea; Portnoy Daniel A; Higgins Darren E
Inducible control of virulence gene expression in Listeria monocytogenes: temporal requirement of listeriolysin O during intracellular infection.
Journal of bacteriology 2002;184(21):5935-45.
2002: O'Riordan Mary; Yi Caroline H; Gonzales Ramona; Lee Kyung-Dall; Portnoy Daniel A
Innate recognition of bacteria by a macrophage cytosolic surveillance pathway.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13861-6.
2002: Lenz Laurel L; Portnoy Daniel A
Identification of a second Listeria secA gene associated with protein secretion and the rough phenotype.
Molecular microbiology 2002;45(4):1043-56.
2002: Portnoy Daniel A; Auerbuch Victoria; Glomski Ian J
The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity.
The Journal of cell biology 2002;158(3):409-14.
2002: O'Riordan Mary; Portnoy Daniel A
The host cytosol: front-line or home front?
Trends in microbiology 2002;10(8):361-4.
2002: Lauer Peter; Chow Man Yin Nora; Loessner Martin J; Portnoy Daniel A; Calendar Richard
Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors.
Journal of bacteriology 2002;184(15):4177-86.
2002: Auerbuch Victoria; Portnoy Daniel A
Microbial pathogenesis and the eukaryotic cytoskeleton at the American Society for Cell Biology annual meeting.
Cellular microbiology 2002;4(3):187-90.
2002: Glomski Ian J; Gedde Margaret M; Tsang Albert W; Swanson Joel A; Portnoy Daniel A
The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells.
The Journal of cell biology 2002;156(6):1029-38.
2001: Lauer P; Theriot J A; Skoble J; Welch M D; Portnoy D A
Systematic mutational analysis of the amino-terminal domain of the Listeria monocytogenes ActA protein reveals novel functions in actin-based motility.
Molecular microbiology 2001;42(5):1163-77.
2001: Skoble J; Auerbuch V; Goley E D; Welch M D; Portnoy D A
Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility.
The Journal of cell biology 2001;155(1):89-100.
2001: Auerbuch V; Lenz L L; Portnoy D A
Development of a competitive index assay to evaluate the virulence of Listeria monocytogenes actA mutants during primary and secondary infection of mice.
Infection and immunity 2001;69(9):5953-7.
2000: Decatur A L; Portnoy D A
A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity.
Science (New York, N.Y.) 2000;290(5493):992-5.
2000: Skoble J; Portnoy D A; Welch M D
Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and Listeria monocytogenes motility.
The Journal of cell biology 2000;150(3):527-38.
2000: Gedde M M; Higgins D E; Tilney L G; Portnoy D A
Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenes.
Infection and immunity 2000;68(2):999-1003.
1999: Moors M A; Auerbuch V; Portnoy D A
Stability of the Listeria monocytogenes ActA protein in mammalian cells is regulated by the N-end rule pathway.
Cellular microbiology 1999;1(3):249-57.
1999: Higgins D E; Shastri N; Portnoy D A
Delivery of protein to the cytosol of macrophages using Escherichia coli K-12.
Molecular microbiology 1999;31(6):1631-41.
1999: Moors M A; Levitt B; Youngman P; Portnoy D A
Expression of listeriolysin O and ActA by intracellular and extracellular Listeria monocytogenes.
Infection and immunity 1999;67(1):131-9.
1998: Thompson R J; Bouwer H G; Portnoy D A; Frankel F R
Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth.
Infection and immunity 1998;66(8):3552-61.
1998: Welch M D; Rosenblatt J; Skoble J; Portnoy D A; Mitchison T J
Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.
Science (New York, N.Y.) 1998;281(5373):105-8.
1998: Higgins D E; Portnoy D A
Bacterial delivery of DNA evolves.
Nature biotechnology 1998;16(2):138-9.
1997: Marquis H; Goldfine H; Portnoy D A
Proteolytic pathways of activation and degradation of a bacterial phospholipase C during intracellular infection by Listeria monocytogenes.
The Journal of cell biology 1997;137(6):1381-92.
1996: Smith G A; Theriot J A; Portnoy D A
The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin.
The Journal of cell biology 1996;135(3):647-60.
1996: Jones S; Preiter K; Portnoy D A
Conversion of an extracellular cytolysin into a phagosome-specific lysin which supports the growth of an intracellular pathogen.
Molecular microbiology 1996;21(6):1219-25.
1995: Marquis H; Doshi V; Portnoy D A
The broad-range phospholipase C and a metalloprotease mediate listeriolysin O-independent escape of Listeria monocytogenes from a primary vacuole in human epithelial cells.
Infection and immunity 1995;63(11):4531-4.
1995: Smith G A; Marquis H; Jones S; Johnston N C; Portnoy D A; Goldfine H
The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread.
Infection and immunity 1995;63(11):4231-7.
1995: Smith G A; Portnoy D A; Theriot J A
Asymmetric distribution of the Listeria monocytogenes ActA protein is required and sufficient to direct actin-based motility.
Molecular microbiology 1995;17(5):945-51.
1995: Moors M A; Portnoy D A
Identification of bacterial genes that contribute to survival and growth in an intracellular environment.
Trends in microbiology 1995;3(3):83-5.
1994: Ikonomidis G; Paterson Y; Kos F J; Portnoy D A
Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.
The Journal of experimental medicine 1994;180(6):2209-18.
1994: Jones S; Portnoy D A
Characterization of Listeria monocytogenes pathogenesis in a strain expressing perfringolysin O in place of listeriolysin O.
Infection and immunity 1994;62(12):5608-13.
1994: Portnoy D A; Jones S
The cell biology of Listeria monocytogenes infection (escape from a vacuole).
Annals of the New York Academy of Sciences 1994;730():15-25.
1994: Freitag N E; Portnoy D A
Dual promoters of the Listeria monocytogenes prfA transcriptional activator appear essential in vitro but are redundant in vivo.
Molecular microbiology 1994;12(5):845-53.
1994: Theriot J A; Rosenblatt J; Portnoy D A; Goldschmidt-Clermont P J; Mitchison T J
Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts.
Cell 1994;76(3):505-17.
1994: Portnoy D A; Smith G A; Goldfine H
Phospholipases C and the pathogenesis of Listeria.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):357-61.
1993: Brundage R A; Smith G A; Camilli A; Theriot J A; Portnoy D A
Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11890-4.
1993: Marquis H; Bouwer H G; Hinrichs D J; Portnoy D A
Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants.
Infection and immunity 1993;61(9):3756-60.
1993: Smith G A; Portnoy D A
The role of two phospholipases in the pathogenicity of Listeria monocytogenes.
Infectious agents and disease 1993;2(4):183-5.
1993: Freitag N E; Rong L; Portnoy D A
Regulation of the prfA transcriptional activator of Listeria monocytogenes: multiple promoter elements contribute to intracellular growth and cell-to-cell spread.
Infection and immunity 1993;61(6):2537-44.
1993: Camilli A; Tilney L G; Portnoy D A
Dual roles of plcA in Listeria monocytogenes pathogenesis.
Molecular microbiology 1993;8(1):143-57.
1992: Portnoy D A; Tweten R K; Kehoe M; Bielecki J
Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells.
Infection and immunity 1992;60(7):2710-7.
1992: Bouwer H G; Nelson C S; Gibbins B L; Portnoy D A; Hinrichs D J
Listeriolysin O is a target of the immune response to Listeria monocytogenes.
The Journal of experimental medicine 1992;175(6):1467-71.
1992: Theriot J A; Mitchison T J; Tilney L G; Portnoy D A
The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization.
Nature 1992;357(6375):257-60.
1992: Barry R A; Bouwer H G; Portnoy D A; Hinrichs D J
Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread.
Infection and immunity 1992;60(4):1625-32.
1992: Portnoy D A; Chakraborty T; Goebel W; Cossart P
Molecular determinants of Listeria monocytogenes pathogenesis.
Infection and immunity 1992;60(4):1263-7.
1992: Freitag N E; Youngman P; Portnoy D A
Transcriptional activation of the Listeria monocytogenes hemolysin gene in Bacillus subtilis.
Journal of bacteriology 1992;174(4):1293-8.
1992: Portnoy D A
Innate immunity to a facultative intracellular bacterial pathogen.
Current opinion in immunology 1992;4(1):20-4.
1991: Camilli A; Goldfine H; Portnoy D A
Listeria monocytogenes mutants lacking phosphatidylinositol-specific phospholipase C are avirulent.
The Journal of experimental medicine 1991;173(3):751-4.
1990: Tilney L G; Connelly P S; Portnoy D A
Actin filament nucleation by the bacterial pathogen, Listeria monocytogenes.
The Journal of cell biology 1990;111(6 Pt 2):2979-88.
1990: Sun A N; Camilli A; Portnoy D A
Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread.
Infection and immunity 1990;58(11):3770-8.
1990: Dabiri G A; Sanger J M; Portnoy D A; Southwick F S
Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6068-72.
1990: Bielecki J; Youngman P; Connelly P; Portnoy D A
Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells.
Nature 1990;345(6271):175-6.
1989: Portnoy D A; Schreiber R D; Connelly P; Tilney L G
Gamma interferon limits access of Listeria monocytogenes to the macrophage cytoplasm.
The Journal of experimental medicine 1989;170(6):2141-6.
1989: Tilney L G; Portnoy D A
Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.
The Journal of cell biology 1989;109(4 Pt 1):1597-608.
1989: Camilli A; Paynton C R; Portnoy D A
Intracellular methicillin selection of Listeria monocytogenes mutants unable to replicate in a macrophage cell line.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5522-6.

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