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Carolyn Bertozzi

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M Sloan Siegrist; Sarah Whiteside; Arjun Aditham; Felipe Cava; John C Jewett; Carolyn R Bertozzi
(D)-amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen.
Genevieve C Van de Bittner; Carolyn R Bertozzi; Christopher J Chang
Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation.
Paresh Agarwal; David Rabuka; Ellen M Sletten; Joep van der Weijden; Carolyn R Bertozzi
A Pictet-Spengler ligation for protein chemical modification.

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All Publications

2013: M Sloan Siegrist; Sarah Whiteside; Arjun Aditham; Felipe Cava; John C Jewett; Carolyn R Bertozzi
(D)-amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen.
ACS chemical biology 2013;8(3):500-5.
2013: Genevieve C Van de Bittner; Carolyn R Bertozzi; Christopher J Chang
Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation.
Journal of the American Chemical Society 2013;135(5):1783-95.
2013: Paresh Agarwal; David Rabuka; Ellen M Sletten; Joep van der Weijden; Carolyn R Bertozzi
A Pictet-Spengler ligation for protein chemical modification.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):46-51.
2012: Amy H Henkin; Melissa Kazantzis; Gennady F Nikitin; Hyo Min Park; Mathieu G Auzias; Carolyn R Bertozzi; Allison S Cohen; Elena A Dubikovskaya; Andreas Stahl
Real-time noninvasive imaging of fatty acid uptake in vivo.
ACS chemical biology 2012;7(11):1884-91.
2012: Peyton Shieh; Matthew J Hangauer; Carolyn R Bertozzi
Fluorogenic azidofluoresceins for biological imaging.
Journal of the American Chemical Society 2012;134(42):17428-31.
2012: Benjamin M Swarts; Marina Alber; Douglas M Fox; Cynthia M Holsclaw; John C Jewett; Rainer Kalscheuer; Julie A Leary; M Sloan Siegrist; Carolyn R Bertozzi
Probing the mycobacterial trehalome with bioorthogonal chemistry.
Journal of the American Chemical Society 2012;134(39):16123-6.
2012: Kamil Godula; Carolyn R Bertozzi
Density variant glycan microarray for evaluating cross-linking of mucin-like glycoconjugates by lectins.
Journal of the American Chemical Society 2012;134(38):15732-42.
2012: Pamela V Chang; Carolyn R Bertozzi
Imaging beyond the proteome.
Chemical communications (Cambridge, England) 2012;48(71):8864-79.
2012: Seong-Ho Shin; Babak Sanii; Carolyn R Bertozzi; Sungwook Chung; Luis R Comolli; James J De Yoreo
Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(32):12968-73.
2012: Brian Belardi; Jay T Groves; Geoff P O'Donoghue; Adam W Smith; Carolyn R Bertozzi
Investigating cell surface galectin-mediated cross-linking on glycoengineered cells.
Journal of the American Chemical Society 2012;134(23):9549-52.
2012: Chelsea G Gordon; Kendall N Houk; John C Jewett; Joel L Mackey; Ellen M Sletten; Carolyn R Bertozzi
Reactivity of biarylazacyclooctynones in copper-free click chemistry.
Journal of the American Chemical Society 2012;134(22):9199-208.
2012: David Rabuka; Jason S Rush; Peng Wu; Gregory W deHart; Carolyn R Bertozzi
Site-specific chemical protein conjugation using genetically encoded aldehyde tags.
Nature protocols 2012;7(6):1052-67.
2012: Mark A Breidenbach; Krishnan K Palaniappan; Austin A Pitcher; Carolyn R Bertozzi
Mapping yeast N-glycosites with isotopically recoded glycans.
Molecular & cellular proteomics : MCP 2012;11(6):M111.015339.
2012: Hiroaki Onoe; Carolyn R Bertozzi; Erik S Douglas; Matt B Francis; Zev J Gartner; Sonny C Hsiao; Richard A Mathies
Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences.
Langmuir : the ACS journal of surfaces and colloids 2012;28(21):8120-6.
2012: Sarah A Gilmore; Cynthia M Holsclaw; Madhulika Jain; Julie A Leary; Clifton D Leigh; Michael W Schelle; Jeffery S Cox; Carolyn R Bertozzi
Sulfolipid-1 biosynthesis restricts Mycobacterium tuberculosis growth in human macrophages.
ACS chemical biology 2012;7(5):863-70.
2012: Jason E Hudak; Eva Nogales; Robyn M Barfield; Carolyn R Bertozzi; Gregory W de Hart; Patricia Grob; David Rabuka
Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag.
Angewandte Chemie (International ed. in English) 2012;51(17):4161-5.
2012: Hyun Joo An; Carolyn R Bertozzi; Phung Gip; Jaehan Kim; Cheryl T McVaugh; Kun Wook Park; David V Schaffer; Shuai Wu; Carlito B Lebrilla
Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells.
Molecular & cellular proteomics : MCP 2012;11(4):M111.010660.
2012: Seok-Ho Yu; Amberlyn M Wands; Carolyn R Bertozzi; Michelle R Bond; Michael Boyce; Jennifer J Kohler
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(13):4834-9.
2012: Jessica C Seeliger; Sarah E Tully; Zsofia Botyanszki; Benjamin F Cravatt; Sarah A Gilmore; Cynthia M Holsclaw; Julie A Leary; Michael Niederweis; Michael W Schelle; Carolyn R Bertozzi
Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
The Journal of biological chemistry 2012;287(11):7990-8000.
2012: Gabriela de Almeida; Hitomi Nakamura; Krishnan K Palaniappan; Ellen M Sletten; Carolyn R Bertozzi
Thiacycloalkynes for copper-free click chemistry.
Angewandte Chemie (International ed. in English) 2012;51(10):2443-7.
2012: Jennifer Z Yao; Chayasith Uttamapinant; Jeremy M Baskin; Carolyn R Bertozzi; Julian A Codelli; Andrei Poloukhtine; Vladimir V Popik; Ellen M Sletten; Alice Y Ting
Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition.
Journal of the American Chemical Society 2012;134(8):3720-8.
2012: Jennifer E Griffin; John D McKinney; Valerie Mizrahi; Amit K Pandey; Carolyn R Bertozzi; Sarah A Gilmore; Christopher M Sassetti
Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations.
Chemistry & biology 2012;19(2):218-27.
2012: Karen W Dehnert; Scott T Laughlin; Natasha N Naidu; Sharon L Amacher; Jeremy M Baskin; Brendan J Beahm; Carolyn R Bertozzi
Imaging the sialome during zebrafish development with copper-free click chemistry.
Chembiochem : a European journal of chemical biology 2012;13(3):353-7.
2012: Jessica C Seeliger; Kimberly M Sogi; Shana Topp; Justin P Gallivan; Mary L Previti; Carolyn R Bertozzi
A riboswitch-based inducible gene expression system for mycobacteria.
PloS one 2012;7(1):e29266.
2011: John C Jewett; Carolyn R Bertozzi
Synthesis of a fluorogenic cyclooctyne activated by Cu-free click chemistry.
Organic letters 2011;13(22):5937-9.
2011: Ellen M Sletten; Carolyn R Bertozzi
A bioorthogonal quadricyclane ligation.
Journal of the American Chemical Society 2011;133(44):17570-3.
2011: Jason E Hudak; Helen H Yu; Carolyn R Bertozzi
Protein glycoengineering enabled by the versatile synthesis of aminooxy glycans and the genetically encoded aldehyde tag.
Journal of the American Chemical Society 2011;133(40):16127-35.
2011: Carolyn R Bertozzi
A decade of bioorthogonal chemistry.
Accounts of chemical research 2011;44(9):651-3.
2011: Ellen M Sletten; Carolyn R Bertozzi
From mechanism to mouse: a tale of two bioorthogonal reactions.
Accounts of chemical research 2011;44(9):666-76.
2011: Sarah C Hubbard; Cheryl T McVaugh; Donna M Peehl; Michael Boyce; Carolyn R Bertozzi
Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells.
Bioorganic & medicinal chemistry letters 2011;21(17):4945-50.
2011: Stavroula K Hatzios; Cynthia M Holsclaw; Gerald L Newton; Michael W Schelle; Kimberly M Sogi; Robert C Fahey; Carolyn R Bertozzi
The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth.
Bioorganic & medicinal chemistry letters 2011;21(17):4956-9.
2011: Krishnan K Palaniappan; Austin A Pitcher; Brian P Smart; David R Spiciarich; Anthony T Iavarone; Carolyn R Bertozzi
Isotopic signature transfer and mass pattern prediction (IsoStamp): an enabling technique for chemically-directed proteomics.
ACS chemical biology 2011;6(8):829-36.
2011: Michael Boyce; Carolyn R Bertozzi
Bringing chemistry to life.
Nature methods 2011;8(8):638-42.
2011: Stavroula K Hatzios; Carolyn R Bertozzi
The regulation of sulfur metabolism in Mycobacterium tuberculosis.
PLoS pathogens 2011;7(7):e1002036.
2011: Karen W Dehnert; Thinh T Huynh; Scott T Laughlin; Wei Wang; Peng Wu; Sharon L Amacher; Jeremy M Baskin; Brendan J Beahm; Carolyn R Bertozzi
Metabolic labeling of fucosylated glycans in developing zebrafish.
ACS chemical biology 2011;6(6):547-52.
2011: Michael Boyce; Isaac S Carrico; Anjali S Ganguli; Seok-Ho Yu; Matthew J Hangauer; Sarah C Hubbard; Jennifer Kohler; Carolyn R Bertozzi
Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3141-6.
2011: Olivier Binda; Michael Boyce; Jason S Rush; Krishnan K Palaniappan; Carolyn R Bertozzi; Or Gozani
A chemical method for labeling lysine methyltransferase substrates.
Chembiochem : a European journal of chemical biology 2011;12(2):330-4.
2011: Wenqing Shui; Christopher J Petzold; Alyssa Redding; Jun Liu; Austin Pitcher; Leslie Sheu; Tsung-Yen Hsieh; Jay D Keasling; Carolyn R Bertozzi
Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation.
Journal of proteome research 2011;10(1):339-48.
2010: Genevieve C Van de Bittner; Elena A Dubikovskaya; Carolyn R Bertozzi; Christopher J Chang
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21316-21.
2010: Shana Topp; Colleen M K Reynoso; Jessica C Seeliger; Ian S Goldlust; Shawn K Desai; Dorothée Murat; Aimee Shen; Aaron W Puri; Arash Komeili; Carolyn R Bertozzi; June R Scott; Justin P Gallivan
Synthetic riboswitches that induce gene expression in diverse bacterial species.
Applied and environmental microbiology 2010;76(23):7881-4.
2010: Jason S Rush; Kimberly E Beatty; Carolyn R Bertozzi
Bioluminescent probes of sulfatase activity.
Chembiochem : a European journal of chemical biology 2010;11(15):2096-9.
2010: Kimberly E Beatty; John D Fisk; Brian P Smart; Ying Ying Lu; Janek Szychowski; Matthew J Hangauer; Jeremy M Baskin; Carolyn R Bertozzi; David A Tirrell
Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition.
Chembiochem : a European journal of chemical biology 2010;11(15):2092-5.
2010: Sungwook Chung; Seong-Ho Shin; Carolyn R Bertozzi; James J De Yoreo
Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(38):16536-41.
2010: Ellen M Sletten; Hitomi Nakamura; John C Jewett; Carolyn R Bertozzi
Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin.
Journal of the American Chemical Society 2010;132(33):11799-805.
2010: Kamil Godula; Carolyn R Bertozzi
Synthesis of glycopolymers for microarray applications via ligation of reducing sugars to a poly(acryloyl hydrazide) scaffold.
Journal of the American Chemical Society 2010;132(29):9963-5.
2010: Pamela V Chang; Danielle H Dube; Ellen M Sletten; Carolyn R Bertozzi
A strategy for the selective imaging of glycans using caged metabolic precursors.
Journal of the American Chemical Society 2010;132(28):9516-8.
2010: Romina P Muiá; Hai Yu; Jennifer A Prescher; Ulf Hellman; Xi Chen; Carolyn R Bertozzi; Oscar Campetella
Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation.
Glycobiology 2010;20(7):833-42.
2010: Allison S Cohen; Elena A Dubikovskaya; Jason S Rush; Carolyn R Bertozzi
Real-time bioluminescence imaging of glycans on live cells.
Journal of the American Chemical Society 2010;132(25):8563-5.
2010: Jeremy M Baskin; Karen W Dehnert; Scott T Laughlin; Sharon L Amacher; Carolyn R Bertozzi
Visualizing enveloping layer glycans during zebrafish early embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10360-5.
2010: Megan C Yap; Morris Kostiuk; Dale Martin; Maneka A Perinpanayagam; Pieter G Hak; Anjaiah Siddam; Janaki R Majjigapu; Gurram Rajaiah; Bernd Keller; Jennifer A Prescher; Peng Wu; Carolyn R Bertozzi; John R Falck; Luc G Berthiaume
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry.
Journal of lipid research 2010;51(6):1566-80.
2010: John C Jewett; Carolyn R Bertozzi
Cu-free click cycloaddition reactions in chemical biology.
Chemical Society reviews 2010;39(4):1272-9.
2010: John C Jewett; Ellen M Sletten; Carolyn R Bertozzi
Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.
Journal of the American Chemical Society 2010;132(11):3688-90.
2010: Mark A Breidenbach; Jennifer E G Gallagher; David S King; Brian P Smart; Peng Wu; Carolyn R Bertozzi
Targeted metabolic labeling of yeast N-glycans with unnatural sugars.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):3988-93.
2010: Pamela V Chang; Jennifer A Prescher; Ellen M Sletten; Jeremy M Baskin; Isaac A Miller; Nicholas J Agard; Anderson Lo; Carolyn R Bertozzi
Copper-free click chemistry in living animals.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):1821-6.
2009: Scott T Laughlin; Carolyn R Bertozzi
In vivo imaging of Caenorhabditis elegans glycans.
ACS chemical biology 2009;4(12):1068-72.
2009: Ajit Varki; Richard D Cummings; Jeffrey D Esko; Hudson H Freeze; Pamela Stanley; Jamey D Marth; Carolyn R Bertozzi; Gerald W Hart; Marilynn E Etzler
Symbol nomenclature for glycan representation.
Proteomics 2009;9(24):5398-9.
2009: Yinjie J Tang; Wenqing Shui; Samuel Myers; Xueyang Feng; Carolyn R Bertozzi; Jay D Keasling
Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis.
Biotechnology letters 2009;31(8):1233-40.
2009: Kamil Godula; Marissa L Umbel; David Rabuka; Zsofia Botyanszki; Carolyn R Bertozzi; Raghuveer Parthasarathy
Control of the molecular orientation of membrane-anchored biomimetic glycopolymers.
Journal of the American Chemical Society 2009;131(29):10263-8.
2009: Cynthia L Perrine; Anjali Ganguli; Peng Wu; Carolyn R Bertozzi; Timothy A Fritz; Jayalakshmi Raman; Lawrence Tabak; Thomas A Gerken
Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2.
The Journal of biological chemistry 2009;284(30):20387-97.
2009: Penelope M Drake; Christina M Stock; Jay K Nathan; Phung Gip; Kevin P K Golden; Birgit Weinhold; Rita Gerardy-Schahn; Carolyn R Bertozzi
Polysialic acid governs T-cell development by regulating progenitor access to the thymus.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):11995-2000.
2009: Erik S Douglas; Sonny C Hsiao; Hiroaki Onoe; Carolyn R Bertozzi; Matt B Francis; Richard A Mathies
DNA-barcode directed capture and electrochemical metabolic analysis of single mammalian cells on a microelectrode array.
Lab on a chip 2009;9(14):2010-5.
2009: Merel A Nessen; Gertjan Kramer; JaapWillem Back; Jeremy M Baskin; Linde E J Smeenk; Leo J de Koning; Jan H van Maarseveen; Luitzen de Jong; Carolyn R Bertozzi; Henk Hiemstra; Chris G de Koster
Selective enrichment of azide-containing peptides from complex mixtures.
Journal of proteome research 2009;8(7):3702-11.
2009: Sonny C Hsiao; Betty J Shum; Hiroaki Onoe; Erik S Douglas; Zev J Gartner; Richard A Mathies; Carolyn R Bertozzi; Matthew B Francis
Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns.
Langmuir : the ACS journal of surfaces and colloids 2009;25(12):6985-91.
2009: Nicholas J Agard; Carolyn R Bertozzi
Chemical approaches to perturb, profile, and perceive glycans.
Accounts of chemical research 2009;42(6):788-97.
2009: Jie Song; Jianwen Xu; Tera Filion; Eduardo Saiz; Antoni P Tomsia; Jane B Lian; Gary S Stein; David C Ayers; Carolyn R Bertozzi
Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications.
Journal of biomedical materials research. Part A 2009;89(4):1098-107.
2009: Stavroula K Hatzios; Michael W Schelle; Cynthia M Holsclaw; Christopher R Behrens; Zsofia Botyanszki; Fiona L Lin; Brian L Carlson; Pawan Kumar; Julie A Leary; Carolyn R Bertozzi
PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.
The Journal of biological chemistry 2009;284(19):12745-51.
2009: Christopher W Harland; Zsofia Botyanszki; David Rabuka; Carolyn R Bertozzi; Raghuveer Parthasarathy
Synthetic trehalose glycolipids confer desiccation resistance to supported lipid monolayers.
Langmuir : the ACS journal of surfaces and colloids 2009;25(9):5193-8.
2009: Gene H Hur; Jordan L Meier; Jeremy Baskin; Julian A Codelli; Carolyn R Bertozzi; Mohamed A Marahiel; Michael D Burkart
Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis.
Chemistry & biology 2009;16(4):372-81.
2009: Adam W Barb; Tanya M Leavy; Lori I Robins; Ziqiang Guan; David A Six; Pei Zhou; Matthew J Hangauer; Carolyn R Bertozzi; Christian R H Raetz
Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC.
Biochemistry 2009;48(14):3068-77.
2009: Zev J Gartner; Carolyn R Bertozzi
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4606-10.
2009: Peng Wu; Wenqing Shui; Brian L Carlson; Nancy Hu; David Rabuka; Julia Lee; Carolyn R Bertozzi
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3000-5.
2009: Xing Chen; Peng Wu; Michael Rousseas; David Okawa; Zev Gartner; Alex Zettl; Carolyn R Bertozzi
Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells.
Journal of the American Chemical Society 2009;131(3):890-1.
2009: Scott T Laughlin; Carolyn R Bertozzi
Imaging the glycome.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):12-7.
2009: Ellen M Sletten; Carolyn R Bertozzi
Bioorthogonal chemistry: fishing for selectivity in a sea of functionality.
Angewandte Chemie (International ed. in English) 2009;48(38):6974-98.
2009: Kamil Godula; David Rabuka; Ki Tae Nam; Carolyn R Bertozzi
Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications.
Angewandte Chemie (International ed. in English) 2009;48(27):4973-6.
2009: Pamela V Chang; Xing Chen; Chris Smyrniotis; Alexander Xenakis; Tianshun Hu; Carolyn R Bertozzi; Peng Wu
Metabolic labeling of sialic acids in living animals with alkynyl sugars.
Angewandte Chemie (International ed. in English) 2009;48(22):4030-3.
2009: Wenqing Shui; Sarah A Gilmore; Leslie Sheu; Jun Liu; Jay D Keasling; Carolyn R Bertozzi
Quantitative proteomic profiling of host-pathogen interactions: the macrophage response to Mycobacterium tuberculosis lipids.
Journal of proteome research 2009;8(1):282-9.
2008: Ramesh Jasti; Joydeep Bhattacharjee; Jeffrey B Neaton; Carolyn R Bertozzi
Synthesis, characterization, and theory of [9]-, [12]-, and [18]cycloparaphenylene: carbon nanohoop structures.
Journal of the American Chemical Society 2008;130(52):17646-7.
2008: Nicholas M Toriello; Erik S Douglas; Numrin Thaitrong; Sonny C Hsiao; Matthew B Francis; Carolyn R Bertozzi; Richard A Mathies
Integrated microfluidic bioprocessor for single-cell gene expression analysis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20173-8.
2008: Penelope M Drake; Jay K Nathan; Christina M Stock; Pamela V Chang; Marcus O Muench; Daisuke Nakata; J Rachel Reader; Phung Gip; Kevin P K Golden; Birgit Weinhold; Rita Gerardy-Schahn; Frederic A Troy; Carolyn R Bertozzi
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6850-8.
2008: Wenqing Shui; Leslie Sheu; Jun Liu; Brian Smart; Christopher J Petzold; Tsung-Yen Hsieh; Austin Pitcher; Jay D Keasling; Carolyn R Bertozzi
Membrane proteomics of phagosomes suggests a connection to autophagy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):16952-7.
2008: Cynthia M Holsclaw; Kimberly M Sogi; Sarah A Gilmore; Michael W Schelle; Michael D Leavell; Carolyn R Bertozzi; Julie A Leary
Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis.
ACS chemical biology 2008;3(10):619-24.
2008: Jennifer L Czlapinski; Michael W Schelle; Lawrence Miller; Scott T Laughlin; Jennifer Kohler; Virginia W Cornish; Carolyn R Bertozzi
Conditional glycosylation in eukaryotic cells using a biocompatible chemical inducer of dimerization.
Journal of the American Chemical Society 2008;130(40):13186-7.
2008: Jason S Rush; Carolyn R Bertozzi
New aldehyde tag sequences identified by screening formylglycine generating enzymes in vitro and in vivo.
Journal of the American Chemical Society 2008;130(37):12240-1.
2008: Julian A Codelli; Jeremy M Baskin; Nicholas J Agard; Carolyn R Bertozzi
Second-generation difluorinated cyclooctynes for copper-free click chemistry.
Journal of the American Chemical Society 2008;130(34):11486-93.
2008: Brian L Carlson; Edward R Ballister; Emmanuel Skordalakes; David S King; Mark A Breidenbach; Sarah A Gilmore; James M Berger; Carolyn R Bertozzi
Function and structure of a prokaryotic formylglycine-generating enzyme.
The Journal of biological chemistry 2008;283(29):20117-25.
2008: Ellen M Sletten; Carolyn R Bertozzi
A hydrophilic azacyclooctyne for Cu-free click chemistry.
Organic letters 2008;10(14):3097-9.
2008: Jeremiah A Johnson; Jeremy M Baskin; Carolyn R Bertozzi; Jeffrey T Koberstein; Nicholas J Turro
Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers.
Chemical communications (Cambridge, England) 2008;(26):3064-6.
2008: Margot G Paulick; Carolyn R Bertozzi
The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins.
Biochemistry 2008;47(27):6991-7000.
2008: Christopher W Harland; David Rabuka; Carolyn R Bertozzi; Raghuveer Parthasarathy
The Mycobacterium tuberculosis virulence factor trehalose dimycolate imparts desiccation resistance to model mycobacterial membranes.
Biophysical journal 2008;94(12):4718-24.
2008: Stavroula K Hatzios; Anthony T Iavarone; Carolyn R Bertozzi
Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase.
Biochemistry 2008;47(21):5823-31.
2008: David Rabuka; Martin Forstner; Jay T Groves; Carolyn R Bertozzi
Noncovalent cell surface engineering: incorporation of bioactive synthetic glycopolymers into cellular membranes.
Journal of the American Chemical Society 2008;130(18):5947-53.
2008: Scott T Laughlin; Jeremy M Baskin; Sharon L Amacher; Carolyn R Bertozzi
In vivo imaging of membrane-associated glycans in developing zebrafish.
Science (New York, N.Y.) 2008;320(5876):664-7.
2008: Morris Kostiuk; Maria Martha Corvi; Bernd Keller; Greg Plummer; Jennifer A Prescher; Matthew J Hangauer; Carolyn R Bertozzi; Gurram Rajaiah; John R Falck; Luc G Berthiaume
Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(3):721-32.
2008: Dale Martin; Gonzalo L Vilas; Jennifer A Prescher; Gurram Rajaiah; John R Falck; Carolyn R Bertozzi; Luc G Berthiaume
Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(3):797-806.
2008: E Tian; Kelly G Ten Hagen; Lillian Shum; Howard C Hang; Yoannis Imbert; William W Young; Carolyn R Bertozzi; Lawrence Tabak
An inhibitor of O-glycosylation induces apoptosis in NIH3T3 cells and developing mouse embryonic mandibular tissues.
The Journal of biological chemistry 2008;283(7):4460.
2008: Clifton D Leigh; Carolyn R Bertozzi
Synthetic studies toward Mycobacterium tuberculosis sulfolipid-I.
The Journal of organic chemistry 2008;73(3):1008-17.
2008: Sonny C Hsiao; Ailey K Crow; Wilbur A Lam; Carolyn R Bertozzi; Daniel A Fletcher; Matt B Francis
DNA-coated AFM cantilevers for the investigation of cell adhesion and the patterning of live cells.
Angewandte Chemie (International ed. in English) 2008;47(44):8473-7.
2008: Peng Wu; Xing Chen; Nancy Hu; Un Chong Tam; Ola Blixt; Alex Zettl; Carolyn R Bertozzi
Biocompatible carbon nanotubes generated by functionalization with glycodendrimers.
Angewandte Chemie (International ed. in English) 2008;47(27):5022-5.
2008: Matthew J Hangauer; Carolyn R Bertozzi
A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation.
Angewandte Chemie (International ed. in English) 2008;47(13):2394-7.
2007: Margot G Paulick; Martin Forstner; Jay T Groves; Carolyn R Bertozzi
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20332-7.
2007: Marta Fernández-Suárez; Hemanta Baruah; Laura Martínez-Hernández; Kathleen T Xie; Jeremy M Baskin; Carolyn R Bertozzi; Alice Y Ting
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes.
Nature biotechnology 2007;25(12):1483-7.
2007: Erik S Douglas; Ravi A Chandra; Carolyn R Bertozzi; Richard A Mathies; Matt B Francis
Self-assembled cellular microarrays patterned using DNA barcodes.
Lab on a chip 2007;7(11):1442-8.
2007: Raghuveer Parthasarathy; David Rabuka; Carolyn R Bertozzi; Jay T Groves
Molecular orientation of membrane-anchored mucin glycoprotein mimics.
The journal of physical chemistry. B 2007;111(42):12133-5.
2007: Jeremy M Baskin; Jennifer A Prescher; Scott T Laughlin; Nicholas J Agard; Pamela V Chang; Isaac A Miller; Anderson Lo; Julian A Codelli; Carolyn R Bertozzi
Copper-free click chemistry for dynamic in vivo imaging.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):16793-7.
2007: Fiona L Lin; Herman van Halbeek; Carolyn R Bertozzi
Synthesis of mono- and dideoxygenated alpha,alpha-trehalose analogs.
Carbohydrate research 2007;342(14):2014-30.
2007: Mandana Veiseh; Omid Veiseh; Michael C Martin; Carolyn R Bertozzi; Miqin Zhang
Single-cell-based sensors and synchrotron FTIR spectroscopy: a hybrid system towards bacterial detection.
Biosensors & bioelectronics 2007;23(2):253-60.
2007: Margot G Paulick; Amber R Wise; Martin Forstner; Jay T Groves; Carolyn R Bertozzi
Synthetic analogues of glycosylphosphatidylinositol-anchored proteins and their behavior in supported lipid bilayers.
Journal of the American Chemical Society 2007;129(37):11543-50.
2007: Tanya M Leavy; Carolyn R Bertozzi
A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates.
Bioorganic & medicinal chemistry letters 2007;17(14):3851-4.
2007: Pamela V Chang; Jennifer A Prescher; Matthew J Hangauer; Carolyn R Bertozzi
Imaging cell surface glycans with bioorthogonal chemical reporters.
Journal of the American Chemical Society 2007;129(27):8400-1.
2007: Pawan Kumar; Michael W Schelle; Madhulika Jain; Fiona L Lin; Christopher J Petzold; Michael D Leavell; Julie A Leary; Jeffery S Cox; Carolyn R Bertozzi
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11221-6.
2007: Isaac S Carrico; Brian L Carlson; Carolyn R Bertozzi
Introducing genetically encoded aldehydes into proteins.
Nature chemical biology 2007;3(6):321-2.
2007: Xing Chen; Andras Kis; Alex Zettl; Carolyn R Bertozzi
A cell nanoinjector based on carbon nanotubes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8218-22.
2007: David Rabuka; Raghuveer Parthasarathy; Goo Soo Lee; Xing Chen; Jay T Groves; Carolyn R Bertozzi
Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers.
Journal of the American Chemical Society 2007;129(17):5462-71.
2007: Ryan Senaratne; Joseph D Mougous; J Rachel Reader; Spencer J Williams; Tianjiao Zhang; Carolyn R Bertozzi; Lee W Riley
Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant.
Journal of medical microbiology 2007;56(Pt 4):454-8.
2007: Madhulika Jain; Christopher J Petzold; Michael W Schelle; Michael D Leavell; Joseph D Mougous; Carolyn R Bertozzi; Julie A Leary; Jeffery S Cox
Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5133-8.
2007: Hong Gao; Julie Leary; Kate S Carroll; Carolyn R Bertozzi; Huiyi Chen
Noncovalent complexes of APS reductase from M. tuberculosis: delineating a mechanistic model using ESI-FTICR MS.
Journal of the American Society for Mass Spectrometry 2007;18(2):167-78.
2007: Scott T Laughlin; Carolyn R Bertozzi
Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation.
Nature protocols 2007;2(11):2930-44.
2006: Jennifer L Czlapinski; Carolyn R Bertozzi
Synthetic glycobiology: Exploits in the Golgi compartment.
Current opinion in chemical biology 2006;10(6):645-51.
2006: John W Kehoe; Nileena Velappan; Monica Walbolt; Jytte Rasmussen; Dave King; Jianlong Lou; Kristeene Knopp; Peter Pavlik; James D Marks; Carolyn R Bertozzi; Andrew R M Bradbury
Using phage display to select antibodies recognizing post-translational modifications independently of sequence context.
Molecular & cellular proteomics : MCP 2006;5(12):2350-63.
2006: Justin Chartron; Kate S Carroll; Carrie Shiau; Hong Gao; Julie A Leary; Carolyn R Bertozzi; C David Stout
Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5'-phosphosulfate reductase.
Journal of molecular biology 2006;364(2):152-69.
2006: Nicholas J Agard; Jeremy M Baskin; Jennifer A Prescher; Anderson Lo; Carolyn R Bertozzi
A comparative study of bioorthogonal reactions with azides.
ACS chemical biology 2006;1(10):644-8.
2006: Michael W Schelle; Carolyn R Bertozzi
Sulfate metabolism in mycobacteria.
Chembiochem : a European journal of chemical biology 2006;7(10):1516-24.
2006: David Rabuka; Sarah C Hubbard; Scott T Laughlin; Sulabha P Argade; Carolyn R Bertozzi
A chemical reporter strategy to probe glycoprotein fucosylation.
Journal of the American Chemical Society 2006;128(37):12078-9.
2006: Jennifer A Prescher; Carolyn R Bertozzi
Chemical technologies for probing glycans.
Cell 2006;126(5):851-4.
2006: Cheri L Stowell; Kevin K Barvian; Peter C M Young; Robert M Bigsby; Dawn E Verdugo; Carolyn R Bertozzi; Theodore S Widlanski
A role for sulfation-desulfation in the uptake of bisphenol a into breast tumor cells.
Chemistry & biology 2006;13(8):891-7.
2006: A James Link; Monique Vink; Nicholas J Agard; Jennifer A Prescher; Carolyn R Bertozzi; David A Tirrell
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10180-5.
2006: Xing Chen; Un Chong Tam; Jennifer L Czlapinski; Goo Soo Lee; David Rabuka; Alex Zettl; Carolyn R Bertozzi
Interfacing carbon nanotubes with living cells.
Journal of the American Chemical Society 2006;128(19):6292-3.
2006: Danielle H Dube; Jennifer A Prescher; Chi N Quang; Carolyn R Bertozzi
Probing mucin-type O-linked glycosylation in living animals.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):4819-24.
2006: Joseph D Mougous; Ryan Senaratne; Christopher J Petzold; Madhulika Jain; Dong H Lee; Michael W Schelle; Michael D Leavell; Jeffery S Cox; Julie A Leary; Lee W Riley; Carolyn R Bertozzi
A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4258-63.
2006: Ryan Senaratne; A Dharshan De Silva; Spencer J Williams; Joseph D Mougous; J Rachel Reader; Tianjiao Zhang; Stephen Chan; Ben Sidders; Dong H Lee; John Chan; Carolyn R Bertozzi; Lee W Riley
5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice.
Molecular microbiology 2006;59(6):1744-53.
2006: Juan Perez-Vilar; Raean Mabolo; Cheryl T McVaugh; Carolyn R Bertozzi; Richard C Boucher
Mucin granule intraluminal organization in living mucous/goblet cells. Roles of protein post-translational modifications and secretion.
The Journal of biological chemistry 2006;281(8):4844-55.
2006: Ravi A Chandra; Erik S Douglas; Richard A Mathies; Carolyn R Bertozzi; Matt B Francis
Programmable cell adhesion encoded by DNA hybridization.
Angewandte Chemie (International ed. in English) 2006;45(6):896-901.
2006: Joseph D Mougous; Dong H Lee; Sarah C Hubbard; Michael W Schelle; David J Vocadlo; James M Berger; Carolyn R Bertozzi
Molecular basis for G protein control of the prokaryotic ATP sulfurylase.
Molecular cell 2006;21(1):109-22.
2006: Jason Rush; Carolyn R Bertozzi
An alpha-formylglycine building block for fmoc-based solid-phase peptide synthesis.
Organic letters 2006;8(1):131-4.
2006: Scott T Laughlin; Nicholas J Agard; Jeremy M Baskin; Isaac S Carrico; Pamela V Chang; Anjali S Ganguli; Matthew J Hangauer; Anderson Lo; Jennifer A Prescher; Carolyn R Bertozzi
Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics.
Methods in enzymology 2006;415():230-50.
2005: Kate S Carroll; Hong Gao; Huiyi Chen; Julie A Leary; Carolyn R Bertozzi
Investigation of the iron-sulfur cluster in Mycobacterium tuberculosis APS reductase: implications for substrate binding and catalysis.
Biochemistry 2005;44(44):14647-57.
2005: Michael J Grogan; Yoshihisa Kaizuka; Rosemary M Conrad; Jay T Groves; Carolyn R Bertozzi
Synthesis of lipidated green fluorescent protein and its incorporation in supported lipid bilayers.
Journal of the American Chemical Society 2005;127(41):14383-7.
2005: Howard C Hang; Carolyn R Bertozzi
The chemistry and biology of mucin-type O-linked glycosylation.
Bioorganic & medicinal chemistry 2005;13(17):5021-34.
2005: Kate S Carroll; Hong Gao; Huiyi Chen; C David Stout; Julie A Leary; Carolyn R Bertozzi
A conserved mechanism for sulfonucleotide reduction.
PLoS biology 2005;3(8):e250.
2005: Ola M Saad; Heiner Ebel; Kenji Uchimura; Steven D Rosen; Carolyn R Bertozzi; Julie A Leary
Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase.
Glycobiology 2005;15(8):818-26.
2005: Jennifer A Prescher; Carolyn R Bertozzi
Chemistry in living systems.
Nature chemical biology 2005;1(1):13-21.
2005: Danielle H Dube; Carolyn R Bertozzi
Glycans in cancer and inflammation--potential for therapeutics and diagnostics.
Nature reviews. Drug discovery 2005;4(6):477-88.
2005: Na Pi; Mike B Hoang; Hong Gao; Joseph D Mougous; Carolyn R Bertozzi; Julie A Leary
Kinetic measurements and mechanism determination of Stf0 sulfotransferase using mass spectrometry.
Analytical biochemistry 2005;341(1):94-104.
2005: Jie Song; Viengkham Malathong; Carolyn R Bertozzi
Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone.
Journal of the American Chemical Society 2005;127(10):3366-72.
2005: Fiona L Lin; Helen M Hoyt; Herman van Halbeek; Robert G Bergman; Carolyn R Bertozzi
Mechanistic investigation of the staudinger ligation.
Journal of the American Chemical Society 2005;127(8):2686-95.
2005: Matthew R. Pratt; Carolyn R Bertozzi
Synthetic glycopeptides and glycoproteins as tools for biology.
Chemical Society reviews 2005;34(1):58-68.
2004: Sarah J Luchansky; Carolyn R Bertozzi
Azido sialic acids can modulate cell-surface interactions.
Chembiochem : a European journal of chemical biology 2004;5(12):1706-9.
2004: Christopher L De Graffenried; Scott T Laughlin; Jennifer Kohler; Carolyn R Bertozzi
A small-molecule switch for Golgi sulfotransferases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16715-20.
2004: E Tian; Kelly G Ten Hagen; Lillian Shum; Howard C Hang; Yoannis Imbert; William W Young; Carolyn R Bertozzi; Lawrence Tabak
An inhibitor of O-glycosylation induces apoptosis in NIH3T3 cells and developing mouse embryonic mandibular tissues.
The Journal of biological chemistry 2004;279(48):50382-90.
2004: Nicholas J Agard; Jennifer A Prescher; Carolyn R Bertozzi
A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems.
Journal of the American Chemical Society 2004;126(46):15046-7.
2004: Xing Chen; Goo Soo Lee; Alex Zettl; Carolyn R Bertozzi
Biomimetic engineering of carbon nanotubes by using cell surface mucin mimics.
Angewandte Chemie (International ed. in English) 2004;43(45):6111-6.
2004: Catherine M Klapperich; Carolyn R Bertozzi
Global gene expression of cells attached to a tissue engineering scaffold.
Biomaterials 2004;25(25):5631-41.
2004: David J Vocadlo; Carolyn R Bertozzi
A strategy for functional proteomic analysis of glycosidase activity from cell lysates.
Angewandte Chemie (International ed. in English) 2004;43(40):5338-42.
2004: Jennifer Kohler; Jennifer L Czlapinski; Scott T Laughlin; Michael W Schelle; Christopher L De Graffenried; Carolyn R Bertozzi
Directing flux in glycan biosynthetic pathways with a small molecule switch.
Chembiochem : a European journal of chemical biology 2004;5(10):1455-8.
2004: Sarah J Luchansky; Sulabha P Argade; Bradley K Hayes; Carolyn R Bertozzi
Metabolic functionalization of recombinant glycoproteins.
Biochemistry 2004;43(38):12358-66.
2004: Christopher L De Graffenried; Carolyn R Bertozzi
The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity.
The Journal of biological chemistry 2004;279(38):40035-43.
2004: Jennifer A Prescher; Danielle H Dube; Carolyn R Bertozzi
Chemical remodelling of cell surfaces in living animals.
Nature 2004;430(7002):873-7.
2004: Christopher L De Graffenried; Carolyn R Bertozzi
The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus.
Current opinion in cell biology 2004;16(4):356-63.
2004: Joseph D Mougous; Christopher J Petzold; Ryan Senaratne; Dong H Lee; David L Akey; Fiona L Lin; Sarah E Munchel; Matthew R. Pratt; Lee W Riley; Julie A Leary; James M Berger; Carolyn R Bertozzi
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis.
Nature structural & molecular biology 2004;11(8):721-9.
2004: Jie Song; justin cisar; Carolyn R Bertozzi
Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds.
Journal of the American Chemical Society 2004;126(27):8459-65.
2004: Peter J Woodruff; Brian L Carlson; Bunpote Siridechadilok; Matthew R. Pratt; Ryan Senaratne; Joseph D Mougous; Lee W Riley; Spencer J Williams; Carolyn R Bertozzi
Trehalose is required for growth of Mycobacterium smegmatis.
The Journal of biological chemistry 2004;279(28):28835-43.
2004: Matthew R. Pratt; Carolyn R Bertozzi
Syntheses of 6-sulfo sialyl Lewis X glycans corresponding to the L-selectin ligand "sulfoadhesin".
Organic letters 2004;6(14):2345-8.
2004: Matthew R. Pratt; Howard C Hang; Kelly G Ten Hagen; Jason Rarick; Thomas A Gerken; Lawrence Tabak; Carolyn R Bertozzi
Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling.
Chemistry & biology 2004;11(7):1009-16.
2004: Derek Macmillan; Carolyn R Bertozzi
Modular assembly of glycoproteins: towards the synthesis of GlyCAM-1 by using expressed protein ligation.
Angewandte Chemie (International ed. in English) 2004;43(11):1355-9.
2004: Sarah J Luchansky; Scarlett Goon; Carolyn R Bertozzi
Expanding the diversity of unnatural cell-surface sialic acids.
Chembiochem : a European journal of chemical biology 2004;5(3):371-4.
2004: Howard C Hang; Chong Yu; Kelly G Ten Hagen; E Tian; Katharine A Winans; Lawrence Tabak; Carolyn R Bertozzi
Small molecule inhibitors of mucin-type O-linked glycosylation from a uridine-based library.
Chemistry & biology 2004;11(3):337-45.
2004: Howard C Hang; Chong Yu; Matthew R. Pratt; Carolyn R Bertozzi
Probing glycosyltransferase activities with the Staudinger ligation.
Journal of the American Chemical Society 2004;126(1):6-7.
2004: HL Grossman; W R Myers; V J Vreeland; R Bruehl; M D Alper; Carolyn R Bertozzi; John Clarke
Detection of bacteria in suspension by using a superconducting quantum interference device.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):129-34.
2003: Howard C Hang; Chong Yu; Darryl L Kato; Carolyn R Bertozzi
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14846-51.
2003: Jennifer Kohler; Carolyn R Bertozzi
Regulating cell surface glycosylation by small molecule control of enzyme localization.
Chemistry & biology 2003;10(12):1303-11.
2003: Christopher L De Graffenried; Carolyn R Bertozzi
Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.
The Journal of biological chemistry 2003;278(41):40282-95.
2003: Danielle H Dube; Carolyn R Bertozzi
Metabolic oligosaccharide engineering as a tool for glycobiology.
Current opinion in chemical biology 2003;7(5):616-25.
2003: Boguslaw S Wojczyk; Magdalena M Stwora-Wojczyk; Fred K Hagen; Boris Striepen; Howard C Hang; Carolyn R Bertozzi; David S Roos; Steven L Spitalnik
cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii.
Molecular and biochemical parasitology 2003;131(2):93-107.
2003: Matthew R. Pratt; Clifton D Leigh; Carolyn R Bertozzi
Formation of 1,1-alpha,alpha-glycosidic bonds by intramolecular aglycone delivery. A convergent synthesis of trehalose.
Organic letters 2003;5(18):3185-8.
2003: David J Vocadlo; Howard C Hang; Eun-Ju Kim; John Hanover; Carolyn R Bertozzi
A chemical approach for identifying O-GlcNAc-modified proteins in cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9116-21.
2003: Matthew R. Pratt; Carolyn R Bertozzi
Chemoselective ligation applied to the synthesis of a biantennary N-linked glycoform of CD52.
Journal of the American Chemical Society 2003;125(20):6149-59.
2003: Scott E Converse; Joseph D Mougous; Michael D Leavell; Julie A Leary; Carolyn R Bertozzi; Jeffery S Cox
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6121-6.
2003: George A Lemieux; Christopher L De Graffenried; Carolyn R Bertozzi
A fluorogenic dye activated by the staudinger ligation.
Journal of the American Chemical Society 2003;125(16):4708-9.
2003: Scarlett Goon; Birgit Schilling; Michael V Tullius; Bradford W Gibson; Carolyn R Bertozzi
Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3089-94.
2003: Sarah J Luchansky; Kevin J Yarema; Saori Takahashi; Carolyn R Bertozzi
GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism.
The Journal of biological chemistry 2003;278(10):8035-42.
2003: Lisa A Marcaurelle; Matthew R. Pratt; Carolyn R Bertozzi
Synthesis of thioether-linked analogues of the 2,3-sialyl-TF and MECA-79 antigens: mucin-type glycopeptides associated with cancer and inflammation.
Chembiochem : a European journal of chemical biology 2003;4(2-3):224-8.
2003: Jie Song; Eduardo Saiz; Carolyn R Bertozzi
A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites.
Journal of the American Chemical Society 2003;125(5):1236-43.
2003: Joshua I Armstrong; Dawn E Verdugo; Carolyn R Bertozzi
Synthesis of a bisubstrate analogue targeting estrogen sulfotransferase.
The Journal of organic chemistry 2003;68(1):170-3.
2003: Sarah J Luchansky; Howard C Hang; Eliana Saxon; Jocelyn R Grunwell; Chong Yu; Danielle H Dube; Carolyn R Bertozzi
Constructing azide-labeled cell surfaces using polysaccharide biosynthetic pathways.
Methods in enzymology 2003;362():249-72.
2003: Michael S Scherman; Katharine A Winans; Richard J Stern; Victoria Jones; Carolyn R Bertozzi; Michael R McNeil
Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library.
Antimicrobial agents and chemotherapy 2003;47(1):378-82.
2002: Jocelyn R Grunwell; Virginia L Rath; Jytte Rasmussen; Zeljka Cabrilo; Carolyn R Bertozzi
Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases.
Biochemistry 2002;41(52):15590-600.
2002: Joseph D Mougous; Michael D Leavell; Ryan Senaratne; Clifton D Leigh; Spencer J Williams; Lee W Riley; Julie A Leary; Carolyn R Bertozzi
Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17037-42.
2002: Eliana Saxon; Sarah J Luchansky; Howard C Hang; Chong Yu; Sandy C Lee; Carolyn R Bertozzi
Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation.
Journal of the American Chemical Society 2002;124(50):14893-902.
2002: Na Pi; Joshua I Armstrong; Carolyn R Bertozzi; Julie A Leary
Kinetic analysis of NodST sulfotransferase using an electrospray ionization mass spectrometry assay.
Biochemistry 2002;41(44):13283-8.
2002: Jocelyn R Grunwell; Carolyn R Bertozzi
Carbohydrate sulfotransferases of the GalNAc/Gal/GlcNAc6ST family.
Biochemistry 2002;41(44):13117-26.
2002: Spencer J Williams; Ryan Senaratne; Joseph D Mougous; Lee W Riley; Carolyn R Bertozzi
5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria.
The Journal of biological chemistry 2002;277(36):32606-15.
2002: Dawn E Verdugo; Carolyn R Bertozzi
A 96-well dot-blot assay for carbohydrate sulfotransferases.
Analytical biochemistry 2002;307(2):330-6.
2002: Joseph D Mougous; Richard E Green; Spencer J Williams; Steven E Brenner; Carolyn R Bertozzi
Sulfotransferases and sulfatases in mycobacteria.
Chemistry & biology 2002;9(7):767-76.
2002: Lisa A Marcaurelle; Carolyn R Bertozzi
Recent advances in the chemical synthesis of mucin-like glycoproteins.
Glycobiology 2002;12(6):69R-77R.
2002: Rosemary M Conrad; Michael J Grogan; Carolyn R Bertozzi
Stereoselective synthesis of myo-inositol via ring-closing metathesis: a building block for glycosylphosphatidylinositol (GPI) anchor synthesis.
Organic letters 2002;4(8):1359-61.
2002: Brian N Cook; Carolyn R Bertozzi
Chemical approaches to the investigation of cellular systems.
Bioorganic & medicinal chemistry 2002;10(4):829-40.
2002: Neil W Charter; Lara K Mahal; Daniel E Koshland; Carolyn R Bertozzi
Differential effects of unnatural sialic acids on the polysialylation of the neural cell adhesion molecule and neuronal behavior.
The Journal of biological chemistry 2002;277(11):9255-61.
2002: John W Kehoe; Dustin J Maly; Dawn E Verdugo; Joshua I Armstrong; Brian N Cook; Ying-Bin Ouyang; Kevin L Moore; Jonathan A Ellman; Carolyn R Bertozzi
Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly.
Bioorganic & medicinal chemistry letters 2002;12(3):329-32.
2002: Kristi L Kiick; Eliana Saxon; David A Tirrell; Carolyn R Bertozzi
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):19-24.
2002: Michael J Grogan; Matthew R. Pratt; Lisa A Marcaurelle; Carolyn R Bertozzi
Homogeneous glycopeptides and glycoproteins for biological investigation.
Annual review of biochemistry 2002;71():593-634.
2002: Katharine A Winans; Carolyn R Bertozzi
An inhibitor of the human UDP-GlcNAc 4-epimerase identified from a uridine-based library: a strategy to inhibit O-linked glycosylation.
Chemistry & biology 2002;9(1):113-29.
2001: D A Nauman; Carolyn R Bertozzi
Kinetic parameters for small-molecule drug delivery by covalent cell surface targeting.
Biochimica et biophysica acta 2001;1568(2):147-54.
2001: Lisa A Marcaurelle; Y Shin; Scarlett Goon; Carolyn R Bertozzi
Synthesis of oxime-linked mucin mimics containing the tumor-related T(N) and sialyl T(N) antigens.
Organic letters 2001;3(23):3691-4.
2001: nicole Sampson; M Mrksich; Carolyn R Bertozzi
Surface molecular recognition.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):12870-1.
2001: C L Jacobs; Scarlett Goon; Kevin J Yarema; Stephan Hinderlich; Howard C Hang; D H Chai; Carolyn R Bertozzi
Substrate specificity of the sialic acid biosynthetic pathway.
Biochemistry 2001;40(43):12864-74.
2001: Birgit Schilling; S Goon; Nicole M Samuels; Sara P Gaucher; Julie A Leary; Carolyn R Bertozzi; Bradford W Gibson
Biosynthesis of sialylated lipooligosaccharides in Haemophilus ducreyi is dependent on exogenous sialic acid and not mannosamine. Incorporation studies using N-acylmannosamine analogues, N-glycolylneuraminic acid, and 13C-labeled N-acetylneuraminic acid.
Biochemistry 2001;40(42):12666-77.
2001: Lara K Mahal; Neil W Charter; K Angata; M Fukuda; Daniel E Koshland; Carolyn R Bertozzi
A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells.
Science (New York, N.Y.) 2001;294(5541):380-1.
2001: Veronica De Sanctis; Carolyn R Bertozzi; Giovanna Costanzo; Ernesto Di Mauro; Rodolfo Negri
Cell cycle arrest determines the intensity of the global transcriptional response of Saccharomyces cerevisiae to ionizing radiation.
Radiation research 2001;156(4):379-87.
2001: Howard C Hang; Carolyn R Bertozzi
Chemoselective approaches to glycoprotein assembly.
Accounts of chemical research 2001;34(9):727-36.
2001: Joshua I Armstrong; X Ge; Dawn E Verdugo; Katharine A Winans; Julie A Leary; Carolyn R Bertozzi
A library approach to the generation of bisubstrate analogue sulfotransferase inhibitors.
Organic letters 2001;3(17):2657-60.
2001: Dawn E Verdugo; MT Cancilla; X Ge; Nathanael S Gray; Young-Tae Chang; Peter G Schultz; M Negishi; Julie A Leary; Carolyn R Bertozzi
Discovery of estrogen sulfotransferase inhibitors from a purine library screen.
Journal of medicinal chemistry 2001;44(17):2683-6.
2001: Kevin J Yarema; Scarlett Goon; Carolyn R Bertozzi
Metabolic selection of glycosylation defects in human cells.
Nature biotechnology 2001;19(6):553-8.
2001: RE Bruehl; F Dasgupta; Tamiko R Katsumoto; J H Tan; Carolyn R Bertozzi; Wayne R Spevak; D J Ahn; Steven D Rosen; J O Nagy
Polymerized liposome assemblies: bifunctional macromolecular selectin inhibitors mimicking physiological selectin ligands.
Biochemistry 2001;40(20):5964-74.
2001: KG Bowman; Brian N Cook; Christopher L De Graffenried; Carolyn R Bertozzi
Biosynthesis of L-selectin ligands: sulfation of sialyl Lewis x-related oligosaccharides by a family of GlcNAc-6-sulfotransferases.
Biochemistry 2001;40(18):5382-91.
2001: Carolyn R Bertozzi; L L Kiessling
Chemical glycobiology.
Science (New York, N.Y.) 2001;291(5512):2357-64.
2001: Lisa A Marcaurelle; LS Mizoue; Jill Wilken; L Oldham; Stephen B H Kent; Tracy M Handel; Carolyn R Bertozzi
Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(5):1129-32.
2001: George A Lemieux; Carolyn R Bertozzi
Modulating cell surface immunoreactivity by metabolic induction of unnatural carbohydrate antigens.
Chemistry & biology 2001;8(3):265-75.
2001: Lisa A Marcaurelle; Carolyn R Bertozzi
Chemoselective elaboration of O-linked glycopeptide mimetics by alkylation of 3-thioGalNAc.
Journal of the American Chemical Society 2001;123(8):1587-95.
2001: Howard C Hang; Carolyn R Bertozzi
Ketone isosteres of 2-N-acetamidosugars as substrates for metabolic cell surface engineering.
Journal of the American Chemical Society 2001;123(6):1242-3.
2001: Eliana Saxon; Carolyn R Bertozzi
Chemical and biological strategies for engineering cell surface glycosylation.
Annual review of cell and developmental biology 2001;17():1-23.
2001: Kevin J Yarema; Carolyn R Bertozzi
Characterizing glycosylation pathways.
Genome biology 2001;2(5):REVIEWS0004.
2000: S Bhakta; A Bartes; KG Bowman; W M Kao; I Polsky; Jin Kyu Lee; Brian N Cook; RE Bruehl; Steven D Rosen; Carolyn R Bertozzi; Stefan Hemmerich
Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5).
The Journal of biological chemistry 2000;275(51):40226-34.
2000: RE Bruehl; Carolyn R Bertozzi; Steven D Rosen
Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody.
The Journal of biological chemistry 2000;275(42):32642-8.
2000: Neil W Charter; Lara K Mahal; Daniel E Koshland; Carolyn R Bertozzi
Biosynthetic incorporation of unnatural sialic acids into polysialic acid on neural cells.
Glycobiology 2000;10(10):1049-56.
2000: Joshua I Armstrong; Carolyn R Bertozzi
Sulfotransferases as targets for therapeutic intervention.
Current opinion in drug discovery & development 2000;3(5):502-15.
2000: Eliana Saxon; Joshua I Armstrong; Carolyn R Bertozzi
A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds.
Organic letters 2000;2(14):2141-3.
2000: Eliana Saxon; Carolyn R Bertozzi
Cell surface engineering by a modified Staudinger reaction.
Science (New York, N.Y.) 2000;287(5460):2007-10.
2000: John W Kehoe; Carolyn R Bertozzi
Tyrosine sulfation: a modulator of extracellular protein-protein interactions.
Chemistry & biology 2000;7(3):R57-61.
2000: C L Jacobs; Kevin J Yarema; Lara K Mahal; D A Nauman; N W Charters; Carolyn R Bertozzi
Metabolic labeling of glycoproteins with chemical tags through unnatural sialic acid biosynthesis.
Methods in enzymology 2000;327():260-75.
1999: Katharine A Winans; David S King; V R Rao; Carolyn R Bertozzi
A chemically synthesized version of the insect antibacterial glycopeptide, diptericin, disrupts bacterial membrane integrity.
Biochemistry 1999;38(36):11700-10.
1999: J H Lee; T J Baker; L K Mahal; Joseph Zabner; Carolyn R Bertozzi; David F Wiemer; Michael J Welsh
Engineering novel cell surface receptors for virus-mediated gene transfer.
The Journal of biological chemistry 1999;274(31):21878-84.
1999: KG Bowman; Carolyn R Bertozzi
Carbohydrate sulfotransferases: mediators of extracellular communication.
Chemistry & biology 1999;6(1):R9-R22.
1998: George A Lemieux; Carolyn R Bertozzi
Chemoselective ligation reactions with proteins, oligosaccharides and cells.
Trends in biotechnology 1998;16(12):506-13.
1998: Katharine A Winans; Carolyn R Bertozzi
Inner space exploration: the chemical biologist's guide to the cell.
Chemistry & biology 1998;5(12):R313-5.
1998: Kevin J Yarema; Lara K Mahal; R E Bruehl; E C Rodriguez; Carolyn R Bertozzi
Metabolic delivery of ketone groups to sialic acid residues. Application To cell surface glycoform engineering.
The Journal of biological chemistry 1998;273(47):31168-79.
1998: KG Bowman; Stefan Hemmerich; S Bhakta; Mark S Singer; Annette Bistrup; Steven D Rosen; Carolyn R Bertozzi
Identification of an N-acetylglucosamine-6-0-sulfotransferase activity specific to lymphoid tissue: an enzyme with a possible role in lymphocyte homing.
Chemistry & biology 1998;5(8):447-60.
1998: Kevin J Yarema; Carolyn R Bertozzi
Chemical approaches to glycobiology and emerging carbohydrate-based therapeutic agents.
Current opinion in chemical biology 1998;2(1):49-61.
1997: Lara K Mahal; Carolyn R Bertozzi
Engineered cell surfaces: fertile ground for molecular landscaping.
Chemistry & biology 1997;4(6):415-22.
1997: Lara K Mahal; Kevin J Yarema; Carolyn R Bertozzi
Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis.
Science (New York, N.Y.) 1997;276(5315):1125-8.
1997: Carolyn R Bertozzi; Mark S Singer; Steven D Rosen
An ELISA for selectins based on binding to a physiological ligand.
Journal of immunological methods 1997;203(2):157-65.
1996: W J Sanders; T R Katsumoto; Carolyn R Bertozzi; S D Rosen; Laura L Kiessling
L-selectin-carbohydrate interactions: relevant modifications of the Lewis x trisaccharide.
Biochemistry 1996;35(47):14862-7.
1996: Steven D Rosen; Carolyn R Bertozzi
Two selectins converge on sulphate. Leukocyte adhesion.
Current biology : CB 1996;6(3):261-4.
1995: Carolyn R Bertozzi; S Fukuda; Steven D Rosen
Sulfated disaccharide inhibitors of L-selectin: deriving structural leads from a physiological selectin ligand.
Biochemistry 1995;34(44):14271-8.
1995: Carolyn R Bertozzi
Cracking the carbohydrate code for selectin recognition.
Chemistry & biology 1995;2(11):703-8.
1994: Steven D Rosen; Carolyn R Bertozzi
The selectins and their ligands.
Current opinion in cell biology 1994;6(5):663-73.
1994: Stefan Hemmerich; Carolyn R Bertozzi; Hakon Leffler; Steven D Rosen
Identification of the sulfated monosaccharides of GlyCAM-1, an endothelial-derived ligand for L-selectin.
Biochemistry 1994;33(16):4820-9.
1992: J J Grabowski; Carolyn R Bertozzi; J R Jacobsen; A Jain; E M Marzluff; A Y Suh
Fluorescence probes in biochemistry: an examination of the non-fluorescent behavior of dansylamide by photoacoustic calorimetry.
Analytical biochemistry 1992;207(2):214-26.
1992: Carolyn R Bertozzi; Mark D Bednarski
C-glycosyl compounds bind to receptors on the surface of Escherichia coli and can target proteins to the organism.
Carbohydrate research 1992;223():243-53.