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Philip Portoghese

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Marco Pravetoni; Ashli M Tucker; Philip S Portoghese; Theresa M Harmon; Tara M Hawley; Morgan Le Naour; Paul R Pentel
Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.
Ajay S Yekkirala; Kenner C Rice; Matthew L Banks; Mary M Lunzer; Stevens S Negus; Philip S Portoghese
Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys.
Matthew D Metcalf; Carolyn A Fairbanks; Kelley F Kitto; Michael D Powers; George L Wilcox; Ajay S Yekkirala; Philip S Portoghese
The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors.

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2013: Marco Pravetoni; Ashli M Tucker; Philip S Portoghese; Theresa M Harmon; Tara M Hawley; Morgan Le Naour; Paul R Pentel
Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.
Journal of medicinal chemistry 2013;56(3):915-23.
2012: Ajay S Yekkirala; Kenner C Rice; Matthew L Banks; Mary M Lunzer; Stevens S Negus; Philip S Portoghese
Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys.
ACS chemical neuroscience 2012;3(9):720-7.
2012: Matthew D Metcalf; Carolyn A Fairbanks; Kelley F Kitto; Michael D Powers; George L Wilcox; Ajay S Yekkirala; Philip S Portoghese
The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors.
ACS chemical neuroscience 2012;3(7):505-9.
2012: Marco Pravetoni; M D Raleigh; A M Tucker; Philip S Portoghese; A K Birnbaum; T M Harmon; J M Jones; Morgan Le Naour; Paul R Pentel
Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats.
Vaccine 2012;30(31):4617-24.
2012: Erin E Cawston; Maoqing Dong; Kaleeckal harikumar; Polo C-H Lam; Ruben Abagyan; Eyup Akgün; Mary Lou Augustine; Alicja M Ball; Andrew Orry; Philip S Portoghese; Patrick M Sexton; Laurence J Miller
Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.
The Journal of biological chemistry 2012;287(22):18618-35.
2012: Kelly Berg; Lakshmi A Devi; Ivone Gomes; Achla Gupta; Kenneth Hargreaves; Blaine A McGuire; Philip S Portoghese; Matthew P Rowan; Teresa A Sanchez; Michelle Silva; William Clarke
Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons.
Molecular pharmacology 2012;81(2):264-72.
2012: Morgan Le Naour; Mary M Lunzer; Mike D Powers; Philip S Portoghese
Opioid activity of spinally selective analogues of N-naphthoyl-β-naltrexamine in HEK-293 cells and mice.
Journal of medicinal chemistry 2012;55(2):670-7.
2011: Troy B Adams; Samuel M Cohen; Victor J Feron; C Lucas Gavin; Lawrence J Marnett; M M McGowen; Ian C Munro; Philip S Portoghese; I M C M Rietjens; William J Waddell; Robert L Smith
The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(10):2471-94.
2011: Ajay S Yekkirala; Mary M Lunzer; Christopher R McCurdy; Michael D Powers; Alexander E Kalyuzhny; Sandra C Roerig; Philip S Portoghese
N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):5098-103.
2010: Michael A Ansonoff; Philip S Portoghese; John E Pintar
Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.
Psychopharmacology 2010;210(2):161-8.
2010: Kaleeckal harikumar; Eyup Akgün; Philip S Portoghese; Laurence J Miller
Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization.
Journal of medicinal chemistry 2010;53(7):2836-42.
2010: Ajay S Yekkirala; Alexander E Kalyuzhny; Philip S Portoghese
Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists.
ACS chemical neuroscience 2010;1(2):146-54.
2009: Shijun Zhang; Ajay Yekkirala; Ye Tang; Philip S Portoghese
A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors.
Bioorganic & medicinal chemistry letters 2009;19(24):6978-80.
2009: Eyup Akgün; Meike Körner; Fan Gao; Kaleeckal harikumar; Beatrice Waser; Jean Claude Reubi; Philip S Portoghese; Laurence J Miller
Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors.
Journal of medicinal chemistry 2009;52(7):2138-47.
2009: Yaguo Zheng; Eyup Akgün; Kaleeckal harikumar; Jessika Hopson; Michael D Powers; Mary M Lunzer; Laurence J Miller; Philip S Portoghese
Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands.
Journal of medicinal chemistry 2009;52(2):247-58.
2009: Philip S Portoghese
Revision of purity criteria for tested compounds.
Journal of medicinal chemistry 2009;52(1):1.
2008: Troy B Adams; C Lucas Gavin; S V Taylor; William J Waddell; Samuel M Cohen; Victor J Feron; J Goodman; I M C M Rietjens; Lawrence J Marnett; Philip S Portoghese; Robert L Smith
The FEMA GRAS assessment of alpha,beta-unsaturated aldehydes and related substances used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(9):2935-67.
2007: Sarika Prabhu Haris; Yan Zhang; Bertrand Le Bourdonnec; Christopher R McCurdy; Philip S Portoghese
o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label.
Journal of medicinal chemistry 2007;50(14):3392-6.
2007: Natalie R Lenard; David J Daniels; Philip S Portoghese; Sandra C Roerig
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.
European journal of pharmacology 2007;566(1-3):75-82.
2007: Mary M Lunzer; Philip S Portoghese
Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.
The Journal of pharmacology and experimental therapeutics 2007;322(1):166-71.
2007: Mary M Lunzer; Ajay Yekkirala; Robert P Hebbel; Philip S Portoghese
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):6061-5.
2007: Troy B Adams; M M McGowen; M C Williams; Samuel M Cohen; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell
The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(2):171-201.
2005: David J Daniels; Natalie R Lenard; Chris L Etienne; Ping-Yee Law; Sandra C Roerig; Philip S Portoghese
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19208-13.
2005: Zhihua Xie; Rashmi G Bhushan; David J Daniels; Philip S Portoghese
Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells.
Molecular pharmacology 2005;68(4):1079-86.
2005: Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1241-71.
2005: Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1207-40.
2005: Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of phenethyl alcohol, aldehyde, acid, and related acetals and esters used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1179-206.
2005: Robert L Smith; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; William J Waddell; Bernard M Wagner; Troy B Adams
Criteria for the safety evaluation of flavoring substances. The Expert Panel of the Flavor and Extract Manufacturers Association.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1141-77.
2005: Maria Waldhoer; Jamie Fong; Robert M Jones; Mary M Lunzer; Shiv K Sharma; Evi Kostenis; Philip S Portoghese; Jennifer L Whistler
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(25):9050-5.
2005: Yan Zhang; Yuk Y Sham; Ramkumar Rajamani; Jiali Gao; Philip S Portoghese
Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system.
Chembiochem : a European journal of chemical biology 2005;6(5):853-9.
2005: David J Daniels; Amol Kulkarni; Zhihua Xie; Rashmi G Bhushan; Philip S Portoghese
A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.
Journal of medicinal chemistry 2005;48(6):1713-6.
2005: Robert L Smith; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Philip S Portoghese; William J Waddell; Bernard M Wagner; RL Hall; N A Higley; C Lucas-Gavin; Troy B Adams
A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(3):345-63.
2005: Emily Jutkiewicz; Nicholas P Walker; John E Folk; Kenner C Rice; Philip S Portoghese; James H Woods; John R Traynor
Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats.
The Journal of pharmacology and experimental therapeutics 2005;312(3):1314-20.
2005: Yan Zhang; Christopher R McCurdy; Thomas G Metzger; Philip S Portoghese
Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label.
Biochemistry 2005;44(7):2271-5.
2004: Rashmi G Bhushan; Shiv K Sharma; Zhihua Xie; David J Daniels; Philip S Portoghese
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.
Journal of medicinal chemistry 2004;47(12):2969-72.
2004: Robert L Smith; Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; RL Hall; Lawrence J Marnett; Philip S Portoghese; William J Waddell; Bernard M Wagner
Safety evaluation of natural flavour complexes.
Toxicology letters 2004;149(1-3):197-207.
2004: Mark S Todtenkopf; Jacqueline F Marcus; Philip S Portoghese; William A Carlezon
Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats.
Psychopharmacology 2004;172(4):463-70.
2004: Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(2):157-85.
2004: DeWayne Townsend; Philip S Portoghese; David R Brown
Characterization of specific opioid binding sites in neural membranes from the myenteric plexus of porcine small intestine.
The Journal of pharmacology and experimental therapeutics 2004;308(1):385-93.
2003: Philip S Portoghese; Ping-Yee Law; Horace H Loh
Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens.
European journal of pharmacology 2003;478(2-3):207-10.
2003: Philip S Portoghese; Mary M Lunzer
Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord.
European journal of pharmacology 2003;467(1-3):233-4.
2003: Stephen D Mague; Andrea M Pliakas; Mark S Todtenkopf; Hilarie C Tomasiewicz; Yan Zhang; William C Stevens; Robert M Jones; Philip S Portoghese; William A Carlezon
Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats.
The Journal of pharmacology and experimental therapeutics 2003;305(1):323-30.
2002: S Stevens Negus; Nancy K Mello; David C Linsenmayer; R M Jones; Philip S Portoghese
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
Psychopharmacology 2002;163(3-4):412-9.
2002: Christopher R McCurdy; Bertrand Le Bourdonnec; Thomas G Metzger; Rachid El Kouhen; Yan Zhang; Ping-Yee Law; Philip S Portoghese
Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties.
Journal of medicinal chemistry 2002;45(14):2887-90.
2002: Robert L Smith; Troy B Adams; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Philip S Portoghese; William J Waddell; Bernard M Wagner; Adrianne E Rogers; John Caldwell; IG Sipes
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(7):851-70.
2002: Troy B Adams; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Paul M Newberne; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Flavor and Extract Manufacturers Association.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(4):429-51.
2002: Jodie J Rady; Philip S Portoghese; James M Fujimo
Methadone and heroin antinociception: predominant delta-opioid-receptor responses in methadone-tolerant mice.
Japanese journal of pharmacology 2002;88(3):319-31.
2001: Philip S Portoghese
From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes.
Journal of medicinal chemistry 2001;44(14):2259-69.
2001: S K Sharma; RM Jones; Thomas G Metzger; David M Ferguson; Philip S Portoghese
Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole.
Journal of medicinal chemistry 2001;44(13):2073-9.
2001: Bertrand Le Bourdonnec; Rachid El Kouhen; Gennady Poda; Ping-Yee Law; Horace H Loh; David M Ferguson; Philip S Portoghese
Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI).
Journal of medicinal chemistry 2001;44(7):1017-20.
2001: Thomas G Metzger; M Germana Paterlini; David M Ferguson; Philip S Portoghese
Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus.
Journal of medicinal chemistry 2001;44(6):857-62.
2001: Philip S Portoghese; Rachid El Kouhen; Ping-Yee Law; Horace H Loh; Bertrand Le Bourdonnec
Affinity labels as tools for the identification of opioid receptor recognition sites.
Farmaco (Società chimica italiana : 1989) 2001;56(3):191-6.
2000: W C Stevens; RM Jones; Govindan Subramanian; Thomas G Metzger; David M Ferguson; Philip S Portoghese
Potent and selective indolomorphinan antagonists of the kappa-opioid receptor.
Journal of medicinal chemistry 2000;43(14):2759-69.
2000: Bertrand Le Bourdonnec; Rachid El Kouhen; Mary M Lunzer; Ping-Yee Law; Horace H Loh; Philip S Portoghese
Reporter affinity labels: an o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors.
Journal of medicinal chemistry 2000;43(13):2489-92.
2000: Jodie J Rady; Blythe B Holmes; Philip S Portoghese; James M Fujimoto
Morphine tolerance in mice changes response of heroin from mu to delta opioid receptors.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 2000;224(2):93-101.
2000: RM Jones; Philip S Portoghese
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
European journal of pharmacology 2000;396(1):49-52.
2000: DL Larson; RM Jones; S A Hjorth; T W Schwartz; Philip S Portoghese
Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists.
Journal of medicinal chemistry 2000;43(8):1573-6.
2000: David M Ferguson; S Kramer; Thomas G Metzger; Ping-Yee Law; Philip S Portoghese
Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.
Journal of medicinal chemistry 2000;43(7):1251-2.
2000: Christopher R McCurdy; RM Jones; Philip S Portoghese
Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone.
Organic letters 2000;2(6):819-21.
2000: Govindan Subramanian; M Germana Paterlini; Philip S Portoghese; David M Ferguson
Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor.
Journal of medicinal chemistry 2000;43(3):381-91.
2000: M Germana Paterlini; F Avitabile; B G Ostrowski; David M Ferguson; Philip S Portoghese
Stereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1.
Biophysical journal 2000;78(2):590-9.
1999: Paul M Newberne; Robert L Smith; John Doull; Jay I Goodman; Ian C Munro; Philip S Portoghese; Bernard M Wagner; CS Weil; LA Woods; Troy B Adams; C D Lucas; RA Ford
The FEMA GRAS assessment of trans-anethole used as a flavouring substance. Flavour and Extract Manufacturer's Association.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(7):789-811.
1998: RM Jones; S A Hjorth; T W Schwartz; Philip S Portoghese
Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors.
Journal of medicinal chemistry 1998;41(25):4911-4.
1998: Govindan Subramanian; M Germana Paterlini; DL Larson; Philip S Portoghese; David M Ferguson
Conformational analysis and automated receptor docking of selective arylacetamide-based kappa-opioid agonists.
Journal of medicinal chemistry 1998;41(24):4777-89.
1998: S Ohkawa; Philip S Portoghese
7-Arylidenenaltrexones as selective delta1 opioid receptor antagonists.
Journal of medicinal chemistry 1998;41(21):4177-80.
1998: P Gao; DL Larson; Philip S Portoghese
Synthesis of 7-arylmorphinans. Probing the "address" requirements for selectivity at opioid delta receptors.
Journal of medicinal chemistry 1998;41(16):3091-8.
1998: T A Kshirsagar; X Fang; Philip S Portoghese
14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors.
Journal of medicinal chemistry 1998;41(14):2657-60.
1998: T Kshirsagar; A H Nakano; Ping-Yee Law; Robert Elde; Philip S Portoghese
NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors.
Neuroscience letters 1998;249(2-3):83-6.
1998: Troy B Adams; D B Greer; John Doull; Ian C Munro; Paul M Newberne; Philip S Portoghese; Robert L Smith; Bernard M Wagner; CS Weil; LA Woods; RA Ford
The FEMA GRAS assessment of lactones used as a flavour ingredients. The Flavor and Extract Manufacturers' Association. Generally recognized as safe.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(4):249-78.
1997: Mary J Clark; PJ Emmerson; A Mansour; Huda Akil; James H Woods; Philip S Portoghese; Ann E Remmers; F Medzihradsky
Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor.
The Journal of pharmacology and experimental therapeutics 1997;283(2):501-10.
1997: G Paterlini; Philip S Portoghese; David M Ferguson
Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioid receptor. A model for receptor activation.
Journal of medicinal chemistry 1997;40(20):3254-62.
1997: X Fang; DL Larson; Philip S Portoghese
7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.
Journal of medicinal chemistry 1997;40(19):3064-70.
1997: Troy B Adams; John Doull; Jay I Goodman; Ian C Munro; Paul M Newberne; Philip S Portoghese; Robert L Smith; Bernard M Wagner; CS Weil; LA Woods; RA Ford
The FEMA GRAS assessment of furfural used as a flavour ingredient. Flavor and Extract Manufacturers' Association.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(8):739-51.
1997: V M Goettl; DL Larson; Philip S Portoghese; A A Larson
Inhibition of substance P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice.
Pain 1997;71(3):271-8.
1997: S Stevens Negus; Nancy K Mello; Philip S Portoghese; C E Lin
Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 1997;282(1):44-55.
1997: F Farouz-Grant; Philip S Portoghese
Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.
Journal of medicinal chemistry 1997;40(13):1977-81.
1997: S Ohkawa; B DiGiacomo; DL Larson; A E Takemori; Philip S Portoghese
7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.
Journal of medicinal chemistry 1997;40(11):1720-5.
1997: Jodie J Rady; D Baemmert; A E Takemori; Philip S Portoghese; James M Fujimoto
Spinal delta opioid receptor subtype activity of 6-monoacetylmorphine in Swiss Webster mice.
Pharmacology, biochemistry, and behavior 1997;56(2):243-9.
1996: T G Metzger; M Germana Paterlini; Philip S Portoghese; David M Ferguson
Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models.
Neurochemical research 1996;21(11):1287-94.
1996: Troy B Adams; J B Hallagan; J M Putnam; T L Gierke; John Doull; Ian C Munro; Paul M Newberne; Philip S Portoghese; Robert L Smith; Bernard M Wagner; C S Weil; L A Woods; R A Ford
The FEMA GRAS assessment of alicyclic substances used as flavour ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(9):763-828.
1996: T G Metzger; M Germana Paterlini; Philip S Portoghese; David M Ferguson
An analysis of the conserved residues between halobacterial retinal proteins and G-protein coupled receptors: implications for GPCR modeling.
Journal of chemical information and computer sciences 1996;36(4):857-61.
1996: M L Bolognesi; William H Ojala; WB Gleason; J F Griffin; F Farouz-Grant; DL Larson; A E Takemori; Philip S Portoghese
Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide "address" recognition at kappa opioid receptors.
Journal of medicinal chemistry 1996;39(9):1816-22.
1996: A C Chang; C C Chao; A E Takemori; G Gekker; S Hu; P K Peterson; Philip S Portoghese
Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells.
Journal of medicinal chemistry 1996;39(8):1729-35.
1995: V L Korlipara; A E Takemori; Philip S Portoghese
Electrophilic N-benzylnaltrindoles as delta opioid receptor-selective antagonists.
Journal of medicinal chemistry 1995;38(8):1337-43.
1995: Philip S Portoghese; F Farouz-Grant; M Sultana; A E Takemori
7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of delta 1 opioid receptor-mediated antinociception in mice.
Journal of medicinal chemistry 1995;38(3):402-7.
1994: A C Chang; A E Takemori; William H Ojala; WB Gleason; Philip S Portoghese
kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists.
Journal of medicinal chemistry 1994;37(26):4490-8.
1994: Philip S Portoghese; S Ohkawa; S T Moe; A E Takemori
Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety.
Journal of medicinal chemistry 1994;37(12):1886-8.
1994: V L Korlipara; A E Takemori; Philip S Portoghese
N-benzylnaltrindoles as long-acting delta-opioid receptor antagonists.
Journal of medicinal chemistry 1994;37(12):1882-5.
1994: A C Chang; A E Takemori; Philip S Portoghese
2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice.
Journal of medicinal chemistry 1994;37(11):1547-9.
1994: Philip S Portoghese; C E Lin; F Farouz-Grant; A E Takemori
Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor.
Journal of medicinal chemistry 1994;37(10):1495-500.
1994: Philip S Portoghese; M Sultana; S T Moe; A E Takemori
Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety.
Journal of medicinal chemistry 1994;37(5):579-85.
1993: Philip S Portoghese; S T Moe; A E Takemori
A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists.
Journal of medicinal chemistry 1993;36(17):2572-4.
1993: C E Lin; A E Takemori; Philip S Portoghese
Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity.
Journal of medicinal chemistry 1993;36(16):2412-5.
1993: Ian C Munro; Elke Kennepohl; R E Erickson; Philip S Portoghese; Bernard M Wagner; O D Easterday; C H Manley
Safety assessment of ingested heterocyclic amines: initial report.
Regulatory toxicology and pharmacology : RTP 1993;17(2 Pt 2):S1-109.
1993: Philip S Portoghese
The design of delta-selective opioid receptor antagonists.
Farmaco (Società chimica italiana : 1989) 1993;48(2):243-51.
1993: S L Olmsted; A E Takemori; Philip S Portoghese
A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists.
Journal of medicinal chemistry 1993;36(1):179-80.
1992: Philip S Portoghese; DL Larson; M Sultana; A E Takemori
Opioid agonist and antagonist activities of morphindoles related to naltrindole.
Journal of medicinal chemistry 1992;35(23):4325-9.
1992: Philip S Portoghese; M Sultana; W L Nelson; P Klein; A E Takemori
Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes.
Journal of medicinal chemistry 1992;35(22):4086-91.
1992: Philip S Portoghese; M Sultana; H Nagase; A E Takemori
A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone.
European journal of pharmacology 1992;218(1):195-6.
1992: Philip S Portoghese
Edward E. Smissman-Bristol-Myers Squibb Award Address. The role of concepts in structure-activity relationship studies of opioid ligands.
Journal of medicinal chemistry 1992;35(11):1927-37.
1992: Philip S Portoghese
Chemical tools in opioid research.
NIDA research monograph 1992;119():27-33.
1991: Philip S Portoghese; A Garzon-Aburbeh; DL Larson
Persistent binding of fatty acyl derivatives of naltrexamine to opioid receptors.
Journal of medicinal chemistry 1991;34(7):1966-9.
1991: Philip S Portoghese
An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.
Journal of medicinal chemistry 1991;34(6):1757-62.
1991: Philip S Portoghese; H Nagase; K E MaloneyHuss; C E Lin; A E Takemori
Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.
Journal of medicinal chemistry 1991;34(5):1715-20.
1991: Philip S Portoghese; A Garzon-Aburbeh; H Nagase; C E Lin; A E Takemori
Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine.
Journal of medicinal chemistry 1991;34(4):1292-6.
1990: Philip S Portoghese; M Sultana; A E Takemori
Design of peptidomimetic delta opioid receptor antagonists using the message-address concept.
Journal of medicinal chemistry 1990;33(6):1714-20.
1990: Philip S Portoghese
The bivalent ligand approach in the design of highly selective opioid receptor antagonists.
NIDA research monograph 1990;96():3-20.
1989: S Botros; A W Lipkowski; DL Larson; P A Stark; A E Takemori; Philip S Portoghese
Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine.
Journal of medicinal chemistry 1989;32(9):2068-71.
1988: Philip S Portoghese; H Nagase; A E Takemori
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
Journal of medicinal chemistry 1988;31(7):1344-7.
1988: Philip S Portoghese; H Nagase; A W Lipkowski; DL Larson; A E Takemori
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Journal of medicinal chemistry 1988;31(4):836-41.
1988: Philip S Portoghese; M Sultana; H Nagase; A E Takemori
Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists.
Journal of medicinal chemistry 1988;31(2):281-2.
1988: Philip S Portoghese; M Sultana; A E Takemori
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.
European journal of pharmacology 1988;146(1):185-6.
1987: Philip S Portoghese; D L Larson; G Ronsisvalle; P W Schiller; T M Nguyen; C Lemieux; A E Takemori
Hybrid bivalent ligands with opiate and enkephalin pharmacophores.
Journal of medicinal chemistry 1987;30(11):1991-4.
1986: S Botros; A W Lipkowski; A E Takemori; Philip S Portoghese
Investigation of the structural requirements for the kappa-selective opioid receptor antagonist, 6 beta,6 beta'-[ethylenebis(oxyethyleneimino)]bis[17-(cyclopropylmethyl)- 4,5 alpha-epoxymorphinan-3,14-diol] (TENA).
Journal of medicinal chemistry 1986;29(5):874-6.
1986: J A Lovett; Philip S Portoghese
Melphalan-containing N,N-dialkylenkephalin analogs as potential irreversible antagonists of the delta opioid receptor.
NIDA research monograph 1986;75():185-8.