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Gary Posner

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Chemicals & Drugs

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Malaria

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Bryan T Mott; Maxime A Siegler; David Sullivan; Abhai Tripathi; Cathy D Moore; Gary H Posner
Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.
Alexander M Jacobine; Jennifer R Mazzone; Rachel D Slack; David Sullivan; Abhai K Tripathi; Gary H Posner
Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.
Ran He; Arun Kapoor; Bryan Mott; Kyoungsook Park; Gary H Posner; Hongyi Cai; M Forman; RAVIT BOGER
Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication.

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All Publications

2013: Bryan T Mott; Maxime A Siegler; David Sullivan; Abhai Tripathi; Cathy D Moore; Gary H Posner
Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.
Journal of medicinal chemistry 2013;56(6):2630-41.
2012: Alexander M Jacobine; Jennifer R Mazzone; Rachel D Slack; David Sullivan; Abhai K Tripathi; Gary H Posner
Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.
Journal of medicinal chemistry 2012;55(17):7892-9.
2012: Ran He; Arun Kapoor; Bryan Mott; Kyoungsook Park; Gary H Posner; Hongyi Cai; M Forman; RAVIT BOGER
Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication.
Antimicrobial agents and chemotherapy 2012;56(7):3508-15.
2011: Douglas T Genna; Gary H Posner
Cyanocuprates convert carboxylic acids directly into ketones.
Organic letters 2011;13(19):5358-61.
2011: Alexander M Jacobine; Gary H Posner
Three-component, one-flask synthesis of rhodanines (thiazolidinones).
The Journal of organic chemistry 2011;76(19):8121-5.
2011: Christopher P Hencken; Douglas T Genna; Maxime A Siegler; Gary H Posner
Highly stereocontrolled and regiocontrolled syntheses of 2,3,4-trisubstituted alkanoates and lactones.
The Journal of organic chemistry 2011;76(12):5149-55.
2011: Deuk Kyu Moon; Abhai Tripathi; David Sullivan; Maxime A Siegler; Sean Parkin; Gary H Posner
A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.
Bioorganic & medicinal chemistry letters 2011;21(9):2773-5.
2011: Ran He; Bryan T Mott; Gary H Posner; Andrew S Rosenthal; Douglas T Genna; RAVIT BOGER
An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities.
PloS one 2011;6(8):e24334.
2011: Ran He; GORDON SANDFORD; Gary S Hayward; William H Burns; Gary H Posner; Michael Forman; RAVIT BOGER
Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors.
Virology journal 2011;8():40.
2010: Douglas T Genna; Christopher P Hencken; Maxime A Siegler; Gary H Posner
α-Chloro-β,γ-ethylenic esters: enantiocontrolled synthesis and substitutions.
Organic letters 2010;12(20):4694-7.
2010: Gary H Posner; Christian Helvig; Dominic Cuerrier; Drew Collop; Aza Kharebov; Kara Ryder; Tina Epps; Martin Petkovich
Vitamin D analogues targeting CYP24 in chronic kidney disease.
The Journal of steroid biochemistry and molecular biology 2010;121(1-2):13-9.
2010: Christopher P Hencken; LORRAINE BRANDO; Claudia Bordón; Remo Stohler; Bryan T Mott; Robert H Yolken; Gary H Posner; Lauren E Woodard
Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii.
Journal of medicinal chemistry 2010;53(9):3594-601.
2010: Lindsey C Hess; Gary H Posner
Asymmetric, organocatalytic, three-step synthesis of alpha-hydroxy-(E)-beta,gamma-unsaturated esters.
Organic letters 2010;12(9):2120-2.
2010: RAVIT BOGER; Ran He; Chuang-Jiun Chiou; Jianyong Liu; Lauren Woodard; Andrew Rosenthal; LORRAINE BRANDO; M Forman; Gary H Posner
Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers.
PloS one 2010;5(4):e10370.
2009: Lauren E Woodard; Wonsuk Chang; Xiaochun Chen; Jun O Liu; Theresa A Shapiro; Gary H Posner
Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.
Journal of medicinal chemistry 2009;52(23):7458-62.
2009: Aimee R Usera; Patrick Dolan; Thomas W Kensler; Gary H Posner
'Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities'.
Bioorganic & medicinal chemistry 2009;17(15):5627-31.
2009: Andrew S Rosenthal; Xiaochun Chen; Jun O Liu; Diana C West; Paul J Hergenrother; Theresa A Shapiro; Gary H Posner
Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.
Journal of medicinal chemistry 2009;52(4):1198-203.
2008: Gary H Posner; William A Maio; Alvin S Kalinda
Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate.
Bioorganic & medicinal chemistry 2008;16(9):5247-53.
2008: Gary H Posner; Wonsuk Chang; Lindsey Hess; Lauren Woodard; Sandra Sinishtaj; Aimee R Usera; William Maio; Andrew S Rosenthal; Alvin S Kalinda; John G D'Angelo; Kimberly S Petersen; Remo Stohler; Jacques Chollet; Josefina Santo-Tomas; Christopher Snyder; Matthias Rottmann; Sergio Wittlin; Reto Brun; Theresa A Shapiro
Malaria-infected mice are cured by oral administration of new artemisinin derivatives.
Journal of medicinal chemistry 2008;51(4):1035-42.
2007: Kimberly S Petersen; Patrick Dolan; Thomas W Kensler; Sara Peleg; Gary H Posner
Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.
Journal of medicinal chemistry 2007;50(23):5824-32.
2007: Aimee R Usera; Patrick Dolan; Thomas W Kensler; Gary H Posner
Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1alpha,25-dihydroxyvitamin D3: chemical synthesis and biological evaluation.
Bioorganic & medicinal chemistry 2007;15(16):5509-18.
2007: William A Maio; Sandra Sinishtaj; Gary H Posner
Cyclopentanone ring expansion leading to functionalized delta-lactams: short synthesis of simple sedum alkaloids.
Organic letters 2007;9(14):2673-6.
2007: Gary H Posner; Ik-Hyeon Paik; Wonsuk Chang; Kristina Borstnik; Sandra Sinishtaj; Andrew S Rosenthal; Theresa A Shapiro
Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.
Journal of medicinal chemistry 2007;50(10):2516-9.
2007: Aimee R Usera; Gary H Posner
Unexpected steric effects of "remote" alkyl groups on the rate of conjugate additions to alkyl alpha,beta-ethylenic sulfones, sulfoxides, and esters.
The Journal of organic chemistry 2007;72(7):2329-34.
2007: Gary H Posner; Byung Chul Suh; Kimberly S Petersen; Patrick Dolan; Elin Agoston; Thomas W Kensler; John T Koh; Sara Peleg
Difluoromethyl analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):213-21.
2006: Adebusola A Alagbala; Andrew J McRiner; Kristina Borstnik; Tanzina Labonte; Wonsuk Chang; John G D'Angelo; Gary H Posner; Barbara A Foster
Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.
Journal of medicinal chemistry 2006;49(26):7836-42.
2006: Sara Peleg; Kimberly S Petersen; Byung Chul Suh; Patrick Dolan; Elin Agoston; Thomas W Kensler; Gary H Posner
Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.
Journal of medicinal chemistry 2006;49(25):7513-7.
2006: LORRAINE BRANDO; John D'Angelo; Gary H Posner; Robert H Yolken
In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin.
Antimicrobial agents and chemotherapy 2006;50(12):4206-8.
2006: Sandra Sinishtaj; Heung Bae Jeon; Patrick Dolan; Thomas W Kensler; Gary H Posner
Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1alpha,25-dihydroxyvitamin D3.
Bioorganic & medicinal chemistry 2006;14(18):6341-8.
2006: Ik-Hyeon Paik; Suji Xie; Theresa A Shapiro; Tanzina Labonte; Amy A Narducci Sarjeant; Astrid C Baege; Gary H Posner
Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.
Journal of medicinal chemistry 2006;49(9):2731-4.
2006: Adebusola A Alagbala; Candace S Johnson; Donald L Trump; Gary H Posner; Barbara A Foster
Antitumor effects of two less-calcemic vitamin D analogs (Paricalcitol and QW-1624F2-2) in squamous cell carcinoma cells.
Oncology 2006;70(6):483-92.
2006: Elin Agoston; M A Hatcher; Thomas W Kensler; Gary H Posner
Vitamin D analogs as anti-carcinogenic agents.
Anti-cancer agents in medicinal chemistry 2006;6(1):53-71.
2005: Paul M O'Neill; Sarah L Rawe; Kristina Borstnik; Alison Miller; Stephen A Ward; Patrick G Bray; Jill Davies; Chang Ho Oh; Gary H Posner
Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.
Chembiochem : a European journal of chemical biology 2005;6(11):2048-54.
2005: Sara Peleg; Farhana Khan; Nora M Navone; Dianna D Cody; Evan M Johnson; Carolyn S Van Pelt; Gary H Posner
Inhibition of prostate cancer-meditated osteoblastic bone lesions by the low-calcemic analog 1alpha-hydroxymethyl-16-ene-26,27-bishomo-25-hydroxy vitamin D3.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):203-11.
2005: Gary H Posner; Hyung Jin Kim; Mehmet Kahraman; Heung Bae Jeon; Byung Chul Suh; Hongbin Li; Patrick Dolan; Thomas W Kensler
Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.
Bioorganic & medicinal chemistry 2005;13(19):5569-80.
2005: Gary H Posner; Mark A Hatcher; William A Maio
New silicon-mediated, sequential ring expansions of n-sized 2-cycloalkenones into hydroxyolefinic n + m + p medium-sized lactones: short synthesis of (-)-phoracantholide-J.
Organic letters 2005;7(19):4301-3.
2005: Mark A Hatcher; Sara Peleg; Patrick Dolan; Thomas W Kensler; Amy Sarjeant; Gary H Posner
A-ring hydroxymethyl 19-nor analogs of the natural hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.
Bioorganic & medicinal chemistry 2005;13(12):3964-76.
2005: Gary H Posner; S H Tony Lee; Hyung Jin Kim; Sara Peleg; Patrick Dolan; Thomas W Kensler
Novel A-ring analogs of the hormone 1alpha,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation.
Bioorganic & medicinal chemistry 2005;13(8):2959-66.
2004: Mehmet Kahraman; Sandra Sinishtaj; Patrick Dolan; Thomas W Kensler; Sara Peleg; Uttam Saha; Samuel S Chuang; Galina Bernstein; Bozena Korczak; Gary H Posner
Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3).
Journal of medicinal chemistry 2004;47(27):6854-63.
2004: Gary H Posner; Heung Bae Jeon; Amy Sarjeant; Edward S Riccio; Rupa Doppalapudi; Izet M Kapetanovic; Uttam Saha; Patrick Dolan; Thomas W Kensler
Low-calcemic, efficacious, 1alpha,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry.
Steroids 2004;69(11-12):757-62.
2004: Gary H Posner; Paul M O'Neill
Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.
Accounts of chemical research 2004;37(6):397-404.
2004: Gary H Posner; Kenneth R Crawford; Hong Woon Yang; Mehmet Kahraman; Heung Bae Jeon; Hongbin Li; Jae Kyoo Lee; Byung Chul Suh; Mark A Hatcher; Tanzina Labonte; Aimee R Usera; Patrick Dolan; Thomas W Kensler; Sara Peleg; Glenville Jones; Anqi Zhang; Bozena Korczak; Uttam Saha; Samuel S Chuang
Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):5-12.
2004: Gary H Posner; Andrew J McRiner; Ik-Hyeon Paik; Surojit Sur; Kristina Borstnik; Suji Xie; Theresa A Shapiro; Adebusola A Alagbala; Barbara Foster
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
Journal of medicinal chemistry 2004;47(5):1299-301.
2003: Mario D Bachi; Edward E Korshin; Roland Hoos; Alex M Szpilman; Poonsakdi Ploypradith; Suji Xie; Theresa A Shapiro; Gary H Posner
A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.
Journal of medicinal chemistry 2003;46(12):2516-33.
2003: Gary H Posner; John P Maxwell; Mehmet Kahraman
Mild, fast, and stereoselective epoxide opening by ketone enolate anions. Application to synthesis of the norlignan curculigine.
The Journal of organic chemistry 2003;68(8):3049-54.
2003: Gary H Posner; Ik-Hyeon Paik; Surojit Sur; Andrew J McRiner; Kristina Borstnik; Suji Xie; Theresa A Shapiro
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.
Journal of medicinal chemistry 2003;46(6):1060-5.
2003: Sara Peleg; Gary H Posner
Vitamin D analogs as modulators of vitamin D receptor action.
Current topics in medicinal chemistry 2003;3(14):1555-72.
2002: Kristina Borstnik; Ik-Hyeon Paik; Theresa A Shapiro; Gary H Posner
Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.
International journal for parasitology 2002;32(13):1661-7.
2002: Gary H Posner
Low-calcemic vitamin D analogs (deltanoids) for human cancer prevention.
The Journal of nutrition 2002;132(12):3802S-3803S.
2002: Kristina Borstnik; Ik-Hyeon Paik; Gary H Posner
Malaria: new chemotherapeutic peroxide drugs.
Mini reviews in medicinal chemistry 2002;2(6):573-83.
2002: Gary H Posner; Heung Bae Jeon; Poonsakdi Ploypradith; Ik-Hyeon Paik; Kristina Borstnik; Suji Xie; Theresa A Shapiro
Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.
Journal of medicinal chemistry 2002;45(18):3824-8.
2002: Gary H Posner; Benjamin T Woodard; Kenneth R Crawford; Sara Peleg; Alex J Brown; Patrick Dolan; Thomas W Kensler
2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology.
Bioorganic & medicinal chemistry 2002;10(7):2353-65.
2002: Gary H Posner; Bethany A Halford; Sara Peleg; Patrick Dolan; Thomas W Kensler
Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing.
Journal of medicinal chemistry 2002;45(8):1723-30.
2002: Gary H Posner; John Northrop; Ik-Hyeon Paik; Kristina Borstnik; Patrick Dolan; Thomas W Kensler; Suji Xie; Theresa A Shapiro
New chemical and biological aspects of artemisinin-derived trioxane dimers.
Bioorganic & medicinal chemistry 2002;10(1):227-32.
2001: Alex M Szpilman; Edward E Korshin; R Hoos; Gary H Posner; Mario D Bachi
Iron(II)-induced degradation of antimalarial beta-sulfonyl endoperoxides: evidence for the generation of potentially cytotoxic carbocations.
The Journal of organic chemistry 2001;66(20):6531-40.
2001: Gary H Posner; Heung Bae Jeon; Michael H Parker; M Krasavin; Ik-Hyeon Paik; Theresa A Shapiro
Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.
Journal of medicinal chemistry 2001;44(19):3054-8.
2001: Gary H Posner; Kenneth R Crawford; Sara Peleg; J E Welsh; S Romu; David Gewirtz; Mona S Gupta; Patrick Dolan; Thomas W Kensler
A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin.
Bioorganic & medicinal chemistry 2001;9(9):2365-71.
2001: S A Gardezi; C Nguyen; Peter J Malloy; Gary H Posner; D Feldman; Sara Peleg
A rationale for treatment of hereditary vitamin D-resistant rickets with analogs of 1 alpha,25-dihydroxyvitamin D(3).
The Journal of biological chemistry 2001;276(31):29148-56.
2001: M C White; Martin Burke; Sara Peleg; Henry Brem; Gary H Posner
Conformationally restricted hybrid analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): design, synthesis, and biological evaluation.
Bioorganic & medicinal chemistry 2001;9(7):1691-9.
2000: Gary H Posner; Kenneth R Crawford; Mei-Ling Siu-Caldera; G Satyanarayana Reddy; Stephen Sarabia; David Feldman; E van Etten; C Mathieu; Lynn A Gennaro; Paul Vouros; Sara Peleg; Patrick Dolan; Thomas W Kensler
Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation.
Journal of medicinal chemistry 2000;43(19):3581-6.
2000: Gary H Posner; J P Maxwell; H O'Dowd; M Krasavin; Suji Xie; Theresa A Shapiro
Antimalarial sulfide, sulfone, and sulfonamide trioxanes.
Bioorganic & medicinal chemistry 2000;8(6):1361-70.
1999: Gary H Posner; Poonsakdi Ploypradith; Michael H Parker; H O'Dowd; S H Woo; John Northrop; M Krasavin; Patrick Dolan; Thomas W Kensler; Suji Xie; Theresa A Shapiro
Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.
Journal of medicinal chemistry 1999;42(21):4275-80.
1999: Gary H Posner; Q Wang; G Han; J K Lee; Kenneth R Crawford; S Zand; Henry Brem; Sara Peleg; Patrick Dolan; Thomas W Kensler
Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.
Journal of medicinal chemistry 1999;42(18):3425-35.
1999: Gary H Posner; Michael H Parker; John Northrop; J S Elias; Poonsakdi Ploypradith; Suji Xie; Theresa A Shapiro
Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.
Journal of medicinal chemistry 1999;42(2):300-4.
1998: Gary H Posner; J K Lee; Q Wang; Sara Peleg; Martin Burke; Henry Brem; Patrick Dolan; Thomas W Kensler
Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation.
Journal of medicinal chemistry 1998;41(16):3008-14.
1998: Gary H Posner; H O'Dowd; Poonsakdi Ploypradith; JN Cumming; Suji Xie; Theresa A Shapiro
Antimalarial cyclic peroxy ketals.
Journal of medicinal chemistry 1998;41(12):2164-7.
1998: Mario D Bachi; Edward E Korshin; Poonsakdi Ploypradith; JN Cumming; Suji Xie; Theresa A Shapiro; Gary H Posner
Synthesis and in vitro antimalarial activity of sulfone endoperoxides.
Bioorganic & medicinal chemistry letters 1998;8(8):903-8.
1998: Sara Peleg; C Nguyen; Benjamin T Woodard; J K Lee; Gary H Posner
Differential use of transcription activation function 2 domain of the vitamin D receptor by 1,25-dihydroxyvitamin D3 and its A ring-modified analogs.
Molecular endocrinology (Baltimore, Md.) 1998;12(4):525-35.
1998: JN Cumming; D Wang; S B Park; Theresa A Shapiro; Gary H Posner
Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin.
Journal of medicinal chemistry 1998;41(6):952-64.
1998: Gary H Posner; JN Cumming; S H Woo; Poonsakdi Ploypradith; Suji Xie; Theresa A Shapiro
Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.
Journal of medicinal chemistry 1998;41(6):940-51.
1997: Gary H Posner; Poonsakdi Ploypradith; W Hapangama; D Wang; JN Cumming; Patrick Dolan; Thomas W Kensler; D Klinedinst; Theresa A Shapiro; Q Y Zheng; C K Murray; L G Pilkington; L R Jayasinghe; J F Bray; R Daughenbaugh
Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.
Bioorganic & medicinal chemistry 1997;5(7):1257-65.
1997: JN Cumming; Poonsakdi Ploypradith; Gary H Posner
Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action.
Advances in pharmacology (San Diego, Calif.) 1997;37():253-97.
1996: Sara Peleg; Y Y Liu; S Reddy; R L Horst; M C White; Gary H Posner
A 20-epi side chain restores growth-regulatory and transcriptional activities of an A ring-modified hybrid analog of 1 alpha, 25-dihydroxyvitamin D3 without increasing its affinity to the vitamin D receptor.
Journal of cellular biochemistry 1996;63(2):149-61.
1995: Gary H Posner; Z Li; M C White; V Vinader; K Takeuchi; Sandra E Guggino; Patrick Dolan; Thomas W Kensler
1 alpha,25-dihydroxyvitamin D3 analogs featuring aromatic and heteroaromatic rings: design, synthesis, and preliminary biological testing.
Journal of medicinal chemistry 1995;38(22):4529-37.
1995: Gary H Posner; D Wang; JN Cumming; C H Oh; A N French; A L Bodley; Theresa A Shapiro
Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.
Journal of medicinal chemistry 1995;38(13):2273-5.
1995: Gary H Posner; D J McGarvey; C H Oh; Nirbhay Kumar; Steven R Meshnick; W Asawamahasadka
Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin.
Journal of medicinal chemistry 1995;38(4):607-12.
1994: S Yukihiro; Gary H Posner; Sandra E Guggino
Vitamin D3 analogs stimulate calcium currents in rat osteosarcoma cells.
The Journal of biological chemistry 1994;269(39):23889-93.
1994: Gary H Posner; C H Oh; D Wang; Lucia Gerena; Wilbur K Milhous; Steven R Meshnick; W Asawamahasadka
Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity.
Journal of medicinal chemistry 1994;37(9):1256-8.
1994: Y Zhang; Thomas W Kensler; C G Cho; Gary H Posner; Paul Talalay
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3147-50.
1994: Gary H Posner; C H Oh; Horace Webster; Arba Ager; RN Rossan
New, antimalarial, tricyclic 1,2,4-trioxanes: evaluations in mice and monkeys.
The American journal of tropical medicine and hygiene 1994;50(4):522-6.
1994: Gary H Posner; C G Cho; J V Green; Y Zhang; Paul Talalay
Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes.
Journal of medicinal chemistry 1994;37(1):170-6.
1992: Gary H Posner; T D Nelson; K Z Guyton; Thomas W Kensler
New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs.
Journal of medicinal chemistry 1992;35(17):3280-7.
1992: Y Zhang; C G Cho; Gary H Posner; Paul Talalay
Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols.
Analytical biochemistry 1992;205(1):100-7.
1992: Gary H Posner; C H Oh; Lucia Gerena; Wilbur K Milhous
Extraordinarily potent antimalarial compounds: new, structurally simple, easily synthesized, tricyclic 1,2,4-trioxanes.
Journal of medicinal chemistry 1992;35(13):2459-67.
1992: Y Zhang; Paul Talalay; C G Cho; Gary H Posner
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2399-403.