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Lars Bertram

Research Profile

Disorders

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Byron C Wallace; Lars Bertram; Carla E Brodley; Joshua T Cohen; Joseph Lau; Christina M Lill; Christopher H Schmid; Kevin Small; Thomas A Trikalinos
Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining.
Peter J Castaldi; Michael H Cho; Matthew Cohn; Fawn Langerman; Sienna Moran; Nestor Tarragona; Hala Moukhachen; Radhika Venugopal; Delvina Hasimja; Esther Kao; Byron Wallace; Craig Hersh; Sachin Bagade; Lars Bertram; Edwin K Silverman; Thomas A Trikalinos
The COPD genetic association compendium: a comprehensive online database of COPD genetic associations.
David Fardo; K David Becker; Lars Bertram; Rudolph E Tanzi; Christoph Lange
Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium.

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All Publications

2012: Byron C Wallace; Lars Bertram; Carla E Brodley; Joshua T Cohen; Joseph Lau; Christina M Lill; Christopher H Schmid; Kevin Small; Thomas A Trikalinos
Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining.
Genetics in medicine : official journal of the American College of Medical Genetics 2012;14(7):663-9.
2010: Peter J Castaldi; Michael H Cho; Matthew Cohn; Fawn Langerman; Sienna Moran; Nestor Tarragona; Hala Moukhachen; Radhika Venugopal; Delvina Hasimja; Esther Kao; Byron Wallace; Craig Hersh; Sachin Bagade; Lars Bertram; Edwin K Silverman; Thomas A Trikalinos
The COPD genetic association compendium: a comprehensive online database of COPD genetic associations.
Human molecular genetics 2010;19(3):526-34.
2009: David Fardo; K David Becker; Lars Bertram; Rudolph E Tanzi; Christoph Lange
Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium.
European journal of human genetics : EJHG 2009;17(12):1676-82.
2009: Alice Lu; Mikko Hiltunen; Donna M Romano; Hilkka Soininen; Bradley T Hyman; Lars Bertram; Rudolph E Tanzi
Effects of ubiquilin 1 on the unfolded protein response.
Journal of molecular neuroscience : MN 2009;38(1):19-30.
2009: Brit-Maren M Schjeide; Basavaraj Hooli; Michele Parkinson; Meghan F Hogan; Jason DiVito; Kristina Mullin; Deborah Blacker; Rudolph E Tanzi; Lars Bertram
GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results.
Archives of neurology 2009;66(2):250-4.
2009: Brit-Maren M Schjeide; Matthew B McQueen; Kristina Mullin; Jason DiVito; Meghan F Hogan; Michele Parkinson; Basavaraj Hooli; Christoph Lange; Deborah Blacker; Rudolph E Tanzi; Lars Bertram
Assessment of Alzheimer's disease case-control associations using family-based methods.
Neurogenetics 2009;10(1):19-25.
2008: Lars Bertram; Christoph Lange; Kristina Mullin; Michele Parkinson; Monica Hsiao; Meghan F Hogan; Brit M M Schjeide; Basavaraj Hooli; Jason Divito; Iuliana Ionita; Hongyu Jiang; Nan M Laird; Thomas Moscarillo; Kari L Ohlsen; Kathryn Elliott; Xin Wang; Diane Hu-Lince; Marie Ryder; Amy Murphy; Steven L Wagner; Deborah Blacker; K David Becker; Rudolph E Tanzi
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
American journal of human genetics 2008;83(5):623-32.
2008: Lars Bertram; Rudolph E Tanzi
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.
Nature reviews. Neuroscience 2008;9(10):768-78.
2008: Lars Bertram
Genetic research in schizophrenia: new tools and future perspectives.
Schizophrenia bulletin 2008;34(5):806-12.
2008: Nicole C Allen; Sachin Bagade; Matthew B McQueen; John Ioannidis; Fotini K Kavvoura; Muin J Khoury; Rudolph E Tanzi; Lars Bertram
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Nature genetics 2008;40(7):827-34.
2008: Lars Bertram
The genetics of Alzheimer's disease.
Handbook of clinical neurology 2008;89():223-32.
2007: Matthew B McQueen; Lars Bertram; Christoph Lange; K David Becker; Marilyn S Albert; Rudolph E Tanzi; Deborah Blacker
Exploring candidate gene associations with neuropsychological performance.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(8):987-91.
2007: Marian Hamshere; Peter Holmans; Dimitrios Avramopoulos; Susan S Bassett; Deborah Blacker; Lars Bertram; Howard Wiener; Nan Rochberg; Rudolph E Tanzi; Amanda Myers; Fabienne Wavrant-De Vrièze; Rodney Go; Daniele Fallin; Simon Lovestone; John Hardy; Alison Goate; Michael O'Donovan; Julie Williams; Michael J Owen
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease.
Human molecular genetics 2007;16(22):2703-12.
2007: Saila Vepsäläinen; Michele Parkinson; Seppo Helisalmi; Arto Mannermaa; Hilkka Soininen; Rudolph E Tanzi; Lars Bertram; Mikko Hiltunen
Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.
Journal of medical genetics 2007;44(9):606-8.
2007: Minji Kim; Louis B Hersh; Malcolm Leissring; Martin Ingelsson; Toshifumi Matsui; Wesley Farris; Alice Lu; Bradley T Hyman; Dennis J Selkoe; Lars Bertram; Rudolph E Tanzi
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry 2007;282(11):7825-32.
2007: Rodney T Perry; Howard Wiener; Lindy E Harrell; Deborah Blacker; Rudolph E Tanzi; Lars Bertram; Susan S Bassett; Rodney C P Go
Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(2):220-7.
2007: Lars Bertram; Kristina Mullin; Michele Parkinson; Monica Hsiao; Thomas J Moscarillo; Steven L Wagner; K David Becker; Gonul Velicelebi; Deborah Blacker; Rudolph E Tanzi
Is alpha-T catenin (VR22) an Alzheimer's disease risk gene?
Journal of medical genetics 2007;44(1):e63.
2007: Lars Bertram; Matthew B McQueen; Kristina Mullin; Deborah Blacker; Rudolph E Tanzi
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
Nature genetics 2007;39(1):17-23.
2007: Lars Bertram; Monica Hsiao; Matthew B McQueen; Michele Parkinson; Kristina Mullin; Deborah Blacker; Rudolph E Tanzi
The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data.
Neurobiology of aging 2007;28(1):18.e1-4.
2006: Mikko Hiltunen; Alice Lu; Anne V Thomas; Donna M Romano; Minji Kim; Phill B Jones; Zhongcong Xie; Maria Z Kounnas; Steven L Wagner; Oksana Berezovska; Bradley T Hyman; Giuseppina Tesco; Lars Bertram; Rudolph E Tanzi
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
The Journal of biological chemistry 2006;281(43):32240-53.
2006: Lars Bertram; Monica Hsiao; Christoph Lange; Deborah Blacker; Rudolph E Tanzi
Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples.
American journal of human genetics 2006;79(1):180-3; author reply 183-4.
2006: Hongyu Jiang; David Harrington; Benjamin A Raby; Lars Bertram; Deborah Blacker; Scott Weiss; Christoph Lange
Family-based association test for time-to-onset data with time-dependent differences between the hazard functions.
Genetic epidemiology 2006;30(2):124-32.
2005: Lars Bertram; Michele Parkinson; Matthew B McQueen; Kristina Mullin; Monica Hsiao; Rashmi Menon; Thomas J Moscarillo; Deborah Blacker; Rudolph E Tanzi
Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families.
Journal of medical genetics 2005;42(11):857-62.
2005: Bradford C Dickerson; David H Salat; Douglas N Greve; Elizabeth F Chua; Erin Rand-Giovannetti; Dorene M Rentz; Lars Bertram; Kristina Mullin; Rudolph E Tanzi; Deborah Blacker; Marilyn S Albert; Reisa Sperling
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD.
Neurology 2005;65(3):404-11.
2005: Lars Bertram; Rudolph E Tanzi
The genetic epidemiology of neurodegenerative disease.
The Journal of clinical investigation 2005;115(6):1449-57.
2005: Lars Bertram; M Hsiao; Kristina Mullin; M Parkinson; R Menon; Thomas J Moscarillo; Deborah Blacker; Rudolph E Tanzi
ACAT1 is not associated with Alzheimer's disease in two independent family-based samples.
Molecular psychiatry 2005;10(6):522-4.
2005: Lars Bertram; Mikko Hiltunen; Michele Parkinson; Martin Ingelsson; Christoph Lange; Karunya Ramasamy; Kristina Mullin; Rashmi Menon; Andrew J Sampson; Monica Hsiao; Kathryn J Elliott; Gonul Velicelebi; Thomas J Moscarillo; Bradley T Hyman; Steven L Wagner; K David Becker; Deborah Blacker; Rudolph E Tanzi
Family-based association between Alzheimer's disease and variants in UBQLN1.
The New England journal of medicine 2005;352(9):884-94.
2005: Rudolph E Tanzi; Lars Bertram
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.
Cell 2005;120(4):545-55.
2004: Lars Bertram; Rudolph E Tanzi
The current status of Alzheimer's disease genetics: what do we tell the patients?
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;50(4):385-96.
2004: Lars Bertram; Michele Parkinson; Kristina Mullin; Rashmi Menon; Deborah Blacker; Rudolph E Tanzi
No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample.
Journal of medical genetics 2004;41(4):286-8.
2004: Wesley Farris; Stefan Mansourian; Malcolm Leissring; Elizabeth A Eckman; Lars Bertram; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
The American journal of pathology 2004;164(4):1425-34.
2004: Lars Bertram; Rudolph E Tanzi
Alzheimer's disease: one disorder, too many genes?
Human molecular genetics 2004;13 Spec No 1():R135-41.
2004: Lars Bertram; Rashmi Menon; Kristina Mullin; Michele Parkinson; M L Bradley; Deborah Blacker; Rudolph E Tanzi
PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample.
Neurology 2004;62(2):304-6.
2003: Aleister J Saunders; Lars Bertram; Kristina Mullin; Andrew J Sampson; Khushal Latifzai; Sanjay Basu; Jennifer Jones; Devon Kinney; Laura MacKenzie-Ingano; Stephen Yu; Marilyn S Albert; Thomas J Moscarillo; Rodney C P Go; Susan S Bassett; Mark J Daly; Nan M Laird; Xin Wang; Gonul Velicelebi; Steven L Wagner; David K Becker; Rudolph E Tanzi; Deborah Blacker
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.
Human molecular genetics 2003;12(21):2765-76.
2003: Lars Bertram; Aleister J Saunders; Kristina Mullin; A Sampson; Thomas J Moscarillo; S S Basset; Rodney C P Go; Deborah Blacker; Rudolph E Tanzi
No association between marker D10S1423 and Alzheimer's disease.
Molecular psychiatry 2003;8(6):571-3.
2003: Matthew B McQueen; Lars Bertram; Eric B Rimm; Deborah Blacker; Susan L Santangelo
A QTL genome scan of the metabolic syndrome and its component traits.
BMC genetics 2003;4 Suppl 1():S96.
2003: Deborah Blacker; Lars Bertram; Aleister J Saunders; Thomas J Moscarillo; Marilyn S Albert; Howard Wiener; Rodney T Perry; Julianne Collins; Lindy E Harrell; Rodney C P Go; Amy Mahoney; Terri H beaty; MARGARET D FALLIN; Dimitrios Avramopoulos; Gary A Chase; MARSHAL FOLSTEIN; Melvin G McInnis; Susan S Bassett; Kimberly J Doheny; Elizabeth W Pugh; Rudolph E Tanzi
Results of a high-resolution genome screen of 437 Alzheimer's disease families.
Human molecular genetics 2003;12(1):23-32.
2001: Rudolph E Tanzi; Lars Bertram
New frontiers in Alzheimer's disease genetics.
Neuron 2001;32(2):181-4.
2001: Lars Bertram; Rudolph E Tanzi
Dancing in the dark? The status of late-onset Alzheimer's disease genetics.
Journal of molecular neuroscience : MN 2001;17(2):127-36.
2001: Lars Bertram; Rudolph E Tanzi
Of replications and refutations: the status of Alzheimer's disease genetic research.
Current neurology and neuroscience reports 2001;1(5):442-50.
2001: Lars Bertram; Brooke Hayward; S L Lake; Kathleen Falls; P Van Erdewegh; Deborah Blacker
Family-based tests of association in the presence and absence of known linkage.
Genetic epidemiology 2001;21 Suppl 1():S292-7.
2001: Lars Bertram; Suzanne Y Guénette; Jennifer Jones; D Keeney; Kristina Mullin; A Crystal; Sanjay Basu; S Yhu; A Deng; G. William Rebeck; Bradley T Hyman; Rodney Go; Melvin G McInnis; Deborah Blacker; Rudolph E Tanzi
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.
Annals of neurology 2001;49(1):114-6.
2000: Lars Bertram; Deborah Blacker; Kristina Mullin; D Keeney; Jennifer Jones; Sanjay Basu; S Yhu; Melvin G McInnis; Rodney C P Go; K Vekrellis; Dennis J Selkoe; Aleister J Saunders; Rudolph E Tanzi
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.
Science (New York, N.Y.) 2000;290(5500):2302-3.
2000: Suzanne Y Guénette; Lars Bertram; A Crystal; B Bakondi; Bradley T Hyman; G. William Rebeck; Rudolph E Tanzi; Deborah Blacker
Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients.
Neuroscience letters 2000;296(1):17-20.
2000: Lars Bertram; Deborah Blacker; A Crystal; Kristina Mullin; D Keeney; Jennifer Jones; Sanjay Basu; S Yhu; Suzanne Y Guénette; Melvin G McInnis; Rodney Go; Rudolph E Tanzi
Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies.
Experimental gerontology 2000;35(9-10):1353-61.