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Edward Postlethwait

Research Profile

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Jeffrey D Brand; Michelle V Fanucchi; Lisa M Schwiebert; Katherine L Tuggle; Carol A Ballinger; Edward M Postlethwait
Site-specific dynamics of CD11b+ and CD103+ dendritic cell accumulations following ozone exposure.
Andreas Bracher; Stephen F Doran; Edward M Postlethwait; Giuseppe L Squadrito; Larry Bowen; Sadis Matalon
Targeted aerosolized delivery of ascorbate in the lungs of chlorine-exposed rats.
Andrey A Samal; Giuseppe Squadrito; Chad Steele; Edward M Postlethwait; Kelley M Bradley; Angela Brandon; Stephen Doran; Chad Dunaway; Michelle V Fanucchi; Jaideep Honavar; Yanping Liu; Sadis Matalon; Rakesh P Patel
Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality.

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All Publications

2012: Jeffrey D Brand; Michelle V Fanucchi; Lisa M Schwiebert; Katherine L Tuggle; Carol A Ballinger; Edward M Postlethwait
Site-specific dynamics of CD11b+ and CD103+ dendritic cell accumulations following ozone exposure.
American journal of physiology. Lung cellular and molecular physiology 2012;303(12):L1079-86.
2012: Andreas Bracher; Stephen F Doran; Edward M Postlethwait; Giuseppe L Squadrito; Larry Bowen; Sadis Matalon
Targeted aerosolized delivery of ascorbate in the lungs of chlorine-exposed rats.
Journal of aerosol medicine and pulmonary drug delivery 2012;25(6):333-41.
2012: Andrey A Samal; Giuseppe Squadrito; Chad Steele; Edward M Postlethwait; Kelley M Bradley; Angela Brandon; Stephen Doran; Chad Dunaway; Michelle V Fanucchi; Jaideep Honavar; Yanping Liu; Sadis Matalon; Rakesh P Patel
Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality.
Free radical biology & medicine 2012;53(7):1431-9.
2012: Margaret A Adgent; Carol A Ballinger; David M Krzywanski; Jack R Lancaster; Giuseppe Squadrito; Edward M Postlethwait
Desferrioxamine inhibits protein tyrosine nitration: mechanisms and implications.
Free radical biology & medicine 2012;53(4):951-61.
2012: Rui-Ming Liu; Qiana L Matthews; Praveen K Vayalil; Suqing Wang; Carol A Ballinger; Dale A Dickinson; Wen-Tan Huang; Terrance J Kavanagh; Edward M Postlethwait
Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model.
Free radical biology & medicine 2012;53(3):554-63.
2012: Richard A Corley; Timothy Cox; James P Carson; Michelle V Fanucchi; Robb Glenny; Richard E Jacob; Senthil Kabilan; Andrew P Kuprat; Richard F Larson; Kevin R Minard; Sudhakar Pipavath; Edward M Postlethwait; Charles Timchalk; Christopher D Wallis; Daniel R Einstein
Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human.
Toxicological sciences : an official journal of the Society of Toxicology 2012;128(2):500-16.
2012: Moni Blazej Neradilek; Nayak L Polissar; Edward M Postlethwait; James P Carson; Timothy C Cox; Daniel R Einstein; Robb W Glenny; Richard E Jacob; Xiangmin Jiao; Kevin R Minard; Richard A Corley
Branch-based model for the diameters of the pulmonary airways: accounting for departures from self-consistency and registration errors.
Anatomical record (Hoboken, N.J. : 2007) 2012;295(6):1027-44.
2012: Asaf Stein; Jeannette E Doeller; Michelle V Fanucchi; David W Kraus; Zhengkuan Mao; Joanna P Morrison; Rakesh P Patel; Edward M Postlethwait; Shannon M Bailey
Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2012;112(10):1659-69.
2012: Michelle V Fanucchi; Solana Fernandez; Larry Bowen; Andreas Bracher; Stephen F Doran; Edward M Postlethwait; Giuseppe Squadrito; Sadis Matalon
Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation.
American journal of respiratory cell and molecular biology 2012;46(5):599-606.
2012: Henroy P Scarlett; Elizabeth Delzell; Edward M Postlethwait; Nalini Sathiakumar; R Kent Oestenstad
Asbestos in public hospitals: are employees at risk?
Journal of environmental health 2012;74(6):22-6.
2011: Jaideep Honavar; Akhil Maheshwari; Sadis Matalon; Krishnan MohanKumar; Joann Balanay; Kelley M Bradley; Angela Brandon; Edward M Postlethwait; Andrey A Samal; Giuseppe Squadrito; Rakesh P Patel
Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling.
American journal of respiratory cell and molecular biology 2011;45(2):419-25.
2011: Sotirios G Zarogiannis; Edward M Postlethwait; Giuseppe Squadrito; Amit K Yadav; Larry Bowen; Stephen F Doran; Solana Fernandez; Asta Jurkuvenaite; Sadis Matalon
Ascorbate and deferoxamine administration after chlorine exposure decrease mortality and lung injury in mice.
American journal of respiratory cell and molecular biology 2011;45(2):386-92.
2011: Ashwini Katre; Dae-Kee Kim; Hasina Akhter; Carol A Ballinger; Michelle V Fanucchi; Edward M Postlethwait; Rui-Ming Liu
Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in mice.
Inhalation toxicology 2011;23(8):486-94.
2011: Amit K Yadav; Stephen F Doran; Andrey A Samal; Ruchita Sharma; Kokilavani Vedagiri; Edward M Postlethwait; Giuseppe Squadrito; Michelle V Fanucchi; L Jackson Roberts; Rakesh P Patel; Sadis Matalon
Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite.
American journal of physiology. Lung cellular and molecular physiology 2011;300(3):L362-9.
2011: Kinjal Maniar-Hew; Edward M Postlethwait; Michelle V Fanucchi; Carol A Ballinger; Michael J Evans; Jack R Harkema; Stephan A Carey; Ruth J Mcdonald; Alfred A Bartolucci; Lisa A Miller
Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge.
American journal of physiology. Lung cellular and molecular physiology 2011;300(3):L462-71.
2011: Stephan A Carey; Carol A Ballinger; Charles G Plopper; Ruth J Mcdonald; Alfred A Bartolucci; Edward M Postlethwait; Jack R Harkema
Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys.
American journal of physiology. Lung cellular and molecular physiology 2011;300(2):L242-54.
2010: H P Scarlett; Nalini Sathiakumar; Elizabeth Delzell; R Kent Oestenstad; Edward M Postlethwait
Exposure to airborne asbestos in Jamaican hospitals.
The West Indian medical journal 2010;59(6):668-73.
2010: Giuseppe Squadrito; Edward M Postlethwait; Sadis Matalon
Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications.
American journal of physiology. Lung cellular and molecular physiology 2010;299(3):L289-300.
2010: Amit K Yadav; Andreas Bracher; Stephen F Doran; Martin Leustik; Giuseppe Squadrito; Edward M Postlethwait; Sadis Matalon
Mechanisms and modification of chlorine-induced lung injury in animals.
Proceedings of the American Thoracic Society 2010;7(4):278-83.
2010: Yung Sung Cheng; Larry Bowen; Roy J Rando; Edward M Postlethwait; Giuseppe Squadrito; Sadis Matalon
Exposing animals to oxidant gases: nose only vs. whole body.
Proceedings of the American Thoracic Society 2010;7(4):264-8.
2010: Rui-Ming Liu; Jinah Choi; Jian-He Wu; Kimberly A Gaston Pravia; Karen M Lewis; Jeffrey D Brand; N S Reyes Mochel; David M Krzywanski; J David Lambeth; James Hagood; Henry Jay Forman; Victor J Thannickal; Edward M Postlethwait
Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts.
The Journal of biological chemistry 2010;285(21):16239-47.
2009: Giuseppe Squadrito; Edward M Postlethwait
On the hydrophobicity of nitrogen dioxide: could there be a "lens" effect for NO(2) reaction kinetics?
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2009;21(2):104-9.
2009: gin chuang; Zhen Yang; David G Westbrook; MELISSA POMPILIUS; Carol A Ballinger; C Roger White; David M Krzywanski; Edward M Postlethwait; Scott W Ballinger
Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis.
American journal of physiology. Lung cellular and molecular physiology 2009;297(2):L209-16.
2008: Martin Leustik; Stephen Doran; Andreas Bracher; Shawn Williams; Giuseppe Squadrito; Trenton R Schoeb; Edward M Postlethwait; Sadis Matalon
Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants.
American journal of physiology. Lung cellular and molecular physiology 2008;295(5):L733-43.
2007: James S Brown; Judith A Graham; Lung Chi Chen; Edward M Postlethwait; Andrew J Ghio; W Michael Foster; Terry Gordon
Panel discussion review: session four--assessing biological plausibility of epidemiological findings in air pollution research.
Journal of exposure science & environmental epidemiology 2007;17 Suppl 2():S97-105.
2007: Praveen K Vayalil; Karen E Iles; Jinah Choi; Ae-Kyung Yi; Edward M Postlethwait; Rui-Ming Liu
Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter.
American journal of physiology. Lung cellular and molecular physiology 2007;293(5):L1281-92.
2007: Edward M Postlethwait
Scavenger receptors clear the air.
The Journal of clinical investigation 2007;117(3):601-4.
2007: Stephan A Carey; Kevin R Minard; Lynn L Trease; James G Wagner; Guilherme J M Garcia; Carol A Ballinger; Julia Kimbell; Charles G Plopper; Richard A Corley; Edward M Postlethwait; Jack R Harkema; Daniel R Einstein
Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques.
Toxicologic pathology 2007;35(1):27-40.
2006: Hongqiao Zhang; Honglei Liu; Dale A Dickinson; Rui-Ming Liu; Edward M Postlethwait; Yannick Laperche; Henry Jay Forman
gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells.
Free radical biology & medicine 2006;40(8):1281-92.
2006: Hongqiao Zhang; Honglei Liu; Karen E Iles; Rui-Ming Liu; Edward M Postlethwait; Yannick Laperche; Henry Jay Forman
4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.
American journal of respiratory cell and molecular biology 2006;34(2):174-81.
2005: Praveen K Vayalil; Mitchell A Olman; Joanne E Murphy-Ullrich; Edward M Postlethwait; Rui-Ming Liu
Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen.
American journal of physiology. Lung cellular and molecular physiology 2005;289(6):L937-45.
2005: Carol A Ballinger; Rafael Cueto; Giuseppe Squadrito; Jennifer F Coffin; Leonard W Velsor; William A Pryor; Edward M Postlethwait
Antioxidant-mediated augmentation of ozone-induced membrane oxidation.
Free radical biology & medicine 2005;38(4):515-26.
2004: Zhen Yang; Cynthia A Knight; Madonna M Mamerow; Kasey Vickers; Arthur Penn; Edward M Postlethwait; Scott W Ballinger
Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apolipoprotein E-/- mice fed a chow diet.
Circulation 2004;110(24):3715-20.
2004: Lydia M Connor; Carol A Ballinger; Thomas B Albrecht; Edward M Postlethwait
Interfacial phospholipids inhibit ozone-reactive absorption-mediated cytotoxicity in vitro.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1169-78.
2003: Leonard W Velsor; Carol A Ballinger; Jawaharlal Patel; Edward M Postlethwait
Influence of epithelial lining fluid lipids on NO(2)-induced membrane oxidation and nitration.
Free radical biology & medicine 2003;34(6):720-33.
2003: Jeffrey K Wickliffe; Marinel M Ammenheuser; James J Salazar; Sherif Z Abdel-Rahman; Darlene A Hastings-Smith; Edward M Postlethwait; R Stephen Lloyd; Jonathan B Ward
A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene.
Environmental and molecular mutagenesis 2003;42(2):106-10.
2002: Lidia Michalec; Barun K Choudhury; Edward M Postlethwait; James S Wild; Rafeul Alam; Michael Lett-Brown; Sanjiv Sur
CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):846-52.
2001: L M Connor; Akhil Bidani; Jon Goerke; John A Clements; Edward M Postlethwait
NO2 interfacial transfer is reduced by phospholipid monolayers.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(5):2024-34.
2000: Jesse P Joad; John M Bric; Alison J Weir; Lei F Putney; Dallas M Hyde; Edward M Postlethwait; Charles G Plopper
Effect of respiratory pattern on ozone injury to the airways of isolated rat lungs.
Toxicology and applied pharmacology 2000;169(1):26-32.
2000: Edward M Postlethwait; Jesse P Joad; Dallas M Hyde; Edward S Schelegle; John M Bric; Alison J Weir; Lei F Putney; Viviana J Wong; Leonard W Velsor; Charles G Plopper
Three-dimensional mapping of ozone-induced acute cytotoxicity in tracheobronchial airways of isolated perfused rat lung.
American journal of respiratory cell and molecular biology 2000;22(2):191-9.
1999: Jianliang Zhang; Leonard W Velsor; Jawaharlal M Patel; Edward M Postlethwait; Edward R Block
Nitric oxide-induced reduction of lung cell and whole lung thioredoxin expression is regulated by NF-kappaB.
The American journal of physiology 1999;277(4 Pt 1):L787-93.
1998: Edward M Postlethwait; Rafael Cueto; Leonard W Velsor; W A Pryor
O3-induced formation of bioactive lipids: estimated surface concentrations and lining layer effects.
The American journal of physiology 1998;274(6 Pt 1):L1006-16.
1997: Leonard W Velsor; Edward M Postlethwait
NO2-induced generation of extracellular reactive oxygen is mediated by epithelial lining layer antioxidants.
The American journal of physiology 1997;273(6 Pt 1):L1265-75.
1995: Edward M Postlethwait; Shannon D Langford; L M Jacobson; Akhil Bidani
NO2 reactive absorption substrates in rat pulmonary surface lining fluids.
Free radical biology & medicine 1995;19(5):553-63.
1995: Shannon D Langford; Akhil Bidani; Edward M Postlethwait
Ozone-reactive absorption by pulmonary epithelial lining fluid constituents.
Toxicology and applied pharmacology 1995;132(1):122-30.
1994: Edward M Postlethwait; Akhil Bidani
Mechanisms of pulmonary NO2 absorption.
Toxicology 1994;89(3):217-37.
1994: Edward M Postlethwait; Shannon D Langford; Akhil Bidani
Determinants of inhaled ozone absorption in isolated rat lungs.
Toxicology and applied pharmacology 1994;125(1):77-89.
1993: Nabil M Elsayed; J M Nakashima; Edward M Postlethwait
Measurement of uric acid as a marker of oxygen tension in the lung.
Archives of biochemistry and biophysics 1993;302(1):228-32.
1992: Edward M Postlethwait; Shannon D Langford; Akhil Bidani
Kinetics of NO2 air space absorption in isolated rat lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(5):1939-45.
1991: Edward M Postlethwait; Shannon D Langford; Akhil Bidani
Interfacial transfer kinetics of NO2 into pulmonary epithelial lining fluid.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(4):1502-10.
1991: Edward M Postlethwait; Shannon D Langford; Akhil Bidani
Transfer of NO2 through pulmonary epithelial lining fluid.
Toxicology and applied pharmacology 1991;109(3):464-71.
1990: Edward M Postlethwait; Akhil Bidani; M J Evans
The effect of NO2 exposure on perfusate distribution in isolated rat lungs: pulmonary versus bronchial circulation.
Toxicology and applied pharmacology 1990;106(3):456-61.
1990: Edward M Postlethwait; Shannon D Langford; Akhil Bidani
Reactive absorption of nitrogen dioxide by pulmonary epithelial lining fluid.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(2):523-31.
1990: Edward M Postlethwait; Akhil Bidani
Reactive uptake governs the pulmonary air space removal of inhaled nitrogen dioxide.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(2):594-603.
1989: Edward M Postlethwait; Akhil Bidani
Pulmonary disposition of inhaled NO2-nitrogen in isolated rat lungs.
Toxicology and applied pharmacology 1989;98(2):303-12.
1989: Edward M Postlethwait; M G Mustafa
Effect of altered dose rate on NO2 uptake and transformation in isolated lungs.
Journal of toxicology and environmental health 1989;26(4):497-507.
1988: J M Cheek; Edward M Postlethwait; Edward D Crandall
Effects of culture conditions on susceptibility of alveolar epithelial cell monolayers to NO2.
Toxicology letters 1988;40(3):247-55.
1987: Edward D Crandall; J M Cheek; M E Shaw; Edward M Postlethwait
Effects of nitrogen dioxide on alveolar epithelial barrier properties.
Research report (Health Effects Institute) 1987;(13):3-19.
1987: J M Cheek; Edward M Postlethwait; M E Shaw; Edward D Crandall
Effects of exposure to NO2 on dome formation in alveolar epithelial cell monolayers.
Environmental research 1987;42(1):1-11.
1985: J R Froines; Edward M Postlethwait; E J LaFuente; W C Liu
In vivo and in vitro release of cyanide from neurotoxic aminonitriles.
Journal of toxicology and environmental health 1985;16(3-4):449-60.
1984: M G Mustafa; Nabil M Elsayed; F M von Dohlen; C M Hassett; Edward M Postlethwait; C L Quinn; J A Graham; D E Gardner
A comparison of biochemical effects of nitrogen dioxide, ozone, and their combination in mouse lung.
Toxicology and applied pharmacology 1984;72(1):82-90.
1983: Edward M Postlethwait; M G Mustafa
Formation of N-nitrosomorpholine in isolated rat lungs during nitrogen dioxide ventilation.
Carcinogenesis 1983;4(6):777-8.
1982: M G Mustafa; Nabil M Elsayed; C L Quinn; Edward M Postlethwait; D E Gardner; J A Graham
Comparison of pulmonary biochemical effects of low-level ozone exposure on mice and rats.
Journal of toxicology and environmental health 1982;9(5-6):857-65.
1982: Nabil M Elsayed; M G Mustafa; Edward M Postlethwait
Age-dependent pulmonary response of rats to ozone exposure.
Journal of toxicology and environmental health 1982;9(5-6):835-48.
1981: Edward M Postlethwait; M G Mustafa
Fate of inhaled nitrogen dioxide in isolated perfused rat lung.
Journal of toxicology and environmental health 1981;7(6):861-72.
1980: Edward M Postlethwait; S L Young
Alteration of rat lung adenine nucleotide content after pulmonary edema.
Lung 1980;158(3):157-64.