Charalabos Pothoulakis

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Margolis Kara Gross; Pothoulakis Charalabos
Serotonin has a critical role in the pathogenesis of experimental colitis.
Kim Ho; Rhee Sang Hoon; Pothoulakis Charalabos; LaMont J Thomas
Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin.
Im Eunok; Choi Yoon Jeong; Pothoulakis Charalabos; Rhee Sang Hoon
Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice.

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All Publications

2009: Margolis Kara Gross; Pothoulakis Charalabos
Serotonin has a critical role in the pathogenesis of experimental colitis.
Gastroenterology 2009;137(5):1562-6.
2009: Kim Ho; Rhee Sang Hoon; Pothoulakis Charalabos; LaMont J Thomas
Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin.
Experimental cell research 2009;315(19):3336-44.
2009: Im Eunok; Choi Yoon Jeong; Pothoulakis Charalabos; Rhee Sang Hoon
Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice.
The Journal of nutrition 2009;139(10):1848-54.
2009: Chandras Christina; Koutmani Yassemi; Kokkotou Efi; Pothoulakis Charalabos; Karalis Katia P
Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes.
Endocrinology 2009;150(10):4606-14.
2009: Chen Xinhua; Fruehauf Johannes; Goldsmith Jeffrey D; Xu Hua; Katchar Kianoosh K; Koon Hon-Wai; Zhao Dezheng; Kokkotou Efi G; Pothoulakis Charalabos; Kelly Ciarán P
Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice.
Gastroenterology 2009;137(3):914-23.
2009: Koon Hon-Wai; Kim You Sun; Xu Hua; Kumar Aatish; Zhao Dezheng; Karagiannides Iordanes; Dobner Paul R; Pothoulakis Charalabos
Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8766-71.
2009: Rhee Sang H; Pothoulakis Charalabos; Mayer Emeran A
Principles and clinical implications of the brain-gut-enteric microbiota axis.
Nature reviews. Gastroenterology & hepatology 2009;6(5):306-14.
2009: Gross Kara; Karagiannides Iordanes; Thomou Thomas; Koon Hon Wai; Bowe Collin; Kim Ho; Giorgadze Nino; Tchkonia Tamara; Pirtskhalava Tamara; Kirkland James L; Pothoulakis Charalabos
Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(5):G1012-9.
2009: Bradesi Sylvie; Svensson Camilla I; Steinauer Joanne; Pothoulakis Charalabos; Yaksh Tony L; Mayer Emeran A
Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress.
Gastroenterology 2009;136(4):1339-48, e1-2.
2008: Koon Hon-Wai; Zhao Dezheng; Xu Hua; Bowe Collin; Moss Alan; Moyer Mary P; Pothoulakis Charalabos
Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis.
The American journal of pathology 2008;173(2):400-10.
2008: Rhee Sang Hoon; Im Eunok; Pothoulakis Charalabos
Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer.
Gastroenterology 2008;135(2):518-28.
2008: Kokkotou Efi; Moss Alan C; Torres Daniel; Karagiannides Iordanes; Cheifetz Adam; Liu Sumei; O'Brien Michael; Maratos-Flier Eleftheria; Pothoulakis Charalabos
Melanin-concentrating hormone as a mediator of intestinal inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10613-8.
2008: Na Xi; Kim Ho; Moyer Mary P; Pothoulakis Charalabos; LaMont J Thomas
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.
Infection and immunity 2008;76(7):2862-71.
2008: Gay Jérôme; Kokkotou Efi; O'Brien Michael; Pothoulakis Charalabos; Karalis Katia P
Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis.
Endocrinology 2008;149(7):3403-9.
2008: Subramaniam Dharmalingam; Ramalingam Satish; May Randal; Dieckgraefe Brian K; Berg Douglas E; Pothoulakis Charalabos; Houchen Courtney W; Wang Timothy C; Anant Shrikant
Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms.
Gastroenterology 2008;134(4):1070-82.
2008: Karagiannides Iordanes; Torres Daniel; Tseng Yu-Hua; Bowe Collin; Carvalho Eugenia; Espinoza Daniel; Pothoulakis Charalabos; Kokkotou Efi
Substance P as a novel anti-obesity target.
Gastroenterology 2008;134(3):747-55.
2008: Kokkotou Efi; Moss Alan C; Michos Athanasios; Espinoza Daniel; Cloud Jeffrey W; Mustafa Nasima; O'Brien Michael; Pothoulakis Charalabos; Kelly Ciarán P
Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters.
Antimicrobial agents and chemotherapy 2008;52(3):1121-6.
2007: Karagiannides Iordanes; Pothoulakis Charalabos
Obesity, innate immunity and gut inflammation.
Current opinion in gastroenterology 2007;23(6):661-6.
2007: Kim Ho; Rhee Sang Hoon; Pothoulakis Charalabos; Lamont J Thomas
Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand.
Gastroenterology 2007;133(3):875-86.
2007: Moss Alan C; Anton Pauline; Savidge Tor; Newman Paul; Cheifetz Adam S; Gay Jerome; Paraschos Sophia; Winter Michael Weinstein; Moyer Mary P; Karalis Katia; Kokkotou Efi; Pothoulakis Charalabos
Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha.
Gut 2007;56(9):1210-7.
2007: Gross Kara J; Pothoulakis Charalabos
Role of neuropeptides in inflammatory bowel disease.
Inflammatory bowel diseases 2007;13(7):918-32.
2007: Cottrell Graeme S; Amadesi Silvia; Pikios Stella; Camerer Eric; Willardsen J Adam; Murphy Brett R; Caughey George H; Wolters Paul J; Coughlin Shaun R; Peterson Anders; Knecht Wolfgang; Pothoulakis Charalabos; Bunnett Nigel W; Grady Eileen F
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Gastroenterology 2007;132(7):2422-37.
2007: Tansky Morris F; Pothoulakis Charalabos; Leeman Susan E
Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10691-6.
2007: Savidge Tor C; Newman Paul; Pothoulakis Charalabos; Ruhl Anne; Neunlist Michel; Bourreille Arnaud; Hurst Roger; Sofroniew Michael V
Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione.
Gastroenterology 2007;132(4):1344-58.
2007: Zhao Dezheng; Zhan Yanai; Zeng Huiyan; Koon Hon Wai; Moyer Mary P; Pothoulakis Charalabos
Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells.
International journal of cancer. Journal international du cancer 2007;120(8):1652-6.
2007: Koon Hon-Wai; Zhao Dezheng; Zhan Yanai; Moyer Mary P; Pothoulakis Charalabos
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):2013-8.
2007: Tchkonia Tamara; Lenburg Marc; Thomou Thomas; Giorgadze Nino; Frampton Garrett; Pirtskhalava Tamar; Cartwright Andrew; Cartwright Mark; Flanagan John; Karagiannides Iordanes; Gerry Norman; Forse R Armour; Tchoukalova Yourka; Jensen Michael D; Pothoulakis Charalabos; Kirkland James L
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E298-307.
2006: Koon Hon Wai; Pothoulakis Charalabos
Immunomodulatory properties of substance P: the gastrointestinal system as a model.
Annals of the New York Academy of Sciences 2006;1088():23-40.
2006: Zhao Dezheng; Pothoulakis Charalabos
Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation.
Peptides 2006;27(10):2434-44.
2006: Kokkotou Efi; Torres Daniel; Moss Alan C; O'Brien Michael; Grigoriadis Dimitri E; Karalis Katia; Pothoulakis Charalabos
Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3355-61.
2006: Chen Xinhua; Kokkotou Efi G; Mustafa Nasima; Bhaskar K Ramakrishnan; Sougioultzis Stavros; O'Brien Michael; Pothoulakis Charalabos; Kelly Ciarán P
Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis.
The Journal of biological chemistry 2006;281(34):24449-54.
2006: Chae Sungwon; Eckmann Lars; Miyamoto Yukiko; Pothoulakis Charalabos; Karin Michael; Kagnoff Martin F
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1214-20.
2006: Rhee Sang Hoon; Kim Ho; Moyer Mary P; Pothoulakis Charalabos
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells.
The Journal of biological chemistry 2006;281(27):18560-8.
2006: Bradesi Sylvie; Kokkotou Efi; Simeonidis Simos; Patierno Simona; Ennes Helena S; Mittal Yash; McRoberts James A; Ohning Gordon; McLean Peter; Marvizon Juan Carlos; Sternini Catia; Pothoulakis Charalabos; Mayer Emeran A
The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats.
Gastroenterology 2006;130(6):1729-42.
2006: Koon Hon-Wai; Zhao Dezheng; Zhan Yanai; Rhee Sang Hoon; Moyer Mary P; Pothoulakis Charalabos
Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):5050-9.
2006: Zhao Dezheng; Zhan Yanai; Zeng Huiyan; Moyer Mary P; Mantzoros Christos S; Pothoulakis Charalabos
Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells.
Journal of cellular biochemistry 2006;97(6):1317-27.
2006: Sougioultzis Stavros; Simeonidis Simos; Bhaskar K Ramakrishnan; Chen Xinhua; Anton Pauline M; Keates Sarah; Pothoulakis Charalabos; Kelly Ciarán P
Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression.
Biochemical and biophysical research communications 2006;343(1):69-76.
2006: Karagiannides Iordanes; Kokkotou Efi; Tansky Morris; Tchkonia Tamara; Giorgadze Nino; O'Brien Michael; Leeman Susan E; Kirkland James L; Pothoulakis Charalabos
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):5207-12.
2006: Gay Jérôme; Kokkotou Efi; O'Brien Michael; Pothoulakis Charalabos; Karalis Katia P
Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines.
Neuroimmunomodulation 2006;13(2):114-21.
2005: Kim Ho; Kokkotou Efi; Na Xi; Rhee Sang Hoon; Moyer Mary P; Pothoulakis Charalabos; Lamont J Thomas
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase.
Gastroenterology 2005;129(6):1875-88.
2005: Rhee Sang Hoon; Im Eunok; Riegler Martin; Kokkotou Efi; O'brien Michael; Pothoulakis Charalabos
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13610-5.
2005: Koon Hon-Wai; Zhao Dezheng; Zhan Yanai; Simeonidis Simos; Moyer Mary P; Pothoulakis Charalabos
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1393-400.
2005: Bradesi Sylvie; Schwetz Ines; Ennes Helena S; Lamy Christophe M R; Ohning Gordon; Fanselow Michael; Pothoulakis Charalabos; McRoberts James A; Mayer Emeran A
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(1):G42-53.
2005: Kim Ho; Rhee Sang Hoon; Kokkotou Efi; Na Xi; Savidge Tor; Moyer Mary P; Pothoulakis Charalabos; LaMont J Thomas
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.
The Journal of biological chemistry 2005;280(22):21237-45.
2005: Zhao Dezheng; Zhan Yanai; Zeng Huiyan; Koon Hon-Wai; Moyer Mary P; Pothoulakis Charalabos
Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha.
Molecular pharmacology 2005;67(6):2025-31.
2005: Na Xi; Zhao Dezheng; Koon Hon Wai; Kim Ho; Husmark Johanna; Moyer Mary P; Pothoulakis Charalabos; LaMont J Thomas
Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes.
Gastroenterology 2005;128(4):1002-11.
2005: Sougioultzis Stavros; Kyne Lorraine; Drudy Denise; Keates Sarah; Maroo Seema; Pothoulakis Charalabos; Giannasca Paul J; Lee Cynthia K; Warny Michel; Monath Thomas P; Kelly Ciarán P
Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea.
Gastroenterology 2005;128(3):764-70.
2004: Anton Pauline M; O'Brien Michael; Kokkotou Efi; Eisenstein Barry; Michaelis Arthur; Rothstein David; Paraschos Sophia; Kelly Ciáran P; Pothoulakis Charalabos
Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters.
Antimicrobial agents and chemotherapy 2004;48(10):3975-9.
2004: Koon Hon-Wai; Zhao Dezheng; Na Xi; Moyer Mary P; Pothoulakis Charalabos
Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes.
The Journal of biological chemistry 2004;279(44):45519-27.
2004: Zhao Dezheng; Zhan Yanai; Koon Hon Wai; Zeng Huiyan; Keates Sarah; Moyer Mary P; Pothoulakis Charalabos
Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells.
The Journal of biological chemistry 2004;279(42):43547-54.
2004: Anton Pauline M; Gay Jerome; Mykoniatis Andreas; Pan Amy; O'Brien Michael; Brown Daniel; Karalis Katia; Pothoulakis Charalabos
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8503-8.
2004: Rhee Sang Hoon; Keates Andrew C; Moyer Mary P; Pothoulakis Charalabos
MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells.
The Journal of biological chemistry 2004;279(24):25179-88.
2003: Stucchi Arthur F; Shebani Khaled O; Leeman Susan E; Wang Chi-Chung; Reed Karen L; Fruin A Brent; Gower Adam C; McClung James P; Andry Christopher D; O'Brien Michael J; Pothoulakis Charalabos; Becker James M
A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(6):G1259-67.
2003: Zhao Dezheng; Pothoulakis Charalabos
Rho GTPases as therapeutic targets for the treatment of inflammatory diseases.
Expert opinion on therapeutic targets 2003;7(5):583-92.
2003: Savidge Tor C; Pan Wei-Hua; Newman Paul; O'brien Michael; Anton Pauline M; Pothoulakis Charalabos
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.
Gastroenterology 2003;125(2):413-20.
2003: Lu Lei; Baldeon Manuel E; Savidge Tor; Pothoulakis Charalabos; Walker W Allan
Development of microbial-human enterocyte interaction: cholera toxin.
Pediatric research 2003;54(2):212-8.
2003: Zhao Dezheng; Kuhnt-Moore Sabina; Zeng Huiyan; Wu Jack S; Moyer Mary P; Pothoulakis Charalabos
Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways.
American journal of physiology. Cell physiology 2003;284(6):C1397-404.
2003: Liu Tom S; Musch Mark W; Sugi Kazunori; Walsh-Reitz Margaret M; Ropeleski Mark J; Hendrickson Barbara A; Pothoulakis Charalabos; Lamont J Thomas; Chang Eugene B
Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction.
American journal of physiology. Cell physiology 2003;284(4):C1073-82.
2003: Mykoniatis Andreas; Anton Pauline M; Wlk Michael; Wang Chi Chung; Ungsunan Linda; Blüher Susann; Venihaki Maria; Simeonidis Simos; Zacks Jeff; Zhao Dezheng; Sougioultzis Stavros; Karalis Katia; Mantzoros Christos; Pothoulakis Charalabos
Leptin mediates Clostridium difficile toxin A-induced enteritis in mice.
Gastroenterology 2003;124(3):683-91.
2003: Simeonidis Simos; Castagliuolo Ignazio; Pan Amy; Liu Jennifer; Wang Chi-Chi; Mykoniatis Andreas; Pasha Asia; Valenick Leyla; Sougioultzis Stavros; Zhao Dezheng; Pothoulakis Charalabos
Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2957-62.
2003: Sougioultzis Stavros; Pothoulakis Charalabos
Bacterial infections: small intestine and colon.
Current opinion in gastroenterology 2003;19(1):23-30.
2002: Zhao Dezheng; Kuhnt-Moore Sabina; Zeng Huiyan; Pan Amy; Wu Jack S; Simeonidis Simos; Moyer Mary P; Pothoulakis Charalabos
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases.
The Biochemical journal 2002;368(Pt 2):665-72.
2002: Wlk Michael; Wang Chi C; Venihaki Maria; Liu Jennifer; Zhao Dezheng; Anton Pauline M; Mykoniatis Andreas; Pan Amy; Zacks Jeff; Karalis Katia; Pothoulakis Charalabos
Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum.
Gastroenterology 2002;123(2):505-15.
2002: Castagliuolo I; Morteau O; Keates A C; Valenick L; Wang C-C; Zacks J; Lu B; Gerard N P; Pothoulakis C
Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor.
British journal of pharmacology 2002;136(2):271-9.
2002: He Dan; Sougioultzis Stavros; Hagen Susan; Liu Jennifer; Keates Sarah; Keates Andrew C; Pothoulakis Charalabos; Lamont J Thomas
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation.
Gastroenterology 2002;122(4):1048-57.
2002: Agarwal Banke; Halmos Balazs; Feoktistov Aleksander S; Protiva Petr; Ramey William G; Chen Ming; Pothoulakis Charalabos; Lamont J Thomas; Holt Peter R
Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells.
Carcinogenesis 2002;23(3):521-8.
2002: Morteau Olivier; Castagliuolo Ignazio; Mykoniatis Andreas; Zacks Jeff; Wlk Michael; Lu Bao; Pothoulakis Charalabos; Gerard Norma P; Gerard Craig
Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice.
Gastroenterology 2002;122(3):725-33.
2002: Chen Ming L; Pothoulakis Charalabos; LaMont J Thomas
Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A.
The Journal of biological chemistry 2002;277(6):4247-54.
2001: Zhao D; Keates A C; Kuhnt-Moore S; Moyer M P; Kelly C P; Pothoulakis C
Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes.
The Journal of biological chemistry 2001;276(48):44464-71.
2001: Kirkwood K S; Bunnett N W; Maa J; Castagliolo I; Liu B; Gerard N; Zacks J; Pothoulakis C; Grady E F
Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(2):G544-51.
2001: Qamar A; Aboudola S; Warny M; Michetti P; Pothoulakis C; LaMont J T; Kelly C P
Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice.
Infection and immunity 2001;69(4):2762-5.
2001: Castagliuolo I; Karalis K; Valenick L; Pasha A; Nikulasson S; Wlk M; Pothoulakis C
Endogenous corticosteroids modulate Clostridium difficile toxin A-induced enteritis in rats.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(4):G539-45.
2001: Pothoulakis C; Lamont J T
Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(2):G178-83.
2000: Pothoulakis C
The role of neuroenteric hormones in intestinal infectious diseases.
Current opinion in gastroenterology 2000;16(6):536-40.
2000: Riegler M; Castagliuolo I; Wang C; Wlk M; Sogukoglu T; Wenzl E; Matthews J B; Pothoulakis C
Neurotensin stimulates Cl(-) secretion in human colonic mucosa In vitro: role of adenosine.
Gastroenterology 2000;119(2):348-57.
2000: Castagliuolo I; Valenick L; Liu J; Pothoulakis C
Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells.
The Journal of biological chemistry 2000;275(34):26545-50.
2000: He D; Hagen S J; Pothoulakis C; Chen M; Medina N D; Warny M; LaMont J T
Clostridium difficile toxin A causes early damage to mitochondria in cultured cells.
Gastroenterology 2000;119(1):139-50.
2000: Warny M; Keates A C; Keates S; Castagliuolo I; Zacks J K; Aboudola S; Qamar A; Pothoulakis C; LaMont J T; Kelly C P
p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis.
The Journal of clinical investigation 2000;105(8):1147-56.
2000: Pothoulakis C
Effects of Clostridium difficile toxins on epithelial cell barrier.
Annals of the New York Academy of Sciences 2000;915():347-56.
1999: Riegler M; Castagliuolo I; Wlk M; Pothoulakis C
Substance P causes a chloride-dependent short-circuit current response in rabbit colonic mucosa in vitro.
Scandinavian journal of gastroenterology 1999;34(12):1203-11.
1999: Riegler M; Castagliuolo I; So P T; Lotz M; Wang C; Wlk M; Sogukoglu T; Cosentini E; Bischof G; Hamilton G; Teleky B; Wenzl E; Matthews J B; Pothoulakis C
Effects of substance P on human colonic mucosa in vitro.
The American journal of physiology 1999;276(6 Pt 1):G1473-83.
1999: Riegler M; Lotz M; Sears C; Pothoulakis C; Castagliuolo I; Wang C C; Sedivy R; Sogukoglu T; Cosentini E; Bischof G; Feil W; Teleky B; Hamilton G; LaMont J T; Wenzl E
Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro.
Gut 1999;44(4):504-10.
1999: Castagliuolo I; Wang C C; Valenick L; Pasha A; Nikulasson S; Carraway R E; Pothoulakis C
Neurotensin is a proinflammatory neuropeptide in colonic inflammation.
The Journal of clinical investigation 1999;103(6):843-9.
1999: Qiu B; Pothoulakis C; Castagliuolo I; Nikulasson S; LaMont J T
Participation of reactive oxygen metabolites in Clostridium difficile toxin A-induced enteritis in rats.
The American journal of physiology 1999;276(2 Pt 1):G485-90.
1999: Warny M; Fatimi A; Bostwick E F; Laine D C; Lebel F; LaMont J T; Pothoulakis C; Kelly C P
Bovine immunoglobulin concentrate-clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine.
Gut 1999;44(2):212-7.
1999: Castagliuolo I; Riegler M F; Valenick L; LaMont J T; Pothoulakis C
Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa.
Infection and immunity 1999;67(1):302-7.
1999: Pothoulakis C
Enterotoxin A of Clostridium difficile and alpha-Gal epitopes.
Sub-cellular biochemistry 1999;32():215-27.
1998: Choi R S; Riegler M; Pothoulakis C; Kim B S; Mooney D; Vacanti M; Vacanti J P
Studies of brush border enzymes, basement membrane components, and electrophysiology of tissue-engineered neointestine.
Journal of pediatric surgery 1998;33(7):991-6; discussion 996-7.
1998: Pothoulakis C; Castagliuolo I; Leeman S E; Wang C C; Li H; Hoffman B J; Mezey E
Substance P receptor expression in intestinal epithelium in clostridium difficile toxin A enteritis in rats.
The American journal of physiology 1998;275(1 Pt 1):G68-75.
1998: Castagliuolo I; Wershil B K; Karalis K; Pasha A; Nikulasson S T; Pothoulakis C
Colonic mucin release in response to immobilization stress is mast cell dependent.
The American journal of physiology 1998;274(6 Pt 1):G1094-1100.
1998: Castagliuolo I; Keates A C; Wang C C; Pasha A; Valenick L; Kelly C P; Nikulasson S T; LaMont J T; Pothoulakis C
Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):6039-45.
1998: Pothoulakis C; Castagliuolo I; Leeman S E
Neuroimmune mechanisms of intestinal responses to stress. Role of corticotropin-releasing factor and neurotensin.
Annals of the New York Academy of Sciences 1998;840():635-48.
1998: Wershil B K; Castagliuolo I; Pothoulakis C
Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice.
Gastroenterology 1998;114(5):956-64.
1998: Castagliuolo I; Riegler M; Pasha A; Nikulasson S; Lu B; Gerard C; Gerard N P; Pothoulakis C
Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis.
The Journal of clinical investigation 1998;101(8):1547-50.
1998: Keates A C; Castagliuolo I; Qiu B; Nikulasson S; Sengupta A; Pothoulakis C
CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A-induced enteritis.
The American journal of physiology 1998;274(1 Pt 1):G196-202.
1997: Linevsky J K; Pothoulakis C; Keates S; Warny M; Keates A C; Lamont J T; Kelly C P
IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes.
The American journal of physiology 1997;273(6 Pt 1):G1333-40.
1997: Riegler M; Sedivy R; Sogukoglu T; Castagliuolo I; Pothoulakis C; Cosentini E; Bischof G; Hamilton G; Teleky B; Feil W; Lamont J T; Wenzl E
Epidermal growth factor attenuates Clostridium difficile toxin A- and B-induced damage of human colonic mucosa.
The American journal of physiology 1997;273(5 Pt 1):G1014-22.
1997: Salcedo J; Keates S; Pothoulakis C; Warny M; Castagliuolo I; LaMont J T; Kelly C P
Intravenous immunoglobulin therapy for severe Clostridium difficile colitis.
Gut 1997;41(3):366-70.
1997: Castagliuolo I; Kelly C P; Qiu B S; Nikulasson S T; LaMont J T; Pothoulakis C
IL-11 inhibits Clostridium difficile toxin A enterotoxicity in rat ileum.
The American journal of physiology 1997;273(2 Pt 1):G333-41.
1997: Castagliuolo I; Keates A C; Qiu B; Kelly C P; Nikulasson S; Leeman S E; Pothoulakis C
Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4788-93.
1997: Kelly C P; Chetham S; Keates S; Bostwick E F; Roush A M; Castagliuolo I; LaMont J T; Pothoulakis C
Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract.
Antimicrobial agents and chemotherapy 1997;41(2):236-41.
1996: Castagliuolo I; LaMont J T; Nikulasson S T; Pothoulakis C
Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum.
Infection and immunity 1996;64(12):5225-32.
1996: Castagliuolo I; Lamont J T; Qiu B; Fleming S M; Bhaskar K R; Nikulasson S T; Kornetsky C; Pothoulakis C
Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells.
The American journal of physiology 1996;271(5 Pt 1):G884-92.
1996: Pothoulakis C
Pathogenesis of Clostridium difficile-associated diarrhoea.
European journal of gastroenterology & hepatology 1996;8(11):1041-7.
1996: Castagliuolo I; Leeman S E; Bartolak-Suki E; Nikulasson S; Qiu B; Carraway R E; Pothoulakis C
A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12611-5.
1996: Pothoulakis C; Gilbert R J; Cladaras C; Castagliuolo I; Semenza G; Hitti Y; Montcrief J S; Linevsky J; Kelly C P; Nikulasson S; Desai H P; Wilkins T D; LaMont J T
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A.
The Journal of clinical investigation 1996;98(3):641-9.
1996: Castagliuolo I; LaMont J T; Qiu B; Nikulasson S T; Pothoulakis C
A receptor decoy inhibits the enterotoxic effects of Clostridium difficile toxin A in rat ileum.
Gastroenterology 1996;111(2):433-8.
1996: Qiu B; Pothoulakis C; Castagliuolo I; Nikulasson Z; LaMont J T
Nitric oxide inhibits rat intestinal secretion by Clostridium difficile toxin A but not Vibrio cholerae enterotoxin.
Gastroenterology 1996;111(2):409-18.
1996: Pothoulakis C; Galili U; Castagliuolo I; Kelly C P; Nikulasson S; Dudeja P K; Brasitus T A; LaMont J T
A human antibody binds to alpha-galactose receptors and mimics the effects of Clostridium difficile toxin A in rat colon.
Gastroenterology 1996;110(6):1704-12.
1996: Kelly C P; Pothoulakis C; Vavva F; Castagliuolo I; Bostwick E F; O'Keane J C; Keates S; LaMont J T
Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins.
Antimicrobial agents and chemotherapy 1996;40(2):373-9.
1995: Burakoff R; Zhao L; Celifarco A J; Rose K L; Donovan V; Pothoulakis C; Percy W H
Effects of purified Clostridium difficile toxin A on rabbit distal colon.
Gastroenterology 1995;109(2):348-54.
1995: Riegler M; Sedivy R; Pothoulakis C; Hamilton G; Zacherl J; Bischof G; Cosentini E; Feil W; Schiessel R; LaMont J T
Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro.
The Journal of clinical investigation 1995;95(5):2004-11.
1994: Kelly C P; Keates S; Siegenberg D; Linevsky J K; Pothoulakis C; Brady H R
IL-8 secretion and neutrophil activation by HT-29 colonic epithelial cells.
The American journal of physiology 1994;267(6 Pt 1):G991-7.
1994: Castagliuolo I; LaMont J T; Letourneau R; Kelly C; O'Keane J C; Jaffer A; Theoharides T C; Pothoulakis C
Neuronal involvement in the intestinal effects of Clostridium difficile toxin A and Vibrio cholerae enterotoxin in rat ileum.
Gastroenterology 1994;107(3):657-65.
1994: Kelly C P; Becker S; Linevsky J K; Joshi M A; O'Keane J C; Dickey B F; LaMont J T; Pothoulakis C
Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit.
The Journal of clinical investigation 1994;93(3):1257-65.
1994: Pothoulakis C; Castagliuolo I; LaMont J T; Jaffer A; O'Keane J C; Snider R M; Leeman S E
CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):947-51.
1994: Kelly C P; Pothoulakis C; LaMont J T
Clostridium difficile colitis.
The New England journal of medicine 1994;330(4):257-62.
1993: Pothoulakis C; LaMont J T
Clostridium difficile colitis and diarrhea.
Gastroenterology clinics of North America 1993;22(3):623-37.
1993: Pothoulakis C; Karmeli F; Kelly C P; Eliakim R; Joshi M A; O'Keane C J; Castagliuolo I; LaMont J T; Rachmilewitz D
Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum.
Gastroenterology 1993;105(3):701-7.
1993: Pothoulakis C; Castagliuolo I; LaMont J T
Diagnostic tests for Clostridium difficile diarrhoea and colitis: past, present and future.
Journal of gastroenterology and hepatology 1993;8(4):311-2.
1993: Pothoulakis C; Kelly C P; Joshi M A; Gao N; O'Keane C J; Castagliuolo I; Lamont J T
Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum.
Gastroenterology 1993;104(4):1108-15.
1992: Eglow R; Pothoulakis C; Itzkowitz S; Israel E J; O'Keane C J; Gong D; Gao N; Xu Y L; Walker W A; LaMont J T
Diminished Clostridium difficile toxin A sensitivity in newborn rabbit ileum is associated with decreased toxin A receptor.
The Journal of clinical investigation 1992;90(3):822-9.
1992: Kelly C P; Pothoulakis C; Orellana J; LaMont J T
Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A-receptor binding.
Gastroenterology 1992;102(1):35-40.
1991: Pothoulakis C; LaMont J T; Eglow R; Gao N; Rubins J B; Theoharides T C; Dickey B F
Characterization of rabbit ileal receptors for Clostridium difficile toxin A. Evidence for a receptor-coupled G protein.
The Journal of clinical investigation 1991;88(1):119-25.
1991: Leung D Y; Kelly C P; Boguniewicz M; Pothoulakis C; LaMont J T; Flores A
Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin.
The Journal of pediatrics 1991;118(4 ( Pt 1)):633-7.
1990: Miller P D; Pothoulakis C; Baeker T R; LaMont J T; Rothstein T L
Macrophage-dependent stimulation of T cell-depleted spleen cells by Clostridium difficile toxin A and calcium ionophore.
Cellular immunology 1990;126(1):155-63.
1989: Triadafilopoulos G; Pothoulakis C; Weiss R; Giampaolo C; Lamont J T
Comparative study of Clostridium difficile toxin A and cholera toxin in rabbit ileum.
Gastroenterology 1989;97(5):1186-92.
1989: Gilbert R J; Pothoulakis C; LaMont J T
Effect of purified Clostridium difficile toxins on intestinal smooth muscle. II. Toxin B.
The American journal of physiology 1989;256(4 Pt 1):G767-72.
1989: Gilbert R J; Triadafilopoulos G; Pothoulakis C; Giampaolo C; LaMont J T
Effect of purified Clostridium difficile toxins on intestinal smooth muscle. I. Toxin A.
The American journal of physiology 1989;256(4 Pt 1):G759-66.
1988: Pothoulakis C; Sullivan R; Melnick D A; Triadafilopoulos G; Gadenne A S; Meshulam T; LaMont J T
Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes.
The Journal of clinical investigation 1988;81(6):1741-5.

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