Barry Potter

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Foster Paul A; Ho Yaik T; Newman Simon P; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.
Liu Qun; Graeff Richard; Kriksunov Irina A; Jiang Hong; Zhang Bo; Oppenheimer Norman; Lin Hening; Potter Barry V L; Lee Hon Cheung; Hao Quan
Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase.
Abbate Sergio; Longhi Giovanna; Castiglioni Ettore; Lebon France; Wood Paul M; Woo Lawrence W L; Potter Barry V L
Determination of the absolute configuration of aromatase and dual aromatase-sulfatase inhibitors by vibrational and electronic circular dichroism spectra analysis.

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All Publications

2009: Foster Paul A; Ho Yaik T; Newman Simon P; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.
Anticancer research 2009;29(10):3751-7.
2009: Liu Qun; Graeff Richard; Kriksunov Irina A; Jiang Hong; Zhang Bo; Oppenheimer Norman; Lin Hening; Potter Barry V L; Lee Hon Cheung; Hao Quan
Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase.
The Journal of biological chemistry 2009;284(40):27637-45.
2009: Abbate Sergio; Longhi Giovanna; Castiglioni Ettore; Lebon France; Wood Paul M; Woo Lawrence W L; Potter Barry V L
Determination of the absolute configuration of aromatase and dual aromatase-sulfatase inhibitors by vibrational and electronic circular dichroism spectra analysis.
Chirality 2009;21(9):802-8.
2009: Rossi Ana M; Riley Andrew M; Tovey Stephen C; Rahman Taufiq; Dellis Olivier; Taylor Emily J A; Veresov Valery G; Potter Barry V L; Taylor Colin W
Synthetic partial agonists reveal key steps in IP3 receptor activation.
Nature chemical biology 2009;5(9):631-9.
2009: Veiga Nicolás; Torres Julia; Godage Himali Y; Riley Andrew M; Domínguez Sixto; Potter Barry V L; Díaz Alvaro; Kremer Carlos
The behaviour of inositol 1,3,4,5,6-pentakisphosphate in the presence of the major biological metal cations.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(7):1001-13.
2009: Kirchberger Tanja; Moreau Christelle; Wagner Gerd K; Fliegert Ralf; Siebrands Cornelia C; Nebel Merle; Schmid Frederike; Harneit Angelika; Odoardi Francesca; Flügel Alexander; Potter Barry V L; Guse Andreas H
8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.
The Biochemical journal 2009;422(1):139-49.
2009: Dammermann Werner; Zhang Bo; Nebel Merle; Cordiglieri Chiara; Odoardi Francesca; Kirchberger Tanja; Kawakami Naoto; Dowden James; Schmid Frederike; Dornmair Klaus; Hohenegger Martin; Flügel Alexander; Guse Andreas H; Potter Barry V L
NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10678-83.
2009: Sureshan Kana M; Riley Andrew M; Rossi Ana M; Tovey Stephen C; Dedos Skarlatos G; Taylor Colin W; Potter Barry V L
Activation of IP(3) receptors by synthetic bisphosphate ligands.
Chemical communications (Cambridge, England) 2009;(10):1204-6.
2009: Day Joanna M; Tutill Helena J; Foster Paul A; Bailey Helen V; Heaton Wesley B; Sharland Christopher M; Vicker Nigel; Potter Barry V L; Purohit Atul; Reed Michael J
Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
Molecular and cellular endocrinology 2009;301(1-2):251-8.
2009: Su Xiangdong; Vicker Nigel; Trusselle Melanie; Halem Heather; Culler Michael D; Potter Barry V L
Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Molecular and cellular endocrinology 2009;301(1-2):169-73.
2009: Vicker Nigel; Sharland Christopher M; Heaton Wesley B; Gonzalez Ana M Ramos; Bailey Helen V; Smith Andrew; Springall Jeremy S; Day Joanna M; Tutill Helena J; Reed Michael J; Purohit Atul; Potter Barry V L
The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.
Molecular and cellular endocrinology 2009;301(1-2):259-65.
2009: Day Joanna M; Purohit Atul; Tutill Helena J; Foster Paul A; Woo L W Lawrence; Potter Barry V L; Reed Michael J
The development of steroid sulfatase inhibitors for hormone-dependent cancer therapy.
Annals of the New York Academy of Sciences 2009;1155():80-7.
2009: Day J M; Foster P A; Tutill H J; Newman S P; Ho Y T; Leese M P; Potter B V L; Reed M J; Purohit A
BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.
British journal of cancer 2009;100(3):476-86.
2008: Jourdan Fabrice; Bubert Christian; Leese Mathew P; Smith Andrew; Ferrandis Eric; Regis-Lydi Sandra; Newman Simon P; Purohit Atul; Reed Michael J; Potter Barry V L
Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling.
Organic & biomolecular chemistry 2008;6(22):4108-19.
2008: Parsons M F C; Foster P A; Chander S K; Jhalli R; Newman S P; Leese M P; Potter B V L; Purohit A; Reed M J
The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer.
British journal of cancer 2008;99(9):1433-41.
2008: Bubert Christian; Woo L W Lawrence; Sutcliffe Oliver B; Mahon Mary F; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile: SAR, crystal structures, in vitro and in vivo activities.
ChemMedChem 2008;3(11):1708-30.
2008: Foster Paul A; Chander Surinder K; Newman Simon P; Woo L W Lawrence; Sutcliffe Oliver B; Bubert Christian; Zhou Dujin; Chen Shiuan; Potter Barry V L; Reed Michael J; Purohit Atul
A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6469-77.
2008: Foster Paul A; Ho Yaik T; Newman Simon P; Kasprzyk Philip G; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique.
Breast cancer research and treatment 2008;111(2):251-60.
2008: Foster Paul A; Chander Surinder K; Parsons Michael F C; Newman Simon P; Woo L W Lawrence; Potter Barry V L; Reed Michael J; Purohit Atul
Efficacy of three potent steroid sulfatase inhibitors: pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer.
Breast cancer research and treatment 2008;111(1):129-38.
2008: Woo L W Lawrence; Fischer Delphine S; Sharland Christopher M; Trusselle Melanie; Foster Paul A; Chander Surinder K; Di Fiore Anna; Supuran Claudiu T; De Simone Giuseppina; Purohit Atul; Reed Michael J; Potter Barry V L
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.
Molecular cancer therapeutics 2008;7(8):2435-44.
2008: Foster Paul A; Woo L W Lawrence; Potter Barry V L; Reed Michael J; Purohit Atul
The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.
Endocrinology 2008;149(8):4035-42.
2008: Wood Paul M; Woo L W Lawrence; Labrosse Jean-Robert; Trusselle Melanie N; Abbate Sergio; Longhi Giovanna; Castiglioni Ettore; Lebon France; Purohit Atul; Reed Michael J; Potter Barry V L
Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.
Journal of medicinal chemistry 2008;51(14):4226-38.
2008: Mills Stephen J; Vandeput Fabrice; Trusselle Melanie N; Safrany Stephen T; Erneux Christophe; Potter Barry V L
Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha.
Chembiochem : a European journal of chemical biology 2008;9(11):1757-66.
2008: Purohit A; Chander S K; Woo L W L; Parsons M F C; Jhalli R; Potter B V L; Reed M J
Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy.
Anticancer research 2008;28(3A):1517-23.
2008: Foster Paul A; Stengel C; Ali Tauhid; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul; Newman Simon P
A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140.
Anticancer research 2008;28(3A):1483-91.
2008: Day Joanna M; Foster Paul A; Tutill Helena J; Parsons Michael F C; Newman Simon P; Chander Surinder K; Allan Gillian M; Lawrence Harshani R; Vicker Nigel; Potter Barry V L; Reed Michael J; Purohit Atul
17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.
International journal of cancer. Journal international du cancer 2008;122(9):1931-40.
2008: Allan Gillian M; Vicker Nigel; Lawrence Harshani R; Tutill Helena J; Day Joanna M; Huchet Marion; Ferrandis Eric; Reed Michael J; Purohit Atul; Potter Barry V L
Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design.
Bioorganic & medicinal chemistry 2008;16(8):4438-56.
2008: Jackson Toby; Woo L W Lawrence; Trusselle Melanie N; Purohit Atul; Reed Michael J; Potter Barry V L
Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling.
ChemMedChem 2008;3(4):603-18.
2008: Foster Paul A; Newman Simon P; Leese Mathew P; Bernetiere Sonia; Diolez Christian; Camara Jose; Hacher Beatrice; Baronnet Marie-Madeleine; Ali Tauhid; Potter Barry V L; Reed Michael J; Purohit Atul
A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer.
Anticancer research 2008;28(2A):577-81.
2008: Zhang Bo; Wagner Gerd K; Weber Karin; Garnham Clive; Morgan Anthony J; Galione Antony; Guse Andreas H; Potter Barry V L
2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.
Journal of medicinal chemistry 2008;51(6):1623-36.
2008: Bojarová Pavla; Denehy Emma; Walker Ian; Loft Karen; De Souza David P; Woo L W Lawrence; Potter Barry V L; McConville Malcolm J; Williams Spencer J
Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates.
Chembiochem : a European journal of chemical biology 2008;9(4):613-23.
2008: Leese Mathew P; Jourdan Fabrice L; Gaukroger Keira; Mahon Mary F; Newman Simon P; Foster Paul A; Stengel Chloe; Regis-Lydi Sandra; Ferrandis Eric; Di Fiore Anna; De Simone Giuseppina; Supuran Claudiu T; Purohit Atul; Reed Michael J; Potter Barry V L
Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
Journal of medicinal chemistry 2008;51(5):1295-308.
2008: Sureshan Kana M; Trusselle Melanie; Tovey Stephen C; Taylor Colin W; Potter Barry V L
2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling.
The Journal of organic chemistry 2008;73(5):1682-92.
2008: Zhang Bo; Bailey Victoria C; Potter Barry V L
Chemoenzymatic synthesis of 7-deaza cyclic adenosine 5'-diphosphate ribose analogues, membrane-permeant modulators of intracellular calcium release.
The Journal of organic chemistry 2008;73(5):1693-703.
2008: Newman Simon P; Foster Paul A; Stengel Chloe; Day Joanna M; Ho Yaik T; Judde Jean-Gabriel; Lassalle Myriam; Prevost Gregoire; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):597-606.
2008: Su Xiangdong; Vicker Nigel; Potter Barry V L
Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Progress in medicinal chemistry 2008;46():29-130.
2007: Newman S P; Foster P A; Ho Y T; Day J M; Raobaikady B; Kasprzyk P G; Leese M P; Potter B V L; Reed M J; Purohit A
The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.
British journal of cancer 2007;97(12):1673-82.
2007: Jackson Toby; Woo L W Lawrence; Trusselle Melanie N; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
Organic & biomolecular chemistry 2007;5(20):2940-52.
2007: Jackson Toby; Woo L W Lawrence; Trusselle Melanie N; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
Organic & biomolecular chemistry 2007;5(18):2940-52.
2007: Bubert Christian; Leese Mathew P; Mahon Mary F; Ferrandis Eric; Regis-Lydi Sandra; Kasprzyk Philip G; Newman Simon P; Ho Yaik T; Purohit Atul; Reed Michael J; Potter Barry V L
3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.
Journal of medicinal chemistry 2007;50(18):4431-43.
2007: Liu Qun; Kriksunov Irina A; Moreau Christelle; Graeff Richard; Potter Barry V L; Lee Hon Cheung; Hao Quan
Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog.
The Journal of biological chemistry 2007;282(34):24825-32.
2007: Woo L W Lawrence; Bubert Christian; Sutcliffe Oliver B; Smith Andrew; Chander Surinder K; Mahon Mary F; Purohit Atul; Reed Michael J; Potter Barry V L
Dual aromatase-steroid sulfatase inhibitors.
Journal of medicinal chemistry 2007;50(15):3540-60.
2007: Su Xiangdong; Vicker Nigel; Lawrence Harshani; Smith Andrew; Purohit Atul; Reed Michael J; Potter Barry V L
Inhibition of human and rat 11beta-hydroxysteroid dehydrogenase type 1 by 18beta-glycyrrhetinic acid derivatives.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):312-20.
2007: Vicker Nigel; Su Xiangdong; Ganeshapillai Dharshini; Smith Andrew; Purohit Atul; Reed Michael J; Potter Barry V L
Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):123-9.
2007: Chander S K; Foster P A; Leese M P; Newman S P; Potter B V L; Purohit A; Reed M J
In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol.
British journal of cancer 2007;96(9):1368-76.
2007: Vandeput Fabrice; Combettes Laurent; Mills Stephen J; Backers Katrien; Wohlkönig Alexandre; Parys Jan B; De Smedt Humbert; Missiaen Ludwig; Dupont Geneviève; Potter Barry V L; Erneux Christophe
Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1481-91.
2007: Stanway Susannah J; Delavault Patrick; Purohit Atul; Woo L W Lawrence; Thurieau Christophe; Potter Barry V L; Reed Michael J
Steroid sulfatase: a new target for the endocrine therapy of breast cancer.
The oncologist 2007;12(4):370-4.
2007: Mills Stephen J; Komander David; Trusselle Melanie N; Safrany Stephen T; van Aalten Daan M F; Potter Barry V L
Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha.
ACS chemical biology 2007;2(4):242-6.
2007: Zhang Bo; Muller-Steffner Hélène; Schuber Francis; Potter Barry V L
Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase.
Biochemistry 2007;46(13):4100-9.
2006: Leese Mathew P; Leblond Bertrand; Smith Andrew; Newman Simon P; Di Fiore Anna; De Simone Giuseppina; Supuran Claudiu T; Purohit Atul; Reed Michael J; Potter Barry V L
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.
Journal of medicinal chemistry 2006;49(26):7683-96.
2006: Mills Stephen J; Dozol Hélène; Vandeput Fabrice; Backers Katrien; Woodman Timothy; Erneux Christophe; Spiess Bernard; Potter Barry V L
3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase: Synthesis and physicochemistry.
Chembiochem : a European journal of chemical biology 2006;7(11):1696-706.
2006: Kirchberger T; Wagner G; Xu J; Cordiglieri C; Wang P; Gasser A; Fliegert R; Bruhn S; Flügel A; Lund F E; Zhang L-H; Potter B V L; Guse A H
Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives.
British journal of pharmacology 2006;149(4):337-44.
2006: Foster Paul A; Newman Simon P; Chander Surinder K; Stengel Chloe; Jhalli Roma; Woo Lawrence L W; Potter Barry V L; Reed Michael J; Purohit Atul
In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5543-9.
2006: Mochizuki Tetsuya; Kondo Yoshihiko; Abe Hiroshi; Tovey Stephen C; Dedos Skarlatos G; Taylor Colin W; Paul Michael; Potter Barry V L; Matsuda Akira; Shuto Satoshi
Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands.
Journal of medicinal chemistry 2006;49(19):5750-8.
2006: Moreau Christelle; Wagner Gerd K; Weber Karin; Guse Andreas H; Potter Barry V L
Structural determinants for N1/N7 cyclization of nicotinamide hypoxanthine 5'-dinucleotide (NHD+) derivatives by ADP-ribosyl cyclase from aplysia californica: Ca2+-mobilizing activity of 8-substituted cyclic inosine 5'-diphosphoribose analogues in T-lymphocytes.
Journal of medicinal chemistry 2006;49(17):5162-76.
2006: Godage Himali Y; Riley Andrew M; Woodman Timothy J; Potter Barry V L
Regioselective hydrolysis of myo-inositol 1,3,5-orthobenzoate via a 1,2-bridged 2'-phenyl-1',3'-dioxolan-2'-ylium ion provides a rapid route to the anticancer agent Ins(1,3,4,5,6)P5.
Chemical communications (Cambridge, England) 2006;(28):2989-91.
2006: Riley Andrew M; Trusselle Melanie; Kuad Paul; Borkovec Michal; Cho Jaiesoon; Choi Jae H; Qian Xun; Shears Stephen B; Spiess Bernard; Potter Barry V L
scyllo-inositol pentakisphosphate as an analogue of myo-inositol 1,3,4,5,6-pentakisphosphate: chemical synthesis, physicochemistry and biological applications.
Chembiochem : a European journal of chemical biology 2006;7(7):1114-22.
2006: Dowden James; Berridge Georgina; Moreau Christelle; Yamasaki Michiko; Churchill Grant C; Potter Barry V L; Galione Antony
Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release.
Chemistry & biology 2006;13(6):659-65.
2006: Sureshan Kana M; Trusselle Melanie; Tovey Stephen C; Taylor Colin W; Potter Barry V L
Guanophostin A: Synthesis and evaluation of a high affinity agonist of the D-myo-inositol 1,4,5-trisphosphate receptor.
Chemical communications (Cambridge, England) 2006;(19):2015-7.
2006: Vicker Nigel; Lawrence Harshani R; Allan Gillian M; Bubert Christian; Smith Andrew; Tutill Helena J; Purohit Atul; Day Joanna M; Mahon Mary F; Reed Michael J; Potter Barry V L
Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
ChemMedChem 2006;1(4):464-81.
2006: Mochizuki Tetsuya; Kondo Yoshihiko; Abe Hiroshi; Taylor Colin W; Potter Barry V L; Matsuda Akira; Shuto Satoshi
Design and synthesis of 5'-deoxy-5'-phenyladenophostin A, a highly potent IP3 receptor ligand.
Organic letters 2006;8(7):1455-8.
2006: Terauchi Masaru; Abe Hiroshi; Tovey Stephen C; Dedos Skarlatos G; Taylor Colin W; Paul Michael; Trusselle Melanie; Potter Barry V L; Matsuda Akira; Shuto Satoshi
A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy.
Journal of medicinal chemistry 2006;49(6):1900-9.
2006: Stanway Susannah J; Purohit Atul; Woo L W Lawrence; Sufi Saulat; Vigushin David; Ward Rebecca; Wilson Richard H; Stanczyk Frank Z; Dobbs Nicola; Kulinskaya Elena; Elliott Moira; Potter Barry V L; Reed Michael J; Coombes R Charles
Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1585-92.
2006: Moreau Christelle; Woodman Timothy J; Potter Barry V L
Unusual entry to the novel 8-halo-N1-ribosyl hypoxanthine system by degradation of a cyclic adenosine-5'-diphosphate ribose analogue.
Chemical communications (Cambridge, England) 2006;(10):1127-9.
2006: Day Joanna M; Tutill Helena J; Newman Simon P; Purohit Atul; Lawrence Harshani R; Vicker Nigel; Potter Barry V L; Reed Michael J
17Beta-hydroxysteroid dehydrogenase Type 1 and Type 2: association between mRNA expression and activity in cell lines.
Molecular and cellular endocrinology 2006;248(1-2):246-9.
2006: Purohit A; Tutill H J; Day J M; Chander S K; Lawrence H R; Allan G M; Fischer D S; Vicker N; Newman S P; Potter B V L; Reed M J
The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer.
Molecular and cellular endocrinology 2006;248(1-2):199-203.
2006: Allan Gillian M; Bubert Christian; Vicker Nigel; Smith Andrew; Tutill Helena J; Purohit Atul; Reed Michael J; Potter Barry V L
Novel, potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Molecular and cellular endocrinology 2006;248(1-2):204-7.
2006: Su Xiangdong; Vicker Nigel; Ganeshapillai Dharshini; Smith Andrew; Purohit Atul; Reed Michael J; Potter Barry V L
Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Molecular and cellular endocrinology 2006;248(1-2):214-7.
2006: Allan Gillian M; Lawrence Harshani R; Cornet Josephine; Bubert Christian; Fischer Delphine S; Vicker Nigel; Smith Andrew; Tutill Helena J; Purohit Atul; Day Joanna M; Mahon Mary F; Reed Michael J; Potter Barry V L
Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Journal of medicinal chemistry 2006;49(4):1325-45.
2006: Newman Simon P; Ireson Christopher R; Tutill Helena J; Day Joanna M; Parsons Michael F C; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.
Cancer research 2006;66(1):324-30.
2006: Riley Andrew M; Deleu Sandrine; Qian Xun; Mitchell Jennifer; Chung Sung-Kee; Adelt Stephan; Vogel Günter; Potter Barry V L; Shears Stephen B
On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate.
FEBS letters 2006;580(1):324-30.
2005: Raobaikady Bindumalini; Reed Michael J; Leese Mathew P; Potter Barry V L; Purohit Atul
Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates.
International journal of cancer. Journal international du cancer 2005;117(1):150-9.
2005: Maffucci Tania; Piccolo Enza; Cumashi Albana; Iezzi Manuela; Riley Andrew M; Saiardi Adolfo; Godage H Yasmin; Rossi Cosmo; Broggini Massimo; Iacobelli Stefano; Potter Barry V L; Innocenti Paolo; Falasca Marco
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects.
Cancer research 2005;65(18):8339-49.
2005: Fischer Delphine S; Allan Gillian M; Bubert Christian; Vicker Nigel; Smith Andrew; Tutill Helena J; Purohit Atul; Wood Lynn; Packham Graham; Mahon Mary F; Reed Michael J; Potter Barry V L
E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Journal of medicinal chemistry 2005;48(18):5749-70.
2005: Leese Mathew P; Hejaz Hatem A M; Mahon Mary F; Newman Simon P; Purohit Atul; Reed Michael J; Potter Barry V L
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
Journal of medicinal chemistry 2005;48(16):5243-56.
2005: Poinas Alexandra; Backers Katrien; Riley Andrew M; Mills Stephen J; Moreau Colette; Potter Barry V L; Erneux Christophe
Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues.
Chembiochem : a European journal of chemical biology 2005;6(8):1449-57.
2005: Laude Alex J; Tovey Stephen C; Dedos Skarlatos G; Potter Barry V L; Lummis Sarah C R; Taylor Colin W
Rapid functional assays of recombinant IP3 receptors.
Cell calcium 2005;38(1):45-51.
2005: Kudoh Takashi; Fukuoka Masayoshi; Ichikawa Satoshi; Murayama Takashi; Ogawa Yasuo; Hashii Minako; Higashida Haruhiro; Kunerth Svenja; Weber Karin; Guse Andreas H; Potter Barry V L; Matsuda Akira; Shuto Satoshi
Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety.
Journal of the American Chemical Society 2005;127(24):8846-55.
2005: Wagner Gerd K; Guse Andreas H; Potter Barry V L
Rapid synthetic route toward structurally modified derivatives of cyclic adenosine 5'-diphosphate ribose.
The Journal of organic chemistry 2005;70(12):4810-9.
2005: Lloyd Matthew D; Thiyagarajan Nethaji; Ho Yaik T; Woo L W Lawrence; Sutcliffe Oliver B; Purohit Atul; Reed Michael J; Acharya K Ravi; Potter Barry V L
First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.
Biochemistry 2005;44(18):6858-66.
2005: Lawrence Harshani R; Vicker Nigel; Allan Gillian M; Smith Andrew; Mahon Mary F; Tutill Helena J; Purohit Atul; Reed Michael J; Potter Barry V L
Novel and potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Journal of medicinal chemistry 2005;48(8):2759-62.
2005: Reed M J; Purohit A; Woo L W L; Newman S P; Potter B V L
Steroid sulfatase: molecular biology, regulation, and inhibition.
Endocrine reviews 2005;26(2):171-202.
2005: Leese Mathew P; Leblond Bertrand; Newman Simon P; Purohit Atul; Reed Michael J; Potter Barry V L
Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3-O-sulfamates.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):239-51.
2005: Raobaikady B; Day J M; Purohit A; Potter B V L; Reed M J
The nature of inhibition of steroid sulphatase activity by tibolone and its metabolites.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):229-37.
2005: Utsumi T; Leese M P; Chander S K; Gaukroger K; Purohit A; Newman S P; Potter B V L; Reed M J
The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):219-27.
2005: Purohit A; Ghilchik M W; Leese M P; Potter B V L; Reed M J
Regulation of aromatase activity by cytokines, PGE2 and 2-methoxyoestrone-3-O-sulphamate in fibroblasts derived from normal and malignant breast tissues.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):167-72.
2005: Wood Paul M; Woo L W Lawrence; Humphreys Anna; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
A letrozole-based dual aromatase-sulphatase inhibitor with in vivo activity.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):123-30.
2005: Lloyd Matthew D; Pederick Richard L; Natesh Ramanathan; Woo L W Lawrence; Purohit Atul; Reed Michael J; Acharya K Ravi; Potter Barry V L
Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.
The Biochemical journal 2005;385(Pt 3):715-20.
2005: Borissow Charles N; Black Steven J; Paul Michael; Tovey Stephen C; Dedos Skarlatos G; Taylor Colin W; Potter Barry V L
Adenophostin A and analogues modified at the adenine moiety: synthesis, conformational analysis and biological activity.
Organic & biomolecular chemistry 2005;3(2):245-52.
2005: Dowden James; Brown Richard S; Moreau Christelle; Galione Antony; Potter Barry V L
Chemical synthesis of the novel Ca2+ messenger NAADP.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):513-8.
2004: Ireson C R; Chander S K; Purohit A; Parish D C; Woo L W L; Potter B V L; Reed M J
Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats.
British journal of cancer 2004;91(7):1399-404.
2004: Solyakov Lev; Cain Kelvin; Tracey Beryl M; Jukes Rebekah; Riley Andrew M; Potter Barry V L; Tobin Andrew B
Regulation of casein kinase-2 (CK2) activity by inositol phosphates.
The Journal of biological chemistry 2004;279(42):43403-10.
2004: Dowden James; Moreau Christelle; Brown Richard S; Berridge Georgina; Galione Antony; Potter Barry V L
Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate.
Angewandte Chemie (International ed. in English) 2004;43(35):4637-40.
2004: Chander Surinder K; Purohit Atul; Woo L W Lawrence; Potter Barry V L; Reed Michael J
The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates.
Biochemical and biophysical research communications 2004;322(1):217-22.
2004: Su Xiangdong; Lawrence Harshani; Ganeshapillai Dharshini; Cruttenden Adrian; Purohit Atul; Reed Michael J; Vicker Nigel; Potter Barry V L
Novel 18beta-glycyrrhetinic acid analogues as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenases.
Bioorganic & medicinal chemistry 2004;12(16):4439-57.
2004: Horne Graeme; Maechling Clarisse; Fleig Andrea; Hirata Masato; Penner Reinhold; Spiess Bernard; Potter Barry V L
D-6-Deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, a mimic of d-myo-inositol 1,3,4,5-tetrakisphosphate: biological activity and pH-dependent conformational properties.
Biochemical and biophysical research communications 2004;320(4):1262-70.
2004: Gregory Roland B; Hughes Rachael; Riley Andrew M; Potter Barry V L; Wilcox Robert A; Barritt Greg J
Inositol trisphosphate analogues selective for types I and II inositol trisphosphate receptors exert differential effects on vasopressin-stimulated Ca2+ inflow and Ca2+ release from intracellular stores in rat hepatocytes.
The Biochemical journal 2004;381(Pt 2):519-26.
2004: Vicker Nigel; Su Xiangdong; Lawrence Harshani; Cruttenden Adrian; Purohit Atul; Reed Michael J; Potter Barry V L
A novel 18 beta-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11 beta-hydroxysteroid dehydrogenase 2.
Bioorganic & medicinal chemistry letters 2004;14(12):3263-7.
2004: Leese Mathew P; Newman Simon P; Purohit Atul; Reed Michael J; Potter Barry V L
2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents.
Bioorganic & medicinal chemistry letters 2004;14(12):3135-8.
2004: Wood L; Leese M P; Mouzakiti A; Purohit A; Potter B V L; Reed M J; Packham G
2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases.
Apoptosis : an international journal on programmed cell death 2004;9(3):323-32.
2004: Riley Andrew M; Dozol Helene; Spiess Bernard; Potter Barry V L
2-O-(2-Aminoethyl)-myo-inositol 1,4,5-trisphosphate as a novel ligand for conjugation: physicochemical properties and synthesis of a new Ins(1,4,5)P(3) affinity matrix.
Biochemical and biophysical research communications 2004;318(2):444-52.
2004: Hejaz Hatem A M; Woo L W Lawrence; Purohit Atul; Reed Michael J; Potter Barry V L
Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase.
Bioorganic & medicinal chemistry 2004;12(10):2759-72.
2004: Potter Barry V L; Walseth Timothy F
Medicinal chemistry and pharmacology of cyclic ADP-ribose.
Current molecular medicine 2004;4(3):303-11.
2004: Kunerth Svenja; Langhorst Matthias F; Schwarzmann Nadine; Gu Xianfeng; Huang Lijun; Yang Zhenjun; Zhang Liangren; Mills Steven J; Zhang Li-He; Potter Barry V L; Guse Andreas H
Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells.
Journal of cell science 2004;117(Pt 10):2141-9.
2004: Reed Julie E; Woo L W Lawrence; Robinson James J; Leblond Bertrand; Leese Mathew P; Purohit Atul; Reed Michael J; Potter Barry V L
2-difluoromethyloestrone 3-O-sulphamate, a highly potent steroid sulphatase inhibitor.
Biochemical and biophysical research communications 2004;317(1):169-75.
2004: Newman Simon P; Leese Mathew P; Purohit Atul; James David R C; Rennie Catherine E; Potter Barry V L; Reed Michael J
Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates.
International journal of cancer. Journal international du cancer 2004;109(4):533-40.
2004: Riley Andrew M; Laude Alex J; Taylor Colin W; Potter Barry V L
Dimers of D-myo-inositol 1,4,5-trisphosphate: design, synthesis, and interaction with Ins(1,4,5)P3 receptors.
Bioconjugate chemistry 2004;15(2):278-89.
2004: Piccolo Enza; Vignati Sara; Maffucci Tania; Innominato Pasquale F; Riley Andrew M; Potter Barry V L; Pandolfi Pier Paolo; Broggini Massimo; Iacobelli Stefano; Innocenti Paolo; Falasca Marco
Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway.
Oncogene 2004;23(9):1754-65.
2004: Ireson C R; Chander S K; Purohit A; Perera S; Newman S P; Parish D; Leese M P; Smith A C; Potter B V L; Reed M J
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.
British journal of cancer 2004;90(4):932-7.
2004: Mort Christopher J W; Migaud Marie E; Galione Antony; Potter Barry V L
Aplysia californica mediated cyclisation of novel 3'-modified NAD+ analogues: a role for hydrogen bonding in the recognition of cyclic adenosine 5'-diphosphate ribose.
Bioorganic & medicinal chemistry 2004;12(2):475-87.
2004: Abbate Francesco; Winum Jean-Yves; Potter Barry V L; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.
Bioorganic & medicinal chemistry letters 2004;14(1):231-4.
2004: Horne Graeme; Mills Stephen J; Potter Barry V L
First derivatives of myo-inositol 1,4,6-trisphosphate modified at positions 2 and 3: structural analogues of D-myo-inositol 1,4,5-trisphosphate.
Carbohydrate research 2004;339(1):51-65.
2003: Mills Stephen J; Riley Andrew M; Liu Changsheng; Mahon Mary F; Potter Barry V L
A definitive synthesis of D-myo-inositol 1,4,5,6-tetrakisphosphate and its enantiomer D-myo-inositol 3,4,5,6-tetrakisphosphate from a novel butane-2,3-diacetal-protected inositol.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(24):6207-14.
2003: Rosenberg Heidi J; Riley Andrew M; Laude Alex J; Taylor Colin W; Potter Barry V L
Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction.
Journal of medicinal chemistry 2003;46(23):4860-71.
2003: Mills Stephen J; Backers Katrien; Erneux Christophe; Potter Barry V L
Synthesis of D- and L-myo-inositol 1,2,4,6-tetrakisphosphate, regioisomers of myo-inositol 1,3,4,5 tetrakisphosphate: activity against Ins(1,4,5)P3 binding proteins.
Organic & biomolecular chemistry 2003;1(20):3546-56.
2003: Shuto Satoshi; Fukuoka Masayoshi; Kudoh Takashi; Garnham Clive; Galione Antony; Potter Barry V L; Matsuda Akira
Convergent synthesis and unexpected Ca(2+)-mobilizing activity of 8-substituted analogues of cyclic ADP-carbocyclic-ribose, a stable mimic of the Ca(2+)-mobilizing second messenger cyclic ADP-ribose.
Journal of medicinal chemistry 2003;46(22):4741-9.
2003: Whitley Paul; Reaves Barbara J; Hashimoto Makoto; Riley Andrew M; Potter Barry V L; Holman Geoffrey D
Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.
The Journal of biological chemistry 2003;278(40):38786-95.
2003: Purohit A; Woo L W L; Chander S K; Newman S P; Ireson C; Ho Y; Grasso A; Leese M P; Potter B V L; Reed M J
Steroid sulphatase inhibitors for breast cancer therapy.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):423-32.
2003: Mills Stephen J; Potter Barry V L
Synthesis of potent Ins(1,4,5)P3 5-phosphatase inhibitors by modification of myo-inositol 1,3,4,6-tetrakisphosphate.
Bioorganic & medicinal chemistry 2003;11(19):4245-53.
2003: Ho Y T; Newman S P; Purohit A; Leese M P; Potter B V L; Reed M J
The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-alpha on endothelial and fibroblast cell growth, morphology and apoptosis.
The Journal of steroid biochemistry and molecular biology 2003;86(2):189-96.
2003: Wagner Gerd K; Black Steven; Guse Andreas H; Potter Barry V L
First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist.
Chemical communications (Cambridge, England) 2003;(15):1944-5.
2003: Woo L W Lawrence; Sutcliffe Oliver B; Bubert Christian; Grasso Anna; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
First dual aromatase-steroid sulfatase inhibitors.
Journal of medicinal chemistry 2003;46(15):3193-6.
2003: Ho Y T; Purohit A; Vicker N; Newman S P; Robinson J J; Leese M P; Ganeshapillai D; Woo L W L; Potter B V L; Reed M J
Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates.
Biochemical and biophysical research communications 2003;305(4):909-14.
2003: Fischer Delphine S; Woo L W Lawrence; Mahon Mary F; Purohit Atul; Reed Michael J; Potter Barry V L
D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase.
Bioorganic & medicinal chemistry 2003;11(8):1685-700.
2003: Vicker Nigel; Ho Yaikat; Robinson James; Woo Lawrence L W; Purohit Atul; Reed Michael J; Potter Barry V L
Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.
Bioorganic & medicinal chemistry letters 2003;13(5):863-5.
2003: Raobaikady Bindumalini; Purohit Atul; Chander Surinder K; Woo L W Lawrence; Leese Mathew P; Potter Barry V L; Reed Michael J
Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):351-8.
2003: Fischer Delphine S; Chander Surinder K; Woo L W Lawrence; Fenton Janine C; Purohit Atul; Reed Michael J; Potter Barry V L
Novel D-ring modified steroid derivatives as potent, non-estrogenic, steroid sulfatase inhibitors with in vivo activity.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):343-9.
2003: Ireson Christopher R; Parish David; Purohit Atul; Woo Lawrence W L; Potter Barry V L; Chander Surinder K; Reed Michael J
Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):337-42.
2003: Day Joanna M; Newman Simon P; Comninos Alexander; Solomon Claire; Purohit Atul; Leese Matthew P; Potter Barry V L; Reed Michael J
The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):317-25.
2003: Suzuki R N; Newman S P; Purohit A; Leese M P; Potter B V L; Reed M J
Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):269-78.
2003: Wagner Gerd K; Riley Andrew M; Rosenberg Heidi J; Taylor Colin W; Guse Andreas H; Potter Barry V L
Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction.
Nucleic acids research. Supplement (2001) 2003;(3):1-2.
2002: Howarth Nicola M; Purohit Atul; Robinson James J; Vicker Nigel; Reed Michael J; Potter Barry V L
Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: homology model construction and docking studies.
Biochemistry 2002;41(50):14801-14.
2002: Mills Stephen J; Liu Changsheng; Potter Barry V L
Synthesis of D- and L-myo-inositol 2,4,5-trisphosphate and trisphosphorothioate: structural analogues of D-myo-inositol 1,4,5-trisphosphate.
Carbohydrate research 2002;337(20):1795-801.
2002: Riley Andrew M; Morris Stephen A; Nerou Edmund P; Correa Vanessa; Potter Barry V L; Taylor Colin W
Interactions of inositol 1,4,5-trisphosphate (IP(3)) receptors with synthetic poly(ethylene glycol)-linked dimers of IP(3) suggest close spacing of the IP(3)-binding sites.
The Journal of biological chemistry 2002;277(43):40290-5.
2002: Morris Stephen A; Nerou Edmund P; Riley Andrew M; Potter Barry V L; Taylor Colin W
Determinants of adenophostin A binding to inositol trisphosphate receptors.
The Biochemical journal 2002;367(Pt 1):113-20.
2002: Riley Andrew M; Jenkins David J; Marwood Rachel D; Potter Barry V L
Synthesis of glucopyranoside-based ligands for D-myo-inositol 1,4,5-trisphosphate receptors.
Carbohydrate research 2002;337(12):1067-82.
2002: Guse Andreas H; Cakir-Kiefer Céline; Fukuoka Masayoshi; Shuto Satoshi; Weber Karin; Bailey Victoria C; Matsuda Akira; Mayr Georg W; Oppenheimer Norman; Schuber Francis; Potter Barry V L
Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.
Biochemistry 2002;41(21):6744-51.
2002: Ho Melisa W Y; Yang Xiaonian; Carew Mark A; Zhang Tong; Hua Len; Kwon Yong-Uk; Chung Sung-Kee; Adelt Stephan; Vogel Günter; Riley Andrew M; Potter Barry V L; Shears Stephen B
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.
Current biology : CB 2002;12(6):477-82.
2002: Parekh Anant B; Riley Andrew M; Potter Barry V L
Adenophostin A and ribophostin, but not inositol 1,4,5-trisphosphate or manno-adenophostin, activate the Ca2+ release-activated Ca2+ current, I(CRAC), in weak intracellular Ca2+ buffer.
The Biochemical journal 2002;361(Pt 1):133-41.
2001: Schöttelndreier H; Potter B V; Mayr G W; Guse A H
Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling.
Cellular signalling 2001;13(12):895-9.
2001: Shuto S; Horne G; Marwood R D; Potter B V
Total synthesis of nucleobase-modified adenophostin A mimics.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(22):4937-46.
2001: Liu C; Riley A M; Yang X; Shears S B; Potter B V
Synthesis and biological activity of D- and L-chiro-inositol 2,3,4,5-tetrakisphosphate: design of a novel and potent inhibitor of Ins(3,4,5,6)P4 1-kinase/Ins(1,3,4)P3 5/6-kinase.
Journal of medicinal chemistry 2001;44(18):2984-9.
2001: Riley A M; Correa V; Mahon M F; Taylor C W; Potter B V
Bicyclic analogues of D-myo-inositol 1,4,5-trisphosphate related to adenophostin A: synthesis and biological activity.
Journal of medicinal chemistry 2001;44(13):2108-17.
2001: Correa V; Riley A M; Shuto S; Horne G; Nerou E P; Marwood R D; Potter B V; Taylor C W
Structural determinants of adenophostin A activity at inositol trisphosphate receptors.
Molecular pharmacology 2001;59(5):1206-15.
2001: Nerou E P; Riley A M; Potter B V; Taylor C W
Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor.
The Biochemical journal 2001;355(Pt 1):59-69.
2001: Horne G; Potter B V
Synthesis of the enantiomers of 6-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, structural analogues of myo-inositol 1,3,4,5-tetrakisphosphate.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(1):80-7.
2001: Purohit A; Woo L W; Barrow D; Hejaz H A; Nicholson R I; Potter B V; Reed M J
Non-steroidal and steroidal sulfamates: new drugs for cancer therapy.
Molecular and cellular endocrinology 2001;171(1-2):129-35.
2000: Newman S P; Purohit A; Ghilchik M W; Potter B V; Reed M J
Regulation of steroid sulphatase expression and activity in breast cancer.
The Journal of steroid biochemistry and molecular biology 2000;75(4-5):259-64.
2000: Malini B; Purohit A; Ganeshapillai D; Woo L W; Potter B V; Reed M J
Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates.
The Journal of steroid biochemistry and molecular biology 2000;75(4-5):253-8.
2000: Bonser J; Walker J; Purohit A; Reed M J; Potter B V; Willis D S; Franks S; Mason H D
Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production.
The Journal of endocrinology 2000;167(3):465-71.
2000: Adkins C E; Wissing F; Potter B V; Taylor C W
Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A.
The Biochemical journal 2000;352 Pt 3():929-33.
2000: Marwood R D; Jenkins D J; Correa V; Taylor C W; Potter B V
Contribution of the adenine base to the activity of adenophostin A investigated using a base replacement strategy.
Journal of medicinal chemistry 2000;43(22):4278-87.
2000: Rosenberg H J; Riley A M; Correa V; Taylor C W; Potter B V
C-glycoside based mimics of D-myo-inositol 1,4,5-trisphosphate.
Carbohydrate research 2000;329(1):7-16.
2000: Woo L L; Purohit A; Malini B; Reed M J; Potter B V
Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates.
Chemistry & biology 2000;7(10):773-91.
2000: Berg I; Potter B V; Mayr G W; Guse A H
Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling.
The Journal of cell biology 2000;150(3):581-8.
2000: Purohit A; Woo L W; Potter B V; Reed M J
In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE.
Cancer research 2000;60(13):3394-6.
2000: Murphy C T; Riley A M; Mills S J; Lindley C J; Potter B V; Westwick J
myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3, 6-trisphosphorothioate: partial agonists with very low intrinsic activity at the platelet myo-inositol 1,4,5-trisphosphate receptor.
Molecular pharmacology 2000;57(3):595-601.
2000: Singh A; Purohit A; Hejaz H A; Potter B V; Reed M J
Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate.
Molecular and cellular endocrinology 2000;160(1-2):61-6.
2000: Purohit A; Hejaz H A; Walden L; MacCarthy-Morrogh L; Packham G; Potter B V; Reed M J
The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours.
International journal of cancer. Journal international du cancer 2000;85(4):584-9.
1999: Felemez M; Marwood R D; Potter B V; Spiess B
Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate.
Biochemical and biophysical research communications 1999;266(2):334-40.
1999: Hohenegger M; Berg I; Weigl L; Mayr G W; Potter B V; Guse A H
Pharmacological activation of the ryanodine receptor in Jurkat T-lymphocytes.
British journal of pharmacology 1999;128(6):1235-40.
1999: Reyes-Harde M; Potter B V; Galione A; Stanton P K
Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores.
Journal of neurophysiology 1999;82(3):1569-76.
1999: Hejaz H A; Purohit A; Mahon M F; Reed M J; Potter B V
Synthesis and biological activity of the superestrogen (E)-17-oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: x-ray crystal structure of (E)-17-oximino-3-hydroxy-1,3,5(10)-estratriene.
Journal of medicinal chemistry 1999;42(16):3188-92.
1999: Migaud M E; Pederick R L; Bailey V C; Potter B V
Probing Aplysia californica adenosine 5'-diphosphate ribosyl cyclase for substrate binding requirements: design of potent inhibitors.
Biochemistry 1999;38(28):9105-14.
1999: Yang X; Rudolf M; Carew M A; Yoshida M; Nerreter V; Riley A M; Chung S K; Bruzik K S; Potter B V; Schultz C; Shears S B
Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate.
The Journal of biological chemistry 1999;274(27):18973-80.
1999: Rakovic S; Cui Y; Iino S; Galione A; Ashamu G A; Potter B V; Terrar D A
An antagonist of cADP-ribose inhibits arrhythmogenic oscillations of intracellular Ca2+ in heart cells.
The Journal of biological chemistry 1999;274(25):17820-7.
1999: Liu C; Davis R J; Nahorski S R; Ballereau S; Spiess B; Potter B V
Synthesis, calcium mobilizing, and physicochemical properties of D-chiro-inositol 1,3,4,6-tetrakisphosphate, a novel and potent ligand at the D-myo-inositol 1,4,5-trisphosphate receptor.
Journal of medicinal chemistry 1999;42(11):1991-8.
1999: Surdo P L; Bottomley M J; Arcaro A; Siegal G; Panayotou G; Sankar A; Gaffney P R; Riley A M; Potter B V; Waterfield M D; Driscoll P C
Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates.
The Journal of biological chemistry 1999;274(22):15678-85.
1999: Purohit A; Hejaz H A; Woo L W; van Strien A E; Potter B V; Reed M J
Recent advances in the development of steroid sulphatase inhibitors.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):227-38.
1999: Baraldi E; Djinovic Carugo K; Hyvönen M; Surdo P L; Riley A M; Potter B V; O'Brien R; Ladbury J E; Saraste M
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.
Structure (London, England : 1993) 1999;7(4):449-60.
1999: Hirst P H; Riley A M; Mills S J; Spiers I D; Poyner D R; Freeman S; Potter B V; Smith A W
Inositol polyphosphate-mediated iron transport in Pseudomonas aeruginosa.
Journal of applied microbiology 1999;86(3):537-43.
1999: Reyes-Harde M; Empson R; Potter B V; Galione A; Stanton P K
Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):4061-6.
1999: Guse A H; da Silva C P; Berg I; Skapenko A L; Weber K; Heyer P; Hohenegger M; Ashamu G A; Schulze-Koops H; Potter B V; Mayr G W
Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose.
Nature 1999;398(6722):70-3.
1999: Marwood R D; Riley A M; Correa V; Taylor C W; Potter B V
Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate.
Bioorganic & medicinal chemistry letters 1999;9(3):453-8.
1999: Beecroft M D; Marchant J S; Riley A M; Van Straten N C; Van der Marel G A; Van Boom J H; Potter B V; Taylor C W
Acyclophostin: a ribose-modified analog of adenophostin A with high affinity for inositol 1,4,5-trisphosphate receptors and pH-dependent efficacy.
Molecular pharmacology 1999;55(1):109-17.
1998: da Silva C P; Potter B V; Mayr G W; Guse A H
Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1998;707(1-2):43-50.
1998: Purohit A; Vernon K A; Hummelinck A E; Woo L W; Hejaz H A; Potter B V; Reed M J
The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatase inhibitors with reduced oestrogenicity.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):269-75.
1998: Woo L W; Howarth N M; Purohit A; Hejaz H A; Reed M J; Potter B V
Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase.
Journal of medicinal chemistry 1998;41(7):1068-83.
1998: Purohit A; Potter B V; Parker M G; Reed M J
Steroid sulphatase: expression, isolation and inhibition for active-site identification studies.
Chemico-biological interactions 1998;109(1-3):183-93.
1997: Liu C; Potter B V
Synthesis of 3-Position-Modified Analogues of myo-Inositol 1,4,5-Trisphosphate, Tools for Investigation of the Polyphosphoinositide Pathway of Cellular Signaling.
The Journal of organic chemistry 1997;62(24):8335-40.
1997: Hirata M; Takeuchi H; Riley A M; Mills S J; Watanabe Y; Potter B V
Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate.
The Biochemical journal 1997;328 ( Pt 1)():93-8.
1997: Murphy C T; Riley A M; Lindley C J; Jenkins D J; Westwick J; Potter B V
Structural analogues of D-myo-inositol-1,4,5-trisphosphate and adenophostin A: recognition by cerebellar and platelet inositol-1,4,5-trisphosphate receptors.
Molecular pharmacology 1997;52(4):741-8.
1997: Marchant J S; Beecroft M D; Riley A M; Jenkins D J; Marwood R D; Taylor C W; Potter B V
Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors.
Biochemistry 1997;36(42):12780-90.
1997: Ashamu G A; Sethi J K; Galione A; Potter B V
Roles for adenosine ribose hydroxyl groups in cyclic adenosine 5'-diphosphate ribose-mediated Ca2+ release.
Biochemistry 1997;36(31):9509-17.
1997: Sethi J K; Empson R M; Bailey V C; Potter B V; Galione A
7-Deaza-8-bromo-cyclic ADP-ribose, the first membrane-permeant, hydrolysis-resistant cyclic ADP-ribose antagonist.
The Journal of biological chemistry 1997;272(26):16358-63.
1997: Purohit A; Froome V A; Wang D Y; Potter B V; Reed M J
Measurement of oestrone sulphatase activity in white blood cells to monitor in vivo inhibition of steroid sulphatase activity by oestrone-3-O-sulphamate.
The Journal of steroid biochemistry and molecular biology 1997;62(1):45-51.
1997: Guse A H; da Silva C P; Weber K; Armah C N; Ashamu G A; Schulze C; Potter B V; Mayr G W; Hilz H
1-(5-phospho-beta-D-ribosyl)2'-phosphoadenosine 5'-phosphate cyclic anhydride induced Ca2+ release in human T-cell lines.
European journal of biochemistry / FEBS 1997;245(2):411-7.
1997: Howarth N M; Purohit A; Reed M J; Potter B V
Estrone sulfonates as inhibitors of estrone sulfatase.
Steroids 1997;62(4):346-50.
1997: Guse A H; Berg I; da Silva C P; Potter B V; Mayr G W
Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytes.
The Journal of biological chemistry 1997;272(13):8546-50.
1997: Bailey V C; Sethi J K; Fortt S M; Galione A; Potter B V
7-Deaza cyclic adenosine 5'-diphosphate ribose: first example of a Ca(2+)-mobilizing partial agonist related to cyclic adenosine 5'-diphosphate ribose.
Chemistry & biology 1997;4(1):51-61.
1997: Guse A H; da Silva C P; Potter B V; Mayr G W
Ca(2+)-signalling in human T-lymphocytes. Potential roles for cyclic ADP-ribose and 2'-phospho-cyclic ADP-ribose.
Advances in experimental medicine and biology 1997;419():431-6.
1996: Jenkins D J; Riley A M; Potter B V
Chiral Cyclopentane-Based Mimics of D-myo-Inositol 1,4,5-Trisphosphate from D-Glucose.
The Journal of organic chemistry 1996;61(22):7719-26.

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