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John Potts

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TOP 3
Akira Maeda; Mathew Mahon; Makoto Okazaki; John T Potts; Hiroko Segawa; Abdul B Abou-Samra; David M Baron; Kenneth D Bloch; Thomas Dean; Harald Jüppner; Ashok Khatri; Thomas J Gardella
Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.
Makoto Okazaki; Sebastien Ferrandon; Jean-Pierre Vilardaga; Mary L Bouxsein; John T Potts; Thomas J Gardella
Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.
Thomas Dean; Jean-Pierre Vilardaga; John T Potts; Thomas J Gardella
Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.

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2013: Akira Maeda; Mathew Mahon; Makoto Okazaki; John T Potts; Hiroko Segawa; Abdul B Abou-Samra; David M Baron; Kenneth D Bloch; Thomas Dean; Harald Jüppner; Ashok Khatri; Thomas J Gardella
Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):5864-9.
2008: Makoto Okazaki; Sebastien Ferrandon; Jean-Pierre Vilardaga; Mary L Bouxsein; John T Potts; Thomas J Gardella
Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16525-30.
2008: Thomas Dean; Jean-Pierre Vilardaga; John T Potts; Thomas J Gardella
Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.
Molecular endocrinology (Baltimore, Md.) 2008;22(1):156-66.
2007: John T Potts; Thomas J Gardella
Progress, paradox, and potential: parathyroid hormone research over five decades.
Annals of the New York Academy of Sciences 2007;1117():196-208.
2006: Thomas Dean; Agnès Linglart; Matthew J Mahon; Murat Bastepe; Harald Jüppner; John T Potts; Thomas J Gardella
Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations.
Molecular endocrinology (Baltimore, Md.) 2006;20(4):931-43.
2005: John T Potts
Parathyroid hormone: past and present.
The Journal of endocrinology 2005;187(3):311-25.
2005: Naoto Shimizu; Thomas Dean; Janet C Tsang; Ashok Khatri; John T Potts; Thomas J Gardella
Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor.
The Journal of biological chemistry 2005;280(3):1797-807.
2002: Masaru Shimizu; Naoto Shimizu; Janet C Tsang; Brian D Petroni; Ashok Khatri; John T Potts; Thomas J Gardella
Residue 19 of the parathyroid hormone (PTH) modulates ligand interaction with the juxtamembrane region of the PTH-1 receptor.
Biochemistry 2002;41(44):13224-33.
2002: Harald Jüppner; John T Potts
Immunoassays for the detection of parathyroid hormone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17 Suppl 2():N81-6.
2001: Masaru Shimizu; Percy H Carter; Ashok Khatri; John T Potts; Thomas J Gardella
Enhanced activity in parathyroid hormone-(1-14) and -(1-11): novel peptides for probing ligand-receptor interactions.
Endocrinology 2001;142(7):3068-74.
2001: Percy H Carter; Brian D Petroni; Robert C Gensure; Ernestina Schipani; John T Potts; Thomas J Gardella
Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations.
Endocrinology 2001;142(4):1534-45.
2000: Masaru Shimizu; John T Potts; Thomas J Gardella
Minimization of parathyroid hormone. Novel amino-terminal parathyroid hormone fragments with enhanced potency in activating the type-1 parathyroid hormone receptor.
The Journal of biological chemistry 2000;275(29):21836-43.
1999: H Takasu; Thomas J Gardella; MD Luck; John T Potts; F Richard Bringhurst
Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands.
Biochemistry 1999;38(41):13453-60.
1997: John T Potts; Thomas J Gardella; Harald Jüppner; Henry M Kronenberg
Structure based design of parathyroid hormone analogs.
The Journal of endocrinology 1997;154 Suppl():S15-21.
1997: A Iida-Klein; Jun Guo; M Takemura; M T Drake; John T Potts; Abdul B Abou-Samra; F Richard Bringhurst; Gino V Segre
Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity.
The Journal of biological chemistry 1997;272(11):6882-9.
1997: John T Potts; Thomas J Gardella; Harald Jüppner; Henry M Kronenberg
The history of parathyroid hormone and its receptor: structure-based design of parathyroid hormone analogues.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1997;7 Suppl 3():S169-73.
1996: Clemens Bergwitz; Thomas J Gardella; M R Flannery; John T Potts; Henry M Kronenberg; Steven R Goldring; Harald Jüppner
Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction.
The Journal of biological chemistry 1996;271(43):26469-72.
1996: Thomas J Gardella; MD Luck; G S Jensen; Ernestina Schipani; John T Potts; Harald Jüppner
Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors.
Endocrinology 1996;137(9):3936-41.
1996: John T Potts
Hyperparathyroidism and other hypercalcemic disorders.
Advances in internal medicine 1996;41():165-212.
1995: C Lee; MD Luck; Harald Jüppner; John T Potts; Henry M Kronenberg; Thomas J Gardella
Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1269-78.
1995: A Iida-Klein; Jun Guo; L Y Xie; Harald Jüppner; John T Potts; Henry M Kronenberg; F Richard Bringhurst; Abdul B Abou-Samra; Gino V Segre
Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C.
The Journal of biological chemistry 1995;270(15):8458-65.
1995: Thomas J Gardella; MD Luck; A K Wilson; H T Keutmann; S R Nussbaum; John T Potts; Henry M Kronenberg
Parathyroid hormone (PTH)-PTH-related peptide hybrid peptides reveal functional interactions between the 1-14 and 15-34 domains of the ligand.
The Journal of biological chemistry 1995;270(12):6584-8.
1995: John T Potts
Non-traditional actions of parathyroid hormone: an overview.
Mineral and electrolyte metabolism 1995;21(1-3):9-12.
1994: C Lee; Thomas J Gardella; Abdul B Abou-Samra; S R Nussbaum; Gino V Segre; John T Potts; Henry M Kronenberg; Harald Jüppner
Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.
Endocrinology 1994;135(4):1488-95.
1994: Thomas J Gardella; Harald Jüppner; A K Wilson; H T Keutmann; Abdul B Abou-Samra; Gino V Segre; F Richard Bringhurst; John T Potts; S R Nussbaum; Henry M Kronenberg
Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor.
Endocrinology 1994;135(3):1186-94.
1994: X F Kong; Ernestina Schipani; Beate Lanske; H Joun; Marcel Karperien; Libert H K Defize; Harald Jüppner; John T Potts; Gino V Segre; Henry M Kronenberg
The rat, mouse, and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous.
Biochemical and biophysical research communications 1994;201(2):1058.
1994: X F Kong; Ernestina Schipani; Beate Lanske; H Joun; Marcel Karperien; Libert H K Defize; Harald Jüppner; John T Potts; Gino V Segre; Henry M Kronenberg
The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous.
Biochemical and biophysical research communications 1994;200(3):1290-9.
1994: Harald Jüppner; Ernestina Schipani; F Richard Bringhurst; I McClure; H T Keutmann; John T Potts; Henry M Kronenberg; Abdul B Abou-Samra; Gino V Segre; Thomas J Gardella
The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).
Endocrinology 1994;134(2):879-84.
1994: Abdul B Abou-Samra; Harald Jüppner; X F Kong; Ernestina Schipani; A Iida-Klein; H Karga; P Urena; T F Gardella; John T Potts; Henry M Kronenberg
Structure, function, and expression of the receptor for parathyroid hormone and parathyroid hormone-related peptide.
Advances in nephrology from the Necker Hospital 1994;23():247-64.
1993: Pablo Ureña; X F Kong; Abdul B Abou-Samra; Harald Jüppner; Henry M Kronenberg; John T Potts; Gino V Segre
Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues.
Endocrinology 1993;133(2):617-23.
1993: Ernestina Schipani; H Karga; A C Karaplis; John T Potts; Henry M Kronenberg; Gino V Segre; Abdul B Abou-Samra; Harald Jüppner
Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.
Endocrinology 1993;132(5):2157-65.
1993: F Richard Bringhurst; H Juppner; Jun Guo; P Urena; John T Potts; Henry M Kronenberg; Abdul B Abou-Samra; Gino V Segre
Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells.
Endocrinology 1993;132(5):2090-8.
1993: Thomas J Gardella; A K Wilson; H T Keutmann; R Oberstein; John T Potts; M Kronenberg; S R Nussbaum
Analysis of parathyroid hormone's principal receptor-binding region by site-directed mutagenesis and analog design.
Endocrinology 1993;132(5):2024-30.
1992: S Uneno; T Yamamuro; Harald Jüppner; Abdul B Abou-Samra; H T Keutmann; John T Potts; Gino V Segre
Solubilization of functional receptors for parathyroid hormone and parathyroid hormone-related peptide from clonal rat osteosarcoma cells, ROS17/2.8.
Calcified tissue international 1992;51(5):382-6.
1992: Abdul B Abou-Samra; Harald Jüppner; Thomas Force; Mason W Freeman; X F Kong; Ernestina Schipani; P Urena; J Richards; Joseph V Bonventre; John T Potts
Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2732-6.
1991: Harald Jüppner; Abdul B Abou-Samra; M Freeman; X F Kong; Ernestina Schipani; J Richards; L F Kolakowski; Janet Hock; John T Potts; Henry M Kronenberg
A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.
Science (New York, N.Y.) 1991;254(5034):1024-6.
1991: B H Mitlak; M Daly; John T Potts; D Schoenfeld; Robert M Neer
Asymptomatic primary hyperparathyroidism.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6 Suppl 2():S103-10; discussion S121-4.
1991: Thomas J Gardella; D Axelrod; D Rubin; H T Keutmann; John T Potts; Henry M Kronenberg; S R Nussbaum
Mutational analysis of the receptor-activating region of human parathyroid hormone.
The Journal of biological chemistry 1991;266(20):13141-6.
1990: Harald Jüppner; Abdul B Abou-Samra; S Uneno; Ernestina Schipani; H T Keutmann; John T Potts; Gino V Segre
Properties of amino-terminal parathyroid hormone-related peptides modified at positions 11-13.
Peptides 1990;11(6):1139-42.
1990: Thomas J Gardella; D Rubin; Abdul B Abou-Samra; H T Keutmann; John T Potts; Henry M Kronenberg; S R Nussbaum
Expression of human parathyroid hormone-(1-84) in Escherichia coli as a factor X-cleavable fusion protein.
The Journal of biological chemistry 1990;265(26):15854-9.
1990: Harald Jüppner; Abdul B Abou-Samra; S Uneno; H T Keutmann; John T Potts; Gino V Segre
Preparation and characterization of [N alpha-(4-azido-2-nitrophenyl)Ala1,Tyr36]-parathyroid hormone related peptide (1-36)amide: a high-affinity, partial agonist having high cross-linking efficiency with its receptor on ROS 17/2.8 cells.
Biochemistry 1990;29(30):6941-6.
1990: John T Potts
Clinical Review 9: Management of asymptomatic hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 1990;70(6):1489-93.
1989: Abdul B Abou-Samra; H Jueppner; John T Potts; Gino V Segre
Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells.
Endocrinology 1989;125(5):2594-9.
1989: Abdul B Abou-Samra; S Uneno; H Jueppner; H Keutmann; John T Potts; Gino V Segre; S R Nussbaum
Non-homologous sequences of parathyroid hormone and the parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells.
Endocrinology 1989;125(4):2215-7.
1989: F Richard Bringhurst; A M Stern; M Yotts; N Mizrahi; Gino V Segre; John T Potts
Peripheral metabolism of [35S]parathyroid hormone in vivo: influence of alterations in calcium availability and parathyroid status.
The Journal of endocrinology 1989;122(1):237-45.
1989: C Shigeno; Y Hiraki; H T Keutmann; A M Stern; John T Potts; Gino V Segre
Preparation of a photoreactive analog of parathyroid hormone [Nle8, Lys(N-epsilon-4-azido-2-nitrophenyl)13,Nle18,Tyr34]bovine parathyroid hormone-(1-34)NH2, a selective, high-affinity ligand for characterization of parathyroid hormone receptors.
Analytical biochemistry 1989;179(2):268-73.
1989: Abdul B Abou-Samra; H Jueppner; D Westerberg; John T Potts; Gino V Segre
Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells.
Endocrinology 1989;124(3):1107-13.
1989: Kristine Wiren; Lionel B Ivashkiv; P Ma; Mason W Freeman; John T Potts; Henry M Kronenberg
Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties.
Molecular endocrinology (Baltimore, Md.) 1989;3(2):240-50.
1988: Kristine Wiren; John T Potts; Henry M Kronenberg
Importance of the propeptide sequence of human preproparathyroid hormone for signal sequence function.
The Journal of biological chemistry 1988;263(36):19771-7.
1988: S Khosla; Marie B Demay; M Pines; S Hurwitz; John T Potts; Henry M Kronenberg
Nucleotide sequence of cloned cDNAs encoding chicken preproparathyroid hormone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1988;3(6):689-98.
1988: Harald Jüppner; Abdul B Abou-Samra; S Uneno; W X Gu; John T Potts; Gino V Segre
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.
The Journal of biological chemistry 1988;263(18):8557-60.
1988: I Yamamoto; F R Bringhurst; John T Potts; Gino V Segre
Properties of parathyroid hormone receptors on circulating bovine lymphocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1988;3(3):289-95.
1988: I Yamamoto; C Shigeno; John T Potts; Gino V Segre
Characterization and agonist-induced down-regulation of parathyroid hormone receptors in clonal rat osteosarcoma cells.
Endocrinology 1988;122(4):1208-17.
1988: C Shigeno; Y Hiraki; D P Westerberg; John T Potts; Gino V Segre
Parathyroid hormone receptors are plasma membrane glycoproteins with asparagine-linked oligosaccharides.
The Journal of biological chemistry 1988;263(8):3872-8.
1988: C Shigeno; Y Hiraki; D P Westerberg; John T Potts; Gino V Segre
Photoaffinity labeling of parathyroid hormone receptors in clonal rat osteosarcoma cells.
The Journal of biological chemistry 1988;263(8):3864-71.
1987: Mason W Freeman; Kristine Wiren; A Rapoport; M Lazar; John T Potts; Henry M Kronenberg
Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence.
Molecular endocrinology (Baltimore, Md.) 1987;1(9):628-38.
1987: S R Nussbaum; R J Zahradnik; J R Lavigne; G L Brennan; K Nozawa-Ung; L Y Kim; H T Keutmann; C A Wang; John T Potts; Gino V Segre
Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.
Clinical chemistry 1987;33(8):1364-7.
1987: W Born; M Freeman; W Bornstein; A Rapoport; R D Klein; G N Hendy; H Gobind Khorana; A Rich; John T Potts; Henry M Kronenberg
Signal sequence of human preproparathyroid hormone is inactive in yeast.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1987;2(4):353-60.
1987: W Born; M Freeman; G N Hendy; A Rapoport; A Rich; John T Potts; Henry M Kronenberg
Human preproparathyroid hormone synthesized in Escherichia coli is transported to the surface of the bacterial inner membrane but not processed to the mature hormone.
Molecular endocrinology (Baltimore, Md.) 1987;1(1):5-14.
1986: S H Doppelt; Robert M Neer; S R Nussbaum; P Federico; John T Potts; M Rosenblatt
Inhibition of the in vivo parathyroid hormone-mediated calcemic response in rats by a synthetic hormone antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7557-60.
1986: D M Slovik; D I Rosenthal; S H Doppelt; John T Potts; M A Daly; J A Campbell; Robert M Neer
Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1-34) and 1,25-dihydroxyvitamin D.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1986;1(4):377-81.
1985: H T Keutmann; A W Griscom; S R Nussbaum; B F Reiner; A N Goud; John T Potts; M Rosenblatt
Rat parathyroid hormone-(1-34) fragment: renal adenylate cyclase activity and receptor binding properties in vitro.
Endocrinology 1985;117(3):1230-4.
1984: D M Slovik; M A Daly; John T Potts; Robert M Neer
Renal 1,25-dihydroxyvitamin D, phosphaturic, and cyclic-AMP responses to intravenous synthetic human parathyroid hormone-(1-34) administration in normal subjects.
Clinical endocrinology 1984;20(4):369-75.
1983: thomas vasicek; B E McDevitt; Mason W Freeman; B J Fennick; G N Hendy; John T Potts; A Rich; Henry M Kronenberg
Nucleotide sequence of the human parathyroid hormone gene.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(8):2127-31.
1982: S H Doppelt; D M Slovik; Robert M Neer; J Nolan; R M Zusman; John T Potts
Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(2):640-4.
1981: D M Slovik; Robert M Neer; John T Potts
Short-term effects of synthetic human parathyroid hormone-(1--34) administration on bone mineral metabolism in osteoporotic patients.
The Journal of clinical investigation 1981;68(5):1261-71.
1981: D M Slovik; J S Adams; Robert M Neer; M F Holick; John T Potts
Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients.
The New England journal of medicine 1981;305(7):372-4.
1981: S H Doppelt; Robert M Neer; John T Potts
Human parathyroid hormone 1-34-mediated hypercalcemia in a rat model, and its inhibition by dichloromethane diphosphonate.
Calcified tissue international 1981;33(6):649-54.
1980: J A Majzoub; M Rosenblatt; B Fennick; R Maunus; Henry M Kronenberg; John T Potts; J F Habener
Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones.
The Journal of biological chemistry 1980;255(23):11478-83.
1980: D M Slovik; Robert M Neer; J L Ohman; F C Lowell; M B Clark; G V Segre; John T Potts
Parathyroid hormone and 25-hydroxyvitamin D levels in glucocorticoid-treated patients.
Clinical endocrinology 1980;12(3):243-8.
1972: G V Segre; Joel F Habener; D Powell; G W Tregear; John T Potts
Parathyroid Hormone in Human Plasma: IMMUNOCHEMICAL CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS.
The Journal of clinical investigation 1972;51(12):3163-72.