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Simon Poucher

Research Profile

Chemicals & Drugs

Anatomy

Muscle, Skeletal

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Muscle Contraction

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Publications

TOP 3
William N Washburn; Simon M Poucher
Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus.
Simon M Poucher; S Cheetham; J Francis; M Kirby; B Zinker; S P Vickers
Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes.
Serge Jabbour; James List; David W Boulton; Simon M Poucher; Timothy P Reilly; Joanne Saye; Mark Tirmenstein; Jean M Whaley; Shamik Parikh
Targeting renal glucose reabsorption for the treatment of type 2 diabetes mellitus using the SGLT2 inhibitor dapagliflozin.

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All Publications

2013: William N Washburn; Simon M Poucher
Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus.
Expert opinion on investigational drugs 2013;22(4):463-86.
2012: Simon M Poucher; S Cheetham; J Francis; M Kirby; B Zinker; S P Vickers
Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes.
Diabetes, obesity & metabolism 2012;14(10):918-26.
2012: Serge Jabbour; James List; David W Boulton; Simon M Poucher; Timothy P Reilly; Joanne Saye; Mark Tirmenstein; Jean M Whaley; Shamik Parikh
Targeting renal glucose reabsorption for the treatment of type 2 diabetes mellitus using the SGLT2 inhibitor dapagliflozin.
Postgraduate medicine 2012;124(4):62-73.
2012: Jean M Whaley; Shamik Parikh; Simon M Poucher; Timothy P Reilly; Joanne Saye; Mark Tirmenstein; James List
Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus.
Diabetes, metabolic syndrome and obesity : targets and therapy 2012;5():135-48.
2011: Katy J Brocklehurst; Anders Broo; Hayley S Brown; Roger J Butlin; David S Clarke; Öjvind Davidsson; Kristin Goldberg; Sam D Groombridge; Elizabeth E Kelly; Andrew Leach; Darren McKerrecher; Charles O'Donnell; Simon M Poucher; Paul Schofield; James S Scott; Joanne L Teague; Leanne Westgate; Matt J M Wood
Discovery, optimisation and in vivo evaluation of novel GPR119 agonists.
Bioorganic & medicinal chemistry letters 2011;21(24):7310-6.
2011: Victor P Bilan; Huw B Jones; Rachel M Mayers; Simon M Poucher; Eman M Salah; Sheldon Bastacky; Bradley Zinker; Stevan P Tofovic
Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats.
The Journal of endocrinology 2011;210(3):293-308.
2011: Joanne L Teague; Amie Gyte; Joanne E Peel; Kimberley C Young; Susan J G Loxham; Rachel M Mayers; Simon M Poucher
Reversibility of hyperglycaemia and islet abnormalities in the high fat-fed female ZDF rat model of type 2 diabetes.
Journal of pharmacological and toxicological methods 2011;63(1):15-23.
2010: Li-Wen Lee; Po-Wah So; Anthony N Price; James R C Parkinson; David J Larkman; Jane Halliday; Simon M Poucher; John A T Pugh; Alan G Cox; Cameron W McLeod; Jimmy D Bell
Manganese enhancement in non-CNS organs.
NMR in biomedicine 2010;23(8):931-8.
2010: Eike Floettmann; Laraine Gregory; Joanne Teague; John Myatt; Clare Hammond; Simon M Poucher; Huw B Jones
Prolonged inhibition of glycogen phosphorylase in livers of Zucker Diabetic Fatty rats models human glycogen storage diseases.
Toxicologic pathology 2010;38(3):393-401.
2008: Georgia Frangioudakis; Amie C Gyte; Susan J G Loxham; Simon M Poucher
The intravenous glucose tolerance test in cannulated Wistar rats: a robust method for the in vivo assessment of glucose-stimulated insulin secretion.
Journal of pharmacological and toxicological methods 2008;57(2):106-13.
2007: Simon M Poucher; Susan Freeman; Susan J G Loxham; G Convey; J B Bartlett; Joanne De Schoolmeester; Joanne L Teague; M Walker; Andrew Turnbull; A D Charles; F Carey; S Berg
An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia.
British journal of pharmacology 2007;152(8):1239-47.
2007: J Andrew Lockton; Simon M Poucher
Single dose glucagon (0.5 mg IV bolus) administration in healthy human volunteers is a robust model for assessment of glycogenolysis: characterisation of the glucose excursion after glucagon challenge.
Journal of pharmacological and toxicological methods 2007;55(1):86-90.
2007: Susan J G Loxham; Joanne L Teague; Simon M Poucher; Joanne De Schoolmeester; Andrew Turnbull; Frank Carey
Glucagon challenge in the rat: a robust method for the in vivo assessment of Glycogen phosphorlyase inhibitor efficacy.
Journal of pharmacological and toxicological methods 2007;55(1):71-7.
2006: Susan Freeman; J B Bartlett; G Convey; I Hardern; Joanne L Teague; Susan J G Loxham; J M Allen; Simon M Poucher; A D Charles
Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme.
British journal of pharmacology 2006;149(6):775-85.
2006: Catherine Arden; Andrew R Green; Laura J Hampson; Susan Aiston; Linda Härndahl; Cynthia C Greenberg; Matthew J Brady; Susan Freeman; Simon M Poucher; Loranne Agius
Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats.
The FEBS journal 2006;273(9):1989-99.
2005: Paul A Roberts; Susan J G Loxham; Simon M Poucher; Dumitru Constantin-Teodosiu; Paul L Greenhaff
Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2005;288(2):E327-34.
2004: James A Timmons; Dumitru Constantin-Teodosiu; Simon M Poucher; Paul L Greenhaff
Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.
The Journal of physiology 2004;561(Pt 3):851-9.
2004: Andrew R Green; Susan Aiston; Cynthia C Greenberg; Susan Freeman; Simon M Poucher; Matthew J Brady; Loranne Agius
The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation.
The Journal of biological chemistry 2004;279(45):46474-82.
2004: Paul L Greenhaff; Síun P Campbell-O'Sullivan; Dumitru Constantin-Teodosiu; Simon M Poucher; Paul A Roberts; James A Timmons
Metabolic inertia in contracting skeletal muscle: a novel approach for pharmacological intervention in peripheral vascular disease.
British journal of clinical pharmacology 2004;57(3):237-43.
2004: Chu-Huang Chen; Simon M Poucher; Jonathan Lu; Philip D Henry
Fibroblast growth factor 2: from laboratory evidence to clinical application.
Current vascular pharmacology 2004;2(1):33-43.
2002: Paul A Roberts; Susan J G Loxham; Simon M Poucher; Dumitru Constantin-Teodosiu; Paul L Greenhaff
The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle.
The Journal of physiology 2002;545(Pt 1):297-304.
2002: Paul A Roberts; Susan J G Loxham; Simon M Poucher; Dumitru Constantin-Teodosiu; Paul L Greenhaff
The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle.
The Journal of physiology 2002;544(Pt 2):591-602.
2002: Paul A Roberts; Susan J G Loxham; Simon M Poucher; Dumitru Constantin-Teodosiu; Paul L Greenhaff
Bicarbonate-induced alkalosis augments cellular acetyl group availability and isometric force during the rest-to-work transition in canine skeletal muscle.
Experimental physiology 2002;87(4):489-98.
2002: Paul L Greenhaff; Síun P Campbell-O'Sullivan; Dumitru Constantin-Teodosiu; Simon M Poucher; Paul A Roberts; James A Timmons
An acetyl group deficit limits mitochondrial ATP production at the onset of exercise.
Biochemical Society transactions 2002;30(2):275-80.
1998: James A Timmons; Simon M Poucher; Dumitru Constantin-Teodosiu; Ian A Macdonald; Paul L Greenhaff
Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction.
The American journal of physiology 1998;274(5 Pt 2):R1384-9.
1997: James A Timmons; Simon M Poucher; Dumitru Constantin-Teodosiu; Ian A Macdonald; Paul L Greenhaff
Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle.
The American journal of physiology 1997;273(2 Pt 1):E233-8.
1996: James A Timmons; Simon M Poucher; Dumitru Constantin-Teodosiu; V Worrall; I A MacDonald; Paul L Greenhaff
Metabolic responses of canine gracilis muscle during contraction with partial ischemia.
The American journal of physiology 1996;270(3 Pt 1):E400-6.
1996: James A Timmons; Simon M Poucher; Dumitru Constantin-Teodosiu; V Worrall; I A Macdonald; Paul L Greenhaff
Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia.
The Journal of clinical investigation 1996;97(3):879-83.