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Thomas Poulos

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TOP 3
Irina F Sevrioukova; Thomas L Poulos
Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir.
Kristin Jansen Labby; Huiying Li; Pavel Martásek; Thomas L Poulos; Linda J Roman; Richard B Silverman
Methylated N(ω)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction.
He Huang; Huiying Li; Pavel Martásek; Thomas L Poulos; Linda Roman; Richard B Silverman
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.

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All Publications

2013: Irina F Sevrioukova; Thomas L Poulos
Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir.
Journal of medicinal chemistry 2013;56(9):3733-41.
2013: Kristin Jansen Labby; Huiying Li; Pavel Martásek; Thomas L Poulos; Linda J Roman; Richard B Silverman
Methylated N(ω)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction.
Biochemistry 2013;52(18):3062-73.
2013: He Huang; Huiying Li; Pavel Martásek; Thomas L Poulos; Linda Roman; Richard B Silverman
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
Journal of medicinal chemistry 2013;56(7):3024-32.
2013: Huiyung Li; Thomas L Poulos; Sufeng Zhou; Changzheng Li; Paul David Gershon
Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid.
Acta crystallographica. Section D, Biological crystallography 2013;69(Pt 4):617-24.
2013: Irina F Sevrioukova; Thomas L Poulos
Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems.
Dalton transactions (Cambridge, England : 2003) 2013;42(9):3116-26.
2013: Huiying Li; Pavel Martásek; Jan Mataka; Thomas L Poulos; Linda J Roman; Silvia L Delker; Haitao Ji; James M Kraus; Kristin Jansen Labby; Fengtian Xue; Richard B Silverman
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorganic & medicinal chemistry 2013;21(5):1333-43.
2013: Thomas L Poulos; Huiying Li
Structural basis for isoform-selective inhibition in nitric oxide synthase.
Accounts of chemical research 2013;46(2):390-8.
2013: Thomas L Poulos; Yarrow Madrona
Oxygen activation and redox partner binding in cytochromes P450.
Biotechnology and applied biochemistry 2013;60(1):128-33.
2012: Lyndal M R Jensen; Yergalem T Meharenna; Thomas L Poulos; Victor L Davidson; Britt Hedman; Carrie M Wilmot; Ritimukta Sarangi
Geometric and electronic structures of the His-Fe(IV)=O and His-Fe(IV)-Tyr hemes of MauG.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2012;17(8):1241-55.
2012: Victoria S Jasion; Huiying Li; Stephanie H Pineda; Tzanko Doukov; Thomas L Poulos
Crystal structure of the Leishmania major peroxidase-cytochrome c complex.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18390-4.
2012: Yarrow Madrona; Huiying Li; Sarvind Tripathi; Thomas L Poulos
Crystal structures of substrate-free and nitrosyl cytochrome P450cin: implications for O(2) activation.
Biochemistry 2012;51(33):6623-31.
2012: He Huang; Haitao Ji; Qing Jing; Kristin Jansen Labby; Huiying Li; Pavel Martásek; Thomas L Poulos; Linda Roman; Richard B Silverman
Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
Journal of the American Chemical Society 2012;134(28):11559-72.
2012: Irina F Sevrioukova; Thomas L Poulos
Interaction of human cytochrome P4503A4 with ritonavir analogs.
Archives of biochemistry and biophysics 2012;520(2):108-16.
2012: Kristin Jansen Labby; Huiying Li; Pavel Martásek; Jan Mataka; Thomas L Poulos; Linda Roman; Haitao Ji; James M Kraus; Fengtian Xue; Richard B Silverman
Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.
Bioorganic & medicinal chemistry 2012;20(7):2435-43.
2012: Victoria S Jasion; Thomas L Poulos
Leishmania major peroxidase is a cytochrome c peroxidase.
Biochemistry 2012;51(12):2453-60.
2011: Fengtian Xue; Guoyao Xia; Silvia L Delker; Haitao Ji; James M Kraus; Kristin Jansen Labby; Huiying Li; Pavel Martásek; Jan Mataka; Thomas L Poulos; Linda Roman; Richard B Silverman
Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.
Journal of medicinal chemistry 2011;54(18):6399-403.
2011: Tzanko Doukov; Huiying Li; Ajay Sharma; Jeffrey D Martell; S Michael Soltis; Richard B Silverman; Thomas L Poulos
Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors.
Journal of the American Chemical Society 2011;133(21):8326-34.
2011: Fengtian Xue; Jianguo Fang; Silvia L Delker; Huiying Li; Pavel Martásek; Linda Roman; Thomas L Poulos; Richard B Silverman
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.
Journal of medicinal chemistry 2011;54(7):2039-48.
2011: Irina F Sevrioukova; Thomas L Poulos
Structural biology of redox partner interactions in P450cam monooxygenase: a fresh look at an old system.
Archives of biochemistry and biophysics 2011;507(1):66-74.
2010: Silvia L Delker; Fengtian Xue; Huiying Li; Joumana Jamal; Richard B Silverman; Thomas L Poulos
Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry 2010;49(51):10803-10.
2010: Haitao Ji; Silvia L Delker; Huiying Li; Pavel Martásek; Linda Roman; Thomas L Poulos; Richard B Silverman
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.
Journal of medicinal chemistry 2010;53(21):7804-24.
2010: Fengtian Xue; Huiying Li; Jianguo Fang; Linda Roman; Pavel Martásek; Thomas L Poulos; Richard B Silverman
Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
Bioorganic & medicinal chemistry letters 2010;20(21):6258-61.
2010: Irina F Sevrioukova; Thomas L Poulos
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18422-7.
2010: Fengtian Xue; Huiying Li; Silvia L Delker; Jianguo Fang; Pavel Martásek; Linda Roman; Thomas L Poulos; Richard B Silverman
Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase.
Journal of the American Chemical Society 2010;132(40):14229-38.
2010: Fengtian Xue; Jinwen Huang; Haitao Ji; Jianguo Fang; Huiying Li; Pavel Martásek; Linda Roman; Thomas L Poulos; Richard B Silverman
Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.
Bioorganic & medicinal chemistry 2010;18(17):6526-37.
2010: Yergalem T Meharenna; Thomas L Poulos
Using molecular dynamics to probe the structural basis for enhanced stability in thermal stable cytochromes P450.
Biochemistry 2010;49(31):6680-6.
2010: Thomas L Poulos
Thirty years of heme peroxidase structural biology.
Archives of biochemistry and biophysics 2010;500(1):3-12.
2010: Irina F Sevrioukova; Thomas L Poulos
Arginines 65 and 310 in putidaredoxin reductase are critical for interaction with putidaredoxin.
Biochemistry 2010;49(25):5160-6.
2010: Munirathinam Sundaramoorthy; Michael H Gold; Thomas L Poulos
Ultrahigh (0.93A) resolution structure of manganese peroxidase from Phanerochaete chrysosporium: implications for the catalytic mechanism.
Journal of inorganic biochemistry 2010;104(6):683-90.
2010: Irina F Sevrioukova; Thomas L Poulos; Inna Y Churbanova
Crystal structure of the putidaredoxin reductase x putidaredoxin electron transfer complex.
The Journal of biological chemistry 2010;285(18):13616-20.
2010: Silvia L Delker; Haitao Ji; Huiying Li; Joumana Jamal; Jianguo Fang; Fengtian Xue; Richard B Silverman; Thomas L Poulos
Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
Journal of the American Chemical Society 2010;132(15):5437-42.
2010: Yergalem T Meharenna; Tzanko Doukov; Huiying Li; S Michael Soltis; Thomas L Poulos
Crystallographic and single-crystal spectral analysis of the peroxidase ferryl intermediate.
Biochemistry 2010;49(14):2984-6.
2010: Jeffrey D Martell; Huiying Li; Tzanko Doukov; Pavel Martásek; Linda Roman; Michael Soltis; Thomas L Poulos; Richard B Silverman
Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
Journal of the American Chemical Society 2010;132(2):798-806.
2010: Inna Y Churbanova; Thomas L Poulos; Irina F Sevrioukova
Production and characterization of a functional putidaredoxin reductase-putidaredoxin covalent complex.
Biochemistry 2010;49(1):58-67.
2009: Tzanko Doukov; Huiying Li; Michael Soltis; Thomas L Poulos
Single crystal structural and absorption spectral characterizations of nitric oxide synthase complexed with N(omega)-hydroxy-L-arginine and diatomic ligands.
Biochemistry 2009;48(43):10246-54.
2009: Alexandra Ioanoviciu; Yergalem T Meharenna; Thomas L Poulos; Paul R Ortiz de Montellano
DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy.
Biochemistry 2009;48(25):5839-48.
2009: Jotaro Igarashi; Huiying Li; Joumana Jamal; Haitao Ji; Jianguo Fang; Graham R Lawton; Richard B Silverman; Thomas L Poulos
Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
Journal of medicinal chemistry 2009;52(7):2060-6.
2009: Haitao Ji; Huiying Li; Pavel Martásek; Linda Roman; Thomas L Poulos; Richard B Silverman
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
Journal of medicinal chemistry 2009;52(3):779-97.
2009: Haitao Ji; Sidhartha Tan; Jotaro Igarashi; Huiying Li; Matthew Derrick; Pavel Martásek; Linda Roman; Jeannette Vásquez-Vivar; Thomas L Poulos; Richard B Silverman
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.
Annals of neurology 2009;65(2):209-17.
2008: Huiying Li; Aditi Das; Hiruy Sibhatu; Joumana Jamal; Stephen G Sligar; Thomas L Poulos
Exploring the electron transfer properties of neuronal nitric-oxide synthase by reversal of the FMN redox potential.
The Journal of biological chemistry 2008;283(50):34762-72.
2008: Rudi Fasan; Yergalem T Meharenna; Christopher D Snow; Thomas L Poulos; Frances H Arnold
Evolutionary history of a specialized p450 propane monooxygenase.
Journal of molecular biology 2008;383(5):1069-80.
2008: Yergalem T Meharenna; Patricia Oertel; B Bhaskar; Thomas L Poulos
Engineering ascorbate peroxidase activity into cytochrome c peroxidase.
Biochemistry 2008;47(39):10324-32.
2008: Yergalem T Meharenna; Kate E Slessor; Sonia M Cavaignac; Thomas L Poulos; James J De Voss
The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in p450cin.
The Journal of biological chemistry 2008;283(16):10804-12.
2008: Haitao Ji; Benjamin Z Stanton; Jotaro Igarashi; Huiying Li; Pavel Martásek; Linda Roman; Thomas L Poulos; Richard B Silverman
Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.
Journal of the American Chemical Society 2008;130(12):3900-14.
2008: Winny W Ho; Huiying Li; Clinton R Nishida; Paul R Ortiz de Montellano; Thomas L Poulos
Crystal structure and properties of CYP231A2 from the thermoacidophilic archaeon Picrophilus torridus.
Biochemistry 2008;47(7):2071-9.
2007: Winny W Ho; Huiying Li; Suntara Eakanunkul; Yong Tong; Angela Wilks; Maolin Guo; Thomas L Poulos
Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins.
The Journal of biological chemistry 2007;282(49):35796-802.
2007: Mohammed Ibrahim; Michael Kuchinskas; Hwan Youn; Robert L Kerby; Gary P Roberts; Thomas L Poulos; Thomas G Spiro
Mechanism of the CO-sensing heme protein CooA: new insights from the truncated heme domain and UVRR spectroscopy.
Journal of inorganic biochemistry 2007;101(11-12):1776-85.
2007: Novelle Kimmich; Aditi Das; Irina F Sevrioukova; Yergalem T Meharenna; Stephen G Sligar; Thomas L Poulos
Electron transfer between cytochrome P450cin and its FMN-containing redox partner, cindoxin.
The Journal of biological chemistry 2007;282(37):27006-11.
2007: Mary C Corbett; Matthew J Latimer; Thomas L Poulos; Irina F Sevrioukova; Keith O Hodgson; Britt Hedman
Photoreduction of the active site of the metalloprotein putidaredoxin by synchrotron radiation.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 9):951-60.
2007: Aron M Levin; Katsuyuki Murase; Pilgrim J Jackson; Mack L Flinspach; Thomas L Poulos; Gregory A Weiss
Double barrel shotgun scanning of the caveolin-1 scaffolding domain.
ACS chemical biology 2007;2(7):493-500.
2007: Thomas L Poulos
The Janus nature of heme.
Natural product reports 2007;24(3):504-10.
2007: Jiwon Seo; Jotato Igarashi; Huiying Li; Pavel Martasek; Linda Roman; Thomas L Poulos; Richard B Silverman
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.
Journal of medicinal chemistry 2007;50(9):2089-99.
2007: Mandula Borjigin; Huiying Li; Nicholas D Lanz; Robert L Kerby; Gary P Roberts; Thomas L Poulos
Structure-based hypothesis on the activation of the CO-sensing transcription factor CooA.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 3):282-7.
2007: Jonathan Friedman; Yergalem T Meharenna; Angela Wilks; Thomas L Poulos
Diatomic ligand discrimination by the heme oxygenases from Neisseria meningitidis and Pseudomonas aeruginosa.
The Journal of biological chemistry 2007;282(2):1066-71.
2007: Thomas L Poulos
Structural biology of p450-oxy complexes.
Drug metabolism reviews 2007;39(2-3):557-66.
2006: Thomas L Poulos
Soluble guanylate cyclase.
Current opinion in structural biology 2006;16(6):736-43.
2006: Vadim Yu Kuznetsov; Thomas L Poulos; Irina F Sevrioukova
Putidaredoxin-to-cytochrome P450cam electron transfer: differences between the two reductive steps required for catalysis.
Biochemistry 2006;45(39):11934-44.
2006: Huiying Li; Jotaro Igarashi; Joumana Jamal; Weiping Yang; Thomas L Poulos
Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(6):753-68.
2006: Michael Kuchinskas; Huiying Li; Mary Conrad; Gary Roberts; Thomas L Poulos
The role of the DNA-binding domains in CooA activation.
Biochemistry 2006;45(23):7148-53.
2006: Bessie N A Mbadugha; Jiwon Seo; Haitao Ji; Pavel Martásek; Linda Roman; Thomas M Shea; Huiying Li; Thomas L Poulos; Richard B Silverman
Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase.
Bioorganic & medicinal chemistry 2006;14(11):3681-90.
2006: Larkin Swartz; Michael Kuchinskas; Huiying Li; Thomas L Poulos; William N Lanzilotta
Redox-dependent structural changes in the Azotobacter vinelandii bacterioferritin: new insights into the ferroxidase and iron transport mechanism.
Biochemistry 2006;45(14):4421-8.
2005: Thomas L Poulos
Structural biology of heme monooxygenases.
Biochemical and biophysical research communications 2005;338(1):337-45.
2005: Huiying Li; Mack L Flinspach; Jotaro Igarashi; Joumana Jamal; Weiping Yang; José A Gómez-Vidal; Elizabeth A Litzinger; Hui Huang; Erik P Erdal; Richard B Silverman; Thomas L Poulos
Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases.
Biochemistry 2005;44(46):15222-9.
2005: Tiffany P Barrows; Thomas L Poulos
Role of electrostatics and salt bridges in stabilizing the compound I radical in ascorbate peroxidase.
Biochemistry 2005;44(43):14062-8.
2005: Shingo Nagano; Thomas L Poulos
Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism.
The Journal of biological chemistry 2005;280(36):31659-63.
2005: Shingo Nagano; Jill R Cupp-Vickery; Thomas L Poulos
Crystal structures of the ferrous dioxygen complex of wild-type cytochrome P450eryF and its mutants, A245S and A245T: investigation of the proton transfer system in P450eryF.
The Journal of biological chemistry 2005;280(23):22102-7.
2005: B Bhaskar; Thomas L Poulos
The 1.13-A structure of iron-free cytochrome c peroxidase.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(4):425-30.
2005: Munirathinam Sundaramoorthy; Heather L Youngs; Michael H Gold; Thomas L Poulos
High-resolution crystal structure of manganese peroxidase: substrate and inhibitor complexes.
Biochemistry 2005;44(17):6463-70.
2005: Vadim Yu Kuznetsov; Emek Blair; Patrick J Farmer; Thomas L Poulos; Amanda Pifferitti; Irina F Sevrioukova
The putidaredoxin reductase-putidaredoxin electron transfer complex: theoretical and experimental studies.
The Journal of biological chemistry 2005;280(16):16135-42.
2005: Thomas L Poulos
Intermediates in P450 catalysis.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2005;363(1829):793-806; discussion 1035-40.
2005: Latesh Lad; Aleksey Koshkin; Paul R Ortiz de Montellano; Thomas L Poulos
Crystal structures of the G139A, G139A-NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(2):138-46.
2005: Jinling Wang; Latesh Lad; Thomas L Poulos; Paul R. Ortiz de Montellano
Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant.
The Journal of biological chemistry 2005;280(4):2797-806.
2005: Huiying Li; Thomas L Poulos
Structure-function studies on nitric oxide synthases.
Journal of inorganic biochemistry 2005;99(1):293-305.
2005: Thomas L Poulos
Structural and functional diversity in heme monooxygenases.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(1):10-8.
2004: Latesh Lad; Paul R. Ortiz de Montellano; Thomas L Poulos
Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage.
Journal of inorganic biochemistry 2004;98(11):1686-95.
2004: Jinling Wang; Fernando Niemevz; Latesh Lad; Liusheng Huang; Diego E Alvarez; Graciela Buldain; Thomas L Poulos; Paul R Ortiz de Montellano
Human heme oxygenase oxidation of 5- and 15-phenylhemes.
The Journal of biological chemistry 2004;279(41):42593-604.
2004: Shingo Nagano; Takehiko Tosha; Koichiro Ishimori; Isao Morishima; Thomas L Poulos
Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding.
The Journal of biological chemistry 2004;279(41):42844-9.
2004: Yergalem T Meharenna; Huiying Li; David B Hawkes; Andrew G Pearson; James J De Voss; Thomas L Poulos
Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam.
Biochemistry 2004;43(29):9487-94.
2004: Tiffany P Barrows; B Bhaskar; Thomas L Poulos
Electrostatic control of the tryptophan radical in cytochrome c peroxidase.
Biochemistry 2004;43(27):8826-34.
2004: Jonathan Friedman; Latesh Lad; Huiying Li; Angela Wilks; Thomas L Poulos
Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa.
Biochemistry 2004;43(18):5239-45.
2004: Mack L Flinspach; Huiying Li; Joumana Jamal; Weiping Yang; Hui Huang; Richard B Silverman; Thomas L Poulos
Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.
Biochemistry 2004;43(18):5181-7.
2004: Maolin Guo; B Bhaskar; Huiying Li; Tiffany P Barrows; Thomas L Poulos
Crystal structure and characterization of a cytochrome c peroxidase-cytochrome c site-specific cross-link.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):5940-5.
2004: Latesh Lad; Jonathan Friedman; Huying Li; B Bhaskar; Paul R. Ortiz de Montellano; Thomas L Poulos
Crystal structure of human heme oxygenase-1 in a complex with biliverdin.
Biochemistry 2004;43(13):3793-801.
2004: Irina F Sevrioukova; Huiying Li; Thomas L Poulos
Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase.
Journal of molecular biology 2004;336(4):889-902.
2004: Huiying Li; Thomas L Poulos
Crystallization of cytochromes P450 and substrate-enzyme interactions.
Current topics in medicinal chemistry 2004;4(16):1789-802.
2004: Mack L Flinspach; Huiying Li; Joumana Jamal; Weiping Yang; Hui Huang; Jung-Mi Hah; José A Gómez-Vidal; Elizabeth A Litzinger; Richard B Silverman; Thomas L Poulos
Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nature structural & molecular biology 2004;11(1):54-9.
2003: Haitao Ji; Huiying Li; Mack L Flinspach; Thomas L Poulos; Richard B Silverman
Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.
Journal of medicinal chemistry 2003;46(26):5700-11.
2003: Thomas L Poulos
The past and present of P450cam structural biology.
Biochemical and biophysical research communications 2003;312(1):35-9.
2003: Lynn E Bretscher; Huiying Li; Thomas L Poulos; Owen W Griffith
Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines.
The Journal of biological chemistry 2003;278(47):46789-97.
2003: Thomas L Poulos
Cytochrome P450 flexibility.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13121-2.
2003: Shingo Nagano; Huiying Li; Hideaki Shimizu; Clinton Nishida; Hiroshi Ogura; Paul R. Ortiz de Montellano; Thomas L Poulos
Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK.
The Journal of biological chemistry 2003;278(45):44886-93.
2003: Irina F Sevrioukova; Carlos Garcia; Huiying Li; B Bhaskar; Thomas L Poulos
Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida.
Journal of molecular biology 2003;333(2):377-92.
2003: Jonathan Friedman; Latesh Lad; Rahul Deshmukh; Huiying Li; Angela Wilks; Thomas L Poulos
Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation.
The Journal of biological chemistry 2003;278(36):34654-9.
2003: Latesh Lad; Jinling Wang; Huiying Li; Jonathan Friedman; B Bhaskar; Paul R. Ortiz de Montellano; Thomas L Poulos
Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications.
Journal of molecular biology 2003;330(3):527-38.
2003: Christopher A Bonagura; B Bhaskar; Hideaki Shimizu; Huiying Li; Munirathinam Sundaramoorthy; Duncan E McRee; David B Goodin; Thomas L Poulos
High-resolution crystal structures and spectroscopy of native and compound I cytochrome c peroxidase.
Biochemistry 2003;42(19):5600-8.
2003: B Bhaskar; Chad E Immoos; Hideaki Shimizu; Filip Sulc; Patrick J Farmer; Thomas L Poulos
A novel heme and peroxide-dependent tryptophan-tyrosine cross-link in a mutant of cytochrome c peroxidase.
Journal of molecular biology 2003;328(1):157-66.
2003: Latesh Lad; David J Schuller; Hideaki Shimizu; Jonathan Friedman; Huiying Li; Paul R. Ortiz de Montellano; Thomas L Poulos
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1.
The Journal of biological chemistry 2003;278(10):7834-43.
2003: Jason K Yano; Francesca Blasco; Huiying Li; Rolf D Schmid; Anke Henne; Thomas L Poulos
Preliminary characterization and crystal structure of a thermostable cytochrome P450 from Thermus thermophilus.
The Journal of biological chemistry 2003;278(1):608-16.
2002: Huiying Li; Hideaki Shimizu; Mack L Flinspach; Joumana Jamal; Weiping Yang; Ming Xian; Tingwei Cai; Edward Zhong Wen; Qiang Jia; Peng George Wang; Thomas L Poulos
The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis.
Biochemistry 2002;41(47):13868-75.
2002: Chad E Immoos; B Bhaskar; Michael S Cohen; Tiffany P Barrows; Patrick J Farmer; Thomas L Poulos
Mesopone cytochrome c peroxidase: functional model of heme oxygenated oxidases.
Journal of inorganic biochemistry 2002;91(4):635-43.
2002: Irina F Sevrioukova; Thomas L Poulos
Putidaredoxin reductase, a new function for an old protein.
The Journal of biological chemistry 2002;277(28):25831-9.
2002: B Bhaskar; Christopher A Bonagura; Huiying Li; Thomas L Poulos
Cation-induced stabilization of the engineered cation-binding loop in cytochrome c peroxidase (CcP).
Biochemistry 2002;41(8):2684-93.
2002: Huiying Li; Jason K Yano; Thomas L Poulos
Molecular replacement in P450 crystal structure determinations.
Methods in enzymology 2002;357():79-93.
2001: Peter Kotsonis; Lothar G Fröhlich; C.S. Raman; H Li; M Berg; R Gerwig; V Groehn; Y Kang; N Al-Masoudi; S Taghavi-Moghadam; D Mohr; U Münch; J Schnabel; Pavel Martásek; Bettie Sue Masters; Hartmut Strobel; Thomas L Poulos; Hans Matter; Wolfgang Pfleiderer; Harald Schmidt
Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin.
The Journal of biological chemistry 2001;276(52):49133-41.
2001: Larissa M Podust; J Stojan; Thomas L Poulos; Michael R Waterman
Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51.
Journal of inorganic biochemistry 2001;87(4):227-35.
2001: Hideaki Shimizu; David J Schuller; William N Lanzilotta; Munirathinam Sundaramoorthy; David M Arciero; Alan B Hooper; Thomas L Poulos
Crystal structure of Nitrosomonas europaea cytochrome c peroxidase and the structural basis for ligand switching in bacterial di-heme peroxidases.
Biochemistry 2001;40(45):13483-90.
2001: C.S. Raman; Huiying Li; Pavel Martásek; G Southan; Bettie Sue Masters; Thomas L Poulos
Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.
Biochemistry 2001;40(45):13448-55.
2001: David J Schuller; W Zhu; Igor Stojiljkovic; Angela Wilks; Thomas L Poulos
Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1.
Biochemistry 2001;40(38):11552-8.
2001: Irina F Sevrioukova; James T Hazzard; Gordon Tollin; Thomas L Poulos
Laser flash induced electron transfer in P450cam monooxygenase: putidaredoxin reductase-putidaredoxin interaction.
Biochemistry 2001;40(35):10592-600.
2001: C.S. Raman; Huiying Li; Pavel Martásek; suresh babu; Owen W Griffith; Bettie Sue Masters; Thomas L Poulos
Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.
The Journal of biological chemistry 2001;276(28):26486-91.
2001: Huiying Li; C.S. Raman; Pavel Martásek; Bettie Sue Masters; Thomas L Poulos
Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.
Biochemistry 2001;40(18):5399-406.
2001: Luke Lightning; H Huang ; P Moenne-Loccoz; Thomas M Loehr; David J Schuller; Thomas L Poulos; Paul R Ortiz de Montellano
Disruption of an active site hydrogen bond converts human heme oxygenase-1 into a peroxidase.
The Journal of biological chemistry 2001;276(14):10612-9.
2001: Larissa M Podust; Thomas L Poulos; Michael R Waterman
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3068-73.
2001: Gary P Roberts; Marc V Thorsteinsson; Robert L Kerby; William N Lanzilotta; Thomas L Poulos
CooA: a heme-containing regulatory protein that serves as a specific sensor of both carbon monoxide and redox state.
Progress in nucleic acid research and molecular biology 2001;67():35-63.
2000: Yong Liu; L Koenigs Lightning; H Huang; Pierre Moanne-Loccoz; David J Schuller; Thomas L Poulos; Thomas M Loehr; Paul R. Ortiz de Montellano
Replacement of the distal glycine 139 transforms human heme oxygenase-1 into a peroxidase.
The Journal of biological chemistry 2000;275(44):34501-7.
2000: Jason K Yano; L S Koo; David J Schuller; Huiying Li; Paul R. Ortiz de Montellano; Thomas L Poulos
Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus.
The Journal of biological chemistry 2000;275(40):31086-92.
2000: William N Lanzilotta; David J Schuller; Marc V Thorsteinsson; Robert L Kerby; Gary P Roberts; Thomas L Poulos
Structure of the CO sensing transcription activator CooA.
Nature structural biology 2000;7(10):876-80.
2000: Huiying Li; C.S. Raman; Pavel Martásek; V Král; Bettie Sue Masters; Thomas L Poulos
Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.
Journal of inorganic biochemistry 2000;81(3):133-9.
2000: EH Bursey; Thomas L Poulos
Two substrate binding sites in ascorbate peroxidase: the role of arginine 172.
Biochemistry 2000;39(25):7374-9.
1999: Christopher A Bonagura; B Bhaskar; Munirathinam Sundaramoorthy; Thomas L Poulos
Conversion of an engineered potassium-binding site into a calcium-selective site in cytochrome c peroxidase.
The Journal of biological chemistry 1999;274(53):37827-33.
1999: Irina F Sevrioukova; James T Hazzard; Gordon Tollin; Thomas L Poulos
The FMN to heme electron transfer in cytochrome P450BM-3. Effect of chemical modification of cysteines engineered at the FMN-heme domain interaction site.
The Journal of biological chemistry 1999;274(51):36097-106.
1999: Huiying Li; Thomas L Poulos
Fatty acid metabolism, conformational change, and electron transfer in cytochrome P-450(BM-3).
Biochimica et biophysica acta 1999;1441(2-3):141-9.
1999: David J Schuller; Angela Wilks; Paul R. Ortiz de Montellano; Thomas L Poulos
Crystal structure of human heme oxygenase-1.
Nature structural biology 1999;6(9):860-7.
1999: Thomas L Poulos
Helping copper find a home.
Nature structural biology 1999;6(8):709-11.
1999: Huiying Li; C.S. Raman; Charles B Glaser; Eric Blasko; T A Young; John Parkinson; Marc Whitlow; Thomas L Poulos
Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase.
The Journal of biological chemistry 1999;274(30):21276-84.
1999: Christopher A Bonagura; Munirathinam Sundaramoorthy; B Bhaskar; Thomas L Poulos
The effects of an engineered cation site on the structure, activity, and EPR properties of cytochrome c peroxidase.
Biochemistry 1999;38(17):5538-45.
1999: Thomas L Poulos; Huiying Li; C.S. Raman
Heme-mediated oxygen activation in biology: cytochrome c oxidase and nitric oxide synthase.
Current opinion in chemical biology 1999;3(2):131-7.
1999: Irina F Sevrioukova; Huiying Li; H Zhang; Julian A Peterson; Thomas L Poulos
Structure of a cytochrome P450-redox partner electron-transfer complex.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1863-8.
1999: J Cheek; D Mandelman; Thomas L Poulos; John H Dawson
A study of the K(+)-site mutant of ascorbate peroxidase: mutations of protein residues on the proximal side of the heme cause changes in iron ligation on the distal side.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(1):64-72.
1998: C.S. Raman; Huiying Li; Pavel Martásek; V Král; Bettie Sue Masters; Thomas L Poulos
Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center.
Cell 1998;95(7):939-50.
1998: D Mandelman; Joumana Jamal; Thomas L Poulos
Identification of two electron-transfer sites in ascorbate peroxidase using chemical modification, enzyme kinetics, and crystallography.
Biochemistry 1998;37(50):17610-7.
1998: D Mandelman; F P Schwarz; H Li; Thomas L Poulos
The role of quaternary interactions on the stability and activity of ascorbate peroxidase.
Protein science : a publication of the Protein Society 1998;7(10):2089-98.
1998: Munirathinam Sundaramoorthy; J Terner; Thomas L Poulos
Stereochemistry of the chloroperoxidase active site: crystallographic and molecular-modeling studies.
Chemistry & biology 1998;5(9):461-73.
1998: David J Schuller; Angela Wilks; Paul R. Ortiz de Montellano; Thomas L Poulos
Crystallization of recombinant human heme oxygenase-1.
Protein science : a publication of the Protein Society 1998;7(8):1836-8.
1998: M Nissum; Francesca Neri; D Mandelman; Thomas L Poulos; Giulietta Smulevich
Spectroscopic characterization of recombinant pea cytosolic ascorbate peroxidase: similarities and differences with cytochrome c peroxidase.
Biochemistry 1998;37(22):8080-7.
1998: Thomas L Poulos; C.S. Raman; Huiying Li
NO news is good news.
Structure (London, England : 1993) 1998;6(3):255-8.
1997: Michael Gajhede; David J Schuller; Anette Henriksen; Andrew T Smith; Thomas L Poulos
Crystal structure of horseradish peroxidase C at 2.15 A resolution.
Nature structural biology 1997;4(12):1032-8.
1997: Munirathinam Sundaramoorthy; K Kishi; Michael H Gold; Thomas L Poulos
Crystal structures of substrate binding site mutants of manganese peroxidase.
The Journal of biological chemistry 1997;272(28):17574-80.
1997: James T Hazzard; S Govindaraj; Thomas L Poulos; Gordon Tollin
Electron transfer between the FMN and heme domains of cytochrome P450BM-3. Effects of substrate and CO.
The Journal of biological chemistry 1997;272(12):7922-6.
1997: S Govindaraj; Thomas L Poulos
The domain architecture of cytochrome P450BM-3.
The Journal of biological chemistry 1997;272(12):7915-21.
1997: H Li; Thomas L Poulos
The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid.
Nature structural biology 1997;4(2):140-6.
1997: Jill R Cupp-Vickery; Thomas L Poulos
Structure of cytochrome P450eryF: substrate, inhibitors, and model compounds bound in the active site.
Steroids 1997;62(1):112-6.
1996: S Govindaraj; Thomas L Poulos
Probing the structure of the linker connecting the reductase and heme domains of cytochrome P450BM-3 using site-directed mutagenesis.
Protein science : a publication of the Protein Society 1996;5(7):1389-93.
1996: Jill R Cupp-Vickery; O Han; C R Hutchinson; Thomas L Poulos
Substrate-assisted catalysis in cytochrome P450eryF.
Nature structural biology 1996;3(7):632-7.
1996: Christopher A Bonagura; Munirathinam Sundaramoorthy; H S Pappa; W R Patterson; Thomas L Poulos
An engineered cation site in cytochrome c peroxidase alters the reactivity of the redox active tryptophan.
Biochemistry 1996;35(19):6107-15.
1996: H Pappa; Huiying Li; Munirathinam Sundaramoorthy; D Arciero; A Hooper; Thomas L Poulos
Crystallization and preliminary crystallographic analysis of cytochrome c553 peroxidase from Nitrosomonas europaea.
Journal of structural biology 1996;116(3):429-31.
1996: H S Pappa; S Tajbaksh; Aleister J Saunders; Gary J Pielak; Thomas L Poulos
Probing the cytochrome c peroxidase-cytochrome c electron transfer reaction using site specific cross-linking.
Biochemistry 1996;35(15):4837-45.
1996: David J Schuller; N Ban; R B Huystee; Alexander McPherson; Thomas L Poulos
The crystal structure of peanut peroxidase.
Structure (London, England : 1993) 1996;4(3):311-21.
1996: Thomas L Poulos
Approaches to crystallizing P450s.
Methods in enzymology 1996;272():358-68.
1995: Munirathinam Sundaramoorthy; J Terner; Thomas L Poulos
The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid.
Structure (London, England : 1993) 1995;3(12):1367-77.
1995: Giulietta Smulevich; Francesca Neri; O Willemsen; K Choudhury; MP Marzocchi; Thomas L Poulos
Effect of the His175-->Glu mutation on the heme pocket architecture of cytochrome c peroxidase.
Biochemistry 1995;34(41):13485-90.
1995: S Govindaraj; Thomas L Poulos
Role of the linker region connecting the reductase and heme domains in cytochrome P450BM-3.
Biochemistry 1995;34(35):11221-6.
1995: Munirathinam Sundaramoorthy; J M Mauro; A M Sullivan; J Terner; Thomas L Poulos
Preliminary crystallographic analysis of chloroperoxidase from Caldariomyces fumago.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):842-4.
1995: H S Pappa; Thomas L Poulos
Site-specific cross-linking as a method for studying intramolecular electron transfer.
Biochemistry 1995;34(20):6573-80.
1995: Thomas L Poulos; W R Patterson; Munirathinam Sundaramoorthy
The crystal structure of ascorbate and manganese peroxidases: the role of non-haem metal in the catalytic mechanism.
Biochemical Society transactions 1995;23(2):228-32.
1995: W R Patterson; Thomas L Poulos; D B Goodin
Identification of a porphyrin pi cation radical in ascorbate peroxidase compound I.
Biochemistry 1995;34(13):4342-5.
1995: W R Patterson; Thomas L Poulos
Crystal structure of recombinant pea cytosolic ascorbate peroxidase.
Biochemistry 1995;34(13):4331-41.
1995: Jill R Cupp-Vickery; Thomas L Poulos
Structure of cytochrome P450eryF involved in erythromycin biosynthesis.
Nature structural biology 1995;2(2):144-53.
1995: H Li; Thomas L Poulos
Modeling protein-substrate interactions in the heme domain of cytochrome P450(BM-3).
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 1):21-32.
1994: Munirathinam Sundaramoorthy; K Kishi; Michael H Gold; Thomas L Poulos
The crystal structure of manganese peroxidase from Phanerochaete chrysosporium at 2.06-A resolution.
The Journal of biological chemistry 1994;269(52):32759-67.
1994: Jill R Cupp-Vickery; H Li; Thomas L Poulos
Preliminary crystallographic analysis of an enzyme involved in erythromycin biosynthesis: cytochrome P450eryF.
Proteins 1994;20(2):197-201.
1994: S Gonvindaraj; Huiying Li; Thomas L Poulos
Flavin supported fatty acid oxidation by the heme domain of Bacillus megaterium cytochrome P450BM-3.
Biochemical and biophysical research communications 1994;203(3):1745-9.
1994: S F DeLauder; J M Mauro; Thomas L Poulos; J C Williams; Frederick P Schwarz
Thermodynamics of hydrogen cyanide and hydrogen fluoride binding to cytochrome c peroxidase and its Asn-82-->Asp mutant.
The Biochemical journal 1994;302 ( Pt 2)():437-42.
1994: K Choudhury; Munirathinam Sundaramoorthy; A Hickman; T Yonetani; E Woehl; Michael F Dunn; Thomas L Poulos
Role of the proximal ligand in peroxidase catalysis. Crystallographic, kinetic, and spectral studies of cytochrome c peroxidase proximal ligand mutants.
The Journal of biological chemistry 1994;269(32):20239-49.
1994: W R Patterson; Thomas L Poulos
Characterization and crystallization of recombinant pea cytosolic ascorbate peroxidase.
The Journal of biological chemistry 1994;269(25):17020-4.
1994: Huiying Li; Thomas L Poulos
Structural variation in heme enzymes: a comparative analysis of peroxidase and P450 crystal structures.
Structure (London, England : 1993) 1994;2(6):461-4.
1994: Munirathinam Sundaramoorthy; K Kishi; Michael H Gold; Thomas L Poulos
Preliminary crystallographic analysis of manganese peroxidase from Phanerochaete chrysosporium.
Journal of molecular biology 1994;238(5):845-8.
1993: Thomas L Poulos
Peroxidases.
Current opinion in biotechnology 1993;4(4):484-9.
1993: R Raag; Hongmin Li; B C Jones; Thomas L Poulos
Inhibitor-induced conformational change in cytochrome P-450CAM.
Biochemistry 1993;32(17):4571-8.
1993: Thomas L Poulos; S L Edwards; H Wariishi; Michael H Gold
Crystallographic refinement of lignin peroxidase at 2 A.
The Journal of biological chemistry 1993;268(6):4429-40.
1993: S L Edwards; R Raag; H Wariishi; M H Gold; Thomas L Poulos
Crystal structure of lignin peroxidase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):750-4.
1992: K Choudhury; Munirathinam Sundaramoorthy; J M Mauro; Thomas L Poulos
Conversion of the proximal histidine ligand to glutamine restores activity to an inactive mutant of cytochrome c peroxidase.
The Journal of biological chemistry 1992;267(36):25656-9.
1992: Thomas L Poulos; R Raag
Cytochrome P450cam: crystallography, oxygen activation, and electron transfer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):674-9.
1992: B Veerapandian; Gary L Gilliland; R Raag; A L Svensson; Y Masui; Y Hirai; Thomas L Poulos
Functional implications of interleukin-1 beta based on the three-dimensional structure.
Proteins 1992;12(1):10-23.
1991: R Raag; Susan A Martinis; Stephen G Sligar; Thomas L Poulos
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala.
Biochemistry 1991;30(48):11420-9.
1991: K Darwish; H Y Li; Thomas L Poulos
Engineering proteins, subcloning and hyperexpressing oxidoreductase genes.
Protein engineering 1991;4(6):701-8.
1991: H Y Li; K Darwish; Thomas L Poulos
Characterization of recombinant Bacillus megaterium cytochrome P-450 BM-3 and its two functional domains.
The Journal of biological chemistry 1991;266(18):11909-14.
1991: R Raag; Thomas L Poulos
Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation.
Biochemistry 1991;30(10):2674-84.
1990: R Raag; B A Swanson; Thomas L Poulos; Paul R. Ortiz de Montellano
Formation, crystal structure, and rearrangement of a cytochrome P-450cam iron-phenyl complex.
Biochemistry 1990;29(35):8119-26.
1990: S L Edwards; Thomas L Poulos
Ligand binding and structural perturbations in cytochrome c peroxidase. A crystallographic study.
The Journal of biological chemistry 1990;265(5):2588-95.
1989: R Raag; Thomas L Poulos
Crystal structure of the carbon monoxide-substrate-cytochrome P-450CAM ternary complex.
Biochemistry 1989;28(19):7586-92.
1989: H Furuya; T Shimizu; K Hirano; M Hatano; Y Fujii-Kuriyama; R Raag; Thomas L Poulos
Site-directed mutageneses of rat liver cytochrome P-450d: catalytic activities toward benzphetamine and 7-ethoxycoumarin.
Biochemistry 1989;28(17):6848-57.
1989: R Raag; Thomas L Poulos
The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM.
Biochemistry 1989;28(2):917-22.