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Colin Pouton

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Ravi Devraj; Anette Mullertz; Christopher J H Porter; Dallas B Warren; Hywel D Williams; Colin W Pouton
In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.
Hywel D Williams; Susan A Charman; William N Charman; Colin W Pouton; Ravi M Shanker; Natalie Trevaskis; Christopher J H Porter
Strategies to address low drug solubility in discovery and development.
Aaron J DeBono; Colin W Pouton; Sabatino Ventura; Jin Han Xie; Ben Capuano; Peter J Scammells
Synthesis and biological evaluation of N-substituted noscapine analogues.

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All Publications

2013: Ravi Devraj; Anette Mullertz; Christopher J H Porter; Dallas B Warren; Hywel D Williams; Colin W Pouton
In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.
International journal of pharmaceutics 2013;441(1-2):323-33.
2013: Hywel D Williams; Susan A Charman; William N Charman; Colin W Pouton; Ravi M Shanker; Natalie Trevaskis; Christopher J H Porter
Strategies to address low drug solubility in discovery and development.
Pharmacological reviews 2013;65(1):315-499.
2012: Aaron J DeBono; Colin W Pouton; Sabatino Ventura; Jin Han Xie; Ben Capuano; Peter J Scammells
Synthesis and biological evaluation of N-substituted noscapine analogues.
ChemMedChem 2012;7(12):2122-33.
2012: Hywel D Williams; Colin W Pouton; Philip Sassene; Jan Vertommen; Mette U Anby; Jean-Claude Bakala-N'Goma; Hassan Benameur; Ross Blundell; Marilyn Calderone; Frédéric Carrière; Annabel Igonin; Vincent Jannin; Eduardo Jule; Karen Kleberg; Mario Maio; Delphine Marchaud; Anette Müllertz; Anette Partheil; Christopher J H Porter
Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.
Molecular pharmaceutics 2012;9(11):3286-300.
2012: Paul J White; Martin J Scanlon; Linda Sze Tu; Ben J Boyd; Stephen J Headey; Pascal Hickey; Colin W Pouton
Colloidal characteristics and formulation of pure protein particulate vaccines.
The Journal of pharmacy and pharmacology 2012;64(10):1386-93.
2012: Hywel D Williams; Philip Sassene; Jan Vertommen; Jean-Claude Bakala-N'Goma; Hassan Benameur; Ross Blundell; Marilyn Calderone; Frédéric Carrière; Annabel Igonin; Vincent Jannin; Eduardo Jule; Karen Kleberg; Mario Maio; Delphine Marchaud; Anette Müllertz; Anette Partheil; Christopher J H Porter; Colin W Pouton
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations.
Journal of pharmaceutical sciences 2012;101(9):3360-80.
2012: Joshua I Gosling; John M Haynes; Michael Kassiou; Colin W Pouton; Lyndon Warfe; Paul J White; Stephen P Baker; Peter J Scammells
Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N(6)-substituents as adenosine A(1) receptor agonists.
ChemMedChem 2012;7(7):1191-201.
2012: Christian M Nefzger; Colin T Su; Wendy R Zeng; Siew J Beh; Stewart A Fabb; Brigham J Hartley; John M Haynes; Colin W Pouton
Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio) 2012;30(7):1349-61.
2012: Nicholas E Hausler; John M Haynes; Fiona M McRobb; Colin W Pouton; Steven E Bottle; Shane M Devine; Lyndon Warfe; Paul J White; Peter J Scammells
Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.
Journal of medicinal chemistry 2012;55(7):3521-34.
2012: Bradley Watmuff; Colin W Pouton; John M Haynes
In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.
PloS one 2012;7(2):e31999.
2011: David A Elliott; Adam L Goulburn; T Hatzistavrou; Susan M Hawes; John M Haynes; Claire E Hirst; Robert Jenny; David M Kaye; Ouda Khammy; Katerina Koutsis; Ebba L Lagerqvist; Xueling Li; Sue Mei Lim; Christine L Mummery; Ella S M Ng; Passier Robert; Colin W Pouton; Owen W J Prall; Rhys J P Skelton; Christine Biben; Stefan Braam; Richard P Davis; Andrew G Elefanty; Dorien Ward-van Oostwaard; Qing C Yu; Edouard G Stanley
NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.
Nature methods 2011;8(12):1037-40.
2011: Dylan T King; Colin W Pouton; Dallas B Warren; David K Chalmers
Using molecular dynamics to study liquid phase behavior: simulations of the ternary sodium laurate/sodium oleate/water system.
Langmuir : the ACS journal of surfaces and colloids 2011;27(18):11381-93.
2011: Wendy R Zeng; Stewart R A Fabb; John M Haynes; Colin W Pouton
Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1a expression and neurogenic potential.
Neurochemistry international 2011;59(3):394-403.
2011: S K Khaira; C M Nefzger; Colin W Pouton; S J Beh; John M Haynes
Midbrain and forebrain patterning delivers immunocytochemically and functionally similar populations of neuropeptide Y containing GABAergic neurons.
Neurochemistry international 2011;59(3):413-20.
2011: Christian M Nefzger; John M Haynes; Colin W Pouton
Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio) 2011;29(6):928-39.
2011: Daniela Martino Roth; Gregory W Moseley; Colin W Pouton; David A Jans
Mechanism of microtubule-facilitated "fast track" nuclear import.
The Journal of biological chemistry 2011;286(16):14335-51.
2011: Adam L Goulburn; Darym Alden; Richard P Davis; Suzanne J Micallef; Elizabeth S Ng; Qing C Yu; Sue Mei Lim; Chew-Li Soh; David A Elliott; T Hatzistavrou; Justin Bourke; Bradley Watmuff; Richard J Lang; John M Haynes; Colin W Pouton; Antonietta Giudice; Alan O Trounson; Stewart A Anderson; Edouard G Stanley; Andrew G Elefanty
A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives.
Stem cells (Dayton, Ohio) 2011;29(3):462-73.
2011: Shannen Lau; Colin W Pouton; Ben J Boyd; Bim Graham; Paul J White
Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds.
Journal of nucleic acids 2011;2011():154609.
2010: Dallas B Warren; Hassan Benameur; Christopher J H Porter; Colin W Pouton
Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility.
Journal of drug targeting 2010;18(10):704-31.
2010: Vijay B Urmaliya; Colin W Pouton; Catherine Ledent; Jennifer L Short; Paul J White
Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart.
Journal of cardiovascular pharmacology 2010;56(4):379-88.
2010: Ming Je Hsieh; Paul J White; Colin W Pouton
Interaction of viruses with host cell molecular motors.
Current opinion in biotechnology 2010;21(5):633-9.
2010: V Ann Chailertvanitkul; Colin W Pouton
Adenovirus: a blueprint for non-viral gene delivery.
Current opinion in biotechnology 2010;21(5):627-32.
2010: Vijay B Urmaliya; Colin W Pouton; Shane M Devine; John M Haynes; Lyndon Warfe; Peter J Scammells; Paul J White
A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do not affect heart rate.
Journal of cardiovascular pharmacology 2010;56(3):282-92.
2010: Shane M Devine; Alison Gregg; Heidi Figler; Kate McIntosh; Vijay Urmaliya; Joel Linden; Colin W Pouton; Paul J White; Steven E Bottle; Peter J Scammells
Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.
Bioorganic & medicinal chemistry 2010;18(9):3078-87.
2010: Jin Han Xie; Frédéric Hollande; John M Haynes; Colin W Pouton; Sabatino Ventura
Troubleshooting immunohistochemical labelling of proliferating cell nuclear antigen (PCNA) in cryocut tissue sections of mouse prostate.
Journal of pharmacological and toxicological methods 2010;61(2):98-101.
2009: S K Khaira; Colin W Pouton; John M Haynes
P2X2, P2X4 and P2Y1 receptors elevate intracellular Ca2+ in mouse embryonic stem cell-derived GABAergic neurons.
British journal of pharmacology 2009;158(8):1922-31.
2009: Kazi Mohsin; Michelle A Long; Colin W Pouton
Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution.
Journal of pharmaceutical sciences 2009;98(10):3582-95.
2009: Daniela Martino Roth; Ian Harper; Colin W Pouton; David A Jans
Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus.
Journal of cellular biochemistry 2009;107(6):1160-7.
2009: Cheng-Yi Kuo; Shubhra Sinha; Jalal A Jazayeri; Colin W Pouton
A stably engineered, suicidal strain of listeria monocytogenes delivers protein and/or DNA to fully differentiated intestinal epithelial monolayers.
Molecular pharmaceutics 2009;6(4):1052-61.
2009: Vijay B Urmaliya; Jarrod E Church; Ian M Coupar; Roselyn B Rose'Meyer; Colin W Pouton; Paul J White
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.
Journal of cardiovascular pharmacology 2009;53(5):424-33.
2009: Dallas B Warren; David K Chalmers; Colin W Pouton
Structure and dynamics of glyceride lipid formulations, with propylene glycol and water.
Molecular pharmaceutics 2009;6(2):604-14.
2009: Paul J White; Frank Anastasopoulos; Colin W Pouton; Ben J Boyd
Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides.
Expert reviews in molecular medicine 2009;11():e10.
2008: P J White; F Anastasopoulos; Jarrod E Church; C-Y Kuo; B J Boyd; P L C Hickey; L Sze Tu; P Burns; A M Lew; W R Heath; G M Davey; Colin W Pouton
Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants.
Vaccine 2008;26(52):6824-31.
2008: Jalal A Jazayeri; Richard J Prankerd; Colin W Pouton
Preparation and in vitro evaluation of novel lipopeptide transfection agents for efficient gene delivery.
Bioconjugate chemistry 2008;19(4):940-50.
2008: Christopher J H Porter; Colin W Pouton; Jean F Cuine; Jean Cuiné
Enhancing intestinal drug solubilisation using lipid-based delivery systems.
Advanced drug delivery reviews 2008;60(6):673-91.
2008: Colin W Pouton; Christopher J H Porter
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.
Advanced drug delivery reviews 2008;60(6):625-37.
2008: Jean Cuiné; Claire L McEvoy; William N Charman; Colin W Pouton; Glenn A Edwards; Hassan Benameur; Christopher J H Porter
Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs.
Journal of pharmaceutical sciences 2008;97(2):995-1012.
2007: Alison Gregg; Steven E Bottle; Shane M Devine; Heidi Figler; Joel Linden; Paul White; Colin W Pouton; Vijay Urmaliya; Peter J Scammells
Dual acting antioxidant A1 adenosine receptor agonists.
Bioorganic & medicinal chemistry letters 2007;17(19):5437-41.
2007: Colin W Pouton; Kylie M Wagstaff; Daniela Martino Roth; Gregory W Moseley; David A Jans
Targeted delivery to the nucleus.
Advanced drug delivery reviews 2007;59(8):698-717.
2007: Colin W Pouton; John M Haynes
Embryonic stem cells as a source of models for drug discovery.
Nature reviews. Drug discovery 2007;6(8):605-16.
2007: Gregory W Moseley; Daniela Martino Roth; Michelle A DeJesus; Denisse Leyton; Richard P Filmer; Colin W Pouton; David A Jans
Dynein light chain association sequences can facilitate nuclear protein import.
Molecular biology of the cell 2007;18(8):3204-13.
2007: Daniela Martino Roth; Gregory W Moseley; Dominic Glover; Colin W Pouton; David A Jans
A microtubule-facilitated nuclear import pathway for cancer regulatory proteins.
Traffic (Copenhagen, Denmark) 2007;8(6):673-86.
2007: Warren S Raye; Nathalie Tochon-Danguy; Colin W Pouton; John M Haynes
Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function.
The European journal of neuroscience 2007;25(7):1961-70.
2007: Jean Cuiné; William N Charman; Colin W Pouton; Glenn A Edwards; Christopher J H Porter
Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs.
Pharmaceutical research 2007;24(4):748-57.
2007: Helen R Irving; Yean Y Tan; Nathalie Tochon-Danguy; Haihuang Liu; Navinisha Chetty; Paul V Desmond; Colin W Pouton; Ian M Coupar
Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon.
Life sciences 2007;80(13):1198-205.
2006: Colin W Pouton
Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;29(3-4):278-87.
2005: Colin W Pouton; John M Haynes
Pharmaceutical applications of embryonic stem cells.
Advanced drug delivery reviews 2005;57(13):1918-34.
2005: F Martin; Daniela Martino Roth; David A Jans; Colin W Pouton; Lynda J Partridge; Peter N Monk; Gregory W Moseley
Tetraspanins in viral infections: a fundamental role in viral biology?
Journal of virology 2005;79(17):10839-51.
2004: Richard J Lang; John M Haynes; J Kelly; J Johnson; J Greenhalgh; C O'brien; E M Mulholland; L Baker; M Munsie; Colin W Pouton
Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation.
The European journal of neuroscience 2004;20(12):3209-21.
2001: Colin W Pouton
Polymeric materials for advanced drug delivery.
Advanced drug delivery reviews 2001;53(1):1-3.