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Jacques Pouysségur

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Johanna Chiche; Jean-Ehrland Ricci; Jacques Pouysségur
Tumor hypoxia and metabolism - Towards novel anticancer approaches.
S Grosso; Sandra Lacas-Gervais; Pascal Barbry; T Bertero; Bruno Cardinaud; J Doyen; Pierre GOUNON; Nathalie M Mazure; A Noël; S K Parks; A Paye; Jacques Pouysségur; Bernard Mari
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.
Yukiko Otsubo; Gilles Pagès; Jacques Pouysségur; Eiji Sakamoto; Yasushi Satoh; Maiko Satomoto; Yoshiyuki Araki; Shogo Endo; Mitsuyoshi Kodama; Tomiei Kazama
Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system.

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All Publications

2013: Johanna Chiche; Jean-Ehrland Ricci; Jacques Pouysségur
Tumor hypoxia and metabolism - Towards novel anticancer approaches.
Annales d'endocrinologie 2013;74(2):111-4.
2013: S Grosso; Sandra Lacas-Gervais; Pascal Barbry; T Bertero; Bruno Cardinaud; J Doyen; Pierre GOUNON; Nathalie M Mazure; A Noël; S K Parks; A Paye; Jacques Pouysségur; Bernard Mari
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.
Cell death & disease 2013;4():e544.
2012: Yukiko Otsubo; Gilles Pagès; Jacques Pouysségur; Eiji Sakamoto; Yasushi Satoh; Maiko Satomoto; Yoshiyuki Araki; Shogo Endo; Mitsuyoshi Kodama; Tomiei Kazama
Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system.
Pain 2012;153(11):2241-52.
2012: Hamid Mammar; Nathalie Mazure; Karima Mokhtari; Valérie Nataf; Marc Polivka; Dominique Pontvert; Jacques Pouysségur; Stéphane Clemenceau; Regis Ferrand; Loïc Feuvret; Bernard George; Jean-Louis Habrand; Khaldoun Kerrou; Guillaume Lot; Jean-Noël Talbot
Positron emission tomography/computed tomography imaging of residual skull base chordoma before radiotherapy using fluoromisonidazole and fluorodeoxyglucose: potential consequences for dose painting.
International journal of radiation oncology, biology, physics 2012;84(3):681-7.
2012: J Pelletier; Jacques Pouysségur; E Pécou; Frédéric Dayan; J Durivault; K Ilc; Nathalie M Mazure
The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis.
Oncogene 2012;31(24):2989-3001.
2012: Julie Garcia; Juan Lucio Iovanna; Jacques Pouysségur; Maria José Sandi; Bernard Binétruy; Pierre Cordelier; Roselyne Tournaire
Tie1 deficiency induces endothelial-mesenchymal transition.
EMBO reports 2012;13(5):431-9.
2012: Nicholas Goplen; Magdalena M Gorska; Lei Guo; Hua Huang; Zunayet Karim; Gilles Pagés; Jacques Pouysségur; Yonghua Zhuang; Erwin Gelfand; Rafeul Alam
ERK1 is important for Th2 differentiation and development of experimental asthma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(5):1934-45.
2012: M Christiane Brahimi-Horn; Jérôme Doyen; Pierre GOUNON; Paul Hofman; Véronique Hofman; Marius Ilie; Bernard Mari; Jacques Pouysségur; Matthieu Rouleau; Varda Shoshan-Barmatz; Danya Ben-Hail; Nathalie M Mazure
Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance.
Cancer research 2012;72(8):2140-50.
2012: Johanna Chiche; Patrick J Cozzone; Laurent Daniel; Frédéric Frassineti; Andrew P Halestrap; Jacques Pouysségur; Christophe Vilmen; Yann Le Fur; Norbert W Lutz
In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.
International journal of cancer. Journal international du cancer 2012;130(7):1511-20.
2012: Jérome Doyen; Serge Marcié; Scott K Parks; Jacques Pouysségur; Johanna Chiche
Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis.
Frontiers in oncology 2012;2():199.
2012: Joffrey Pelletier; Jacques Pouysségur; Grégory Bellot; Pierre GOUNON; Sandra Lacas-Gervais; Nathalie M Mazure
Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival.
Frontiers in oncology 2012;2():18.
2012: Nathalie Saulnier; Denis Clay; Elodie Decembre; Vincent Feuillet; Soizic Guihard; Xavier Holy; Pierre Jurdic; Gilles Pagès; Françoise Porteu; Jacques Pouysségur; Murielle Gaudry
ERK1 regulates the hematopoietic stem cell niches.
PloS one 2012;7(1):e30788.
2011: Jason C Morris; Jacques Pouysségur; Claudiu T Supuran; Laurent F Bornaghi; Johanna Chiche; Caroline Grellier; Marie Lopez; Alfonso Maresca; Sally-Ann Poulsen
Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors.
Journal of medicinal chemistry 2011;54(19):6905-18.
2011: Renaud Le Floch; Ibtissam Marchiq; Clare M Murray; Tanesha Naïken; Danièle Roux; Marie-Pierre Simon; Karine Ilc; Tanesha Naiken; Johanna Chiche; Susan E Critchlow; Karine Ilk; Jacques Pouysségur
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16663-8.
2011: Marius I Ilie; Véronique Hofman; Cécile Ortholan; Reda El Ammadi; Christelle Bonnetaud; Katia Havet; Nicolas Venissac; Jérôme Mouroux; Nathalie M Mazure; Jacques Pouysségur; Paul Hofman
Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis.
International journal of cancer. Journal international du cancer 2011;128(7):1614-23.
2011: Floriane Pez; Frédéric Dayan; Jérome Durivault; Bastien Kaniewski; Géraldine Aimond; Gabrielle Le Provost; Blandine Deux; Philippe Clézardin; Pascal Sommer; Jacques Pouysségur; Caroline Reynaud
The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth.
Cancer research 2011;71(5):1647-57.
2011: M-P Puisségur; Nathalie M Mazure; T Bertero; L Pradelli; S Grosso; K Robbe-Sermesant; T Maurin; K Lebrigand; Bruno Cardinaud; Véronique Hofman; S Fourre; Virginie Magnone; Jean-Ehrland Ricci; Jacques Pouysségur; Pierre GOUNON; Paul Hofman; Pascal Barbry; Bernard Mari
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity.
Cell death and differentiation 2011;18(3):465-78.
2011: M Christiane Brahimi-Horn; Gregory Bellot; Jacques Pouysségur
Hypoxia and energetic tumour metabolism.
Current opinion in genetics & development 2011;21(1):67-72.
2011: Yasushi Satoh; Yasushi Kobayashi; Atsuya Takeuchi; Gilles Pagès; Jacques Pouysségur; Tomiei Kazama
Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(3):1149-55.
2010: Jacques Pouysségur
[Tumor hypoxic and nutritional stress. New anticancer treatment].
Annales de pathologie 2010;30(5 Suppl 1):18-21.
2010: Osamu Imamura; Gilles Pagès; Jacques Pouysségur; Shogo Endo; Kunio Takishima
ERK1 and ERK2 are required for radial glial maintenance and cortical lamination.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(10):1072-88.
2010: M Ilie; Nathalie M Mazure; Véronique Hofman; R E Ammadi; Cécile Ortholan; C Bonnetaud; K Havet; Nicolas Venissac; Baharia Mograbi; Jérôme Mouroux; Jacques Pouysségur; Paul Hofman
High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer.
British journal of cancer 2010;102(11):1627-35.
2010: Soizic Guihard; Denis Clay; Laurence Cocault; Nathalie Saulnier; Paule Opolon; Michèle Souyri; Gilles Pagès; Jacques Pouysségur; Françoise Porteu; Murielle Gaudry
The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis.
Blood 2010;115(18):3686-94.
2010: Nathalie M Mazure; Jacques Pouysségur
Hypoxia-induced autophagy: cell death or cell survival?
Current opinion in cell biology 2010;22(2):177-80.
2010: Johanna Chiche; M Christiane Brahimi-Horn; Jacques Pouysségur
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.
Journal of cellular and molecular medicine 2010;14(4):771-94.
2010: Annick Harel-Bellan; Serge Evrard; Jacques Pouysségur
[Metamorphoses].
Bulletin du cancer 2010;97(3):287.
2010: Sang Jun Lee; Paul T Pfluger; Ji Young Kim; Ruben Nogueiras; Angeles Duran; Gilles Pagès; Jacques Pouysségur; Matthias H Tschöp; María T Diaz-Meco; Jorge Moscat
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis.
EMBO reports 2010;11(3):226-32.
2010: Mylène Heinis; Marie-Thérèse Simon; Karine Ilc; Nathalie M Mazure; Jacques Pouysségur; Raphael Scharfmann; Bertrand Duvillié
Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha.
Diabetes 2010;59(3):662-9.
2010: Johanna Chiche; Matthieu Rouleau; Pierre GOUNON; M Christiane Brahimi-Horn; Jacques Pouysségur; Nathalie M Mazure
Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli.
Journal of cellular physiology 2010;222(3):648-57.
2010: Diane S Lidke; Fang Huang; Janine Post; Bernd Rieger; Julie Wilsbacher; James L Thomas; Jacques Pouysségur; Thomas M Jovin; Philippe Lenormand
ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation.
The Journal of biological chemistry 2010;285(5):3092-102.
2010: Khadija Essafi-Benkhadir; Jacques Pouysségur; Gilles Pagès
Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability.
Methods in molecular biology (Clifton, N.J.) 2010;661():451-69.
2010: Veronica Huber; Angelo De Milito; Salvador Harguindey; Stephan J Reshkin; Miriam L Wahl; Cyril Rauch; Antonio Chiesi; Jacques Pouysségur; Robert A Gatenby; Licia Rivoltini; Stefano Fais
Proton dynamics in cancer.
Journal of translational medicine 2010;8():57.
2010: Johanna Chiche; Karine Ilc; M Christiane Brahimi-Horn; Jacques Pouysségur
Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration.
Advances in enzyme regulation 2010;50(1):20-33.
2009: Maureen A McGargill; Irene L Ch'en; Carol D Katayama; Gilles Pagès; Jacques Pouysségur; Stephen M Hedrick
Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):4838-42.
2009: Nathalie M Mazure; Jacques Pouysségur
Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia.
Autophagy 2009;5(6):868-9.
2009: Frédéric Dayan; Marc Monticelli; Jacques Pouysségur; Elisabeth Pécou
Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway.
Journal of theoretical biology 2009;259(2):304-16.
2009: Céline Loinard; Amandine Ginouvès; José Vilar; Clément Cochain; Yasmine Zouggari; Alice Recalde; Micheline Duriez; Bernard I Lévy; Jacques Pouysségur; Edurne Berra; Jean-Sébastien Silvestre
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.
Circulation 2009;120(1):50-9.
2009: Grégory Bellot; Raquel Garcia-Medina; Pierre GOUNON; Johanna Chiche; Danièle Roux; Jacques Pouysségur; Nathalie M Mazure
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.
Molecular and cellular biology 2009;29(10):2570-81.
2009: M Christiane Brahimi-Horn; Jacques Pouysségur
HIF at a glance.
Journal of cell science 2009;122(Pt 8):1055-7.
2009: M C Brahimi-Horn; Jacques Pouysségur
Highlights of the European Association of Cancer Research (EACR 2008).
Bulletin du cancer 2009;96(4):485-99.
2009: Renaud Lefloch; Jacques Pouysségur; Philippe Lenormand
Total ERK1/2 activity regulates cell proliferation.
Cell cycle (Georgetown, Tex.) 2009;8(5):705-11.
2009: Christophe Frémin; Anne Bessard; Frédéric Ezan; Luc Gailhouste; Morgane Régeard; Jacques Le Seyec; David Gilot; Gilles Pagès; Jacques Pouysségur; Sophie Langouët; Georges Baffet
Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2.
Hepatology (Baltimore, Md.) 2009;49(3):930-9.
2009: Johanna Chiche; Karine Ilc; Julie Laferrière; Eric Trottier; Frédéric Dayan; Nathalie M Mazure; M Christiane Brahimi-Horn; Jacques Pouysségur
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.
Cancer research 2009;69(1):358-68.
2008: Frédéric Dayan; Nathalie M Mazure; M Christiane Brahimi-Horn; Jacques Pouysségur
A dialogue between the hypoxia-inducible factor and the tumor microenvironment.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society 2008;1(1):53-68.
2008: Giorgos Fitsialos; Isabelle Bourget; Séverine Augier; Amandine Ginouvès; Roger Rezzonico; Teresa Odorisio; Francesca Cianfarani; Thierry Virolle; Jacques Pouysségur; Guerrino Meneguzzi; Edurne Berra; Gilles Ponzio; Roser Buscà
HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration.
Journal of cell science 2008;121(Pt 18):2992-3001.
2008: Laurent Turchi; Edith Aberdam; N Mazure; Jacques Pouysségur; Marcel Deckert; S Kitajima; Daniel Aberdam; Thierry Virolle
Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway.
Cell death and differentiation 2008;15(9):1472-80.
2008: Jessica Shama; Raquel Garcia-Medina; Jacques Pouysségur; Emmanuel Vial
Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells.
Biochemical and biophysical research communications 2008;372(4):845-9.
2008: Natalie C Tronson; Christina Schrick; Andre Fischer; Farahnaz Sananbenesi; Gilles Pagès; Jacques Pouysségur; Jelena Radulovic
Regulatory mechanisms of fear extinction and depression-like behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(7):1570-83.
2008: Tomoharu Yasuda; Hideki Sanjo; Gilles Pagès; Yohei Kawano; Hajime Karasuyama; Jacques Pouysségur; Masato Ogata; Tomohiro Kurosaki
Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.
Immunity 2008;28(4):499-508.
2008: Amandine Ginouvès; Karine Ilc; Nuria Macías; Jacques Pouysségur; Edurne Berra
PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4745-50.
2008: Yong-Sam Jung; Hye-Young Kim; Juno Kim; Min Goo Lee; Jacques Pouysségur; Eunhee Kim
Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death.
The Journal of biological chemistry 2008;283(2):1018-25.
2008: Renaud Lefloch; Jacques Pouysségur; Philippe Lenormand
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels.
Molecular and cellular biology 2008;28(1):511-27.
2008: Toru Nakazawa; Masahiko Shimura; Morin Ryu; Kohji Nishida; Gilles Pagès; Jacques Pouysségur; Shogo Endo
ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury.
Journal of neuroscience research 2008;86(1):136-44.
2007: M Christiane Brahimi-Horn; Johanna Chiche; Jacques Pouysségur
Hypoxia and cancer.
Journal of molecular medicine (Berlin, Germany) 2007;85(12):1301-7.
2007: Mélanie A Berta; Nathalie M Mazure; Maurice Hattab; Jacques Pouysségur; M Christiane Brahimi-Horn
SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity.
Biochemical and biophysical research communications 2007;360(3):646-52.
2007: Jean-Claude Chambard; Renaud Lefloch; Jacques Pouysségur; Philippe Lenormand
ERK implication in cell cycle regulation.
Biochimica et biophysica acta 2007;1773(8):1299-310.
2007: M Christiane Brahimi-Horn; Jacques Pouysségur
Oxygen, a source of life and stress.
FEBS letters 2007;581(19):3582-91.
2007: Christophe Frémin; Frédéric Ezan; Pierre Boisselier; Anne Bessard; Gilles Pagès; Jacques Pouysségur; Georges Baffet
ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes.
Hepatology (Baltimore, Md.) 2007;45(4):1035-45.
2007: M Christiane Brahimi-Horn; Johanna Chiche; Jacques Pouysségur
Hypoxia signalling controls metabolic demand.
Current opinion in cell biology 2007;19(2):223-9.
2007: Cynthia Trastour; Emmanuel Benizri; Francette Ettore; Alain Ramaioli; Emmanuel Chamorey; Jacques Pouysségur; Edurne Berra
HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.
International journal of cancer. Journal international du cancer 2007;120(7):1451-8.
2007: Un-Hwan Ha; Jae Hyang Lim; Hirofumi Jono; Tomoaki Koga; Amit Srivastava; Richard Malley; Gilles Pagès; Jacques Pouysségur; Jian-Dong Li
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1736-47.
2007: M Christiane Brahimi-Horn; Jacques Pouysségur
Harnessing the hypoxia-inducible factor in cancer and ischemic disease.
Biochemical pharmacology 2007;73(3):450-7.
2007: Edurne Berra; Jacques Pouysségur
The silencing approach of the hypoxia-signaling pathway.
Methods in enzymology 2007;435():107-21.
2007: M Christiane Brahimi-Horn; Jacques Pouysségur
Hypoxia in cancer cell metabolism and pH regulation.
Essays in biochemistry 2007;43():165-78.
2007: Erik Sahai; Raquel Garcia-Medina; Jacques Pouysségur; Emmanuel Vial
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility.
The Journal of cell biology 2007;176(1):35-42.
2006: Rebecca Bilton; Eric Trottier; Jacques Pouysségur; M Christiane Brahimi-Horn
ARDent about acetylation and deacetylation in hypoxia signalling.
Trends in cell biology 2006;16(12):616-21.
2006: Jacques Pouysségur; Fatima Mechta-Grigoriou
Redox regulation of the hypoxia-inducible factor.
Biological chemistry 2006;387(10-11):1337-46.
2006: Christiane Brahimi-Horn; Jacques Pouysségur
The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.
Bulletin du cancer 2006;93(8):E73-80.
2006: Jacques Pouysségur; Frédéric Dayan; Nathalie M Mazure
Hypoxia signalling in cancer and approaches to enforce tumour regression.
Nature 2006;441(7092):437-43.
2006: Christine Bourcier; Arnaud Jacquel; Jochen Hess; Isabelle Peyrottes; Peter Angel; Paul Hofman; Patrick Auberger; Jacques Pouysségur; Gilles Pagès
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.
Cancer research 2006;66(5):2700-7.
2006: Edurne Berra; Amandine Ginouvès; Jacques Pouysségur
The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.
EMBO reports 2006;7(1):41-5.
2006: Roser Buscà; Edurne Berra; Jacques Pouysségur; Robert Ballotti
[Hypoxia inducible factor 1a is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells].
Médecine sciences : M/S 2006;22(1):10-3.
2005: April M Fischer; Carol D Katayama; Giles Pagès; Jacques Pouysségur; Stephen M Hedrick
The role of erk1 and erk2 in multiple stages of T cell development.
Immunity 2005;23(4):431-43.
2005: Rebecca Bilton; Nathalie M Mazure; Eric Trottier; Maurice Hattab; Marc-André C Déry; Darren E Richard; Jacques Pouysségur; M Christiane Brahimi-Horn
Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF.
The Journal of biological chemistry 2005;280(35):31132-40.
2005: Roser Buscà; Edurne Berra; Cedric Gaggioli; Mehdi Khaled; Karine Bille; Barbara Marchetti; Raphaël Thyss; Giorgos Fitsialos; Lionel Larribère; Corine Bertolotto; Thierry Virolle; Pascal Barbry; Jacques Pouysségur; Gilles Ponzio; Robert Ballotti
Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells.
The Journal of cell biology 2005;170(1):49-59.
2005: Jean-Louis Formento; Edurne Berra; B Ferrua; Nicolas Magné; G Simos; Christiane Brahimi-Horn; Jacques Pouysségur; G Milano
Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1alpha.
Clinical and diagnostic laboratory immunology 2005;12(5):660-4.
2005: Gilles Pagès; Jacques Pouysségur
Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors.
Cardiovascular research 2005;65(3):564-73.
2005: Frédéric Bost; Myriam Aouadi; Leslie Caron; Patrick C Even; Nathalie Belmonte; Matthieu Prot; Christian Dani; Paul Hofman; Gilles Pagès; Jacques Pouysségur; Yannick Le Marchand-Brustel; Bernard Binétruy
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis.
Diabetes 2005;54(2):402-11.
2005: Christiane Brahimi-Horn; Jacques Pouysségur
When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy.
Critical reviews in oncology/hematology 2005;53(2):115-23.
2005: Sandrine Marchetti; Clotilde Gimond; Jean-Claude Chambard; Thomas Touboul; Danièle Roux; Jacques Pouysségur; Gilles Pagès
Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation.
Molecular and cellular biology 2005;25(2):854-64.
2005: M Christiane Brahimi-Horn; Jacques Pouysségur
The hypoxia-inducible factor and tumor progression along the angiogenic pathway.
International review of cytology 2005;242():157-213.
2005: Christiane Brahimi-Horn; Nathalie M Mazure; Jacques Pouysségur
Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications.
Cellular signalling 2005;17(1):1-9.
2004: Emmanuel Viala; Jacques Pouysségur
Regulation of tumor cell motility by ERK mitogen-activated protein kinases.
Annals of the New York Academy of Sciences 2004;1030():208-18.
2004: Damien Gerald; Edurne Berra; Yves-Michel Frapart; Denise A Chan; Amato J Giaccia; Daniel Mansuy; Jacques Pouysségur; Moshe Yaniv; Fatima Mechta-Grigoriou
JunD reduces tumor angiogenesis by protecting cells from oxidative stress.
Cell 2004;118(6):781-94.
2004: Nathalie M Mazure; M Christiane Brahimi-Horn; Mélanie A Berta; Emmanuel Benizri; Rebecca Bilton; Frédéric Dayan; Amandine Ginouvès; Edurne Berra; Jacques Pouysségur
HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs.
Biochemical pharmacology 2004;68(6):971-80.
2004: Sandrine Marchetti; Clotilde Gimond; Danièle Roux; E Gothié; Jacques Pouysségur; Gilles Pagès
Inducible expression of a MAP kinase phosphatase-3-GFP chimera specifically blunts fibroblast growth and ras-dependent tumor formation in nude mice.
Journal of cellular physiology 2004;199(3):441-50.
2004: Daniel J Lips; Orlando F Bueno; Benjamin J Wilkins; Nicole H Purcell; Robert A Kaiser; John N Lorenz; Laure Voisin; Marc K Saba-El-Leil; Sylvain Meloche; Jacques Pouysségur; Gilles Pagès; Leon J De Windt; Pieter A Doevendans; Jeffery D Molkentin
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.
Circulation 2004;109(16):1938-41.
2004: Roselyne Tournaire; Marie-Pierre Simon; Ferdinand le Noble; Anne Eichmann; Patrick England; Jacques Pouysségur
A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor.
EMBO reports 2004;5(3):262-7.
2004: Gilles Pagès; Jacques Pouysségur
Study of MAPK signaling using knockout mice.
Methods in molecular biology (Clifton, N.J.) 2004;250():155-66.
2003: Edurne Berra; Emmanuel Benizri; Amandine Ginouvès; Véronique Volmat; Danièle Roux; Jacques Pouysségur
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
The EMBO journal 2003;22(16):4082-90.
2003: Jacques Pouysségur; Philippe Lenormand
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling.
European journal of biochemistry / FEBS 2003;270(16):3291-9.
2003: Christophe Deroanne; Valérie Vouret-Craviari; Bingcheng Wang; Jacques Pouysségur
EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway.
Journal of cell science 2003;116(Pt 7):1367-76.
2003: Mireille Rossignol; Jacques Pouysségur; Michael Klagsbrun
Characterization of the neuropilin-1 promoter; gene expression is mediated by the transcription factor Sp1.
Journal of cellular biochemistry 2003;88(4):744-57.
2003: Nathalie M Mazure; M Christiane Brahimi-Horn; Jacques Pouysségur
Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis.
Current pharmaceutical design 2003;9(7):531-41.
2002: Elisabeth L Pagé; Geneviève A Robitaille; Jacques Pouysségur; Darren E Richard
Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms.
The Journal of biological chemistry 2002;277(50):48403-9.
2002: Marie Knockaert; Philippe Lenormand; Nathanael S Gray; Peter Schultz; Jacques Pouysségur; Laurent Meijer
p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
Oncogene 2002;21(42):6413-24.
2002: Jacques Pouysségur; Véronique Volmat; Philippe Lenormand
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling.
Biochemical pharmacology 2002;64(5-6):755-63.
2002: Ammar Gasmi; Christine Bourcier; Zohra Aloui; Najet Srairi; Sandrine Marchetti; Clotilde Gimond; Stephen R Wedge; Laurent F A Hennequin; Jacques Pouysségur
Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endothelial growth factor receptor signalling.
The Journal of biological chemistry 2002;277(33):29992-8.
2002: Julie Milanini-Mongiat; Jacques Pouysségur; Gilles Pagès
Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription.
The Journal of biological chemistry 2002;277(23):20631-9.
2002: Cristina Mazzucchelli; Chiara Vantaggiato; Alessandro Ciamei; Stefania Fasano; Pavel Pakhotin; Wojciech Krezel; Hans Welzl; David P Wolfer; Gilles Pagès; Olga Valverde; Anne Marowsky; Annamaria Porrazzo; Paul C Orban; Rafael Maldonado; Markus U Ehrengruber; Vincenzo Cestari; Hans-Peter Lipp; Paul F Chapman; Jacques Pouysségur; Riccardo Brambilla
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory.
Neuron 2002;34(5):807-20.
2002: Sandrine Marchetti; Clotilde Gimond; Kristiina Iljin; Christine Bourcier; Kari Alitalo; Jacques Pouysségur; Gilles Pagès
Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo.
Journal of cell science 2002;115(Pt 10):2075-85.
2001: Christiane Brahimi-Horn; Edurne Berra; Jacques Pouysségur
Hypoxia: the tumor's gateway to progression along the angiogenic pathway.
Trends in cell biology 2001;11(11):S32-6.
2001: F Viñals; Jacques Pouysségur
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
Molecular and cellular biology 2001;21(21):7218-30.
2001: Véronique Volmat; M Camps; Steve Arkinstall; Jacques Pouysségur; Philippe Lenormand
The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases.
Journal of cell science 2001;114(Pt 19):3433-43.
2001: Véronique Volmat; Jacques Pouysségur
Spatiotemporal regulation of the p42/p44 MAPK pathway.
Biology of the cell / under the auspices of the European Cell Biology Organization 2001;93(1-2):71-9.
2001: Edurne Berra; Danièle Roux; Darren E Richard; Jacques Pouysségur
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm.
EMBO reports 2001;2(7):615-20.
2001: Ferruccio Bonino; J Milanini; Jacques Pouysségur; Gilles Pagès
RT-PCR method to quantify vascular endothelial growth factor expression.
BioTechniques 2001;30(6):1254-6, 1258-60.
2001: M P Simon; M Navarro; D Roux; Jacques Pouysségur
Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma protuberans (DP).
Oncogene 2001;20(23):2965-75.
2001: F Viñals; F R McKenzie; Jacques Pouysségur
Growth factor-stimulated protein synthesis is inhibited by sodium orthovanadate.
European journal of biochemistry / FEBS 2001;268(8):2308-14.
2001: D E Richard; Valérie Vouret-Craviari; Jacques Pouysségur
Angiogenesis and G-protein-coupled receptors: signals that bridge the gap.
Oncogene 2001;20(13):1556-62.
2001: Edurne Berra; Darren E Richard; E Gothié; Jacques Pouysségur
HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation.
FEBS letters 2001;491(1-2):85-90.
2001: Jacques Pouysségur; A Franchi; Gilles Pagès
pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.
Novartis Foundation symposium 2001;240():186-96; discussion 196-8.
2000: Jacques Pouysségur
Signal transduction. An arresting start for MAPK.
Science (New York, N.Y.) 2000;290(5496):1515-8.
2000: K C Malcolm; Jean-Claude Chambard; Dominique Grall; Jacques Pouysségur; Ellen Van Obberghen-Schilling
Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts.
Journal of cellular physiology 2000;185(2):235-43.
2000: Edurne Berra; J Milanini; Darren E Richard; Maude Le Gall; F Viñals; E Gothié; Danièle Roux; Gilles Pagès; Jacques Pouysségur
Signaling angiogenesis via p42/p44 MAP kinase and hypoxia.
Biochemical pharmacology 2000;60(8):1171-8.
2000: Gilles Pagès; Edurne Berra; J Milanini; A P Levy; Jacques Pouysségur
Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability.
The Journal of biological chemistry 2000;275(34):26484-91.
2000: Gilles Pagès; J Milanini; Darren E Richard; Edurne Berra; E Gothié; F Viñals; Jacques Pouysségur
Signaling angiogenesis via p42/p44 MAP kinase cascade.
Annals of the New York Academy of Sciences 2000;902():187-200.
2000: E Gothié; Darren E Richard; Edurne Berra; Gilles Pagès; Jacques Pouysségur
Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha.
The Journal of biological chemistry 2000;275(10):6922-7.
2000: Maude Le Gall; Jean-Claude Chambard; J P Breittmayer; Dominique Grall; Jacques Pouysségur; Ellen Van Obberghen-Schilling
The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.
Molecular biology of the cell 2000;11(3):1103-12.
2000: Edurne Berra; Gilles Pagès; Jacques Pouysségur
MAP kinases and hypoxia in the control of VEGF expression.
Cancer metastasis reviews 2000;19(1-2):139-45.
1999: Darren E Richard; Edurne Berra; Jacques Pouysségur
Angiogenesis: how a tumor adapts to hypoxia.
Biochemical and biophysical research communications 1999;266(3):718-22.
1999: JM Brondello; Jacques Pouysségur; F R McKenzie
Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.
Science (New York, N.Y.) 1999;286(5449):2514-7.
1999: Gilles Pagès; S Guérin; Dominique Grall; F Bonino; A Smith; F Anjuere; Patrick Auberger; Jacques Pouysségur
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice.
Science (New York, N.Y.) 1999;286(5443):1374-7.
1999: Darren E Richard; Edurne Berra; E Gothié; Danièle Roux; Jacques Pouysségur
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.
The Journal of biological chemistry 1999;274(46):32631-7.
1999: F Viñals; Jean-Claude Chambard; Jacques Pouysségur
p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation.
The Journal of biological chemistry 1999;274(38):26776-82.
1999: Valérie Vouret-Craviari; Dominique Grall; Gilles Flatau; Jacques Pouysségur; Patrice Boquet; Ellen Van Obberghen-Schilling
Effects of cytotoxic necrotizing factor 1 and lethal toxin on actin cytoskeleton and VE-cadherin localization in human endothelial cell monolayers.
Infection and immunity 1999;67(6):3002-8.
1999: A Brunet; D Roux; Philippe Lenormand; Stephen Dowd; Stephen M Keyse; Jacques Pouysségur
Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.
The EMBO journal 1999;18(3):664-74.
1998: Maude Le Gall; Dominique Grall; Jean-Claude Chambard; Jacques Pouysségur; Ellen Van Obberghen-Schilling
An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression.
Oncogene 1998;17(10):1271-7.
1998: Valérie Vouret-Craviari; Patrice Boquet; Jacques Pouysségur; Ellen Van Obberghen-Schilling
Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function.
Molecular biology of the cell 1998;9(9):2639-53.
1998: Philippe Lenormand; JM Brondello; A Brunet; Jacques Pouysségur
Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins.
The Journal of cell biology 1998;142(3):625-33.
1998: J Milanini; F Viñals; Jacques Pouysségur; Gilles Pagès
p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts.
The Journal of biological chemistry 1998;273(29):18165-72.
1997: JM Brondello; A Brunet; Jacques Pouysségur; F R McKenzie
The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade.
The Journal of biological chemistry 1997;272(2):1368-76.
1997: L Bianchini; G L'Allemain; Jacques Pouysségur
The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors.
The Journal of biological chemistry 1997;272(1):271-9.
1996: J N Lavoie; G L'Allemain; A Brunet; R Müller; Jacques Pouysségur
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.
The Journal of biological chemistry 1996;271(34):20608-16.
1996: Nathalie Rivard; G L'Allemain; J Bartek; Jacques Pouysségur
Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts.
The Journal of biological chemistry 1996;271(31):18337-41.
1996: J Noel; D Roux; Jacques Pouysségur
Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines.
Journal of cell science 1996;109 ( Pt 5)():929-39.
1996: Y Chen; Dominique Grall; A E Salcini; P G Pelicci; Jacques Pouysségur; Ellen Van Obberghen-Schilling
Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.
The EMBO journal 1996;15(5):1037-44.
1996: J N Lavoie; Nathalie Rivard; G L'Allemain; Jacques Pouysségur
A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry.
Progress in cell cycle research 1996;2():49-58.
1995: G Pagès; E Richard Stanley; Maude Le Gall; A Brunet; Jacques Pouysségur
The mouse p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1) gene. Genomic organization and structure of the 5'-flanking regulatory region.
The Journal of biological chemistry 1995;270(45):26986-92.
1995: L Bianchini; Andras Kapus; Gergely L Lukacs; S Wasan; S Wakabayashi; Jacques Pouysségur; F H Yu; John Orlowski; Sergio Grinstein
Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress.
The American journal of physiology 1995;269(4 Pt 1):C998-1007.
1995: Ellen Van Obberghen-Schilling; Valérie Vouret-Craviari; Y H Chen; Dominique Grall; J C Chambard; Jacques Pouysségur
Thrombin and its receptor in growth control.
Annals of the New York Academy of Sciences 1995;766():431-41.
1995: J M Brondello; F R McKenzie; H Sun; N K Tonks; Jacques Pouysségur
Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts.
Oncogene 1995;10(10):1895-904.
1995: N Rivard; F R McKenzie; J M Brondello; Jacques Pouysségur
The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors.
The Journal of biological chemistry 1995;270(18):11017-24.
1995: C Papin; Alain Eychène; A Brunet; G Pagès; Jacques Pouysségur; Georges Calothy; J V Barnier
B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.
Oncogene 1995;10(8):1647-51.
1995: Valérie Vouret-Craviari; Dominique Grall; J C Chambard; Ulla rasmussen; Jacques Pouysségur; Ellen Van Obberghen-Schilling
Post-translational and activation-dependent modifications of the G protein-coupled thrombin receptor.
The Journal of biological chemistry 1995;270(14):8367-72.
1995: Valérie Vouret-Craviari; Patrick Auberger; Jacques Pouysségur; Ellen Van Obberghen-Schilling
Distinct mechanisms regulate 5-HT2 and thrombin receptor desensitization.
The Journal of biological chemistry 1995;270(9):4813-21.
1995: L Counillon; Jacques Pouysségur
Structure-function studies and molecular regulation of the growth factor activatable sodium-hydrogen exchanger (NHE-1).
Cardiovascular research 1995;29(2):147-54.
1995: A Brunet; J M Brondello; G L'Allemain; Philippe Lenormand; F McKenzie; G Pagès; Jacques Pouysségur
[MAP kinase module: role in the control of cell proliferation].
Comptes rendus des séances de la Société de biologie et de ses filiales 1995;189(1):43-57.
1994: A Brunet; G Pagès; Jacques Pouysségur
Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts.
Oncogene 1994;9(11):3379-87.
1994: L Counillon; Jacques Pouysségur; R A Reithmeier
The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain.
Biochemistry 1994;33(34):10463-9.
1994: G Pagès; A Brunet; G L'Allemain; Jacques Pouysségur
Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).
The EMBO journal 1994;13(13):3003-10.
1994: A Brunet; G Pagès; Jacques Pouysségur
Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1).
FEBS letters 1994;346(2-3):299-303.
1994: Jacques Pouysségur
Molecular biology and hormonal regulation of vertebrate Na+/H+ exchanger isoforms.
Renal physiology and biochemistry 1994;17(3-4):190-3.
1994: Bernard Mari; V Imbert; Nathalie Belhacene; D F Far; Jean-François Peyron; Jacques Pouysségur; Ellen Van Obberghen-Schilling; Bernard Rossi; Patrick Auberger
Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
The Journal of biological chemistry 1994;269(11):8517-23.
1994: P Fafournoux; J Noël; Jacques Pouysségur
Evidence that Na+/H+ exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers.
The Journal of biological chemistry 1994;269(4):2589-96.
1993: G Pagès; Philippe Lenormand; G L'Allemain; J C Chambard; S Meloche; Jacques Pouysségur
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8319-23.
1993: Philippe Lenormand; C Sardet; G Pagès; G L'Allemain; A Brunet; Jacques Pouysségur
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts.
The Journal of cell biology 1993;122(5):1079-88.
1993: Ulla rasmussen; Christian Gachet; Y Schlesinger; Daniel Hanau; Philippe Ohlmann; Ellen Van Obberghen-Schilling; Jacques Pouysségur; J P Cazenave; A Pavirani
A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets.
The Journal of biological chemistry 1993;268(19):14322-8.
1993: Ellen Van Obberghen-Schilling; Ulla rasmussen; Valérie Vouret-Craviari; K U Lentes; A Pavirani; Jacques Pouysségur
Structure-activity analysis of synthetic alpha-thrombin-receptor-activating peptides.
The Biochemical journal 1993;292 ( Pt 3)():667-71.
1993: Jacques Pouysségur; G L'Allemain; Philippe Lenormand; G Pagès; A Pavirani; Ulla rasmussen; Ellen Van Obberghen-Schilling; Valérie Vouret-Craviari
Alpha-thrombin receptor and MAP kinases in the control of cell growth.
Nouvelle revue française d'hématologie 1993;35(3):263-4.
1993: L Counillon; A Franchi; Jacques Pouysségur
A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4508-12.
1993: L Counillon; Jacques Pouysségur
Nucleotide sequence of the Chinese hamster Na+/H+ exchanger NHE1.
Biochimica et biophysica acta 1993;1172(3):343-5.
1993: Philippe Lenormand; G Pagès; C Sardet; G L'Allemain; S Meloche; Jacques Pouysségur
MAP kinases: activation, subcellular localization and role in the control of cell proliferation.
Advances in second messenger and phosphoprotein research 1993;28():237-44.
1993: Valérie Vouret-Craviari; Ellen Van Obberghen-Schilling; J C Scimeca; E Van Obberghen; Jacques Pouysségur
Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist.
The Biochemical journal 1993;289 ( Pt 1)():209-14.
1992: C Kahan; K Seuwen; S Meloche; Jacques Pouysségur
Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.
The Journal of biological chemistry 1992;267(19):13369-75.
1992: C Kahan; D Julius; Jacques Pouysségur; K Seuwen
Effects of 5-HT1C-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype.
Experimental cell research 1992;200(2):523-7.
1992: S Meloche; K Seuwen; G Pagès; Jacques Pouysségur
Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.
Molecular endocrinology (Baltimore, Md.) 1992;6(5):845-54.
1992: S Wakabayashi; P Fafournoux; C Sardet; Jacques Pouysségur
The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2424-8.
1992: S Meloche; G Pagès; Jacques Pouysségur
Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.
Molecular biology of the cell 1992;3(1):63-71.
1992: K Seuwen; Jacques Pouysségur
G protein-controlled signal transduction pathways and the regulation of cell proliferation.
Advances in cancer research 1992;58():75-94.
1992: S Wakabayashi; C Sardet; P Fafournoux; L Counillon; S Meloche; G Pagés; Jacques Pouysségur
Structure function of the growth factor-activatable Na+/H+ exchanger (NHE1).
Reviews of physiology, biochemistry and pharmacology 1992;119():157-86.
1992: Jacques Pouysségur; K Seuwen
Transmembrane receptors and intracellular pathways that control cell proliferation.
Annual review of physiology 1992;54():195-210.
1992: Valérie Vouret-Craviari; Ellen Van Obberghen-Schilling; Ulla rasmussen; A Pavirani; J P Lecocq; Jacques Pouysségur
Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis.
Molecular biology of the cell 1992;3(1):95-102.
1991: C Sardet; P Fafournoux; Jacques Pouysségur
Alpha-thrombin, epidermal growth factor, and okadaic acid activate the Na+/H+ exchanger, NHE-1, by phosphorylating a set of common sites.
The Journal of biological chemistry 1991;266(29):19166-71.
1991: P Fafournoux; J Ghysdael; C Sardet; Jacques Pouysségur
Functional expression of the human growth factor activatable Na+/H+ antiporter (NHE-1) in baculovirus-infected cells.
Biochemistry 1991;30(39):9510-5.
1991: Ulla rasmussen; Valérie Vouret-Craviari; S Jallat; Y Schlesinger; G Pagès; A Pavirani; J P Lecocq; Jacques Pouysségur; Ellen Van Obberghen-Schilling
cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization.
FEBS letters 1991;288(1-2):123-8.
1991: Ellen Van Obberghen-Schilling; Valérie Vouret-Craviari; R J Haslam; J C Chambard; Jacques Pouysségur
Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype.
Molecular endocrinology (Baltimore, Md.) 1991;5(7):881-9.
1991: R T Miller; L Counillon; G Pages; R P Lifton; C Sardet; Jacques Pouysségur
Structure of the 5'-flanking regulatory region and gene for the human growth factor-activatable Na/H exchanger NHE-1.
The Journal of biological chemistry 1991;266(17):10813-9.
1990: J C Chambard; Ellen Van Obberghen-Schilling; R J Haslam; V Vouret; Jacques Pouysségur
Chinese hamster serotonin (5-HT) type 2 receptor cDNA sequence.
Nucleic acids research 1990;18(17):5282.
1990: S Paris; Jacques Pouysségur
Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.
The Journal of biological chemistry 1990;265(20):11567-75.
1990: K Seuwen; I Magnaldo; B K Kobilka; Marc G Caron; John W Regan; R J Lefkowitz; Jacques Pouysségur
Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene.
Cell regulation 1990;1(6):445-51.
1990: Ellen Van Obberghen-Schilling; J C Chambard; Philippe Lory; Joël Nargeot; Jacques Pouysségur
Functional expression of Ca2(+)-mobilizing alpha-thrombin receptors in mRNA-injected Xenopus oocytes.
FEBS letters 1990;262(2):330-4.
1990: K Seuwen; Jacques Pouysségur
Serotonin as a growth factor.
Biochemical pharmacology 1990;39(6):985-90.
1990: C Sardet; L Counillon; A Franchi; Jacques Pouysségur
Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD.
Science (New York, N.Y.) 1990;247(4943):723-6.
1990: T Hartmann; K Seuwen; M F Roussel; C J Sherr; Jacques Pouysségur
Functional expression of the human receptor for colony-stimulating factor 1 (CSF-1) in hamster fibroblasts: CSF-1 stimulates Na+/H+ exchange and DNA-synthesis in the absence of phosphoinositide breakdown.
Growth factors (Chur, Switzerland) 1990;2(4):289-300.
1989: C Sardet; A Franchi; Jacques Pouysségur
Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.
Cell 1989;56(2):271-80.
1988: F Pichon; K Seuwen; Jacques Pouysségur; A E Lagarde
Progressive relaxation of Go-arrest controls and altered responsiveness to insulin, EGF and thrombin in CCL39 lung fibroblasts over-expressing myc and ras oncogenes.
Oncogene 1988;3(4):373-81.
1988: K Seuwen; I Magnaldo; Jacques Pouysségur
Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein.
Nature 1988;335(6187):254-6.
1988: S Paris; Jean-Claude Chambard; Jacques Pouysségur
Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways.
The Journal of biological chemistry 1988;263(26):12893-900.
1988: S Paris; I Magnaldo; Jacques Pouysségur
Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts.
The Journal of biological chemistry 1988;263(23):11250-6.
1988: I Magnaldo; Jacques Pouysségur; S Paris
Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C.
The Biochemical journal 1988;253(3):711-9.
1988: Jacques Pouysségur; J C Chambard; G L'Allemain; I Magnaldo; K Seuwen
Transmembrane signalling pathways initiating cell growth in fibroblasts.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1988;320(1199):427-36.
1988: J C Chambard; Jacques Pouysségur
TGF-beta inhibits growth factor-induced DNA synthesis in hamster fibroblasts without affecting the early mitogenic events.
Journal of cellular physiology 1988;135(1):101-7.
1988: A E Lagarde; A J Franchi; S Paris; Jacques Pouysségur
Effect of mutations affecting Na+: H+ antiport activity on tumorigenic potential of hamster lung fibroblasts.
Journal of cellular biochemistry 1988;36(3):249-60.
1988: K Seuwen; A Lagarde; Jacques Pouysségur
Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.
The EMBO journal 1988;7(1):161-8.
1987: Jacques Pouysségur; A Franchi; G L'Allemain; I Magnaldo; S Paris; C Sardet
Genetic approach to structure, function, and regulation of the Na+/H+ antiporter.
Kidney international. Supplement 1987;23():S144-55.
1987: Michel Moenner; I Magnaldo; G L'Allemain; Denis Barritault; Jacques Pouysségur
Early and late mitogenic events induced by FGF on bovine epithelial lens cells are not triggered by hydrolysis of polyphosphoinositides.
Biochemical and biophysical research communications 1987;146(1):32-40.
1987: J C Chambard; S Paris; G L'Allemain; Jacques Pouysségur
Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin.
Nature 1987;326(6115):800-3.
1986: I Magnaldo; G L'Allemain; J C Chambard; Michel Moenner; Denis Barritault; Jacques Pouysségur
The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.
The Journal of biological chemistry 1986;261(36):16916-22.
1986: A E Lagarde; Jacques Pouysségur
The Na+:H+ antiport in cancer.
Cancer biochemistry biophysics 1986;9(1):1-14.
1986: G L'Allemain; S Paris; I Magnaldo; Jacques Pouysségur
Alpha-thrombin-induced inositol phosphate formation in G0-arrested and cycling hamster lung fibroblasts: evidence for a protein kinase C-mediated desensitization response.
Journal of cellular physiology 1986;129(2):167-74.
1985: Ellen Van Obberghen-Schilling; J C Chambard; S Paris; G L'Allemain; Jacques Pouysségur
alpha-Thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation.
The EMBO journal 1985;4(11):2927-32.
1985: A E Lagarde; D E Renwick; A J Franchi; Jacques Pouysségur
Genetic dissection of growth factor-mediated controls of cell proliferation as an approach to analyze the process of tumor progression.
Carcinogenesis; a comprehensive survey 1985;9():87-104.
1984: Jacques Pouysségur; C Sardet; A Franchi; G L'Allemain; S Paris
A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(15):4833-7.
1983: Ellen Van Obberghen-Schilling; R Pérez-Rodríguez; A Franchi; J C Chambard; Jacques Pouysségur
Analysis of growth factor "relaxation" in Chinese hamster lung fibroblasts required for tumoral expression.
Journal of cellular physiology 1983;115(2):123-30.
1982: Jacques Pouysségur; J C Chambard; A Franchi; S Paris; Ellen Van Obberghen-Schilling
Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(13):3935-9.
1982: Ellen Van Obberghen-Schilling; R Pérez-Rodriguez; Jacques Pouysségur
Hirudin, a probe to analyze the growth-promoting activity of thrombin in fibroblasts; reevaluation of the temporal action of competence factors.
Biochemical and biophysical research communications 1982;106(1):79-86.
1981: R Pérez-Rodriguez; J C Chambard; Ellen Van Obberghen-Schilling; A Franchi; Jacques Pouysségur
Emergence of hamster fibroblast tumors in nude mice--evidence for in vivo selection leading to loss of growth factor requirement.
Journal of cellular physiology 1981;109(3):387-96.