James Powers

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Shen Aimee; Lupardus Patrick J; Albrow Victoria E; Guzzetta Andrew; Powers James C; Garcia K Christopher; Bogyo Matthew
Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Liz Márcia A; Fleming Carolina E; Nunes Ana F; Almeida Maria R; Mar Fernando M; Choe Youngchool; Craik Charles S; Powers James C; Bogyo Matthew; Sousa Mónica M
Substrate specificity of transthyretin: identification of natural substrates in the nervous system.
Qian Jin; Cuerrier Dominic; Davies Peter L; Li Zhaozhao; Powers James C; Campbell Robert L
Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions.

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All Publications

2009: Shen Aimee; Lupardus Patrick J; Albrow Victoria E; Guzzetta Andrew; Powers James C; Garcia K Christopher; Bogyo Matthew
Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Nature chemical biology 2009;5(7):469-78.
2009: Liz Márcia A; Fleming Carolina E; Nunes Ana F; Almeida Maria R; Mar Fernando M; Choe Youngchool; Craik Charles S; Powers James C; Bogyo Matthew; Sousa Mónica M
Substrate specificity of transthyretin: identification of natural substrates in the nervous system.
The Biochemical journal 2009;419(2):467-74.
2008: Qian Jin; Cuerrier Dominic; Davies Peter L; Li Zhaozhao; Powers James C; Campbell Robert L
Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions.
Journal of medicinal chemistry 2008;51(17):5264-70.
2008: Götz Marion G; James Karen Ellis; Hansell Elizabeth; Dvorák Jan; Seshaadri Amritha; Sojka Daniel; Kopácek Petr; McKerrow James H; Caffrey Conor R; Powers James C
Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens.
Journal of medicinal chemistry 2008;51(9):2816-32.
2008: Arastu-Kapur Shirin; Ponder Elizabeth L; Fonovic Ursa Pecar; Yeoh Sharon; Yuan Fang; Fonovic Marko; Grainger Munira; Phillips Carolyn I; Powers James C; Bogyo Matthew
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.
Nature chemical biology 2008;4(3):203-13.
2007: Buccafusco Jerry J; Powers James C; Hernandez Maria A; Prendergast Mark A; Terry Alvin V; Jonnala Ramamohana R
MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition.
Neurochemical research 2007;32(7):1224-37.
2007: Lee Ting-Wai; Cherney Maia M; Liu Jie; James Karen Ellis; Powers James C; Eltis Lindsay D; James Michael N G
Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase.
Journal of molecular biology 2007;366(3):916-32.
2006: Ekici Ozlem Dogan; Li Zhao Zhao; Campbell Amy J; James Karen Ellis; Asgian Juliana L; Mikolajczyk Jowita; Salvesen Guy S; Ganesan Rajkumar; Jelakovic Stjepan; Grütter Markus G; Powers James C
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
Journal of medicinal chemistry 2006;49(19):5728-49.
2006: Ganesan Rajkumar; Jelakovic Stjepan; Campbell Amy J; Li Zhao Zhao; Asgian Juliana L; Powers James C; Grütter Markus G
Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors.
Biochemistry 2006;45(30):9059-67.
2005: Lee Ting-Wai; Cherney Maia M; Huitema Carly; Liu Jie; James Karen Ellis; Powers James C; Eltis Lindsay D; James Michael N G
Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide.
Journal of molecular biology 2005;353(5):1137-51.
2005: Jakobsen Rasmus Kragh; Ono Shin; Powers James C; DeLotto Robert
Fluorescently labeled inhibitors detect localized serine protease activities in Drosophila melanogaster pole cells, embryos, and ovarian egg chambers.
Histochemistry and cell biology 2005;123(1):51-60.
2004: Götz Marion G; Caffrey Conor R; Hansell Elizabeth; McKerrow James H; Powers James C
Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases.
Bioorganic & medicinal chemistry 2004;12(19):5203-11.
2004: Kam Chih-Min; Götz Marion G; Koot Gretchen; McGuire Michael; Thiele Dwain; Hudig Dorothy; Powers James C
Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).
Archives of biochemistry and biophysics 2004;427(2):123-34.
2004: Zeeuwen Patrick L J M; van Vlijmen-Willems Ivonne M J J; Olthuis Diana; Johansen Harald T; Hitomi Kiyotaka; Hara-Nishimura Ikuko; Powers James C; James Karen E; op den Camp Huub J; Lemmens Rob; Schalkwijk Joost
Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice.
Human molecular genetics 2004;13(10):1069-79.
2004: Ekici Ozlem Dogan; Götz Marion G; James Karen Ellis; Li Zhao Zhao; Rukamp Brian J; Asgian Juliana L; Caffrey Conor R; Hansell Elizabeth; Dvorák Jan; McKerrow James H; Potempa Jan; Travis James; Mikolajczyk Jowita; Salvesen Guy S; Powers James C
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.
Journal of medicinal chemistry 2004;47(8):1889-92.
2004: James Karen Ellis; Asgian Juliana L; Li Zhao Zhao; Ekici Ozlem Dogan; Rubin John R; Mikolajczyk Jowita; Salvesen Guy S; Powers James C
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8.
Journal of medicinal chemistry 2004;47(6):1553-74.
2004: Wang Min Sheng; Davis Albert A; Culver Deborah G; Wang Qinbo; Powers James C; Glass Jonathan D
Calpain inhibition protects against Taxol-induced sensory neuropathy.
Brain : a journal of neurology 2004;127(Pt 3):671-9.
2004: Rukamp Brian J; Kam Chih Min; Natarajan Sudah; Bolton Brad W; Smyth Mark J; Kelly Janice M; Powers James C
Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates.
Archives of biochemistry and biophysics 2004;422(1):9-22.
2003: James Karen Ellis; Götz Marion G; Caffrey Conor R; Hansell Elizabeth; Carter Wendy; Barrett Alan J; McKerrow James H; Powers James C
Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases).
Biological chemistry 2003;384(12):1613-8.
2002: Powers James C; Asgian Juliana L; Ekici Ozlem Dogan; James Karen Ellis
Irreversible inhibitors of serine, cysteine, and threonine proteases.
Chemical reviews 2002;102(12):4639-750.
2002: Asgian Juliana L; James Karen Ellis; Li Zhao Zhao; Carter Wendy; Barrett Alan J; Mikolajczyk Jowita; Salvesen Guy S; Powers James C
Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases.
Journal of medicinal chemistry 2002;45(23):4958-60.
2002: Krauser Joel A; Potempa Jan; Travis James; Powers James C
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.
Biological chemistry 2002;383(7-8):1193-8.
2002: Tran Tinh V; Ellis Karen A; Kam Chih Min; Hudig Dorothy; Powers James C
Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity.
Archives of biochemistry and biophysics 2002;403(2):160-70.
2001: Gorrini M; Lupi A; Viglio S; Pamparana F; Cetta G; Iadarola P; Powers J C; Luisetti M
Inhibition of human neutrophil elastase by erythromycin and flurythromycin, two macrolide antibiotics.
American journal of respiratory cell and molecular biology 2001;25(4):492-9.
2001: Gütschow M; Powers J C
2-Alkylthio-4-oxo-3-quinazolineacetonitriles and analogous thieno[3,2-d]pyrimidineacetonitriles: reaction with thiols via trapped thioimidates.
The Journal of organic chemistry 2001;66(13):4723-7.
2001: Korver G E; Kam C M; Powers J C; Hudig D
Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I.
International immunopharmacology 2001;1(1):21-32.
2000: Powers J C; Kam C M; Ricketts K M; Casillas R P
Cutaneous protease activity in the mouse ear vesicant model.
Journal of applied toxicology : JAT 2000;20 Suppl 1():S177-82.
2000: Morty R E; Troeberg L; Powers J C; Ono S; Lonsdale-Eccles J D; Coetzer T H
Characterisation of the antitrypanosomal activity of peptidyl alpha-aminoalkyl phosphonate diphenyl esters.
Biochemical pharmacology 2000;60(10):1497-504.
2000: Harriman J F; Waters-Williams S; Chu D L; Powers J C; Schnellmann R G
Efficacy of novel calpain inhibitors in preventing renal cell death.
The Journal of pharmacology and experimental therapeutics 2000;294(3):1083-7.
2000: Kam C M; Hudig D; Powers J C
Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.
Biochimica et biophysica acta 2000;1477(1-2):307-23.
1999: Edwards K M; Kam C M; Powers J C; Trapani J A
The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes.
The Journal of biological chemistry 1999;274(43):30468-73.
1999: Henkel M K; Pott G; Henkel A W; Juliano L; Kam C M; Powers J C; Franzusoff A
Endocytic delivery of intramolecularly quenched substrates and inhibitors to the intracellular yeast Kex2 protease1.
The Biochemical journal 1999;341 ( Pt 2)():445-52.
1999: Caputo A; Parrish J C; James M N; Powers J C; Bleackley R C
Electrostatic reversal of serine proteinase substrate specificity.
Proteins 1999;35(4):415-24.
1998: Presnell S R; Patil G S; Mura C; Jude K M; Conley J M; Bertrand J A; Kam C M; Powers J C; Williams L D
Oxyanion-mediated inhibition of serine proteases.
Biochemistry 1998;37(48):17068-81.
1998: Ni L M; Powers J C
Synthesis and kinetic studies of an amidine-containing phosphonofluoridate: a novel potent inhibitor of trypsin-like enzymes.
Bioorganic & medicinal chemistry 1998;6(10):1767-73.
1998: Bryson H; Bunning R A; Feltell R; Kam C M; Kerrigan J; Powers J C; Buttle D J
A serine proteinase inactivator inhibits chondrocyte-mediated cartilage proteoglycan breakdown occurring in response to proinflammatory cytokines.
Archives of biochemistry and biophysics 1998;355(1):15-25.
1998: Jackson D S; Fraser S A; Ni L M; Kam C M; Winkler U; Johnson D A; Froelich C J; Hudig D; Powers J C
Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.
Journal of medicinal chemistry 1998;41(13):2289-301.
1998: Woodard S L; Fraser S A; Winkler U; Jackson D S; Kam C M; Powers J C; Hudig D
Purification and characterization of lymphocyte chymase I, a granzyme implicated in perforin-mediated lysis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4988-93.
1998: Xia Z; Kam C M; Huang C; Powers J C; Mandle R J; Stevens R L; Lieberman J
Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system.
Biochemical and biophysical research communications 1998;243(2):384-9.
1997: Orlowski M; Cardozo C; Eleuteri A M; Kohanski R; Kam C M; Powers J C
Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes).
Biochemistry 1997;36(45):13946-53.
1997: Abuelyaman A S; Jackson D S; Hudig D; Woodard S L; Powers J C
Synthesis and kinetic studies of diphenyl 1-(N-peptidylamino)alkanephosphonate esters and their biotinylated derivatives as inhibitors of serine proteases and probes for lymphocyte granzymes.
Archives of biochemistry and biophysics 1997;344(2):271-80.
1997: Beresford P J; Kam C M; Powers J C; Lieberman J
Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9285-90.
1997: Ewoldt G R; Smyth M J; Darcy P K; Harris J L; Craik C S; Horowitz B; Woodard S L; Powers J C; Hudig D
P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4574-83.
1996: Hof P; Mayr I; Huber R; Korzus E; Potempa J; Travis J; Powers J C; Bode W
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities.
The EMBO journal 1996;15(20):5481-91.
1996: Palencia D D; Garner D L; Hudig D; Holcombe D W; Burner C A; Redelman D; Fernandez G C; Abuelyaman A S; Kam C M; Powers J C
Determination of activable proacrosin/acrosin in bovine sperm using an irreversible isocoumarin serine protease inhibitor.
Biology of reproduction 1996;55(3):536-42.
1996: Li Z; Ortega-Vilain A C; Patil G S; Chu D L; Foreman J E; Eveleth D D; Powers J C
Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases.
Journal of medicinal chemistry 1996;39(20):4089-98.
1996: Winkler U; Allison N J; Woodard S L; Gault R A; Ewoldt G R; Kam C M; Abuelyaman A; Powers J C; Hudig D
Characterization, application and potential uses of biotin-tagged inhibitors for lymphocyte serine proteases (granzymes).
Molecular immunology 1996;33(7-8):615-23.
1996: Bertrand J A; Oleksyszyn J; Kam C M; Boduszek B; Presnell S; Plaskon R R; Suddath F L; Powers J C; Williams L D
Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
Biochemistry 1996;35(10):3147-55.
1996: Kerrigan J E; Powers J C; VanDerveer D
4-Chloro-7-(iodoacetyl)amino-3-methoxy-isocoumarin.
Acta crystallographica. Section C, Crystal structure communications 1996;52 ( Pt 2)():451-3.
1996: Starks K M; Ortega-Vilain A C; Buccafusco J J; Powers J C
Novel pyridinium derivatives as inhibitors for acetylcholinesterase.
Journal of enzyme inhibition 1996;10(1):27-45.
1995: Jackson D S; Brown A D; Schaeper R J; Powers J C
A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase.
Archives of biochemistry and biophysics 1995;323(1):108-14.
1995: Brown A D; Powers J C
Rates of thrombin acylation and deacylation upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylating agents.
Bioorganic & medicinal chemistry 1995;3(8):1091-7.
1995: Bartus R T; Elliott P J; Hayward N J; Dean R L; Harbeson S; Straub J A; Li Z; Powers J C
Calpain as a novel target for treating acute neurodegenerative disorders.
Neurological research 1995;17(4):249-58.
1995: Grams F; Reinemer P; Powers J C; Kleine T; Pieper M; Tschesche H; Huber R; Bode W
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
European journal of biochemistry / FEBS 1995;228(3):830-41.
1995: Kam C M; Hernandez M A; Patil G S; Ueda T; Simmons W H; Braganza V J; Powers J C
Mammalian tissue trypsin-like enzymes: substrate specificity and inhibitory potency of substituted isocoumarin mechanism-based inhibitors, benzamidine derivatives, and arginine fluoroalkyl ketone transition-state inhibitors.
Archives of biochemistry and biophysics 1995;316(2):808-14.
1995: Kerrigan J E; Oleksyszyn J; Kam C M; Selzler J; Powers J C
Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency.
Journal of medicinal chemistry 1995;38(3):544-52.
1995: Odake S; Kam C M; Powers J C
Inhibition of thrombin by arginine-containing peptide chloromethyl ketones and bis chloromethyl ketone-albumin conjugates.
Journal of enzyme inhibition 1995;9(1):17-27.
1995: Powers J C; Kam C M
Peptide thioester substrates for serine peptidases and metalloendopeptidases.
Methods in enzymology 1995;248():3-18.
1994: Woodard S L; Jackson D S; Abuelyaman A S; Powers J C; Winkler U; Hudig D
Chymase-directed serine protease inhibitor that reacts with a single 30-kDa granzyme and blocks NK-mediated cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):5016-25.
1994: Boduszek B; Oleksyszyn J; Kam C M; Selzler J; Smith R E; Powers J C
Dipeptide phosphonates as inhibitors of dipeptidyl peptidase IV.
Journal of medicinal chemistry 1994;37(23):3969-76.
1994: Abuelyaman A S; Hudig D; Woodard S L; Powers J C
Fluorescent derivatives of diphenyl [1-(N-peptidylamino)alkyl]phosphonate esters: synthesis and use in the inhibition and cellular localization of serine proteases.
Bioconjugate chemistry 1994;5(5):400-5.
1994: Caputo A; James M N; Powers J C; Hudig D; Bleackley R C
Conversion of the substrate specificity of mouse proteinase granzyme B.
Nature structural biology 1994;1(6):364-7.
1994: Kam C M; Kerrigan J E; Plaskon R R; Duffy E J; Lollar P; Suddath F L; Powers J C
Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency.
Journal of medicinal chemistry 1994;37(9):1298-306.
1994: Oleksyszyn J; Boduszek B; Kam C M; Powers J C
Novel amidine-containing peptidyl phosphonates as irreversible inhibitors for blood coagulation and related serine proteases.
Journal of medicinal chemistry 1994;37(2):226-31.
1994: Powers J C; Kam C M
Isocoumarin inhibitors of serine peptidases.
Methods in enzymology 1994;244():442-57.
1994: Oleksyszyn J; Powers J C
Amino acid and peptide phosphonate derivatives as specific inhibitors of serine peptidases.
Methods in enzymology 1994;244():423-41.
1994: Boduszek B; Brown A D; Powers J C
alpha-Aminoalkylphosphonate di(chlorophenyl) esters as inhibitors of serine proteases.
Journal of enzyme inhibition 1994;8(3):147-58.
1993: Smyth M J; Sayers T J; Wiltrout T; Powers J C; Trapani J A
Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6195-205.
1993: Kam C M; Abuelyaman A S; Li Z; Hudig D; Powers J C
Biotinylated isocoumarins, new inhibitors and reagents for detection, localization, and isolation of serine proteases.
Bioconjugate chemistry 1993;4(6):560-7.
1993: Li Z; Patil G S; Golubski Z E; Hori H; Tehrani K; Foreman J E; Eveleth D D; Bartus R T; Powers J C
Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases.
Journal of medicinal chemistry 1993;36(22):3472-80.
1993: Plaskon R R; Kam C M; Kerrigan J E; Burgess E M; Powers J C; Suddath F L
Inhibition of porcine pancreatic elastase by 7-substituted 4-chloro-3-ethoxyisocoumarins: structural characteristics of modeled noncovalent complexes relate to the measured inhibition kinetics.
Archives of biochemistry and biophysics 1993;300(2):588-97.
1993: Powers J C; Odake S; Oleksyszyn J; Hori H; Ueda T; Boduszek B; Kam C
Proteases--structures, mechanism and inhibitors.
Agents and actions. Supplements 1993;42():3-18.
1993: Dolman K M; van de Wiel B A; Kam C M; Kerrigan J E; Hack C E; von dem Borne A E; Powers J C; Goldschmeding R
Proteinase 3: substrate specificity and possible pathogenetic effect of Wegener's granulomatosis autoantibodies (c-ANCA) by dysregulation of the enzyme.
Advances in experimental medicine and biology 1993;336():55-60.
1993: Bihovsky R; Powers J C; Kam C M; Walton R; Loewi R C
Further evidence for the importance of free carboxylate in epoxysuccinate inhibitors of thiol proteases.
Journal of enzyme inhibition 1993;7(1):15-25.
1992: Shi L; Kam C M; Powers J C; Aebersold R; Greenberg A H
Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.
The Journal of experimental medicine 1992;176(6):1521-9.
1992: Dolman K M; van de Wiel B A; Kam C M; Abbink J J; Hack C E; Sonnenberg A; Powers J C; von dem Borne A E; Goldschmeding R
Determination of proteinase 3-alpha 1-antitrypsin complexes in inflammatory fluids.
FEBS letters 1992;314(2):117-21.
1992: Smyth M J; Wiltrout T; Trapani J A; Ottaway K S; Sowder R; Henderson L E; Kam C M; Powers J C; Young H A; Sayers T J
Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia.
The Journal of biological chemistry 1992;267(34):24418-25.
1992: Vinitsky A; Michaud C; Powers J C; Orlowski M
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex.
Biochemistry 1992;31(39):9421-8.
1992: Kam C M; Oglesby T J; Pangburn M K; Volanakis J E; Powers J C
Substituted isocoumarins as inhibitors of complement serine proteases.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):163-8.
1992: Ewoldt G R; Winkler U; Powers J C; Hudig D
Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin.
Molecular immunology 1992;29(6):713-21.
1992: Zembower D E; Kam C M; Powers J C; Zalkow L H
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Journal of medicinal chemistry 1992;35(9):1597-605.
1992: Plaskon R R; Kam C M; Burgess E M; Powers J C; Suddath F L
Michaelis complexes of porcine pancreatic elastase with 7-[(alkylcarbamoyl)amino]-4-chloro-3-ethoxyisocoumarins: translational sampling of inhibitor position and kinetic measurements.
Proteins 1992;13(2):141-51.
1992: Hernandez M A; Powers J C; Glinski J; Oleksyszyn J; Vijayalakshmi J; Meyer E F
Effect of the 7-amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: a 1.85-A X-ray structure of the complex between porcine pancreatic elastase and 7-[(N-tosylphenylalanyl)amino]-4-chloro-3- methoxyisocoumarin.
Journal of medicinal chemistry 1992;35(6):1121-9.
1992: Kam C M; Kerrigan J E; Dolman K M; Goldschmeding R; Von dem Borne A E; Powers J C
Substrate and inhibitor studies on proteinase 3.
FEBS letters 1992;297(1-2):119-23.
1992: Powers J C; Odake S; Ueda T; Hudig D; Graves H C; Kamarei M; Kam C M
Synthetic substrates and inhibitors for serine proteases from lymphocytes, mast cells, semen, and blood.
Agents and actions. Supplements 1992;38 ( Pt 2)():128-35.
1991: Hudig D; Allison N J; Pickett T M; Winkler U; Kam C M; Powers J C
The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1360-8.
1991: Odake S; Kam C M; Narasimhan L; Poe M; Blake J T; Krahenbuhl O; Tschopp J; Powers J C
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
Biochemistry 1991;30(8):2217-27.
1991: Vijayalakshmi J; Meyer E F; Kam C M; Powers J C
Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex.
Biochemistry 1991;30(8):2175-83.
1991: Oleksyszyn J; Powers J C
Irreversible inhibition of serine proteases by peptide derivatives of (alpha-aminoalkyl)phosphonate diphenyl esters.
Biochemistry 1991;30(2):485-93.
1990: Kam C M; Vlasuk G P; Smith D E; Arcuri K E; Powers J C
Thioester chromogenic substrates for human factor VIIa: substituted isocoumarins are inhibitors of factor VIIa and in vitro anticoagulants.
Thrombosis and haemostasis 1990;64(1):133-7.
1990: Oweida S W; Ku D N; Lumsden A B; Kam C M; Powers J C
In vivo determination of the anticoagulant effect of a substituted isocoumarin (ACITIC).
Thrombosis research 1990;58(2):191-7.
1990: Powers J C; Oleksyszyn J; Narasimhan S L; Kam C M
Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.
Biochemistry 1990;29(12):3108-18.
1990: Ueda T; Kam C M; Powers J C
The synthesis of arginylfluoroalkanes, their inhibition of trypsin and blood-coagulation serine proteinases and their anticoagulant activity.
The Biochemical journal 1990;265(2):539-45.
1989: Hudig D; Allison N J; Kam C M; Powers J C
Selective isocoumarin serine protease inhibitors block RNK-16 lymphocyte granule-mediated cytolysis.
Molecular immunology 1989;26(8):793-8.
1989: Lucey E C; Stone P J; Powers J C; Snider G L
Amelioration of human neutrophil elastase-induced emphysema in hamsters by pretreatment with an oligopeptide chloromethyl ketone.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1989;2(5):421-7.
1989: Oleksyszyn J; Powers J C
Irreversible inhibition of serine proteases by peptidyl derivatives of alpha-aminoalkylphosphonate diphenyl esters.
Biochemical and biophysical research communications 1989;161(1):143-9.
1989: Vlasak R; Muster T; Lauro A M; Powers J C; Palese P
Influenza C virus esterase: analysis of catalytic site, inhibition, and possible function.
Journal of virology 1989;63(5):2056-62.
1989: Bode W; Meyer E; Powers J C
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
Biochemistry 1989;28(5):1951-63.
1989: Orlowski M; Lesser M; Ayala J; Lasdun A; Kam C M; Powers J C
Substrate specificity and inhibitors of a capillary injury-related protease from sheep lung lymph.
Archives of biochemistry and biophysics 1989;269(1):125-36.
1989: Powers J C; Kam C M; Narasimhan L; Oleksyszyn J; Hernandez M A; Ueda T
Mechanism-based isocoumarin inhibitors for serine proteases: use of active site structure and substrate specificity in inhibitor design.
Journal of cellular biochemistry 1989;39(1):33-46.
1988: Zunino S J; Allison N J; Kam C M; Powers J C; Hudig D
Localization, implications for function, and gene expression of chymotrypsin-like proteinases of cytotoxic RNK-16 lymphocytes.
Biochimica et biophysica acta 1988;967(3):331-40.
1988: Kam C M; Fujikawa K; Powers J C
Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: new anticoagulants.
Biochemistry 1988;27(7):2547-57.
1987: Hudig D; Gregg N J; Kam C M; Powers J C
Lymphocyte granule-mediated cytolysis requires serine protease activity.
Biochemical and biophysical research communications 1987;149(3):882-8.
1987: Stein R L; Strimpler A M; Hori H; Powers J C
Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.
Biochemistry 1987;26(5):1301-5.
1987: Kam C M; McRae B J; Harper J W; Niemann M A; Volanakis J E; Powers J C
Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates.
The Journal of biological chemistry 1987;262(8):3444-51.
1987: Stein R L; Strimpler A M; Hori H; Powers J C
Catalysis by human leukocyte elastase: proton inventory as a mechanistic probe.
Biochemistry 1987;26(5):1305-14.
1987: Powers J C; Bengali Z H
Elastase inhibitors for treatment of emphysema. Approaches to synthesis and biological evaluation.
Journal of enzyme inhibition 1987;1(4):311-9.
1986: Powers J C; Bengali Z H
Elastase inhibitors for treatment of emphysema. Approaches to synthesis and biological evaluation.
The American review of respiratory disease 1986;134(5):1097-100.
1985: Harper J W; Powers J C
Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors.
Biochemistry 1985;24(25):7200-13.
1985: Vencill C F; Rasnick D; Crumley K V; Nishino N; Powers J C
Clostridium histolyticum collagenase: development of new thio ester, fluorogenic, and depsipeptide substrates and new inhibitors.
Biochemistry 1985;24(13):3149-57.
1985: Tanaka T; Minematsu Y; Reilly C F; Travis J; Powers J C
Human leukocyte cathepsin G. Subsite mapping with 4-nitroanilides, chemical modification, and effect of possible cofactors.
Biochemistry 1985;24(8):2040-7.
1985: Powers J C; Tanaka T; Harper J W; Minematsu Y; Barker L; Lincoln D; Crumley K V; Fraki J E; Schechter N M; Lazarus G G
Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors.
Biochemistry 1985;24(8):2048-58.
1985: Harper J W; Hemmi K; Powers J C
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor.
Biochemistry 1985;24(8):1831-41.
1985: Hemmi K; Harper J W; Powers J C
Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A alpha, and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones.
Biochemistry 1985;24(8):1841-8.
1984: Cook R R; McRae B J; Powers J C
Kinetics of hydrolysis of peptide thioester derivatives of arginine by human and bovine thrombins.
Archives of biochemistry and biophysics 1984;234(1):82-8.
1984: Reilly C F; Fukunaga Y; Powers J C; Travis J
Effect of neutrophil cathepsin G on elastin degradation by neutrophil elastase.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1984;365(9):1131-5.
1984: Powers J C; McRae B J; Tanaka T; Cho K; Cook R R
Peptide thioesters and 4-nitroanilides as substrates for porcine pancreatic kallikrein.
The Biochemical journal 1984;220(2):569-73.
1984: Harper J W; Cook R R; Roberts C J; McLaughlin B J; Powers J C
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
Biochemistry 1984;23(13):2995-3002.
1984: Rush R S; Mitas M; Powers J C; Tanaka T; Hersh L B
Fluorogenic substrates for the enkephalin-degrading neutral endopeptidase (Enkephalinase).
Archives of biochemistry and biophysics 1984;231(2):390-9.
1984: Powers J C; Boone R; Carroll D L; Gupton B F; Kam C M; Nishino N; Sakamoto M; Tuhy P M
Reaction of azapeptides with human leukocyte elastase and porcine pancreatic elastase. New inhibitors and active site titrants.
The Journal of biological chemistry 1984;259(7):4288-94.
1984: Gupton B F; Carroll D L; Tuhy P M; Kam C M; Powers J C
Reaction of azapeptides with chymotrypsin-like enzymes. New inhibitors and active site titrants for chymotrypsin A alpha, subtilisin BPN', subtilisin Carlsberg, and human leukocyte cathepsin G.
The Journal of biological chemistry 1984;259(7):4279-87.
1984: Cho K; Tanaka T; Cook R R; Kisiel W; Fujikawa K; Kurachi K; Powers J C
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
Biochemistry 1984;23(4):644-50.
1983: Cook R R; Powers J C
Benzyl p-guanidinothiobenzoate hydrochloride, a new active-site titrant for trypsin and trypsin-like enzymes.
The Biochemical journal 1983;215(2):287-94.
1983: Tanaka T; McRae B J; Cho K; Cook R; Fraki J E; Johnson D A; Powers J C
Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.
The Journal of biological chemistry 1983;258(22):13552-7.
1983: Castillo M J; Kurachi K; Nishino N; Ohkubo I; Powers J C
Reactivity of bovine blood coagulation factor IXa beta, factor Xa beta, and factor XIa toward fluorogenic peptides containing the activation site sequences of bovine factor IX and factor X.
Biochemistry 1983;22(5):1021-9.
1983: Powers J C
Synthetic elastase inhibitors: prospects for use in the treatment of emphysema.
The American review of respiratory disease 1983;127(2):S54-8.
1983: Hersh L B; Gafford J T; Powers J C; Tanaka T; Erdös E G
Novel substrates for angiotensin I converting enzyme.
Biochemical and biophysical research communications 1983;110(2):654-9.
1982: Teshima T; Griffin J C; Powers J C
A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates.
The Journal of biological chemistry 1982;257(9):5085-91.
1982: Yoshimura T; Barker L N; Powers J C
Specificity and reactivity of human leukocyte elastase, porcine pancreatic elastase, human granulocyte cathepsin G, and bovine pancreatic chymotrypsin with arylsulfonyl fluorides. Discovery of a new series of potent and specific irreversible elastase inhibitors.
The Journal of biological chemistry 1982;257(9):5077-84.
1981: Bush G A; Yoshida N; Lively M O; Mathur B P; Rust M; Moran T F; Powers J C
Ion beam tritium labeling of proteins and peptides.
The Journal of biological chemistry 1981;256(23):12213-21.
1981: Harper J W; Ramirez G; Powers J C
Reaction of peptide thiobenzyl esters with mammalian chymotrypsinlike enzymes: a sensitive assay method.
Analytical biochemistry 1981;118(2):382-7.
1981: McRae B J; Kurachi K; Heimark R L; Fujikawa K; Davie E W; Powers J C
Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates.
Biochemistry 1981;20(25):7196-206.
1981: Ip M P; Kleinerman J; Ranga V; Sorensen J; Powers J C
The effects of small doses of oligopeptide elastase inhibitors on elastase-induced emphysema in hamsters: a dose-response study.
The American review of respiratory disease 1981;124(6):714-7.
1981: McRae B J; Lin T Y; Powers J C
Mapping the substrate binding site of human C1r and C1s with peptide thioesters. Development of new sensitive substrates.
The Journal of biological chemistry 1981;256(23):12362-6.
1981: Ranga V; Kleinerman J; Ip M P; Sorensen J; Powers J C
Effects of oligopeptide chloromethylketone administered after elastase: renal toxicity and lack of prevention of experimental emphysema.
The American review of respiratory disease 1981;124(5):613-8.
1981: Stone P J; Lucey E C; Calore J D; Snider G L; Franzblau C; Castillo M J; Powers J C
The moderation of elastase-induced emphysema in the hamster by intratracheal pretreatment or post-treatment with succinyl alanyl alanyl prolyl valine chloromethyl ketone.
The American review of respiratory disease 1981;124(1):56-9.
1981: Yasutake A; Powers J C
Reactivity of human leukocyte elastase and porcine pancreatic elastase toward peptide 4-nitroanilides containing model desmosine residues. Evidence that human leukocyte elastase is selective for cross-linked regions of elastin.
Biochemistry 1981;20(13):3675-9.
1980: Yoshida N; Everitt M T; Neurath H; Woodbury R G; Powers J C
Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G.
Biochemistry 1980;19(25):5799-804.
1980: Lively M O; Bush G A; Mathur B P; Moran T F; Powers J C
Tritium labeling of thermolysin, elastase, and ribonuclease by exposure to tritium gas at low pressure.
Archives of biochemistry and biophysics 1980;204(2):589-99.
1980: Korant B D; Lively M O; Powers J C
Limited proteolysis and viral replication.
Biochemical Society transactions 1980;8(4):417-9.
1980: McRae B; Nakajima K; Travis J; Powers J C
Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of alpha 1-protease inhibitor (alpha 1-antitrypsin).
Biochemistry 1980;19(17):3973-8.
1980: Nishino N; Powers J C
Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand.
The Journal of biological chemistry 1980;255(8):3482-6.
1980: Mumford R A; Strauss A W; Powers J C; Pierzchala P A; Nishino N; Zimmerman M
A zinc metalloendopeptidase associated with dog pancreatic membranes.
The Journal of biological chemistry 1980;255(6):2227-30.
1980: Kleinerman J; Ranga V; Rynbrandt D; Sorensen J; Powers J C
The effect of the specific elastase inhibitor, alanyl alanyl prolyl alanine chloromethylketone, on elastase-induced emphysema.
The American review of respiratory disease 1980;121(2):381-7.
1980: Zimmerman M; Ashe B M; Alberts A W; Pierzchala P A; Powers J C; Nishino N; Strauss A W; Mumford R A
Protease activities present in dog pancreatic membranes that process human pre-placental lactogen.
Annals of the New York Academy of Sciences 1980;343():405-14.
1980: Korant B D; Chow N L; Lively M O; Powers J C
Proteolytic events in replication of animal viruses.
Annals of the New York Academy of Sciences 1980;343():304-18.
1979: Castillo M J; Nakajima K; Zimmerman M; Powers J C
Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases.
Analytical biochemistry 1979;99(1):53-64.
1979: Nishino N; Powers J C
Design of potent reversible inhibitors for thermolysin. Peptides containing zinc coordinating ligands and their use in affinity chromatography.
Biochemistry 1979;18(20):4340-7.
1979: Kam C M; Nishino N; Powers J C
Inhibition of thermolysin and carboxypeptidase A by phosphoramidates.
Biochemistry 1979;18(14):3032-8.
1979: Korant B; Chow N; Lively M; Powers J
Virus-specified protease in poliovirus-infected HeLa cells.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(6):2992-5.
1979: Nakajima K; Powers J C; Ashe B M; Zimmerman M
Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.
The Journal of biological chemistry 1979;254(10):4027-32.
1979: Martodam R R; Twumasi D Y; Liener I E; Powers J C; Nishino N; Krejcarek G
Albumin microspheres as carrier of an inhibitor of leukocyte elastase: potential therapeutic agent for emphysema.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(5):2128-32.
1979: Lively M O; Moran T F; Powers J C
Low pressure tritiation of proteins.
The Journal of biological chemistry 1979;254(2):262-4.
1979: Travis J; Giles P J; Porcelli L; Reilly C F; Baugh R; Powers J
Human leucocyte elastase and cathepsin G: structural and functional characteristics.
Ciba Foundation symposium 1979;(75):51-68.
1978: Rasnick D; Powers J C
Active site directed irreversible inhibition of thermolysin.
Biochemistry 1978;17(21):4363-9.
1978: Nishino N; Powers J C
Peptide hydroxamic acids as inhibitors of thermolysin.
Biochemistry 1978;17(14):2846-50.
1978: Lively M O; Powers J C
Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl fluorides.
Biochimica et biophysica acta 1978;525(1):171-9.
1977: Powers J C; Gupton B F; Harley A D; Nishino N; Whitley R J
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones.
Biochimica et biophysica acta 1977;485(1):156-66.
1977: Powers J C; Lively M O; Tippett J T
Inhibition of subtilisin BPN' with peptide chloromethyl ketones.
Biochimica et biophysica acta 1977;480(1):246-61.
1977: Powers J C; Gupton B F
Reaction of serine proteases with aza-amino acid and aza-peptide derivatives.
Methods in enzymology 1977;46():208-16.
1977: Powers J C
Reaction of serine proteases with halomethyl ketones.
Methods in enzymology 1977;46():197-208.
1977: Powers J C; Harley A D; Myers D V
Subsite specificity of porcine pepsin.
Advances in experimental medicine and biology 1977;95():141-57.
1976: Powers J C; Tuhy P M; Witter F
Modification of chymotrypsin with the specific cyanate reagent N-acetyl-p-cyanato-l-phenylalanine ethyl ester.
Biochimica et biophysica acta 1976;445(2):426-36.
1975: Powers J C; Carroll D L
Reaction of acyl carbazates with proteolytic enzymes.
Biochemical and biophysical research communications 1975;67(2):639-44.
1975: Powers J C; Carroll D L; Tuhy P M
Synthetic active site-directed inhibitors of elastolytic proteases.
Annals of the New York Academy of Sciences 1975;256():420-5.
1975: Tuhy P M; Powers J C
Inhibition of human leukocyte elastase by peptide chloromethyl ketones.
FEBS letters 1975;50(3):359-61.
1974: Powers J C; Baker B L; Brown J; Chelm B K
Inhibition of chymotrypsin A-alpha with N-acyl- and N-peptidyl-2-phenylethyl amines. Subsite binding free energies.
Journal of the American Chemical Society 1974;96(1):238-43.
1973: Powers J C; Tuhy P M
Active-site specific inhibitors of elastase.
Biochemistry 1973;12(23):4767-74.
1973: Kurachi K; Powers J C; Wilcox P E
Kinetics of the reaction of chymotrypsin A with peptide chloromethyl ketones in relation to its subsite specificity.
Biochemistry 1973;12(4):771-7.
1972: Powers J C; Tuhy P M
Active-site specific inhibitors of elastase.
Journal of the American Chemical Society 1972;94(8):6544-5.
1972: Robertus J D; Alden R A; Birktoft J J; Kraut J; Powers J C; Wilcox P E
An x-ray crystallographic study of the binding of peptide chloromethyl ketone inhibitors to subtilisin BPN'.
Biochemistry 1972;11(13):2439-49.
1972: Robillard G T; Powers J C; Wilcox P E
A chemical and crystallographic study of carbamyl-chymotrypsin A.
Biochemistry 1972;11(10):1773-84.
1972: Segal D M; Cohen C H; Davies D R; Powers J C; Wilcox P E
The stereochemistry of substrate binding to chymotrypsin A .
Cold Spring Harbor symposia on quantitative biology 1972;36():85-90.
1972: Kraut J; Robertus J D; Birktoft J J; Alden R A; Wilcox P E; Powers J C
The aromatic substrate binding site in subtilisin BPN' and its resemblance to chymotrypsin.
Cold Spring Harbor symposia on quantitative biology 1972;36():117-23.
1971: Segal D M; Powers J C; Cohen G H; Davies D R; Wilcox P E
Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors.
Biochemistry 1971;10(20):3728-38.
1970: Powers J C; Wilcox P E
Design and synthesis of inhibitors for crystallographic studies on the active site of chymotrypsin.
Journal of the American Chemical Society 1970;92(6):1782-3.

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