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Ian Poxton

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TOP 3
Prerna Vohra; Ian R Poxton
Induction of cytokines in a macrophage cell line by proteins of Clostridium difficile.
Prerna Vohra; Ian R Poxton
Comparison of toxin and spore production in clinically relevant strains of Clostridium difficile.
Ian R Poxton
Fidaxomicin: a new macrocyclic, RNA polymerase-inhibiting antibiotic for the treatment of Clostridium difficile infections.

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All Publications

2012: Prerna Vohra; Ian R Poxton
Induction of cytokines in a macrophage cell line by proteins of Clostridium difficile.
FEMS immunology and medical microbiology 2012;65(1):96-104.
2011: Prerna Vohra; Ian R Poxton
Comparison of toxin and spore production in clinically relevant strains of Clostridium difficile.
Microbiology (Reading, England) 2011;157(Pt 5):1343-53.
2010: Ian R Poxton
Fidaxomicin: a new macrocyclic, RNA polymerase-inhibiting antibiotic for the treatment of Clostridium difficile infections.
Future microbiology 2010;5(4):539-48.
2010: S Reddy; S Taori; Ian R Poxton
Changes in laboratory and clinical workload for Clostridium difficile infection from 2003 to 2007 in hospitals in Edinburgh.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2010;16(4):340-6.
2010: Surabhi K Taori; Val Hall; Ian R Poxton
Changes in antibiotic susceptibility and ribotypes in Clostridium difficile isolates from southern Scotland, 1979-2004.
Journal of medical microbiology 2010;59(Pt 3):338-44.
2010: D R Anuruddhika Dissanayake; TG Wijewardana; Gnana A Gunawardena; Ian R Poxton
Potential use of a liposome-encapsulated mixture of lipopolysaccharide core types (R1, R2, R3 and R4) of Escherichia coli in controlling colisepticaemia in chickens.
Journal of medical microbiology 2010;59(Pt 1):100-7.
2009: Mohammad Bahawi; John Stewart; Clett Erridge; Sheila Patrick; Ian R Poxton
Bacteroides fragilis signals through Toll-like receptor (TLR) 2 and not through TLR4.
Journal of medical microbiology 2009;58(Pt 8):1015-22.
2008: Patrizia Spigaglia; Fabrizio Barbanti; Paola Mastrantonio; Jon S Brazier; Frédéric Barbut; Michel Delmée; Ed Kuijper; Ian R Poxton
Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe.
Journal of medical microbiology 2008;57(Pt 6):784-9.
2008: Karla Sánchez-Hurtado; Ian R Poxton
Enhancement of the cytotoxic activity of Clostridium difficile toxin A by surface-associated antigens.
Journal of medical microbiology 2008;57(Pt 6):739-44.
2008: Karla Sánchez-Hurtado; Maria Corretge; Esvet Mutlu; Rowan McIlhagger; John M Starr; Ian R Poxton
Systemic antibody response to Clostridium difficile in colonized patients with and without symptoms and matched controls.
Journal of medical microbiology 2008;57(Pt 6):717-24.
2008: Ian R Poxton
Clostridium difficile.
Journal of medical microbiology 2008;57(Pt 6):683-4.
2007: Frédéric Barbut; P Mastrantonio; Michel Delmée; J Brazier; E Kuijper; Ian R Poxton
Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterisation of the isolates.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2007;13(11):1048-57.
2007: FG Nunn; RS Pirie; Bruce C McGorum; U Wernery; Ian R Poxton
Preliminary study of mucosal IgA in the equine small intestine: specific IgA in cases of acute grass sickness and controls.
Equine veterinary journal 2007;39(5):457-60.
2007: FG Nunn; RS Pirie; Bruce C McGorum; U Wernery; Ian R Poxton
Comparison of IgG antibody levels to Clostridium botulinum antigens between euthanased and surviving cases of chronic grass sickness.
Research in veterinary science 2007;83(1):82-4.
2007: Esvet Mutlu; Allison J Wroe; Karla Sanchez-Hurtado; Jon S Brazier; Ian R Poxton
Molecular characterization and antimicrobial susceptibility patterns of Clostridium difficile strains isolated from hospitals in south-east Scotland.
Journal of medical microbiology 2007;56(Pt 7):921-9.
2007: Ed J Kuijper; frederic barbut; Jon S Brazier; C Suetens; D Drudy; Camilla Wiuff; Hanna Pituch; P Reichert; F Schneider; A F Widmer; K E Olsen; F Allerberger; Daan W Notermans; Frédéric Barbut; Michel Delmée; Mark H Wilcox; A Pearson; B C Patel; Derek Brown; R Frei; T Akerlund; Ian R Poxton; P Tüll
Update of Clostridium difficile-associated disease due to PCR ribotype 027 in Europe.
Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin 2007;12(6):E1-2.
2007: Ann Heffron; Ian R Poxton
A PCR approach to determine the distribution of toxin genes in closely related Clostridium species: Clostridium botulinum type C and D neurotoxins and C2 toxin, and Clostridium novyi alpha toxin.
Journal of medical microbiology 2007;56(Pt 2):196-201.
2007: Clett Erridge; Olga L Moncayo-Nieto; Robert Morgan; Michelle Young; Ian R Poxton
Acinetobacter baumannii lipopolysaccharides are potent stimulators of human monocyte activation via Toll-like receptor 4 signalling.
Journal of medical microbiology 2007;56(Pt 2):165-71.
2006: Sonia J Wakelin; Ian Sabroe; Christopher D Gregory; Ian R Poxton; John L R Forsythe; O James Garden; Sarah E M Howie
"Dirty little secrets"--endotoxin contamination of recombinant proteins.
Immunology letters 2006;106(1):1-7.
2005: Ana Cerdeño-Tárraga; Sheila Patrick; Lisa Crossman; Garry Blakely; Valerie R Abratt; Nicola Lennard; Ian R Poxton; Brian I Duerden; Barbara Harris; Michael A Quail; Andrew Barron; Louise Clark; Craig Corton; Jon Doggett; Matthew T G Holden; Natasha Larke; Alexandra Line; Angela Lord; Halina Norbertczak; Doug Ormond; Claire Price; Ester Rabbinowitsch; John Woodward; Bart Barrell; Julian Parkhill
Extensive DNA inversions in the B. fragilis genome control variable gene expression.
Science (New York, N.Y.) 2005;307(5714):1463-5.
2005: Ian R Poxton
Molecular techniques in the diagnosis and management of infectious diseases: do they have a role in bacteriology?
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2005;14 Suppl 1():20-6.
2004: Richard J Gibbs; John Stewart; Ian R Poxton
The distribution of, and antibody response to, the core lipopolysaccharide region of Escherichia coli isolated from the faeces of healthy humans and cattle.
Journal of medical microbiology 2004;53(Pt 10):959-64.
2004: Clett Erridge; Alison Pridmore; Adrian Eley; John Stewart; Ian R Poxton
Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2.
Journal of medical microbiology 2004;53(Pt 8):735-40.
2004: FG Nunn; Thomas A Cave; Clare Knottenbelt; Ian R Poxton
Association between Key-Gaskell syndrome and infection by Clostridium botulinum type C/D.
The Veterinary record 2004;155(4):111-5.
2003: Lisa J Drummond; David G E Smith; Ian R Poxton
Effects of sub-MIC concentrations of antibiotics on growth of and toxin production by Clostridium difficile.
Journal of medical microbiology 2003;52(Pt 12):1033-8.
2003: John M Starr; Heather Martin; Jodie McCoubrey; Gavin Gibson; Ian R Poxton
Risk factors for Clostridium difficile colonisation and toxin production.
Age and ageing 2003;32(6):657-60.
2003: Frédéric Barbut; Michel Delmée; Jon S Brazier; Jean-Claude Petit; Ian R Poxton; Marjan Rupnik; Valérie Lalande; C Schneider; P Mastrantonio; R Alonso; E Kuipjer; M Tvede
A European survey of diagnostic methods and testing protocols for Clostridium difficile.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2003;9(10):989-96.
2003: Jodie McCoubrey; John Starr; Heather Martin; Ian R Poxton
Clostridium difficile in a geriatric unit: a prospective epidemiological study employing a novel S-layer typing method.
Journal of medical microbiology 2003;52(Pt 7):573-8.
2003: Clett Erridge; John Stewart; Ian R Poxton
Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.
The Journal of experimental medicine 2003;197(12):1787-91.
2003: Lisa J Drummond; Jodie McCoubrey; David G E Smith; John M Starr; Ian R Poxton
Changes in sensitivity patterns to selected antibiotics in Clostridium difficile in geriatric in-patients over an 18-month period.
Journal of medical microbiology 2003;52(Pt 3):259-63.
2002: Clett Erridge; Elliott Bennett-Guerrero; Ian R Poxton
Structure and function of lipopolysaccharides.
Microbes and infection / Institut Pasteur 2002;4(8):837-51.
2002: M Yücesoy; Jodie McCoubrey; R Brown; Ian R Poxton
Detection of toxin production in Clostridium difficile strains by three different methods.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2002;8(7):413-8.
2002: Lynsey A Garrett; Robert Brown; Ian R Poxton
A comparative study of the intestinal microbiota of healthy horses and those suffering from equine grass sickness.
Veterinary microbiology 2002;87(1):81-8.
2002: Jan Braun; C Caroline Blackwell; Ian R Poxton; Omar R El Ahmer; Ann E Gordon; Osama M Al Madani; Donald M Weir; Sonja Giersen; Josef Beuth
Proinflammatory responses to lipo-oligosaccharide of Neisseria meningitidis immunotype strains in relation to virulence and disease.
The Journal of infectious diseases 2002;185(10):1431-8.
2002: Clett Erridge; John Stewart; Elliott Bennett-Guerrero; Thomas J McIntosh; Ian R Poxton
The biological activity of a liposomal complete core lipopolysaccharide vaccine.
Journal of endotoxin research 2002;8(1):39-46.
2001: L C Hunter; Ian R Poxton
Systemic antibodies to Clostridium botulinum type C: do they protect horses from grass sickness (dysautonomia)?
Equine veterinary journal 2001;33(6):547-53.
2001: Ian R Poxton; Jodie McCoubrey; G Blair
The pathogenicity of Clostridium difficile.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2001;7(8):421-7.
2001: Jodie McCoubrey; Ian R Poxton
Variation in the surface layer proteins of Clostridium difficile.
FEMS immunology and medical microbiology 2001;31(2):131-5.
2001: CG Currie; K McCallum; Ian R Poxton
Mucosal and systemic antibody responses to the lipopolysaccharide of Escherichia coli O157 in health and disease.
Journal of medical microbiology 2001;50(4):345-54.
2001: M Łuczak; P Obuch-Woszczatyński; Hanna Pituch; P Leszczyński; Gayane Martirosian; S Patrick; Ian R Poxton; R G Wintermans; L Dubreuil; F Meisel-Mikołajczyk
Search for enterotoxin gene in Bacteroides fragilis strains isolated from clinical specimens in Poland, Great Britain, The Netherlands and France.
Medical science monitor : international medical journal of experimental and clinical research 2001;7(2):222-5.
2000: S S Hoque; Subrata Ghosh; Ian R Poxton
Differences in intestinal humoral immunity between healthy volunteers from UK and Bangladesh.
European journal of gastroenterology & hepatology 2000;12(11):1185-93.
2000: Elliott Bennett-Guerrero; Thomas J McIntosh; GR Barclay; D S Snyder; R J Gibbs; Monty Mythen; Ian R Poxton
Preparation and preclinical evaluation of a novel liposomal complete-core lipopolysaccharide vaccine.
Infection and immunity 2000;68(11):6202-8.
2000: Elliott Bennett-Guerrero; GR Barclay; M E Youssef; Sabera Hossain; Frances Vela-Cantos; LA Andres; Ian R Poxton
Exposure to bacteroides fragilis endotoxin during cardiac surgery.
Anesthesia and analgesia 2000;90(4):819-23.
2000: Michael Hutchison; E C Bonell; Ian R Poxton; John R W Govan
Endotoxic activity of lipopolysaccharides isolated from emergent potential cystic fibrosis pathogens.
FEMS immunology and medical microbiology 2000;27(1):73-7.
1999: L C Hunter; J K Miller; Ian R Poxton
The association of Clostridium botulinum type C with equine grass sickness: a toxicoinfection?
Equine veterinary journal 1999;31(6):492-9.
1999: E Evans; Ian R Poxton; John R W Govan
Lipopolysaccharide chemotypes of Burkholderia cepacia.
Journal of medical microbiology 1999;48(9):825-32.
1999: CG Currie; Ian R Poxton
The lipopolysaccharide core type of Escherichia coli O157:H7 and other non-O157 verotoxin-producing E. coli.
FEMS immunology and medical microbiology 1999;24(1):57-62.
1998: Marie-Helene Ruchaud-Sparagano; C A Ruivenkamp; PL Riches; Ian R Poxton; Ian Dransfield
Differential effects of bacterial lipopolysaccharides upon neutrophil function.
FEBS letters 1998;430(3):363-9.
1998: Michael Hutchison; Ian R Poxton; John R W Govan
Burkholderia cepacia produces a hemolysin that is capable of inducing apoptosis and degranulation of mammalian phagocytes.
Infection and immunity 1998;66(5):2033-9.
1997: R Brown; H G Lough; Ian R Poxton
Phenotypic characteristics and lipopolysaccharides of human and animal isolates of Fusobacterium necrophorum.
Journal of medical microbiology 1997;46(10):873-8.
1997: Ian R Poxton; R Brown; A Sawyerr; A Ferguson
The mucosal anaerobic gram-negative bacteria of the human colon.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1997;25 Suppl 2():S111-3.
1997: Abdulhamid M Alkout; C Caroline Blackwell; Donald M Weir; Ian R Poxton; Robert A Elton; W Luman; K Palmer
Isolation of a cell surface component of Helicobacter pylori that binds H type 2, Lewis(a), and Lewis(b) antigens.
Gastroenterology 1997;112(4):1179-87.
1997: Ian R Poxton; R Brown; A Sawyerr; A Ferguson
Mucosa-associated bacterial flora of the human colon.
Journal of medical microbiology 1997;46(1):85-91.
1995: Ian R Poxton; D M Edmond
Biological activity of Bacteroides lipopolysaccharide--reappraisal.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1995;20 Suppl 2():S149-53.
1995: D Shaw; Ian R Poxton; John R W Govan
Biological activity of Burkholderia (Pseudomonas) cepacia lipopolysaccharide.
FEMS immunology and medical microbiology 1995;11(2):99-106.
1995: E Allan; Ian R Poxton; G R Barclay
Anti-bacteroides lipopolysaccharide IgG levels in healthy adults and sepsis patients.
FEMS immunology and medical microbiology 1995;11(1):5-12.
1995: D M Delahooke; G R Barclay; Ian R Poxton
Tumor necrosis factor induction by an aqueous phenol-extracted lipopolysaccharide complex from Bacteroides species.
Infection and immunity 1995;63(3):840-6.
1995: D M Delahooke; G R Barclay; Ian R Poxton
A re-appraisal of the biological activity of bacteroides LPS.
Journal of medical microbiology 1995;42(2):102-12.
1994: E Allan; Ian R Poxton
The influence of growth medium on serum sensitivity of Bacteroides species.
Journal of medical microbiology 1994;41(1):45-50.
1994: AT Saadi; Donald M Weir; Ian R Poxton; J Stewart; SD Essery; C Caroline Blackwell; MW Raza; Anthony Busuttil
Isolation of an adhesin from Staphylococcus aureus that binds Lewis a blood group antigen and its relevance to sudden infant death syndrome.
FEMS immunology and medical microbiology 1994;8(4):315-20.
1994: S L Butler; J W Nelson; Ian R Poxton; John R W Govan
Serum sensitivity of Burkholderia (Pseudomonas) cepacia isolates from patients with cystic fibrosis.
FEMS immunology and medical microbiology 1994;8(4):285-92.
1993: D Nelson; T E Delahooke; Ian R Poxton
Influence of subinhibitory levels of antibiotics on expression of Escherichia coli lipopolysaccharide and binding of anti-lipopolysaccharide monoclonal antibodies.
Journal of medical microbiology 1993;39(2):100-6.
1993: D M Edmond; Ian R Poxton; F di Padova
The accessibility of cross-reactive anti-lipopolysaccharide-core monoclonal antibodies to Escherichia coli grown in sub-MICs of temocillin and other antibiotics.
The Journal of antimicrobial chemotherapy 1993;31(5):673-80.
1992: A P Gibb; G R Barclay; Ian R Poxton; F di Padova
Frequencies of lipopolysaccharide core types among clinical isolates of Escherichia coli defined with monoclonal antibodies.
The Journal of infectious diseases 1992;166(5):1051-7.
1992: J W Nelson; G R Barclay; L R Micklem; Ian R Poxton; John R W Govan
Production and characterisation of mouse monoclonal antibodies reactive with the lipopolysaccharide core of Pseudomonas aeruginosa.
Journal of medical microbiology 1992;36(5):358-65.
1990: J McCourtie; Ian R Poxton
Characterisation of Bacteroides from sheep periodontal disease by SDS-PAGE of outer membrane proteins.
FEMS microbiology letters 1990;59(1-2):5-9.
1990: J McCourtie; Ian R Poxton; R Brown; C R Whittaker; J A Spence; G U Aitchison
A longitudinal study of the cultivable subgingival anaerobic bacteria isolated from sheep during the development of broken mouth periodontitis.
Journal of medical microbiology 1990;31(4):275-83.
1989: J McCourtie; Ian R Poxton; J A Spence; G U Aitchison
Preliminary study of the anaerobic bacteria isolated from subgingival plaque from sheep.
Veterinary microbiology 1989;21(2):139-46.
1989: R Brown; K E Hornett; Ian R Poxton
Immunochemistry of the cell surfaces of Bacteroides bivius and Bacteroides disiens.
Journal of medical microbiology 1989;28(4):267-73.