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Shimoga Prakash

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Chuang Lu; Suresh K Balani; Mark G Qian; Shimoga R Prakash; Patricia S Ducray; Lisa L Von Moltke
Quantitative prediction and clinical observation of a CYP3A inhibitor-based drug-drug interactions with MLN3897, a potent C-C chemokine receptor-1 antagonist.
Chuang Lu; Cicely Berg; Shimoga R Prakash; Frank W Lee; Suresh K Balani
Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. III. In vitro-in vivo correlation with fluconazole.
Chuang Lu; Gerald T Miwa; Shimoga R Prakash; Liang-Shang Gan; Suresh K Balani
A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.

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All Publications

2010: Chuang Lu; Suresh K Balani; Mark G Qian; Shimoga R Prakash; Patricia S Ducray; Lisa L Von Moltke
Quantitative prediction and clinical observation of a CYP3A inhibitor-based drug-drug interactions with MLN3897, a potent C-C chemokine receptor-1 antagonist.
The Journal of pharmacology and experimental therapeutics 2010;332(2):562-8.
2008: Chuang Lu; Cicely Berg; Shimoga R Prakash; Frank W Lee; Suresh K Balani
Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. III. In vitro-in vivo correlation with fluconazole.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(7):1261-6.
2007: Chuang Lu; Gerald T Miwa; Shimoga R Prakash; Liang-Shang Gan; Suresh K Balani
A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(1):79-85.
2004: Xiao-Xin Yan; Tong Li; Cynthia M Rominger; Shimoga R Prakash; Philip C Wong; Richard E Olson; Robert Zaczek; Yu-Wen Li
Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(12):2942-52.
2003: Ge Zhang; Ning Huang; Yu-Wen Li; Xiaoping Qi; Anne P Marshall; Xiao-Xin Yan; Geraldine Hill; Cynthia M Rominger; Shimoga R Prakash; Rajagopal Bakthavatchalam; David H Rominger; Paul J Gilligan; Robert Zaczek
Pharmacological characterization of a novel nonpeptide antagonist radioligand, (+/-)-N-[2-methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for corticotropin-releasing factor1 receptors.
The Journal of pharmacology and experimental therapeutics 2003;305(1):57-69.
2002: Abdul E Mutlib; Shiang-Yuan Chen; Robert Espina; John P Shockcor; Shimoga R Prakash; Liang-Shang Gan
P450-mediated metabolism of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)- [1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole- 5-carboxamide (DPC 423) and its analogues to aldoximes. Characterization of glutathione conjugates of postulated intermediates derived from aldoximes.
Chemical research in toxicology 2002;15(1):63-75.
2002: Abdul E Mutlib; John P Shockcor; Shiang-Yuan Chen; Robert Espina; Donald J P Pinto; Michael J Orwat; Shimoga R Prakash; Liang-Shang Gan
Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metabolites by liquid chromatography/mass spectrometry and NMR.
Chemical research in toxicology 2002;15(1):48-62.
2001: Abdul E Mutlib; John P Shockcor; Shiang-Yuan Chen; Robert Espina; J Lin; N Graciani; Shimoga R Prakash; Liang-Shang Gan
Formation of unusual glutamate conjugates of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423) and its analogs: the role of gamma-glutamyltranspeptidase in the biotransformation of benzylamines.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(10):1296-306.
2000: Dietmar Seiffert; Jodi D Bradley; Cynthia M Rominger; David H Rominger; F Yang; Jere E Meredith; Qian Wang; Arthur H Roach; Lorin A Thompson; Susan M Spitz; Jeffrey N Higaki; Shimoga R Prakash; Andrew P Combs; Robert Copeland; Stephen P Arneric; Paul R Hartig; David W Robertson; Barbara Cordell; Andrew M Stern; Richard E Olson; Robert Zaczek
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors.
The Journal of biological chemistry 2000;275(44):34086-91.
2000: Abdul E Mutlib; Hao Chen; John P Shockcor; Robert Espina; S Chen; K Cao; A Du; GA Nemeth; Shimoga R Prakash; Liang-Shang Gan
Characterization of novel glutathione adducts of a non-nucleoside reverse transcriptase inhibitor, (S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3, 4-dihydro-2(1H)-quinazolinone (DPC 961), in rats. Possible formation of an oxirene metabolic intermediate from a disubstituted alkyne.
Chemical research in toxicology 2000;13(8):775-84.