FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Thazha Prakash

Research Profile

Chemicals & Drugs

Concepts & Ideas

Co-author Network

Publications

TOP 3
Masayuki Matsui; Thazha P Prakash; David R Corey
Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter.
Dongbo Yu; Don W Cleveland; Stanley T Crooke; Holly B Kordasiewicz; Walt F Lima; Jing Liu; Hannah Pendergraff; Thazha P Prakash; Eric E Swayze; David R Corey
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.
Walt F Lima; Heather M Murray; Susan F Murray; Thazha P Prakash; Punit P Seth; Eric E Swayze; Hans Gaus; Garth A Kinberger; Cheryl S Li; Wenyu Li; Alfred E Chappell; Stanley T Crooke
Single-stranded siRNAs activate RNAi in animals.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Thazha Prakash (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Masayuki Matsui; Thazha P Prakash; David R Corey
Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter.
ACS chemical biology 2013;8(1):122-6.
2012: Dongbo Yu; Don W Cleveland; Stanley T Crooke; Holly B Kordasiewicz; Walt F Lima; Jing Liu; Hannah Pendergraff; Thazha P Prakash; Eric E Swayze; David R Corey
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.
Cell 2012;150(5):895-908.
2012: Walt F Lima; Heather M Murray; Susan F Murray; Thazha P Prakash; Punit P Seth; Eric E Swayze; Hans Gaus; Garth A Kinberger; Cheryl S Li; Wenyu Li; Alfred E Chappell; Stanley T Crooke
Single-stranded siRNAs activate RNAi in animals.
Cell 2012;150(5):883-94.
2012: Pradeep S Pallan; Thazha P Prakash; Punit P Seth; Eric E Swayze; Charles R Allerson; Andres Berdeja; Martin Egli
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chemical communications (Cambridge, England) 2012;48(66):8195-7.
2012: Sue Murray; Michaela Norrbom; Thazha P Prakash; Andres Berdeja; Alfred Chappell; Damian Ittig; Erich Koller; Christian J Leumann; Eric E Swayze; Punit P Seth
TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry.
Nucleic acids research 2012;40(13):6135-43.
2012: Frank Rigo; Seung J Chun; Yimin Hua; Adrian R Krainer; Thazha P Prakash; C Frank Bennett
Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.
Nature chemical biology 2012;8(6):555-61.
2011: Martin Egli; Hans Gaus; Sam Lee; Pradeep S Pallan; Thazha P Prakash; Charles R Allerson; Andres Berdeja; Balkrishen Bhat; Eric E Swayze; Andrew Watt; Jinghua Yu; Punit P Seth
Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.
Journal of the American Chemical Society 2011;133(41):16642-9.
2011: Thazha P Prakash
An overview of sugar-modified oligonucleotides for antisense therapeutics.
Chemistry & biodiversity 2011;8(9):1616-41.
2011: Punit P Seth; Thazha P Prakash
Synthesis of 2',4'-bridged nucleosides using a new orthogonally protected sugar synthon: 5-O-(tert-butyldiphenylsilyl)-4-C-hydroxymethyl-1,2-O-isopropylidene-3-O-napthyl-α-D-allofuranose.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2011;Chapter 1():Unit 1.24.
2010: Punit P Seth; Charles R Allerson; Andres Berdeja; Andrew Siwkowski; Pradeep S Pallan; Hans Gaus; Thazha P Prakash; Andrew T Watt; Martin Egli; Eric E Swayze
An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.
Journal of the American Chemical Society 2010;132(42):14942-50.
2010: Punit P Seth; Guillermo Vasquez; Charles A Allerson; Andres Berdeja; Hans Gaus; Garth A Kinberger; Thazha P Prakash; Michael T Migawa; Balkrishen Bhat; Eric E Swayze
Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.
The Journal of organic chemistry 2010;75(5):1569-81.
2010: Thazha P Prakash; Andrew Siwkowski; Charles R Allerson; Michael T Migawa; Sam Lee; Hans Gaus; Chris Black; Punit P Seth; Eric E Swayze; Balkrishen Bhat
Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.
Journal of medicinal chemistry 2010;53(4):1636-50.
2009: Thazha P Prakash; Nishant Naik; Namir Sioufi; Balkrishen Bhat; Eric E Swayze
Activity of siRNAs with 2-thio-2'-O-methyluridine modification in mammalian cells.
Nucleosides, nucleotides & nucleic acids 2009;28(10):902-10.
2009: Pradeep S Pallan; Thazha P Prakash; Feng Li; Robert L Eoff; Muthiah Manoharan; Martin Egli
A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chemical communications (Cambridge, England) 2009;(15):2017-9.
2009: Walt F Lima; Heather Murray; Josh G Nichols; Hongjiang Wu; Hong Sun; Thazha P Prakash; Andres R Berdeja; Hans J Gaus; Stanley T Crooke
Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.
The Journal of biological chemistry 2009;284(4):2535-48.
2009: Punit P Seth; Andrew Siwkowski; Charles R Allerson; Guillermo Vasquez; Sam Lee; Thazha P Prakash; Edward V Wancewicz; Donna Witchell; Eric E Swayze
Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.
Journal of medicinal chemistry 2009;52(1):10-3.
2008: Thazha P Prakash; Andrew M Kawasaki; Edward V Wancewicz; Lijiang Shen; Brett P Monia; Bruce S Ross; Balkrishen Bhat; Muthiah Manoharan
Comparing in vitro and in vivo activity of 2'-O-[2-(methylamino)-2-oxoethyl]- and 2'-O-methoxyethyl-modified antisense oligonucleotides.
Journal of medicinal chemistry 2008;51(9):2766-76.
2008: Punit P Seth; Andrew Siwkowski; Charles R Allerson; Guillermo Vasquez; Sam Lee; Thazha P Prakash; Garth Kinberger; Michael T Migawa; Hans Gaus; Balkrishen Bhat; Eric E Swayze
Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.
Nucleic acids symposium series (2004) 2008;(52):553-4.
2007: Thazha P Prakash; Balkrishen Bhat
2'-Modified oligonucleotides for antisense therapeutics.
Current topics in medicinal chemistry 2007;7(7):641-9.
2007: Thazha P Prakash; Ask Püschl; Muthiah Manoharan
N,N'-Bis-(2-(cyano)ethoxycarbonyl)-2-methyl-2-thiopseudourea: a guanylating reagent for synthesis of 2'-O-[2-(Guanidinium)ethyl]-modified oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2007;26(2):149-59.
2006: Thazha P Prakash; Bryan A Kraynack; Brenda F Baker; Eric E Swayze; Balkrishen Bhat
RNA interference by 2',5'-linked nucleic acid duplexes in mammalian cells.
Bioorganic & medicinal chemistry letters 2006;16(12):3238-40.
2006: Feng Li; Sanjay Sarkhel; Christopher J Wilds; Zdzislaw Wawrzak; Thazha P Prakash; Muthiah Manoharan; Martin Egli
2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry 2006;45(13):4141-52.
2006: Prasad Dande; Thazha P Prakash; Namir Sioufi; Hans Gaus; Russell Jarres; Andreas Berdeja; Eric E Swayze; Richard H Griffey; Balkrishen Bhat
Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.
Journal of medicinal chemistry 2006;49(5):1624-34.
2006: Erich Koller; Stephanie Propp; Heather Murray; Walt F Lima; Balkrishen Bhat; Thazha P Prakash; Charles R Allerson; Eric E Swayze; Eric G Marcusson; Nicholas Dean
Competition for RISC binding predicts in vitro potency of siRNA.
Nucleic acids research 2006;34(16):4467-76.
2005: Thazha P Prakash; Charles R Allerson; Prasad Dande; Timothy A Vickers; Namir Sioufi; Russell Jarres; Brenda F Baker; Eric E Swayze; Richard H Griffey; Balkrishen Bhat
Positional effect of chemical modifications on short interference RNA activity in mammalian cells.
Journal of medicinal chemistry 2005;48(13):4247-53.
2005: Martin Egli; George Minasov; Valentina Tereshko; Pradeep S Pallan; Marianna Teplova; Gopal B Inamati; Elena A Lesnik; Steve R Owens; Bruce S Ross; Thazha P Prakash; Muthiah Manoharan
Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry 2005;44(25):9045-57.
2005: Joanne E Tomassini; Krista Getty; Mark Stahlhut; Sung Shim; Balkrishen Bhat; Anne B Eldrup; Thazha P Prakash; Steven S Carroll; Osvaldo A Flores; Malcolm MacCoss; Daniel R McMasters; Giovanni Migliaccio; David B Olsen
Inhibitory effect of 2'-substituted nucleosides on hepatitis C virus replication correlates with metabolic properties in replicon cells.
Antimicrobial agents and chemotherapy 2005;49(5):2050-8.
2005: Thazha P Prakash; Marija Prhavc; Anne B Eldrup; P Dan Cook; Steven S Carroll; David B Olsen; Mark Stahlhut; Joanne E Tomassini; Malcolm MacCoss; Sheila M Galloway; Cathy Hilliard; Balkrishen Bhat
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
Journal of medicinal chemistry 2005;48(4):1199-210.
2005: Charles R Allerson; Namir Sioufi; Russell Jarres; Thazha P Prakash; Nishant Naik; Andres Berdeja; Lisa Wanders; Richard H Griffey; Eric E Swayze; Balkrishen Bhat
Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.
Journal of medicinal chemistry 2005;48(4):901-4.
2005: Benjamin Diop-Frimpong; Thazha P Prakash; Kallanthottathil G Rajeev; Muthiah Manoharan; Martin Egli
Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.
Nucleic acids research 2005;33(16):5297-307.
2004: Rekha Pattanayek; Latsavongsakda Sethaphong; Chongle Pan; Marija Prhavc; Thazha P Prakash; Muthiah Manoharan; Martin Egli
Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.
Journal of the American Chemical Society 2004;126(46):15006-7.
2004: Anne B Eldrup; Marija Prhavc; Jennifer Brooks; Balkrishen Bhat; Thazha P Prakash; Quanlai Song; Sanjib Bera; Neelima Bhat; Prasad Dande; P Dan Cook; C Frank Bennett; Steven S Carroll; Richard G Ball; Michele Bosserman; Christine Burlein; Lawrence F Colwell; John F Fay; Osvaldo A Flores; Krista Getty; Robert L LaFemina; Joseph F Leone; Malcolm MacCoss; Daniel R McMasters; Joanne E Tomassini; Derek Von Langen; Bohdan Wolanski; David B Olsen
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
Journal of medicinal chemistry 2004;47(21):5284-97.
2004: Walt F Lima; Josh G Nichols; Hongjiang Wu; Thazha P Prakash; Michael T Migawa; Tadeusz K Wyrzykiewicz; Balkrishen Bhat; Stanley T Crooke
Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.
The Journal of biological chemistry 2004;279(35):36317-26.
2004: Thazha P Prakash; Ask Püschl; Elena A Lesnik; Venkatraman Mohan; Valentina Tereshko; Martin Egli; Muthiah Manoharan
2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures.
Organic letters 2004;6(12):1971-4.
2004: Anne B Eldrup; Charles R Allerson; C Frank Bennett; Sanjib Bera; Balkrishen Bhat; Neelima Bhat; Michele Bosserman; Jennifer Brooks; Christine Burlein; Steven S Carroll; P Dan Cook; Krista Getty; Malcolm MacCoss; Daniel R McMasters; David B Olsen; Thazha P Prakash; Marija Prhavc; Quanlai Song; Joanne E Tomassini; Jie Xia
Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.
Journal of medicinal chemistry 2004;47(9):2283-95.
2004: Thazha P Prakash; Joseph F Johnston; Mark J Graham; Thomas P Condon; Muthiah Manoharan
2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo.
Nucleic acids research 2004;32(2):828-33.
2003: Walt F Lima; Hongjiang Wu; Josh G Nichols; Thazha P Prakash; Vasulinga T Ravikumar; Stanley T Crooke
Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.
The Journal of biological chemistry 2003;278(50):49860-7.
2003: Kallanthottathil G Rajeev; Thazha P Prakash; Muthiah Manoharan
2'-modified-2-thiothymidine oligonucleotides.
Organic letters 2003;5(17):3005-8.
2003: Marija Prhavc; Thazha P Prakash; George Minasov; P Dan Cook; Martin Egli; Muthiah Manoharan
2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects.
Organic letters 2003;5(12):2017-20.
2003: Thazha P Prakash; Andrew M Kawasaki; Elena A Lesnik; Stephen R Owens; Muthiah Manoharan
2'-O-[2-(amino)-2-oxoethyl] oligonucleotides.
Organic letters 2003;5(4):403-6.
2002: Thazha P Prakash; Muthiah Manoharan; Andrew M Kawasaki; Allister S Fraser; Elena A Lesnik; Namir Sioufi; Janet M Leeds; Marianna Teplova; Martin Egli
2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.
Biochemistry 2002;41(39):11642-8.
2002: Thazha P Prakash; Andrew M Kawasaki; Allister S Fraser; Guillermo Vasquez; Muthiah Manoharan
Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides.
The Journal of organic chemistry 2002;67(2):357-69.
2001: Thazha P Prakash; A M Kawasaki; J F Johnston; Mark J Graham; Thomas P Condon; Muthiah Manoharan
Antisense properties of 2'-O-dimethylaminooxyethyl (2'-O-DMAOE) oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):829-32.
2001: Valentina Tereshko; Christopher J Wilds; George Minasov; Thazha P Prakash; Martin A Maier; A Howard; Zdzislaw Wawrzak; Muthiah Manoharan; Martin Egli
Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic acids research 2001;29(5):1208-15.
2000: Thazha P Prakash; Muthiah Manoharan; Andrew M Kawasaki; Elena A Lesnik; S R Owens; G Vasquez
2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.
Organic letters 2000;2(25):3995-8.
1999: H Salo; Pasi Virta; Harri Hakala; Thazha P Prakash; A M Kawasaki; M Manoharan; Harri Lönnberg
Aminooxy functionalized oligonucleotides: preparation, on-support derivatization, and postsynthetic attachment to polymer support.
Bioconjugate chemistry 1999;10(5):815-23.