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John Pratt

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Rolf Wagner; Daniel P Larson; David W A Beno; Todd D Bosse; John F Darbyshire; Yi Gao; Bradley D Gates; Wenping He; Rodger F Henry; Lisa E Hernandez; Douglas K Hutchinson; Wen W Jiang; Warren M Kati; Larry Klein; Gennadiy Koev; William Kohlbrenner; A Chris Krueger; Jinrong Liu; Yaya Liu; Michelle A Long; Clarence J Maring; Sherie Masse; Tim Middleton; Debra A Montgomery; John K Pratt; Patricia Stuart; Akhteruzzaman Molla; Dale J Kempf
Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.
Yaya Liu; Pamela L Donner; John K Pratt; Wen W Jiang; Teresa Ng; Vijaya Gracias; Steve Baumeister; Paul E Wiedeman; Linda Traphagen; Usha Warrior; Clarence J Maring; Warren M Kati; Stevan W Djuric; Akhteruzzaman Molla
Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase.
Pamela L Donner; Qinghua Xie; John K Pratt; Clarence J Maring; Warren M Kati; Wen Jiang; Yaya Liu; Gennadiy Koev; Sherie Masse; Debra Montgomery; Akhteruzzaman Molla; Dale J Kempf
Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.

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All Publications

2009: Rolf Wagner; Daniel P Larson; David W A Beno; Todd D Bosse; John F Darbyshire; Yi Gao; Bradley D Gates; Wenping He; Rodger F Henry; Lisa E Hernandez; Douglas K Hutchinson; Wen W Jiang; Warren M Kati; Larry Klein; Gennadiy Koev; William Kohlbrenner; A Chris Krueger; Jinrong Liu; Yaya Liu; Michelle A Long; Clarence J Maring; Sherie Masse; Tim Middleton; Debra A Montgomery; John K Pratt; Patricia Stuart; Akhteruzzaman Molla; Dale J Kempf
Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.
Journal of medicinal chemistry 2009;52(6):1659-69.
2008: Yaya Liu; Pamela L Donner; John K Pratt; Wen W Jiang; Teresa Ng; Vijaya Gracias; Steve Baumeister; Paul E Wiedeman; Linda Traphagen; Usha Warrior; Clarence J Maring; Warren M Kati; Stevan W Djuric; Akhteruzzaman Molla
Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase.
Bioorganic & medicinal chemistry letters 2008;18(11):3173-7.
2008: Pamela L Donner; Qinghua Xie; John K Pratt; Clarence J Maring; Warren M Kati; Wen Jiang; Yaya Liu; Gennadiy Koev; Sherie Masse; Debra Montgomery; Akhteruzzaman Molla; Dale J Kempf
Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.
Bioorganic & medicinal chemistry letters 2008;18(8):2735-8.
2006: Todd W Rockway; Rong Zhang; Dachun Liu; David A Betebenner; Keith F McDaniel; John K Pratt; David W A Beno; Debra Montgomery; Wen W Jiang; Sherie Masse; Warren M Kati; Tim Middleton; Akhteruzzaman Molla; Clarence J Maring; Dale J Kempf
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.
Bioorganic & medicinal chemistry letters 2006;16(14):3833-8.
2006: A Chris Krueger; Darold L Madigan; Wen W Jiang; Warren M Kati; Dachun Liu; Yaya Liu; Clarence J Maring; Sherie Masse; Keith F McDaniel; Tim Middleton; Hongmei Mo; Akhteruzzaman Molla; Debra Montgomery; John K Pratt; Todd W Rockway; Rong Zhang; Dale J Kempf
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.
Bioorganic & medicinal chemistry letters 2006;16(13):3367-70.
2005: Arthur A Hancock; Marilyn S Diehl; Thomas A Fey; Eugene N Bush; Ramin Faghih; Thomas R Miller; Kathleen M Krueger; John K Pratt; Marlon D Cowart; RW Dickinson; Robin Shapiro; Victoria Knourek-Segel; Brian A Droz; C A McDowell; G Krishna; Michael E Brune; Timothy A Esbenshade; Peer B Jacobson
Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54 Suppl 1():S27-9.
2005: John K Pratt; Pamela Donner; Keith F McDaniel; Clarence J Maring; Warren M Kati; Hongmei Mo; Tim Middleton; Yaya Liu; Teresa Ng; Qinghua Xie; Rong Zhang; Debra Montgomery; Akhteruzzaman Molla; Dale J Kempf; William Kohlbrenner
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.
Bioorganic & medicinal chemistry letters 2005;15(6):1577-82.
2004: Arthur A Hancock; Marilyn S Diehl; Ramin Faghih; Eugene N Bush; Kathleen M Krueger; Gopala Krishna; Thomas R Miller; Denise M Wilcox; Phong Nguyen; John K Pratt; Marlon D Cowart; Timothy A Esbenshade; Peer B Jacobson
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Basic & clinical pharmacology & toxicology 2004;95(3):144-52.
2004: Irini Akritopoulou-Zanze; Jyoti R Patel; Kresna Hartandi; Jehrod Brenneman; Martin Winn; John K Pratt; Marlena Grynfarb; Annika Goos-Nisson; Thomas W von Geldern; Philip R Kym
Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.
Bioorganic & medicinal chemistry letters 2004;14(9):2079-82.
2004: Steven W Elmore; John K Pratt; Michael J Coghlan; Yue Mao; Brian E Green; David D Anderson; Michael Stashko; Chun W Lin; Doug H Falls; Masaki Nakane; Loan Miller; Curtis Tyree; Jeffrey N Miner; Ben Lane
Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators.
Bioorganic & medicinal chemistry letters 2004;14(7):1721-7.
2004: Marlon D Cowart; Ramin Faghih; Gregory A Gfesser; Michael Curtis; John K Pratt; Youssef L Bennani; Gerard B Fox; Timothy A Esbenshade; Arthur A Hancock
The medicinal chemistry of novel H(3) antagonists.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S69-70.
2004: Marlon D Cowart; John K Pratt; Andrew O Stewart; Youssef L Bennani; Timothy A Esbenshade; Arthur A Hancock
A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.
Bioorganic & medicinal chemistry letters 2004;14(3):689-93.
2003: Guo Zhu Zheng; Yue Mao; Abel Lee; John K Pratt; John R Koenig; Richard J Perner; Marlon D Cowart; Gregory A Gfesser; Steve McGaraughty; Katharine L Chu; Chang Zhu; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Elizabeth A Kowaluk; Andrew O Stewart
Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.
Bioorganic & medicinal chemistry letters 2003;13(18):3041-4.
2003: Philip R Kym; Michael E Kort; Michael J Coghlan; Jimmie L Moore; Rui Tang; James D Ratajczyk; Daniel P Larson; Steven W Elmore; John K Pratt; Michael Stashko; H Douglas Falls; Chun W Lin; Masaki Nakane; Loan Miller; Curtis Tyree; Jeffrey N Miner; Peer B Jacobson; Denise M Wilcox; Phong Nguyen; Benjamin C Lane
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Journal of medicinal chemistry 2003;46(6):1016-30.
2001: Steven W Elmore; Michael J Coghlan; David D Anderson; John K Pratt; Brian E Green; AX Wang; Michael Stashko; Chun W Lin; Curtis Tyree; Jeffrey N Miner; Peer B Jacobson; Denise M Wilcox; Benjamin C Lane
Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Journal of medicinal chemistry 2001;44(25):4481-91.
2001: Guo Zhu Zheng; C Lee; John K Pratt; Richard J Perner; M Q Jiang; Arthur Gomtsyan; Mark A Matulenko; Yue Mao; John R Koenig; Ki H Kim; Steven W Muchmore; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Katharine L Chu; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Kennan Marsh; Elizabeth A Kowaluk; Shripad S Bhagwat; Andrew O Stewart
Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(16):2071-4.
2001: Michael D Meyer; Robert J Altenbach; Hao Bai; Fatima Basha; William A Carroll; James Kerwin; SA Lebold; E Lee; John K Pratt; Kevin B Sippy; Karin R Tietje; Michael D Wendt; Michael E Brune; Steven A Buckner; Arthur A Hancock; Irene Drizin
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.
Journal of medicinal chemistry 2001;44(12):1971-85.