Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

William Pratt

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Phenomena

Protein Binding

Anatomy

Concepts & Ideas

Molecular Weight

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
22
Galigniana, Mario
22
Sanchez, Edwin Ramon
20
Morishima, Yoshihiro
15
Murphy, Patrick
14
Stancato, LF
13
Housley, Paul
13
Czar, Michael
12
Dittmar, KD
11
Kanelakis, Kimon
10
Silverstein, AM
10
Harrell, Jennifer
9
Welsh, Michael
8
Osawa, Yoichi
7
Simons, Stoney
6
Jove, Richard

Sign-in to see all Coauthors

Publications

TOP 3
Peng Hwei-Ming; Morishima Yoshihiro; Clapp Kelly M; Lau Miranda; Pratt William B; Osawa Yoichi
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.
Pratt William B; Morishima Yoshihiro; Osawa Yoichi
The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts.
Thomas Monzy; Harrell Jennifer M; Morishima Yoshihiro; Peng Hwei-Ming; Pratt William B; Lieberman Andrew P
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of William Pratt (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Peng Hwei-Ming; Morishima Yoshihiro; Clapp Kelly M; Lau Miranda; Pratt William B; Osawa Yoichi
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.
Biochemistry 2009;48(35):8483-90.
2008: Pratt William B; Morishima Yoshihiro; Osawa Yoichi
The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts.
The Journal of biological chemistry 2008;283(34):22885-9.
2006: Thomas Monzy; Harrell Jennifer M; Morishima Yoshihiro; Peng Hwei-Ming; Pratt William B; Lieberman Andrew P
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction.
Human molecular genetics 2006;15(11):1876-83.
2006: Pratt W B; Morishima Y; Murphy M; Harrell M
Chaperoning of glucocorticoid receptors.
Handbook of experimental pharmacology 2006;(172):111-38.
2005: Morishima Yoshihiro; Peng Hwei-Ming; Lin Hsia-lien; Hollenberg Paul F; Sunahara Roger K; Osawa Yoichi; Pratt William B
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation.
Biochemistry 2005;44(49):16333-40.
2005: Murphy Patrick J M; Morishima Yoshihiro; Kovacs Jeffrey J; Yao Tso-Pang; Pratt William B
Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone.
The Journal of biological chemistry 2005;280(40):33792-9.
2005: Kovacs Jeffrey J; Murphy Patrick J M; Gaillard Stéphanie; Zhao Xuan; Wu June-Tai; Nicchitta Christopher V; Yoshida Minoru; Toft David O; Pratt William B; Yao Tso-Pang
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.
Molecular cell 2005;18(5):601-7.
2004: Galigniana Mario D; Morishima Yoshihiro; Gallay Philippe A; Pratt William B
Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex.
The Journal of biological chemistry 2004;279(53):55754-9.
2004: Harrell Jennifer M; Murphy Patrick J M; Morishima Yoshihiro; Chen Haifeng; Mansfield John F; Galigniana Mario D; Pratt William B
Evidence for glucocorticoid receptor transport on microtubules by dynein.
The Journal of biological chemistry 2004;279(52):54647-54.
2004: Peng Hwei-Ming; Morishima Yoshihiro; Jenkins Gary J; Dunbar Anwar Y; Lau Miranda; Patterson Cam; Pratt William B; Osawa Yoichi
Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
The Journal of biological chemistry 2004;279(51):52970-7.
2004: Pratt William B; Galigniana Mario D; Harrell Jennifer M; DeFranco Donald B
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement.
Cellular signalling 2004;16(8):857-72.
2004: Billecke Scott S; Draganov Dragomir I; Morishima Yoshihiro; Murphy Patrick J M; Dunbar Anwar Y; Pratt William B; Osawa Yoichi
The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.
The Journal of biological chemistry 2004;279(29):30252-8.
2004: Murphy Patrick J M; Galigniana Mario D; Morishima Yoshihiro; Harrell Jennifer M; Kwok Roland P S; Ljungman Mats; Pratt William B
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.
The Journal of biological chemistry 2004;279(29):30195-201.
2004: Gerges Nashaat Z; Tran Irwin C; Backos Donald S; Harrell Jennifer M; Chinkers Michael; Pratt William B; Esteban José A
Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(20):4758-66.
2004: Galigniana Mario D; Harrell Jennifer M; O'Hagen Heather M; Ljungman Mats; Pratt William B
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
The Journal of biological chemistry 2004;279(21):22483-9.
2004: Galigniana Mario D; Harrell Jennifer M; Housley Paul R; Patterson Cam; Fisher Stephen K; Pratt William B
Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation.
Brain research. Molecular brain research 2004;123(1-2):27-36.
2004: Thomas Monzy; Dadgar Nahid; Aphale Abhishek; Harrell Jennifer M; Kunkel Robin; Pratt William B; Lieberman Andrew P
Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts.
The Journal of biological chemistry 2004;279(9):8389-95.
2004: Pratt William B; Galigniana Mario D; Morishima Yoshihiro; Murphy Patrick J M
Role of molecular chaperones in steroid receptor action.
Essays in biochemistry 2004;40():41-58.
2003: Morishima Yoshihiro; Kanelakis Kimon C; Murphy Patrick J M; Lowe Ezra R; Jenkins Gary J; Osawa Yoichi; Sunahara Roger K; Pratt William B
The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex.
The Journal of biological chemistry 2003;278(49):48754-63.
2003: Murphy Patrick J M; Morishima Yoshihiro; Chen Haifeng; Galigniana Mario D; Mansfield John F; Simons S Stoney; Pratt William B
Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft.
The Journal of biological chemistry 2003;278(37):34764-73.
2003: Pratt William B; Toft David O
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.
Experimental biology and medicine (Maywood, N.J.) 2003;228(2):111-33.
2003: Kanelakis Kimon C; Pratt William B
Regulation of glucocorticoid receptor ligand-binding activity by the hsp90/hsp70-based chaperone machinery.
Methods in enzymology 2003;364():159-73.
2002: Galigniana Mario D; Harrell Jennifer M; Murphy Patrick J M; Chinkers Michael; Radanyi Christine; Renoir Jack-Michel; Zhang Mingjie; Pratt William B
Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain.
Biochemistry 2002;41(46):13602-10.
2002: Kaul Sunil; Murphy Patrick J M; Chen Jun; Brown Lloyd; Pratt William B; Simons S Stoney
Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain.
The Journal of biological chemistry 2002;277(39):36223-32.
2002: Kanelakis Kimon C; Shewach Donna S; Pratt William B
Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly.
The Journal of biological chemistry 2002;277(37):33698-703.
2002: Billecke Scott S; Bender Andrew T; Kanelakis Kimon C; Murphy Patrick J M; Lowe Ezra R; Kamada Yasuhiko; Pratt William B; Osawa Yoichi
hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.
The Journal of biological chemistry 2002;277(23):20504-9.
2002: Harrell Jennifer M; Kurek Isaac; Breiman Adina; Radanyi Christine; Renoir Jack-Michel; Pratt William B; Galigniana Mario D
All of the protein interactions that link steroid receptor.hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells.
Biochemistry 2002;41(17):5581-7.
2001: Guo Y; Guettouche T; Fenna M; Boellmann F; Pratt W B; Toft D O; Smith D F; Voellmy R
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.
The Journal of biological chemistry 2001;276(49):45791-9.
2001: Houshyar H; Galigniana M D; Pratt W B; Woods J H
Differential responsivity of the hypothalamic-pituitary-adrenal axis to glucocorticoid negative-feedback and corticotropin releasing hormone in rats undergoing morphine withdrawal: possible mechanisms involved in facilitated and attenuated stress responses.
Journal of neuroendocrinology 2001;13(10):875-86.
2001: Murphy P J; Kanelakis K C; Galigniana M D; Morishima Y; Pratt W B
Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate.
The Journal of biological chemistry 2001;276(32):30092-8.
2001: Galigniana M D; Radanyi C; Renoir J M; Housley P R; Pratt W B
Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus.
The Journal of biological chemistry 2001;276(18):14884-9.
2001: Pratt W B; Krishna P; Olsen L J
Hsp90-binding immunophilins in plants: the protein movers.
Trends in plant science 2001;6(2):54-8.
2001: Morishima Y; Kanelakis K C; Murphy P J; Shewach D S; Pratt W B
Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes.
Biochemistry 2001;40(4):1109-16.
2000: Kanelakis K C; Murphy P J; Galigniana M D; Morishima Y; Takayama S; Reed J C; Toft D O; Pratt W B
hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1.
Biochemistry 2000;39(46):14314-21.
2000: Morishima Y; Murphy P J; Li D P; Sanchez E R; Pratt W B
Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket.
The Journal of biological chemistry 2000;275(24):18054-60.
2000: Morishima Y; Kanelakis K C; Silverstein A M; Dittmar K D; Estrada L; Pratt W B
The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system.
The Journal of biological chemistry 2000;275(10):6894-900.
1999: Pratt W B; Silverstein A M; Galigniana M D
A model for the cytoplasmic trafficking of signalling proteins involving the hsp90-binding immunophilins and p50cdc37.
Cellular signalling 1999;11(12):839-51.
1999: Silverstein A M; Galigniana M D; Kanelakis K C; Radanyi C; Renoir J M; Pratt W B
Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein.
The Journal of biological chemistry 1999;274(52):36980-6.
1999: Giannoukos G; Silverstein A M; Pratt W B; Simons S S
The seven amino acids (547-553) of rat glucocorticoid receptor required for steroid and hsp90 binding contain a functionally independent LXXLL motif that is critical for steroid binding.
The Journal of biological chemistry 1999;274(51):36527-36.
1999: Kanelakis K C; Morishima Y; Dittmar K D; Galigniana M D; Takayama S; Reed J C; Pratt W B
Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery.
The Journal of biological chemistry 1999;274(48):34134-40.
1999: Galigniana M D; Housley P R; DeFranco D B; Pratt W B
Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton.
The Journal of biological chemistry 1999;274(23):16222-7.
1999: Bender A T; Silverstein A M; Demady D R; Kanelakis K C; Noguchi S; Pratt W B; Osawa Y
Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo.
The Journal of biological chemistry 1999;274(3):1472-8.
1998: Galigniana M D; Scruggs J L; Herrington J; Welsh M J; Carter-Su C; Housley P R; Pratt W B
Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton.
Molecular endocrinology (Baltimore, Md.) 1998;12(12):1903-13.
1998: Pratt W B; Dittmar K D
Studies with Purified Chaperones Advance the Understanding of the Mechanism of Glucocorticoid Receptor-hsp90 Heterocomplex Assembly.
Trends in endocrinology and metabolism: TEM 1998;9(6):244-52.
1998: Caamaño C A; Morano M I; Dalman F C; Pratt W B; Akil H
A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling.
The Journal of biological chemistry 1998;273(32):20473-80.
1998: Silverstein A M; Grammatikakis N; Cochran B H; Chinkers M; Pratt W B
p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site.
The Journal of biological chemistry 1998;273(32):20090-5.
1998: Xu M; Dittmar K D; Giannoukos G; Pratt W B; Simons S S
Binding of hsp90 to the glucocorticoid receptor requires a specific 7-amino acid sequence at the amino terminus of the hormone-binding domain.
The Journal of biological chemistry 1998;273(22):13918-24.
1998: Pratt W B
The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1998;217(4):420-34.
1998: Dittmar K D; Banach M; Galigniana M D; Pratt W B
The role of DnaJ-like proteins in glucocorticoid receptor.hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex.
The Journal of biological chemistry 1998;273(13):7358-66.
1997: Dittmar K D; Demady D R; Stancato L F; Krishna P; Pratt W B
Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70.
The Journal of biological chemistry 1997;272(34):21213-20.
1997: Czar M J; Galigniana M D; Silverstein A M; Pratt W B
Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus.
Biochemistry 1997;36(25):7776-85.
1997: Silverstein A M; Galigniana M D; Chen M S; Owens-Grillo J K; Chinkers M; Pratt W B
Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.
The Journal of biological chemistry 1997;272(26):16224-30.
1997: Pratt W B; Toft D O
Steroid receptor interactions with heat shock protein and immunophilin chaperones.
Endocrine reviews 1997;18(3):306-60.
1997: Dittmar K D; Pratt W B
Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation.
The Journal of biological chemistry 1997;272(20):13047-54.
1997: Stancato L F; Silverstein A M; Owens-Grillo J K; Chow Y H; Jove R; Pratt W B
The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase.
The Journal of biological chemistry 1997;272(7):4013-20.
1997: Pratt W B
The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase.
Annual review of pharmacology and toxicology 1997;37():297-326.
1996: Owens-Grillo J K; Stancato L F; Hoffmann K; Pratt W B; Krishna P
Binding of immunophilins to the 90 kDa heat shock protein (hsp90) via a tetratricopeptide repeat domain is a conserved protein interaction in plants.
Biochemistry 1996;35(48):15249-55.
1996: Chen M S; Silverstein A M; Pratt W B; Chinkers M
The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant.
The Journal of biological chemistry 1996;271(50):32315-20.
1996: Czar M J; Welsh M J; Pratt W B
Immunofluorescence localization of the 90-kDa heat-shock protein to cytoskeleton.
European journal of cell biology 1996;70(4):322-30.
1996: Gralinski M R; Black S C; Stancato L F; Kilgore K S; Campau P A; Park J L; Ozeck M J; Pratt W B; Lucchesi B R
Heat stress protects the perfused rabbit heart from complement-mediated injury.
The American journal of physiology 1996;271(2 Pt 2):H571-8.
1996: Hutchison K A; Dittmar K D; Stancato L F; Pratt W B
Ability of various members of the hsp70 family of chaperones to promote assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90.
The Journal of steroid biochemistry and molecular biology 1996;58(3):251-8.
1996: Owens-Grillo J K; Czar M J; Hutchison K A; Hoffmann K; Perdew G H; Pratt W B
A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains.
The Journal of biological chemistry 1996;271(23):13468-75.
1996: Dittmar K D; Hutchison K A; Owens-Grillo J K; Pratt W B
Reconstitution of the steroid receptor.hsp90 heterocomplex assembly system of rabbit reticulocyte lysate.
The Journal of biological chemistry 1996;271(22):12833-9.
1996: Stancato L F; Silverstein A M; Gitler C; Groner B; Pratt W B
Use of the thiol-specific derivatizing agent N-iodoacetyl-3-[125I]iodotyrosine to demonstrate conformational differences between the unbound and hsp90-bound glucocorticoid receptor hormone binding domain.
The Journal of biological chemistry 1996;271(15):8831-6.
1996: Stancato L F; David M; Carter-Su C; Larner A C; Pratt W B
Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation.
The Journal of biological chemistry 1996;271(8):4134-7.
1996: Stancato L F; Hutchison K A; Krishna P; Pratt W B
Animal and plant cell lysates share a conserved chaperone system that assembles the glucocorticoid receptor into a functional heterocomplex with hsp90.
Biochemistry 1996;35(2):554-61.
1996: Pratt W B; Gehring U; Toft D O
Molecular chaperoning of steroid hormone receptors.
EXS 1996;77():79-95.
1995: Czar M J; Lyons R H; Welsh M J; Renoir J M; Pratt W B
Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus.
Molecular endocrinology (Baltimore, Md.) 1995;9(11):1549-60.
1995: Owens-Grillo J K; Hoffmann K; Hutchison K A; Yem A W; Deibel M R; Handschumacher R E; Pratt W B
The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor.
The Journal of biological chemistry 1995;270(35):20479-84.
1995: Hutchison K A; Stancato L F; Owens-Grillo J K; Johnson J L; Krishna P; Toft D O; Pratt W B
The 23-kDa acidic protein in reticulocyte lysate is the weakly bound component of the hsp foldosome that is required for assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90.
The Journal of biological chemistry 1995;270(32):18841-7.
1995: Caamaño C A; Morano M I; Dalman F C; Hoversten M T; Watson S J; Pratt W B; Akil H
Point mutations in the 90-kDa heat shock protein binding region of the glucocorticoid receptor affect the functional characteristics of the receptor.
Annals of the New York Academy of Sciences 1995;761():403-4.
1994: Czar M J; Owens-Grillo J K; Yem A W; Leach K L; Deibel M R; Welsh M J; Pratt W B
The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor.
Molecular endocrinology (Baltimore, Md.) 1994;8(12):1731-41.
1994: Hutchison K A; Dittmar K D; Pratt W B
All of the factors required for assembly of the glucocorticoid receptor into a functional heterocomplex with heat shock protein 90 are preassociated in a self-sufficient protein folding structure, a "foldosome".
The Journal of biological chemistry 1994;269(45):27894-9.
1994: Caamaño C A; Morano M I; Watson S J; Dalman F C; Pratt W B; Akil H
The functional relevance of the heteromeric structure of corticosteroid receptors.
Annals of the New York Academy of Sciences 1994;746():68-77; discussion 77-8, 131-3.
1994: Stancato L F; Chow Y H; Owens-Grillo J K; Yem A W; Deibel M R; Jove R; Pratt W B
The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class.
The Journal of biological chemistry 1994;269(35):22157-61.
1994: Czar M J; Owens-Grillo J K; Dittmar K D; Hutchison K A; Zacharek A M; Leach K L; Deibel M R; Pratt W B
Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex.
The Journal of biological chemistry 1994;269(15):11155-61.
1994: Pratt W B; Welsh M J
Chaperone functions of the heat shock proteins associated with steroid receptors.
Seminars in cell biology 1994;5(2):83-93.
1994: Hutchison K A; Dittmar K D; Czar M J; Pratt W B
Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90.
The Journal of biological chemistry 1994;269(7):5043-9.
1993: Hutchison K A; Dalman F C; Hoeck W; Groner B; Pratt W B
Localization of the approximately 12 kDa M(r) discrepancy in gel migration of the mouse glucocorticoid receptor to the major phosphorylated cyanogen bromide fragment in the transactivating domain.
The Journal of steroid biochemistry and molecular biology 1993;46(6):681-6.
1993: Stancato L F; Chow Y H; Hutchison K A; Perdew G H; Jove R; Pratt W B
Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.
The Journal of biological chemistry 1993;268(29):21711-6.
1993: Pratt W B
The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.
The Journal of biological chemistry 1993;268(29):21455-8.
1993: Pratt W B; Czar M J; Stancato L F; Owens J K
The hsp56 immunophilin component of steroid receptor heterocomplexes: could this be the elusive nuclear localization signal-binding protein?
The Journal of steroid biochemistry and molecular biology 1993;46(3):269-79.
1993: Hutchison K A; Scherrer L C; Czar M J; Stancato L F; Chow Y H; Jove R; Pratt W B
Regulation of glucocorticoid receptor function through assembly of a receptor-heat shock protein complex.
Annals of the New York Academy of Sciences 1993;684():35-48.
1993: Scherrer L C; Picard D; Massa E; Harmon J M; Simons S S; Yamamoto K R; Pratt W B
Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90.
Biochemistry 1993;32(20):5381-6.
1993: Stancato L F; Hutchison K A; Chakraborti P K; Simons S S; Pratt W B
Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor.
Biochemistry 1993;32(14):3729-36.
1993: Hutchison K A; Scherrer L C; Czar M J; Ning Y; Sanchez E R; Leach K L; Deibel M R; Pratt W B
FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function.
Biochemistry 1993;32(15):3953-7.
1992: Pratt W B
Control of steroid receptor function and cytoplasmic-nuclear transport by heat shock proteins.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(12):841-8.
1992: Scherrer L C; Pratt W B
Energy-dependent conversion of transformed cytosolic glucocorticoid receptors from soluble to particulate-bound form.
Biochemistry 1992;31(44):10879-86.
1992: Scherrer L C; Hutchison K A; Sanchez E R; Randall S K; Pratt W B
A heat shock protein complex isolated from rabbit reticulocyte lysate can reconstitute a functional glucocorticoid receptor-Hsp90 complex.
Biochemistry 1992;31(32):7325-9.
1992: Hutchison K A; Czar M J; Scherrer L C; Pratt W B
Monovalent cation selectivity for ATP-dependent association of the glucocorticoid receptor with hsp70 and hsp90.
The Journal of biological chemistry 1992;267(20):14047-53.
1992: Hutchison K A; Stancato L F; Jove R; Pratt W B
The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal.
The Journal of biological chemistry 1992;267(20):13952-7.
1992: Scherrer L C; Pratt W B
Association of the transformed glucocorticoid receptor with a cytoskeletal protein complex.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):719-21.
1992: Hutchison K A; Matic G; Czar M J; Pratt W B
DNA-binding and non-DNA-binding forms of the transformed glucocorticoid receptor.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):715-8.
1992: Pratt W B; Scherrer L C; Hutchison K A; Dalman F C
A model of glucocorticoid receptor unfolding and stabilization by a heat shock protein complex.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):223-9.
1992: Hutchison K A; Czar M J; Pratt W B
Evidence that the hormone-binding domain of the mouse glucocorticoid receptor directly represses DNA binding activity in a major portion of receptors that are "misfolded" after removal of hsp90.
The Journal of biological chemistry 1992;267(5):3190-5.
1992: Hutchison K A; Brott B K; De Leon J H; Perdew G H; Jove R; Pratt W B
Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system.
The Journal of biological chemistry 1992;267(5):2902-8.
1991: Meshinchi S; Stancato L F; Gordon B M; Jones K W; Pratt W B
Purification of the endogenous glucocorticoid receptor stabilizing factor.
Biochemistry 1991;30(35):8617-22.
1991: Hutchison K A; Matic G; Meshinchi S; Bresnick E H; Pratt W B
Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor.
The Journal of biological chemistry 1991;266(16):10505-9.
1991: Dalman F C; Sturzenbecker L J; Levin A A; Lucas D A; Perdew G H; Petkovitch M; Chambon P; Grippo J F; Pratt W B
Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90.
Biochemistry 1991;30(22):5605-8.
1991: Martins V R; Pratt W B; Terracio L; Hirst M A; Ringold G M; Housley P R
Demonstration by confocal microscopy that unliganded overexpressed glucocorticoid receptors are distributed in a nonrandom manner throughout all planes of the nucleus.
Molecular endocrinology (Baltimore, Md.) 1991;5(2):217-25.
1991: Dalman F C; Scherrer L C; Taylor L P; Akil H; Pratt W B
Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition.
The Journal of biological chemistry 1991;266(6):3482-90.
1990: Pratt W B; Dalman F C; Meshinchi S; Scherrer L C
The relationship between glucocorticoid receptor binding to Hsp90 and receptor function.
Nippon Naibunpi Gakkai zasshi 1990;66(12):1185-97.
1990: Scherrer L C; Dalman F C; Massa E; Meshinchi S; Pratt W B
Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex.
The Journal of biological chemistry 1990;265(35):21397-400.
1990: Sanchez E R; Hirst M; Scherrer L C; Tang H Y; Welsh M J; Harmon J M; Simons S S; Ringold G M; Pratt W B
Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90.
The Journal of biological chemistry 1990;265(33):20123-30.
1990: Housley P R; Sanchez E R; Danielsen M; Ringold G M; Pratt W B
Evidence that the conserved region in the steroid binding domain of the glucocorticoid receptor is required for both optimal binding of hsp90 and protection from proteolytic cleavage. A two-site model for hsp90 binding to the steroid binding domain.
The Journal of biological chemistry 1990;265(22):12778-81.
1990: Meshinchi S; Matic G; Hutchison K A; Pratt W B
Selective molybdate-directed covalent modification of sulfhydryl groups in the steroid-binding versus the DNA-binding domain of the glucocorticoid receptor.
The Journal of biological chemistry 1990;265(20):11643-9.
1990: Sanchez E R; Faber L E; Henzel W J; Pratt W B
The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins.
Biochemistry 1990;29(21):5145-52.
1990: Meshinchi S; Sanchez E R; Martell K J; Pratt W B
Elimination and reconstitution of the requirement for hormone in promoting temperature-dependent transformation of cytosolic glucocorticoid receptors to the DNA-binding state.
The Journal of biological chemistry 1990;265(9):4863-70.
1990: Dalman F C; Koenig R J; Perdew G H; Massa E; Pratt W B
In contrast to the glucocorticoid receptor, the thyroid hormone receptor is translated in the DNA binding state and is not associated with hsp90.
The Journal of biological chemistry 1990;265(7):3615-8.
1990: Bresnick E H; Dalman F C; Pratt W B
Direct stoichiometric evidence that the untransformed Mr 300,000, 9S, glucocorticoid receptor is a core unit derived from a larger heteromeric complex.
Biochemistry 1990;29(2):520-7.
1989: Dalman F C; Bresnick E H; Patel P D; Perdew G H; Watson S J; Pratt W B
Direct evidence that the glucocorticoid receptor binds to hsp90 at or near the termination of receptor translation in vitro.
The Journal of biological chemistry 1989;264(33):19815-21.
1989: Redmond T; Sanchez E R; Bresnick E H; Schlesinger M J; Toft D O; Pratt W B; Welsh M J
Immunofluorescence colocalization of the 90-kDa heat-shock protein and microtubules in interphase and mitotic mammalian cells.
European journal of cell biology 1989;50(1):66-75.
1989: Pratt W B; Sanchez E R; Bresnick E H; Meshinchi S; Scherrer L C; Dalman F C; Welsh M J
Interaction of the glucocorticoid receptor with the Mr 90,000 heat shock protein: an evolving model of ligand-mediated receptor transformation and translocation.
Cancer research 1989;49(8 Suppl):2222s-2229s.
1989: Bresnick E H; Dalman F C; Sanchez E R; Pratt W B
Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor.
The Journal of biological chemistry 1989;264(9):4992-7.
1989: Meshinchi S; Pratt W B
Evidence that removal of an endogenous metal that stabilizes the untransformed glucocorticoid receptor in cytosol allows ligand-independent receptor transformation.
Journal of steroid biochemistry 1989;34(1-6):315-7.
1988: Meshinchi S; Grippo J F; Sanchez E R; Bresnick E H; Pratt W B
Evidence that the endogenous heat-stable glucocorticoid receptor stabilizing factor is a metal component of the untransformed receptor complex.
The Journal of biological chemistry 1988;263(32):16809-17.
1988: Dalman F C; Sanchez E R; Lin A L; Perini F; Pratt W B
Localization of phosphorylation sites with respect to the functional domains of the mouse L cell glucocorticoid receptor.
The Journal of biological chemistry 1988;263(25):12259-67.
1988: Sanchez E R; Redmond T; Scherrer L C; Bresnick E H; Welsh M J; Pratt W B
Evidence that the 90-kilodalton heat shock protein is associated with tubulin-containing complexes in L cell cytosol and in intact PtK cells.
Molecular endocrinology (Baltimore, Md.) 1988;2(8):756-60.
1988: Bresnick E H; Sanchez E R; Harrison R W; Pratt W B
Hydrogen peroxide stabilizes the steroid-binding state of rat liver glucocorticoid receptors by promoting disulfide bond formation.
Biochemistry 1988;27(8):2866-72.
1988: Bresnick E H; Sanchez E R; Pratt W B
Relationship between glucocorticoid receptor steroid-binding capacity and association of the Mr 90,000 heat shock protein with the unliganded receptor.
Journal of steroid biochemistry 1988;30(1-6):267-9.
1987: Tienrungroj W; Sanchez E R; Housley P R; Harrison R W; Pratt W B
Glucocorticoid receptor phosphorylation, transformation, and DNA binding.
The Journal of biological chemistry 1987;262(36):17342-9.
1987: Sanchez E R; Meshinchi S; Schlesinger M J; Pratt W B
Demonstration that the 90-kilodalton heat shock protein is bound to the glucocorticoid receptor in its 9S nondeoxynucleic acid binding form.
Molecular endocrinology (Baltimore, Md.) 1987;1(12):908-12.
1987: Tienrungroj W; Pratt S E; Grippo J F; Holmgren A; Pratt W B
The heat-stable cytosolic factor that promotes glucocorticoid receptor binding to DNA is neither thioredoxin nor ribonuclease.
Journal of steroid biochemistry 1987;28(5):449-57.
1987: Tienrungroj W; Meshinchi S; Sanchez E R; Pratt S E; Grippo J F; Holmgren A; Pratt W B
The role of sulfhydryl groups in permitting transformation and DNA binding of the glucocorticoid receptor.
The Journal of biological chemistry 1987;262(15):6992-7000.
1987: Sanchez E R; Meshinchi S; Tienrungroj W; Schlesinger M J; Toft D O; Pratt W B
Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.
The Journal of biological chemistry 1987;262(15):6986-91.
1986: Sanchez E R; Housley P R; Pratt W B
The molybdate-stabilized glucocorticoid binding complex of L-cells contains a 98-100 kdalton steroid binding phosphoprotein and a 90 kdalton nonsteroid-binding phosphoprotein that is part of the murine heat-shock complex.
Journal of steroid biochemistry 1986;24(1):9-18.
1985: Housley P R; Sanchez E R; Westphal H M; Beato M; Pratt W B
The molybdate-stabilized L-cell glucocorticoid receptor isolated by affinity chromatography or with a monoclonal antibody is associated with a 90-92-kDa nonsteroid-binding phosphoprotein.
The Journal of biological chemistry 1985;260(25):13810-7.
1985: Sanchez E R; Toft D O; Schlesinger M J; Pratt W B
Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.
The Journal of biological chemistry 1985;260(23):12398-401.
1985: Dahmer M K; Tienrungroj W; Pratt W B
Purification and preliminary characterization of a macromolecular inhibitor of glucocorticoid receptor binding to DNA.
The Journal of biological chemistry 1985;260(12):7705-15.
1984: Dahmer M K; Housley P R; Pratt W B
Effects of molybdate and endogenous inhibitors on steroid-receptor inactivation, transformation, and translocation.
Annual review of physiology 1984;46():67-81.
1983: Grippo J F; Tienrungroj W; Dahmer M K; Housley P R; Pratt W B
Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.
The Journal of biological chemistry 1983;258(22):13658-64.
1983: Leach K L; Dahmer M K; Pratt W B
Glucocorticoid receptor stabilization: relative effects of molybdate ion on inactivation by alkaline phosphatase and phospholipase A2.
Journal of steroid biochemistry 1983;18(1):105-7.
1982: Housley P R; Dahmer M K; Pratt W B
Inactivation of glucocorticoid-binding capacity by protein phosphatases in the presence of molybdate and complete reactivation of dithiothreitol.
The Journal of biological chemistry 1982;257(15):8615-8.
1982: Leach K L; Grippo J F; Housley P R; Dahmer M K; Salive M E; Pratt W B
Characteristics of an endogenous glucocorticoid receptor stabilizing factor.
The Journal of biological chemistry 1982;257(1):381-8.

Sign-in to see more