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Jochen Prehn

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Monika A Jarzabek; Emmet McCormack; Jochen H M Prehn; Kai-Ove Skaftnesmo; Rolf Bjerkvig; Patrick Dicker; Peter C Huszthy; Annette T Byrne
In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme.
Ujval Anilkumar; Caoimhín G Concannon; Heiko Düssmann; Hans-Georg König; Petronela Weisová; Jochen H M Prehn
AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.
Tobias Engel; Michael A Farrell; Caoimhin G Concannon; Norman Delanty; Eva M Jimenez-Mateos; Alba Jimenez-Pacheco; Jose J Lucas; Guillaume Mesuret; Catherine Moran; Donncha F O'Brien; Emilie Petit; Jochen H M Prehn; Amaya Sanz-Rodgriguez; David C Henshall
CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.

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2013: Monika A Jarzabek; Emmet McCormack; Jochen H M Prehn; Kai-Ove Skaftnesmo; Rolf Bjerkvig; Patrick Dicker; Peter C Huszthy; Annette T Byrne
In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme.
Molecular imaging 2013;12(3):161-72.
2013: Ujval Anilkumar; Caoimhín G Concannon; Heiko Düssmann; Hans-Georg König; Petronela Weisová; Jochen H M Prehn
AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.
Journal of neurochemistry 2013;124(5):721-34.
2013: Tobias Engel; Michael A Farrell; Caoimhin G Concannon; Norman Delanty; Eva M Jimenez-Mateos; Alba Jimenez-Pacheco; Jose J Lucas; Guillaume Mesuret; Catherine Moran; Donncha F O'Brien; Emilie Petit; Jochen H M Prehn; Amaya Sanz-Rodgriguez; David C Henshall
CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.
Brain : a journal of neurology 2013;136(Pt 2):577-92.
2013: Andreas U Lindner; Fabien Llambi; Deborah A McNamara; Frank Murray; Deborah Ryan; Karen Boland; Gerhardt J Boukes; Mary D Cannon; Caoimhín G Concannon; Douglas R Green; Suzanne Hector; Heinrich J Huber; Elaine W Kay; Joan Kehoe; Jochen H M Prehn
Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.
Cancer research 2013;73(2):519-28.
2012: Hans-Georg König; Robert F Schwamborn; Tytus Bernas; Jennifer C Byrne; Beau J Fenner; Caroline A Jefferies; Jochen H M Prehn
Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons.
Journal of cell science 2012;125(Pt 24):6058-70.
2012: Jasmin Schmid; Gerhardt J Boukes; Heiko Dussmann; Lorna Flanagan; Andreas U Lindner; Carla L O'Connor; Jochen H M Prehn; Markus Rehm; Heinrich J Huber
Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.
The Journal of biological chemistry 2012;287(49):41546-59.
2012: D Davila; H Dussmann; Heinrich J Huber; H Bonner; Caoimhín G Concannon; N M C Connolly; P Weisová; Jochen H M Prehn
Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate.
Cell death and differentiation 2012;19(10):1677-88.
2012: Donat Kögel; Hildegard König; Thorsten Müller; Simone Poeschel; Caroline Bonner; Steffi Chang; Caoimhín G Concannon; Rupert Egensperger; Jochen H M Prehn
The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis.
Neurobiology of aging 2012;33(9):2200-9.
2012: Niamh McCawley; Deborah A McNamara; Jochen H M Prehn; Susan Conlon; Robert J Cummins; Patrick Dicker; Suzanne Hector; Patrick G Johnston; Elaine W Kay; Caoimhín G Concannon
Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer.
International journal of cancer. Journal international du cancer 2012;131(4):E494-500.
2012: Petronela Weisová; Ujval Anilkumar; Caoimhín G Concannon; Jochen H M Prehn; Caitriona Ryan; Manus W Ward
'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.
Biochimica et biophysica acta 2012;1817(5):744-53.
2012: Suzanne Hector; Heinrich J Huber; Elaine W Kay; Joan Kehoe; Niamh McCawley; Deborah McNamara; Frank Murray; Caoimhin G Concannon; Patrick Dicker; Markus Rehm; Jasmin Schmid; Jochen H M Prehn
Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy.
Gut 2012;61(5):725-33.
2012: Maike A Laussmann; Egle Passante; Jochen H M Prehn; Lorna Flanagan; Christian T Hellwig; Heinrich J Huber; Bartlomiej Tomiczek; Markus Rehm
Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.
The Journal of biological chemistry 2012;287(18):14402-11.
2012: Alexandra Skorupa; Isabela M Aparicio; Bridget Breen; Caoimhin G Concannon; Karen Coughlan; Heiko Dussmann; Dairin Kieran; Matthew A King; Philippe Marin; Jochen H M Prehn
Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(15):5024-38.
2012: Suzanne Hector; Gregor Kijanka; Frank Murray; Hong Chen; Jochen H M Prehn
A reverse-ELISA for the detection of TRIM28/KAP1 serum autoantibodies in colorectal cancer patients.
Acta oncologica (Stockholm, Sweden) 2012;51(3):394-6.
2012: Heinrich J Huber; Niamh M C Connolly; Heiko Dussmann; Jochen H M Prehn
A structured approach to the study of metabolic control principles in intact and impaired mitochondria.
Molecular bioSystems 2012;8(3):828-42.
2012: Beatrice D'Orsi; Heiko Düssmann; Helena Bonner; Michael J Courtney; Liam P Tuffy; Manus W Ward; Ina Woods; Jochen H M Prehn
Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(5):1847-58.
2012: Isabela M Aparicio-Erriu; Jochen H M Prehn
Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase.
Frontiers in neuroscience 2012;6():167.
2012: Crina-Maria Ionescu; Jochen H M Prehn; Radka Svobodová Vařeková; Heinrich J Huber; Jaroslav Koča
Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation.
PLoS computational biology 2012;8(6):e1002565.
2011: Angela M Farrelly; Seán M Kilbride; Jochen H M Prehn; Caroline Bonner; Maria M Byrne
Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells.
Apoptosis : an international journal on programmed cell death 2011;16(11):1128-37.
2011: M A Laussmann; Egle Passante; Jochen H M Prehn; J A Rauen; M E Delgado; Marc Devocelle; Heiko Düssmann; M L Würstle; Markus Rehm
Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.
Cell death and differentiation 2011;18(10):1584-97.
2011: Caroline Bonner; Maria M Byrne; Caoimhín G Concannon; Heiko Dussmann; Angela M Farrelly; Donat Kögel; Hans-Georg König; Marjan Rupnik; Isabelle Virard; Hella Wobser; Claes B Wollheim; Mathurin Baquié; Jochen H M Prehn
Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.
The Journal of biological chemistry 2011;286(29):25719-28.
2011: Petronela Weisová; David Dávila; Liam P Tuffy; Manus W Ward; Caoimhín G Concannon; Jochen H M Prehn
Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.
Antioxidants & redox signaling 2011;14(10):1863-76.
2011: Tobias Engel; Nikolaus Plesnila; Jochen H M Prehn; David C Henshall
In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(5):1196-210.
2011: Heinrich J Huber; Heiko Duessmann; Jakub Wenus; Seán M Kilbride; Jochen H M Prehn
Mathematical modelling of the mitochondrial apoptosis pathway.
Biochimica et biophysica acta 2011;1813(4):608-15.
2011: Heinrich J Huber; Heiko Dussmann; Seán M Kilbride; Markus Rehm; Jochen H M Prehn
Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release.
Molecular systems biology 2011;7():470.
2011: Takuro Tsuchiya; Helena P Bonner; Tobias Engel; Ina Woods; Satoshi Matsushima; Manus W Ward; Waro Taki; David C Henshall; Caoimhín G Concannon; Jochen H M Prehn
Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.
The European journal of neuroscience 2011;33(3):401-8.
2010: Liam P Tuffy; Caoimhín G Concannon; Beatrice D'Orsi; Matthew A King; Ina Woods; Heinrich J Huber; Manus W Ward; Jochen H M Prehn
Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.
Molecular and cellular biology 2010;30(23):5484-501.
2010: Seán M Kilbride; Angela M Farrelly; Caroline Bonner; Manus W Ward; Kristine C Nyhan; Caoimhín G Concannon; Claes B Wollheim; Maria M Byrne; Jochen H M Prehn
AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.
The Journal of biological chemistry 2010;285(46):36199-206.
2010: Eva C Bunk; Hans-Georg König; Helena P Bonner; Brian P Kirby; Jochen H M Prehn
NMDA-induced injury of mouse organotypic hippocampal slice cultures triggers delayed neuroblast proliferation in the dentate gyrus: an in vitro model for the study of neural precursor cell proliferation.
Brain research 2010;1359():22-32.
2010: Caroline Bonner; Siobhán Bacon; Caoimhín G Concannon; Syed R Rizvi; Mathurin Baquié; Angela M Farrelly; Seán M Kilbride; Heiko Dussmann; Manus W Ward; Chantal M Boulanger; Claes B Wollheim; Rolf Graf; Maria M Byrne; Jochen H M Prehn
INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.
Diabetes 2010;59(11):2799-808.
2010: Tobias Engel; Aurelien Caballero-Caballero; Clara K Schindler; Nikolaus Plesnila; Andreas Strasser; Jochen H M Prehn; David C Henshall
BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor.
Journal of neurochemistry 2010;115(1):92-101.
2010: Alexander V Zhdanov; Manus W Ward; Cormac T Taylor; Ekaterina A Souslova; Dmitri M Chudakov; Jochen H M Prehn; Dmitri B Papkovsky
Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange.
Biochimica et biophysica acta 2010;1797(9):1627-37.
2010: Julia Strathmann; Karin Klimo; Sven W Sauer; Jürgen G Okun; Jochen H M Prehn; Clarissa Gerhäuser
Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(8):2938-50.
2010: Helena P Bonner; Caoimhín G Concannon; Caroline Bonner; Ina Woods; Manus W Ward; Jochen H M Prehn
Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability.
Journal of neurochemistry 2010;114(2):606-16.
2010: T Engel; S Hatazaki; K Tanaka; Jochen H M Prehn; David C Henshall
Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus.
Neuroscience 2010;168(2):443-50.
2010: Edward W Dervan; Hong Chen; Su Ling Ho; Nikola Brummel; Jasmin Schmid; David Toomey; Margarita Haralambova; Edith Gould; Deborah M Wallace; Jochen H M Prehn; Colm J O'Brien; Derek Murphy
Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma.
Investigative ophthalmology & visual science 2010;51(6):2968-75.
2010: Caoimhín G Concannon; Liam P Tuffy; Petronela Weisová; Helena P Bonner; David Dávila; Caroline Bonner; Marc C Devocelle; Andreas Strasser; Manus W Ward; Jochen H M Prehn
AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis.
The Journal of cell biology 2010;189(1):83-94.
2010: Manus W Ward; Caoimhín G Concannon; Jacqueline Whyte; Ciara M Walsh; Brian Corley; Jochen H M Prehn
The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics.
Journal of neurochemistry 2010;113(1):275-84.
2010: Tobias Engel; Brona M Murphy; Seiji Hatazaki; Eva M Jimenez-Mateos; Caoimhin G Concannon; Ina Woods; Jochen H M Prehn; David C Henshall
Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(3):853-61.
2010: Brona M Murphy; T Engel; A Paucard; S Hatazaki; G Mouri; K Tanaka; L P Tuffy; E M Jimenez-Mateos; I Woods; Mark dunleavy; H P Bonner; Robert Meller; Roger P. Simon; A Strasser; Jochen H M Prehn; David C Henshall
Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.
Cell death and differentiation 2010;17(3):459-68.
2010: Heiko Düssmann; Markus Rehm; Caoimhín G Concannon; S Anguissola; M Würstle; S Kacmar; P Völler; Heinrich J Huber; Jochen H M Prehn
Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.
Cell death and differentiation 2010;17(2):278-90.
2010: T Engel; K Tanaka; E M Jimenez-Mateos; A Caballero-Caballero; Jochen H M Prehn; David C Henshall
Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus.
Cell death & disease 2010;1():e79.
2010: L Flanagan; J Sebastià; L P Tuffy; A Spring; A Lichawska; M Devocelle; Jochen H M Prehn; Markus Rehm
XIAP impairs Smac release from the mitochondria during apoptosis.
Cell death & disease 2010;1():e49.
2010: E C Bunk; Hans-Georg König; T Bernas; T Engel; David C Henshall; B P Kirby; Jochen H M Prehn
BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus.
Cell death & disease 2010;1():e15.
2010: Beau J Fenner; Michael Scannell; Jochen H M Prehn
Expanding the substantial interactome of NEMO using protein microarrays.
PloS one 2010;5(1):e8799.
2009: Sergio Anguissola; Barbara Köhler; Robert O'Byrne; Heiko Düssmann; Mary D Cannon; Frank E Murray; Caoimhin G Concannon; Markus Rehm; Donat Kögel; Jochen H M Prehn
Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.
Molecular pharmacology 2009;76(5):998-1010.
2009: Jordi Sebastià; Dairin Kieran; B Breen; Matthew King; D F Netteland; D Joyce; S F Fitzpatrick; C T Taylor; Jochen H M Prehn
Angiogenin protects motoneurons against hypoxic injury.
Cell death and differentiation 2009;16(9):1238-47.
2009: Beau J Fenner; Michael Scannell; Jochen H M Prehn
Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.
Biochimica et biophysica acta 2009;1794(7):1010-6.
2009: Suzanne Hector; Jochen H M Prehn
Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review.
Biochimica et biophysica acta 2009;1795(2):117-29.
2009: M Rehm; H J Huber; C T Hellwig; S Anguissola; H Dussmann; Jochen H M Prehn
Dynamics of outer mitochondrial membrane permeabilization during apoptosis.
Cell death and differentiation 2009;16(4):613-23.
2009: Petronela Weisová; Caoimhín G Concannon; Marc Devocelle; Jochen H M Prehn; Manus W Ward
Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(9):2997-3008.
2009: Katsura Kuroki; Isabelle Virard; Caoimhin G Concannon; Tobias Engel; Ina Woods; Waro Taki; Nikolaus Plesnila; David C Henshall; Jochen H M Prehn
Effects of transient focal cerebral ischemia in mice deficient in puma.
Neuroscience letters 2009;451(3):237-40.
2008: Matthew King; Christoph G Goemans; FB Hafiz; Jochen H M Prehn; Andreas Wyttenbach; Aviva M Tolkovsky
Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(53):14401-15.
2008: Dairín Kieran; Jordi Sebastià; Matthew J Greenway; Matthew King; Dervla Connaughton; Caoimhin G Concannon; Beau Fenner; Orla Hardiman; Jochen H M Prehn
Control of motoneuron survival by angiogenin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(52):14056-61.
2008: Eva M Jimenez-Mateos; Seiji Hatazaki; Martha B Johnson; Carmen Bellver-Estelles; Genshin Mouri; Caroline Bonner; Jochen H M Prehn; Robert Meller; Roger P. Simon; David C Henshall
Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways.
Neurobiology of disease 2008;32(3):442-53.
2008: Carla L O'Connor; Sergio Anguissola; Heinrich J Huber; Heiko Dussmann; Jochen H M Prehn; Markus Rehm
Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein.
Biochimica et biophysica acta 2008;1783(10):1903-13.
2008: Holger Hetschko; Valerie Voss; Christian Senft; Volker Seifert; Jochen H M Prehn; Donat Kögel
BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells.
Neoplasia (New York, N.Y.) 2008;10(8):873-85.
2008: Christian T Hellwig; Barbara F Kohler; Anna-Kaisa Lehtivarjo; Heiko Dussmann; Michael J Courtney; Jochen H M Prehn; Markus Rehm
Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation.
The Journal of biological chemistry 2008;283(31):21676-85.
2008: Niamh Murphy; Helena P Bonner; Manus W Ward; Brona M Murphy; Jochen H M Prehn; David C Henshall
Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.
Journal of neurochemistry 2008;106(2):978-88.
2008: Caoimhín G Concannon; Manus W Ward; Helena P Bonner; Katsura Kuroki; Liam Tuffy; Caroline Bonner; Ina Woods; Tobias Engel; David C Henshall; Jochen H M Prehn
NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner.
Journal of neurochemistry 2008;105(3):891-903.
2008: Holger Hetschko; Valerie Voss; Volker Seifert; Jochen H M Prehn; Donat Kögel
Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis.
The FEBS journal 2008;275(8):1925-36.
2008: M Gomez-Lazaro; Joaquin Jordan; Caoimhín G Concannon; Miguel F Segura; Francisco J Fernandez-Gomez; Nuria Llecha; Joan X Comella; Jochen H M Prehn; Joaquin Jordan
6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.
Journal of neurochemistry 2008;104(6):1599-612.
2008: Alexander V Zhdanov; Manus W Ward; Jochen H M Prehn; Dmitri B Papkovsky
Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.
The Journal of biological chemistry 2008;283(9):5650-61.
2008: Holger Hetschko; Valerie Voss; Sigrid Horn; Volker Seifert; Jochen H M Prehn; Donat Kögel
Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma.
Journal of neuro-oncology 2008;86(3):265-72.
2008: Barbara Köhler; Sergio Anguissola; Caoimhin G Concannon; Markus Rehm; Donat Kögel; Jochen H M Prehn
Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects.
PloS one 2008;3(7):e2844.
2007: Dairin Kieran; Ina Woods; Andreas Villunger; Andreas Strasser; Jochen H M Prehn
Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20606-11.
2007: S Hatazaki; C Bellver-Estelles; E M Jimenez-Mateos; Robert Meller; Caroline Bonner; N Murphy; S Matsushima; W Taki; Jochen H M Prehn; Roger P. Simon; David C Henshall
Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning.
Neuroscience 2007;150(2):467-77.
2007: Anne Zuse; Helge Prinz; Klaus Müller; Peter Schmidt; Eckhard G Günther; Frank Schweizer; Jochen H M Prehn; Marek Los
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity.
European journal of pharmacology 2007;575(1-3):34-45.
2007: Brona Murphy; Mark Dunleavy; Sachiko Shinoda; Clara Schindler; Robert Meller; Carmen Bellver-Estelles; Seiji Hatazaki; Patrick Dicker; Akitaka Yamamoto; Ina Koegel; Xiangping Chu; Weizhen Wang; Zhigang Xiong; Jochen H M Prehn; Roger P. Simon; David C Henshall
Bcl-w protects hippocampus during experimental status epilepticus.
The American journal of pathology 2007;171(4):1258-68.
2007: Simon Cronin; Matthew J Greenway; Jochen H M Prehn; Orla Hardiman
Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2007;78(9):984-6.
2007: Manus W Ward; Heinrich J Huber; Petronela Weisová; Heiko Düssmann; David G Nicholls; Jochen H M Prehn
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(31):8238-49.
2007: Caoimhin G Concannon; B F Koehler; Claus Reimertz; B M Murphy; Caroline Bonner; N Thurow; Manus W Ward; Andreas Villunger; A Strasser; Donat Kögel; Jochen H M Prehn
Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway.
Oncogene 2007;26(12):1681-92.
2007: Heinrich J Huber; Markus Rehm; Martin Plchut; Heiko Düssmann; Jochen H M Prehn
APOPTO-CELL--a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis.
Bioinformatics (Oxford, England) 2007;23(5):648-50.
2007: M Gomez-Lazaro; Joaquin Jordan; R M Melero-Fernandez de Mera; F J Fernandez-Gómez; Caoimhin G Concannon; M F Segura; Joan X Comella; Jochen H M Prehn; J Jordan
Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.
Molecular pharmacology 2007;71(3):736-43.
2007: Ekaterini Copanaki; Tina Schürmann; Anne Eckert; Kristina Leuner; Walter E Müller; Jochen H M Prehn; Donat Kögel
The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion.
Biochimica et biophysica acta 2007;1773(2):157-65.
2007: Hans-Georg König; Markus Rehm; Daniel Gudorf; Stan Krajewski; Atan Gross; Manus W Ward; Jochen H M Prehn
Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons.
BMC cell biology 2007;8():7.
2007: Thorsten Müller; Caoimhin G Concannon; Manus W Ward; Ciara M Walsh; Anca L Tirniceriu; Florian Tribl; Donat Kögel; Jochen H M Prehn; Rupert Egensperger
Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).
Molecular biology of the cell 2007;18(1):201-10.
2006: Simon Cronin; Matthew J Greenway; Sean Ennis; Dairin Kieran; Andrew Green; Jochen H M Prehn; Orla Hardiman
Elevated serum angiogenin levels in ALS.
Neurology 2006;67(10):1833-6.
2006: Donat Kögel; Birte Svensson; Ekaterini Copanaki; Sergio Anguissola; Caroline Bonner; Nadia Thurow; Daniel Gudorf; Holger Hetschko; Thorsten Müller; Marion Peters; Hans-Georg König; Jochen H M Prehn
Induction of transcription factor CEBP homology protein mediates hypoglycaemia-induced necrotic cell death in human neuroblastoma cells.
Journal of neurochemistry 2006;99(3):952-64.
2006: Markus Rehm; Heinrich J Huber; Heiko Dussmann; Jochen H M Prehn
Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein.
The EMBO journal 2006;25(18):4338-49.
2006: R Gerlach; G Demel; Hans-Georg König; U Gross; Jochen H M Prehn; Andreas Raabe; Volker Seifert; Donat Kögel
Active secretion of S100B from astrocytes during metabolic stress.
Neuroscience 2006;141(4):1697-701.
2006: Christian Schultz; Hans-Georg König; Domenico Del Turco; Chrisoula Politi; Gunter P Eckert; Estifanos Ghebremedhin; Jochen H M Prehn; Donat Kögel; Thomas Deller
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons.
Molecular and cellular neurosciences 2006;33(1):68-80.
2006: Matthew J Greenway; Peter M Andersen; Carsten Russ; Sean Ennis; Susan Cashman; Colette Donaghy; Victor Patterson; Robert Swingler; Dairin Kieran; Jochen H M Prehn; Karen E Morrison; Andrew Green; K Ravi Acharya; Robert H Brown; Orla Hardiman
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.
Nature genetics 2006;38(4):411-3.
2006: Clara K Schindler; Erik G Pearson; Helena P Bonner; Norman K So; Roger P. Simon; Jochen H M Prehn; David C Henshall
Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(4):583-9.
2006: Manus W Ward; Markus Rehm; Heiko Duessmann; Slavomir Kacmar; Caoimhin G Concannon; Jochen H M Prehn
Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis.
The Journal of biological chemistry 2006;281(9):5837-44.
2006: Akitaka Yamamoto; Niamh Murphy; Clara K Schindler; Norman K So; Sabine Stohr; Waro Taki; Jochen H M Prehn; David C Henshall
Endoplasmic reticulum stress and apoptosis signaling in human temporal lobe epilepsy.
Journal of neuropathology and experimental neurology 2006;65(3):217-25.
2006: Hella Wobser; Caroline Bonner; J J Nolan; M M Byrne; Jochen H M Prehn
Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function.
Diabetologia 2006;49(3):519-26.
2005: M Gomez-Lazaro; Joaquin Jordan; Francisco J Fernandez-Gomez; Jochen H M Prehn; Joaquín Jordán
Activation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cells.
Experimental neurology 2005;196(1):96-103.
2005: Hans-Georg König; Donat Kögel; Abdelhaq Rami; Jochen H M Prehn
TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling.
The Journal of cell biology 2005;168(7):1077-86.
2005: Donat Kögel; R Schomburg; Ekaterini Copanaki; Jochen H M Prehn
Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway.
Cell death and differentiation 2005;12(1):1-9.
2004: Manus W Ward; Donat Kögel; Jochen H M Prehn
Neuronal apoptosis: BH3-only proteins the real killers?
Journal of bioenergetics and biomembranes 2004;36(4):295-8.
2004: Donat Kögel; Marion Peters; Hans-Georg König; S M A Hashemi; Truc Bui; V Arolt; Matthias Rothermundt; Jochen H M Prehn
S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: Clinical implications for the role of S100B in excitotoxic brain injury.
Neuroscience 2004;127(4):913-20.
2003: Donat Kögel; Robert Schomburg; Tina Schürmann; Claus Reimertz; Hans-Georg König; Monika Poppe; Anne Eckert; Walter E Müller; Jochen H M Prehn
The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis.
Journal of neurochemistry 2003;87(1):248-56.
2003: Markus Rehm; Heiko Düssmann; Jochen H M Prehn
Real-time single cell analysis of Smac/DIABLO release during apoptosis.
The Journal of cell biology 2003;162(6):1031-43.
2003: Claus Reimertz; Donat Kögel; Abdelhaq Rami; Thomas Chittenden; Jochen H M Prehn
Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway.
The Journal of cell biology 2003;162(4):587-97.
2003: Helge Prinz; Yukihito Ishii; Takeo Hirano; Thomas Stoiber; Juan A Camacho Gomez; Peter Schmidt; Heiko Düssmann; Angelika Burger; Jochen H M Prehn; Eckhard G Günther; Eberhard Unger; Kazuo Umezawa
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 2003;46(15):3382-94.
2003: Joaquín Jordán; Valentín Ceña; Jochen H M Prehn
Mitochondrial control of neuron death and its role in neurodegenerative disorders.
Journal of physiology and biochemistry 2003;59(2):129-41.
2003: Matthias Rothermundt; Marion Peters; Jochen H M Prehn; Volker Arolt
S100B in brain damage and neurodegeneration.
Microscopy research and technique 2003;60(6):614-32.
2003: Heiko Düssmann; Donat Kögel; Markus Rehm; Jochen H M Prehn
Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis.
The Journal of biological chemistry 2003;278(15):12645-9.
2003: Heiko Düssmann; Markus Rehm; Donat Kögel; Jochen H M Prehn
Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis.
Journal of cell science 2003;116(Pt 3):525-36.
2003: Donat Kögel; Claus Reimertz; Heiko Düssmann; P Mech; Karl-Heinz Scheidtmann; Jochen H M Prehn
The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis.
European journal of cancer (Oxford, England : 1990) 2003;39(2):249-56.
2002: Birte Svensson; Marion Peters; Hans-Georg König; Monika Poppe; Bodo Levkau; Matthias Rothermundt; Volker Arolt; Donat Kögel; Jochen H M Prehn
Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(10):1170-5.
2002: Monika Poppe; Claus Reimertz; Gudrun Münstermann; Donat Kögel; Jochen H M Prehn
Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression.
Journal of neurochemistry 2002;82(3):482-94.
2002: Markus Rehm; Heiko Dussmann; Reiner U Janicke; Jeremy M Tavare; Donat Kogel; Jochen H M Prehn
Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.
The Journal of biological chemistry 2002;277(27):24506-14.
2002: Truc Bui; Hans-Georg König; Carsten Culmsee; Elke Bauerbach; Monika Poppe; Josef Krieglstein; Jochen H M Prehn
p75 neurotrophin receptor is required for constitutive and NGF-induced survival signalling in PC12 cells and rat hippocampal neurones.
Journal of neurochemistry 2002;81(3):594-605.
2002: Hella Wobser; Heiko Düssmann; Donat Kögel; Haiyan Wang; Claus Reimertz; Claes B Wollheim; Maria M Byrne; Jochen H M Prehn
Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.
The Journal of biological chemistry 2002;277(8):6413-21.
2002: Carsten Culmsee; Norbert Gerling; M Lehmann; M Nikolova-Karakashian; Jochen H M Prehn; Mark P Mattson; Josef Krieglstein
Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.
Neuroscience 2002;115(4):1089-108.
2001: Donat Kögel; Claus Reimertz; P Mech; Monika Poppe; M C Frühwald; Harry Engemann; Karl-Heinz Scheidtmann; Jochen H M Prehn
Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway.
British journal of cancer 2001;85(11):1801-8.
2001: Craig Marc Luetjens; Donat Kögel; Claus Reimertz; Heiko Düssmann; Andrea Renz; Klaus Schulze-Osthoff; Anna-Liisa Nieminen; Monika Poppe; Jochen H M Prehn
Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis.
Molecular pharmacology 2001;60(5):1008-19.
2001: Claus Reimertz; Donat Kögel; S Lankiewicz; Monika Poppe; Jochen H M Prehn
Ca(2+)-induced inhibition of apoptosis in human SH-SY5Y neuroblastoma cells: degradation of apoptotic protease activating factor-1 (APAF-1).
Journal of neurochemistry 2001;78(6):1256-66.
2001: Monika Poppe; Claus Reimertz; Heiko Düssmann; AJ Krohn; Craig Marc Luetjens; D Böckelmann; Anna-Liisa Nieminen; Donat Kögel; Jochen H M Prehn
Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4551-63.
2001: Donat Kögel; Jochen H M Prehn; Karl-Heinz Scheidtmann
The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game.
BioEssays : news and reviews in molecular, cellular and developmental biology 2001;23(4):352-8.
2001: Truc Bui; Antonia Livolsi; Jean-François Peyron; Jochen H M Prehn
Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha.
The Journal of cell biology 2001;152(4):753-64.
2001: Craig Marc Luetjens; S Lankiewicz; Truc Bui; AJ Krohn; Monika Poppe; Jochen H M Prehn
Up-regulation of Bcl-xL in response to subtoxic beta-amyloid: role in neuronal resistance against apoptotic and oxidative injury.
Neuroscience 2001;102(1):139-50.
2000: Craig Marc Luetjens; Truc Bui; B Sengpiel; Gudrun Münstermann; Monika Poppe; AJ Krohn; Elke Bauerbach; Josef Krieglstein; Jochen H M Prehn
Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(15):5715-23.
2000: S Lankiewicz; C Marc Luetjens; N Truc Bui; AJ Krohn; Monika Poppe; Gregory M. Cole; Takaomi C Saido; Jochen H M Prehn
Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death.
The Journal of biological chemistry 2000;275(22):17064-71.
1999: AJ Krohn; T Wahlbrink; Jochen H M Prehn
Mitochondrial depolarization is not required for neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(17):7394-404.
1999: Y Zhu; Jochen H M Prehn; Carsten Culmsee; Josef Krieglstein
The beta2-adrenoceptor agonist clenbuterol modulates Bcl-2, Bcl-xl and Bax protein expression following transient forebrain ischemia.
Neuroscience 1999;90(4):1255-63.
1998: AJ Krohn; E Preis; Jochen H M Prehn
Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8186-97.
1998: B Sengpiel; E Preis; Josef Krieglstein; Jochen H M Prehn
NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria.
The European journal of neuroscience 1998;10(5):1903-10.
1998: Jochen H M Prehn
Mitochondrial transmembrane potential and free radical production in excitotoxic neurodegeneration.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(3):316-22.
1997: Jochen H M Prehn; Joaquín Jordán; Ghanashyam D Ghadge; E Preis; Joaquin Jordan; Raymond P Roos; Josef Krieglstein; Richard J Miller
Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis.
Journal of neurochemistry 1997;68(4):1679-85.
1997: Joaquín Jordán; Joaquin Jordan; Jochen H M Prehn; R R Weichselbaum; M Beckett; Ghanashyam D Ghadge; Raymond P Roos; J M Leiden; Richard J Miller
p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(4):1397-405.
1996: P Henrich-Noack; Jochen H M Prehn; Josef Krieglstein
TGF-beta 1 protects hippocampal neurons against degeneration caused by transient global ischemia. Dose-response relationship and potential neuroprotective mechanisms.
Stroke; a journal of cerebral circulation 1996;27(9):1609-14; discussion 1615.
1996: Jochen H M Prehn
Marked diversity in the action of growth factors on N-methyl-D-aspartate-induced neuronal degeneration.
European journal of pharmacology 1996;306(1-3):81-8.
1996: Jochen H M Prehn; Vytautas P Bindokas; Joaquín Jordán; Joaquin Jordan; Ghanashyam D Ghadge; Raymond P Roos; Lawrence Boise; Craig Thompson; S Krajewski; J C Reed; Richard J Miller
Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.
Molecular pharmacology 1996;49(2):319-28.
1995: J Jordan; Ghanashyam D Ghadge; Jochen H M Prehn; P T Toth; Raymond P Roos; Richard J Miller
Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor.
Molecular pharmacology 1995;47(6):1095-1100.
1995: Jochen H M Prehn; K Lippert; Josef Krieglstein
Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury?
European journal of pharmacology 1995;292(2):179-89.
1994: Jochen H M Prehn; Vytautas P Bindokas; C J Marcuccilli; S Krajewski; J C Reed; Richard J Miller
Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12599-603.
1994: Jochen H M Prehn; Josef Krieglstein
Opposing effects of transforming growth factor-beta 1 on glutamate neurotoxicity.
Neuroscience 1994;60(1):7-10.
1994: B Peruche; C Backhauss; Jochen H M Prehn; Josef Krieglstein
Protective effects of 5-HT1A receptor agonists against neuronal damage demonstrated in vivo and in vitro.
Journal of neural transmission. Parkinson's disease and dementia section 1994;8(1-2):73-83.
1994: P Henrich-Noack; Jochen H M Prehn; Josef Krieglstein
Neuroprotective effects of TGF-beta 1.
Journal of neural transmission. Supplementum 1994;43():33-45.
1993: Jochen H M Prehn; M Welsch; C Backhauss; J Nuglisch; F Ausmeier; C Karkoutly; Josef Krieglstein
Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia.
Brain research 1993;630(1-2):10-20.
1993: Jochen H M Prehn; C Backhauss; Josef Krieglstein
Transforming growth factor-beta 1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(3):521-5.
1993: Jochen H M Prehn; B Peruche; Klaus Unsicker; Josef Krieglstein
Isoform-specific effects of transforming growth factors-beta on degeneration of primary neuronal cultures induced by cytotoxic hypoxia or glutamate.
Journal of neurochemistry 1993;60(5):1665-72.
1993: Jochen H M Prehn; Josef Krieglstein
Platelet-activating factor antagonists reduce excitotoxic damage in cultured neurons from embryonic chick telencephalon and protect the rat hippocampus and neocortex from ischemic injury in vivo.
Journal of neuroscience research 1993;34(2):179-88.
1992: Jochen H M Prehn; C Karkoutly; J Nuglisch; B Peruche; Josef Krieglstein
Dihydrolipoate reduces neuronal injury after cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1992;12(1):78-87.
1991: Jochen H M Prehn; C Backhauss; C Karkoutly; J Nuglisch; B Peruche; C Rossberg; Josef Krieglstein
Neuroprotective properties of 5-HT1A receptor agonists in rodent models of focal and global cerebral ischemia.
European journal of pharmacology 1991;203(2):213-22.