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Marc Prentki

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Julien Lamontagne; S R Murthy Madiraju; Christopher J Nolan; Emilie Pepin; Marie-Line Peyot; Vincent Poitout; Elise Jalbert-Arsenault; Erik Joly; Neil B Ruderman; Marc Prentki
Pioglitazone acutely reduces energy metabolism and insulin secretion in rats.
Jason Talbot; Erik Joly; Marc Prentki; Jean Buteau
β-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic β INS832/13 cells.
José Iglesias; Shawon Lahiri; Angela McDonald; Daniel Metzger; Sylvain Pradevand; Marc Prentki; Frank Reimann; Catherine Roger; Guy A Rutter; Bernard Thorens; David Vallois; Sebastian Barg; Claire Bonal; Pierre Chambon; Marie-Bernard Debril; Fiona Gribble; Pedro Herrera; Akadiri Yessoufou; Walter Wahli
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.

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All Publications

2013: Julien Lamontagne; S R Murthy Madiraju; Christopher J Nolan; Emilie Pepin; Marie-Line Peyot; Vincent Poitout; Elise Jalbert-Arsenault; Erik Joly; Neil B Ruderman; Marc Prentki
Pioglitazone acutely reduces energy metabolism and insulin secretion in rats.
Diabetes 2013;62(6):2122-9.
2012: Jason Talbot; Erik Joly; Marc Prentki; Jean Buteau
β-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic β INS832/13 cells.
Molecular and cellular endocrinology 2012;364(1-2):65-70.
2012: José Iglesias; Shawon Lahiri; Angela McDonald; Daniel Metzger; Sylvain Pradevand; Marc Prentki; Frank Reimann; Catherine Roger; Guy A Rutter; Bernard Thorens; David Vallois; Sebastian Barg; Claire Bonal; Pierre Chambon; Marie-Bernard Debril; Fiona Gribble; Pedro Herrera; Akadiri Yessoufou; Walter Wahli
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.
The Journal of clinical investigation 2012;122(11):4105-17.
2012: Cécile Jacovetti; Jean-Christophe Jonas; R Laybutt; Emmanuelle Meugnier; Géraldine Parnaud; Marie-Line Peyot; Marc Prentki; Amar Abderrahmani; Domenico Bosco; Marion Cornu; Sophie Rome; Bernard Thorens; Romano Regazzi
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity.
The Journal of clinical investigation 2012;122(10):3541-51.
2012: Mourad Ferdaoussi; J Fielitz; J Kolic; Patrick E MacDonald; E N Olson; V Bergeron; T Biden; J Cantley; Marc Prentki; B Zarrouki; Vincent Poitout
G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.
Diabetologia 2012;55(10):2682-92.
2012: Marc Prentki; S R Murthy Madiraju
Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes.
Molecular and cellular endocrinology 2012;353(1-2):88-100.
2011: Christopher J Nolan; Peter Damm; Marc Prentki
Type 2 diabetes across generations: from pathophysiology to prevention and management.
Lancet 2011;378(9786):169-81.
2010: G Fontés; B Zarrouki; derek hagman; Martin G Latour; M Semache; V Roskens; P C Moore; Marc Prentki; C J Rhodes; T L Jetton; Vincent Poitout
Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
Diabetologia 2010;53(11):2369-79.
2010: Emilie Pepin; Claudiane Guay; Viviane Delghingaro-Augusto; Erik Joly; S R Murthy Madiraju; Marc Prentki
Short-chain 3-hydroxyacyl-CoA dehydrogenase is a negative regulator of insulin secretion in response to fuel and non-fuel stimuli in INS832/13 β-cells.
Journal of diabetes 2010;2(3):157-67.
2010: Marie-Line Peyot; Emilie Pepin; Julien Lamontagne; Martin G Latour; Bader Zarrouki; Roxane Lussier; Marco Pineda; Thomas L Jetton; S R Murthy Madiraju; Erik Joly; Marc Prentki
Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.
Diabetes 2010;59(9):2178-87.
2010: Wissal El-Assaad; Erik Joly; Annie Barbeau; Robert Sladek; Jean Buteau; Isabel Maestre; Emilie Pepin; Shangang Zhao; José Iglesias; Enrique Roche; Marc Prentki
Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells.
Endocrinology 2010;151(7):3061-73.
2009: Erik Joly; Raphael Roduit; Marie-Line Peyot; Susan Amy Habinowski; Neil Bertrand Ruderman; Lee Alan Witters; Marc Prentki
Glucose represses PPARα gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cell.
Journal of diabetes 2009;1(4):263-72.
2009: Thierry Ntimbane; Blandine Comte; Geneviève Mailhot; Yves Berthiaume; Vincent Poitout; Marc Prentki; Rémi Rabasa-Lhoret; Emile Levy
Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress.
The Clinical biochemist. Reviews / Australian Association of Clinical Biochemists 2009;30(4):153-77.
2009: Thierry Alquier; Marie-Line Peyot; Martin G Latour; Melkam Kebede; Christina M Sorensen; Stephane Gesta; C Ronald Kahn; Richard D Smith; Thomas L Jetton; Thomas O Metz; Marc Prentki; Vincent Poitout
Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.
Diabetes 2009;58(11):2607-15.
2009: Moise Bendayan; Irene Londono; Bruce E Kemp; Grahame D Hardie; Neil Ruderman; Marc Prentki
Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009;57(10):963-71.
2009: Padma Madiraju; Shri V Pande; Marc Prentki; S R Murthy Madiraju
Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation.
Epigenetics : official journal of the DNA Methylation Society 2009;4(6):399-403.
2009: Julien Lamontagne; Emilie Pepin; Marie-Line Peyot; Erik Joly; Neil B Ruderman; Vincent Poitout; S R Murthy Madiraju; Christopher J Nolan; Marc Prentki
Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.
Endocrinology 2009;150(8):3465-74.
2009: Marie-Line Peyot; Claudiane Guay; Martin G Latour; Julien Lamontagne; Roxane Lussier; Marco Pineda; Neil B Ruderman; Guenter Haemmerle; Rudolf Zechner; Erik Joly; S R Murthy Madiraju; Vincent Poitout; Marc Prentki
Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.
The Journal of biological chemistry 2009;284(25):16848-59.
2009: Despina Harbilas; Louis C Martineau; Cory S Harris; Danielle C A Adeyiwola-Spoor; Ammar Saleem; Jennifer Lambert; Dayna Caves; Timothy Johns; Marc Prentki; Alain Cuerrier; John T Arnason; Steffany A L Bennett; Pierre S Haddad
Evaluation of the antidiabetic potential of selected medicinal plant extracts from the Canadian boreal forest used to treat symptoms of diabetes: part II.
Canadian journal of physiology and pharmacology 2009;87(6):479-92.
2009: Viviane Delghingaro-Augusto; Christopher J Nolan; D Gupta; T L Jetton; M G Latour; M Peshavaria; S R Murthy Madiraju; Erik Joly; M-L Peyot; Marc Prentki; J Leahy
Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.
Diabetologia 2009;52(6):1122-32.
2009: Marie-Line Peyot; Joshua P Gray; Julien Lamontagne; Peter J S Smith; George G Holz; S R Murthy Madiraju; Marc Prentki; Emma Heart
Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.
PloS one 2009;4(7):e6221.
2008: Christopher J Nolan; Marc Prentki
The islet beta-cell: fuel responsive and vulnerable.
Trends in endocrinology and metabolism: TEM 2008;19(8):285-91.
2008: Marc Prentki; S R Murthy Madiraju
Glycerolipid metabolism and signaling in health and disease.
Endocrine reviews 2008;29(6):647-76.
2008: Patrice Dallaire; Kerstin Bellmann; Mathieu Laplante; Stéphanie Gélinas; Carolina Centeno-Baez; Patrice Penfornis; Marie-Line Peyot; Martin G Latour; Julien Lamontagne; Maria E Trujillo; Philipp E Scherer; Marc Prentki; Yves Deshaies; André Marette
Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism.
Diabetes 2008;57(8):1999-2011.
2008: Kathrin Maedler; Fabienne T Schulthess; Christelle Bielman; Thierry Berney; Christophe Bonny; Marc Prentki; Marc Y Donath; Raphael Roduit
Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1905-13.
2007: Claudiane Guay; S R Murthy Madiraju; Alexandre Aumais; Erik Joly; Marc Prentki
A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion.
The Journal of biological chemistry 2007;282(49):35657-65.
2007: Ewa Przybytkowski; Erik Joly; Christopher J Nolan; Serge Hardy; Ann-Michele Francoeur; Yves Langelier; Marc Prentki
Upregulation of cellular triacylglycerol - free fatty acid cycling by oleate is associated with long-term serum-free survival of human breast cancer cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2007;85(3):301-10.
2007: Julien Lamontagne; Pellegrino Masiello; Mariannick Marcil; Viviane Delghingaro-Augusto; Yan Burelle; Marc Prentki; Christopher J Nolan
Circulating lipids are lowered but pancreatic islet lipid metabolism and insulin secretion are unaltered in exercise-trained female rats.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2007;32(2):241-8.
2007: Robert Sladek; Ghislain Rocheleau; Johan Rung; Christian Dina; Lishuang Shen; david serre; Philippe Boutin; Daniel Vincent; Alexandre Belisle; Samy HADJADJ; Beverley Balkau; Barbara Heude; Guillaume Charpentier; Thomas J Hudson; Alexandre Montpetit; Alexey V Pshezhetsky; Marc Prentki; Barry Posner; David J Balding; David Meyre; Constantin Polychronakos; philippe froguel
A genome-wide association study identifies novel risk loci for type 2 diabetes.
Nature 2007;445(7130):881-5.
2006: Christopher J Nolan; Murthy S R Madiraju; Viviane Delghingaro-Augusto; Marie-Line Peyot; Marc Prentki
Fatty acid signaling in the beta-cell and insulin secretion.
Diabetes 2006;55 Suppl 2():S16-23.
2006: Louis C Martineau; Audrey Couture; Danielle Spoor; Ali Benhaddou-Andaloussi; Cory Harris; Bouchra MEDDAH; Charles Leduc; Andrew Burt; Tri Vuong; Phuong Mai Le; Marc Prentki; Steffany A L Bennett; John T Arnason; Pierre S Haddad
Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2006;13(9-10):612-23.
2006: Christopher J Nolan; J L Leahy; Viviane Delghingaro-Augusto; Jacob A Moibi; Krishnakant Soni; Marie-Line Peyot; Mélanie Fortier; C Guay; J Lamontagne; A Barbeau; Ewa Przybytkowski; Erik Joly; Pellegrino Masiello; S Wang; Grant A Mitchell; Marc Prentki
Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.
Diabetologia 2006;49(9):2120-30.
2006: Danielle C A Spoor; Louis C Martineau; Charles Leduc; Ali Benhaddou-Andaloussi; Bouchra MEDDAH; Cory Harris; Andrew Burt; Marie-Hélène Fraser; Jason Coonishish; Erik Joly; Alain Cuerrier; Steffany A L Bennett; Timothy Johns; Marc Prentki; John T Arnason; Pierre S Haddad
Selected plant species from the Cree pharmacopoeia of northern Quebec possess anti-diabetic potential.
Canadian journal of physiology and pharmacology 2006;84(8-9):847-58.
2006: Marc Prentki; Christopher J Nolan
Islet beta cell failure in type 2 diabetes.
The Journal of clinical investigation 2006;116(7):1802-12.
2006: Edwin P Kwan; Li Xie; Laura Sheu; Christopher J Nolan; Marc Prentki; Andrea Betz; Nils Brose; Herbert Y Gaisano
Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance.
Diabetes 2006;55(5):1421-9.
2006: Claire Cheyssac; Christian Dina; frederic lepretre; Valérie Vasseur-Delannoy; Aurélie Dechaume; Stéphane Lobbens; Beverley Balkau; Juan Ruiz; Guillaume Charpentier; François Pattou; Erik Joly; Marc Prentki; Torben Hansen; Oluf Pedersen; Martine Vaxillaire; philippe froguel
EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families.
Diabetes 2006;55(4):1171-6.
2005: Erik Joly; Moise Bendayan; Raphael Roduit; Asish K Saha; Neil B Ruderman; Marc Prentki
Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes.
FEBS letters 2005;579(29):6581-6.
2005: Zhiyuan Hu; Yun Dai; Marc Prentki; Shigeru Chohnan; M Daniel Lane
A role for hypothalamic malonyl-CoA in the control of food intake.
The Journal of biological chemistry 2005;280(48):39681-3.
2005: Liping Hu; Jude T Deeney; Christopher J Nolan; Marie-Line Peyot; Ada Ao; Ann-Marie T Richard; Esthere Luc; Nils Færgeman; Jens Knudsen; Wen Guo; Maria Sorhede-Winzell; Marc Prentki; Barbara E Corkey
Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes.
American journal of physiology. Endocrinology and metabolism 2005;289(6):E1085-92.
2005: Murwarid M Assifi; Gabriela Suchankova; Scarlet Constant; Marc Prentki; Asish K Saha; Neil B Ruderman
AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats.
American journal of physiology. Endocrinology and metabolism 2005;289(5):E794-800.
2005: So-Young Park; Hyo-Jeong Kim; Shupei Wang; Takamasa Higashimori; Jianying Dong; Yoon-Jung Kim; Gary W Cline; Hong Li; Marc Prentki; Gerald I Shulman; Grant A Mitchell; Jason K Kim
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.
American journal of physiology. Endocrinology and metabolism 2005;289(1):E30-9.
2005: Amélie Pelletier; Erik Joly; Marc Prentki; Lise Coderre
Adenosine 5'-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes.
Endocrinology 2005;146(5):2285-94.
2005: Serge Hardy; Geneviève G St-Onge; Erik Joly; Yves Langelier; Marc Prentki
Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.
The Journal of biological chemistry 2005;280(14):13285-91.
2005: Bernadette Neve; Martin E Fernandez Zapico; Vered Ashkenazi-Katalan; Christian Dina; Yasmin H Hamid; Erik Joly; Emmanuel Vaillant; Yamina Benmezroua; Emmanuelle Durand; Nicolas Bakaher; Valérie Delannoy; Martine Vaxillaire; Tiffany Cook; Geesje M Dallinga-Thie; Hans Jansen; Marie-Aline Charles; Karine Clément; Pilar Galan; Serge Hercberg; Nicole Helbecque; Guillaume Charpentier; Marc Prentki; Torben Hansen; Oluf Pedersen; Raul Urrutia; Danielle Melloul; philippe froguel
Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4807-12.
2005: Laura Herrero; Blanca Rubí; David Sebastián; Dolors Serra; Guillermina Asins; Pierre Maechler; Marc Prentki; Fausto G Hegardt
Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.
Diabetes 2005;54(2):462-71.
2005: Sandrine Gremlich; Christopher Nolan; Raphael Roduit; Rémy Burcelin; Marie-Line Peyot; Viviane Delghingaro-Augusto; Béatrice Desvergne; Liliane Michalik; Marc Prentki; Walter Wahli
Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation.
Endocrinology 2005;146(1):375-82.
2004: Lawrence Rosenberg; Mark Lipsett; Ji-Won Yoon; Marc Prentki; Rennian Wang; Hee-Sook Jun; Gary L Pittenger; David Taylor-Fishwick; Aaron I Vinik
A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice.
Annals of surgery 2004;240(5):875-84.
2004: Marie-Line Peyot; Christopher J Nolan; Krishnakant Soni; Erik Joly; Roxane Lussier; Barbara E Corkey; Shu Pei Wang; Grant A Mitchell; Marc Prentki
Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1.
Diabetes 2004;53(7):1733-42.
2004: Matthew G Hartman; Dan Lu; Mi-Lyang Kim; Gary J Kociba; Tala Shukri; Jean Buteau; Xiaozhong Wang; Wendy L Frankel; Denis C Guttridge; Marc Prentki; Shane T Grey; David Ron; Tsonwin Hai
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis.
Molecular and cellular biology 2004;24(13):5721-32.
2004: Jean Buteau; Wissal El-Assaad; C J Rhodes; Lawrence Rosenberg; Erik Joly; Marc Prentki
Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
Diabetologia 2004;47(5):806-15.
2004: Neil B Ruderman; Marc Prentki
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome.
Nature reviews. Drug discovery 2004;3(4):340-51.
2004: Raphael Roduit; Christopher Nolan; Cristina Alarcon; Patrick Moore; Annie Barbeau; Viviane Delghingaro-Augusto; Ewa Przybykowski; Johane Morin; Frédéric Massé; Bernard Massie; Neil B Ruderman; Christopher Rhodes; Vincent Poitout; Marc Prentki
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
Diabetes 2004;53(4):1007-19.
2003: Wissal El-Assaad; Jean Buteau; Marie-Line Peyot; Christopher Nolan; Raphael Roduit; Serge Hardy; Erik Joly; Ghassan Dbaibo; Lawrence Rosenberg; Marc Prentki
Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.
Endocrinology 2003;144(9):4154-63.
2003: Serge Hardy; Wissal El-Assaad; Ewa Przybytkowski; Erik Joly; Marc Prentki; Yves Langelier
Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin.
The Journal of biological chemistry 2003;278(34):31861-70.
2003: Neil B Ruderman; H Park; Virendar K Kaushik; D Dean; Scarlet Constant; Marc Prentki; Asish K Saha
AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.
Acta physiologica Scandinavica 2003;178(4):435-42.
2003: Jean Buteau; Sylvain Foisy; Erik Joly; Marc Prentki
Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor.
Diabetes 2003;52(1):124-32.
2003: Isabel Maestre; Joaquín Jordán; soledad calvo; Juan Antonio Reig; Valentín Ceña; Bernat Soria; Marc Prentki; Enrique Roche
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.
Endocrinology 2003;144(1):335-45.
2002: Marc Prentki; Erik Joly; Wissal El-Assaad; Raphael Roduit
Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes.
Diabetes 2002;51 Suppl 3():S405-13.
2002: Haejoe Park; Virendar K Kaushik; Scarlet Constant; Marc Prentki; Ewa Przybytkowski; Neil B Ruderman; Asish K Saha
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise.
The Journal of biological chemistry 2002;277(36):32571-7.
2002: Cristina Alarcon; Barton Wicksteed; Marc Prentki; Barbara E Corkey; Christopher J Rhodes
Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
Diabetes 2002;51(8):2496-504.
2002: Timothy M Mason; B Chan; B El-Bahrani; Tracy Goh; Neehar Gupta; J Gamble; Z Qing Shi; Marc Prentki; George Steiner; Adria Giacca
The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats.
Atherosclerosis 2002;161(2):345-52.
2002: Pellegrino Masiello; Michela Novelli; M Bombara; Vanna Fierabracci; Simona Vittorini; Marc Prentki; Ettore Bergamini
The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat islets.
Metabolism: clinical and experimental 2002;51(1):110-4.
2001: Jean Buteau; Sylvain Foisy; C J Rhodes; Lee Carpenter; Trevor J Biden; Marc Prentki
Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
Diabetes 2001;50(10):2237-43.
2001: Raphael Roduit; Pellegrino Masiello; Shu Pei Wang; H Li; Grant A Mitchell; Marc Prentki
A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in hormone-sensitive lipase-deficient mice.
Diabetes 2001;50(9):1970-5.
2001: Nathalie Davis-Lameloise; Patrick Muzzin; Marc Prentki; Françoise Assimacopoulos-Jeannet
Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?
Diabetes 2001;50(4):803-9.
2001: F Caserta; Tamara Tchkonia; Vildan N. Civelek; Marc Prentki; Nicholas F Brown; J Denis McGarry; R Armour Forse; Barbara E Corkey; James A Hamilton; James L Kirkland
Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes.
American journal of physiology. Endocrinology and metabolism 2001;280(2):E238-47.
2000: Joseph S Dillon; Gordon C Yaney; Y Zhou; N Voilley; S Bowen; S Chipkin; C R Bliss; Vera Schultz; F C Schuit; Marc Prentki; D J Waxman; Barbara E Corkey
Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.
Diabetes 2000;49(12):2012-20.
2000: Raphael Roduit; J Morin; F Massé; L Segall; E Roche; Christopher B Newgard; Françoise Assimacopoulos-Jeannet; Marc Prentki
Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell.
The Journal of biological chemistry 2000;275(46):35799-806.
2000: Serge Hardy; Yves Langelier; Marc Prentki
Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects.
Cancer research 2000;60(22):6353-8.
2000: Jason R B Dyck; Luc G Berthiaume; Panakkezhum D Thomas; PF Kantor; Amy J Barr; Rick Barr; D Singh; Teresa A Hopkins; N Voilley; Marc Prentki; Gary D Lopaschuk
Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism.
The Biochemical journal 2000;350 Pt 2():599-608.
2000: Asish K Saha; A J Schwarsin; Raphael Roduit; F Masse; Virendar K Kaushik; Keith Tornheim; Marc Prentki; Neil B Ruderman
Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside.
The Journal of biological chemistry 2000;275(32):24279-83.
2000: Jude T Deeney; Marc Prentki; Barbara E Corkey
Metabolic control of beta-cell function.
Seminars in cell & developmental biology 2000;11(4):267-75.
2000: S Farfari; V Schulz; Barbara E Corkey; Marc Prentki
Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.
Diabetes 2000;49(5):718-26.
2000: Jude T Deeney; Jesper Gromada; Marianne Høy; Hervør L Olsen; C J Rhodes; Marc Prentki; Per-Olof Berggren; Barbara E Corkey
Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
The Journal of biological chemistry 2000;275(13):9363-8.
2000: Barbara E Corkey; Jude T Deeney; Gordon C Yaney; Keith Tornheim; Marc Prentki
The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction.
The Journal of nutrition 2000;130(2S Suppl):299S-304S.
2000: S Susini; Goedele Van Haasteren; Senlin Li; Marc Prentki; Werner Schlegel
Essentiality of intron control in the induction of c-fos by glucose and glucoincretin peptides in INS-1 beta-cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(1):128-36.
1999: Enrique Roche; Jean Buteau; I Aniento; Juan Antonio Reig; Bernat Soria; Marc Prentki
Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1.
Diabetes 1999;48(10):2007-14.
1999: L Segall; Nathalie Davis-Lameloise; Françoise Assimacopoulos-Jeannet; E Roche; P Corkey; S Thumelin; Barbara E Corkey; Marc Prentki
Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells.
The American journal of physiology 1999;277(3 Pt 1):E521-8.
1999: Jean Buteau; Raphael Roduit; S Susini; Marc Prentki
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells.
Diabetologia 1999;42(7):856-64.
1999: N Voilley; Raphael Roduit; R Vicaretti; C Bonny; Gerard Waeber; Jason R B Dyck; Gary D Lopaschuk; Marc Prentki
Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase.
The Biochemical journal 1999;340 ( Pt 1)():213-7.
1998: S Susini; E Roche; Marc Prentki; Werner Schlegel
Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(12):1173-82.
1998: E Roche; S Farfari; L A Witters; Françoise Assimacopoulos-Jeannet; S Thumelin; Thierry Brun; Barbara E Corkey; Asish K Saha; Marc Prentki
Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.
Diabetes 1998;47(7):1086-94.
1998: Peter A Antinozzi; L Segall; Marc Prentki; J Denis McGarry; Christopher B Newgard
Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.
The Journal of biological chemistry 1998;273(26):16146-54.
1998: Marc Prentki; L Segall; E Roche; S Thumelin; Thierry Brun; J Denis McGarry; Barbara E Corkey; Françoise Assimacopoulos-Jeannet
[Gluco-lipotoxicity and gene expression in the pancreatic beta cell].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1998;():17-27.
1997: Frans Schuit; Anick De Vos; S Farfari; Karen Moens; Daniel Pipeleers; Thierry Brun; Marc Prentki
Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells.
The Journal of biological chemistry 1997;272(30):18572-9.
1997: Marc Prentki; Keith Tornheim; Barbara E Corkey
Signal transduction mechanisms in nutrient-induced insulin secretion.
Diabetologia 1997;40 Suppl 2():S32-41.
1997: Thierry Brun; Françoise Assimacopoulos-Jeannet; Barbara E Corkey; Marc Prentki
Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.
Diabetes 1997;46(3):393-400.
1997: E Roche; Françoise Assimacopoulos-Jeannet; L A Witters; B Perruchoud; Gordon C Yaney; Barbara E Corkey; M Asfari; Marc Prentki
Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1).
The Journal of biological chemistry 1997;272(5):3091-8.
1997: Françoise Assimacopoulos-Jeannet; S Thumelin; E Roche; Victoria Esser; J Denis McGarry; Marc Prentki
Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.
The Journal of biological chemistry 1997;272(3):1659-64.
1996: Vildan N. Civelek; Jude T Deeney; N J Shalosky; Keith Tornheim; R G Hansford; Marc Prentki; Barbara E Corkey
Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP.
The Biochemical journal 1996;318 ( Pt 2)():615-21.
1996: Marc Prentki
New insights into pancreatic beta-cell metabolic signaling in insulin secretion.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(3):272-86.
1996: Marc Prentki; Barbara E Corkey
Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
Diabetes 1996;45(3):273-83.
1996: Thierry Brun; E Roche; Françoise Assimacopoulos-Jeannet; Barbara E Corkey; K H Kim; Marc Prentki
Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling.
Diabetes 1996;45(2):190-8.
1995: M Frödin; N Sekine; E Roche; Chantal Filloux; Marc Prentki; C B Wollheim; Emmanuel Van Obberghen
Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.
The Journal of biological chemistry 1995;270(14):7882-9.
1994: Senlin Li; C Godson; E Roche; Shujie Zhao; Marc Prentki; Werner Schlegel
Induction of c-fos in pituitary cells by thyrotrophin-releasing hormone and phorbol 12-myristate 13-acetate depends upon Ca2+ influx.
Journal of molecular endocrinology 1994;13(3):303-12.
1994: E Roche; Marc Prentki
Calcium regulation of immediate-early response genes.
Cell calcium 1994;16(4):331-8.
1994: Marc Prentki; Thierry Brun; E Roche
[Nutriments, insulin secretion and gene expression in the pancreatic beta cell].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1994;():1-11.
1993: Thierry Brun; E Roche; K H Kim; Marc Prentki
Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1).
The Journal of biological chemistry 1993;268(25):18905-11.
1993: G Werlen; Dominique Belin; Béatrice Conne; E Roche; Daniel Lew; Marc Prentki
Intracellular Ca2+ and the regulation of early response gene expression in HL-60 myeloid leukemia cells.
The Journal of biological chemistry 1993;268(22):16596-601.
1992: Jude T Deeney; Keith Tornheim; H M Korchak; Marc Prentki; Barbara E Corkey
Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells.
The Journal of biological chemistry 1992;267(28):19840-5.
1992: Marc Prentki; S Vischer; M C Glennon; Romano Regazzi; Jude T Deeney; Barbara E Corkey
Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.
The Journal of biological chemistry 1992;267(9):5802-10.
1991: E A Longo; Keith Tornheim; Jude T Deeney; B A Varnum; D Tillotson; Marc Prentki; Barbara E Corkey
Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets.
The Journal of biological chemistry 1991;266(14):9314-9.
1989: Barbara E Corkey; M C Glennon; K S Chen; Jude T Deeney; Franz M Matschinsky; Marc Prentki
A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells.
The Journal of biological chemistry 1989;264(36):21608-12.
1989: Jean-Francois H Geschwind; Marcia Hiriart; M C Glennon; Habiba Najafi; Barbara E Corkey; Franz M Matschinsky; Marc Prentki
Selective activation of Ca2+ influx by extracellular ATP in a pancreatic beta-cell line (HIT).
Biochimica et biophysica acta 1989;1012(1):107-15.
1988: Marc Prentki; M C Glennon; A P Thomas; R L Morris; Franz M Matschinsky; Barbara E Corkey
Cell-specific patterns of oscillating free Ca2+ in carbamylcholine-stimulated insulinoma cells.
The Journal of biological chemistry 1988;263(23):11044-7.
1988: Barbara E Corkey; Keith Tornheim; Jude T Deeney; M C Glennon; J C Parker; Franz M Matschinsky; Neil B Ruderman; Marc Prentki
Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract.
The Journal of biological chemistry 1988;263(9):4254-8.
1988: Barbara E Corkey; Jude T Deeney; M C Glennon; Franz M Matschinsky; Marc Prentki
Regulation of steady-state free Ca2+ levels by the ATP/ADP ratio and orthophosphate in permeabilized RINm5F insulinoma cells.
The Journal of biological chemistry 1988;263(9):4247-53.
1987: Marc Prentki; Franz M Matschinsky
Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion.
Physiological reviews 1987;67(4):1185-248.
1987: Marc Prentki; M C Glennon; Jean-Francois H Geschwind; Franz M Matschinsky; Barbara E Corkey
Cyclic AMP raises cytosolic Ca2+ and promotes Ca2+ influx in a clonal pancreatic beta-cell line (HIT T-15).
FEBS letters 1987;220(1):103-7.
1986: Marc Prentki; Jude T Deeney; Franz M Matschinsky; S K Joseph
Neomycin: a specific drug to study the inositol-phospholipid signalling system?
FEBS letters 1986;197(1-2):285-8.
1986: Franz M Matschinsky; M Meglasson; A Ghosh; M Appel; F Bedoya; Marc Prentki; B Corkey; T Shimizu; D Berner; Habiba Najafi
Biochemical design features of the pancreatic islet cell glucose-sensory system.
Advances in experimental medicine and biology 1986;211():459-69.
1985: Marc Prentki; Barbara Corkey; F M Matschinsky
Inositol 1,4,5-trisphosphate and the endoplasmic reticulum Ca2+ cycle of a rat insulinoma cell line.
The Journal of biological chemistry 1985;260(16):9185-90.
1982: F Assimacopoulos-Jeannet; J G McCormack; Marc Prentki; B Jeanrenaud; R M Denton
Parallel increases in rates of fatty acid synthesis and in pyruvate dehydrogenase activity in isolated rat hepatocytes incubated with insulin.
Biochimica et biophysica acta 1982;717(1):86-90.